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Dane Wigington GeoengineeringWatch.org How much of what we believe is actually nothing more than societal programming from the constant parade of propaganda? How many crimes and injustices does society accept because of being trained to never question the experts? Belief systems will not alter reality or the immense challenges that are closing in from every direction. The latest
If I didnt have the authentic YouTube video of vaccine-pushing-authority, Dr. Paul Offit, MD, to share with my readers below, you probably would think Ive gone off my rocker, especially if I only quoted him and did not have the physical, visual and audio proof of his admitting numerous suppressed deprecating facts about vaccinations, thereby further empowering parents valid reasons for NOT vaccinating their beloved children.
Here are some acknowledgements Dr. Offit finally admits to about vaccinations:
Paul Offit Says Vaccination is a Violent
Parents probably remember it was Dr. O...
Note from Fluoride Action Network: This regulation is currently in effect
Louisiana SIP [State Implementation Plan]: LAC 33:III Ch 23 Subchap C, 2305Phosphate Fertilizer Plants, 2305 Fluoride Emission Standards for Phosphate Fertilizer Plants; SIP effective 1989-05-08 (LAc49)
Louisiana Administrative Code, Title 33 ENVIRONMENTAL QUALITY, Part III Air (LAC 33:III)
Chapter 23. Control of Emissions for Specific Industries
Subchapter C. Phosphate Fertilizer Plants
Section 2305. Fluoride Emission Standards for Phosphate
Fertilizer Plants. LAc49
Approved by EPA 03/08/89 (54 FR 09795) at 52.970(c)(49) effective 05/08/89.
A. Purpose. The purpose of this Subchapter shall be to limit the quantity of atmospheric fluoride emissions from phosphate fertilizer plants.
B. Scope. This Subchapter applies to those phosphate fertilizer plants which were constructed, or under construction or modification, prior to August 6, 1975.
C. Definitions. Terms defined in Chapter 31 herein, shall have the same meaning when used herein.
D. Emission Limitations. On and after the date which each affected facility is required to be compliance, no owner or operator subject to this regulation shall cause to be discharged into the atmosphere from any affected facility any gases which contain total fluorides in excess of the quantities listed below for each facility.
1. Wet-Process Phosphoric Acid Plants 0.10 pounds of total fluorides per ton (50.0 grams/metric ton) of equivalent P2O5 feed.
2. Superphosphoric Acid Plants. 1.10 pounds of total fluorides per ton (550 grams/metric ton) of equivalent P2O5 feed.
3. Diammonium Phosphate Plants. 0.18 pounds of total fluorides per ton (90.0 grams/metric ton) of equivalent P2O5 feed.
E. Test Methods and Procedures. Test methods and procedures for determining compliance with this regulation shall be identical to those specified in 40 CFR 60 for corresponding types of plants or equivalent test methods and procedures approved by the administrative authority.
AUTHORITY NOTE: Promulgated in accordance with R.S.
HISTORICAL NOTE: Promulgated by the Department of Environmental Quality, Office of air Quality and Nuclear Energy, Air Quality Division in LR 13:741 (December 1987).
*Online as of October 13, 2018, at...
Research indicates that you don't need drugs to control blood sugar. Food, herbs, and spices are the future of medicine.
Before we present this weeks Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured more than a dozen corrections at Sloan Kettering, three retractions Continue reading Weekend reads: Fired for challenging authorship?; homeopathy paper earns a flag; sentenced to playing piano for embezzling research funds
The past of our ancestors lives on through us: Groundbreaking research illustrates how parental experience is not only epigenetically imprinted onto offspring, but onto an unprecedented number of future generations. Rather than occurring over the elongated time scale of millions of years, genetic change can transpire in real biological time through nanoparticles known as exosomes.
PMID: Drug Chem Toxicol. 2018 Sep 7:1-7. Epub 2018 Sep 7. PMID: 30192646 Abstract Title: Niacin prevents mitochondrial oxidative stress caused by sub-chronic exposure to methylmercury. Abstract: Humans and animals can be exposed to different chemical forms of mercury (Hg) in the environment. For example, methylmercury (MeHg)-contaminated fish is part of the basic diet of the riparian population in the Brazilian Amazon Basin, which leads to high total blood and plasma Hg levels in people living therein. Hg induces toxic effects mainly through oxidative stress. Different compounds have been used to prevent the damage caused by MeHg-induced reactive oxygen species (ROS). This study aims to investigate the in vivo effects of sub-chronic exposure to low MeHg levels on the mitochondrial oxidative status and to evaluate the niacin protective effect against MeHg-induced oxidative stress. For this purpose, Male Wistar rats were divided into four groups: control group, treated with drinking water on a daily basis; group exposed to MeHg at a dose of 100g/kg/day; group that received niacin at a dose of 50mg/kg/day in drinking water, with drinking water being administered by gavage; group that received niacin at a dose of 50mg/kg/day in drinking water as well as MeHg at a dose of 100g/kg/day. After 12weeks, the rats, which weighed500-550g, were sacrificed, and their liver mitochondria were isolated by standard differential centrifugation. Sub-chronic exposure to MeHg (100g/kg/day for 12weeks) led to mitochondrial swelling (p
PMID: J Med Food. 2017 Dec ;20(12):1240-1249. Epub 2017 Sep 28. PMID: 28956702 Abstract Title: The Effect of Anthocyanin-Rich Purple Vegetable Diets on Metabolic Syndrome in Obese Zucker Rats. Abstract: Consumption of highly colored fruits and vegetables rich in anthocyanins has been associated with numerous health benefits. Purple carrots (PC) and purple potatoes (PP) have higher anthocyanin concentrations and higher biological activities compared with less pigmented cultivars. We hypothesized that substitution of the majority of carbohydrate in a high fat diet with PP or PC, for 8 weeks, would improve insulin resistance and hypertension, major components of metabolic syndrome, compared with orange carrots (OC), white potatoes (WP) or a control, high fat, sucrose-rich diet (HFD) in obese Zucker rats. After 8 weeks of feeding, intraperitoneal glucose tolerance test, intraperitoneal insulin tolerance test (ipITT), and invasive hemodynamic tests were performed. The PP group had better glucose tolerance compared with the WP and the HFD groups and higher insulin sensitivity as measured by the ipITT and homeostatic model assessment of insulin resistance (P=.018) compared with the HFD without having any effect on blood pressure. The PC reduced left ventricular pressure compared with both the HFD (P=.01) and the OC (P=.049) groups and reduced systolic and diastolic blood pressures compared with the HFD group (P=.01 and
PMID: BMC Complement Altern Med. 2018 Jul 13 ;18(1):216. Epub 2018 Jul 13. PMID: 30005651 Abstract Title: Ipomoea batatas L. Lam. ameliorates acute and chronic inflammations by suppressing inflammatory mediators, a comprehensive exploration using in vitro and in vivo models. Abstract: BACKGROUND: Ipomoea batatas L. Lam. is a functional food and belongs to family Convolvulaceae. It is used as an antiinflammatory, aphrodisiac, antiasthmatic, anticonvalescent, antitumor, antanemic and antidiabetic agent by local communities. This study has been planned to evaluate its antiinflammatory and antiarthritic potentials.METHODS: Dry powder of I. batatas tuber and roots were extracted with ethyl acetate (IPT-EA, IPR-EA) and methanol (IPT-M, IPR-M), respectively. These extracts were tested for total phenolic and flavonoid contents (TPC and TFC), HPLC finger printing, multidimensional in vitro and in vivo antioxidant potential and albumin denaturation inhibition. Carrageenan-induced paw edema, croton oil-induced ear and anal edema inhibition and Complete Freund's Adjuvant (CFA)-induced antiarthritic assays were executed at a dose of 300 mg/kg body weight on Sprague-Dawley rats. Serum levels of interleukins IL-1 and IL-6 and nitric oxide (NO) were assessed to measure the inhibition of inflammation.RESULTS: Maximal TPC (319.8114.20 g GAE/mg dry extract) and TFC (208.779.09 g QE/mg DE) were estimated in IPR-EA extract. IPT-EA and IPR-EA yielded the maximum amounts of rutin (7.31.12 and 4.50.55), caffeic acid (1.600.25 and 2.170.26) and myricetin (2.70.14 and 1.010.08 g/mg DE), respectively in HPLC-DAD analysis. All extracts showed dose dependent response in in vitro antioxidant assays. Best inhibition (76.923.07%) of albumin denaturation was shown by IPT-EA in comparison to ibuprofen (79.484.71%). IPR-EA exhibited highest edemainhibition in models of carrageenan-induced paw edema (79.115.47%) and croton oil-induced ear and anal edema (72.017.80% and 70.804.94%, respectively). Significant inhibition of CFA-induced arthritic edema and arthritic score were observed by IPR-EA as compared to ibuprofen.Suppression of pro-inflammatory cytokines (IL-1, IL-6) and NO levels was shown by IPR-EA and IPT-EA, respectively.CONCLUSION: These results depict that richness of polyphenols and phytoconstituents in I. batatas ameliorates oxidative stress and inflammation of acute and chronic nature. Dose dependent antioxidant potential and inhibition of inflammatory edema, pro-inflammatory cytokines and hematological, biochemical and histological changes prove I. batatas therapeutic potential as an antiinflammatory and antiarthritic agent.
PMID: Pak J Pharm Sci. 2018 Jul ;31(4(Supplementary)):1539-1548. PMID: 30058546 Abstract Title: Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats. Abstract: Diabetes is a condition where the fasting blood glucose level elevated above the normal range (80-120mg/dL). This increase in blood glucose level may be due to the insulin deficiency i.e. insulin dependent diabetes mellitus (IDDM or type I) or due to insulin resistance i.e. non-insulin dependent diabetes mellitus (NIDDM or type II). Diabetes leads to severe complications in the body even life treating complications e.g. nephropathy, retinopathy, neuropathy increased vascular permeability and delayed wound healing if left untreated. Different drugs are used for the treatment of diabetes mellitus, but synthetic drugs are costly and possess severe side effects. So, more emphasis is being placed on the use of traditional medicines because these sources have fewer side effects than the synthetics drugs and are economical. So the white skinned sweet potato (Ipomoea batatas L.) peel-off was selected for its anti-diabetic effect as well as to see its effects on biochemical parameters. Both young (3-4 months) and old (up to 1 year) Wistar rats were selected for current study. It was found that the aqueous extract of WSSP peel-off had shown beneficial effects. In addition to the decrease in blood glucose level it also decreased protein glycation level total cholesterol, triglycerides, and LDL-cholesterol. Increase in HDL-cholesterol was also observed after treating the rats with aqueous extract of Ipomoea batatas. Additionally, WSSP peel-off had also shown positive results on total protein concentration, albumin, globulin, and plasma enzymes (SGOT and SGPT). Further research would be needed in order to purify the anti-diabetic components and it should be available in compact dose form for all diabetic patients.
PMID: J Med Food. 2018 Jul ;21(7):689-700. Epub 2018 Jun 4. PMID: 29862890 Abstract Title: The Effects of Curcuma longa L., Purple Sweet Potato, and Mixtures of the Two on Immunomodulation in C57BL/6J Mice Infected with LP-BM5 Murine Leukemia Retrovirus. Abstract: The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leukemia virus (MuLV). Mice were divided into seven groups as follows: normal control, infected control (LP-BM5 MuLV infection), positive control (LP-BM5 MuLV infection+dietary supplement of red ginseng 300mg/kg body weight), the original powder of C. longa L. (C; LP-BM5 MuLV infection+dietary supplement of C 189mg/kg body weight), the original powder of purple sweet potato (P; LP-BM5 MuLV infection+dietary supplement of P 1811mg/kg body weight), CPM Low (CPL; LP-BM5 MuLV infection+CPM 2g/kg body weight), and CPM High (CPH; LP-BM5 MuLV infection+CPM 5g/kg body weight). Dietary supplementation lasted for 12 weeks. Dietary supplementation of CPM inhibited LP-BM5 MuLV-induced lymphadenopathy and splenomegaly and inhibited reduction of messenger RNA (mRNA) expression of major histocompatibility complex (MHC) I and II. Moreover, CPM reduced the decrease in T- and B cell proliferation, reduced the population of CD4(+)/CD8(+) T cells, and remedied the unbalanced production of T helper-1 (Th1)/T helper-2 (Th2) cytokines in LP-BM5 MuLV-infected mice. In addition, CPM inhibited reduction of phagocytosis in peritoneal macrophages and decreased serum levels of immunoglobulin A (IgA), immunoglobulin E (IgE), and immunoglobulin G (IgG). These results suggest that CPM had a positive effect on immunomodulation in C57BL/6 mice induced by LP-BM5 leukemia retrovirus infection.
PMID: Wei Sheng Yan Jiu. 2018 Jul ;47(4):517-524. PMID: 30081974 Abstract Title: [Purple sweet potato anthocyanins attenuates steatohepatitis induced by high fat diet combined with carbon tetrachloride in rats]. Abstract: OBJECTIVE: To explore the mechanism of purple sweet potato anthocyanins through NF-B pathway in attenuating steatohepatitis induced by high fat diet combined with carbon tetrachloride in rats.METHODS: Seventy male rats were randomly divided into control group( n = 10) and high-fat diet group( n = 60), models were prepared by highfat diet and intraperitoneal injection of carbon tetrachloride and olive oil( 50 : 50) 2 mL/kg, two times a week. After 10 weeks of feeding, the weight variations of all rats were tested before and after modeling. The colorimetric technique was used to test the concentration of serum ALT, AST, TG, and TC. A total of 58 rats were succeeded in modeling, the random choice of 50 rats were divided into model group, purple sweet potato anthocyanin low dose group( 60 mg/kg), middle dose group( 120 mg/kg), high dose group( 240 mg/kg), positive drug group( 150 mg/kg), 10 rats in each group. After 8 weeks of continuous administration, the method of colorimetric technique was used to test the concentration of ALT, AST, TG, TC, HDL and LDL. The method of ELISA kit was used to test the levels of the pro-inflammatory factors TNF-, IL-1 and the levels of the anti-inflammatory IL-4, IL-13. The Real-time PCR was used to test the expression of TNF-, IL-1, IL-4, IL-13, PPAR- and HMGB-1 mRNA of rats liver. The western blotting method was adopted to test the level of IB phosphorylation in liver tissues as well as the PPAR- and HMGB-1 protein expression.RESULTS: After modeling, the body weight of rats increased( P
From YES! Magazine: As I was reading the current series of YES! articles on the mental health crisis, I received an email from Darcia Narvaez, professor of psychology at University of Notre Dame. She was sending me articles being prepared for an anthology she is co-editing with the working title Sustainable Vision. The articles present lessons from indigenous culture that underscore why community is the solution to so much of what currently ails humanity.
Both these collections underscore why so much of what currently ails us can be traced to the ongoing global process of commodification, monetization, corporatization, and the increasing trend of machines, robots, and artificial intelligence replacing people in jobs ranging from manufacturing to customer service. All this is separating us from one another and from nature so that billionaires can grow their fortunes. The consequencesincluding environmental, social, and political collapseare dramatic, devastating, and unnecessary.
PMID: Molecules. 2018 Aug 17 ;23(8). Epub 2018 Aug 17. PMID: 30126082 Abstract Title: Aqueous-Methanol Extracts of Orange-Fleshed Sweet Potato () Ameliorate Oxidative Stress and Modulate Type 2 Diabetes Associated Genes in Insulin Resistant C2C12 Cells. Abstract: Edible plants such as sweet potato are sources of natural antioxidants that can be exploited in the management and treatment of insulin resistance. This present study investigated the effects of the extracts of an orange-fleshed sweet potato on oxidative stress biomarkers (glutathione status and lipid peroxidation) and activities of antioxidant enzymes (catalase, CAT and glutathione peroxidase, GPx) in palmitate-induced insulin resistant C2C12 cells. The intracellular antioxidant status of the cells was also measured using Ferric reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC) assays. Furthermore, this study determined the effect of the extracts on the regulation of some type 2 diabetes associated genes; glucose transporter 4 (), Nuclear respiratory factor 1 (), Myocyte enhanced factor 2A (), Carnitine palmitoyltransferase 1 () and Acetyl-CoA carboxylase 2 (). The results showed a significant (
PMID: Iran J Basic Med Sci. 2018 May ;21(5):508-516. PMID: 29922432 Abstract Title: Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cell line via activation of apoptosis and MAPK pathways. Abstract: Objectives: Combination chemotherapy is a rational strategy to increase patient response and tolerability and to decrease adverse effects and drug resistance. Recently, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been reported to be associated with reduction in occurrence of a variety of cancers including lung cancer. On the other hand, growing evidences suggest that deuterium-enriched water (DEW, D2O) and deuterium-depleted water (DDW) play a role both in treatment and prevention of cancers. In the present study, we examined the effects of DEW and DDW in combination with two NSAIDs, celecoxib and indomethacin, on A549 human non-small lung cancer cell to identify novel treatment options.Materials and Methods: The cytotoxicity of celecoxib or indomethacin, alone and in combination with DDW and DEW was determined. The COX-2, MAPK pathway proteins, the anti-apoptotic Bcl2 and pro-apoptotic Bax proteins and caspase-3 activity were studied for cytotoxic combinations.Results: Co-administration of selective and non-selective COX-2 inhibitors with DEW led to a remarkable increase in cytotoxicity and apoptosis of A549 cells. These events were associated with activation of p38 and JNK MAPKs and decreasing pro-survival proteins Bcl-2, COX-2 and ERK1/2. Furthermore, the combination therapy activated caspase-3, and the apoptosis mediator, and disabled poly ADP-ribose polymerase (PARP), the key DNA repair enzyme, by cleaving it.Conclusion: The combination of DEW with NSAIDs might be effective against lung cancer cells by influence on principal cell signalling pathways, and this has a potential to become a candidate for chemotherapy.
PMID: Exp Ther Med. 2018 Aug ;16(2):1241-1249. Epub 2018 Jun 19. PMID: 30116375 Abstract Title: Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death. Abstract: Cancer, and particularly colon cancer, is associated with an increasing number of cases resistant to chemotherapy. One approach to overcome this, and to improve the prognosis and outcome of patients, is the use of adjuvant therapy alongside the standard chemotherapy regiment. In the present study, the effect of deuterium-depleted water (DDW) as a potential modulator of adjuvant therapy on DLD-1 colorectal cancer models was assessed. A number of functionality assays were performed, including MTT, apoptosis and autophagy, and mitochondrial activity and senescence assays, in addition to assessing the capacity to modify the pattern of released miRNA via microarray technology. No significant effect on cell viability was identified, but an increase in mitochondrial activity and a weak pro-apoptotic effect were observed in the treated DLD-1 cells cultured in DDW-prepared medium compared with those grown in standard conditions (SC). Furthermore, the findings revealed the capacity of DDW medium to promote senescence to a higher degree compared with SC. The exosome-released miRNA pattern was significantly modified for the cells maintained in DDW compared with those maintained in SC. These findings suggest that DDW may serve as an adjuvant treatment; however, a better understanding of the underlying molecular mechanism of action will be useful for developing novel and efficient therapeutic strategies, in which the transcriptomic pattern serves an important role.
PMID: Basic Clin Pharmacol Toxicol. 2017 Jun ;120(6):560-570. Epub 2017 Mar 7. PMID: 28032440 Abstract Title: Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. Abstract: Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA, 8 mg/kg/week) up to 6 weeks to establish hepatic fibrosis, and magnolol (10, 20, 30 mg/kg/day) was given to these mice orally throughout the whole experiment. We found that magnolol preserved liver function and attenuated liver fibrotic injury in vivo. In response to ConA stimulation, the CD4T cells preferred to polarizing towards CD4T helper 17 (Th17) cells in liver. Magnolol was observed to inhibit Th17 cell differentiation in ConA-treated liver in addition to suppressing interleukin (IL)-17A generation. Hepatic stellate cells were activated in fibrotic liver as demonstrated by increased alpha smooth muscle actin (-SMA) and desmin. More transforming growth factor (TGF)-1 and activin A were secreted into the serum. Magnolol suppressed this abnormal HSC activation. Furthermore, the phosphorylation of Smad3 in its linker area (Thr179, Ser 204/208/213) was inhibited by magnolol. In vitro, the recombinant IL-17A plus TGF-1 or activin A induced activation of human LX2 HSCs and promoted their collagen production. Smad3/Smad4 signalling pathway was activated in LX2 cells exposed to the fibrotic stimuli, as illustrated by the up-regulated phospho-Smad3 and the enhanced interaction between Smad3 and Smad4.These alterations were suppressed by magnolol. Collectively, our study reveals a novel antifibrotic effect of magnolol on Th17 cell-mediated fibrosis.
PMID: Drug Des Devel Ther. 2017 ;11:2653-2661. Epub 2017 Sep 6. PMID: 28919715 Abstract Title: In vitro inhibitory activities of magnolol againstspp. Abstract: spp. cause various infections involving the skin, mucosa, deep tissues, and even life-threatening candidemia. They are regarded as an important pathogen of nosocomial bloodstream infection, with a high mortality rate. As a result of prolonged exposure to azoles, the therapeutic failure associated with azoles resistance has become a serious challenge in clinical situations. Therefore, novel, alternative antifungals are required urgently. In the present study, the CLSI M-27A broth microdilution method and the 2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction assay were used to evaluate the antifungal effects of magnolol against various standardstrains in planktonic mode and biofilm formation, respectively. The antifungal activity of magnolol was demonstrated in planktonicand non-albicansspecies, especially fluconazole-resistant, with the minimum inhibitory concentrations ranging from 10 to 40g/mL. The BMIC(minimum concentration with 90%biofilm inhibited) values of magnolol ranged from 20 to 160g/mL, whereas the BMICvalues of fluconazole were more than 128g/mL. As an alternative and broad-spectrum antifungal agent, magnolol might be of benefit to the treatment of refractoryinfection.
PMID: Am J Chin Med. 2017 ;45(7):1421-1439. Epub 2017 Sep 25. PMID: 28946769 Abstract Title: Magnolol Reduces Renal Ischemia and Reperfusion Injury via Inhibition of Apoptosis. Abstract: Magnolol, a constituent of the bark of Magnolia officinalis, has been reported to decrease myocardial stunning and infarct size. In this study, we investigated whether magnolol can reduce renal ischemia and reperfusion (I/R) injury. Renal I/R, induced by a 60-min occlusion of bilateral renal arteries and a 24-h reperfusion, significantly increased blood urea nitrogen (BUN) and creatinine levels, and caused histological damage to the kidneys of rats. Apoptosis, as evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and caspase-3 activation, was significantly increased in the kidneys. Furthermore, serum levels of tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1 (IL-1), and interleukin-6 (IL-6) were significantly elevated, while the interleukin-10 (IL-10) level was suppressed. However, intravenous pretreatment with magnolol at doses of 0.003[Formula: see text]mg/kg and 0.006[Formula: see text]mg/kg 10[Formula: see text]min before renal I/R significantly limited the increases of BUN, creatinine, the histological damage, and apoptosis in the kidneys. The increases in TNF-[Formula: see text], IL-1, and IL-6, and the decrease in IL-10 were also significantly inhibited. Additionally, magnolol increased Bcl-2 and decreased Bax in the kidneys. Phosphorylation of the prosurvival kinases, including Akt and extracellular signal-regulated kinases 1 and 2 (ERK1/2), was elevated, while phosphorylation of the pro-apoptotic mitogen-activated protein kinases, including p38 and c-Jun N-terminal kinase (JNK), was suppressed. In conclusion, magnolol reducesrenal I/R injury. The underlying mechanisms for this effect might be related to the prevention of apoptosis, possibly via the inhibition of both extrinsic and intrinsic apoptotic pathways, including the reduction of TNF-[Formula: see text] production and the modulation of pro- and anti-apoptotic signaling elements.
PMID: Mol Med Rep. 2018 Mar ;17(3):3455-3464. Epub 2017 Dec 20. PMID: 29286109 Abstract Title: The protective effects of magnolol on acute trinitrobenzene sulfonic acidinduced colitis in rats. Abstract: The present study aimed to investigate the protective effects of magnolol on acute 2,4,6-trinitrobenzene sulfonic acid (TNBS)induced colitis, and its underlying mechanisms. Experimental colitis was induced by intracolonic administration of TNBS/ethanol into rats. The model rats were randomly assigned into groups: TNBS, magnolol (high, medium and low doses), and salazosulfapyridine (positive control). All intervention regimens were administered by oral gavage, once a day for 7 consecutive days, 24 h after colitis induction. Histological and biochemical changes in colonic inflammation were evaluated by hematoxylin and eosin and immunohistochemistry, respectively. Rats treated with all doses of magnolol exhibiteddecreased colonic myeloperoxidase activity (P
A San Francisco judge said Wednesday she is considering tossing out the lions share of the $289 million judgment against agribusiness giant Monsanto and ordering a new trial over whether the companys weed-killer caused a groundskeepers cancer. San Francisco Superior Court Judge Suzanne Bolanos didnt formally rule on any issues after a two-hour hearing to consider Monsantos 
PMID: Int J Mol Med. 2018 Apr ;41(4):2252-2262. Epub 2018 Jan 15. PMID: 29336466 Abstract Title: Magnolol protects against ischemic-reperfusion brain damage following oxygen-glucose deprivation and transient focal cerebral ischemia. Abstract: In the present study, the neuroprotective potential of magnolol against ischemia-reperfusion brain injury was examined via in vivo and in vitro experiments. Magnolol exhibited strong radical scavenging and antioxidant activity, and significantly inhibited the production of interleukin6, tumor necrosis factora and nitrite/nitrate (NOX) in lipopolysaccharide-stimulated BV2 and RAW 264.7 cells when applied at concentrations of 10 and 50 M, respectively. Magnolol (100 M) also significantly attenuated oxygenglucose deprivationinduced damage in neonatal rat hippocampal slice cultures, when administered up to 4 h following the insult. In a rat model of stable ischemia, compared with a vehicletreated ischemic control, pretreatment with magnolol (0.011 mg/kg, intravenously) significantly reduced brain infarction following ischemic stroke, and posttreatment with magnolol (1 mg/kg) remained effective and significantly reduced infarction when administered 2 h following the onset of ischemia. Additionally, magnolol (0.3 and 1 mg/kg) significantly reduced the accumulation of superoxide anions at the border zones of infarction and reduced oxidative damage in the ischemic brain. This was assessed by measuring the levels of NOX, malondialdehyde and myeloperoxidase, the ratio of glutathione/oxidized glutathione and the immunoreactions of 8hydroxy2'deoxyguanosine and 4hydroxynonenal. Thus, magnolol was revealed to protect against ischemiareperfusion brain damage. This may be partly attributed to its antioxidant, radical scavenging and antiinflammatory effects.
PMID: Life Sci. 2018 Mar 1 ;196:69-76. Epub 2018 Feb 2. PMID: 29355546 Abstract Title: Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage. Abstract: Magnolol, the main and active ingredient of the Magnolia officinalis, has been widely used in traditional prescription to the human disorders. Magnolol has been proved to have several pharmacological properties including anti-bacterial, anti-oxidant and anti-inflammatory activities. However, the effects of magnolol on ulcerative colitis (UC) have not been reported. The aim of this study was to investigate the protective effects and mechanisms of magnolol on dextran sulphate sodium (DSS)-induced colitis in mice. The results showed that magnolol significantly alleviated DSS-induced body weight loss, disease activities index (DAI), colon length shortening and colonic pathological damage. In addition, magnolol restrained the expression of TNF-, IL-1 and IL-12 via the regulation of nuclear factor-B (NF-B) and Peroxisome proliferator-activated receptor- (PPAR-) pathways. Magnolol also enhanced the expression of ZO-1 and occludin in DSS-induced mice colonic tissues. These results showed that magnolol played protective effects onDSS-induced colitis and may be an alternative therapeutic reagent for colitis treatment.
PMID: Front Immunol. 2018 ;9:147. Epub 2018 Feb 5. PMID: 29467759 Abstract Title: Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor Activation. Abstract: Magnolol (MG) is a kind of lignin isolated from, which serves several different biological functions, such as antifungal, anticancer, antioxidant, and hepatoprotective functions. This study aimed to evaluate the protective effect of MG against oleic acid (OA)-induced hepatic steatosis and inflammatory damage in HepG2 cells and in a tyloxapol (Ty)-induced hyperlipidemia mouse model. Our findings indicated that MG can effectively inhibit OA-stimulated tumor necrosis factor (TNF-) secretion, reactive oxygen species generation, and triglyceride (TG) accumulation. Further study manifested that MG significantly suppressed OA-activated mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-B) signaling pathways and that these inflammatory responses can be negated by pretreatment with inhibitors of extracellular regulated protein kinase and c-Jun N-terminal kinase (U0126 and SP600125, respectively). In addition, MG dramatically upregulated peroxisome proliferator-activated receptor (PPAR) translocation and reduced sterol regulatory element-binding protein 1c (SREBP-1c) protein synthesis and excretion, both of which are dependent upon the phosphorylation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), acetyl-CoA carboxylase, and AKT kinase (AKT). However, MG suspended the activation of PPAR expression and was thus blocked by pretreatment with LY294002 and compound c (specific inhibitors of AKT and AMPK). Furthermore, MG clearly alleviated serum TG and total cholesterol release; upregulated AKT, AMPK, and PPAR expression; suppressed SREBP-1c generation; and alleviated hepatic steatosis and dyslipidemia in Ty-induced hyperlipidemia mice. Taken together, these results suggest that MG exerts protective effects against steatosis, hyperlipidemia, and the underlying mechanism, which may be closely associated with AKT/AMPK/PPAR activation and MAPK/NF-B/SREBP-1c inhibition.
PMID: Steroids. 2018 Jul ;135:73-78. Epub 2018 Mar 17. PMID: 29555480 Abstract Title: Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection. Abstract: Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depression induced by chronic unpredictable mild stress in previous studies. However, its antidepressant-like effects and mechanisms have never been studied in depression model induced by CORT administration in rodents. This study aimed to investigate the antidepressant-like effects and possible mechanisms of magnolol in CORT-treated mice by utilizing a combination of behavioral and biochemical analysis. The depressive model was developed by subcutaneous injection of CORT for 21days at a dose of 20mg/kg. CORT administration formed depressive-like behaviors in mice, as indicated by increased immobility time in the forced swim test (FST) and tail suspension test (TST), as well as decreased sucrose intake in sucrose preference test (SPT). Moreover, we also found that CORT levels in serum were significantly increased, along with the decrease of brain-derived neurotrophic factor (BDNF) mRNA, BDNF protein, 5-hydroxytryptamine (5-HT) and norepinephrine (NE) levels in the hippocampus. Treatment with magnolol alleviated depressive-like behaviors, reduced the levels of CORT, and improved the levels of BDNF protein, 5-HT, and NE compared with those in CORT-treated mice. These findings indicated that magnolol possessed antidepressant effects in mice exposed to CORT, which might be partially related to modulate HPA axis, up-regulate BDNF expression and increase neurotransmitters levels in the hippocampus.
PMID: Pol J Vet Sci. 2018 Mar ;21(1):111-118. PMID: 29624001 Abstract Title: Magnolol inhibits Streptococcus suis-induced inflammation and ROS formation via TLR2/MAPK/NF-B signaling in RAW264.7 cells. Abstract: Our previous studies have shown that Magnolol (Mag) improves the symptoms and decreases the levels of cytokines during infection induced by Streptococcus suis (S. suis) in mice. Although some reports show that Mag inhibits lipopolysaccharide-induced inflammatory responses via downregulating mitogen-activated protein kinases (MAPK) and nuclear factor-B (NF-B) signaling pathways, the molecular mechanisms underlying Mag-mediated inhibition of S. suis-induced inflammatory responses are poorly understood. Here, RAW264.7 cells were stimulated with S. suis in the presence or absence of Mag. Cell viability and bactericidal effects were examined, and the concentrations of tumor necrosis factor-a (TNF-), IL-1 (interleukin-1), IL-6 (interleukin-6), and IL-8 (interleukin- 8) were determined by ELISA. The change in ROS (reactive oxygen species) was determined by fluorescence microscopy and ELISA. The levels of Toll-like receptor 2 (TLR2) andMAPK family proteins and NF-B signaling were determined by Western blot analysis. S. suis induced massive RAW264.7 cell death, a decline in bactericidal activity, the release of inflammatory cytokines, increased oxidative stress, and activation of TLR2/MAPK/NF-B signaling pathways. Mag treatment significantly suppressed macrophage cell death and caused a decline in bactericidal activity. Furthermore, Mag decreased inflammatory cytokines production and ROS generation. It also prevented p38, extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), inhibitor of NF-B (IB), and NF-B phosphorylation induced by S. suis in a dose-dependent manner. Our results indicate that Mag exerts anti-inflammatory and cell-protective effects and mediates the activation of MAPK and NF-B signaling by downregulating the expression of TLR2 upregulated by S. suis.
PMID: Int Immunopharmacol. 2018 Jun ;59:61-67. Epub 2018 Apr 5. PMID: 29627576 Abstract Title: Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice. Abstract: Magnolol, the main constituent of Magnolia officinalis, has been shown to produce antidepressant-like effect in rodents. Growing evidence shows that neuroinflammation, oxidative stress and neuroendocrine contribute to the pathogenesis of major depression. Here, the aim of this present study was to determine whether magnolol affected these systems in mice exposed to chronic mild stress (CMS). The ameliorative effect of magnolol on depressive-like symptoms was investigated through behavioral tests, including the classical sucrose preference and forced swimming tests. The behavioral evaluation showed that magnolol reversed the depressive-like deficits both in sucrose preference test and forced swimming test. The elevation of prefrontal cortex pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) was decreased by magnolol. Consistently, the microglia activation by CMS was also alleviated by magnolol. In addition, the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induced by CMS was attenuated by magnolol.Moreover, the increased lipid peroxidation such as malonaldehyde (MDA) and decreased antioxidant defense enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) induced by CMS were also reversed by magnolol. These findings suggest that administration of magnolol could alleviate depressive-like behaviors in CMS mice that are mediated by suppressing neuroinflammation and oxidative stress in the prefrontal cortex.
PMID: Int J Mol Sci. 2018 08 10 ;19(8). Epub 2018 Aug 10. PMID: 30103472 Abstract Title: Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer. Abstract: The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.
PMID: Front Pharmacol. 2018 ;9:357. Epub 2018 Apr 24. PMID: 29755347 Abstract Title: Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations. Abstract: Cisplatin is a potent anti-cancer drug that has been widely used in the treatment of various cancers; however, cisplatin administration results in severe nephrotoxicity and impedes its clinical applications. In this study, we showed that honokiol, a polyphenol constituent extracted fromexhibited a short-term protective effect against cisplatin-induced damages in renal epithelial cells. The protective effects of honokiol were resulted from the combination of (1) reduced cellular oxidative stress ranging from 53 to 32% reduction during a 24-h incubation, (2) the maintenance of cellular antioxidant capacity and (3) the stabilization of cytoskeletal structure of the kidney epithelial cells. By promoting the polymerization of actin (1.6-fold increase) and tubulin (1.8-fold increase) cytoskeleton, honokiol not only maintained epithelial cell morphology, but also stabilized cellular localizations of tight junction protein Occludin and adhesion junction protein E-Cadherin. With stabilized junction protein complexes and structural polymerized cytoskeleton network, honokiol preserved epithelial cell polarity and morphology and thus reduced cisplatin-induced cell disruption and damages. Our data demonstrated for the first time that honokiol could counteract with cisplatin-induced damages in renal epithelial cells, futurestudies would further validate the potential clinical application of honokiol in cisplatin-based cancer treatments with reduced nephrotoxicity.
PMID: Life Sci. 2018 Aug 15 ;207:184-204. Epub 2018 Jun 5. PMID: 29883720 Abstract Title: Proteomic analysis of honokiol-induced cytotoxicity in thyroid cancer cells. Abstract: AIMS: Honokiol is a natural product extracted from herbal plants such as the Magnolia species which have been shown to exhibit anti-tumor and anti-metastatic properties. However, the effects of honokiol on thyroid cancers are largely unknown.MATERIALS AND METHODS: To determine whether honokiol might be useful for the treatment of thyroid cancer and to elucidate the mechanism of toxicity of honokiol, we analyzed the impact of honokiol treatment on differential protein expression in human thyroid cancer cell line ARO using lysine-labeling two-dimensional difference gel electrophoresis (2D-DIGE) combined with mass spectrometry (MS).KEY FINDINGS: This study revealed 178 proteins that showed a significant change in expression levels and also revealed that honokiol-induced cytotoxicity in thyroid cancer cells involves dysregulation of cytoskeleton, protein folding, transcription control and glycolysis.SIGNIFICANCE: Our work shows that combined proteomic strategy provides a rapid method to study the molecular mechanisms of honokiol-induced cytotoxicity in thyroid cancer cells. The identified targets may be useful for further evaluation as potential targets in thyroid cancer therapy.
PMID: ACS Chem Neurosci. 2018 Jul 19. Epub 2018 Jul 19. PMID: 29989791 Abstract Title: Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2. Abstract: Honokiol (Hon), a polyphenol and main active ingredient from the bark of Magnolia officinalis, has been documented as having multiple pharmacological functions, including neuroprotection. However, the mechanisms underlying its neuroprotective effects are not well-defined. In this study, we reported that Hon attenuates the HO- or 6-hydroxydopamine (6-OHDA)-induced apoptosis of PC12 cells by increasing the glutathione level and upregulating a multitude of cytoprotective proteins, including heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, thioredoxin 1, and thioredoxin reductase 1. Further studies reveal that Hon promotes transcription factor Nrf2 nuclear translocation and activation. Moreover, the cytoprotection of Hon was antagonized by silence of Nrf2 expression, highlighting the fact that Nrf2 is critically engaged in the cellular functions of Hon. Taken together, our study identified that Hon is an effective agonist of Nrf2 in the neuronal system and displays potent neuroprotection against oxidative stress-mediated PC12 cell damage. These findings indicate that Hon is promising for further development as a therapeutic drug against oxidative stress-related neurodegenerative disorders.
PMID: J Pharmacol Exp Ther. 2018 Sep ;366(3):470-478. Epub 2018 Jul 10. PMID: 29991481 Abstract Title: Honokiol Ameliorates Amyloidosis and Neuroinflammation and Improves Cognitive Impairment in Alzheimer's Disease Transgenic Mice. Abstract: The present study examined the effects of honokiol on amyloid-(A)-induced cognitive impairment and the underlying mechanisms in APPswe/PS1dE9 transgenic mice. The results showed that honokiol administration (20 mg/kg per day, intraperitoneally) for 6 weeks effectively improved spatial memory deficits in APPswe/PS1dE9 transgenic mice. Honokiol significantly lowered Aproduction and senile plaque deposition by downregulating-site amyloid precursor protein cleavage enzyme 1 and enhancing Aphagocytosis by microglia. Honokiol reduced glial cell activation and the production of proinflammatory cytokines (TNF-, IL-1, and IL-6). Honokiol increased the transcriptional activity and protein levels of peroxisome proliferator-activated receptor-(PPARHowever, all of the beneficial effects of honokiol on pathologic changes, including biochemistry and cognitive function, could be blocked by GW9662, a specific PPARinhibitor. These findings suggested that honokiol may be a natural PPARagonist, acting to attenuate Ageneration and neuroinflammation. Therefore, honokiol may be a potential therapeutic approach for Alzheimer's disease.
By Dr. Mercola
The question posed in the headline is a common one heard by doctors everywhere: "How long does it take to have an empty stomach?" It's an important question for anyone taking prescription drugs because what you eat and drink, as well as the timing of your meals, can affect the way certain medications work.
Beyond that, there is value in becoming aware of the health benefits associated with regularly emptying your stomach. If your first thought, when you hear the words "empty stomach," is a negative one, it's time to update your thinking. Not only can you survive on an empty stomach, you can also thrive.
In my experience, emptying your stomach as a daily habit through intermittent fasting or another safe type of fasting can boost your health and well-being. The effects can be so radical that you actually may be able to reduce (or potentially eliminate) your use of prescription drugs as your health improves.
"Ask Well," a medical question and answer feature presented in The New York Times,1 recently fielded this inquiry: "Many medications should be taken on an empty stomach. How do you know when your stomach is empty?"
Dr. Richard Klasco, assistant professor of emergency medicine at the University of Colorado School of Medicine, who provided the answer, wrote, "Two hours after eating is a crude rule of thumb. A more accurate answer depends on the drugs you are taking and your medical conditions."2
Klasco goes on to note that research on gastric emptying the length of time it takes for your stomach to return to empty after a meal has been going on since the 1940s.
Over the years, the experiments have changed based on scientific and medical advances. Since 1966, nuclear medicine, which involves the use of a small amount of radioactive material to emit photon energy, has remained as the established standard for measuring gastric emptying. Says Klasco:3
"Standards for such testing have been set by the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. They state that a normal stomach should be 90 percent empty after four hours.4
The difference between this standard and the earlier study probably reflects differences in foods. Solids take longer to digest than liquids; fats take longer to digest than protein or ca...
Moringa oleifera may have been unfamiliar to some Americans until recently, but it's actually been used as a traditional herbal medicine for centuries. In fact, it's been mentioned in the Annals of Ayurvedic Medicine, one of the world's oldest medical systems, as a cure for over 300 diseases.1
One of the ways to harness the benefits of Moringa is by steeping its leaves in hot water to create an energizing tea that provides a wide array of nutrients. Continue reading this article to learn more about the benefits of Moringa tea, its nutritional profile and the ways you can make it at home.
Moringa tea comes from the leaves of Moringa oleifera, a tree that's native to the sub-Himalayan regions of India, Pakistan, Bangladesh and Afghanistan, but is now commonly grown in various tropical and subtropical areas around the world.2
Also known as "horseradish tree" and "drumstick tree," Moringa has been dubbed as a "miracle tree" because of its potential medicinal properties. It also earned the superfood status, thanks to its extensive nutritional content, which you may still obtain even after brewing its leaves into tea. Some of these nutrients include:3
Flavonoids (such as quercetin and kaempferol)
To make Moringa tea, the freshly harvested leaves are dried at room temperature to retain their valuable nutrients before they're crushed, powdered or shredded into loose pieces.4 These loose Moringa leaves may be steeped as is or placed into tea bags. In terms of flavor, pure Moringa leaf tea is said to have a slightly "green" or earthy taste, though it lacks the bitterness of kale or spiciness of arugula.5,6
The health benefits of Moringa oleifera tea are attributed to its rich nutritional profile. A lot of these benefits are not just backed by traditional beliefs, but also are supported by scientific research....
Can vaccines trigger autism? This is the topic of the film "Vaxxed: From Cover-Up to Catastrophe,"1 directed by Andrew Wakefield and produced by Del Bigtree, an Emmy Award-winning producer of "The Doctors" talk show.
The film became the center of controversy when it was pulled from the Tribeca Film Festival lineup in 2016 by Robert De Niro and Jane Rosenthal, the two founders of the well-known film festival. According to Rosenthal, other filmmakers had threatened to withdraw their films from the festival if "Vaxxed" was shown.
While De Niro admitted feeling pressured to pull the film, he urged people to see it, saying there are many issues relating to the way the U.S. Centers for Disease Control and Prevention (CDC) evaluates and monitors the safety of vaccines that are not being openly spoken about, and really should be addressed.
The official stance repeated by most mainstream media is that vaccines have been thoroughly researched, that "hundreds" of studies have proven their safety, and that no link between vaccines and health problems, such as autism, have ever been found.
Again and again, you hear that the autism-vaccine link was based on a single study published in 1998 by a now-discredited doctor (Wakefield), and the hypothetical association between vaccines and autism has since been thoroughly and repeatedly debunked. It sounds definitive enough, and is often repeated as established fact. Yet it's far from the whole truth.
Importantly, the vaccine industry has long shied away from evaluating vaccinated versus unvaccinated populations to determine potential differences in general health outcomes. The few independent scientists who have attempted such an investigation have little comfort to give to those who believe vaccines are essential for health, and mandatory use of vaccines by all children is the only way to protect society from disease.
One such study,2 published just last year, examined health outcomes among infants 3 to 5 months old following the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine in Guinea-Bissau, which took place in the early 1980s. This population offered the rare opportunity to compare vaccinated and...
PMID: Pak J Pharm Sci. 2018 Jul ;31(4):1279-1284. PMID: 30033411 Abstract Title: Oral administration of honokiol attenuates airway inflammation in asthmatic mouse model. Abstract: Allergic asthma is a disease that pathologically characterized by eosinophilia infiltration, airway inflammation and hyper responsiveness. In this study, we evaluated the anti-inflammatory and anti-allergy possibilities of honokiol, a bi-phenolic compound obtained from species of the genus Magnolia, which has long been involved in traditional Chinese prescriptions for asthma-related lung diseases, in an ovalbumin-induced mouse model of allergic asthma. We found honokiol significantly inhibited the eosinophilia infiltration, reduced the airway inflammation and suppressed the production of inflammatory cytokines) as well as the IgE in serum. Moreover, MMP-9 and? (IL-4 and IFN- NF-B were found to be involved in the honokiol induced biological process. These results suggested that honokiol may be a possible candidate in the treatment of lung asthma related diseases.
PMID: Artif Cells Nanomed Biotechnol. 2018 Jul 25:1-16. Epub 2018 Jul 25. PMID: 30043652 Abstract Title: Functional paclitaxel plus honokiol micelles destroying tumour metastasis in treatment of non-small-cell lung cancer. Abstract: Treatment effect of chemotherapy for aggressive non-small-cell lung cancer (NSCLC) is usually unsatisfactory for non-selective distributions of anticancer drugs, generation of vasculogenic mimicry (VM) channels, high metastasis and recurrence rate. Therefore, we developed a kind of dequalinium (DQA) modified paclitaxel plus honokiol micelles in this study to destroy VM channels and inhibit tumour metastasis. In vitro assays indicated that the targeting paclitaxel micelles with ideal physicochemical characteristics could exhibit not only the powerful cytotoxicity on Lewis lung tumour (LLT) cells but also the effective suppression on VM channels and tumour metastasis. Action mechanism studies manifested that DQA modified paclitaxel plus honokiol micelles could activate apoptotic enzymes caspase-3 and caspase-9 as well as down-regulate FAK, PI3K, MMP-2 and MMP-9. In vivo assays indicated that polymeric micelles could increase selective accumulation of chemotherapeutic drugs at tumour sites and showed a conspicuous antitumour efficacy. Hence, the DQA modified paclitaxel plus honokiol micelles prepared in this study provided a potential treatment strategy for NSCLC.
PMID: Environ Toxicol. 2018 Aug 4. Epub 2018 Aug 4. PMID: 30076764 Abstract Title: Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling. Abstract: Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide with poor prognosis. Numerous studies have attempted to explore alternative regimens aimed at reducing cancer stem cells (CSCs) without compromising the efficacy of conventional chemoradiotherapy. The present study sought to assess the effect of a natural compound honokiol on the reduction of elevated cancer stemness, metastatic capacity, and chemoresistance of oral carcinoma stem cells (OCSCs). Our results demonstrated that honokiol attenuated the cell survival and self-renewal of OCSCs in a dose-dependent manner. Moreover, honokiol downregulated the expression of 2 selective markers of OCSCs, ALDH1, and CD44, as well as the migration and invasion abilities, indicating its potential to suppress cancer stemness. We showed that honokiol reduced the secretion of IL-6 and phosphorylation of STAT3, and the honokiol-inhibited self-renewal, invasion and colony formation were reversed by administration of IL-6. Most importantly, our data demonstrated that honokiol was able to potentiate the effect of Cisplatin, leading to a lower proportion of OCSCs and the decreased cancer stemness features. Taken together, this study demonstrated the benefits of utilizing honokiol as an adjunct therapy for OSCC treatment.
PMID: Exp Ther Med. 2018 Aug ;16(2):1278-1284. Epub 2018 Jun 14. PMID: 30116378 Abstract Title: Protective effects of honokiol against oxidative stress-induced apoptotic signaling in mouse podocytes treated with H2O2. Abstract: Honokiol (HNK), an important bioactive compound purified from, has been demonstrated to have manifold beneficial anti-oxidative, anti-inflammatory, anti-bacterial and antitumor pharmacological effects. In the present study, the association of HNK in the signaling mechanism associated with hydrogen peroxide (HO)-induced apoptosis of cultured mouse podocytes was investigated. HNK did not cause significant changes in podocyte viability when its concentration remained below 20M. MTS assay and flow cytometry confirmed that HOsignificantly enhanced the rates of apoptosis while produce significant reduction in viability of podocytes. Following 24 h of pre-treatment with different concentrations of HNK, the viability of adherent podocytes increased and apoptosis significantly decreased in a dose-dependent manner below 20M. Reverse transcription-polymerase chain reaction and western blot results indicated that HNK significantly decreased the expression of mRNA and cleaved protein of caspase-3 and caspase-9 in podocytes pre-treated with HO. Furthermore, phosphorylation of the signaling molecules protein kinase B (Akt) and extracellular signal-regulated kinase (Erk) 1/2 appeared to increase following HNK treatment. In conclusion, HNK largely eliminated the role of promoting podocyte apoptosis in an oxidative stress environment, which was a protective factor on podocytes cultured with HO. The anti-oxidative stress mechanisms of HNK are partly due to suppressing the expression of caspase-3 and caspase-9 and upregulating phosphorylated-Akt and -Erk 1/2.
PMID: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Jul 28 ;43(7):718-724. PMID: 30124206 Abstract Title: [Effects of honokiol on particulate matter 2.5-induced lung injury in asthmatic mice and its mechanisms]. Abstract: To explore the therapeutic effect of honokiol on particulate matter 2.5 (PM2.5)-induced lung injury in asthmatic mice and the possible mechanisms. Methods: A total of 32 BALB/C mice were randomly divided into four groups: a normal saline group, a model group, a PM2.5 group and a honokiol group (n=8 in each group). The asthma mouse model was established by ovalbumin treatment. The mice were treated with physiological saline, ovalbumin, PM2.5 and honokiol, respectively. Lung tissues and serum were collected. The pathological changes of lung tissues were evaluated. The levels of inflammatory cytokines in bronchoalveolar lavage fluid (BALF) and serum were measured and the expressions of Toll like receptor 4 (TLR4), nuclear factor kappa B(NF-B), retinoid-related orphan receptor gamma-t (RORt) and forkhead box protein 3 (Foxp3) in lung tissues were detected. Results: 1) The lung tissues of mice in the asthma group showed obvious pathological changes and inflammatory state, suggesting that the asthma model was established successfully. PM2.5 could aggravate the pathological condition of inflammatory injury in lung tissues in asthmatic mice. 2) Compared to the PM2.5 group, the pathological symptoms in the lung tissues were alleviated in the honokiol group and the percentage of inflammatory cells in BALF and the levels ofinflammatory cytokines in BALF and serum were significantly reduced (all P
PMID: Life Sci. 2018 Oct 1 ;210:86-95. Epub 2018 Aug 29. PMID: 30171880 Abstract Title: Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis. Abstract: AIMS: Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inflammation and oxidative stress. However, whether HKL has protective effects against the dysfunction of pulmonary microvascular endothelial barrier and the potential mechanisms remain unclear.MAIN METHODS: In the present study, we examined the levels of plasma Angiopoietin-2 (Ang-2) in ARDS patients, explored the effects of HKL on the vascular endothelial barrier at the ARDS animal and cell levels.KEY FINDINGS: Our data showed that compared with the healthy controls, circulating Ang-2 level was higher in the patients with ARDS, and were usually supposed to be positively related to the severity of ARDS. Moreover, HKL effectively inhibited lung inflammatory injury and microvascular leakage, and improved ARDS mice survival. HKL also inhibited the expression of Ang-2, ICAM-1 and VCAM-1, and restored the expression of Sirt3,-Catenin and VE-Cadherin. Furthermore, HKL improved ECs survival and inhibited the apoptosis of ECs. The inhibition of Ang-2 expression in vitro by HKL is accompanied by the upregulation of Sirt3 and AMPK phosphorylation.SIGNIFICANCE: Our data demonstrated that HKL protected pulmonary microvascular endothelial barrier against LPS-induced ARDS at least in part through activating the Sirt3/AMPK signaling and inhibiting the Ang-2 expression. Thus, our findings show that the activation of Sirt3 signaling is a potential mechanism for the protective effects of HKL on vascular barrier.
PMID: J Neuroimmunol. 2018 Oct 15 ;323:78-86. Epub 2018 Jul 25. PMID: 30196838 Abstract Title: Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes. Abstract: Honokiol has been used in traditional medicine for the treatment of inflammatory diseases. Activation of glial cells plays an essential role in neurodegenerative disorders. In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes through the inhibition of pro-inflammatory mediators (iNOS, IL-6, IL-1 and TNF-) and the simultaneous stimulation of anti-inflammatory cytokines (IL-10). Expression of KLF4 was induced in microglia and astrocytes after treatment with LPS and this response was mitigated by Honokiol. These findings extend our understanding of the anti-inflammatory properties of Honokiol on central glial cells and support its use as a therapeutic compound in neuroinflammatory disorders.
PMID: Phytomedicine. 2018 Oct 1 ;49:41-51. Epub 2018 Aug 8. PMID: 30217261 Abstract Title: Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway. Abstract: BACKGROUND: Temozolomide (TMZ) is a first-line chemotherapeutic drug for malignant gliomas. Nonetheless, TMZ-induced side effects and drug resistance remain challenges. Our previous study showed the suppressive effects of honokiol on growth of gliomas.PURPOSE: This study was further aimed to evaluate if honokiol could enhance TMZ-induced insults toward malignant glioma cells and its possible mechanisms.METHODS: Human U87 MG glioma cells were exposed to TMZ, honokiol, and a combination of TMZ and honokiol. Cell survival, apoptosis, necrosis, and proliferation were successively assayed. Fluorometric substrate assays were conducted to determine activities of caspase-3, -6, -8, and -9. Levels of Fas ligand, Bax, and cytochrome c were immunodetected. Translocation of Bax to mitochondria were examined using confocal microscopy. Mitochondrial function was evaluated by assaying the mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and complex I enzyme activity. Caspase-6 activity was suppressed using specific peptide inhibitors. The honokiol-induced effects were further confirmed using human U373 MG and murine GL261 cells.RESULTS: Exposure of human U87 MG glioma cells to honokiol significantly increased TMZ-induced DNA fragmentation and cell apoptosis. Interestingly, honokiol enhanced intrinsic caspase-9 activity without affecting extrinsic Fas ligand levels and caspase-8 activity. Sequentially, TMZ-induced changes in Bax translocation, the MMP, mitochondrial complex I enzyme activity, intracellular ROS levels, and cytochrome c release were enhanced by honokiol. Consequently, honokiol amplified TMZ-induced activation of caspases-3 and -6 in human U87 MG cells. Fascinatingly, suppressing caspase-6 activity concurrently decreased honokiol-induced DNA fragmentation and cell apoptosis. The honokiol-involved improvement in TMZ-induced intrinsic apoptosis was also confirmed in human U373 MG and murine GL261 glioma cells.CONCLUSIONS: This study showed that honokiol can enhance TMZ-induced apoptotic insults to glioma cells via an intrinsic mitochondrion-dependent mechanism. Our results suggest the therapeutic potential of honokiol to attenuate TMZ-induced side effects.
PMID: Oncol Rep. 2018 Oct 1. Epub 2018 Oct 1. PMID: 30272350 Abstract Title: Mangiferin induces radiosensitization in glioblastoma cells by inhibiting nonhomologous end joining. Abstract: Although surgery and highdose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA doublestrand break (DSB) repair serves a critical role in resistance to radiotherapy. Previous studies have revealed that mangiferin possesses antineoplastic effects on human lung adenocarcinoma and ovarian cancer. The present study aimed to investigate the role of mangiferin in radiosensitivity inhuman GBM. Through in vitro experiments, decreased proliferation and increased DNA damage were observed in cells pretreated with mangiferin following radiation. Further study of the repair pathway indicated that mangiferin inhibits the nonhomologous endjoining (NHEJ) DSB repair pathway. Furthermore, studies on key proteins in the NHEJ DSB repair pathway revealed that mangiferininhibited the phosphorylation of serineprotein kinase ATM, TP53binding protein 1 and histone H2AX (H2AX). In addition, observations on the average percentages of H2AXpositive cells and the average number of H2AX foci per cell suggested that treatment with mangiferin decreased the number of H2AX foci in GBM cells following radiation. However, mangiferin selectively inhibited DSB repair in GBM cells, and was not able to trigger DSB repair inhibition in normal neuronal Schwann cells. Through in vivo tumorbearing mouse experiments, a smaller tumor volume, decreased tumor weight and prolonged life span were observed in mice treated with mangiferin following radiation. Therefore, xenograft GBM models clearly demonstrated that treatment with mangiferin treatment may increase tumor sensitivity to radiotherapy. Taken together, as demonstrated by in vivo and in vitro data, mangiferin may be a potential novel therapeutic drug for improving the radiation sensitivity of glioblastoma.
PMID: Mol Med Rep. 2018 Oct 2. Epub 2018 Oct 2. PMID: 30280187 Abstract Title: Mangiferin: An effective therapeutic agent against several disorders (Review). Abstract: Mangiferin (1,3,6,7tetrahydroxyxanthoneC2Dglucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, antihyperuricemic,neuroprotective, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several healthendorsing properties and is a promising candidate for further research and development. However, low solubility, mucosal permeability and bioavailability restrict the development of mangiferin as a clinical therapeutic, and chemical and physical modification is required to expand its application. This review comprehensively analyzed and collectively summarized the primary pharmacological actions of mangiferin that have been demonstrated in the literature, to support the potential future development of mangiferin as a novel therapeutic drug.
PMID: Cancer Res. 2018 Sep 25. Epub 2018 Sep 25. PMID: 30254147 Abstract Title: Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Abstract: Chemoradiation therapy is the mainstay for treatment of locally advanced, borderline resectable pancreatic cancer. Pharmacological ascorbate (P-AscH-, i.e., intravenous infusions of ascorbic acid, vitamin C), but not oral ascorbate, produces high plasma concentrations capable of selective cytotoxicity to tumor cells. In doses achievable in humans, P-AscH- decreases the viability and proliferative capacity of pancreatic cancer via a hydrogen peroxide (H2O2)-mediated mechanism. In this study, we demonstrate that P-AscH- radiosensitizes pancreatic cancer cells but inhibits radiation-induced damage to normal cells. Specifically, radiation-induced decreases in clonogenic survival and double-stranded DNA breaks in tumor cells, but not in normal cells, were enhanced by P-AscH-, while radiation-induced intestinal damage, collagen deposition, and oxidative stress were also reduced with P-AscH- in normal tissue. We also report on our first-in-human phase 1 trial that infused P-AscH- during the radiation therapy 'beam on.' Specifically, treatment with P-AscH- increased median overall survival compared to our institutional average (21.7 vs. 12.7 mo, p = 0.08) and the E4201 trial (21.7 vs. 11.1 mo). Progression-free survival in P-AscH--treated subjects was also greater than our institutional average (13.7 vs. 4.6 mo, p
PMID: Biochem Soc Trans. 2018 Oct 8. Epub 2018 Oct 8. PMID: 30301842 Abstract Title: Vitamin C and immune cell function in inflammation and cancer. Abstract: Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many aspects of the immune response. Intracellular levels generally respond to variations in plasma ascorbate availability, and a combination of inadequate intake and increased turnover during severe stress can result in low plasma ascorbate status. Intracellular ascorbate supports essential functions and, in particular, acts as an enzyme cofactor for Fe- or Cu-containing oxygenases. Newly discovered enzymes in this family regulate cell metabolism and epigenetics, and dysregulation of their activity can affect cell phenotype, growth and survival pathways, and stem cell phenotype. This brief overview details some of the recent advances in our understanding of how ascorbate availability can affect the hydroxylases controlling the hypoxic response and the DNA and histone demethylases. These processes play important roles in the regulation of the immune system, altering cell survival pathways, metabolism and functions.
PMID: Crit Care. 2018 Oct 11 ;22(1):258. Epub 2018 Oct 11. PMID: 30305111 Abstract Title: Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis. Abstract: Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary extends both reviews by integrating a meta-analysis and sharing aggregated results. Pooled analyses demonstrated a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C.
PMID: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Jun ;23(3):163-6. PMID: 16124885 Abstract Title: [Influence of 1.8 GHz microwave on DNA damage induced by 4 chemical mutagens]. Abstract: OBJECTIVE: To observe the influence of 1.8 GHz microwave (MW) specific absorption rate (SAR, 3 W/kg) on human lymphocytes DNA damage induced by 4 chemical mutagens [mitomycin C (MMC), bleomycin (BLM), methyl methanesulfonate (MMS), and 4-nitroquinoline 1-oxide (4NQO)].METHODS: Comet assay in vitro was used to detect human lymphocyte DNA damage induced by 1.8 GHz MW, 4 chemical mutagens, and MW plus 4 chemicals 0 h and 21 h respectively after exposure. The time exposed to MW or mutagens was 2 h or 3 h respectively. The results were showed by tail length (TL) and tail moment (TM).RESULTS: The difference of DNA damage between MW group and control group was not statistically significant (P>0.05). DNA damages in MW plus MMC groups and MW plus 4NQO groups were significantly greater than those in the corresponding concentrations of MMC groups and 4NQO groups (P
PMID: Cell Biochem Biophys. 2010 ;56(1):39-47. PMID: 19851891 Abstract Title: The influence of 1800 MHz GSM-like signals on hepatic oxidative DNA and lipid damage in nonpregnant, pregnant, and newly born rabbits. Abstract: The aim of our study is to evaluate the possible biological effects of whole-body 1800 MHz GSM-like radiofrequency (RF) radiation exposure on liver oxidative DNA damage and lipid peroxidation levels in nonpregnant, pregnant New Zealand White rabbits, and in their newly borns. Eighteen nonpregnant and pregnant rabbits were used and randomly divided into four groups which were composed of nine rabbits: (i) Group I (nonpregnant control), (ii) Group II (nonpregnant-RF exposed), (iii) Group III (pregnant control), (iv) Group IV (pregnant-RF exposed). Newborns of the pregnant rabbits were also divided into two groups: (v) Group V (newborns of Group III) and (vi) Group VI (newborns of Group III). 1800 MHz GSM-like RF radiation whole-body exposure (15 min/day for a week) was applied to Group II and Group IV. No significant differences were found in liver 8 OHdG/10(6) dG levels of exposure groups (Group II and Group IV) compared to controls (Group I and Group III). However, in Group II and Group IV malondialdehyde (MDA) and ferrous oxidation in xylenol orange (FOX) levels were increased compared to Group I (P0.05, Mann-Whitney) while liver FOX levels were found significantly increased in Group VI with respect to Group V (P
PMID: Medicine (Baltimore). 2018 Aug ;97(34):e11918. PMID: 30142802 Abstract Title: Whole-body vibration training and bone health in postmenopausal women: A systematic review and meta-analysis. Abstract: BACKGROUND: The aims of the present systematic review and meta-analysis were to evaluate published, randomized controlled trials that investigate the effects on whole-body vibration (WBV) training on total, femoral neck, and lumbar spine bone mineral density (BMD) in postmenopausal women, and identify the potential moderating factors explaining the adaptations to such training.METHODS: From a search of electronic databases (PubMed, Web of Science, and Cochrane) up until September 2017, a total 10 studies with 14 WBV groups met the inclusion criteria. Three different authors tabulated, independently, the selected indices in identical predetermined forms. The methodological quality of all studies was evaluated according to the modified PEDro scale. For each trial, differences within arms were calculated as mean differences (MDs) and their 95% confidence intervals between pre- and postintervention values. The effects on bone mass between exercise and control groups were also expressed as MDs. Both analyses were performed in the total sample and in a specific class of postmenopausal women younger than 65 years of age (excluding older women).RESULTS: The BMD of 462 postmenopausal women who performed WBV or control protocol was evaluated. Significant pre-post improvements in BMD of the lumbar spine were identified following WBV protocols (P=.03). Significant differences in femoral neck BMD (P=.03) were also found between intervention and control groups when analyzing studies that included postmenopausal women younger than 65 years.CONCLUSIONS: WBV is an effective method to improve lumbar spine BMD in postmenopausal and older women and to enhance femoral neck BMD in postmenopausal women younger than 65 years.
PMID: Int J Mol Sci. 2018 Sep 13 ;19(9). Epub 2018 Sep 13. PMID: 30217051 Abstract Title: Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats. Abstract: A risk of ischemic stroke increases exponentially after menopause. Even a mild-ischemic stroke can result in increased frailty. Frailty is a state of increased vulnerability to adverse outcomes, which subsequently increases risk of cerebrovascular events and severe cognitive decline, particularly after menopause. Several interventions to reduce frailty and subsequent risk of stroke and cognitive decline have been proposed in laboratory animals and patients. One of them is whole body vibration (WBV). WBV improves cerebral function and cognitive ability that deteriorates with increased frailty. The goal of the current study is to test the efficacy of WBV in reducing post-ischemic stroke frailty and brain damage in reproductively senescent female rats. Reproductively senescent Sprague-Dawley female rats were exposed to transient middle cerebral artery occlusion (tMCAO) and were randomly assigned to either WBV or no-WBV groups. Animals placed in the WBV group underwent 30 days of WBV (40 Hz) treatment performed twice daily for 15 min each session, 5 days each week. The motor functions of animals belonging to both groups were tested intermittently and at the end of the treatment period. Brains were then harvested for inflammatory markers and histopathological analysis. The results demonstrate a significant reduction in inflammatory markers and infarct volume with significant increases in brain-derived neurotrophic factor and improvement in functional activity after tMCAO in middle-aged female rats that were treated with WBV as compared to the no-WBV group. Our results may facilitate a faster translation of the WBV intervention for improved outcome after stroke, particularly among frail women.
By Zack Perdue
When most people smoke cannabis, its effects are felt a few minutes later thanks to the psychoactive ingredient, THC. Yet, to feel the non-psychoactive substance in cannabis, specifically cannabidiol or CBD, a person may need to take several doses. Therefore, you may be wondering: what is the most effective and quickest way to reap the natural benefits of CBD oil?
Before answering this question, it is important to recognize that each person is different. Everyones biology is different, making it difficult to pinpoint exactly how each person can get CBD oil to work quickly. How you take CBD oil, your age, health, genetic makeup, metabolism, and tolerance can all have an influence on how quickly your body responds to CBD oil.
However, science has found several ways that CBD oil typically works faster in most people. Check them out below.
The fastest way to feel the effects of CBD oil is to get it into your bloodstream. When CBD oil enters the bloodstream, it begins working with the endocannabinoid system nearly immediately. This is the simplest explanation for getting CBD oil to work faster. However, it is important to understand the different ways to administer CBD oil so it efficiently ent...
PMID: J Cosmet Laser Ther. 2018 Oct 9:1-8. Epub 2018 Oct 9. PMID: 30300017 Abstract Title: Whole-body vibration in the reduction of the cellulite. Abstract: OBJECTIVE: Evaluate the effects of the whole body vibration in improving of cellulite in the women's gluteal region.METHODS: Controlled clinical trial performed with 42 women, with cellulite in the gluteal region, detected by means of clinical examination. After evaluation, the women were divided into two groups: Whole-Body Vibration (WBV_G) and control (C_G). The evaluations were performed at the beginning and the end of 10 sessions and superficial skin temperature, perimetry in the gluteal region, analysis of body contouring, analysis of improvement by blind reviewers and instrument of satisfaction, by numeric scale were investigated.RESULTS: In the thermographic analysis, the WBV_G obtained significant increase of superficial skin temperature on the right (p = 0.02) and left (p = 0.02) gluteal region. There was no difference in intra- and intergroups in perimetry and the analysis of body contour. The WBV_G obtained a higher percentage of improvement by assessment of the blind reviewers (p = 0.003) and greater aesthetics satisfaction (p = 0.006), when compared to C_G.CONCLUSION: WBV provided an improvement in the aspect of the cellulite when assessed by blind reviewers and greater participants' satisfaction, providing a significant increase in the superficial skin temperature in the gluteal region.
By Carey Wedler
California state lawmakers recently passed a bill forcing restaurants to offer specific beverages to children. Governor Jerry Brown signed the legislation, which passed easily in both the Senate and Assembly, at the end of September.
Though SB 1192 allows customers to order other drinks upon request, the Golden State is now mandating that only unflavored milk and water be listed as default beverages on menus (a provision also allows for non-dairy fluid milk substitutes containing under 130 calories).
According to the new law, violations of the rule will be punishable by fines up to $500:
[The] first violation shall result in a notice of violation. A second violation within a five-year period from the notice of violation shall be punishable by a fine of not more than two hundred fifty dollars ($250). For a third or subsequent violation within a five-year period, the fine shall be not more than five hundred dollars ($500).
As with most government policies that restrict individual and economic freedom, lawmakers appealed to the pu...
PMID: Biomed Environ Sci. 2010 Jun ;23(3):199-207. PMID: 20708499 Abstract Title: Effects of exposure to GSM mobile phone base station signals on salivary cortisol, alpha-amylase, and immunoglobulin A. Abstract: OBJECTIVE: The present study aimed to test whether exposure to radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phone base stations may have effects on salivary alpha-amylase, immunoglobulin A (IgA), and cortisol levels.METHODS: Fifty seven participants were randomly allocated to one of three different experimental scenarios (22 participants to scenario 1, 26 to scenario 2, and 9 to scenario 3). Each participant went through five 50-minute exposure sessions. The main RF-EMF source was a GSM-900-MHz antenna located at the outer wall of the building. In scenarios 1 and 2, the first, third, and fifth sessions were"low"(median power flux density 5.2 microW/m(2)) exposure. The second session was"high"(2126.8 microW/m(2)), and the fourth session was"medium"(153.6 microW/m(2)) in scenario 1, and vice versa in scenario 2. Scenario 3 had four"low"exposure conditions, followed by a"high"exposure condition. Biomedical parameters were collected by saliva samples three times a session. Exposure levels were created by shielding curtains.RESULTS: In scenario 3 from session 4 to session 5 (from"low"to"high"exposure), an increase of cortisol was detected, while in scenarios 1 and 2, a higher concentration of alpha-amylase related to the baseline was identified as compared to that in scenario 3. IgA concentration was not significantly related to the exposure.CONCLUSIONS: RF-EMF in considerably lower field densities than ICNIRP-guidelines may influence certain psychobiological stress markers.
PMID: Cell Biochem Biophys. 2013 Nov ;67(2):743-51. PMID: 23526187 Abstract Title: Effects of prenatal and postnatal exposure to GSM-like radiofrequency on blood chemistry and oxidative stress in infant rabbits, an experimental study. Abstract: We aimed to investigate the potential hazardous effects of prenatal and/or postnatal exposure to 1800 MHz GSM-like radiofrequency radiation (RFR) on the blood chemistry and lipid peroxidation levels of infant rabbits. A total of 72 New Zealand female and male white rabbits aged 1-month were used. Thirty-six female and 36 male were divided into four groups which were composed of nine infants: (i) Group 1 were the sham exposure (control), (ii) Group 2 were exposed to RFR, 15 min daily for 7 days in the prenatal period (between 15th and 22nd days of the gestational period) (prenatal exposure group). (iii) Group 3 were exposed to RFR 15 min/day (14 days for male, whereas 7 days for female)after they reached 1-month of age (postnatal exposure group). (iv) Group 4 were exposed to RFR for 15 min daily during 7 days in the prenatal period (between 15th and 22nd days of the gestational period) and 15 min/day (14 days for male, whereas 7 days for female) after they reached 1-month ofage (prenatal and postnatal exposure group). Results showed that serum lipid peroxidation level in both female and male rabbits changed due to the RFR exposure. However, different parameters of the blood biochemistry were affected by exposure in male and female infants. Consequently, the whole-body1800 MHz GSM-like RFR exposure may lead to oxidative stress and changes on some blood chemistry parameters. Studies on RFR exposure during prenatal and postnatal periods will help to establish international standards for the protection of pregnants and newborns from environmental RFR.
PMID: Electromagn Biol Med. 2014 Sep ;33(3):216-22. Epub 2013 Jun 19. PMID: 23781998 Abstract Title: Long-term effects of 900MHz radiofrequency radiation emitted from mobile phone on testicular tissue and epididymal semen quality. Abstract: The purpose of this study is to bridge this gap by investigating effects of long term 900MHz mobile phone exposure on reproductive organs of male rats. The study was carried out on 14 adult Wistar Albino rats by dividing them randomly into two groups (n: 7) as sham group and exposure group. Rats were exposed to 900MHz radiofrequency (RF) radiation emitted from a GSM signal generator. Point, 1g and 10g specific absorption rate (SAR) levels of testis and prostate were found as 0.0623W/kg, 0.0445W/kg and 0.0373W/kg, respectively. The rats in the exposure group were subject to RF radiation 3h per day (7d a week) for one year. For the sham group, the same procedure was applied, except the generator was turned off. At the end of the study, epididymal sperm concentration, progressive sperm motility, abnormal sperm rate, all-genital organs weights and testis histopathology were evaluated. Any differences were not observed in sperm motility and concentration (p>0.05). However, the morphologically normal spermatozoa rates were found higher in the exposure group (p
PMID: J Biomed Phys Eng. 2015 Sep ;5(3):105-14. Epub 2015 Sep 1. PMID: 26396966 Abstract Title: Effect of 900 MHz Electromagnetic Radiation on the Induction of ROS in Human Peripheral Blood Mononuclear Cells. Abstract: BACKGROUND: Despite numerous studies over a decade, it still remains controversial about the biological effects of RF EMF emitted by mobile phone telephony.OBJECTIVE: Here we investigated the effect of 900 MHz GSM on the induction of oxidative stress and the level of intracellular reactive oxygen species (ROS) in human mononuclear cells, monocytes and lymphocytes as defence system cells.METHOD: 6 ml Peripheral Blood samples were obtained from 13 healthy volunteers (21-30 year-old). Each sample was devided into 2 groups: one was exposed RF radiation emitted from a mobile phone simulator for 2 hour and the other used as control group which was not exposed to any fields. After that, mononuclear cells were isolated from peripheral blood by density gradient centrifugation in Ficoll-Paque. The intracellular ROS content in monocytes and lymphocytes was measured by the CM-H2DCFDA fluorescence probe using flowcytometry technique.RESULTS: Our results showed significant increase in ROS production after exposure in population rich in monocytes. This effect was not significant in population rich in lymphocytes in comparison with non exposed cells.CONCLUSION: The results obtained in this study clearly showed the oxidative stress induction capability of RF electromagnetic field in the portion of PBMCs mostly in monocytes, like the case of exposure to micro organisms, although the advantages or disadvantages of this effect should be evaluated.
PMID: Int J Radiat Biol. 2016 ;92(1):1-10. Epub 2015 Dec 2. PMID: 26630175 Abstract Title: Activity and expression of acetylcholinesterase in PC12 cells exposed to intermittent 1.8 GHz 217-GSM mobile phone signal. Abstract: PURPOSE: Due to its role in learning, memory and in many neurodegenerative diseases, acetylcholinesterase (AChE) represents an interesting endpoint to assess possible targets of exposure to radiofrequency electromagnetic fields (RF-EMF) generated by mobile phones. We investigated possible alterations of enzymatic activity, gene and protein expression of AChE in neuronal-like cells exposed to a 1.8 GHz Global System for Mobile Communication (GSM) modulated signal (217-GSM).MATERIALS AND METHODS: Rat PC12 cells were exposed for 24 h to 1.8 GHz 217-GSM signal. Specific adsorption rate (SAR) was 2 W/kg. AChE enzyme activity was assessed spectrophotometrically by Ellman's method, mRNA expression level was evaluated by real time polymerase chain reaction, and protein expression was assessed by Western blotting.RESULTS: AChE enzymatic activity increased of 1.4-fold in PC12 cells exposed to 217-GSM signal for 24 h, whilst AChE transcriptional or translational pathways were not affected.CONCLUSION: Our results provide the first evidence of effects on AChE activity after in vitro exposure of mammalian cells to the RF-EMF generated by GSM mobile phones, at the SAR value 2 W/kg. The obtained evidence promotes further investigations on AChE as a possible target of RF-EMF and confirm the ability of 1.8 GHz 217-GSM signal to induce biological effects in different mammalian cells.
PMID: Ecotoxicol Environ Saf. 2016 Jul ;129:137-44. Epub 2016 Mar 24. PMID: 27017260 Abstract Title: Effects of GSM-like radiofrequency irradiation during the oogenesis and spermiogenesis of Xenopus laevis. Abstract: We aimed to evaluate the effect of GSM-like radiofrequency electromagnetic radiation (RF-EMR) on the oogenesis, and spermiogenesis of Xenopus laevis, and so the development of the embryos obtained from Normal Females+Normal Males (i.e."N(F)+N(M)"); Normal Females+RF-exposed Males (i.e."N(F)+RF(M)"); RF-exposed Female+Normal Male (i.e."RF(F)+N(M)"); and RF-exposed Female+RF-exposed Male (i.e."RF(F)+RF(M)". Various, assessments were performed to determine potential teratogenic effects and mortality, body growth and behavior on first generation embryos. After exposing adults frogs of both sexes to 900MHz RF-EMR (at 1.0W/kg) for 8h a day over a 5-week period, the embryos' specific energy absorption rate (SAR) was calculated. In our present study (control group; 2.2% abnormal, 0.0% dead); with the N(F)+RF(M) combination, the long-term exposure of adult males to GSM-like radiation at 900MHz (RF: 2W) for 5 week/8h/day resulted in normal, abnormal and dead embryo ratios of 88.3%, 3.3% and 8.3%, respectively (p
PMID: Bratisl Lek Listy. 2016 ;117(11):672-676. PMID: 28125894 Abstract Title: GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits. Abstract: BACKGROUND: There have been several Radio Frequency (RF) field researches on various populations and groups of different ages in recent years. However, the most important group for research has been declared as the pregnant women and their babies.OBJECTIVE: The aim of the study was to analyse the effect on apoptotic factors of RF fields on newborn rabbit liver tissues.MATERIALS AND METHODS: Cytochrome c and AIF (Apoptosis Inducing Factor) levels were measured by western blot and caspase 1, 3 and 9 activities were measured by colorimetric method.RESULTS: Cytochrome c and AIF levels were not altered, but all caspase activities were increased in female infant rabbits that exposed to 1800 MHz GSM-like RF signals when they reached 1 month of age and caspase 1 and caspase 3 levels were decreased in male infant rabbits that exposed to 1800 MHz GSM-like RF signals between 15th and 22nd days of the gestational period. Results showed that 1800 MHz GSM-like RF exposure might lead to apoptosis in infant rabbit's liver tissues.CONCLUSION: According to the results, we suggest that postnatal RF exposure causes caspase dependent apoptosis in female infant rabbits liver tissues (Tab. 1, Fig. 2, Ref. 27).
PMID: J Biomed Phys Eng. 2016 Dec ;6(4):243-252. Epub 2016 Dec 1. PMID: 28144594 Abstract Title: Effects of RF-EMF Exposure from GSM Mobile Phones on Proliferation Rate of Human Adipose-derived Stem Cells: An In-vitro Study. Abstract: BACKGROUND: As the use of mobile phones is increasing, public concern about the harmful effects of radiation emitted by these devices is also growing. In addition, protection questions and biological effects are among growing concerns which have remained largely unanswered. Stem cells are useful models to assess the effects of radiofrequency electromagnetic fields (RF-EMF) on other cell lines. Stem cells are undifferentiated biological cells that can differentiate into specialized cells. Adipose tissue represents an abundant and accessible source of adult stem cells. The aim of this study is to investigate the effects of GSM 900 MHz on growth and proliferation of mesenchymal stem cells derived from adipose tissue within the specific distance and intensity.MATERIALS AND METHODS: ADSCs were exposed to GSM mobile phones 900 MHz with intensity of 354.6W/cmsquare waves (217 Hz pulse frequency, 50% duty cycle), during different exposure times ranging from 6 to 21 min/day for 5 days at 20 cm distance from the antenna. MTT assay was used to determine the growth and metabolism of cells and trypan blue test was also done for cell viability. Statistical analyses were carried out using analysis of one way ANOVA. P
PMID: Neurotox Res. 2017 Oct ;32(3):444-459. Epub 2017 Jun 3. PMID: 28578480 Abstract Title: Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the Rat Cerebral Cortex. Abstract: Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 MHz could impact on a neuroinflammatory reaction triggered by lipopolysaccharide (LPS) in 2-week-old or adult rats. We focused on the cerebral cortex in which the specific absorption rate (SAR) of RF averaged 2.9 W/kg. In developing rats, 24 h after GSM exposure, the levels of cortical interleukin-1 (IL1) or NOX2 NADPH oxidase transcripts were reduced by 50 to 60%, in comparison with sham-exposed animals (SAR = 0), as assessed by RT-qPCR. Adult rats exposed to GSM also showed a 50% reduction in the level of IL1 mRNA, but they differed from developing rats by the lack of NOX2 gene suppression and by displaying a significant growth response of microglial cell processes imaged in anti-Iba1-stained cortical sections. As neuroinflammation is often associated with changes in excitatory neurotransmission, we evaluated changes in expression and phosphorylation of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the adult cerebral cortex by Western blot analyses. We found that GSM exposure decreased phosphorylation at two residues on the GluA1 AMPAR subunit (serine 831 and 845). The GSM-induced changes in gene expressions, microglia, and GluA1 phosphorylation did not persist 72 h after RF exposure and were not observed in the absence of LPS pretreatment. Together, our data provide evidence that GSM-1800 MHz can modulate CNS cell responses triggered by an acute neuroinflammatory state.
PMID: J Neurophysiol. 2018 Aug 22. Epub 2018 Aug 22. PMID: 30133383 Abstract Title: DECREASED SPONTANEOUS ELECTRICAL ACTIVITY IN NEURONAL NETWORKS EXPOSED TO RADIOFREQUENCY 1800 MHZ SIGNALS. Abstract: So far, the only identified biological effects of radiofrequency fields (RF) are known to be caused by heating but the issue of potential nonthermal biological effects, especially on the central nervous system (CNS), remains open. We previously reported a decrease in the firing and bursting rates of neuronal cultures exposed to a Global System for Mobile (GSM) RF field at 1800 MHz for 3 min (Moretti et al. 2013). The aim of the present work was to assess the dose-response relationship for this effect, and also identify a potential differential response elicited by pulse-modulated GSM and continuous-wave (CW) RF fields. Spontaneous bursting activity of neuronal cultures from rat embryonic cortices was recorded using 60-electrode Multi Electrode Arrays (MEAs). At 17-28 days in vitro, the neuronal cultures were subjected to 15-min RF exposures, at SARs (Specific Absorption Rates) ranging from 0.01 to 9.2 W/kg. Both GSM and CW signals elicited a clear decrease in bursting rate during the RF exposure phase. This effect became more marked with increasing SAR and lasted even beyond the end of exposure for the highest SAR levels. Moreover, the amplitude of the effect was greater with the GSM signal. Altogether, our experimental findings provide evidence for dose-dependent effects of RF signals on the bursting rate of neuronal cultures and suggest that part of the mechanism is nonthermal.
PMID: Brain Res. 2010 Jan 22 ;1311:189-96. Epub 2009 Oct 30. PMID: 19879861 Abstract Title: Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons. Abstract: Increasing evidence indicates that oxidative stress may be involved in the adverse effects of radiofrequency (RF) radiation on the brain. Because mitochondrial DNA (mtDNA) defects are closely associated with various nervous system diseases and mtDNA is particularly susceptible to oxidative stress, the purpose of this study was to determine whether radiofrequency radiation can cause oxidative damage to mtDNA. In this study, we exposed primary cultured cortical neurons to pulsed RF electromagnetic fields at a frequency of 1800 MHz modulated by 217 Hz at an average special absorption rate (SAR) of 2 W/kg. At 24 h after exposure, we found that RF radiation induced a significant increase in the levels of 8-hydroxyguanine (8-OHdG), a common biomarker of DNA oxidative damage, in the mitochondria of neurons. Concomitant with this finding, the copy number of mtDNA and the levels of mitochondrial RNA (mtRNA) transcripts showed an obvious reduction after RF exposure. Each of these mtDNA disturbances could be reversed by pretreatment with melatonin, which is known to be an efficient antioxidant in the brain. Together, these results suggested that 1800 MHz RF radiation could cause oxidative damage to mtDNA in primary cultured neurons. Oxidative damage to mtDNA may account for the neurotoxicity of RF radiation in the brain.
PMID: Int J Radiat Biol. 2018 Sep 27:1-8. Epub 2018 Sep 27. PMID: 30028652 Abstract Title: What is adverse effect of wireless local area network, using 2.45GHz, on the reproductive system? Abstract: AIM: To investigate the inflammatory effect and testicular damage on rats exposed to low level of electromagnetic fields (EMF) at 2.45GHz microwave radiation.METHODS: Twenty two Wistar rats were divided into two groups. Group 1 was the control group and not exposed to EMF. Group 2 was exposed to low level EMF (average E-field 3.680.36 V/m, whole body average SAR, 0.0233 W/kg, in 10g tissue) at 2.45GHz for 1hour/day for 30 consecutive days. At the end of the study, interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-32 (IL-32), C-reactive protein (CRP) were measured in rat serum and IL-6, IL-10, IL-32were measured in rat testis tissue. Furthermore, testicular tissues were evaluated histopathologically in terms of spermatogenesis and coagulation necrosis.RESULTS: Serum IL-6 and CRP levels were found to be significantly different in the study group compared to the control group (p.05). On the other hand, histopathological evaluation of testicular tissue revealed a significant difference in necrosis and spermatogenesis when compared with the control group (p
On Wednesday, we reported that a month after media reports of undisclosed conflicts of interest by top brass at Memorial Sloan Kettering Cancer Center, a researcher there had corrected two papers to include financial conflicts of interest. Today, The New York Times and ProPublica which had broken the original story about former chief medical Continue reading More than a dozen papers by Sloan Kettering researchers have now been updated with financial disclosures
by Paul Fassa
Health Impact News
Many of us are aware of the endocrine disrupting potential of BPA (bisphenol-A) used in many plastic containers and inner linings of cans that the food processors label BPA Free as a marketing device.
Unfortunately, the replacement chemical, BPS (biphenol-S) has been discovered with, at least, the same endocrine mimicking dangers or perhaps even worse effects on hormonal health than BPA.
This leads to conscientious consumers being duped into exposure from biphenol endocrine disruptors from containers labeled BPA Free if other bisphenols such as BPS are used. Those who arent duped have to deal with concerns about labels and do more research.
But theres one ubiquitous item that openly contains BPA in order for it to function, and that is ink-less printing paper. Thermal paper is used by almost all cash registers, ATMs, medical equipment, and other machines that offer printouts.
There have been concerns about skin exposure with BPA thermal paper and its consequences, and there are studies now confirming that handling these receipts are exposing our bodies to BPA toxicity even more than consuming food in BPA packaging.
A 2017 study discovered that skin contact with thermal paper is a pathway that leads to BPA in the body at higher levels and with longer residual effects than oral consumption of foods or beverages packaged in BPA plastic containers.
This study, Prolonged Exposure to Bisphenol A from Single Dermal Contact Events was published online by the journal Environmental Science and Technology on July 31, 2017.
Knowing that thermal paper is coated with BPA, the researchers were curious about the...
PMID: J Chem Neuroanat. 2016 09 ;75(Pt B):85-93. Epub 2015 Sep 12. PMID: 26371078 Abstract Title: The link between radiofrequencies emitted from wireless technologies and oxidative stress. Abstract: Wireless communication such as cellular telephones and other types of handheld phones working with frequencies of 900MHz, 1800MHz, 2100MHz, 2450MHz have been increasing rapidly. Therefore, public opinion concern about the potential human health hazards of short and long-term effect of exposure to radiofrequency (RF) radiation. Oxidative stress is a biochemical condition, which is defined by the imbalance between reactive oxygen species (ROS) and the anti-oxidative defense. In this review, we evaluated available in vitro and in vivo studies carried out on the relation between RF emitted from mobile phones and oxidative stress. The results of the studies we reviewed here indicated that mobile phones and similar equipment or radars can be thought as a factor, which cause oxidative stress. Even some of them claimed that oxidative stress originated from radiofrequencies can be resulted with DNA damage. For this reason one of the points to think on is relation between mobile phones and oxidative stress. However, more performance is necessary especially on human exposure studies.
PMID: Reproduction. 2016 12 ;152(6):R263-R276. Epub 2016 Sep 6. PMID: 27601711 Abstract Title: The effects of radiofrequency electromagnetic radiation on sperm function. Abstract: Mobile phone usage has become an integral part of our lives. However, the effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted by these devices on biological systems and specifically the reproductive systems are currently under active debate. A fundamental hindrance to the current debate is that there is no clear mechanism of how such non-ionising radiation influences biological systems. Therefore, we explored the documented impacts of RF-EMR on the male reproductive system and considered any common observations that could provide insights on a potential mechanism. Among a total of 27 studies investigating the effects of RF-EMR on the male reproductive system, negative consequences of exposure were reported in 21. Within these 21 studies, 11 of the 15 that investigated sperm motility reported significant declines, 7 of 7 that measured the production of reactive oxygen species (ROS) documented elevated levels and 4 of 5 studies that probed for DNA damage highlighted increased damage due to RF-EMR exposure. Associated with this, RF-EMR treatment reduced the antioxidant levels in 6 of 6 studies that discussed this phenomenon, whereas consequences of RF-EMR were successfully ameliorated with the supplementation of antioxidants in all 3 studies that carried out these experiments. In light of this, we envisage a two-step mechanism whereby RF-EMR is able to induce mitochondrial dysfunction leading to elevated ROS production. A continued focus on research, which aims to shed light on the biological effects of RF-EMR will allow us to test and assess this proposed mechanism in a variety of cell types.
PMID: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018 Jan 28 ;53(2):132-138. Epub 2017 Nov 17. PMID: 29148897 Abstract Title: Oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation. Abstract: The exact mechanism that could explain the effects of radiofrequency (RF) radiation exposure at non-thermal level is still unknown. Increasing evidence suggests a possible involvement of reactive oxygen species (ROS) and development of oxidative stress. To test the proposed hypothesis, human neuroblastoma cells (SH-SY5Y) were exposed to 1800 MHz short-term RF exposure for 10, 30 and 60 minutes. Electric field strength within Gigahertz Transverse Electromagnetic cell (GTEM) was 30 V mand specific absorption rate (SAR) was calculated to be 1.6 W kg. Cellular viability was measured by MTT assay and level of ROS was determined by fluorescent probe 2',7'-dichlorofluorescin diacetate. Concentrations of malondialdehyde and protein carbonyls were used to assess lipid and protein oxidative damage and antioxidant activity was evaluated by measuring concentrations of total glutathione (GSH). After radiation exposure, viability of irradiated cells remained within normal physiological values. Significantly higher ROS level was observed for every radiation exposure time. After 60 min of exposure, the applied radiation caused significant lipid and protein damage. The highest GSH concentration was detected after 10 minute-exposure. The results of our study showed enhanced susceptibility of SH-SY5Y cells for development of oxidative stress even after short-term RF exposure.
PMID: Anat Histol Embryol. 2018 Jun ;47(3):222-230. Epub 2018 Mar 5. PMID: 29504145 Abstract Title: Effect of a 1800 MHz electromagnetic field emitted during embryogenesis on chick development and hatchability. Abstract: The level of artificial electromagnetic field (EMF) has steadily increased with the development of human civilization. The developing chicken embryo has been considered a good model to study the effects of EMF on living organisms. The aim of the study was to determine the effect of a 1800 MHz electromagnetic field during embryogenesis on the frequency of chick embryo malformations, morphometric parameters of the heart and liver and concentration of corticosterone in blood plasma, lipid and glycogen content in the liver of newly hatched chicks. A 1800 MHz EMF was found to shorten the duration of embryogenesis (earlier pipping and hatching of chicks) while having no effect on the quantity and quality of chicks and on increasing the incidence of embryo malformations. Exposure of chick embryos to EMF caused decreases in relative heart weight and right ventricle wall thickness. The pipping and hatching of chicks can be accelerated by stressful impact of EMF, which is confirmed by a significant increase in plasma corticosterone concentrations and decrease in fat and glycogen in the liver of chicks exposed during embryogenesis on the electromagnetic field with a frequency of1800 MHz.
PMID: Electromagn Biol Med. 2015 Mar ;34(1):85-92. Epub 2014 Mar 25. PMID: 24665905 Abstract Title: Oxidative changes and apoptosis induced by 1800-MHz electromagnetic radiation in NIH/3T3 cells. Abstract: To investigate the potential adverse effects of mobile phone radiation, we studied reactive oxygen species (ROS), DNA damage and apoptosis in mouse embryonic fibroblasts (NIH/3T3) after intermittent exposure (5min on/10min off, for various durations from 0.5 to 8h) to an 1800-MHz GSM-talk mode electromagnetic radiation (EMR) at an average specific absorption rate of 2W/kg. A 2',7'-dichlorofluorescin diacetate fluorescence probe was used to detect intracellular ROS levels, immunofluorescence was used to detect H2AX foci as a marker for DNA damage, and flow cytometry was used to measure apoptosis. Our results showed a significant increase in intracellular ROS levels after EMR exposure and it reached the highest level at an exposure time of 1h (p
What does not, or at least should not happen, is that an agent of the government, charged with the task of safeguarding the welfare of children, would completely fabricate contact with a family in order to mask non-compliance with the agencys policy. Providing false testimony of any kind is an unfathomable violation of the trust that the people in the State of Iowa place in their public servants and cast a dark and permanent shadow upon all of us. Judge Adam Sauer
Commentary by Terri
Health Impact News
An Iowa judge recently reprimanded the Department of Human Services (DHS) after a social worker was found to have repeatedly lied...
PMID: J Biosci. 2018 Jun ;43(2):263-276. PMID: 29872015 Abstract Title: Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats. Abstract: Electromagnetic radiation (EMR) can induce or modulate several neurobehavioral disorders. Duration and frequency of exposure of EMR is critical to develop cognitive disorders. Even though EMR-2450 is widely used, its effects on cognition in relation to mitochondrial function and apoptosis would provide better understanding of its pathophysiological effects. Therefore, a comparative study of different frequencies of EMR exposure would give valuable information on effects of discrete frequencies of EMR on cognition. Male rats were exposed to EMR (900, 1800 and 2450 MHz) every day for 1 h for 28 consecutive days. The cognitive behavior in terms of novel arm entries in Y-maze paradigm was evaluated every week after 1 h to last EMR exposure. Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits. EMR- 2450 MHz caused loss of mitochondrial function and integrity, an increase in amyloid beta expression. There was release of cytochrome-c and activation of apoptotic factors such as caspase-9 and -3 in the hippocampus. Further, there was decrease in levels of acetylcholine, and increase in activity of acetyl cholinesterase, indicating impairment of cholinergic system. Therefore, exposure of EMR-2450 in rats caused cognitive deficit with related pathophysiological changes in mitochondrial and cholinergic function, and amyloidogenesis.
PMID: Reprod Health. 2015 Aug 4 ;12:65. Epub 2015 Aug 4. PMID: 26239320 Abstract Title: Electromagnetic radiation at 900 MHz induces sperm apoptosis through bcl-2, bax and caspase-3 signaling pathways in rats. Abstract: BACKGROUND: The decreased reproductive capacity of men is an important factor contributing to infertility. Accumulating evidence has shown that Electromagnetic radiation potentially has negative effects on human health. However, whether radio frequency electromagnetic radiation (RF-EMR) affects the human reproductive system still requires further investigation. Therefore, The present study investigates whether RF-EMR at a frequency of 900 MHz can trigger sperm cell apoptosis and affect semen morphology, concentration, and microstructure.METHODS: Twenty four rats were exposed to 900 MHz electromagnetic radiation with a special absorption rate of 0.660.01 W/kg for 2 h/d. After 50d, the sperm count, morphology, apoptosis, reactive oxygen species (ROS), and total antioxidant capacity (TAC), representing the sum of enzymatic and nonenzymatic antioxidants, were investigated. Western blotting and reverse transcriptase PCR were used to determine the expression levels of apoptosis-related proteins and genes, including bcl-2, bax, cytochrome c, and capase-3.RESULTS: In the present study, the percentage of apoptotic sperm cells in the exposure group was significantly increased by 91.42% compared with the control group. Moreover, the ROS concentration in exposure group was increased by 46.21%, while the TAC was decreased by 28.01%. Radiation also dramatically decreased the protein and mRNA expression of bcl-2 and increased that of bax, cytochrome c, and capase-3.CONCLUSION: RF-EMR increases the ROS level and decreases TAC in rat sperm. Excessive oxidative stress alters the expression levels of apoptosis-related genes and triggers sperm apoptosis through bcl-2, bax, cytochrome c and caspase-3 signaling pathways.
PMID: Toxicol Ind Health. 2007 Aug ;23(7):411-20. PMID: 18536493 Abstract Title: 900 MHz radiofrequency-induced histopathologic changes and oxidative stress in rat endometrium: protection by vitamins E and C. Abstract: There are numerous reports on the effects of electromagnetic radiation (EMR) in various cellular systems. Mechanisms of adverse effects of EMR indicate that reactive oxygen species (ROS) may play a role in the biological effects of this radiation. The aims of this study were to examine 900 MHz mobile phone-induced oxidative stress that promotes production of ROS and to investigate the role of vitamins E and C, which have antioxidant properties, on endometrial tissue against possible 900 MHz mobile phone-induced endometrial impairment in rats. The animals were randomly grouped (eight each) as follows: 1) Control group (without stress and EMR, Group I), 2) sham-operated rats stayed without exposure to EMR (exposure device off, Group II), 3) rats exposed to 900 MHz EMR (EMR group, Group III) and 4) a 900 MHz EMR exposed + vitamin-treated group (EMR + Vit group, Group IV). A 900 MHz EMR was applied to EMR and EMR + Vit group 30 min/day, for 30 days using an experimental exposure device. Endometrial levels of nitric oxide (NO, an oxidant product) and malondialdehyde (MDA, an index of lipid peroxidation), increased in EMR exposed rats while the combined vitamins E and C caused a significant reduction in the levels of NO and MDA. Likewise, endometrial superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities decreased in EMR exposed animals while vitamins E and C caused a significant increase in the activities of these antioxidant enzymes. In the EMR group histopathologic changes in endometrium, diffuse and severe apoptosis was present in the endometrial surface epithelial and glandular cells and the stromal cells. Diffuse eosinophilic leucocyte and lymphocyte infiltration were observed in the endometrial stroma whereas the combination of vitamins E and C caused a significant decrease in these effects of EMR. It is concluded that oxidative endometrial damage plays an important role in the 900 MHz mobile phone-induced endometrial impairment and the modulation of oxidative stress with vitamins E and C reduces the 900 MHz mobile phone-induced endometrial damage both at biochemical and histological levels.
PMID: J Androl. 2012 May-Jun;33(3):350-6. Epub 2011 Jul 28. PMID: 21799142 Abstract Title: Effects of the exposure to mobile phones on male reproduction: a review of the literature. Abstract: The use of mobile phones is now widespread. A great debate exists about the possible damage that the radiofrequency electromagnetic radiation (RF-EMR) emitted by mobile phones exerts on different organs and apparatuses. The aim of this article was to review the existing literature exploring the effects of RF-EMR on the male reproductive function in experimental animals and humans. Studies have been conducted in rats, mice, and rabbits using a similar design based upon mobile phone RF exposure for variable lengths of time. Together, the results of these studies have shown that RF-EMR decreases sperm count and motility and increases oxidative stress. In humans, 2 different experimental approaches have been followed: one has explored the effects of RF-EMR directly on spermatozoa and the other has evaluated the sperm parameters in men using or not using mobile phones. The results showed that human spermatozoa exposed to RF-EMR have decreased motility, morphometric abnormalities, and increased oxidative stress, whereas men using mobile phones have decreased sperm concentration, decreased motility (particularly rapid progressive motility), normal morphology, and decreased viability. These abnormalities seem to be directly related to the duration of mobile phone use.
What does not, or at least should not happen, is that an agent of the government, charged with the task of safeguarding the welfare of children, would completely fabricate contact with a family in order to mask non-compliance with the agencys policy. Providing false testimony of any kind is an unfathomable violation of the trust that the people in the State of Iowa place in their public servants and cast a dark and permanent shadow upon all of us. Judge Adam Sauer
Commentary by Terri
Health Impact News
An Iowa judge recently reprimanded the Department of Human Services (DHS) after a social worker was found to have repeatedly lied to...
PMID: J Clin Endocrinol Metab. 2018 Sep 27. Epub 2018 Sep 27. PMID: 30265356 Abstract Title: Role of Selenium Intake for Risk and Development of Hyperthyroidism. Abstract: Purpose: To investigate the importance of dietary Se supply for hyperthyroidism.Methods: We performed a more in-depth analysis of a large cross-sectional study of 6152 participants from two counties within the Shaanxi Province, China, which are characterized by different habitual Se intakes, and investigated the effects of different dietary Se supply (0.02, 0.18, 0.6 or 2.0 ppm Se) on disease development in a mouse model of GD.Results: The cross-sectional study revealed a comparable prevalence of hyperthyroidism irrespective of Se intake in both counties. However, an unexpected sex-specific difference was noted, and Se deficiency may constitute risk factor for hyperthyroidism particularly in males. In the mouse model, pathological thyroid morphology was affected, and higher Se intakes exerted some protecting effects on the pathological distortion. Circulating thyroid hormone levels, malondialdehyde concentrations, total antioxidant capacity or the titer of GD-causing TSH receptor autoantibodies (TRAb) were not affected by Se. Expression analysis of transcripts in spleen indicated regulatory effects on genes implicated in the immune response, erythropoiesis and oxygen status. However, the humoral immune response including the ratio of CD4/CD8 or Th1/Th2 cells, and the concentration of Treg cells were similar between the experimental groups, despite their varying Se intakes.Conclusions: Our data highlight a novel sexual dimorphism for the interaction of Se and thyroid disease risk in humans, and indicate local protective effects of Se on thyroid gland integrity which appear not to be reflected in the circulating biomarkers tested.
PMID: Biometals. 2018 Oct 4. Epub 2018 Oct 4. PMID: 30288658 Abstract Title: Selenium-Rich Yeast protects against aluminum-induced peroxidation of lipide and inflammation in mice liver. Abstract: To investigate the effect of Selenium Rich Yeast (SeY) on hepatotoxicity of Aluminium (Al), SeY (0.1 mg/kg) was orally administrated to aluminium-exposed mice (10 mg/kg) for 28 days. The risk of oxidative stress was assessed by detecting the total antioxidant capacity (T-AOC), catalase activity, HOcontent, and mRNA levels of the Keap1/Nrf-2/HO-1 pathway. Inflammatory reactions were assessed by detecting the mRNA levels of inflammatory biomarkers. Our results showed that SeY protected against the liver histological changes induce by Al. The body weight gain of mice treated with SeY+ Al restore to normal compare with mice exposed to Al alone. Al treatment significantly decreased the activities of antioxidant enzymes, reduced T-AOC levels, and up-regulated the mRNA level of Nrf2 and HO-1, thereby ultimately leading to peroxidation. SeY shown a significant protective effectagainst oxidative stress caused by Al. In addition, Al exposure induced inflammatory responses in rat liver by promoting the release of inflammatory cytokines (TNF-a, NF-kB, TNF-R1, IL-1, IL-6, and COX-2). SeY protected against changes in liver by regulating the mRNA expression levels of inflammatory factors. These results suggested that Se protected the liver from the Al-induced hepatotoxicity by regulating the mRNA level of Keap1/Nrf2/HO-1, and inhibited inflammatory responses by down-regulating the expression level of inflammatory cytokine.
By Sara Tipton
The end of the summer garden is always bittersweet for me. I miss my daily fresh cut lettuce but I also love the falling leaves and bright reds and oranges of autumn. Luckily, those fallen leaves are more than just pleasing to look at. In this helpful guide, well walk you through a few easy ways to use your fallen autumn leaves as zero waste and cheaper options around your place.
One of the best sustainable and organic ways to help prepare your garden is to add a mulch, and the beautiful fallen leaves of autumn are a great way to this. According to Ready Nutrition, in the gardening community, leaves are huge. When they are composted they become known as black gold, a nutrient-rich material that can be used in a multitude of ways in the garden.
The life cycle of a leaf begins when a tree makes its leaves in the spring. The tree concentrates all of its energy and nutrients into making the leaves because the more leaves there are, the more photosynthesis can occur. When the leaves drop in autumn, they create a ground cover for the trees to conserve moisture. As the leaves decompose, they provide the tree with nutrients and resupply the depleted soil with microbes. The roots of trees can then absorb the nutrients and minerals via the soil in order to create even more leaves the next spring. Its a unique life cycle that can be taken advantage of.
By Elizabeth Millard
Robust gut health isnt just about digestionalthough it plays a major role. The way your digestion system functions has been linked to an array of physiological processes, including hormone regulation, toxin elimination, defense against bacteria and viruses, cell regeneration, and more.
Theres so much control happening throughout your GI tract, that its been called the second brain, and when disease, stress, pollutants, or poor nutrition negatively affects that brain, it can have a profound impact on how you operate. Thats why a substance like CBD oilwhich has effects throughout the digestive systemshows such promise for gut health.
There are cannabinoid receptors in the GI tract that are there to help maintain homeostasis within the body, says Michelle Weiner, DO, MPH, of the Spine and Wellness Centers of America. When your gut is out of whack, it can have a ripple effect throughout every system, affecting everything from your immune response to your emotional health. CBD can help get you back on track by addressing and correcting imbalances in the gut.
When it comes to the mechanisms...
PMID: Int J Radiat Biol. 2012 Nov ;88(11):799-805. Epub 2012 Aug 8. PMID: 22788526 Abstract Title: Oxidative stress induced by 1.8 GHz radio frequency electromagnetic radiation and effects of garlic extract in rats. Abstract: PURPOSE: We aimed to study the oxidative damage induced by radiofrequency electromagnetic radiation (RF-EMR) emitted by mobile telephones and the protective effect of garlic extract used as an anti-oxidant against this damage.MATERIALS AND METHODS: A total of 66 albino Wistar rats were divided into three groups. The first group of rats was given 1.8 GHz, 0.4 W/kg specific absorption rate (SAR) for 1 h a day for three weeks. The second group was given 500 mg/kg garlic extract in addition to RF-EMR. The third group of rats was used as the control group. At the end of the study, blood and brain tissue samples were collected from the rats.RESULTS: After the RF-EMR exposed, the advanced oxidation protein product (AOPP) levels of brain tissue increased compared with the control group (p0.05). We did not detect any PON levels in the brain tissue.CONCLUSIONS: The exposure of RF-EMR similar to 1.8 GHz Global system for mobile communication (GSM) leads to protein oxidation in brain tissue and an increase in serum NO. We observed that garlic administration reduced protein oxidation in brain tissue and that it did not have any effects on serum NO levels.
PMID: Mol Vis. 2008 May 19 ;14:964-9. Epub 2008 May 19. PMID: 18509546 Abstract Title: Electromagnetic noise inhibits radiofrequency radiation-induced DNA damage and reactive oxygen species increase in human lens epithelial cells. Abstract: PURPOSE: The goal of this study was to investigate whether superposing of electromagnetic noise could block or attenuate DNA damage and intracellular reactive oxygen species (ROS) increase of cultured human lens epithelial cells (HLECs) induced by acute exposure to 1.8 GHz radiofrequency field (RF) of the Global System for Mobile Communications (GSM).METHODS: An sXc-1800 RF exposure system was used to produce a GSM signal at 1.8 GHz (217 Hz amplitude-modulated) with the specific absorption rate (SAR) of 1, 2, 3, and 4 W/kg. After 2 h of intermittent exposure, the ROS level was assessed by the fluorescent probe, 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA). DNA damage to HLECs was examined by alkaline comet assay and the phosphorylated form of histone variant H2AX (gammaH2AX) foci formation assay.RESULTS: After exposure to 1.8 GHz RF for 2 h, HLECs exhibited significant intracellular ROS increase in the 2, 3, and 4 W/kg groups. RF radiation at the SAR of 3 W/kg and 4 W/kg could induce significant DNA damage, examined by alkaline comet assay, which was used to detect mainly single strand breaks (SSBs), while no statistical difference in double strand breaks (DSBs), evaluated by gammaH2AX foci, was found between RF exposure (SAR: 3 and 4 W/kg) and sham exposure groups. When RF was superposed with 2 muT electromagnetic noise could block RF-induced ROS increase and DNA damage.CONCLUSIONS: DNA damage induced by 1.8 GHz radiofrequency field for 2 h, which was mainly SSBs, may be associated with the increased ROS production. Electromagnetic noise could block RF-induced ROS formation and DNA damage.
PMID: Toxicol Lett. 2013 Mar 27 ;218(1):2-9. Epub 2013 Jan 18. PMID: 23333639 Abstract Title: Exposure to 1800 MHz radiofrequency electromagnetic radiation induces oxidative DNA base damage in a mouse spermatocyte-derived cell line. Abstract: Whether exposure to radiofrequency electromagnetic radiation (RF-EMR) emitted from mobile phones can induce DNA damage in male germ cells remains unclear. In this study, we conducted a 24h intermittent exposure (5 min on and 10 min off) of a mouse spermatocyte-derived GC-2 cell line to 1800 MHz Global System for Mobile Communication (GSM) signals in GSM-Talk mode at specific absorption rates (SAR) of 1 W/kg, 2 W/kg or 4 W/kg. Subsequently, through the use of formamidopyrimidine DNA glycosylase (FPG) in a modified comet assay, we determined that the extent of DNA migration was significantly increased at a SAR of 4 W/kg. Flow cytometry analysis demonstrated that levels of the DNA adduct 8-oxoguanine (8-oxoG) were also increased at a SAR of 4 W/kg. These increases were concomitant with similar increases in the generation of reactive oxygen species (ROS); these phenomena were mitigated by co-treatment with the antioxidant-tocopherol. However, no detectable DNA strand breakage was observed by the alkaline comet assay. Taking together, these findings may imply the novel possibility that RF-EMR with insufficient energy for the direct induction of DNA strand breaks may produce genotoxicity through oxidative DNA base damage in male germ cells.
John C. Dvorak from the No Agenda Show podcast wrote for PC Magazine for THIRTY YEARS. However, while he wrote extensively for the magazine, in August of this year he wrote a less than PC (pun intended!) article about the dangers of 5G (read it here) entitled, The Problem With 5G. Unhappy with what he wrote, 
A few months ago I was surprised to receive a request from an obscure journal of consciousness studies to review a paper. I was surprised because, although it was not immediately obvious from the title, the paper contained the first reports of the primary outcome measure of the massive and notorious STAR-D study, 14 years after the study was finished.
What in the world were the main findings of the worlds largest ever antidepressant trial doing being presented now in a little known journal? The answer may lie in the fact that they show how miserably poor the results of standard medical treatment for depression really are!
With 4041 participants, the STAR-D study is by far the largest and most expensive study of antidepressants ever conducted. The intention of the study was to see how antidepressant treatment combined with high quality care performed in usual clinical conditions. It did not involve a placebo or any sort of control. All treatment was provided free for the duration of the study to maximise engagement.
The paper I was asked to review, which is now published in Psychology of Consciousness: Theory, Research and Practice, is written by a group led by Irving Kirsch and based on the original data obtained through the NIMH.1 Shannon Peters describes its findings in detail.
Kirschs group point out that the paper that describes the design of the STAR-D trial clearly identifies the Hamilton Rating Scale for Depression (HRSD) as the primary outcome.2 This makes sense since the HRSD is one of the most commonly used rating scales in trials of treatment of depression, especially trials of antidepressants. As the STAR-D authors note in the study protocol the HAM-D17 (HRSD), the primary outcome, allows comparison to the vast RCT literature (cited in (1)).
Yet the outcome that was presented in almost all the study papers was the QIDS (Quick Inventory of Depressive Symptomatology), a measure made up especially for the STAR-D study, with no prior or subsequent credentials. In fact, as the authors of the present paper point out, this measure was devised not as an outcome measure, but as a way of tracking symptoms during th...
So much of what we are is based on what we eat. Plain and simple. Eat good, whole foods and youll nourish your body. Put junk in it and youll feel it. And with prolonged bad eating habits, there might even be serious consequences. RELATED STORY: The filthiest food you can eat, yet most think 
The post The Healing Power of Food Summit: Online, free October 13- 21 appeared first on Health Nut News.
A recent report in the Lok Sabha secretariat revealed that groundwater in a number of districts in Delhi contains a high level of fluoride, arsenic, and nitrate affecting the health of Delhiites. With one-third of groundwater in Delhi and the NCR containing an excessive concentration of fluoride, an increasing number of people are getting afflicted with arthritis and osteoarthritis, a rheumatic condition that affects joints and worsens with growing age.
In India, the most common cause of fluorosis is high-fluoride well water derived from borewells dug deep into the earth. High concentration of fluoride in groundwater beyond the permissible limit of 1.5 mg/L is a major health problem in India. Nearly 90 per cent of the rural population of the country uses groundwater for drinking and domestic purposes and due to excess fluoride in groundwater, a huge chunk of the rural population is threatened with health hazards triggered by fluorosis, said Dr Raju Vaishya, President, Indian Cartilage Society and Arthritis Care.
According to medical studies, skeletal fluorosis occurs when the fluoride concentration in water exceeds one part per million (ppm). Radiologically detectable skeletal fluorosis occurs in populations with typical exposures of 8 mg/day.
Fluoride can cause chronic joint pain prior to causing x-ray-detectable fluorosis. Thus, for some individuals, the doses that can cause arthritic pain will be less than the 6 to 8 mg/day that causes radiologically detectable bone changes. While the advanced stages produce extreme, visibly crippling, effects on the skeleton, the earlier stages are less obvious, and extremely difficult to diagnose. There are three forms of fluoride poisoning or fluorosis. These are dental fluorosis, non-skeletal fluorosis, and skeletal fluorosis. Among individuals with skeletal fluorosis, the fluoride-induced changes to the bone, joints, and spine can cause widespread joint pain, arthritis and osteoarthritis, said Vaishya.
A common finding among researchers investigating fluorosis is that the early stages are marked by symptoms (stiff and painful joints) which are frequently difficult to differentiate from various types of arthritis.
Dear Retraction Watch readers: Have you seen our database of retractions? While were still putting finishing touches on it before an official launch, with more than 18,000 retractions, its already the most comprehensive collection of retractions anywhere. We have learned a great deal as weve gathered those retractions, which we look forward to sharing quite soon, Continue reading Retraction Watch readers, we need your help to be able to continue our work
Youve heard of Monopoly, right? The fun little board game with fake money, little plastic houses, and get out of jail free cards? Its a great way to pass the time. That is, depending on who youre playing with. But when it comes to real-life properties, business, and products, however, a monopoly becomes a whole 
The post Monsanto and Bayer are moving to create a monopoly on marijuana appeared first on Health Nut News.
By Louis Conte Robert F. Kennedy Jr., Chairman of Childrens Health Defense (CHD) and Rolf Hazlehurst, the father of a vaccine-injured child have petitioned Michael Horowitz, the Inspector General of the Department of Justice (DOJ) to investigate the conduct of two DOJ attorneys, Vincent Matanoski and Lynn Ricciardella. The two attorneys represented the Secretary of 
The post Misconduct, mitochondria and the Omnibus Autism Proceedings appeared first on Health Nut News.
In this interview, J.B. Handley, founder of Generation Rescue, discusses autism and what he believes can be done to help turn this tragic trend around. This is also the topic of his book, How to End the Autism Epidemic. RELATED STORY: ACTION ALERT! Ask for investigation of Fraud and Obstruction of Justice in the Omnibus 
According to the journal JPRAS Open, a Nebraska woman was infected with salmonella in her breast implant after coming down with travelers diarrhea during her vacation to Mexico. The 34-year-old patient, who was not named in the JPRAS Open case report, was otherwise healthy before vacationing in Cancun and is believed to be the first documented case of 
The post Fox: US woman develops salmonella in breast implant after trip to Cancun appeared first on Health Nut News.
Photo Credit: Flickr
By Dr. Mercola
Flax (Linum usitatissimum1) is among the most ancient of superfoods, with a history of use spanning over 10,000 years. Remains of flaxseed have been found in Stone Age dwellings in Switzerland, and in Egypt, where the ancient Egyptians used it in the manufacture of linen. Flax reached the U.S. in the 1800s with the arrival of European settlers.
Flax can be grown for a nutritional seed harvest, and its fiber is used in the making of linen. The plant grows to about 3 feet tall and has narrow, pale green leaves and small blue flowers.
Once the flower drops off, a seedpod forms in its place. Each seedpod contains anywhere from four to 10 seeds. According to Mother Earth Living,2 a small 4-foot-square plot of flax can provide enough seeds for a batch of bread and enough fiber to fashion a small basket.
Thanks to its adaptability, flax can be grown in most parts of the U.S. Ideally, select a plot that gets plenty of sun with fertile, well-draining soil. Flax grows best in cooler weather, so early spring, once the risk of frost has passed, is an ideal time to start your planting.
Youll need about 1 tablespoon of flaxseed per 10 square feet. The seeds are small, so the easiest way to sow them is to mix them with a small amount of flour, which helps separate them. Scatter the seeds across the surface of the plot, then use a rake to gently mix them into the top half-inch of the soil.
Water gently and keep the soil moist but not soaked until the seeds have germinated, which takes about 10 days. Once theyve germinated, the plants tend to develop a robust root system and require less frequent watering. The plant matures to a height of about 3 feet. Adding a nitrogen-rich amendment to your soil can boost seed yield; otherwise, fertilizer is generally not needed.
Aside from L. usitatissimum, several other species of flax are also available. For example, perennial flax (L. perenne) grows to a height of just 1 to 2 feet and is hardy in zones 5 to 9. The cultivar Alba produces white flowers instead of blue. Golden flax (L. flavum), which is native to Europe, grows to be about 1.5 feet tall and has yellow flowers. It fares best in zone 5.
While flax provides you with more than one harvest opportunity, you will need to decide whether youre going to harvest seeds or the fiber, as the highest quality fiber is obtained before the seeds form. Alternatively, you can settle for a coarser fiber, which will allow you to h...
By Dr. Mercola
Growing your own fruits and vegetables is one of the best ways to ensure access to fresh, chemical-free food. An annual National Gardening Survey1 finds the proportion of older gardeners is holding steady while younger individuals who enjoy gardening is reaching an all-time high. Container and landscape gardening are also setting new records.
Gardening provides a sensory experience and may help improve your mood.2 A study from the Netherlands suggests gardening may fight stress better than other leisure activities. A study from Norway found those who suffered from depression or bipolar disorder experienced measurable improvements after spending three months gardening six hours a week.3
There are an amazing number and variety of plants you may include in your backyard or container garden. Some plants serve several purposes, such as edible leaves and seeds and beautiful flowers. The amaranth is a wonderful example of a plant you might consider for your flower garden or vegetable garden, as it is an excellent option for either.
The Incas used amaranth grain as a prized health food, but you might find the flowers have great ornamental value in a sunny garden bed. Grain amaranth species have been important for several thousand years, and the largest known acreage was grown during the Aztec civilization in the 1400s.4
However, when Cortes and his army entered the Aztec capital they found amaranth was more than mere food. It was used in ceremonial and religious events. Cortes was bent on eliminating pagan rituals, and so ordered fields of amaranth to be burned and strict punishment enforced, including death, for those possessing the grain.5
During the past two centuries, grain amaranth has been grown throughout Mexico, Central America, India, China and Eastern Africa. There is a movement to revive amaranth as a staple crop in Mexico as it has high nutritional value and is able to withstand high temperatures. Although not actually a grain, its nutritional composition is so similar it's often included with...
PMID: Clinics (Sao Paulo). 2009 ;64(6):561-5. PMID: 19578660 Abstract Title: Radio frequency electromagnetic radiation (RF-EMR) from GSM (0.9/1.8GHz) mobile phones induces oxidative stress and reduces sperm motility in rats. Abstract: INTRODUCTION: Mobile phones have become indispensable in the daily lives of men and women around the globe. As cell phone use has become more widespread, concerns have mounted regarding the potentially harmful effects of RF-EMR from these devices.OBJECTIVE: The present study was designed to evaluate the effects of RF-EMR from mobile phones on free radical metabolism and sperm quality.MATERIALS AND METHODS: Male albino Wistar rats (10-12 weeks old) were exposed to RF-EMR from an active GSM (0.9/1.8 GHz) mobile phone for 1 hour continuously per day for 28 days. Controls were exposed to a mobile phone without a battery for the same period. The phone was kept in a cage with a wooden bottom in order to address concerns that the effects of exposure to the phone could be due to heat emitted by the phone rather than to RF-EMR alone. Animals were sacrificed 24 hours after the last exposure and tissues of interest were harvested.RESULTS: One hour of exposure to the phone did not significantly change facial temperature in either group of rats. No significant difference was observed in total sperm count between controls and RF-EMR exposed groups. However, rats exposed to RF-EMR exhibited a significantly reduced percentage of motile sperm. Moreover, RF-EMR exposure resulted in a significant increase in lipid peroxidation and low GSH content in the testis and epididymis.CONCLUSION: Given the results of the present study, we speculate that RF-EMR from mobile phones negatively affects semen quality and may impair male fertility.
PMID: PLoS One. 2009 Jul 31 ;4(7):e6446. Epub 2009 Jul 31. PMID: 19649291 Abstract Title: Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro. Abstract: BACKGROUND: In recent times there has been some controversy over the impact of electromagnetic radiation on human health. The significance of mobile phone radiation on male reproduction is a key element of this debate since several studies have suggested a relationship between mobile phone use and semen quality. The potential mechanisms involved have not been established, however, human spermatozoa are known to be particularly vulnerable to oxidative stress by virtue of the abundant availability of substrates for free radical attack and the lack of cytoplasmic space to accommodate antioxidant enzymes. Moreover, the induction of oxidative stress in these cells not only perturbs their capacity for fertilization but also contributes to sperm DNA damage. The latter has, in turn, been linked with poor fertility, an increased incidence of miscarriage and morbidity in the offspring, including childhood cancer. In light of these associations, we have analyzed the influence of RF-EMR on the cell biology of human spermatozoa in vitro.PRINCIPAL FINDINGS: Purified human spermatozoa were exposed to radio-frequency electromagnetic radiation (RF-EMR) tuned to 1.8 GHz and covering a range of specific absorption rates (SAR) from 0.4 W/kg to 27.5 W/kg. In step with increasing SAR, motility and vitality were significantly reduced after RF-EMR exposure, while the mitochondrial generation of reactive oxygen species and DNA fragmentation were significantly elevated (P
PMID: Front Public Health. 2018 ;6:270. Epub 2018 Sep 21. PMID: 30298125 Abstract Title: Probing the Origins of 1,800 MHz Radio Frequency Electromagnetic Radiation Induced Damage in Mouse Immortalized Germ Cells and Spermatozoa. Abstract: As the use of mobile phone devices is now highly prevalent, many studies have sought to evaluate the effects of the radiofrequency-electromagnetic radiation (RF-EMR) on both human health and biology. While several such studies have shown RF-EMR is capable of inducing cellular stress, the physicobiological origin of this stress remains largely unresolved. To explore the effect of RF-EMR on the male reproductive system, we exposed cultured mouse spermatogonial GC1 and spermatocyte GC2 cell lines, as well as cauda epididymal spermatozoa to a waveguide generating continuous wave RF-EMR (1.8 GHz, 0.15 and 1.5 W/kg). This study demonstrated that a 4 h exposure is capable of inducing the generation of mitochondrial reactive oxygen species (ROS) in populations of GC1 (7 vs. 18%;
PMID: Front Behav Neurosci. 2018 ;12:170. Epub 2018 Aug 6. PMID: 30127728 Abstract Title: Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring. Abstract: Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administration on valproic acid (VPA)-induced autistic-like behavioral deficits, and the associated underlying mechanism in adolescent mice offspring. Pregnant ICR mice were randomly divided into five groups (= 6). One group was injected with saline (NAV group) and provided hydrogen-free water. The other four groups were injected with VPA (600 mg/kg, intraperitoneally, i.p.) on pregnant day (PND) 12.5. One group was provided with hydrogen-free water (VEH group) and the other three groups were provided HRW at different segments, postnatal day 1 (PND 1) to PND 21 (PHV group), PND 13 to PND 21 (PVS group) or from PND 13 to postnatal day 42 (PVL group). Behavioral tests, including open field, novelty suppressed feeding (NSF), hot plate, social interaction (SI) and contextual fear memory tests were conducted between postnatal day 35-42. We found that HRW administration significantly reversed the autistic-like behaviors induced by maternal VPA exposure in the adolescent offspring of both male and female adolescent offspring. Furthermore, HRW administration significantly reversed the alternation of serum levels of interleukin 6 (IL-6) and tumor necrosis factor- (TNF-), but without any effects on the BDNF levels in maternal VPA-exposed mice offspring. These data suggest the need for additional research on HRW as a potential preventive strategy for autism and related disorders.: Maternal VPA injection induces autistic-like behavioral deficits in adolescent mice offspring. HRW administration ameliorates autistic-like behavioral deficits. HRW administration reverses the alternation of serum levels of IL-6 and TNF- induced by VPA.
PMID: J Radiat Res. 2018 Sep 27. Epub 2018 Sep 27. PMID: 30260398 Abstract Title: The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats. Abstract: This study aimed to determine the healing effect of hydrogen-rich water (HRW) on radiotherapy-induced skin injury. Rats were irradiated with a 6 MeV electron beam from a Varian linear accelerator. After skin wound formation, rats were individually administrated with distilled water, HRW (1.0 ppm) or HRW (2.0 ppm). We measured the healing time and observed the healing rate of the wounded surface. After irradiation, the malondialdehyde (MDA) content and the superoxide dismutase (SOD) activity in the wounded tissues were evaluated, as determined using an MDA and SOD assay kit. Interleukin-6 (IL-6) and epidermal growth factor (EGF) levels were assessed by enzyme-linked immunosorbent assay (ELISA). Models of skin damage were successfully established using a 44 Gy electronic beam. The healing time was shortened in the two HRW-treated groups (P
(ANTIMEDIA) In an age of technology and constant immersion in the digital sphere, a new initiative in Shetland, Scotland is encouraging individuals suffering from chronic illness to spend more time in nature.
The Royal Society for the Protection of Birds (RSPB) has teamed up with the National Health Service in Shetland to promote Nature Prescriptions. Doctors in the region can now officially prescribe nature to their patients.
According to a statement from the RSPB:
From reducing cardiovascular disease, hypertension, stress levels, rates of aggression, obesity. It can be used when treating Type II diabetes or depression or when recovering from operations, and it has been proven over and over again to provide relief from anxiety. Plus its free and easily accessible to all. It makes complete sense to work with the medical profession to connect people with nature.
PMID: J Dent. 2017 Mar ;58:34-39. Epub 2017 Jan 10. PMID: 28087297 Abstract Title: Inhibition of streptococcal biofilm by hydrogen water. Abstract: OBJECTIVES: The accumulation of oral bacterial biofilm is the main etiological factor of oral diseases. Recently, electrolyzed hydrogen-rich water (H-water) has been shown to act as an effective antioxidant by reducing oxidative stress. In addition to this general health benefit, H-water has antibacterial activity for disease-associated oral bacteria. However, little is known about the effect of H-water on oral bacterial biofilm. The objective of this study was to confirm the effect of H-water on streptococcal biofilm formation.METHODS: In vitro streptococcal biofilm was quantified using crystal violet staining after culture on a polystyrene plate. The effect of H-water on the expression of genes involved in insoluble glucan synthesis and glucan binding, which are critical steps for oral biofilm formation, was evaluated in MS. In addition, we compared the number of salivary streptococci after oral rinse with H-water and that with control tap water. Salivary streptococci were quantified by counting viable colonies on Mitis Salivarius agar-bacitracin.RESULTS: Our data showed that H-water caused a significant decrease in in vitro streptococcal biofilm formation. The expression level of the mRNA of glucosyltransferases (gtfB, gtfc, and gtfI) and glucan-binding proteins (gbpC, dblB) were decreased remarkably in MS after H-water exposure for 60s. Furthermore, oral rinse with H-water for 1 week led to significantly fewer salivary streptococci than did that with control tap water.CONCLUSIONS: Our data suggest that oral rinse with H-water would be helpful in treating dental biofilm-dependent diseases with ease and efficiency.
PMID: Environ Microbiol. 2017 02 ;19(2):566-583. Epub 2016 Sep 9. PMID: 27554678 Abstract Title: Hydrogen-rich water regulates effects of ROS balance on morphology, growth and secondary metabolism via glutathione peroxidase in Ganoderma lucidum. Abstract: Ganoderma lucidum is one of the most important medicinal fungi, but the lack of basic study on the fungus has hindered the further development of its value. To investigate the roles of the redox system in G. lucidum, acetic acid (HAc) was applied as a reactive oxygen species (ROS) stress inducer, and hydrogen-rich water (HRW) was used to relieve the ROS stress in this study. Our results demonstrate that the treatment of 5% HRW significantly decreased the ROS content, maintained biomass and polar growth morphology of mycelium, and decreased secondary metabolism under HAc-induced oxidative stress. Furthermore, the roles of HRW were largely dependent on restoring the glutathione system under HAc stress in G. lucidum. To provide further evidence, we used two glutathione peroxidase (GPX)-defective strains, the gpxi strain, the mercaptosuccinic acid (MS, a GPX inhibitor)-treated wide-type (WT) strain, and gpx overexpression strains for further research. The results show that HRW was unable to relieve the HAc-induced ROS overproduction, decreased biomass, mycelium morphology change and increased secondary metabolism biosynthesis in the absence of GPX function. The gpx overexpression strains exhibited resistance to HAc-induced oxidative stress. Thus, we propose that HRW regulates morphology, growth and secondary metabolism via glutathione peroxidase under HAc stress in the fungus G. lucidum. Furthermore, our research also provides a method to study the ROS system in other fungi.
PMID: Biochem Biophys Res Commun. 2008 Oct 24 ;375(3):346-50. Epub 2008 Aug 14. PMID: 18706888 Abstract Title: Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Abstract: Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen's effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of H(2), VC, or pure water (H(2)O), administered for 33 days. VC levels in H(2) and H(2)O groups were
PMID: Jpn J Radiol. 2011 Aug ;29(7):503-12. Epub 2011 Sep 1. PMID: 21882093 Abstract Title: Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. Abstract: PURPOSE: The aim of this study was to assess the mechanism of the protective effect of hydrogen-rich water (HW) against cisplatin (CP)-induced nephrotoxicity in rats using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).MATERIALS AND METHODS: Apparent transverse relaxation time-weighted images (T2 WI) were acquired in 28 rats. The control group (n = 7) had free access to standard water (SW) and no CP injection. The CP group (n = 7) had free access to SW and was given a CP injection on day 0. The CP+HW group (n = 7) had free access to HW and had a CP injection. The HW group (n = 7) had free access to HW and no CP injection. The apparent transverse relaxation rate (R2) was estimated from T2 WI.RESULTS: In the CP+HW group, the R2 value in the medulla normalized by the value of the day 0 was significantly greater than that in the CP group on days 4 and 7. The creatinine and blood urea nitrogen levels in the CP group were significantly higher than those in the control, CP+HW, and HW groups.CONCLUSION: BOLD MRI may be useful for demonstrating the change in R2 in CP-induced nephrotoxicity in rats. The changes in the CP+HW group were suspected to be due to a reduction of cytotoxic oxygen radicals.
n/a PMID: Br J Radiol. 2010 Jun ;83(990):509-14. PMID: 20505032 Abstract Title: Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Abstract: Our aim was to assess the protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT (DCE-CT). DCE-CT studies were performed in 30 rats (8 weeks old) on days 0, 2, 4 and 7 using multidetector row CT. The rats were divided into three groups: a control group (n = 6) with free access to standard water and without cisplatin injection, a non-treatment group (n = 12) with free access to standard water and injected with cisplatin (3.6 mg kg(-1) body weight) intraperitoneally on day 0 and a treatment group (n = 12) with free access to hydrogen-rich water starting from 7 days before cisplatin injection. The contrast clearance per unit renal volume (K(1)) was estimated from the DCE-CT data using the Patlak model. The contrast clearance of the entire kidney (K) was obtained by multiplying K(1) by the renal volume. The serum creatinine level was also measured on day 7. The K(1) and K values normalised by those on day 0 in the treatment group were significantly greater than those in the non-treatment group on days 2, 4 and 7. There were no significant differences in the normalised K value between the treatment and control groups on days 2 and 7. The serum creatinine level in the treatment group was significantly lower than that in the non-treatment group and was not significantly different from that in the control group. This study demonstrated that hydrogen-rich water ameliorates renal dysfunction due to cisplatin-induced nephrotoxicity in rats.
PMID: Magn Reson Med Sci. 2011 ;10(3):169-76. PMID: 21959999 Abstract Title: Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Abstract: PURPOSE: We assessed intrarenal oxygenation in gentamicin-induced nephrotoxicity (GIN) and the protective effect of hydrogen-rich water (HW) against GIN using blood oxygenation level-dependent magnetic resonance (MR) imaging.MATERIALS AND METHODS: We acquired T(2)*-weighted images (T(2)*WI) of 21 rats on Days 0, 2, 4, and 7 using a 1.5-tesla MR imaging system. The rats were divided into 3 groups of seven each: control rats had free access to standard water and no gentamicin (GM) injection; rats designated the GM group had free access to standard water and were injected with GM (80 mg/kg/day) subcutaneously for 7 days; and the third group, designated the GM+HW group, had free access to HW and were injected with GM. R(2)* (=1/T(2)*) was estimated from T(2)*WI.RESULTS: R(2)* values in the cortex were significantly decreased on Days 2, 4, and 7 compared with those on Day 0 in the GM group but not significantly changed in the control and GM+HW groups. R(2)* values in the medulla did not change significantly in any group.CONCLUSIONS: Our findings suggested reduced oxygen utility, mainly in the cortex, in gentamicin-induced nephrotoxicity and an ameliorative effect of hydrogen-rich water against GIN.
PMID: J Photochem Photobiol B. 2012 Jan 5 ;106:24-33. Epub 2011 Oct 20. PMID: 22070900 Abstract Title: Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. Abstract: Hydrogen-rich electrolyzed warm water (HW) was prepared at 41C and exhibited dissolved hydrogen (DH) of 1.13 ppm and an oxidation-reduction potential (ORP) of -741 mV in contrast to below 0.01 ppm and+184 mV for regular warm water (RW). Fibroblasts OUMS-36 and keratinocytes HaCaT were used to examine effects of HW against UVA-ray irradiation. Type-I collagen was synthesized 1.85- to 2.03-fold more abundantly by HW application for 3-5 days than RW in OUMS-36 fibroblasts, and localized preferentially around the nuclei as shown by immunostain. HW application significantly prevented cell death and DNA damages such as nuclear condensation and fragmentationin UVA-irradiated HaCaT keratinocytes as estimated by WST-1 and Hoechst 33342 assays. HW significantly suppressed UVA-induced generation of intracellular superoxide anion radicals in both the cell lines according to NBT assay. Wrinkle repression was clinically assessed using a HW-bathing. Six Japanese subjects were enrolled in a trial of HW-bathing (DH, 0.2-0.4 ppm) every day for 3 months. HW-bathing significantly improved wrinkle in four subjects on the back of neck on 90th day as compared to 0 day. Thus, HW may serve as daily skin care to repress UVA-induced skin damages by ROS-scavenging and promotion of type-I collagen synthesis in dermis.
PMID: Hepatology. 2012 Sep ;56(3):912-21. Epub 2012 Jul 17. PMID: 22505328 Abstract Title: Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Abstract: UNLABELLED: Oxidative stress is a strong contributor to the progression from simple fatty liver to nonalcoholic steatohepatitis (NASH). Molecular hydrogen is an effective antioxidant that reduces cytotoxic reactive oxygen species. In this study, we investigated the effects of hydrogen-rich water and the drug pioglitazone on the progression of NASH in mouse models. A methionine-choline-deficient (MCD) diet mouse model was prepared. Mice were divided into three experimental groups and fed for 8 weeks as follows: (1) MCD diet + control water (CW group); (2) MCD diet + hydrogen-rich water (HW group); and (3) MCD diet mixed with pioglitazone (PGZ group). Plasma alanine aminotransferase levels, hepatic expression of tumor necrosis factor-, interleukin-6, fatty acid synthesis-related genes, oxidative stress biomarker 8-hydroxydeoxyguanosine (8-OHdG), and apoptosis marker terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the liver were decreased in the HW and PGZ groups. The HW group showed a smaller decrease in hepatic cholesterol; however, stronger antioxidative effects in serum and lower peroxisome proliferator-activated receptor- expression in the liver were seen in comparison with the PGZ group. We then investigated the effects of hydrogen in the prevention of hepatocarcinogenesis in STAM mice, known as the NASH-related hepatocarcinogenesis model. Eight-week-old male STAM mice were divided into three experimental groups as follows: (1) control water (CW-STAM); (2) hydrogen-rich water (HW-STAM); and (3) pioglitazone (PGZ-STAM). After 8 weeks, hepatic tumors were evaluated. The number of tumors was significantly lower in the HW-STAM and PGZ-STAM groups than in the CW-STAM group. The maximum tumor size was smaller in the HW-STAM group than in the other groups.CONCLUSION: Consumption of hydrogen-rich water may be an effective treatment for NASH by reducing hepatic oxidative stress, apoptosis, inflammation, and hepatocarcinogenesis.
PMID: Chem Biol Interact. 2015 Oct 5 ;240:12-21. Epub 2015 Aug 10. PMID: 26271894 Abstract Title: Hydrogen-rich water attenuates amyloid-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Abstract: Amyloid (A) peptides are identified in cause of neurodegenerative diseases such as Alzheimer's disease (AD). Previous evidence suggests A-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. The accumulation of A-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as AD. Recently, hydrogen-rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities.However, the precise molecular mechanisms whereby HRW prevents neuronal death are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against A-induced cytotoxicity. Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of A-induced cell death. In addition, HRW also stimulated AMP-activated protein kinase (AMPK) in a sirtuin 1 (Sirt1)-dependent pathway, which upregulates forkhead box protein O3a (FoxO3a) downstream antioxidant response and diminishes A-induced mitochondrialpotential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit A-induced neurotoxicity.
Bee on flower of a almond in spring
PMID: J Neuroimmunol. 2016 May 15 ;294:6-13. Epub 2016 Mar 14. PMID: 27138092 Abstract Title: Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. Abstract: Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, anti-allergy, and anti-cancer effects. In the present study, we explored the prophylactic and therapeutic effects of hydrogen-rich water (HRW) on the progress of experimental autoimmune encephalomyelitis (EAE), the animal model for MS. We found that prophylactic administration of both 0.36mM and 0.89mM HRW was able to delay EAE onset and reduce maximum clinical scores. Moreover, 0.89mM HRW also reduced disease severity, CNS infiltration, and demyelination when administered after the onset of disease. Furthermore, HRW treatment prevented infiltration of CD4(+) T lymphocytes into the CNS and inhibited Th17 cell development without affecting Th1 cell populations. Because HRW is non-toxic, inexpensive, easily administered, and can readily cross the blood-brain barrier, our experiments suggest that HRW may have great potential in the treatment of MS.
PMID: J Surg Res. 2018 Aug ;228:238-246. Epub 2018 Apr 11. PMID: 29907217 Abstract Title: Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. Abstract: BACKGROUND: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly understood. The purpose of our study was to evaluate the neuroprotective role of hydrogen-rich water in rats with TBI and to elucidate the possible mechanisms underlying its effects.MATERIALS AND METHODS: The TBI model was constructed according to the modified Feeney weight-drop method. In part 1 of the experiment, we measured oxidative stress levels by observing the changes in catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) expressions. We also evaluated nuclear factor erythroid 2-related factor 2 (Nrf2) levels to determine the role of the protein in the neuroprotective effects against TBI. In part 2, we verified the neuroprotective effects of hydrogen-rich water in TBI and observed its effects on Nrf2. All the experimental rats were divided into sham group, TBI group, and TBI + hydrogen-rich water-treated (TBI + HW) group. We randomly chose 20 rats from each group and recorded their 7-d survival rates. Modified neurological severity scores were recorded from an additional six rats per group, which were then sacrificed 24 h after testing. Spectrophotometry was used to measure GPx, CAT, and MDA levels, whereas western blotting, reverse transcription polymerase chain reaction, and immunohistochemistry were used to measure the expression of Nrf2 and downstream factors like heme oxygenase 1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).RESULTS: GPx and CAT activity was significantly decreased, and MDA content was increased in the TBI group compared with the sham group at 6 h after TBI. MDA content peaked at 24 h after TBI. Nrf2 nucleoprotein levels were upregulated in the TBI group compared with the sham group and peaked at 24 h after TBI; however, no significant changes in Nrf2 mRNA levels were noted after TBI. Hydrogen-rich water administration significantly increased 7-d survival rates, reduced neurologic deficits, and lowered intracellular oxidative stress levels. Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.CONCLUSIONS: Our results indicate that hydrogen-rich water has neuroprotective effects against TBI by reducing oxidative stress and activating the...
PMID: Med Gas Res. 2012 ;2:12. Epub 2012 Jul 12. PMID: 22520831 Abstract Title: Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Abstract: BACKGROUND: Muscle contraction during short intervals of intense exercise causes oxidative stress, which can play a role in the development of overtraining symptoms, including increased fatigue, resulting in muscle microinjury or inflammation. Recently it has been said that hydrogen can function as antioxidant, so we investigated the effect of hydrogen-rich water (HW) on oxidative stress and muscle fatigue in response to acute exercise.METHODS: Ten male soccer players aged 20.91.3years old were subjected to exercise tests and blood sampling. Each subject was examined twice in a crossover double-blind manner; they were given either HW or placebo water (PW) for one week intervals. Subjects were requested to use a cycle ergometer at a 75% maximal oxygen uptake(VO2) for 30min, followed by measurement of peak torque and muscle activity throughout 100 repetitions of maximal isokinetic knee extension. Oxidative stress markers and creatine kinase in the peripheral blood were sequentially measured.RESULTS: Although acute exercise resulted in an increase in blood lactate levels in the subjects given PW, oral intake of HW prevented an elevation of blood lactate during heavy exercise. Peak torque of PW significantly decreased during maximal isokinetic knee extension, suggesting muscle fatigue, but peak torque of HW didn't decrease at early phase. There was no significant change in blood oxidative injury markers (d-ROMs and BAP) or creatine kinease after exercise.CONCLUSION: Adequate hydration with hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function. Although further studies to elucidate the exact mechanisms and the benefits are needed to be confirmed in larger series of studies, these preliminary results may suggest that HW may be suitable hydration for athletes.
PMID: J Plant Physiol. 2015 Mar 1 ;175:174-82. Epub 2014 Nov 18. PMID: 25543863 Abstract Title: Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities. Abstract: The aim of the present paper was to understand the specific mechanism of hydrogen-rich water (HRW) in alleviating cadmium (Cd) toxicity in Chinese cabbage (Brassica campestris spp. chinensis L.). Our results showed that the addition of 50% saturation HRW significantly alleviated the Cd toxic symptoms, including the improvement of both root elongation and seedling growth inhibition. These responses were consistent with a significant decrease of Cd accumulation in roots and shoots, which was further confirmed by the histochemical staining. Molecular evidence illustrated that Cd-induced up-regulations of IRT1 and Nramp1 genes, responsible for Cd absorption, were blocked by HRW. By contrast, Cd-induced up-regulation of the HMA3 gene, which regulates Cd sequestration into the root vacuoles, was substantially strengthened by HRW. Furthermore, compared with those in Cd stress alone, the expressions of HMA2 and HMA4, which function in the transportation of Cd to xylem, were repressed by co-treatment with HRW. HRW enhanced the activities of antioxidant enzymes, including superoxide dismutase, guaiacol peroxidase, catalase and ascorbate peroxidase. These results were further confirmed by the alleviation of oxidative damage, as indicated by the decrease of thiobarbituric acid reactive substances (TBARS) and reactive oxygen species (ROS) production. Taken together, these results suggest that the improvement of Cd tolerance by HRW was associated with reduced Cd uptake and increased antioxidant defense capacities. Therefore, the application of HRW may be a promising strategy to improve Cd tolerance of Chinese cabbage.
PMID: Brain Res. 2015 Jul 30 ;1615:129-138. Epub 2015 Apr 25. PMID: 25920370 Abstract Title: Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Abstract: Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate whether HRW could moderate parvalbumin and hippocalcin expression during ischemic brain injury and glutamate toxicity-induced neuronal cell death. Focal brain ischemia was induced in male Sprague-Dawley rats by middle cerebral artery occlusion (MCAO). Rats were treated with H2O or HRW (6 ml/kg per rat) before and after MCAO, and cerebral cortical tissues were collected 1, 7 and 14 days after MCAO. Based on our results, HRW treatment was able to reduce brain infarct volume and improve neurological function following ischemic brain injury. In addition, HRW prevented the ischemia-induced reduction of parvalbumin and hippocalcin levels in vivo and also reduced the glutamate toxicity-induced death of neurons, including the dose-dependent reduction of glutamate toxicity-associated proteins in vitro. Moreover, HRW attenuated the glutamate toxicity-induced elevate in intracellular Ca(2+) levels. All these results suggest that HRW could protect against ischemic brain injury and that the maintenance of parvalbumin and hippocalcin levels by HRW during ischemic brain injury might contribute to the neuroprotective effects against neuron damage.
PMID: J Hazard Mater. 2014 Feb 28 ;267:40-7. Epub 2013 Dec 27. PMID: 24413050 Abstract Title: Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production. Abstract: One of the earliest and distinct symptoms of aluminum (Al) toxicity is the inhibition of root elongation. Although hydrogen gas (H2) is recently described as an important bio-regulator in plants, whether and how H2 regulates Al-induced inhibition of root elongation is largely unknown. To address these gaps, hydrogen-rich water (HRW) was used to investigate a physiological role of H2 and its possible molecular mechanism. Individual or simultaneous (in particular) exposure of alfalfa seedlings to Al, or a fresh but not old nitric oxide (NO)-releasing compound sodium nitroprusside (SNP), not only increased NO production, but also led to a significant inhibition of root elongation. Above responses were differentially alleviated by pretreatment with 50% saturation of HRW. The addition of HRW also alleviated the appearance of Al toxicity symptoms, including the improvement of seedling growth and less accumulation of Al. Subsequent results revealed that the removal of NO by the NO scavenger, similar to HRW, could decrease NO production and alleviate Al- or SNP-induced inhibition of root growth. Thus, we proposed that HRW alleviated Al-induced inhibition of alfalfa root elongation by decreasing NO production. Such findings may be applicable to enhance crop yield and improve stress tolerance.
n/a PMID: Res Sports Med. 2014 ;22(1):49-60. PMID: 24392771 Abstract Title: Hydrogen-rich water affected blood alkalinity in physically active men. Abstract: Possible appliance of effective and safe alkalizing agent in the treatment of metabolic acidosis could be of particular interest to humans experiencing an increase in plasma acidity, such as exercise-induced acidosis. In the present study we tested the hypothesis that the daily oral intake of 2L of hydrogen-rich water (HRW) for 14 days would increase arterial blood alkalinity at baseline and post-exercise as compared with the placebo. This study was a randomized, double blind, placebo-controlled trial involving 52 presumably healthy physically active male volunteers. Twenty-six participants received HRW and 26 a placebo (tap water) for 14 days. Arterial blood pH, partial pressure for carbon dioxide (pCO2), and bicarbonates were measured at baseline and postexercise at the start (day 0) and at the end of the intervention period (day 14). Intake of HRW significantly increased fasting arterial blood pH by 0.04 (95% confidence interval; 0.01 - 0.08; p<0.001), and postexercise pH by 0.07 (95% confidence interval; 0.01 - 0.10; p = 0.03) after 14 days of intervention. Fasting bicarbonates were significantly higher in the HRW trial after the administration regimen as compared with the preadministration (30.5 1.9 mEq/L vs. 28.3 2.3 mEq/L; p<0.0001). No volunteers withdrew before the end of the study, and no participant reported any vexatious side effects of supplementation. These results support the hypothesis that HRW administration is safe and may have an alkalizing effect in young physically active men.
PMID: Toxicol Appl Pharmacol. 2014 Oct 1 ;280(1):169-76. Epub 2014 Jun 24. PMID: 24967689 Abstract Title: Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Abstract: Chronic exposure to low-levels of organophosphate (OP) compounds, such as chlorpyrifos (CPF), induces oxidative stress and could be related to neurological disorders. Hydrogen has been identified as a novel antioxidant which could selectively scavenge hydroxyl radicals. We explore whether intake of hydrogen-rich water (HRW) can protect Wistar rats from CPF-induced neurotoxicity. Rats were gavaged daily with 6.75mg/kg body weight (1/20 LD50) of CPF and given HRW by oral intake. Nissl staining and electron microscopy results indicated that HRW intake had protective effects on the CPF-induced damage of hippocampal neurons and neuronal mitochondria. Immunostaining results showed that the increased glial fibrillary acidic protein (GFAP) expression in astrocytes induced by CPF exposure can be ameliorated by HRW intake. Moreover, HRW intake also attenuated CPF-induced oxidative stress as evidenced by enhanced level of MDA, accompanied by an increase in GSH level and SOD and CAT activity. Acetylcholinesterase (AChE) activity tests showed significant decrease in brain AChE activity after CPF exposure, and this effect can be ameliorated by HRW intake. An in vitro study demonstrated that AChE activity was more intense in HRW than in normal water with or without chlorpyrifos-oxon (CPO), the metabolically-activated form of CPF. These observations suggest that HRW intake can protect rats from CPF-induced neurotoxicity, and the protective effects of hydrogen may be mediated by regulating the oxidant and antioxidant status of rats. Furthermore, this work defines a novel mechanism of biological activity of hydrogen by directly increasing the AChE activity.
Legalizing marijuana in the United States is a consistent debate. Its recently seen an interesting development with a 2018 Gallup poll, however, in which it was revealed that 64% of American citizens support the legalizations. If you happen to be interested in the debate on cannabis use, try reading about these women who have dedicated... View Article
The post Introducing the Weed Nuns and Their Faith in the Healing Powers of Cannabis appeared first on Healthy Holistic Living.
PMID: Ecotoxicol Environ Saf. 2014 Jul ;105:103-11. Epub 2014 May 7. PMID: 24793520 Abstract Title: Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings. Abstract: In this report, the effect of hydrogen-rich water (HRW), which was used to investigate the physiological roles of hydrogen gas (H2) in plants recently, on the regulation of plant adaptation to mercury (Hg) toxicity was studied. Firstly, we observed that the exposure of alfalfa seedlings to HgCl2 triggered production of reactive oxygen species (ROS), growth stunt and increased lipid peroxidation. However, such effects could be obviously blocked by HRW. Meanwhile, significant decreases in the relative ion leakage and Hg accumulation were observed. Hg-induced increases in total and isozymatic activities of superoxide dismutase (SOD) were significantly reversed by HRW. Further results suggested that HRW-induced the activities of guaiacol peroxidase (POD) and ascorbate peroxidase (APX), two hydrogen peroxide-scavenging enzymes, was at transcriptional levels. Meanwhile, obvious increases of the ratios of reduced/oxidized glutathione (GSH), homoglutathione (hGSH), and ascorbic acid (AsA) and corresponding gene expression were consistent with the decreased oxidative damage in seedling roots. In summary, the results of this investigation indicated that HRW was able to alleviate Hg toxicity in alfalfa seedlings by (i) alleviating growth stunt and reducing Hg accumulation, and (ii) avoidance of oxidative stress and reestablishment of redox homeostasis.
PMID: BMC Complement Altern Med. 2014 Mar 3 ;14:81. Epub 2014 Mar 3. PMID: 24589018 Abstract Title: Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. Abstract: BACKGROUND: Hydrogen has been reported to relieve damage in many disease models, and is a potential additive in drinking water to provide protective effects for patients as several clinical studies revealed. However, the absence of a dose-response relationship in the application of hydrogen is puzzling. We attempted to identify the dose-response relationship of hydrogen in alkaline electrolyzed drinking water through the aspirin induced gastric injury model.METHODS: In this study, hydrogen-rich alkaline water was obtained by adding H2 to electrolyzed water at one atmosphere pressure. After 2 weeks of drinking, we detected the gastric mucosal damage together with MPO, MDA and 8-OHdG in rat aspirin induced gastric injury model.RESULTS: Hydrogen-dose dependent inhibition was observed in stomach mucosal. Under pH 8.5, 0.07, 0.22 and 0.84 ppm hydrogen exhibited a high correlation with inhibitory effects showed by erosion area, MPO activity and MDA content in the stomach. Gastric histology also demonstrated the inhibition of damage by hydrogen-rich alkaline water. However, 8-OHdG level in serum did not havesignificant hydrogen-dose dependent effect. pH 9.5 showed higher but not significant inhibitory response compared with pH 8.5.CONCLUSIONS: Hydrogen is effective in relieving the gastric injury induced by aspirin-HCl, and the inhibitory effect is dose-dependent. The reason behind this may be that hydrogen-rich water directly interacted with the target tissue, while the hydrogen concentration in blood was buffered by liver glycogen, evoking a suppressed dose-response effect. Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.
Look at it this way. The kid doesnt have to pay for drugs out of his pocket. He gets them in a shrinks office. Insurance covers it.
His parents may be able to work a Social Security disability claim and receive $$ and other free medical treatments.
The kids school cashes in. Theyre now teaching a disabled child. Government aid.
No wonder Health Day News (4/24/14) reports that 1 in 13 American children are now on at least one psychiatric medication.
In 2012, the Archives of General Psychiatry reported a 7-fold increase in psychiatrists prescribing (powerful and toxic) antipsychotic meds to children, based on an analysis of office visits. (see also this.)
PMID: Food Chem. 2014 Aug 1 ;156:100-9. Epub 2014 Jan 30. PMID: 24629944 Abstract Title: Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit. Abstract: The effect of hydrogen-rich water (HRW) on prolonging the shelf life of kiwifruit and possible underlying mechanisms were assessed. Our results revealed that HRW (30%, 80%, and 100%) displayed different effects in inhibiting the rot of kiwifruit. Among these treatments, 80% HRW had the most significant effect by decreasing the rot incidence and preserving the firmness of kiwifruit. This conclusion was supported by the fact that 80% HRW treatment could effectively alleviate pectin solubilization and reduce the activities of cell wall-degrading enzymes. On the other hand, HRW treatment was able to reduce the respiration intensity, increase the activity of superoxide dismutase, decrease lipid peroxidation level, and maintain the radical (DPPH,O2(-),andOH)-scavenging activity of kiwifruit. Moreover, the inner membrane of mitochondria exhibited higher integrity. Thus, our results demonstrate that HRW treatment could delay fruit ripening and senescence during storage by regulating the antioxidant defence.
PMID: Int Immunopharmacol. 2014 Jul ;21(1):94-101. Epub 2014 Apr 29. PMID: 24793096 Abstract Title: Effect of hydrogen-rich water on acute peritonitis of rat models. Abstract: OBJECTIVE: To study the effect of hydrogen-rich water (HRW) on acute peritonitis with three different rat models.METHODS: Acute peritonitis was induced by three methods including intraperitoneal injection of lipopolysaccharide (LPS), rats' feces or cecal ligation and puncture (CLP) operation. For each model, male Sprague Dawley rats were used and distributed into saline control group, HRW control group, saline plus model group, and HRW plus model group. Saline or HRW (3 ml per rat) was orally administered by gavage for 7 days beforehand and 3 days after modeling. The efficacy was tested by detecting concentrations of white blood cells (WBCs), plasma endotoxin, interleukin (IL)-6 and tumor necrosis factor (TNF)-. The activities of malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) in visceral peritoneum tissues were also evaluated. Meanwhile, histopathology examination of visceral peritoneum was performed using hematoxylin and eosin staining. The expression and location of nuclear factorkappaB (NF-B) in the visceral peritoneum were detected by immunohistochemistry.RESULTS: Three models showed the same result that hydrogen-rich water had an efficient protective effect on acute peritonitis. HRW could significantly lower the levels of WBCs, plasma endotoxin and cytokines, enhance GSH activity and reduce MPO and MDA activities in the peritoneum tissue when compared with that of groups with only saline treated. Simultaneously, we found that HRW could also decrease the NF-B expression in the peritoneum tissues.CONCLUSION: Hydrogen-rich water could alleviate the severity of acute peritonitis, and it might perform this function by its anti-inflammation, anti-oxidation and anti-bacterial effects and reducing NF-B expression in the peritoneum tissues.
Have you ever wondered why you should start your own garden when food is readily available at grocery stores? What about those who would love to be self-sufficient to the point of living off the food they can grow on their own land? The simple answer is yes, this is possible, but it will take hard work and dedication.
Most Americans firmly believe its impossible to be self-sufficient, and those values are all but permanently engrained into their minds from a young age. Even people who know that organic agriculture is just as productive as industrial agriculture often think you need to have acres and acres of land to grow all of your own food. But that simply is not true. According to the Small Footprint Family, applying certain techniques and principles can get you set on the lifetime journey of potentially being able to grow all your food on as little as a quarter of an acre! Even people in most suburbs could give this a try!
Obviously, how much food you need and c...
By Sara Tipton
Vaseline is often found in medicine cabinets across the United States. But have you ever thought of adding some to your prepping gear? It actually can be useful in a survival situation and offers many benefits to those who store extra for when the SHTF. And if youre a more natural prepper, weve got a few alternatives to Vaseline for you that are just as good, if not better!
Petroleum jelly is the generic name of Vaseline. It is a lubricant and is a byproduct of the petroleum industry. Surprisingly, Vaseline is an organic product. It was originally discovered on the bottom of oil rigs and is often used to prevent or heal dry flaky skin. Vaseline is highly-refined, triple-purified, and regarded as non-carcinogenic. Other brands may not be as pure, and many dermatologists suggest sticking with the original name brand to avoid possible contamination of cancer-causing chemicals.
Vaseline is water-repellant and not water-soluble. That means it will seal the barrier so that moisture does not leave the skin. If youve ever had such dry skin that its cracked and bled, you know that feeling of instant gratification when you slather on an antiseptic thats also a moisture barrier such as Neosporin (which contains three antibiotic ingredients in a petroleum jelly base.) Even though its considered safe to use, if you can access other options for your dry skin concerns, it is recommended to do so. Products containing beeswax, cocon...
Check out this powerful health documentary thats already been seen and shared by millions and you can watch it ALL for FREE, in its entirety, when you sign-up! RELATED STORY: Type 1 Diabetes on the rise in young children: Is anyone paying attention? <<<<<<<<<<Click here to enter your first name and best email address and 
Healthcare is a rapidly growing industry, representing 12 of the 30 fastest growing jobs in any profession, so whether youre new to the work world or just looking for a change, healthcare is home to exciting prospects. To get an interview, though, first youre going to have to get the skills. Despite its growth, healthcare is highly competitive and requires specialized education, even for entry-level jobs, so look into licensing guidelines.
With the right skills under your belt, any of these four exciting careers could be yours.
In recent years, aging adults have expressed a strong preference for aging in place remaining in their homes when they might otherwise transition to assisted living facilities or nursing homes. In order to make this shift, however, healthcare needs to become less centralized, and that means we need more home health aides.
According to the Bureau of Labor Statistics (BLS), this single field could see a 46.7% increase through 2026, which is over 425,000 new positions. Working as a home health aide can be a very physical job, but its also intimate and could be the perfect fit for young people who enjoy close social interaction as part of their work.
Last time you went to the doctor, you may have noticed that your old paper records had been replaced by a digital system or electronic healthcare records (EHRs). These systems are the new gold standard in record keeping, making it simpler for providers to communicate with patients and with each other, and to transfer records between locations. In order to keep them up and running, though, EHRs require a new class of tech professionals.
Medical records technicians (MRTs) manage records, including their ICD-10 coding, and perform system maintenance...
Moringa oleifera is a plant with many health benefits due to its antioxidants, anti-inflammatory and antimicrobial properties. Moringa powder supplements help fight inflammation and pain, keep your heart healthy, and promote good liver health. You can also drink moringa tea to improve cognitive function, boost your digestive health, and even assist in losing weight.
Because moringa powder and tea are so good for your health, moringa is sometimes called the miracle tree. Moringa leaves contain high levels of vitamin C, vitamin A, calcium, potassium, and iron. The rich nutritional value of the moringa plant leads many people to class moringa as a superfood.
In this article, you will learn about the scientifically proven health benefits of taking moringa powder or drinking moringa leaf tea.
Please read on to see how moringa can help you lose weight, prevent the symptoms of diabetes, boost cardiovascular health, and treat depression.
Moringa oleifera is a tropical tree that grows in the Himalayan Mountains in northern India. Moringa is also called the drumstick tree, horseradish tree, miracle tree, ben oil tree, or malunggay.
Research into the health benefits of moringa has shown that moringa leaf is rich in vitamins, minerals, and essential phytochemicals (plant-based antioxidants). The medicinal properties of moringa have been linked to preventing cancer, treating infection, managing diabetes, and improving nutrition. (1)
The amazing thing about the moringa tree is that each part of the tree can be used to treat various health conditions.
The journal Nutrients reported that each part of the Moringa oleifera plant has antimicrobial properties, each with their own use. (2)
Moringa leaves. The most nutritious part of the moringa plant is the leaves. You can eat moringa leaves like spinach or powder them and add to sauces, soups, and smoothies.
Scientific research has shown that leaves from the moringa plant are rich in minerals such as calcium, magnesium, iron, and potassium. The drumstick plant also contains vitamins A, C, D, E, K, and B-group vitamins. In fact, moringa leaves have more than double the amount of calcium than milk! (1...
Pack your bags ladies, were relocating into nature! Our prayers for finding the fountain of youth have been answered! Ok, well maybe not entirely the fountain of youth, BUT, hear me out. Recent studies have confirmed that women who surround themselves in or live within nature, live longer! Research has shown that stress reduction, as... View Article
The post New Study: Women Live Longer If They Live Surrounded By Nature appeared first on Healthy Holistic Living.
Everyone knows how much joy animals can bring to our lives. Dogs, cats, birds, and all other kinds of animals have made their ways through time into our homes as regular pets, and we love having them there. Terms like fur babies or paw parent are popular terms used by millions of people to describe... View Article
The world is a large and mysterious place. So many mysteries surround nature and were only just barely beginning to understand what anything really means. Scientists are constantly making new discoveries about the oceans, the deserts, and even the plant life on our home, Earth. There is so much to learn that at times it... View Article
The post When, Where and How To Enjoy the Upcoming Orionid Meteor Shower appeared first on Healthy Holistic Living.
Sometimes we get so intertwined in our own lives that we forget how other people live different, far more complicated lifestyles. Living in the city, for instance, is far different than living on a farm! These two radically different ways of living have practically nothing in common, other than the typical getup, get ready, go... View Article
When I was a kid, I used to watch a lot of TV. On the TV shows and movies that ran late at night, it wasnt uncommon to see cars that were able to fly and drive in the water like they were a boat. This captured my imagination as a kid. The possibilities of... View Article
The post An Exciting New Invention A Foldable Shuttle Bike Kit appeared first on Healthy Holistic Living.
October is a wonderful time of year! Its officially Autumn and the weather is finally getting colder. For some of us, that means fuzzy socks, cozy sweaters, hot cocoa, and fireside evenings, but for others it simply means soup. Soup is many peoples favorite food, but they can only eat it certain times of the... View Article
Confession time: I hate spiders. I am terrified of them. While logically I understand that regular little spiders in my home or out in nature are fine, there is something creepy and scary about them. I am terrified of them, and it is only getting worse as I get older. Why Killing Spiders Is A... View Article
The post Should I Kill Spiders In My Home? An Entomologist Explains Why Not To appeared first on Healthy Holistic Living.
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