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The creation of babies whose DNA has been altered to give them what parents perceive to be the best chances in life has received a cautious green light in a landmark report from a leading UK ethics body.
The Nuffield Council on Bioethics said that changing the DNA of a human embryo could be morally permissible if it was in the future childs interests and did not add to the kinds of inequalities that already divide society.
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Sports Illustrated model Kate Upton and her husband, Houston Astros pitcher Justin Verlander, announced Saturday they are expecting their first child. Upton announced her pregnancy in an Instagram post with a hashtag and photo of herself showing a tiny baby bump. Its unclear how far along Upton is, but the 26 year-old beauty told E! News that she had been keeping the news on the down low and was excited to finally be able to share it with the world!
Even though studies have confirmed women are more likely to have their first child in their early 30s rather than in their 20s, Upton is onto something. Theres no wrong time to bear children babies truly are a blessing but research and anecdotes show women may want to consider having babies when theyre younger if they can. Here are five reasons why.
Though statistics from the Centers for Disease Control and Prevention show women are waiting longer to have babies many start around age 28 and later scientific findings show a womans biological clock is a real thing, and it ticks well before she hits her 30s.
Dr Charanjit Kaur is a senior consultant, obstetrician and gynecologist, in the Sukhda Hospital in South Delhi. He believes the biological clock is a reality and procrastinating isnt a good idea. The best time to have babies is of course between 20s and 30s. A woman is young and has the vigour to have babies, he told the Hindustan Times. Sadly, the scary trend I have been noticing is that women are opting for their first pregnancy at around 32-33 years.
Scientists at the National Institute of Environmental Health Sciences in North Carolina and the University of Padua in Italy studied 872 healthy couples. The Daily Mail reports: They say 19 to 26-year-olds have a 50 percent chance of conceiving two days before ovulation a womans most fertile time. That drops to 40 per cent for those aged 27 to 34. Their research is the first to indicate that female fertility declines before the age of 30.
According to the ancient Greeks, the apple represented abundance and fertility. In some quarters, it was customary for a bride to eat an apple on her wedding night. This was believed to ensure sexual desire, as well as fertility leading to babies.
You might think that's all a silly superstition. But Italian researchers discovered women who eat an apple a day may in fact enjoy better sexual function.
This month we are showcasing some of the supportive communities in our network, all of which offer so much to families in the UK. Our second blog for this month comes from Lynne Barton of Entrust Care Partnership.
In 2013 our organisation was set up as a response to the aspirations expressed by families caring for children, young people and adults with disabilities, additional or specific needs. People told us that they wanted services which they could trust, which were flexible and demonstrated a warmth for those closest to them, and our three Directors all have a wealth of experience in this field. All the money that we raise provides direct services for the benefit of disabled children, young people, adults, and families.
Our regular activities include a Toddler Group in Harbury, Leamington for parents and carers and children under 5 years old; Play & Stay sessions to bring together parents and carers whose child has recently received a diagnosis or identification of a disability or additional need. We hold these in local Childrens Centres; Disability Awareness training that we hold in partnership with Family Voice Warwickshire provided to professionals across the UK; a Life Skills Group for young adults with disabilities to support them to fulfil their goals and aspirations; Lets Get Healthy sessions covering physical activity and healthy eating during school and college holiday periods.
This image shows a 50 pound (22.7kg) cyst, removed from a womans abdomen. Pretty confronting, isnt it? Whats even more confronting is knowing the womans doctors ignored her pain and discomfort for months. Its a narrative we hear too often: a woman goes to the doctor in pain, her symptoms are brushed off, and shes dismissed as being dramatic, needing to lose weight, or feeling anxiety. Kayla Rahn, 30, from Montgomery, Alabama, had experienced abdominal pain and unexplained weight gain for months. When she eventually sought help from a physician, she was simply told to lose weight.
Most parents spend a lot of time wondering why their kids wont listen. Are they doing it deliberately? Do they need their hearing checked? What's going on with kids these days? As a mama to five, I do my fair share of struggling to get my children to listen. Since having my youngest, Ive also been thrown into the world of physical and occupational therapy. My mind has been absolutely blown by the intricate relationship between childrens opportunity for movement and their behaviour. Our modern parenting styles might be interfering with our children getting the level of movement they need to develop the ability to concentrate and listen to directions.
PMID: Chin Med J (Engl). 2018 Jul 20 ;131(14):1694-1701. PMID: 29998889 Abstract Title: Effect of Dandelion Extracts on the Proliferation of Ovarian Granulosa Cells and Expression of Hormone Receptors. Abstract: Background: In the current society, infertility related to age has become a social problem. The in vitro fertilization (IVF) success rate in women with poor ovarian response (POR) is very low. Dandelion extract T-1 (DE-T1) is an effective component of the extract from the leaves and stems of Taraxacum officinale, which is one of the medicines used in some patients with POR, but its molecular mechanism remains unclear.Methods: Following IVF, ovarian granulosa cells (GCs) of sixty patients were extracted and divided into normal ovarian response (NOR) and POR groups. GCs were cultured in a dose-dependent and time-dependent manner with DE-T1, proliferation of GCs was determined by Cell Counting Kit-8 assay, and mRNA levels of insulin-like growth factor 1 receptor (IGF-1R), luteotropic hormone receptor (LHR), follicle-stimulating hormone receptor (FSHR), LHR, and CYP19A1 (aromatase) were determined by quantitative polymerase chain reaction. Progesterone and estradiol (E2) concentrations were determined by enzyme-linked immunosorbent assay.Results: The cell viability gradually increased with the progressive increase in the DE-T1 concentration. Compared with the control group (without DE-T1), the mRNA expressions of FSHR, LHR, IGF-1R, and CYP19A1 were upregulated after the addition of DE-T1, especially in the 2.5% DE-T1 group (P
UK ethics body says gene-edited babies may be 'morally permissible'Thomson Reuters FoundationLONDON, July 17 (Reuters) - The use of gene editing technologies to alter the DNA of human embryos could be morally permissible as long as the science and its impact on society is carefully considered, a British ethics panel said on Tuesday. Experts ...and more
PMID: Curr Dev Nutr. 2017 Aug ;1(8):e000448. Epub 2017 Jul 18. PMID: 29955715 Abstract Title: Trends in Cruciferous Vegetable Consumption and Associations with Breast Cancer Risk: A Case-Control Study. Abstract: The chemopreventive activities of cruciferous vegetables were recognized in the early 1990s, followed by a growth of evidence in various cancer models, including breast cancer. To our knowledge, no studies have examined whether consumption of cruciferous vegetables has changed accordingly, and what impact, if any, on breast cancer risk may have resulted.The time trend in cruciferous vegetable intake was investigated between 1982 and 1998, and its associations with breast cancer risk were examined.In a hospital-based case-control study in 1491 patients with breast cancer and 1482 controls, loess curves were constructed to describe the relation between median consumption of cruciferous vegetables and year of admission. ORs and 95% CIs were calculated with unconditional logistic regression, adjusting for age, year of admission, family income, body mass index, cigarette smoking, age at menarche, parity, age at first birth, family history of breast cancer, hormone replacement therapy, and total meat intake.Consumption patterns differed between cases and controls. A slow but steady increase in cruciferous vegetable intake was observed in the cases, although among controls, cruciferous vegetable consumption increased from 1982 to 1987, reached a plateau during 1988-1992, and then declined from 1993 to 1998. Accordingly, although an overall inverse association with breast cancer risk was observed for cruciferous vegetable intake (highest compared with lowest quartile-OR: 0.68; 95% CI: 0.55, 0.86;-trend = 0.0006), the inverse association tended to be more pronounced within more recent-year strata, with an OR of 0.52 (95% CI: 0.33, 0.83) for 1993-1998 compared with an OR of 0.89 (95% CI: 0.64, 1.23) for 1982-1987.The consumption of cruciferous vegetables increased during the past 2 decades, showing different trends in cases and controls. The subtle but sustained increase in cruciferous vegetable intake reported by the cases could influence association studies with breast cancer risk.
PMID: Environ Sci Pollut Res Int. 2018 Jul 13. Epub 2018 Jul 13. PMID: 30006815 Abstract Title: Unraveling molecular targets of bisphenol A and S in the thyroid gland. Abstract: Bisphenol A (BPA) is a well-known endocrine disruptor with several effects on reproduction, development, and cancer incidence, and it is highly used in the plastic industry. Bisphenol S (BPS) was proposed as an alternative to BPA since it has a similar structure and can be used to manufacture the same products. Some reports show that BPA interferes with thyroid function, but little is known about the involvement of BPS in thyroid function or how these molecules could possibly modulate at the same time the principal genes involved in thyroid physiology. Thus, the aims of this work were to evaluate in silico the possible interactions of BPA and BPS with the thyroid transcription factors Pax 8 and TTF1 and to study the actions in vivo of these compounds in zebrafish thyroid gene expression. Adult zebrafish treated with BPA or BPS showed that sodium iodide symporter, thyroglobulin, and thyroperoxidase genes were negatively or positively regulated, depending on the dose of the exposure. Human Pax 8 alignment with zebrafish Pax 8 and Rattus norvegicus TTF1 alignment with zebrafish TTF1 displayed highly conserved regions in the DNA binding sites. Molecular docking revealed the in silico interactions between the protein targets Pax 8 and TTF1 with BPA and BPS. Importance of some amino acids residues is highlighted and ratified by literature. There were no differences between the mean energy values for BPA docking in Pax 8 or TTF1. However, BPS energy values were lower in TTF1 docking compared to Pax 8 values. The number of amino acids on the protein interface was important for Pax 8 but not for TTF1. The main BPA interactions with proteins occurred through Van der Waals forces and pi-alkyl and alkyl interactions, while BPS interactions mainly occurred through carbon hydrogen bonds and conventional hydrogen bonds in addition to Van der Waals forces and pi-alkyl interactions. These data point to a possible interaction of BPA and BPS with Pax 8 and TTF1.
He once championed a bill to stop the state from requiring the addition of fluoride to the public drinking water supply unconvinced of the efficacy of the decades-long practice.
He would eliminate the state Commission on Human Rights and Opportunities, open up juvenile court proceedings to the public and establish a state holiday for Ronald Reagans Feb. 6 birthday.
And when all public and private universities in the state were required to adhere to a yes means yes sexual consent law in 2016, he cast the lone vote against the measure in the state Senate and said it was a government overreach into the bedroom.
Now, this dogmatic conservative could be one heartbeat away from being governor, not of Texas or Indiana, but Connecticut: Joe Markley.
The veteran state senator from Southington is a clear favorite to win the Republican nomination for lieutenant governor next month in a three-way primary after nabbing the partys endorsement at its May convention.
Markley was asked Wednesday night why he wants the job during a constituent town hall, where he apologetically arrived 25 minutes late and left a half-hour early in between political stops.
I want to elect a Republican and I want to hold him to our principles, Markley said of a potential partnership with one of the five GOP candidates for governor.
Lawmakers on both sides of the aisle termed Markley, 61, who returned to the Senate in 2011 after a 24-year hiatus, as an affable and bright colleague.
But Democrats and more traditional moderate Republicans say that the right wing agenda of the Amherst College and Columbia University-educated Markley does not comport with the views of most voters in blue Connecticut.
He was the tea party before the tea party was fashionable, said Senate Majority Leader Bob Duff, a Democrat from Norwalk. Heck of a nice guy. We get along fine personally. We just dont agree on much.
Bob MacGuffie, a tea party stalwart from Fairfield, said the Republican base knows that Markley wont sell out.
Hes a constitutional conservative, MacGuffie said. I think hed be a very steady oar in the water for the state. Hes a realist. He calls it as it is all the time.
The lieutenant governor of Connecticut wields tremendous power, especially when it comes to breaking ties in the state Senate, where the No. 2 officeholder serves as president of the chamber.
Once upon a time, it was the deciding vote on the passage of the state income tax, Markley told about 35 constituents Wednesday night at the Southington Municipal Center.
PMID: Andrologia. 2018 May 14:e13036. Epub 2018 May 14. PMID: 29761542 Abstract Title: Ameliorative effect of resveratrol on testicular oxidative stress, spermatological parameters and DNA damage in glyphosate-based herbicide-exposed rats. Abstract: In this study, the reproductive impacts of being exposed to glyphosate (GLF) and the protective impacts of resveratrol (RES) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES, group II received normal feed containing 20 mg kgdailyRES, group III received normal feed containing 375 mg kgdailyGLF, and group IV received normal feed containing 375 mg kgdailyGLF+20 mg kgdailyRES. GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats. On the other hand, abnormal sperm rate, malondialdehyde level, and DNA damage were detected to be high in the group treated with GLF. The findings indicate that RES protects spermatological parameters and DNA damage, decreases GLF-induced lipid peroxidation, improves the antioxidant defence mechanism and regenerates tissue damage in the testis of rats.
The data say yes: yet the FDA might approve the vaccine for adults. Action Alert!
A new study shows that women aged 25-29 who received the HPV vaccine have a lower probability of becoming pregnant. This is just the latest in a stream of evidence that points to the dangers of the HPV vaccine, particularly to those already infected with the virusyet the FDA is considering a request from Merck to expand the population to whom the vaccine can be marketed. If the request is granted, it would be another example of how the agency sells out consumers for the benefit of the vaccine industry.
In addition to the study on the HPV vaccine preventing pregnancies, the governments vaccine adverse event reporting system (VAERS) lists a startling 57,287 adverse events from the vaccine, including 419 deathsfar more than any other vaccine. A World Health Organization study demonstrated that the vaccination has a tendency to produce clusters of serious adverse events. The American College of Pediatricians raised concerns that the vaccine could be li...
PMID: Arch Toxicol. 2018 Jun 9. Epub 2018 Jun 9. PMID: 29947892 Abstract Title: Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats. Abstract: Glyphosate-based herbicides (GBHs) are the most globally used herbicides raising the risk of environmental exposition. Here, we investigated whether perinatal exposure to low doses of a GBH alters the female reproductive performance, and/or induced second-generation effects related to congenital anomalies or growth alterations. Pregnant rats (F0) received a GBH through food, in a dose of 2 mg (GBH-LD: GBH-low dose group) or 200 mg (GBH-HD: GBH-high dose group) of glyphosate/kg bw/day from gestational day (GD) 9 until weaning. Body weight gain and vaginal canal-opening of F1 females were recorded. Sexually mature F1 females were mated to evaluate their reproductive performance by assessing the pregnancy rate, and on GD19, the number of corpora lutea, the implantation sites (IS) and resorption sites. To analyze second-generation effects on F2 offspring, we analyzed the fetal morphology on GD19, and assessed the fetal length and weight, and the placental weight. GBH exposure neither altered the body weight gain of F1 females, nor vaginal opening onset. Although all GBH-exposed F1 rats became pregnant, a lower number of IS was detected. F2 offspring from both GBH groups showed delayed growth, evidenced by lower fetal weight and length, associated with a higher incidence ofsmall for gestational age fetuses. In addition, higher placental weight and placental index were found in F2 offspring from GBH-HD dams. Surprisingly, structural congenital anomalies (conjoined fetuses and abnormally developed limbs) were detected in the F2 offspring from GBH-HD group. In conclusion, perinatal exposure to low doses of a GBH impaired female reproductive performance and induced fetal growth retardation and structural congenital anomalies in F2 offspring.
(HRW) Zaid Itani, the well-known actor exonerated of spying for Israel, has described in detail his forced disappearance in Lebanon and torture in detention, Human Rights Watch said today. On May 29, 2018, military investigative judge, Riad Abu Ghaida, closed the case against Itani and charged two people with falsely accusing him. Itani was released without bail on March 13. Lebanese authorities should conduct a thorough and impartial investigation of Itanis allegations of forced disappearance and torture at the hands of State Security, Human Rights Watch said.
Itani told Human Rights Watch in March that after his arrest in November 2017, he was held in what may have been an informal detention center where men in civilian clothing beat him repeatedly, tied him in a stress position, hung him by his wrists, kicked him in the face, threatened to rape him, and threatened his family with physical violence and legal charges. Details of the investigation were leaked to the media within a day of his arrest, and Itani said interrogators, reportedly from State Security, used the damage to his reputation to put additional pressure on him to confess. Lebanese authorities should investigate how details of the investigation leaked to the media, Human Rights Watch said.
Itanis allegations of torture and disappearance demand a thorough investigation into his treatment in detention and why he was arrested in the first place, said Lama Fakih, deputy Middle East director at Human Rights Watch. If Itani was indeed framed, then this was a massive miscarriage of justice, and authorities should guarantee that this can never happen again.
Itani said that he was held for six days in what appeared to be an unofficial detention site, where men in civilian clothing tortured him until he signed a confession, and only then turned him over to the military court.
Local media reported that the former head of the Internal Security Forces cyber-crimes bureau, Suzan Hobeiche, and a hacker Elie Ghabash, were charged with falsely accusing Itani under article 403 of Lebanons penal code, and face up to 10 years in prison. Ghabash has also been accused of fabricating...
Russia is known for a lot of things; vodka, the Kremlin, Matryoshka dolls and even former KGB member turned Prime Minister, Vladimir Putin. But lately, there has been something much more concerning that has been highly popular with Russias teenagers, the Blue Whale Suicide Game. And its as alarming as it sounds. Find out how one Russian citizen has not only managed to put an entire generation in danger, but even scarier, the game has been spreading around the world like wildfire. Is the game just a myth, or the actual truth?
Read on and decide for yourself.
Parenting these days has had a dramatic change over the last few decades. With the introduction of the Internet, social media and a number of gadgets, kids these days are now privy to an entirely different, and at times, vexing new world.
New parents often wonder whether introducing solids early will help their baby sleep longer. There is a common belief that solid food or formula top up feeds can help to 'fill' babies and this might increase the time a baby sleeps in one go. But is this true? Despite new research suggesting that introducing babies to solids early helps them sleep better, most of the research published on this topic actually suggests the opposite.
Electronic fetal monitoring in labour is a routine practice in most countries such as the US, UK and Australia. Many women would be surprised to know there is no evidence to support the use of this form of monitoring. Even more surprising is the link between the use of electronic fetal monitoring (EFM) and c-section birth.
Wouldnt it be nice to live in a world where this article was unnecessary? A world where people didnt comment on women's bodies pregnant or otherwise. A world where women were able to enjoy their pregnancies, free from the judgemental eyes of society. A world where womens bodies were simply accepted and celebrated instead of compared and criticised. Sadly though, we dont live in that world. Not yet, anyway. We can create that kind of world though, by taking the first step and stopping ourselves from commenting on the size of the bumps of the pregnant women we encounter.
Midwives often talk about how we can re-collect the kinds of knowledge which were held by our predecessors who attended births before they were taken over by medicalisation and moved out of the home environment. Occasionally, somebody discovers knowledge which is both old and new, recognises its implications, and this becomes their passion. Such was the case with Jean Sutton and the rhombus of Michaelis, an area of the lower back which plays a key role in physiological birth. Much of this article is based on a discussion / interview with Jean which took place during August 2002; her words are in italics. Much of it is still just as relevant today.
Before we get into the finer details of what Jean affectionately calls the rhombus, I should add that part of the point in writing about this is that this is the kind of knowledge that some midwives will see as very obvious; they will have read about it before (e.g. Sutton 2000), heard Jean speak, visited her website or be independently aware of this feature of birthing bodies. They might be surprised that anyone feels the need to write about it again. Yet others will not have heard of the rhombus of Michaelis or of the difference that their knowing about this can make to the women they attend. Such has been my experience in talking to midwives about this kind of experiential / physiological knowledge or, as Jean calls it, womens wisdom. What seems obvious to one midwife will be news to another.
In Jeans words, The rhombus of Michaelis (sometimes called the quadrilateral of Michaelis) i...
There are lots of false rumours about toddlers. They are so misunderstood. Toddlers are stereotyped as tiny tyrants who cause trouble for fun. I mean, sure, they do that some of the time, but its certainly not their full-time job. Toddlers are unpredictable, wild, beautiful creatures. They can fill your heart with love and drive you crazy all at the same time. They are still tiny enough to get away with things, but are developed enough to know their own mind and this is a good thing, until you try to leave the house in a hurry.
Youre newly pregnant and desperate to share the news. You find yourself longing to talk about the pregnancy. Twelve weeks can feel like a long time to keep your secret especially when youre bursting with excitement and desperate to shout it from the rooftops. In hindsight, once baby has arrived, you might realise those early weeks were a break from the monotony of being asked questions.
Safety and sleep. They are the two major priorities for new parents. All parents want to do everything they can to keep their little ones safe. But new parents are also desperate to get adequate rest. As parents, we can't avoiding thinking about the risks of Sudden Infant Death Syndrome (SIDS), accidental suffocation, and strangulation. From the moment you announce you're pregnant, you're told over and over again: babies need to be placed on their backs to sleep. Yes. We should place babies on their backs to sleep. And we shouldnt use pillows, thick blankets, or bumpers.
British medical experts are recommending children be taught about breastfeeding in schools. This is being done in a bid to encourage more women to breastfeed from birth and beyond. Data published in general medical journal The Lancet shows the UK has one of the worst breastfeeding rates in the world. Less than 35% of UK babies are still breastfed at six months, compared with almost 50% in the US and 71% in Norway.
It is one of the most amazing feats the human body has proven capable of achieving, the creation of another living being. While we watch and marvel from the outside, taking photographs of the growth of our baby bumps and debating topics like doulas and birth plans, a true miracle is occurring right below our noses.
It is this very miracle that Swedish photographer Lennart Nilsson (1922 2017) aimed to capture when he took his first black and white photos in 1957, using his talent for photography to document the process of creation from conception to birth. As technology advanced, so too did the ability to take better quality, more realistic photographs. This led Nilsson to repeat the process again in 1965, this time taking unbelievably clear, detailed color photos that have captivated people the world over.
In fact, these very photographs captured the attention of LIFE magazine, with his photograph of an 18-week-old human fetus appearing on the cover of the April 30, 1965 issue. In the associated article, TIME wrote: Ten years ago, a Swedish photographer named Lennart Nilsson told us that he was going to photograph in color the stages of human reproduction from fertilization to just before birth. It was impossible for us not to express a degree of skepticism about his chances of success, but this was lost on Nilsson. He simply said, When Ive finished the story, Ill bring it to you. Lennart kept his promise. He flew into New York from Stockholm and brought us the strangely beautiful and scientifically unique color essay in this issue.
Nilsson used wide-angled optics and specialized macro-lenses, capturing embryos and fetuses in ground-breaking in utero photography that would be immortalized for years to come. They were images that the world had never before seen.
The first job I did for [LIFE] on an exclusive basis was when Dag Hammarskjold was elected UN Secretary General in 1952. I traveled to New York with him and photographed the newly installed Secretary General in his office in the 38th floor in the UN Building, Nilsson told interviewers. I had my first embryo pictures along with me on that trip. Unbelievable! they said at LIFE. I thought so, too! But I didnt know anything about the development o the fetus and had to learn from scratch. But they were incredibly enthusiastic at LIFE and twelve years later, in 1965, they published their big story on human reproduction.
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