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Friday, 17 November

03:10

WHO asks dozens of journals to correct papers on diagnostic tool developed by former collaborators Retraction Watch

In one of the largest such requests weve ever heard of, the World Health Organization has asked 46 journals to correct articles that refer to a bone fracture risk diagnostic tool as developed or endorsed by the WHO. By WHOs count, the tool known as Fracture Risk Assessment Tool (FRAX), which has come under []

The post WHO asks dozens of journals to correct papers on diagnostic tool developed by former collaborators appeared first on Retraction Watch.

02:53

Link new research findings two

DTP vaccine INCREASES the death rate by 5 to 10 times compared to unvaccinated children, study reveals


...

02:37

California City Forces Church To Stop Feeding The Homeless REALfarmacy.com

Source: California City Forces Church To Stop Feeding The Homeless For more content like this visit REALfarmacy.com.

As children, we were taught to abide by the Golden Rule: do unto others as you would have them do unto you. As adults, we are now being instructed to not help people who are down on their luck. What changed? The question is relevant, as recently, the United Methodist Church in Malibu, was asked []

Source: California City Forces Church To Stop Feeding The Homeless Learn more at REALfarmacy.com - Healthy News and Information.

02:36

Bega Valley. COMMENT: Greed, stupidity and mismanagement destroying Sapphire Coasts gems Fluoride Action Network

Tathra local Greg Otton spoke out at the recent council meeting against the fluoridation of the shires water supplies, but also what he sees is the destruction of the regions pristine natural gifts. An excerpt of an opinion piece he has submitted is below. Gregs views  do not necessarily represent those of Fairfax, but we put this forward as a topic for readers to discuss. 

There are so many precious gems that the Sapphire Coast provides us with. Especially the life giving pristine water supplies of the Kiah, Tantawangalo, Brogo Dam catchments and the Bega Aquifer. The many natural gifts of this area are all being destroyed, mismanaged or are under threat by the bureaucratic decisions usually in the name of the dollar, progress, growth or just pure greedy stupidity.

Let me list the gems I have personally seen decimated by humanitys greed, lust and plain stupidity. I lost over 50% of my oyster leases to siltation yet my voice went unheard, I was ridiculed by successive councillors of this shire.

I have worked for over 35 years in the once lucrative abalone industry. Worth at one time $35million to the Far South Coast. A line in the sand on Cape Howe divides a 22 tonne Victorian quota from a 2 tonne NSW quota, same water, same seasons, just different management.

The tuna industry was decimated in a few years by greed and mismanagement.

The timber industrys once thriving saw mills all but gone. The chip mill is in its death throws after destroying the south-east forests and silting up major rivers and coastal estuaries.

The famous Pambula river mouth surf break is all but gone due to development of its catchment.

The millions of dollars spent by the dairy industry on noxious weeds and pests within the shire.

The decimation of migrating birds from the other side of the world by foxes and cats along our local beaches.

How much do we pay for Bega Cheese with irrigation draining our rivers, nutrient runoff and toxic chemicals used by farming?

The 15km of gravel shire roads that are graded each day using dubious practices with limited siltation runoff protections.

The wanton development of coastal villages. Do they end in the next town or the next shire?

What is the exact purpose for the shark buoy in Merimbula bay? Does the government think this will really help the shark menace that is rapidly escalating along our coast?

More attacks will come just as I predicted and warned the swimmer that was taken in Tathra. Do not call her death the result of a three metre Bronze Whaler. It was an eight to nine metre Great White that killed her, it has lurked along our coast now for years and utilises the best location in Tathra bay as its dominance over many others.

National parks and fisheries have withheld knowledge of Great White activity from local surfers for some stupid reason.

I have 35 years experience in the abal...

02:32

Human rights issues bite in fluoride test case, top court told Fluoride Action Network

A group fighting the fluoridation of drinking water supplies in court has argued tooth decay is not serious enough to warrant imposing it on a whole community. Ann Marie May reports.

Opponents of adding fluoride to water supplies say it breaches human rights to protect against unwanted medical treatment, a Supreme Court test case has been told.

Two small Taranaki towns, Waverley and P?tea, are at the centre of the case after the South Taranaki District Council decided to add fluoride to their water supplies.

?New Health New Zealand has taken on the council and the minister of health, and says fluoridating water supplies breaches the right to be able to refuse to undergo medical treatment.

New Healths lawyer, Mary Scholtens, QC, said about 48 per cent of New Zealands water was fluoridated at present, without proof that fluoride was effective against tooth decay.

The chemicals used to fluoridate water were byproducts of an industrial process, and could contain contaminants such as arsenic, mercury and lead. It was a different grade from fluoride in toothpaste, or pharmacy-only medicines fluoride tablets.

One of the points in the appeal was whether fluoride was a medicine, and whether adding it to a water supply would amount to medical treatment. Under the Bill of Rights, medical treatment can be refused, subject only to reasonable limits.

Scholtens said water supplies should not be fluoridated unless the law clearly authorised it. Currently the authority to fluoridate was reached by a complex process, including reference to a Privy Council decision in 1965.

This is medicating water, the drinking water is just the method by which the medicine is delivered, and nowhere is that authorised.

The emphasis should be on determining for ourselves what we did with our bodies, she said.

Tooth decay posed no risk to third parties and was a manageable risk to the individual, so it was for the council to show why the right to refuse medical treatment needed to be limited to add fluoride to the water supply.

It was not settled that fluoridating water was a safe and effective way to prevent tooth decay, Scholtens said. The jury is still out on that.

Another of New Healths lawyers, Lisa Hansen, said 500ml of water from a fluoridated supply gave the equivalent to a fluoride tablet that was a pharmacyonly medicine.

The case is due to finish on Friday.

*To listen to interview or read the original article go to https://www.stuff.co.nz/national/health/98936426/fluoridation-raises-medical-treatment-rights-in-supreme-court-case

...

02:19

Burton: Arguments made for both sides at public hearing on water fluoridation Fluoride Action Network

BURTON People voiced strong opinions both for and against the fluoridation of water at a recent public hearing held at the Genesee County Drain Commissioners office (GCDC) Nov. 8. Drinking water at GCDCs newly built treatment plant connected to the Karegnondi Water Authority (KWA) pipeline has been test-treated, and GCDC plans to begin distribution of water to clients in the next several weeks. In order to cease the addition of fluoride in the water, there must be either a vote by the Genesee County Board of Commissioners or the passage of a referendum ballot question instructing GCDC to do so.

John OBrien, director of the water and waste division at the GCDC office, who was facilitator of the public hearing, said this would affect the communities which receive water from the water supply district: Flushing Township, the city of Flushing, Richfield Township, Flint Township, Burton, Davison Township, Swartz Creek and Grand Blanc Township, as well as 11 other municipalities.

Carol Lutey, director of pediatric dentistry at Mott Childrens Health Center, said they were seeing a huge increase in more aggressive tooth decay since Flint has not had a fluoridated water system, and very young children were being taken to the operating room because of the decay. She also said, as one who did not have benefits of fluoridated water, she experienced all types of large decay throughout her life.

Dr. Mark Fitzgerald, associate dean of the University of Michigan School of Dentistry, quoted the surgeon generals report on public and oral health in America, saying there were reductions in dental caries (called cavities or decay) in communities with fluoridated water, with the reductions being as high as 40 percent.

More than 51 million school hours are lost each year due to the consequences of dental caries, Fitzgerald said. Pain and suffering due to untreated diseases lead to problems in eating, speaking and attention to learning. Lost time from dental problems in adults resulted annually in over a billion dollars of lost wages, and to have good health, a person needs healthy teeth.

Dr. Gerald Natzke, who practices medicine in Grand Blanc, said fluoride does not benefit the teeth unless it touches them. He added that most developed countries do not fluoridate their water, and these countries do not have any more tooth decay than the United States. He said many tissues in the body develop disease, and these are magnified by fluoride. He also said 40 percent of American teenagers show signs of overexposure to fluoride, which causes discoloration of the teeth.

Natzke, offering several statistics of dental decay in communities with fluoridated water, claimed fluoridation does not decrease tooth decay, but increases it. David Joyce, a Kung Fu instructor who said he just wants clean water, said fluoridating water is mass medication, and when a government entity decides to fluoridate water, th...

01:50

10 Reasons Why the Las Vegas Shooting Has Disappeared from Headlines REALfarmacy.com

Source: 10 Reasons Why the Las Vegas Shooting Has Disappeared from Headlines For more content like this visit REALfarmacy.com.

With the 24/7 news cycle constantly in full swing, important stories at times get lost in the constant onslaught of non-stop information. The mainstream media gatekeepers essentially dictate what social and cultural memes are injected into the public consciousness, what topics are discussed, and which cases are given publicity and thoroughly investigated with journalistic rigor. []

Source: 10 Reasons Why the Las Vegas Shooting Has Disappeared from Headlines Learn more at REALfarmacy.com - Healthy News and Information.

01:42

Essentia Health To Let Go Of Flu Shot Refusers By Monday Vaxxter

When it comes to mandatory vaccinations, we often relate the term with school children. But mandatory vaccine requirements are a large part of the healthcare culture. And more and more health workers are finding it...

The post Essentia Health To Let Go Of Flu Shot Refusers By Monday appeared first on Vaxxter.

01:00

CAM use leads to delays in appropriate, effective arthritis therapy Science-Based Medicine

A preference to use CAM before seeking medical advice may be harming patients with inflammatory arthritis.

00:00

A physics journal agreed to retract a paper several months ago. Its still not retracted. Retraction Watch

A physics journal says it has planned for several months to retract a 2006 paper by a prominent researcher with multiple retractions, after a concerned reader notified the editor about extensive duplication. But, more than seven months after receiving the complaint, the journal Thin Solid Films has not yet taken action. So whats taking so []

The post A physics journal agreed to retract a paper several months ago. Its still not retracted. appeared first on Retraction Watch.

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Thursday, 16 November

23:32

75 Percent of Reishi Supplements Don't Actually Contain Reishi Mushroom PreventDisease.com

Only a quarter of 19 supplement products labeled as Reishi mushroom purchased in the U.S. could be verified as genuine Reishi mushroom, says a new study that highlights quality issues in the category.

22:03

Psychologys Power Tools Mad In America

In this piece for Aeon, David A. Sbarra discusses the philosophy and science behind cognitive behavioral therapy and explains why it is so effective.

Importantly, emotions communicate information, prepare us for action, and have incredible survival value. Without a signalling system to warn us about potential threats in the natural world that is, without emotions to provide information humans and other animals would be toast. Quite often, our emotions become disordered when they are out of proportion to the demands of a given situation. Just think of someone who has a panic attack at the idea of being at Costco on a Saturday; it can be overwhelming for anyone, but it is not an emergency that should elicit an immediate and overwhelming fear response. Given the importance of emotions to our survival and the myriad ways in which they can become disordered, the goal of most psychotherapies is to recalibrate our emotional response system.

Over the course of my career, I have worked with many clients who just wanted to figure out how to eliminate every single one of their emotional reactions. Doc, if you had a pill that would stop me from feeling, Id take it in a heartbeat. Theres a simple and poignant response for such statements: if we eliminated the experience of physical pain, wed burn our hands off on a hot stove by dinnertime. The same goes for our emotions. Our goal should never be to eliminate our emotions, but rather to regulate or coexist with them better.

22:02

Raped by Carl Jung, Then Murdered by Nazis Mad In America

From Tablet Magazine: Angela Sells new book Sabina Spielrein: The Woman and the Myth describes the work and life of a pioneering psychoanalyst who challenged her contemporaries conventional ideas about women and female sexuality. As a Jewish woman and former mental patient, Spielrein faced marginalization in the psychoanlaytic world and the broader society; her work was stolen and erased by the Great Men of Psychoanalysis, and she was eventually murdered by the Nazis.

It is unbearable that Spielreins work was taken and used without crediting her; that her character was defamed by the Great Men who used her ideas without crediting her; and that she was unable to earn a living in Austria and in Switzerland because she was a woman; unable to continue her groundbreaking work in Moscow because she was a Jew; and was, eventually, in 1942, murdered by the Nazis.

In a heroic act of resistance against memoricide, Sells has begun Spielreins long-overdue resurrection. Angela Sells book is a major, perhaps a definitive, feminist contribution to the literature. Someone should make a movie about the real Sabina Spielrein.

Article

22:01

The Issue of Over-Diagnosing in Psychiatry Mad In America

From The Concordian: On October 30th, Dr. Joel Paris, a professor of psychiatry at McGill University, gave a lecture about the dangers and consequences of psychiatric over-diagnosis, an issue he says is pervasive today.

According to Paris, about 11 per cent of Canadians are currently on antidepressants. He said this number demonstrates that antidepressants are being over-prescribed, which is a consequence of over-diagnosis. People in my field are handing out prescriptions like its nobodys business when it comes to antidepressants, and antipsychotics too, he said.

According to Paris, over-diagnosis and over-prescribing in psychology and psychiatry has affected the way society views diagnoses of mental illness. He called it a diagnostic epidemic. As he explained, the problem lies in people discussing symptoms as if they were professionally-made diagnoses. The media picks this up and feeds these epidemics. People talk about these things, even socialize it, Paris said. The fact that it is common for people to declare, I think I have ADHD or my father is bipolar without a diagnosis exemplifies this, he added.

Article

22:00

Effects of Racism on Depression in Black College Women Mad In America

Buffie Longmire-Avital, Associate Professor of Psychology at Elon University, and alumna Ruthie Robinson, investigate the rates of depression in Black and White collegiate women. The results of their study, recently published in the Journal of College Student Psychotherapy, demonstrate that Black women experience more perceived stress and are more likely to endorse depressive symptoms than White peers. The authors highlight the impact of racism and minority stress on Black collegiate womens psychological well-being.

Where one in five White females in the current sample met criteria for MDD [Major Depressive Disorder], an alarming one in two Black females met criteria for MDD. Given that race is a social construction with no biological merit, this finding calls attention to the contextual sociological factors that are contributing to the development of the disease instead of the individual biological causes, write the researchers.

AMOR (Photo Credit: Artomatic For The People, 2017)

The researchers report, Depression is closely linked to the level of stress than an individual perceives and experiences in their daily life. Chronic stress, such as racial minority stress, can lead to physical and mental health problems.

The authors cite a study on low-income women finding various intersecting systems of oppression contribute to depressive symptomatology; specifically the womens experience with sexual objectification, racist events, and gender-racism. Research suggests that Black women are more likely to meet...

22:00

Learning About Psychiatric Drug Withdrawal Mad In America

By: Professor Peter C. Gtzsche, the Nordic Cochrane Centre; Pharmacist Birgit Toft; Pharmacist Bertel Rdinger; Child and adolescent psychiatrist Lisbeth Kortegaard; Psychologist Olga Runciman; and Psychologist Anders Srensen

We held the first course ever on psychiatric drug withdrawal on 12 June 2017 in Copenhagen. The course was open to patients, relatives, psychologists, doctors and other social and healthcare workers, and 77 people participated.

Our practical guides, an abstinence chart, a list of doctors and others willing to help with tapering, and the lectures (with English subtitles) are available from the front page of www.deadlymedicines.dk.

In October 2016, two of us were involved in co-founding the International Institute for Psychiatric Drug Withdrawal in Gteborg, Sweden, and this institute has also just finished its first course. At the Nordic Cochrane Centre, we do research on drug withdrawal, and everyone with an interest in this is most welcome.

Withdrawal courses are badly needed. About 5% of the inhabitants in Western countries have become dependent on psychiatric drugs and have difficulty getting help with tapering off them. Very few doctors know how to do it properly and the official recommendations are poor, e.g. to halve the dose when withdrawing from depression pills,1 which is much too fast.2 3 One can reduce withdrawal symptoms by reducing the dose by only 10 percentage points at a time, from 100% to 90%, and after another 2-4 weeks, to 80% of the usual dose, etc., perhaps with even smaller steps when the dose has been reduced to about 30%.

Often, the most difficult step is to go from a low dose to nothing, which to a considerable extent is a psychological barrier. The patient has often built their identity around a diagnosis with accompanying pill intake, and half of patients or more have been told that their mental disorder is due to a chemical imbalance in the brain. This is a myth, but it has the unfortunate effect that some patients are scared of becoming drug-free because they think they are chemically defective and that the drugs fix this.

Several patients had experienced being unable to get help with tapering, or psychiatrists dismissing them when they had tapered off the drugs on their own, but still wanted to stay in contact with psychiatry in order to get psychological support. A staff member in a group home (supported living facility) had asked what she should do if she wanted to supp...

17:00

Can You Stop Yourself From Blushing? Articles

By Dr. Mercola

When your face gets red after you've made an embarrassing mistake or social faux pas, or because you've suddenly been made the center of attention or seen someone you think is attractive, it can feel like your body is turning on you, giving away your innermost feelings to the world.

But blushing is a perfectly natural phenomenon, one that may even offer benefits in how others perceive you, and more. The pink tinge to your cheeks is the result of a sympathetic nervous system response to stress, embarrassment or other strong emotions.

Your sympathetic nervous system activates your fight-or-flight response, releasing the hormone adrenaline which, along with speeding up your heart rate and breathing, also causes your blood vessels and the veins in your face to dilate, increasing blood flow and oxygen throughout your body while also leading to the characteristic pink hue in your cheeks known as blushing.1

Blushing is an involuntary response, which means technically there's no way to stop it. However, that doesn't mean you can't try. There are many strategies you can use to try to stop a blush from coming on, or make it fade quicker if it does. Before I get to those, though, you might want to reconsider your desire to stop it.

Blushing May Not Deserve Such a Bad Rap

Despite the fact that virtually everyone blushes, scientists are still trying to figure out its purpose. One theory is that it offers remedial value in cases when youve done something wrong. While facial redness can occur due to environmental factors like changes in temperature, hot or spicy foods or drinking alcohol, blushing is most often triggered by feelings of self-consciousness, often in situations when a person feels embarrassed or shameful. Writing in the journal Emotion, researchers pointed out:2

"Several theorists have stressed the functional properties of expressing embarrassment and shame, and have argued that these expressions may help restore the actor's public image after a mishap or transgression. That is, publicly conveying embarrassment or shame may signify the actor's recognition that she/he has committed a social or moral infraction, and regrets this."

Blushing fits right in to the "publicly conveying embarrassment" theme, and when researchers showed study participants pictures of people with or without a blush, they evaluated them more favorably on items such as sympathy and trustworthiness when they were blushing. "Although people often consider blushing to be an undesirable response," the researchers concluded, "our results showed that, in the context of transgressions and mishaps, blushing is a helpful bodily signal...

What You Can Learn From Other Peoples Regrets Articles

By Dr. Mercola

Regrets. We all have them things said or done; things left unsaid or undone. Paths that werent followed; opportunities missed due to fear or insecurity. The list is long, but one of the biggest regrets in life reported by a large number of people is not being there for someone at the end of life.1 In other words, being too busy with life to tend to those near death.  

Interestingly, while a regret can be phrased either as an action or as an inaction (I wish I had not quit high school, versus I wish I had stayed in high school), regrets framed as actions tend to be more emotionally intense than regrets about inactions, but inactions tend to be longer lasting.2

Emma Freud, a columnist for The Guardian, recently explored themes of regret on social media, covering everything from relationships, work-life balance and personal passions, to addiction, illness and death. If youre so inclined, you can take a look at some of the thousands of responses she received.3 Chances are, youll recognize yourself in some of them.

Top Five Regrets of the Dying

According to Bronnie Ware, a former palliative care nurse who ended up writing a book, The Top Five Regrets of the Dying, based on her conversations with the dying, the biggest, most commonly cited regrets at the end of life are beginning with the most common regret of all:4

  1. Not having the courage to live a life true to oneself but rather doing what was expected
  2. Working too much, thereby missing childrens youth and their partners companionship
  3. Not having the courage to express ones feelings
  4. Not staying in touch with friends
  5. Taking life too seriously and allowing worries to diminish happiness

Ware goes a step further, however, in that she also delves into solutions for these regrets ways for you to avoid falling into the same traps. The No. 1 regret is a valuable reminder to not give up too many of your dreams to please others (or conform to conventional standards). It is very important to try and honor at least some of your dreams along the way, Ware says. From the moment that you lose your health, it is too late. Health brings a freedom very few realize, until they no longer have it.

Living Life on Your Own Terms Is Key to Dying Without (Too Many) Regrets

Virtually every man in Wares care listed No. 2: Missing out on family time because of e...

How Bacopa Can Help Improve Your Cognitive Function Articles

Bacopa (Bacopa monnieri), or moneywort, is a popular herb in Ayurvedic medicine that has been used in India for over three centuries. The bacopa herb is commonly known as a nootropic herb, which means that it can help repair damaged neurons and improve brain function. Nootropics are usually said to have the ability to "unlock" the brain when it comes to creativity and cognitive drive.1

In India, the bacopa herb falls under the category of the "Medhya Rasayana" herbs that have the ability to improve memory and intellect.2 This herb is also called "brahmi," together with the herb gotu kola. This was taken from the name of "Brahma," the creator of the universe in the Indian belief system. While the gotu kola herb shares the ability of the bacopa plant in improving cognition, these two can be easily differentiated based on their appearance.3

The gotu kola plant has fan-shaped leaves with slightly serrated edges, and produces purple to pink flowers.4 Bacopas, on the other hand, have succulent oblong leaves and white or light purple flowers.5 Bacopa monnieri also shares its name with the Bacopa caroliniana plant, which is widely cultivated in aquarium settings because of its blue flowers and aromatic leaves.

The two plants are closely related, but the Bacopa monnieri variety is much more known for its medicinal properties rather than its ornamental and decorative characteristics.6 Aside from being a nootropic, bacopa is an adaptogen and diuretic as well. Continue reading to learn more about the health benefits you can acquire from this herb.

Get These Impressive Health Benefits From Bacopa

Bacopa monnieri offers an impressive list of health and nutritional benefits, which are usually credited to the alkaloids, saponins and sterols that this herb contains.7 These benefits include the following:

May improve epilepsy symptoms. In Ayurvedic medicine, bacopa has been used to reduce the frequency of epileptic episodes.

In one study, the herb's effect on the GABA receptors, which are responsible for maintaining and regulating neuronal excitation, was measured. An imbalance in these receptors causes the abnormal occurrence of seizures. The use of bacopa showed a decrease in GABA receptor activity, decreasing the frequency of seizures...

15:09

Oral administration of Rutin for 28 days decreases blood glucose levels and prevented oxidative stress andantioxidant status in hyperglycaemic rats. GreenMedInfo

PMID:  Niger J Physiol Sci. 2017 Jun 30 ;32(1):91-96. Epub 2017 Jun 30. PMID: 29134983 Abstract Title:  Anti-hyperglycaemic Effects of Rutin on Blood Glucose, Oxidative Stress Biomarkers and Lipid Peroxidation in Alloxan-induced Hyperglycaemic Wistar Rats. Abstract:  The present study investigated the anti-hyperglycaemic effect of rutin on blood glucose, oxidative stressbiomarkers and lipid peroxidation in alloxan induced hyperglycaemic wistar rats. Diabetes was induced in rats by anintraperitoneal (i.p) injection of alloxan monohydrate 150 mg/kg body weight. Twenty five wistar rats were divided asfollows; Group1 served as diabetic control received distilled water 2 mg/kg, Group served as positive control received 2mg/kg glibenclamide, 3, 4 and 5 received rutin at 50, 100 and 200 mg/kg body weight for 28 days respectively. At the end of the treatment, rats were sacrificed and the blood and serum were used for the analysis of blood glucose and oxidativestress biomarkers respectively. The determinations of blood glucose levels were carried out at intervals of 7, 14, 21 and 28days respectively Serum oxidative stress biomarkers lipid peroxidation, were done on the 28 days. Administrations of rutinat the three different doses 50,100 and 200 mg/kg to diabetic rats significantly (p

read more

14:12

Psilocybin represents a promising paradigm for unresponsive depression. GreenMedInfo

PMID:  Psychopharmacology (Berl). 2017 Nov 8. Epub 2017 Nov 8. PMID: 29119217 Abstract Title:  Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Abstract:  RATIONALE: Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy.OBJECTIVES: Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression.METHODS: Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure.RESULTS: Treatment was generally well tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p 

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12:15

Peer-reviewed Scientific Literature Filled with Fake Science Health Impact News

corruption bribing fraud cash in hand image

PR firm offers to fake science

by Dr. David Lewis
Focus for Health

Excerpts:

Environmental groups in Wilmington, NC are trying to stop chemical companies from polluting their drinking water with perfluorochemicals, called PFCs, which are highly persistent and magnified up the food chain. They are an increasingly common contaminate in food, water and household dusts. DuPont de Nemours & Company, for example, discharges a PFC abbreviated PFOA.

Numerous studies have linked PFCs to genetic and reproductive damage, developmental problems in unborn children, and cancer. The scientific literature, therefore, contains ample evidence that chemical companies are to blame. In a letter to DuPont, The Weinberg Group, a leading public relations firm, offered to reshape the scientific literature.

The firm stated that it would construct a scientific study to establish that PFOA is safe and provides real health benefits. Constructing studies with predetermined outcomes is not science in any sense of the word. And any benefits reported in the scientific literature from such a study would be nothing but fake science.

Lewis-Column-10-19-17-PR-firm-fakes-science

Unfortunately, the peer-reviewed scientific literature is filled with fake science. During my tenure as a research scientist at EPA and the University of Georgia, I observed how politics and commercial interests often lead to science, and all of its very real benefits, being skewed to support government policies, industry practices and commercial products.

Read the full article at Focus for Health.

David Lewis is an internationally recognized research microbiologist whose work on public health and environmental issues, as a senior-level Research Microbiologist in EPAs Office of Research & Developme...

12:04

Electroacupuncture stimulation of the sensitized acupoint can improve diarrhea in D-IBS rats. GreenMedInfo

PMID:  Zhen Ci Yan Jiu. 2017 Oct 25 ;42(5):413-7. PMID: 29105469 Abstract Title:  [Effect of Electroacupuncture Stimulation of Sensitized Acupoints on Bowel Dysfunction in Rats with Diarrhea-predominant Irritable Bowel Syndrome]. Abstract:  OBJECTIVE: To investigate the effect of electroacupuncture(EA)stimulation of sensitized acupoints on bowel dysfunction in diarrhea-predominant irritable bowel syndrome(D-IBS)rats.METHODS: Fifty SD rats were randomly divided into control, model, EA sensitized acupoint and EA non-sensitized acupoint groups, with 20 rats in the model group and 10 rats in each of the other 3 groups. The D-IBS model was established by chronic restraint stress and intragastric administration of folium sennae (0.3 g/mL, 10 mL/kg), once daily for 2 weeks, followed by two weeks' restraint stress stimulation. The sensitized acupoints were determined by locating the extravasation points of Evans Blue (EB) dye after tail-intravenous injection, and stimulated with EA (2 mA, 2 Hz) for 30 min, once daily for 7 consecutive days. For rats of the EA non-sensitized acupoint group, bilateral BL 15 were stimulated with the same parameters and same stimulation duration. The rats' bowel mobility was evaluated by Bristol stool scale (BSS), loose stools rate and diarrhea index.RESULTS: After modeling, the BSS, loose stool rate, and diarrhea index were significantly increased in the model group relevant to the control group (P

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11:50

Electroacupuncture pretreatment attenuates acute lung injury in rats after cardiopulmonary bypass. GreenMedInfo

PMID:  Shock. 2017 Nov 7. Epub 2017 Nov 7. PMID: 29117064 Abstract Title:  Electroacupuncture Pretreatment Attenuates Acute Lung Injury Through7 Nicotinic Acetylcholine Receptor-Mediated Inhibition of HMGB1 Release in Rats after Cardiopulmonary Bypass. Abstract:  Acute lung injury is a common complication after cardiopulmonary bypass (CPB).7 nicotinic acetylcholine receptors (7nAChR) and 7nAChR-dependent cholinergic signaling are implicated in suppressing the release of high mobility group box 1 (HMGB1) and reducing the inflammatory response. A previous study has shown the electroacupuncture (EA) pretreatment induces tolerance against lung injury. However, the role of EA in CPB is poorly understood. This study employed EA and a rat model of CPB to determine whether EA was associated with CPB-induced lung injury. Rats were treated with EA at"Zusanli (ST36)"and"Feishu (BL13)"acupoints for 5 days before being subjected to CPB. Two hours post-CPB, samples of blood, bronchoalveolar lavage fluid (BALF) and lung tissues were processed for investigations. Our results showed that the expression of7nAChR in lung tissue was significantly decreased after CPB. EA pretreatment prevented the reduction in the expression of 7nAChR, EA pretreatment reduced lung edema, inhibited inflammatory cytokines release in serum and lung as well as protein concentrations in BALF and HMGB1 release following CPB, and the beneficial effects were attenuated by -BGT. Our study demonstrates that EA pretreatment plays a protective role in CPB-induced ALI, and inhibits HMGB1 release through 7nAChR activation in rats.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.

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11:43

Acupuncture may be effective at relieving chronic knee pain. GreenMedInfo

PMID:  Acupunct Med. 2017 Nov 8. Epub 2017 Nov 8. PMID: 29117967 Abstract Title:  Updated systematic review and meta-analysis of acupuncture for chronic knee pain. Abstract:  OBJECTIVE: To assess the effectiveness and safety of acupuncture for the treatment of chronic knee pain (CKP).METHODS: We searched the MEDLINE, EMBASE, Cochrane CENTERAL, CINAHL and four Chinese medical databases from their inception to June 2017. We included randomised controlled trials of acupuncture as the sole treatment or as an adjunctive treatment for CKP. The primary outcome was pain intensity measured by visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale and 11-point numeric rating scale. Secondary outcome measurements included the 36-Item Short Form Health Survey and adverse events. The quality of all included studies was evaluated using the Cochrane risk-of-bias criteria and the STRICTA (Standards for Reporting Interventions in Controlled Trials of Acupuncture) checklist.RESULTS: Nineteen trials were included in this systematic review. Of these, data from 17 studies were available for analysis. Regarding the effectiveness of acupuncture alone or combined with other treatment, the results of the meta-analysis showed that acupuncture was associated with significantly reduced CKP at 12 weeks on WOMAC pain subscale (mean difference (MD) -1.12, 95%confidence interval (CI) -1.98 to -0.26, I(2)=62%, 3 trials, 608 participants) and VAS (MD -10.56, 95%CI -17.69 to -3.44, I(2)=0%, 2 trials, 145 patients). As for safety, no difference was found between the acupuncture and control groups (risk ratio 1.08, 95%CI 0.54 to 2.17, I(2)=29%).CONCLUSION: From this systematic review, we conclude that acupuncture may be effective at relieving CKP 12 weeks after acupuncture administration, based on the current evidence and our protocol. However, given the heterogeneity and methodological limitations of the included trials, we are currently unable to draw any strong conclusions regarding the effectiveness of acupuncture for chronic knee pain. In addition, we found that acupuncture appears to have a satisfactory safety profile, although further studies with larger numbers of participants are needed to confirm the safety of this technique.STRENGTHS: Systematic review without language restrictions.LIMITATIONS: Only a few high-quality and consistent trials could be included in this review.

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11:31

Acupuncture and conventional medicine for chronic neck pain have similar effectiveness on pain and disability. GreenMedInfo

PMID:  Am J Chin Med. 2017 Nov 9:1-23. Epub 2017 Nov 9. PMID: 29121797 Abstract Title:  Effectiveness of Acupuncture and Electroacupuncture for Chronic Neck Pain: A Systematic Review and Meta-Analysis. Abstract:  The aim of this systematic review was to assess evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture and electroacupuncture in patients with chronic neck pain. We searched nine databases including Chinese, Japanese and Korean databases through 30 July 2016. The participants were adults with chronic neck pain and were treated with acupuncture or electroacupuncture. Eligible trials were those with intervention groups receiving acupuncture and electroacupuncture with or without active control, and control groups receiving other conventional treatments such as physical therapy or medication. Outcomes included pain intensity, disability, quality of life (QoL) and adverse effects. For statistical pooling, the standardized mean difference (SMD) and its 95% confidence interval (CI) were calculated using a fixed-effects model. Sixteen RCTs were selected. The comparison of the sole acupuncture group and the active control group did not come out with a significant difference in pain (SMD 0.24, 95% CI [Formula: see text]0.27-0.75), disability (SMD 0.51, 95% CI [Formula: see text]0.01-1.02), or QoL (SMD [Formula: see text]0.37, 95% CI [Formula: see text]1.09-0.35), showing a similar effectiveness of acupuncture with active control. When acupuncture was added into the control group, the acupuncture add-on group showed significantly higher relief of pain in studies with unclear allocation concealment (SMD [Formula: see text]1.78, 95% CI [Formula: see text]2.08-[Formula: see text]1.48), but did not show significant relief of pain in studies with good allocation concealment (SMD [Formula: see text]0.07, 95% CI [Formula: see text]0.26-0.12). Significant relief of pain was observed when the sole electroacupuncture group was compared to the control group or electroacupuncture was added onto the active control group, but a lot of the results were evaluated to have low level of evidence, making it difficult to draw clear conclusions. In the result reporting adverse effects, no serious outcome of adverse event was confirmed. Acupuncture and conventional medicine for chronic neck pain have similar effectiveness on pain and disability when compared solely between the two of them. When acupuncture was added onto conventional treatment it relieved pain better, and electroacupuncture relieved pain even more. It is difficult to draw conclusion because the included studies have a high risk of bias and imprecision. Therefore better designed large-scale studies are needed in the future.

...

11:19

Acupuncture at HT7 can attenuate anxiety-like behaviour induced by withdrawal from chronic morphine treatment. GreenMedInfo

PMID:  Neurosci Lett. 2017 Nov 7 ;664:38-42. Epub 2017 Nov 7. PMID: 29126776 Abstract Title:  Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use. Abstract:  OBJECTIVES: In the previous studies, it has been demonstrated that acupuncture treatment was effective on the suppression of withdrawal signs as well as self-administration behavior induced by morphine. Based on, the present study has investigated whether acupuncture could attenuate the anxiety-like behavior induced by withdrawal from chronic morphine treatment.MATERIALS & METHODS: Male Sprague-Dawley rats weighing 270-300g were treated saline or morphine hydrochloride (10mg/kg, s.c.) for 2 weeks. Following abstinence of 5days in home cage, rats were subjected to the measurement of anxiety-like behavior in the elevated plus maze. Bicuculline (1mg/kg, i.p.) and SCH 50911 (2mg/kg, i.p.) were used to investigate the possible mechanism of acupuncture effects focusing on the GABA receptors system.RESULTS: Acupuncture at HT7 increased the time spent in open arms significantly. Also, these effects of acupuncture at HT7 were blocked by GABAA receptor antagonist.CONCLUSION: Results of the present study suggest that acupuncture at HT7 can attenuate anxiety-like behavior induced by withdrawal from chronic morphine treatment through the mediation of GABAA receptor system.

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11:14

Acupuncture is effective for cancer-related fatigue management. GreenMedInfo

PMID:  Support Care Cancer. 2017 Nov 11. Epub 2017 Nov 11. PMID: 29128952 Abstract Title:  Effects of acupuncture on cancer-related fatigue: a meta-analysis. Abstract:  PURPOSE: This study was designed to critically evaluate the effect of acupuncture on cancer-related fatigue (CRF).METHODS: Seven databases (Cochrane Library, Embase, Medline, Web of Science, CBM, Wanfang, and CNKI) were systematically reviewed from inception to November 2016 for randomized controlled trials (RCTs). Two reviewers critically and independently assessed the risk of bias using Cochrane Collaboration criteria and extracted correlated data using the designed form. All analyses were performed with Review Manager 5.RESULTS: Ten RCTs, including 1327 patients (acupuncture, 733; control, 594), meeting the inclusion criteria for the meta-analysis were identified. Acupuncture had a marked effect on fatigue in cancer patients, regardless of concurrent anti-cancer treatment, particularly among breast cancer patients. The meta-analysis also indicated that acupuncture could significantly mitigate CRF compared with sham acupuncture or usual care. Acupuncture for 20-30 min/session three times/week for two or three weeks, twice weekly for two weeks and weekly for six weeks, and weekly for six weeks had substantial effects on CRF. Six RCTs reported the occurrence of adverse events, whereas five reported none. The remaining study reported some manageable events, including spot bleeding and bruising.CONCLUSIONS: Acupuncture is effective for CRF management and should be recommended as a beneficial alternative therapy for CRF patients, particularly for breast cancer patients and those currently undergoing anti-cancer treatment.

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10:52

A. hirtifolium might be a candidate for tumor suppression. GreenMedInfo

PMID:  Cytotechnology. 2008 Mar ;56(3):179-85. Epub 2008 Apr 11. PMID: 19002856 Abstract Title:  Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Abstract:  Allium hirtifolim (Persian Shallot) belongs to Allium genus (Alliaceae family). We investigated the in vitro effects of chloroformic extract of A. hirtifolium and its Allicin on the proliferation of HeLa (cervical cancer), MCF7 (human, caucasion, breast, adenocarcinoma) and L929 (mouse, C3H/An, connective) cell lines. Our results showed that components of A. hirtifolium might inhibit proliferation of tumor cell lines. This inhibition in HeLa and MCF-7 cells was dose-dependent. The presence of Allicin was evaluated by TLC method in bulbs and the extract of A. hirtifolium was analyzed by HPLC. MTT test was performed 24, 48 and 72 h after cell culture. A significant decrease in cell lines was observed in HeLa and MCF-7 as compared to L929 cell lines. DNA fragmentation analysis revealed a large number of apoptotic cells in treated HeLa and MCF-7 cell groups, but no effects in L929 cells. Therefore A. hirtifolium might be a candidate for tumor suppression.

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10:36

Isoliquiritigenin may be a promising chemopreventive agent against human uterine cervical cancer. GreenMedInfo

PMID:  Mol Nutr Food Res. 2009 Jul ;53(7):826-35. PMID: 19536869 Abstract Title:  Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. Abstract:  This study is the first to investigate the anticancer effect of isoliquiritigenin (ISL) in human cervical carcinoma HeLa cells. The results reveal that ISL inhibits HeLa cells by blocking cell cycle progression in the G2/M phase and inducing apoptosis. Blockade of cell cycle is associated with increased activation of ataxia telangiectasia-mutated (ATM). Activation of ATM by ISL phosphorylated p53 at Serine15, resulting in increased stability of p53 by decreasing p53 and murine double minute-2 (MDM2) interaction. In addition, ISL-mediated G2/M phase arrest was also associated with decreases in the amounts of cyclin B, cyclin A, cdc2, and cdc25C, and increases in the phosphorylation of Chk2, cdc25C, and cdc2. The specific ATM inhibitor caffeine significantly decreased ISL-mediated G2/M arrest by inhibiting the phosphorylation of p53 (Serine15) and Chk2. ISL induced apoptotic cell death is associated with changes in the expression of Bax and Bak, decreasing levels of Bcl-2 and Bcl-X(L), and subsequently triggering mitochondrial apoptotic pathway. In addition, pretreatment of cells with caspase-9 inhibitor blocked ISL-induced apoptosis, indicating that caspase-9 activation is involved in ISL-mediated HeLa cell apoptosis. These findings suggest that ISL may be a promising chemopreventive agent against human uterine cervical cancer.

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10:25

Homeland Security to Release Chemicals into the Air to Simulate a Biological Terror Attack Natural Blaze

By Jay Syrmopoulos

A planned simulation of a chemical and biological attack has people questioning the impact of the drill on human and environmental health.

Newkirk, OK The Department of Homeland Security plans to conduct chemical and biological testing near the border between Kansas and Oklahoma in January and February, and again in June and July, to determine how much protection people would receive from being inside a house or an apartment in the event of a biological terrorist attack, according to a statement on the Homeland Security website.

The DHS press release notes:

The study is part of the Departments ongoing commitment to preparedness and the shared responsibility of protecting the nations critical infrastructure. The purpose of this study is to gather data that enhances our predictive capabilities in the event of a biological agent attack.  Specifically, this work will help in predicting the extent to which an intentional release of a biological agent may penetrate single family and multi-family structures. These tests will release inert chemicals and biological materials that will be used to measure the amount of material that penetrates the buildings under varied conditions.

   SEE: Australia Thunderstorm Asthma Symptoms Persist: Looks Like Biowarfar...

10:23

Anticancer and anti-inflammatory activities of shallot extract. GreenMedInfo

PMID:  Arch Med Sci. 2011 Feb ;7(1):38-44. Epub 2011 Mar 8. PMID: 22291731 Abstract Title:  Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract. Abstract:  INTRODUCTION: Alliumplants are an important part of the diet of many populations and there is a long-held belief in their health-enhancing properties such as cancer prevention. In this study, the anticancer and anti-inflammatory activities of the aqueous extract of the Allium ascalonicum bulbs have been studied.MATERIAL AND METHODS: The antiproliferative and anti-growth activity of the aqueous extract of A. ascalonicum was examined in vitro on different tumor cell lines. Furthermore, the acetic acid-induced vascular permeability as an in vivo assay was used for studying anti-inflammatory activity of the extract.RESULTS: The aqueous extract of A. ascalonicum had the most anti-growth activity on the cancer cell lines; Jurkat and K562 against Wehi 164 with lower cytotoxic preference. The extract also showed much less cytotoxicity against the normal cell (HUVEC) line and significant anti-inflammatory activity in vivo.CONCLUSIONS: It is of interest that the extract of this plant has shown much less cytotoxicity against the normal cell line, and, if this also occurs in vivo, the use of this plant clinically for the treatment of cancer patients would have some scientific support. The results of these assays indicated that A. ascalonicum can be a candidate for prevention and treatment of many diseases related to inflammation and malignancy.

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10:11

Black Seed Reverses Liver Disease new research findings two

Black Seed Reverses Liver Disease

Posted on: Monday, November 13th 2017 at 2:45 pm
This article is copyrighted by GreenMedInfo LLC, 2017

A new study on a widely revered herbal medicine has produced a potential breakthrough in treating a condition that is a warning sign of serious disease risks. This common health problem affects as many as 90 million Americans, most of whom dont even know they are in danger.
Its common knowledge that our liver is the organ that pays the price if we consume too much alcohol. What is less well known is the vital role the liver plays in the regulation of fat in our bodies. Like a central processing hub, the liver removes fat from the bloodstream, from both the food we eat, and as fat is released from other tissues. The liver exports the fat to other parts of the body where it is either burned for fuel or stored for later. When liver metabolism is distorted, as with non-alcoholic fatty liver disease (NAFLD), also called isolated fatty liver (IFL), this balance is not properly regulated, causing fat to accumulate to dangerous levels in the organ.
What alarms health researchers about fatty liver disease is its prevalence among U.S. population -up to 25% of Americans are affected, but most dont know it- and IFLs canary in a coalmine effect of signaling deeper problems on the horizon, such as heart disease, diabetes, and liver cancer. Another cause for concern is the lack of effective drug treatments. Due to the metabolic derangements caused by many pharmaceuticals, several drugs have been found to cause liver disease, such as corticosteroids, and certain cancer and arthritis medications.
Nature is proving once again to be the best cure for what ails us. Nigella sativa, aka black seed, was the subject of a recently released study that sought to determine if the tiny seed with potent historical value could help treat IFL, a condition researchers called the most common cause of progressive liver disorders worldwide. Published in March 2017 in the Journal of Ayub Medical College Abbottabad-Pakistan, ...

10:04

Antioxidant micronutrients in the extract of Persian shallot may rehabilitate liver damages caused by free radicals in diabetes mellitus. GreenMedInfo

PMID:  J Basic Clin Physiol Pharmacol. 2012 ;23(2):83-7. PMID: 23104823 Abstract Title:  Hepatoprotective effects of hydroalcoholic extract of Allium hirtifolium (Persian shallot) in diabetic rats. Abstract:  BACKGROUND: The prevalence of diabetes mellitus (DM) is dramatically increasing worldwide. Prospective studies have reported that high levels of hepatic enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) are associated with later development of diabetes. The aim of the present study was to examine the effect of hydroalcoholic extract of Allium hirtifolium (Persian shallot) on the level of liver enzymes in streptozotocin (STZ)-induced diabetic rats.METHODS: Thirty-two male rats were divided into four groups of eight. The diabetic groups received 100 and 300 mg/kg Persian shallot extract, the diabetic control and non-diabetic control groups received 0.9% saline for 30 days. At the end of the experimental period, fasting blood samples were collected, and enzymes levels were measured.RESULTS: Our findings showed that hydroalcoholic extract of Persian shallot can significantly decrease serum levels of liver enzymes (AST, ALT, ALP and LDH) in treated groups in a dose-dependent fashion (p

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09:56

These findings may help to rationalize the wide use of Persian shallot for the treatment of inflammatory disorders. GreenMedInfo

PMID:  J Ethnopharmacol. 2014 May 28 ;154(1):176-82. Epub 2014 Apr 8. PMID: 24721027 Abstract Title:  Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum). Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione and four related sulfur-containing pyridine N-oxides which are prominent constituents of Allium stipitatum were tested.METHODS: The antiinflammatory activity was tested by the ability of the compounds to inhibit cyclooxygenase (COX-1 and COX-2), whereas the neurological activities were evaluated by assessing the compounds ability to inhibit monoamine oxidase-A (MAO-A) and acetylcholinesterase (AChE). The compounds affinity for the serotonin transport protein (SERT) and the GABAA-benzodiazepine receptor were also investigated.RESULTS: 2-[(Methylthio)methyldithio]pyridine N-oxide showed very high antiinflammatory effects which are comparable with those of common pharmaceuticals (IC of 7.8 and 15.4 M for COX-1 and COX-2, respectively). On the other hand, neurological activities of the compounds were rather modest. Some compounds moderately inhibited AChE (IC of 104-1041 M) and MAO-A (IC of 98-241 M) and exhibited an affinity for the SERT and GABAA-benzodiazepine receptor.CONCLUSIONS: Our findings may help to rationalize the wide use of Persian shallot for the treatment of inflammatory disorders.

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09:43

Shallomin is a useful natural remedy in preventing the progression and treatment of cold sores. GreenMedInfo

PMID:  Jundishapur J Nat Pharm Prod. 2014 Aug ;9(3):e17372. Epub 2014 Aug 1. PMID: 25237646 Abstract Title:  Shallominthe active antimicrobial constituent of persian shallot in treatment of oral herpes: a double-blind randomized clinical trial. Abstract:  BACKGROUND: Previous studies showed that shallomin, the active antimicrobial constituent of Persian shallot, has a wide range of antibacterial and antifungal properties.OBJECTIVES: The objective of this randomized clinical trial was to evaluate the effectiveness of topical shallomin alcoholic solution in treatment of cold sore.PATIENTS AND METHODS: A total of 60 volunteers who met the inclusion criteria were randomly allocated to two equal groups to hourly apply topical of either 0.5% shallomin alcoholic solution or placebo within the first 24 hours of developing cold sores. All the cases were reassessed at six-hour intervals.RESULTS: The cold sores were cleared within six hours among 30% of cases who received shallomin solution and the remaining of the cases in this group were cleared between 6six to 24 hours of application. In the placebo group, clearance of the sores occurred in four cases between 48 to 72 hours and the remaining of cases were cleared after 72 hours.CONCLUSIONS: The results of this study demonstrated that shallomin is a useful natural remedy in preventing the progression and treatment of cold sores and can significantly reduce the duration of ulceration.

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09:22

Syracuse University mumps outbreak bad anti-vaccine math Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Partially because Im an alumnus, and partially because I watch new reports about infectious disease outbreaks all over the world, Ive been following the recent Syracuse University mumps outbreak. As of 13 November 2017, Syracuse University (SU) Health Services has reported 41 confirmed cases and 78 probable cases of the mumps on the SU campus.

Skeptical Raptor

09:21

Will Everyone in the U.S. Soon Need Government Approval to be Parents and Keep Their Children? Health Impact News

Male doctor in early forties comforting scared five year old patient

In the U.S. today, if you disagree with a doctor regarding the healthcare of your child, you risk losing custody of your child for medical neglect which often simply means you wanted a second opinion. Parental rights are seen as non-existent.

by Terri LaPoint
Health Impact News

Children belong to their parents.

Such a concept is foundational to every culture throughout all of human history. The family is the core group of any society. The need of the child for his or her own parents is a need that impacts the child on every level: biologically, psychologically, emotionally, spiritually, developmentally, and culturally.

In most circles, the truth of the above statements is accepted as common knowledge.

However, there are some who do not hold to these most cherished values of family and kinship. Unfortunately, some of these people are radicals and extremists who hold positions of great influence over public policy, which translates into very real problems for families.

In a recent article presented by Health Impact News,  Richard WexlerExecutive Director of the National Coalition for Child Protection Reform, wrote of some radical views of the family by Elizabeth Bartholet, who is a Professor of Family Law at Harvard Law School:

Bartholets ideas are so extreme that they include requiring every family with a young child to open itself to mandatory government surveillance. (Thats not an exaggeration. Theres a summary of her views in the section of this post to the NCCPR Child Welfare Blog called Harvards resident extremist  and the details are in her own book, Nobodys Children, pp. 170, 171).

See:

The REAL Foster Care Housing Crisis: Too Many Foster Children, NOT...

09:19

Shallot extract has potent in vitro anti-angiogenic activity. GreenMedInfo

PMID:  Int J Mol Cell Med. 2014 ;3(4):237-45. PMID: 25635250 Abstract Title:  A Highly Pure Sub-Fraction of Shallot Extract With Potent in vitro Anti-Angiogenic Activity. Abstract:  Our previous studies showed that various extracts of Persian shallot (Allium hirtifolium) have anti- angiogenic effects. This study has been undertaken to isolate and identify the major effective anti- angiogeneic sub-fraction of shallot. After preparation of the 50% hydroalcoholic extract of shallot bulbs, the extract was successively fractionated into n- hexane, ethyl acetate, n- butanol and aqueous fractions. Anti-angiogenesis activity of fractions was examined by in vitro angiogenesis assay. The ethyl acetate fraction which had the most anti-angiogenesis activity was further fractionated to four sub- fractions by thin layer chromatography (TLC), silica gel column chromatography and then analyzed by High Performance TLC (HPTLC) with ethyl acetate-methanol- water as the solvent system. Our results showed that one of the four sub- fractions, as the major band in HPTLC, had the most anti- angiogenic activity. Purification and characterization of the major anti- angiogenic compound/compounds of shallot's extract may constitute one means by which diets rich in shallot confer protection against cancer and finally introduce new agents with pharmacological activities in shallot as a potential candidate in cancer therapy.

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08:37

Isoliquiritigenin may be a potential therapeutic agent for the prevention and treatment of mesangial fibrosis and glomerulosclerosis. GreenMedInfo

PMID:  J Agric Food Chem. 2010 Mar 10 ;58(5):3205-12. PMID: 20146476 Abstract Title:  Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation. Abstract:  Diabetic nephropathy characterized as mesangial fibrosis and glomerulosclerosis results in renal failure and end-stage renal diseases. Enhanced expression and secretion of connective tissue growth factor (CTGF) play an important role in the expansion of glomerular mesangial matrix mostly composed of type IV collagen. Isoliquiritigenin can prevent various renal injuries via its anti-inflammatory action. However, the effect of isoliquiritigenin on diabetic nephropathy has never been explored. The present study was to investigate whether nontoxic isoliquiritigenin inhibited high glucose (HG)-induced mesangial fibrosis by retarding formation of type IV collagen as well as CTGF in human mesangial cells (HRMC). Serum starved cells were cultured in media containing 5.5 mM glucose plus 27.5 mM mannitol as an osmotic control or 33 mM glucose for 3 days with and without 1-20 microM isoliquiritigenin. Exposure of cells to HG caused marked increases in collagen secretion and CTGF expression, which was dose-dependently reversed by isoliquiritigenin at the transcriptional levels. Additionally, isoliquiritigenin boosted HG-plummeted type matrix metalloproteinase-1 (MT-1 MMP) expression and dampened HG-elevated tissue inhibitor of MMP-2 (TIMP-2) expression, facilitating the degradation of mesangial matrix. Isoliquiritigenin inhibited HG-upregulated CTGF and TIMP-2 expression via disturbing TGF-beta1 signaling in HRMC, as evidenced by TGF-beta receptor I kinase (TGF-beta RI) inhibitor. HG-activated SMAD2 through autocrine TGF-beta signaling was repealed by>or =10 microM isoliquiritigenin. HG induced SMAD4 expression of HRMC and obliterated antagonistic SMAD7, whereas isoliquiritigenin suppressed induction of TGF-beta RII and TGF-beta RI with blunting their downstream SMAD signaling. The results demonstrate that the bioactive isoliquiritigenin in licorice diminished mesangial matrix accumulation in response to ambient HG through retarding TGF-beta1-SMAD signaling transduction. Therefore, isoliquiritigenin may be a potential therapeutic agent for the prevention and treatment of mesangial fibrosis and glomerulosclerosis leading to diabetic nephropathy due to longstanding diabetes mellitus.

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08:25

Isoliquiritigenin selectively inhibits the proliferation of prostate cancer cells. GreenMedInfo

PMID:  Clin Exp Pharmacol Physiol. 2010 Aug ;37(8):841-7. Epub 2010 Apr 26. PMID: 20456427 Abstract Title:  Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. Abstract:  1. Isoliquiritigenin (ISL) is a simple chalcone-type flavonoid derived from liquorice compounds. It has been reported to have anti-oxidative and antitumour activities. The aim of the present study was to investigate the antitumour effect of ISL on prostate cancer cells and to explore the possible signalling mechanisms involved. 2. Cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The fluorescent probe 2',7'-dichlorofluorescein diacetate (H(2)DCF-DA) was used to measure intracellular levels of reactive oxygen species (ROS). Mitochondrial membrane potential (Psi(m)) was measured using the mitochondrial probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazolylcarbocyanine iodide (JC-1). 3. Isoliquiritigenin treatment (10-100 micromol/L for 24 h) markedly inhibited the proliferation of both C4-2 and LNCaP prostate cancer cells in a dose-dependent manner. Intriguingly, ISL treatment (10-100 micromol/L for 24 h) had no effect on the viability of IEC-6 normal epithelial cells. Treatment of C4-2 and IEC-6 cells with 87.0 micromol/L ISL significantly decreased ROS levels and the Psi(m) of C4-2 cells, but had no effect on either parameter in IEC-6 cells. Furthermore, AMP-activated protein kinase (AMPK) and extracellular-signal regulated kinase (ERK) levels were three to fourfold higher in IEC-6 cells than in C4-2 cells (P

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08:18

Isoliquiritigenin may be a valuable adjunct for cancer therapy to treat otherwise drug-resistant tumours. GreenMedInfo

PMID:  Naunyn Schmiedebergs Arch Pharmacol. 2010 Sep ;382(3):221-34. Epub 2010 Jul 29. PMID: 20668838 Abstract Title:  Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics. Abstract:  The development of drug resistance in cancer cells necessitates the identification of novel agents with improved activity towards cancer cells. In the present investigation, we compared the cytotoxicity of the chalcone flavonoide, isoliquiritigenin (ISL), with that of doxorubicin (DOX) and methotrexate (MTX) in five T cell acute lymphoblastic leukaemia (T-ALL) cell lines (Jurkat, J-Jhan, J16, HUT78 and Karpas 45). To gain insight into the molecular mechanisms which determine the response of T-ALL cells towards ISL, DOX and MTX, we applied array-based matrix comparative genomic hybridisation and microarray-based mRNA expression profiling and compared the genomic and transcriptomic profiles of the cell lines with their 50% inhibition (IC(50)) values for these three drugs. The IC(50) values for ISL did not correlate with those for DOX or MTX, indicating that ISL was still active in DOX- or MTX-unresponsive cell lines. Likewise, the genomic imbalances of chromosomal clones and mRNA expression profile significantly correlating with IC(50) values for ISL were different from thoses correlating with IC(50) values for DOX and MTX. In conclusion, ISL represents a cytotoxic natural product with activity towards T-ALL cell lines. There was no cross-resistance between ISL and DOX or MTX, and the genomic and transcriptomic profiles pointed to different molecular modes of action of ISL as compared to DOX and MTX, indicating that ISL may be a valuable adjunct for cancer therapy to treat otherwise drug-resistant tumours.

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08:14

Definition of High Blood Pressiure just changed to trick HALF of US Adults new research findings two

Pharma drug cartel just changed the definition of high blood pressure to trick HALF of U.S. adults into treatment with high-profit prescription drugs










(Natural News) The pharma drug cartel has become not just a total joke to medicine and science, but increasingly a threat to the health and safety of the American pe...

08:01

Will Everyone in the U.S. Soon Need Government Approval to be Parents and Keep Their Children? Medical Kidnap

Male doctor in early forties comforting scared five year old patient

In the U.S. today, if you disagree with a doctor regarding the healthcare of your child, you risk losing custody of your child for medical neglect which often simply means you wanted a second opinion. Parental rights are seen as non-existent.

by Terri LaPoint
Health Impact News

Children belong to their parents.

Such a concept is foundational to every culture throughout all of human history. The family is the core group of any society. The need of the child for his or her own parents is a need that impacts the child on every level: biologically, psychologically, emotionally, spiritually, developmentally, and culturally.

In most circles, the truth of the above statements is accepted as common knowledge.

However, there are some who do not hold to these most cherished values of family and kinship. Unfortunately, some of these people are radicals and extremists who hold positions of great influence over public policy, which translates into very real problems for families.

In a recent article presented by Health Impact News,  Richard WexlerExecutive Director of the National Coalition for Child Protection Reform, wrote of some radical views of the family by Elizabeth Bartholet, who is a Professor of Family Law at Harvard Law School:

Bartholets ideas are so extreme that they include requiring every family with a young child to open itself to mandatory government surveillance. (Thats not an exaggeration. Theres a summary of her views in the section of this post to the NCCPR Child Welfare Blog called Harvards resident extremist  and the details are in her own book, Nobodys Children, pp. 170, 171).

See:

...

07:49

FDA Tries Again To Ban Natural Pain Herb Doom and Bloom (TM)

FDA Tries Again To Ban Kratom Last year, I wrote about the Food and Drug Administrations campaign to ban the Asian herb Kratom, a non-opiate option for those with chronic pain, anxiety, and drug dependency issues. As someone interested in medical strategies for disaster or remote settings, I was considering the herb as an option in circumstances when modern medicine isnt available. The FDA, however, set a date for late 2016 to rule Kratom a Schedule I drug (the same

[... Continue Reading]

07:46

Isoliquiritigenin is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2011 Oct 7 ;413(4):637-42. Epub 2011 Sep 14. PMID: 21945440 Abstract Title:  Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Abstract:  Isoliquiritigenin (ILTG) is a chalcone compound and has valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer, and antiallergic activities. Recently, the anxiolytic effect of ILTG has been reported; however, its action mechanism and hypnotic activity have not yet been demonstrated. Therefore, we investigated the hypnotic effect and action mechanism of ILTG. ILTG significantly potentiated the pentobarbital-induced sleep in mice at doses of 25 and 50mg/kg. The hypnotic activity of ILTG was fully inhibited by flumazenil (FLU), a specific gamma-aminobutyric acid type A (GABA(A))-benzodiazepine (BZD) receptor antagonist. The binding affinity of ILTG was 0.453M and was found to be higher than that of the reference compound, diazepam (DZP, 0.012 M). ILTG (10(-5)M) potentiated GABA-evoked currents to 151% of the control level on isolated dorsal raphe neurons. ILTG has 65 times higher affinity for GABA(A)-BZD receptors than DZP, and the dissociation constant for ILTG was 4.0 10(-10)M. The effect of ILTG on GABA currents was blocked by 10(-7)M FLU and ZK-93426. These results suggest that ILTG produces hypnotic effects by positive allosteric modulation of GABA(A)-BZD receptors.

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07:32

Isoliquiritigenin has analgesic and uterine relaxant effects. GreenMedInfo

PMID:  Phytother Res. 2012 Sep ;26(9):1410-7. Epub 2012 Mar 3. PMID: 22389128 Abstract Title:  Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. Abstract:  Shaoyao-gancao-tang, a Chinese medicinal formula consisting of peony and licorice has been used for the treatment of dysmenorrhea for thousands of years. The purpose of the present study was to demonstrate the analgesic and uterine relaxant effects of isoliquiritigenin (ISL), a flavonoid isolated from the roots of Glycyrrhiza glabra (a type of licorice). In vitro, isoliquiritigenin caused concentration-dependent inhibition of spontaneous contraction of isolated rat uterus and the contraction induced by various types of stimulants, such as acetylcholine (Ach, 10 mM), KCl (40 mM) and oxytocin (1 mU/mL). The uterine contractile response to cumulative concentrations of CaCl was blocked by 0.1 and 1 mM of isoliquiritigenin. The isoliquiritigenin-induced relaxation was partly inhibited by the nitric oxide synthase (NOS) inhibitor Nv-nitro-L-arginine methylester (L-NAME, 100 mM) and the COX-1/COX-2 inhibitor indomethacin (10mM). In vivo, isoliquiritigenin could causea significant reduction in the acetic acid-induced writhing response and hot-plate test at the high dose. These results indicate that isoliquiritigenin, a flavonoid isolated from the roots of Glycyrrhiza glabra, not only has a spasmolytic effect on uterine contraction, which is in relation to Cachannels, NOS and COX, but also an effective activity in reducing pain.

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07:21

Over 1 Million Call on DOJ to Block Bayer-Monsanto Merger Natural Blaze

bayer monsanto merger

New reports reveal devastating impacts on consumers and farmers.

WASHINGTON Over 1 million petition signatures were delivered today by farming, consumer and environmental groups  to the U.S. Department of Justice calling on the department to block the proposed merger of Bayer (BAYN) and Monsanto (MON). The signatures were delivered as two new reports revealed irreversible impacts from the merger on consumers and farmers.

Tuesday, Friends of the Earth, SumOfUs and the Open Markets Institute released an analysis, Bayer-Monsanto Merger: Big Data, Big Agriculture, Big Problems, which  explores the implications of a combined Big Data, chemical and seed platform owned by Bayer and Monsanto and how it may impact competition and farmer choice. The release of the analysis coincides with a hearing Tuesday on technology in agriculture and data-driven farming in the U.S. Senate Committee on Commerce, Science, & Transportation.

...

07:18

Farmland is Renewing Detroit. Behold the Benefits of Urban Agriculture REALfarmacy.com

Source: Farmland is Renewing Detroit. Behold the Benefits of Urban Agriculture For more content like this visit REALfarmacy.com.

The key to many modern problems is as simple as increasing the prevalence of small-scale organic gardening. Urban agriculture is a sure way to turn a food desert into an oasis of nutrition, sustenance, and sustainability. Not to mention that gardening has been scientifically proven to be extremely therapeutic, just imagine the extra cultural benefits []

Source: Farmland is Renewing Detroit. Behold the Benefits of Urban Agriculture Learn more at REALfarmacy.com - Healthy News and Information.

07:15

Isoliquiritigenin can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process. GreenMedInfo

PMID:  Biosci Biotechnol Biochem. 2012 ;76(3):536-43. PMID: 22451397 Abstract Title:  Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons. Abstract:  Licorice (Glycyrrhiza uralensis) is a medicinal herb containing various bioactive components implicated in antioxidative, anti-inflammatory, antiviral, and neuroprotective effects, but the effects of licorice against Parkinson's disease (PD)-related dopaminergic cell death have not been studied. In this study, we investigated the protective effects of isoliquiritigenin (ISL) isolated from Glycyrrhiza uralensis on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in a dopaminergic cell line, SN4741. ISL (1M) significantly attenuated 6-OHDA (50 M)-induced reactive oxygen species (ROS) and nitric oxide (NO) generation and apoptotic cell death. ISL pretreatment effectively suppressed 6-OHDA-mediated upregulation of Bax, p-c-Jun N-terminal kinase (JNK), p-p38 mitogen-activated protein (MAP) kinase, cytochrome c release, and caspase 3 activation. In addition, ISL significantly attenuated 6-OHDA-induced Bcl-2, brain-derived neurotrophic factor (BDNF), and mitochondrial membrane potential (MMP) reduction. Pharmacological inhibitors of the phosphatidylinositol 3-kinase (PI3K)-Akt/protein kinase B (PKB) pathway reversed ISL-mediated neuroprotection against 6-OHDA toxicity in SN4741 cells. These results provide the first evidence that ISL can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process.

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07:01

Action Alert! Senate Should Reject Alex Azar AGE OF AUTISM

Thank you to Autism Action Network for this action alert. You may be able to help stop this appointment by sharing your concerns with your Senator. The action alert below includes a link, and letter you can use through the...

06:57

Glycyrrhizae radix may have a possible therapeutic role for preventing the progression of neurodegenerative disease such as Alzheimer's disease. GreenMedInfo

PMID:  Arch Pharm Res. 2012 May ;35(5):897-904. Epub 2012 May 29. PMID: 22644857 Abstract Title:  Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on A(25-35)-induced neurotoxicity in cultured rat cortical neurons. Abstract:  This study investigated an ethanol extract from Glycyrrhizae radix (GR), the root of Glycyrrhiza uralensis (Leguminosae), for possible neuroprotective effects on neurotoxicity induced by amyloid protein (A) (25-35) in cultured rat cortical neurons. Exposure of cultured cortical neurons to 10 M A (25-35) for 36 h induced neuronal apoptotic death. GR (10-50 g/mL) prevented the A (25-35)-induced neuronal apoptotic death, as assessed by a MTT assay and Hoechst 33342 staining. Furthermore, GR decreased the expression of Bax and active caspase-3, proapoptotic proteins, and increased Bcl-2, an antiapoptotic protein. GR also significantly inhibited A (25-35)-induced elevation of the intracellular Ca(2+) concentration ([Ca(2+)](i)) and generation of reactive oxygen species (ROS)measured by fluorescent dyes. Isoliquiritigenin (1-20 M), isolated from GR as an active component, inhibited A (25-35)-induced neuronal apoptotic death, elevation of [Ca(2+)](i), ROS generation, and the change of apoptosis-associated proteins in cultured cortical neurons, suggesting that the neuroprotective effect of GR may be, at least partly, attributable to this compound. These results suggest that GR and isoliquiritigenin prevent A (25-35)-induced neuronal apoptotic death by interfering with the increases of [Ca(2+)](i) and ROS, and GR may have a possible therapeutic role for preventing the progression of neurodegenerative disease such as Alzheimer's disease.

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06:56

Childrens book review Judah Maccabee Goes to the Doctor for vaccine Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Judah Maccabee Goes to the Doctor is a recently published childrens book written by Ann D. Koffsky  and illustrated by Talitha Shipman. Its not aimed to introduce children to the science of vaccines, or to convince the heistant. It is, however, incredibly useful to parents who intend to vaccinate and want to help young children

Skeptical Raptor

06:56

Backstage, front row experience of the controversial US panel on energy at COP23 Thoughtscapism

I would never have guessed a panel discussion on energy could have been as intense as this one. I went from thinking I would not even be able to see it, to being lead to the room following the special Continue reading

06:49

HCG Found in WHO Tetanus Vaccine in Kenya Raises Concern in the Developing World AGE OF AUTISM

Thank you to our loyal reader Dr. K.O. for making us aware of this paper. Open Access Library Journal John W. Oller1, Christopher A. Shaw2,3, Lucija Tomljenovic2,3, Stephen K. Karanja4, Wahome Ngare4, Felicia M. Clement5, Jamie Ryan Pillette5 1Communicative Disorders,...

06:42

Corey Feldman Names #2nd Hollywood Pedophile That Molested Him REALfarmacy.com

Source: Corey Feldman Names #2nd Hollywood Pedophile That Molested Him For more content like this visit REALfarmacy.com.

Child actor, Corey Feldman reveals his second sexual abuser from when he was a young star in Hollywood. Watch below:

Source: Corey Feldman Names #2nd Hollywood Pedophile That Molested Him Learn more at REALfarmacy.com - Healthy News and Information.

05:57

Pharma Insider Reveals How the Opioid Crime Network Operates REALfarmacy.com

Source: Pharma Insider Reveals How the Opioid Crime Network Operates For more content like this visit REALfarmacy.com.

by Jon Rappoport Opioid drugs: morphine, hydrocodone, oxycodone, fentanyl, naloxone, Percocet, etc. PBS Frontline (2/23/2016): The opioid epidemic has been called the worst drug crisis in American historywith overdoses from heroin and other opioids now killing more than 27,000 people a year (Note: prescription opioids are now a very significant gateway-drug leading addicts into heroin.) []

Source: Pharma Insider Reveals How the Opioid Crime Network Operates Learn more at REALfarmacy.com - Healthy News and Information.

04:57

Evidence Mounts: Plague Outbreak Is an Engineered Depopulation Bioweapon REALfarmacy.com

Source: Evidence Mounts: Plague Outbreak Is an Engineered Depopulation Bioweapon For more content like this visit REALfarmacy.com.

Thousands of people have been infected and over 143 are now reported dead from the plague outbreak thats now threatening Africa, reports the UK Daily Mail. Health officials are unsure how this years outbreak began, reports the paper. Experts warn the disease spreads quicker in heavily populated areas. Isnt it interesting that just as Prince []

Source: Evidence Mounts: Plague Outbreak Is an Engineered Depopulation Bioweapon Learn more at REALfarmacy.com - Healthy News and Information.

04:52

Yerba Mate Enhances Cellular Energy and Metabolism Natural Blaze

By Joe Battaglia

In South America, Yerba Mate has been grown and taken medicinally for centuries. Researchers have shown that use of the herb over an extended period had significant effects on body weight and weight gain and was associated with lower levels of blood lipids and insulin in obese mice fed a high-fat diet.

Some of the most important antioxidant enzymes in the body are induced by mate. It is rich in polyphenols and displays high antioxidant activity. Its also a cancer killer. Mate tea drinkers experience a significant increase in the activity of an enzyme that promotes HDL (good) cholesterol which prevents fats from oxidizing. Mate is traditionally steeped and served in a hollow calabash gourd (itself called a mate) and drunk through a metal straw called a bombilla. You can also make mate in a standard automatic coffee maker. Just put the mate where you would normally put the coffee grounds.

This new study, which supports the anti-obesity effect of long-term supplementation with yerba mate, and its beneficial effects on related metabolic disorders, is published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Medicinal Food website.

...

04:08

Irreversible Impacts on People and the Environment: More Than One Million Signatures Delivered to Block Proposed Monsanto-Bayer Merger AltHealthWorks.com

bayer monsanto merger

 

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The merger between Monsanto and Bayer, two giants in the chemcial and genetically engineered seed industries, has been in the works for several months now, with everyone from farmers to business analysts weighing in on the possible impacts of such a deal.

But now, the voices of the people are being added to the mix, and in this case on a historic scale: over 1 million petition signatures have just been delivered by farming, consumer and environmental groups to the United States Department of Justice calling on the body to block what could be one of the biggest consolidations of corporate power in the nations history.

A Tight Oligopoly on Steroids

As noted by a release from the grassroots organization Friends of the Earth, the delivering of the signatures coincided with Tuesdays hearing on technology in agriculture and data-driven farming in the U.S. Senate Committee on Commerce, Science & Transportation.

It also included the release of an analysis by FOE, SumOfUs and Open Markets Institute on the merger titled Bayer-Monsanto Merger: Big Data, Big Agriculture, Big Problems exploring the devastating potential impacts of the deal, which they said could lead to irreversible impacts on consumers and farmers.

In addition, the Consumer Federation of America also released a report titled Mega-Mergers in the U.S. Seed and Agrochemical Sector the Political Economy of Tight Oligopolies on Steroids and the Squeeze on Farmers a...

03:43

GMO vaccines Making Siblings of Millions of Children new research findings two

GMO-Vaccines Making Siblings of Millions of Children, Teens and College Students: Who Can They Safely Have Children With In The Future?

All the vaccines for kids are GMO.  The instability that Jeffrey Smith lists for agricultural GMOs all apply to the vaccines.

1.  GMO vaccines genetically engineer - alter the DNA of - anyone receiving them, using the very same method used to genetically engineer seeds.  Children are being genetically engineered.  See:  http://salem-news.com/articles/july172011/murdoch-vaccines-wn.php

2.  The GMO material is patented, just as with seeds.  Who owns children's blood, organs, bones, etc. if they include patented IP?  We know how Monsanto acts about ownership. 

3.  Did you agree to have patented corporate intellectual property inside your child?  No?  Then it's a contract or IP law violation because it wasn't disclosed to you.

4.  The GMO material injected into your child added new DNA strains to your child's DNA - from insect, pigs, monkey, viruses, etc.  For the first time in human history, a new parental line has been added to children's genetic heritage - mother's DNA, father's DNA, insect DNA.  Did you agree to this rape of your child's DNA by strangers, by other species?

5.  Did you agree to having your genetic heritage, 10s or 1000s of years in the making and unique - beyond priceless intellectual property - corrupted in this way?  Were you informed and compensated by the biotech industry in a contract for them to insert their own DNA choices into your child's DNA, your family's genetic heritage?

6.  Did the same GMO-DNA in one vaccine get that injected into other children as well?  Into how many others?  1?  10?  100?  1000?  10,000?  100,000?  A million?  However many children who had the GMO DNA forced into them by injection, are now SIBLINGS (even if only 1/3 siblings  (mother, father, corporate GMO-DNA) of your child by virtue of sharing one parental line.  Were you informed this would be the consequence of the vaccine yo...

03:30

10 Superfood Powders and How They Benefit Your Health Natural Blaze

By Anna Hunt

As a rule of thumb, half of every meal you eat should be made up of nutrient-rich superfoods, such as fruits and vegetables. When you eat a healthy diet over a long term, youre more likely to prevent chronic illness, such as heart disease, obesity, diabetes and cancer. Yet, most people dont eat sufficient amounts of vegetables. Therefore, its smart to supplement your diet in order to benefit your health, and there are plenty of exotic superfood powders that can help you do this.

Theres no denying that the availability of superfood supplements is a good thing. Nevertheless, there are now so many options, it can become overwhelming when deciding which superfood is best for you. Hence, below is a list of some of the more popular superfood powders, with a short description of how they benefit your health.

When choosing a superfood powder, its best to first decide what you want to accomplish (i.e. improve digestion, lower blood pressure, reduce inflammation). Then, pick only two or three superfood powders that will help you meet that goal. Finally, make sure you consume them daily with your juices, smoothies and meals, so you can reap the benefits. Sometimes, taking a capsule supplement or tablet may be the best option. Remember, the effects of taking superfood supplements are gradual and increase over time.

1. Moringa

Moringa is a very potent source of plant-based nutrition. About one tablespoon of moringa powder contains the nutrients of one full serving of vegetables. The plant is rich in iron, potassium and Vitamins A, B6 and C. It also offers 17 times more protein than milk and is packed with essential amino acids.

As a natural detoxifier, moringa purifies and nourishes blood, muscle tissues, bone marrow and fat tissues. In addition, it is a powerful antioxidant. Thus, it helps to fight off free radicals that bring on sickness and disease.

03:29

Ingredient In Cows Milk Primary Causal Trigger of Type 1 Diabetes Natural Blaze

By Maria Andrade

An ingredient in cows milk has now been identified as a type 1 diabetes trigger in those with genetic risk factors, but researchers say they have been frustrated in efforts to make the findings available to the wider public.

The United States is the worlds largest producer of pasteurized cow milk, but oddly enough it is also one of the worlds smallest consumers. The dairy industry thus has a vested interest in eliminating all raw milk suppliers from the market place to enforce and increase per capita consumption of pasteurized milk which is lagging behind most of the world.

Pasteurized milk is perhaps one of the most nutritionally deficient beverages misappropriately labeled as a perfect food. Raw milk enthusiasts have known for a very long time that unpasteurized milk is the ONLY milk worthy of consumption.

Pasteurization destroys enzymes, diminishes vitamin content, denatures fragile milk proteins, destroys vitamins C, B12 and B6, kills beneficial bacteria, promotes pathogens and is associated with allergies, increased tooth decay, colic in infants, growth problems in children, osteoporosis, arthritis, heart disease and cancer.

Seven researchers...

03:17

FDA Approves New Digital Sensor To Ensure Patients With Mental Health Issues Take Their Meds Natural Blaze

By Mac Slavo

The Food and Drug Administration has just approved a new pill with a digital sensor in it. It will ensure that patients who suffer from mental health issues take their medicine when they are told. But privacy concerns have not gone unnoticed.

Regulators in the United States have approved the first pill that can be digitally tracked as it makes its way through the human body. The Abilify MyCite aripiprazole tablets used for treating schizophrenia and manic episodes have an ingestible sensor embedded inside them that records that the medication has been taken. A patch worn by the patient transmits this information to their smartphone.

But many are raising the red flag that this could simply be another form of medical big brother. You may no longer have the right to refuse medications in the very near future.

The Abilify MyCite features a sensor the size of a grain of sand made of silicon, copper, and magnesium. An electrical signal is activated when the sensor comes into contact with stomach acid the sensor then passes through the body naturally. A patch the patient wears on their left rib cage receives the signal several minutes after the pill is ingested. The patch then sends data like the time the pill was taken and the dosage to a smartphone app over Bluetooth. The patch also records activity levels, sleeping patterns, steps taken, activity, and heart rate, and must be replaced every seven d...

03:10

Journal replaces anti-vaccine paper it retracted for missing conflicts, number of errors Retraction Watch

A journal retracted a paper about how conflicts of interest might be influencing research into the link between vaccines and autism because wait for it the authors failed to disclose conflicts of interest. According to the retraction notice, the editors retracted the paper without the authors agreement, because the authors had a host []

The post Journal replaces anti-vaccine paper it retracted for missing conflicts, number of errors appeared first on Retraction Watch.

03:02

Aluminum Dangers new research findings two


Aluminum in Antiperspirants Linked to Cancer and to Brain Damage from Vaccines
by Rishma Parpia and Barbara Loe Fisher
Published November 14, 2017 | Vaccination, Ingredients

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STORY HIGHLIGHTS
  • The use of aluminum in antiperspirants and its link to breast cancer has been report since the 1990s.
  • Due to conflicting studies, public health agencies and stakeholder groups have not ruled out the link between antiperspirants and breast cancer.
  • Aluminum has been known to be a neurotoxin for decades and vaccines contain aluminum adjuvants; however, public health agencies deny aluminum adjuvants cause brain damage and aggressively promote vaccines as safe.
In the 1990s, there was information published linking the use of antiperspirants, underarm shaving and an increased risk of breast cancer.1 The safety concerns were particularly focused on the use of aluminum-based compounds as the active ingredient in antiperspirants.2 Aluminum temporarily plugs the sweat glands blocking the flow of sweat to the surface of the skin, which keeps armpits dry.2
Antiperspirants With Aluminum Must Be Labeled
Public health agencies and medical organizations were quick to deny the link between aluminum containing antiperspirants and cancer and labeled these concerns as rumors and myths. The U.S. Food and Drug Administration (FDA) published an article in a July-August 2005 edition of its consumer magazine, which stated:
According to the National Cancer Institute (NCI), the breast cancer-antiperspirant myth first appeared in the form of an e-mail in the 1990s, and continues to resurface and recirculate about every year or so. The false information suggests that antiperspirants contain harmf...

02:53

Natural Birthcontrol Deodorants dental Care etc Kelly Brogan MD new research findings two


6 Natural Products That Actually Work


Share
Lessen Your Toxic Load
In your quest to find products that support a healthy, conscious lifestyle, do you sometimes feel like you have to compromise between effective and safe? Weve been led to believe that this is the case, through powerful marketing forces that position chemicals as king, and all-natural as the watered-down, over-priced alternative.
Adding to this confusion is the trend of green packaging. Since the FDA does not regulate what goes into health and beauty products, companies cash-in on health-conscious consumers willing to pay more for clean, safe products. Green, leafy logos and words like all natural can conceal the fact that whats inside the bottle is anything but!
The Need for Safe Alternatives
While consulting a list of toxic products to avoid is easy enough, taking the time to read labels and ingredient lists for literally EVERYTHING you buy can be really taxing, not to mention, a total drag! Perhaps this is why people ask me all the time, What do you use?
To help make your adventures in detox a little easier, I am sharing a short list of some of the natural products that I love, and that you can feel good about using. Most importantly, they work great and feel luxurious!
Six Natural Products that Work
1. Deodorant

There are plenty of lovely, all-natural soaps on the market (heck, one bottle of Doc Bronners lasts forever), but have you tried all-natural deodorants? A long-time stress sweat-erI have too many consumer-disappointment experiences to count. (Turns out theres a lot of room for innovation still in the holistic personal fragrance arena). ) Then I found THE ONE and there was no turning back.
For many,  Fat and the Moons decadent deodorant cream is the final stop. Aluminium-fre...

02:23

Edgartown. Letter: Fluoridation should be a townwide decision Fluoride Action Network

I have been reading some of the comments about the fluoridated water issue in Edgartown, and have taken some time to look at the research for myself. There are convincing arguments and good people on both sides.

There are plenty of studies to cite as proof for either opinion. One person cited a recent EPA study that was commissioned on Nov. 23, 2016, and concluded on Feb. 27, 2017. It pains me to say that that study carries little credibility with me personally, given that the current director of the EPA has no desire to protect the environment or the people affected by its decisions.

The point here, however, is not about whether fluoridation is good or not. It is about the procedures of a local government in this case, three people to impose their opinion about what we and our children should ingest on a daily basis, presumably for the rest of our lives. There are obviously some concerns, and some gaps in regards to our knowledge about this. Why the rush? We spent eight years debating the roundabout, after all. Lets put it up for debate, and hear from the people.

We may never know for certain if the risks outweigh the benefits, but right or wrong it is a decision for the people of Edgartown to make, not three officials in a back room.

Donald Keller
Vineyard Haven

*Original letter online at http://www.mvtimes.com/2017/11/15/fluoridation-townwide-decision/

02:13

LIVE HEALTHY TEST FOOD, WATER, ALLERGIES, DENTAL MATERIALS, REMEDIES & MEDICATIONS Lyra Nara Blog

Today everybody lives in a dangerous, polluted environment, full of toxins which penetrate your body by inhalation, ingestion, radiation, transdermally. Toxins are stored in connective tissue and are further transported through the lymphatic and blood stream to different organs, impairing and affecting their functionality. There is a simple method how to determine which are the

01:32

Disinhibited Mad In America

These days, attempting to navigate my way through life feels like swimming through quicksand. As I slowly recover from the aftermath of my run-in with psychiatry, I can only conclude that they are capable of being evil, legal drug pushers. What would compel a so-called doctor to prescribe a new class of drugs (SNRI) at 33.33% over the FDA recommended maximum dose for over a decade and expect no negative consequences?

This doctor was in no uncertain terms gambling with my very sanity. When he began prescribing, he wrote, by his own hand, in my medical record, Imp. No current MDE, or Impression, no current major depressive episode. At the time, I was a 38-year-old man in my prime who truly had it all. What in Dr. Michaels (not his real name) training taught him that it was alright to prescribe an ungodly amount of medication at up to two times the FDA recommended maximum? What protocol was he following that indicated it was okay to treat his patient as a lab rat?

I recently asked Dr. Michael in an email what guidelines he was following that made him think it was a good idea to prescribe the antidepressant Effexor at doses over the FDA maximum for such a long period of time, among other questions. Because he would not respond by email, he sent me a typewritten letter by mail that was obviously coached by a legal professional. In his letter reads the following:

While I prescribed Effexor XR to you in a dose over the FDA suggested maximum, the doses that I prescribed were within the range that psychiatrists in practice use. I was guided by my clinical judgement and consultation with colleagues who specialize in psychopharmacology, who made clear to me that doses over 225 mg per day are acceptable if the trade-off between benefit and side effects is carefully taken into account. (Dr. Michael had me on a dose of 300 mg per day for a decade with doses initially as high as 450 mg per day.)

He had responded with the Everyones doing it defense! I believe that doses of Effexor specifically (and antidepressants in general for that matter), should NEVER be prescribed over the FDA recommended maximum except in the case of severely depressed inpatients as stated in the drug labeling.

When I began punching my wife in the face while I was sleeping, maybe I should have seen the writing on the wall. Maybe this was all my fault. Within the first year of overdosing on Effexor, my whole body started violently shaking and twitching in my sleep. It progressed to swinging my arm and knocking over a lamp on my night table. During the second year was when I began having vivid violent dreams and frequently touching, slapping and on more than one occasion punching my wife in the face while sleeping. You would think this would be an indication to Dr. Michael to lower the dose, but instead he recom...

01:16

Little Girl Savagely Laughed At Over Vaccine Fears Vaxxter

I dont think we have to agree on the issue of vaccines to possess common empathy for our children. And in this case, that common empathy, or even decency, seems to be voided by the...

The post Little Girl Savagely Laughed At Over Vaccine Fears appeared first on Vaxxter.

00:52

Health & Fitness Do You Need to Swim? Natural Blaze

Too much exercise can be as bad for you as not enough. But one factor that some overlook is also the type and variety of exercise that they undertake. Quite often, they become entrenched in their regimes, failing to change or alter anything for fear of losing all that they have worked for.

Here we look at the need for variety, and the benefits that it can have for your health and fitness. Particularly we will look at the sport of swimming and how it can help improve your gains. By the end of the article, a good many of you will be asking the location of their nearest swimming pools.

Benefits

No matter your level of fitness, swimming will always improve the same. Youll feel changes to your muscle tone and strength and you will no doubt become fitter too. Add to this that you will become calmer, and less prone to injury and youll be asking why you havent incorporated swimming before.

Whole

Swimming works the body as a whole, not isolating individual areas as you might in the gym. Changing strokes will also target your muscles in different ways, increasing your gains again. Because water is denser than air, you need undertake less activity for the same results so youre saving time too!

Holistic

As well as a whole body workout, being in one of the local swimming pools will calm your mind and enrichen your soul. Truly it is calming, being supported by the water and away from...

00:29

 FDAs CBER: Asleep at the Switch Again An Ongoing Saga World Mercury Project

By Lyn Redwood, RN, MSN, Executive Director

Background: Peter Patriarca, an FDA employee, admitted back in 1999, in a confidential e-mail obtained through FOIA, that, the greatest point of vulnerability on this issue is that the systematic review of thimerosal in vaccines by the FDA could have been done years ago and on an ongoing basis as the childhood immunization schedule became more complex.  The calculations done by FDA are not complex. Im not sure if there will be an easy way out of the potential perception that the FDA, CDC and immunization policy bodies may have been asleep at the switch re: thimerosal until now. 

Since 1999, an entire generation of children both in the US and internationally has continued to be exposed to thimerosal and it is time for this to stop.  Nobody should be exposed to a known neurotoxin.

The Ongoing Saga: On March 30, 2017, Robert F. Kennedy, Jr., and the World Mercury Project (WMP) team met with the Director of the FDAs Center for Biologics Evaluation and Research (CBER) Dr. Peter Marks, M.D., Ph.D. and his colleagues to discuss the agencys ongoing refusal to ban thimerosal, a mercury-based preservative, from vaccines in the United States. CBER is the division of the FDA responsible for approving and monitoring the safety of all biological products, including vaccines, allergenic products, blood and blood products, and cellular, tissue, and gene therapies.

At the meeting, we presented a large amount of research showing the toxicity of thimerosal in humans, animals and cellular models, including at levels similar to those resulting from vaccine exposures.  We expressed our alarm regarding the total lack of adequate safety testing of thimerosal prior to licensure, especially given its current use in vaccines approved for infants and pregnant women and its worldwide use in millions of vaccines given to children, particularly in developing countries.  Dr. Marks promised to look over the studies and seriously consider our concerns.

After many months of back and forth emails, Dr. Marks sent a letter to us on July 11th that didnt even look like he was in the same meeting. World Mercury Project was dismayed by CBERs apparent unwillingness to seriously review the large archive of published science suggesting that using thimerosal is poisoning a generation of...

00:03

Placebo Myths Debunked Science-Based Medicine

Placebo treatments are often sold as magical mind-over-matter healing effects, but they are mostly just illusions and non-specific effects.

00:00

Caught Our Notice: Oops paper included proofreaders query Retraction Watch

Title: Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases What Caught Our Attention: Everyone makes mistakes but some are more amusing than others. In one recent correction, the publisher (Wiley) admitted to including a proofreaders query in the published manuscript. But didnt say what the query was. We looked around, and think we found the added []

The post Caught Our Notice: Oops paper included proofreaders query appeared first on Retraction Watch.

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Wednesday, 15 November

22:14

Trump Drains the Swamp to Make Room for More Pharma Gold AGE OF AUTISM

President Trump promised to "drain the swamp" during his campaign. His hard talk about pharmaceutical influence on our lives was a strong pull for many within the autism community from conservatives, to moderates to staunch liberals. Many held their noses...

22:11

Dr. Catharine Willis gets full term on Arab Water Board Fluoride Action Network

Three board appointments were made unanimously by the Arab City Council Monday night.

Sid Tidmore was reappointed to the personnel grievance board. George Pollock, who filled out a partial term, was reappointed to the library board, and Dr. Catherine Willis was re-appointed to the Arab Water Works board.

Willis completed the term of Rodney Hyatt, who resigned after moving out of the city and the term was expiring.

Ive served a year and learned a lot, she told the council.

Willis was first appointed to the board during the fluoride debate.

The board had taken fluoride out of the local water supply, and the city had sued to put it back in.

The board eventually won the lawsuit, and fluoride has been out of the citys water supply for more than a year.

Also, Mayor Bob Joslin told the council he had appointed Thomas Shelton to the planning board.

*Original article online at http://www.thearabtribune.com/news/dr-catharine-willis-gets-full-term-on-arab-water-board/article_2258e220-c966-11e7-a4a6-a37e7e803521.html

22:03

Former Eli Lilly Executive is Trumps Choice for Health Secretary Mad In America

From The New York Times: President Trump has nominated Alex M. Azar II, a former president of the American division of Eli Lilly, to be secretary of health and human services, which has responsibility for regulating the pharmaceutical industry.

Mr. Trumps choice of Mr. Azar continues a pattern in which the president has put former industry officials in charge of regulating their former colleagues. At the Department of Health and Human Services, it would fall to Mr. Azar to follow through on the presidents threats to confront drug prices, many of which are manufactured by Mr. Azars former company.

Eli Lilly, where Mr. Azar worked for almost a decade, is one of three manufacturers of insulin whose prices have skyrocketed in recent years. The price increases by the three drug makers Lilly, Novo Nordisk and Sanofi have happened in near lock step and prompted outcries from patient groups. This year, a lawsuit filed by patients accused the companies of fixing prices.

Article

22:02

Americas Opioid Crisis Proves the Limits of Capitalism Mad In America

In this piece for RT, Slavoj iek discusses the impact of capitalism on Americas opioid crisis, exploring the factors that have driven people to use drugs to escape reality.

Capitalism is the first socio-economic order which de-totalizes meaning: it is not global at the level of meaning. There is, after all, no global-capitalist worldview, and no capitalist civilization proper: In fact, the fundamental lesson of globalization is precisely that capitalism can accommodate itself to all civilizations, from Christian to Hindu or Buddhist, from West to East. Capitalisms global dimension can only be formulated at the level of truth-without-meaning, as the reality of the global market mechanism.

This, then, is what makes millions seek refuge in our opiums: not just new poverty and lack of prospect but the unbearable superego pressure in its two aspects the pressure to succeed professionally and the pressure to enjoy life fully in all its intensity. Perhaps, this second aspect is even more unsettling: what remains of our life when our retreat into private pleasure itself becomes the stuff of brutal injunction?

22:01

FDA Approves Pill That Digitally Tracks if Patients Have Ingested it Mad In America

The FDA has approved Abilify MyCite, a pill with a sensor that digitally tracks whether patients have taken their medication.

The system works by sending a message from the pills sensor to a wearable patch. The patch transmits the information to a mobile application so that patients can track the ingestion of the medication on their smart phone. Patients can also permit their caregivers and physician to access the information through a web-based portal.

FDA Press Release 

22:00

New Traction for Art Therapy as a Treatment for Depression Mad In America

Art therapy in Heisa Island Aswan (Photo Credit: Flickr)

17:00

Pesticides Implicated in Infertility Articles

By Dr. Mercola

Human fertility is declining, and recent studies suggest conventional food may be a significant contributor to this disturbing trend, seen in both men and women. Pesticides have repeatedly been implicated in worsening fertility, and one of the most recent studies adds further support to this hypothesis.

The study,1,2 published in JAMA Internal Medicine, evaluated the influence of factors known to affect reproduction on the reproductive success of 325 women between the ages of 18 and 45 (mean age 35), who underwent in vitro fertilization (IVF). As reported by Time,3 The women in the study filled out detailed questionnaires about their diet, along with other factors that can affect IVF outcomes, like their age, weight and history of pregnancy and live births.

High Pesticide Exposure Associated With Reduced IVF Success

Using a U.S. government database listing average pesticide residues on food, the researchers estimated each participants pesticide exposure based on their food questionnaires. On average, women with high pesticide exposure ate 2.3 servings per day of fruits, berries or vegetables known to have high amounts of pesticide residue. Those in the lowest quartile ate less than 1 serving of high-pesticide produce per day.

Compared to women with the lowest pesticide exposure, women with the highest amounts of pesticide exposure had an 18 percent lower IVF success rate. They were also 26 percent less likely to have a live birth if they did become pregnant. Using modeling, the researchers estimate that exchanging a single serving of high-pesticide produce per day for one with low pesticide load may increase the odds of pregnancy by 79 percent, and the odds of having a live birth by 88 percent.

Pesticide Regulations Fail to Protect Human Health

Senior investigator Dr. Jorge Chavarro, associate professor of nutrition and epidemiology at Harvard T. H. Chan School of Public Health told Time:4

I was always skeptical that pesticide residues in foods would have any impact on health whatsoever. So, when we started doing this work a couple of years ago, I thought we were not going to find anything. I was surprised to see anything as far as health outcomes are concerned. I am now more willing to buy organic apples than I was a few months ago.

Coauthor Dr. Yu-Han Chiu, research fellow in the department of nutrition at the Harvard T.H. Chan School of Public Health, a...

Foods That Prevent Inflammation Also Enhance Your Brain Function Articles

By Dr. Mercola

It is important to realize that chronic inflammation often leads to chronic illnesses and health conditions, including obesity, heart disease, Type 2 diabetes, cancer and immune-mediated conditions. In fact, inflammation plays a significant role in seven of the top 10 leading causes of death.1

Inflammation is a normal part of your body's response to the environment to protect you from foreign invaders, such as bacteria, viruses and fungi. However, chronic, long-term inflammation increases your risks for devastating health conditions that may change the way you live or may even lead to death.

Many times, inflammation starts in your gut. Your intestines are a large and complex organ designed to pass nutrients to your body and gather waste to pass from your body. What you eat has a considerable effect on the permeability of your intestinal walls and how much waste or toxins may leak into your body. This leakage is a substantial driving force in the development of chronic inflammation.

The degree of permeability is in direct proportion to chemical mediators inside your intestines and in your bloodstream, in real time. This means that you can affect permeability immediately with the choices you make. However, repeated damage reduces the ability of the intestines to respond properly.

Eventually this may lead to impaired absorption of nutrients and overburden your immune system. Inflammation also has an effect on your brain. Recent research has found those with inflammatory markers in their 50s experienced a reduction in the size of their brain 24 years later.2

Inflammation May Lead to Reduced Brain Volume

This study provides more evidence that systemic inflammation may have lifelong effects on your health. The researchers took blood samples from a large, biracial community and analyzed five inflammatory markers at the start of the study and then again 24 years later. Those markers included levels of fibrinogen, albumin, white cell count, factor VIII and von Willebrand factor.3

Using these levels, the researchers created a composite score they could compare against other participant scores and MRI images taken at the conclusion of the study. The participants were divided into three groups based on the level of their inflammatory markers.4 When the gr...

More Proof Heartburn Products Are Dangerous Articles

By Dr. Mercola

Heartburn is a common condition and estimated to affect nearly 60 million Americans at least once a month.1 The pain is often described as sharp and burning, sometimes behind the breastbone and other times moving around the neck or throat. A Norwegian research team2 reported the incidence of people who experienced acid reflux at least once a week had increased by nearly 50 percent in the decade leading up to 2009.3

Occasional heartburn is not uncommon, but when the pain occurs frequently, or interferes with your daily routine, it may have become chronic heartburn.4 Your symptoms may be the result of a problem with your lower esophageal sphincter (LES) located between the stomach and esophagus. Normally, this sphincter keeps stomach acid in your stomach, only opening when you're swallowing or to let you belch.5

When your LES allows gastric acid to rise into your esophagus you experience the symptoms of heartburn, since the lining of your esophagus is not designed to withstand the acidic pH of stomach acid. With continued exposure to acid, the cells in the esophagus begin to adapt and become more like cells found in your small intestines.6 This is called Barrett's Esophagus and is a condition that increases your risk of developing esophageal cancer.

Previous research has found people taking a heartburn medication called proton pump inhibitors (PPIs), and who had infections with Helicobacter pylori (H. pylori), associated with the development of stomach ulcers, had a greater chance of developing cellular changes linked to stomach cancer.7 In recent research, scientists have now determined people taking PPIs, even after the infection had cleared, had a greater potential for developing stomach cancer as compared to those who were never infected.8

PPIs May Increase Your Risk of Cancer

Researchers from University College London and The University of Hong Kong found the risk of developing stomach cancer more than doubled when an individual took PPIs. To factor the potential role the infection plays in the development of stomach cancer, the researchers compared the use of PPIs to reduce acid reflux against people treated with triple therapy to kill H. pylori and then with H2 receptor antagonists such as...

15:28

Isoliquiritigenin could inhibit the growth of multiple myeloma via blocking IL-6 signalling. GreenMedInfo

PMID:  J Mol Med (Berl). 2012 Nov ;90(11):1311-9. Epub 2012 May 31. PMID: 22648519 Abstract Title:  Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. Abstract:  Previous studies have suggested that isoliquiritigenin (ISL) has anti-carcinogenic activity in several kinds of solid tumors, however, little is known about the effects of ISL on hematologic malignancies. In this study, we investigated the effects of ISL on multiple myeloma (MM) cells both in vitro and in vivo. The results showed that ISL could inhibit the growth of MM cells and induce their apoptosis in time- and dose-dependent manners. ISL exhibited significant anti-tumor activity in MM xenograft models and synergistically enhanced the anti-myeloma activity of adriamycin. Further analysis demonstrated that ISL not only downregulated IL-6 expression but also significantly decreased levels of phosphorylated ERK and STAT3 and could inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6, which are critical signaling proteins in IL-6 signaling regulation networks. Taken together, our findings suggested that ISL could inhibit the growth of MM via blocking IL-6 signaling and might serve as a promising therapeutic agent for treatment of MM.

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15:23

Isoliquiritigenin treatment induced apoptosis by increasing intracellular ROS levels in HeLa cells. GreenMedInfo

PMID:  J Asian Nat Prod Res. 2012 ;14(8):789-98. Epub 2012 Jun 14. PMID: 22694287 Abstract Title:  Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. Abstract:  This study focuses on the relationship between the apoptosis induced by isoliquiritigenin (ISL) and the production of reactive oxygen species (ROS). Cell viability was evaluated using sulforhodamine B assay. The apoptotic rate was determined via flow cytometry. Intracellular ROS level was assessed using the 2,7-dichlorofluorescein probe assay. Poly-ADP-ribose polymerase (PARP) protein expression was examined using Western blot analysis. The results showed that ISL treatment inhibited cell proliferation by inducing apoptosis. The increased apoptotic rate and ROS production induced by ISL were inhibited by the co-treatment of ISL and free radical scavenger N-acetyl-cysteine (NAC), catalase (CAT), and 4,5-dihydroxyl-1,3-benzededisulfonic acid (Tiron). On the contrary, the increased apoptotic rate and the ROS production were compensated by the co-treatment of ISL and l-buthionine-(S,R)-sulfoximine (BSO). ISL treatment increased the degradation of PARP, which was counteracted by antioxidants (NAC or CAT), whereas the combination treatment of ISL and pro-oxidant (BSO) enhanced the PARP degradation induced by ISL. Our findings suggested that ISL treatment induced apoptosis by increasing intracellular ROS levels in HeLa cells.

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15:14

This study investigated the mechanisms of isoliquiritigenin induced apoptosis in ovarian carcinoma SKOV-3 cells. GreenMedInfo

PMID:  Recent Pat Anticancer Drug Discov. 2013 May ;8(2):191-9. PMID: 22963151 Abstract Title:  Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis. Abstract:  Isoliquiritigenin (ISL), a licorice chalconoid, is a bioactive agent with chemopreventive potential that has been patented for tumor treatment in China. This study investigated the mechanisms of ISL-induced apoptosis in ovarian carcinoma SKOV-3 cells. Cell viability was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. The apoptotic rate was determined via flow cytometry using an annexin V-FITC apoptosis detection kit. The intracellular reactive oxygen species (ROS) levels were assessed using a 2,7-dichlorofluorescein probe assay. Malondialdehyde (MDA) formation was determined via thiobarbituric acid reactive substance test. The expressions of growth arrest and DNA damage-inducible gene (GADD153/CHOP), 78 kDa glucose-regulated protein (GRP 78),-subunit of eukaryotic initiation factor 2 (eIF2) phosphorylation, activating transcription factor 6 (ATF6), and unspliced form of X-box binding protein1 (XBP1U) were analyzed via Western blot. Caspase-3 and caspase-12 activities were assessed using a fluorometric kit. Findings indicate thatISL significantly inhibits SKOV-3 cell proliferation, increases intracellular ROS levels, and causes SKOV-3 cell apoptosis. Moreover, ISL-exposed SKOV-3 cells trigger endoplasmic reticulum (ER) stress, as indicated by the enhancement of ER stress-related molecules p-eIF2, GADD153/CHOP, GRP78, XBP1 expression, and cleavage of ATF6. However, caspase-12 inhibitor (Z-ATAD) effectively and partially prevents ROS and MDA formation and inhibits ISL-induced SKOV-3 cell apoptosis. ISL induces apoptosis via ER stress-triggered signaling pathways in SKOV-3 cells. ER stress-induced cancer cell apoptosis has been discussed in some patents.

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15:05

Vaccines cause diabetes another myth refuted and debunked Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

If you cruise around the internet, engaging with the antivaccination cult (not recommended), you will pick up on their standard tropes, lies, and other anti-science commentary. One that has always bothered me, not because that it was a lie, but because I had enough evidence floating in my brain that I was wondering if it

Skeptical Raptor

14:55

Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. GreenMedInfo

PMID:  Cell Biochem Biophys. 2013 Apr ;65(3):433-44. PMID: 23086355 Abstract Title:  Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. Abstract:  Redox balance plays an important role in the maintenance of cell growth and survival. Disturbance of this equilibrium can alter normal cellular processes. Excessive reactive oxygen species (ROS) are often found in cancer cells. However, cancer cells have an efficient antioxidant system to counteract the increased generation of ROS. This high antioxidant capacity also favors resistance to drugs and radiation. Here, we show that isoliquiritigenin (ISL), a natural antioxidant, effectively decreased ROS in HepG2 cells in a time-dependant manner at 0.5, 1, and 2 h of treatment. The decreased ROS caused redox imbalance and reductive stress. To adapt to this state, nuclear factor erythroid-2-related factor 2, which regulates the antioxidant enzyme system, was significantly decreased. Antioxidant enzymes reached their lowest level at 6 h after ISL treatment. Endogenous ROS were still being generated so after 6 h of ISL treatment, ROS were clearly higher than before ISL treatment, causing redox imbalance in the HepG2 cells which changed from reductive to oxidative stress. At this stage, cells were irradiated with X-rays. The excess ROS induced serious oxidative stress, resulting in radiosensitization. Therefore, we concluded that ISL induced oxidative stress by disturbing the redox status and ultimately enhancing the radiosensitivity of HepG2 cells.

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14:19

Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. GreenMedInfo

PMID:  Mol Med Rep. 2013 Feb ;7(2):531-6. Epub 2012 Dec 3. PMID: 23229626 Abstract Title:  Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. Abstract:  Isoliquiritigenin (ISL), a member of the flavonoids, has been demonstrated to possess antitumor activity in various cancer cell lines in vitro and in vivo. In this study, we investigated the antitumor effects of ISL on U87 glioma cells in vitro. As determined by MTT assay, ISL inhibited the proliferation of U87 cells in a time-dependent and dose-dependent manner. The results of fluorescence-activated cell sorting (FACS) analysis suggested that ISL induced the apoptosis of the U87 cells and blocked cell cycle progression at the S and G2/M phases. Moreover, it was identified that ISL induced the apoptosis of the U87 cells in a caspase-dependent manner. Although treatment with the pan-caspase inhibitor Z-VAD-FMK efficiently blocked the ISL-induced caspase activation, it did not eliminate the ISL-induced cell death. Further examination using western blot analysis revealed that ISL upregulated p21/WAF1 and p27. These results indicate that cell cycle arrest and the caspase-mediated apoptosis pathway may participate in the antiproliferative activity of ISL in U87 cells by regulating the expression of specific molecules.

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14:14

Isoliquiritigenin induces growth inhibition and apoptosis in human breast cancer cells. GreenMedInfo

PMID:  Toxicol Appl Pharmacol. 2013 Oct 1 ;272(1):37-48. Epub 2013 Jun 5. PMID: 23747687 Abstract Title:  Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Abstract:  Arachidonic acid (AA)-derived eicosanoids and its downstream pathways have been demonstrated to play crucial roles in growth control of breast cancer. Here, we demonstrate that isoliquiritigenin, a flavonoid phytoestrogen from licorice, induces growth inhibition and apoptosis through downregulating multiple key enzymes in AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. Isoliquiritigenin diminished cell viability, 5-bromo-2'-deoxyuridine (BrdU) incorporation, and clonogenic ability in both MCF-7 and MDA-MB-231cells, and induced apoptosis as evidenced by an analysis of cytoplasmic histone-associated DNA fragmentation, flow cytometry and hoechst staining. Furthermore, isoliquiritigenin inhibited mRNA expression of multiple forms of AA-metabolizing enzymes, including phospholipase A2 (PLA2), cyclooxygenases (COX)-2 and cytochrome P450 (CYP) 4A, and decreased secretion of their products, including prostaglandin E2 (PGE2) and 20-hydroxyeicosatetraenoic acid (20-HETE), without affecting COX-1, 5-lipoxygenase (5-LOX), 5-lipoxygenase activating protein (FLAP), and leukotriene B4 (LTB4). In addition, it downregulated the levels of phospho-PI3K, phospho-PDK (Ser(241)), phospho-Akt (Thr(308)), phospho-Bad (Ser(136)), and Bcl-xL expression, thereby activating caspase cascades and eventually cleaving poly(ADP-ribose) polymerase (PARP). Conversely, the addition of exogenous eicosanoids, including PGE2, LTB4 and a 20-HETE analog (WIT003), and caspase inhibitors, or overexpression of constitutively active Akt reversed isoliquiritigenin-induced apoptosis. Notably, isoliquiritigenin induced growth inhibition and apoptosis of MDA-MB-231 human breast cancer xenografts in nude mice, together with decreased intratumoral levels of eicosanoids and phospho-Akt (Thr(308)). Collectively, these data suggest that isoliquiritigenin induces growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in human breast cancer.

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14:06

Isoliquiritigenin inhibits breast cancer neoangiogenesis. GreenMedInfo

PMID:  PLoS One. 2013 ;8(7):e68566. Epub 2013 Jul 5. PMID: 23861918 Abstract Title:  Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. Abstract:  Angiogenesis is crucial for cancer initiation, development and metastasis. Identifying natural botanicals targeting angiogenesis has been paid much attention for drug discovery in recent years, with the advantage of increased safety. Isoliquiritigenin (ISL) is a dietary chalcone-type flavonoid with various anti-cancer activities. However, little is known about the anti-angiogenic activity of isoliquiritigenin and its underlying mechanisms. Herein, we found that ISL significantly inhibited the VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) at non-toxic concentration. A series of angiogenesis processes including tube formation, invasion and migration abilities of HUVECs were also interrupted by ISL in vitro. Furthermore, ISL suppressed sprout formation from VEGF-treated aortic rings in an ex-vivo model. Molecular mechanisms study demonstrated that ISL could significantly inhibit VEGF expression in breast cancer cells via promoting HIF-1 (Hypoxia inducible factor-1) proteasome degradation and directly interacted with VEGFR-2 to block its kinase activity. In vivo studies further showed that ISL administration could inhibit breast cancer growth and neoangiogenesis accompanying with suppressed VEGF/VEGFR-2 signaling, elevated apoptosis ratio and little toxicity effects. Molecular docking simulation indicated that ISL could stably form hydrogen bonds and aromatic interactions within the ATP-binding region of VEGFR-2. Taken together, our study shed light on the potential application of ISL as a novel natural inhibitor for cancer angiogenesis via the VEGF/VEGFR-2 pathway. Future studies of ISL for chemoprevention or chemosensitization against breast cancer are thus warranted.

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13:42

Isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes. GreenMedInfo

PMID:  Mediators Inflamm. 2013 ;2013:390890. Epub 2013 Sep 16. PMID: 24163504 Abstract Title:  Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Abstract:  Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco. Reactive oxygen species (ROS) is a critical factor involved in modulating cardiac stress response signaling during ischemia and reperfusion. We hypothesize that ISL as a natural antioxidant may protect heart against ischemic injury via modulating cellular redox status and regulating cardioprotective signaling pathways. The fluorescent probe H2DCFDA was used to measure the level of intracellular ROS. The glucose uptake was determined by 2-deoxy-D-glucose-(3)H accumulation. The IonOptix System measured the contractile function of isolated cardiomyocytes. The results demonstrated that ISL treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia. ISL significantly stimulated cardioprotective signaling, AMP-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK) signaling pathways. The ROS fluorescent probe H2DCFDA determination indicated that ISL significantly reduced cardiac ROS level during hypoxia/reoxygenation. Moreover, ISL reduced the mitochondrial potential () of isolated mouse cardiomyocytes. Taken together, ISL as a natural antioxidant demonstrated the cardioprotection against ischemic injury that may attribute to the activation of AMPK and ERK signaling pathways and balance of cellular redox status.

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13:31

These results suggest a potential benefit of isoliquiritigenin for cervical cancer prevention and treatment. GreenMedInfo

PMID:  Planta Med. 2013 Nov ;79(17):1628-35. Epub 2013 Nov 8. PMID: 24214831 Abstract Title:  Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. Abstract:  Flavonoids have antitumoral properties and may be attractive candidates as anticancer therapy. Isoliquiritigenin which is a constituent of licorice (Glycyrrhiza inflata), a plant commonly used in traditional Uyghur medicine in Xinjiang, China, was studied for antiproliferative and apoptotic activity in human cervical cancer cells, Ca Ski, SiHa, HeLa, and C-33A. Its molecular mechanism of action was specifically examined in Ca Ski cells. Isoliquiritigenin decreased cell viability, induced cell accumulation in G2/M and morphological and biochemical features of apoptosis in the four cancer cell lines. In Ca Ski cells, isoliquiritigenin led to a downregulation of HPV16 E6 expression associated with an increase of p53 and p21 levels, enhanced expression of Bax and decreased expression of Bcl-2 and Bid proform triggering dissipation of the mitochondrial membrane potential, released cytochrome c to the cytosol followed by activation of caspase cascade with cleavage of caspase-9, caspase-3, and PARP. Caspase-8 was also cleaved. Moreover treatment with a pan-caspase inhibitor prevented apoptosis. As Ca Ski cells are representative of carcinoma naturally occurring in the cervix, our results suggest a potential benefit of isoliquiritigenin for cervical cancer prevention and treatment.

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13:21

Glycyrrhiza uralensis and other Glycyrrhiza species have anti-hepatitis C virus compounds. GreenMedInfo

PMID:  Microbiol Immunol. 2014 Mar ;58(3):180-7. PMID: 24397541 Abstract Title:  Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Abstract:  Development of complementary and/or alternative drugs for treatment of hepatitis C virus (HCV) infection is still much needed from clinical and economic points of view. Antiviral substances obtained from medicinal plants are potentially good targets to study. Glycyrrhiza uralensis and G. glabra have been commonly used in both traditional and modern medicine. In this study, extracts of G. uralensis roots and their components were examined for anti-HCV activity using an HCV cell culture system. It was found that a methanol extract of G. uralensis roots and its chloroform fraction possess anti-HCV activity with 50%-inhibitory concentrations (IC(50)) of 20.0 and 8.0g/mL, respectively. Through bioactivity-guided purification and structural analysis, glycycoumarin, glycyrin, glycyrol and liquiritigenin were isolated and identified as anti-HCV compounds, their IC(50) being 8.8, 7.2, 4.6 and 16.4g/mL, respectively. However, glycyrrhizin, the major constituent of G. uralensis, and its monoammonium salt, showed only marginal anti-HCV activity. It was also found that licochalcone A and glabridin, known to be exclusive constituents of G. inflata and G. glabra, respectively, did have anti-HCV activity, their IC(50) being 2.5 and 6.2g/mL, respectively. Another chalcone, isoliquiritigenin, also showed anti-HCV activity, with an IC(50) of 3.7g/mL. Time-of-addition analysis revealed that all Glycyrrhiza-derived anti-HCV compounds tested in this study act at the post-entry step. In conclusion, the present results suggest that glycycoumarin, glycyrin, glycyrol and liquiritigenin isolated from G. uralensis, as well as isoliquiritigenin, licochalcone A and glabridin, would be good candidates for seed compounds to develop antivirals against HCV.

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12:49

Isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells. GreenMedInfo

PMID:  Carcinogenesis. 2014 Nov ;35(11):2544-54. Epub 2014 Sep 6. PMID: 25194164 Abstract Title:  Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via-catenin/ABCG2 signaling. Abstract:  Accumulating evidence suggests that-catenin signaling in breast cancer stem cells (CSCs) is closely correlated to chemoresistance and adenosine triphosphate (ATP)-binding cassette subfamily G2 (ABCG2) expression. Targeting the aberrant -catenin signaling in CSCs has become a promising strategy to improve chemosensitivity in cancer treatment. In a pilot screening study, we found that the natural compound isoliquiritigenin (ISL) blocked -catenin transcription activity with the highest inhibition ratio. Here, we investigated the chemosensitizing effects of ISL on breast CSCs and the underlying mechanisms regulating the -catenin pathway. ISL could have synergistic effects with chemotherapeutic drugs to inhibit breast cancer cell proliferation and colony formation. In addition, ISL could significantly limit the side population and CSC ratios in breast cancer cells, accompanied by inhibited self-renewal and multidifferentiation abilities. A mechanistic study revealed that ISL could inhibit -catenin/ABCG2 signaling by activating the proteasome degradation pathway. The drug affinity responsive target stability strategy further identified GRP78 as the direct target of ISL. Subsequent molecular docking analysis andfunctional studies demonstrated that ISL could dock into the ATP domain of GRP78 and thereby inhibit its ATPase activity, resulting in its dissociation from -catenin. An in vivo study also suggested that ISL could chemosensitize breast CSCs via the GRP78/-catenin/ABCG2 pathway, with little toxicity in normal tissues and mammary stem cells. Taken together, the data from this study not only suggest ISL as a natural candidate to enhance breast CSC chemosensitivity but also highlight the significance of GRP78 in mediating cancer drug resistance and -catenin signaling in CSCs.

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12:36

Isoliquiritigenin is a potential drug target for treatment of NLRP3 inflammasome-associated inflammatory diseases. GreenMedInfo

PMID:  J Leukoc Biol. 2014 Dec ;96(6):1087-100. Epub 2014 Sep 10. PMID: 25210146 Abstract Title:  Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. Abstract:  Inflammasome activation initiates the development of many inflammatory diseases, including obesity and type 2 diabetes. Therefore, agents that target discrete activation steps could represent very important drugs. We reported previously that ILG, a chalcone from Glycyrrhiza uralensis, inhibits LPS-induced NF-B activation. Here, we show that ILG potently inhibits the activation of NLRP3 inflammasome, and the effect is independent of its inhibitory potency on TLR4. The inhibitory effect of ILG was stronger than that of parthenolide, a known inhibitor of the NLRP3 inflammasome. GL, a triterpenoid from G.uralensis, had similar inhibitory effects on NLRP3 activity, but high concentrations of GL were required. In contrast, activation of the AIM2 inflammasome was inhibited by GL but not by ILG. Moreover, GL inhibited NLRP3- and AIM2-activated ASC oligomerization, whereas ILG inhibited NLRP3-activatedASC oligomerization. Low concentrations of ILG were highly effective in IAPP-induced IL-1 production compared with the sulfonylurea drug glyburide. In vivo analyses revealed that ILG potently attenuated HFD-induced obesity, hypercholesterolemia, and insulin resistance. Furthermore, ILG treatment improved HFD-induced macrovesicular steatosis in the liver. Finally, ILG markedly inhibited diet-induced adipose tissue inflammation and IL-1 and caspase-1 production in white adipose tissue in ex vivo culture. These results suggest that ILG is a potential drug target for treatment of NLRP3 inflammasome-associated inflammatory diseases.

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12:20

Isoliquiritigenin suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR. GreenMedInfo

PMID:  J Biol Chem. 2014 Dec 26 ;289(52):35839-48. Epub 2014 Nov 3. PMID: 25368326 Abstract Title:  Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. Abstract:  Non-small-cell lung cancer (NSCLC) is associated with diverse genetic alterations including mutation of epidermal growth factor receptor (EGFR). Isoliquiritigenin (ILQ), a chalcone derivative, possesses anticancer activities. In the present study, we investigated the effects of ILQ on the growth of tyrosine kinase inhibitor (TKI)-sensitive and -resistant NSCLC cells and elucidated its underlying mechanisms. Treatment with ILQ inhibited growth and induced apoptosis in both TKI-sensitive and -resistant NSCLC cells. ILQ-induced apoptosis was associated with the cleavage of caspase-3 and poly-(ADP-ribose)-polymerase, increased expression of Bim, and reduced expression of Bcl-2. In vitro kinase assay results revealed that ILQ inhibited the catalytic activity of both wild type and double mutant (L858R/T790M) EGFR. Treatment with ILQ inhibited the anchorage-independent growth of NIH3T3 cells stably transfected with either wild type or double-mutant EGFR with or without EGF stimulation. ILQ also reduced the phosphorylation of Akt and ERK1/2 in both TKI-sensitive and -resistant NSCLC cells, and attenuated the kinase activity of Akt1 and ERK2 in vitro. ILQ directly interacted with both wild type and double-mutant EGFR in an ATP-competitive manner. A docking model study showed that ILQ formed two hydrogen bonds (Glu-762 and Met-793) with wild type EGFR and three hydrogen bonds (Lys-745, Met-793, and Asp-855) with mutant EGFR. ILQ attenuated the xenograft tumor growth of H1975 cells, which was associated with decreased expression of Ki-67 and diminished phosphorylation of Akt and ERK1/2. Taken together, ILQ suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR.

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12:14

Plague Outbreak Grows as 10th Nation Put on Alert REALfarmacy.com

Source: Plague Outbreak Grows as 10th Nation Put on Alert For more content like this visit REALfarmacy.com.

The deadly plague disease has been spreading across the island nation of Madagascar killing at least 143 people. More than 2,000 others have been infected since the outbreak began. Lately, over 1,300 cases have been reported in Madagascar alone which made health chiefs in nearby nations place their countries on high alert. Malawi, South Africa, Mauritius, Seychelles, Tanzania, La Runion, Mozambique, []

Source: Plague Outbreak Grows as 10th Nation Put on Alert Learn more at REALfarmacy.com - Healthy News and Information.

12:12

Isoliquiritigenin has a protective effect against carbon tetrachloride-induced liver damage. GreenMedInfo

PMID:  Chem Biol Interact. 2015 Jan 5 ;225:13-20. Epub 2014 Nov 6. PMID: 25450236 Abstract Title:  Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. Abstract:  Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats. CCl4 (0.5 ml/kg/d, twice) or CCl4 plus buthionine sulfoximine exerted severe liver damage assessed by increased plasma levels of alanine aminotransferase and aspartate aminotransferase, in addition to hepatic degeneration and necrosis. These pathological changes were markedly protected by pretreatment with isoLQ (5, 20 mg/kg/d, p.o.) for 3 consecutive days. In addition, pretreatment with isoLQ inhibited CCl4-induced reduction of cytochrome P450 2E1 protein and mRNA expression as well as activity in the liver. Moreover, isoLQ pretreatment reversed the decrease in hepatic antioxidant capacity induced by CCl4 as well as suppressed expression of tumor necrosis factor-alpha and cyclooxigenase-2 in the liver. These results suggest that isoLQ has a protective effect against CCl4-induced liver damage through induction of antioxidant and anti-inflammatory activities.

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12:02

Positive Pregnancy Test: When and How Long After Implantation Healthy and Natural World

A pregnancy test can show a positive result a few days after implantation has occurred. Most women who want to get pregnant are very keen to take a home pregnancy test (HPT) to see if the result is positive. Depending on your body and the levels of hCG hormone, early pregnancy can be detected by a pregnancy blood test as soon as 3-4 days after implantation. Usually, a urine home pregnancy test takes a few days longer to detect a pregnancy and may show a positive result as soon as 5-7 days after implantation.

Even if the home pregnancy test result is negative, it doesnt necessarily mean that you are not pregnant. How soon an early pregnancy can be detected depends on the levels of the hormone called human chorionic gonadotropin (hCG). This hormone is produced during pregnancy. Blood and urine pregnancy tests check for elevated levels of hCG which start to rise right after implantation. A positive urine home pregnancy test will undoubtedly mean that you are pregnant and should visit your doctor for hCG blood test.

Most home urine pregnancy test kits advise that you should wait until the first day of your missed period before taking the test. This is when levels of hCG will usually be high enough for the majority of pregnancy testing kits to show a positive pregnancy result if you have conceived. However, some urine pregnancy testing kits are more sensitive and may be able to show a positive result and detect early pregnancy quite soon after implantation.

If you have already waited for a few days after your missed period to take a pregnancy test, and it is still negative, chances are that you are not pregnant.

You may want to take a pregnancy test, but you probably have questions such as: How long after implantation can I test? How long do I have to wait after a missed period before I take a test? In this article, you will find out how early you can detect pregnancy using at-home pregnancy testing kits. You will also learn about the other early signs of pregnancy that can help determine if implantation has taken place.

How Long After Implantation You Need to Take a Pregnancy Test

How early you can take a pregnancy test depends on a number of factors such as the sensitivity of the home pregnancy test (HPT), levels of human chorionic gonadotropin (hCG) in your body, and the regularity of your menstrual cycle.

A pregnancy test can only become positive when an egg is fertilized after ovulation. According to the American Pregnancy Association, ovulation happens about 11 to 21 days from the start of your last period.1 At ovulation, an egg is released and lives for up to 24 hours in the fallopian tubes waiting for a sperm that lives long enough to fertilize it. Some signs of ovulation include dis...

11:58

Isoliquiritigenin stimulates the detoxification system via Nrf2 activation. GreenMedInfo

PMID:  J Ethnopharmacol. 2015 Mar 13 ;162:134-9. Epub 2014 Dec 31. PMID: 25557030 Abstract Title:  A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Licorice (Glycyrrhizae radix), the root of Glycyrrhiza uralensis Fisch. (Leguminosae), is mainly used to moderate the characteristics of toxic herbs in Traditional Chinese Medicine, which could be partly interpreted as detoxification. However, the underlying mechanism is still not fully elucidated. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the protection against toxic xenobiotics. In our previous research, we have identified that extracts from Glycyrrhiza uralensis induced the expression of Nrf2 nuclear protein and its downstream genes. This research aims to screen the most potent Nrf2 inducer isolated from Glycyrrhiza uralensis and examine its effect on Nrf2 signaling pathway and detoxification system.MATERIALS AND METHODS: Four compounds derived from Glycyrrhiza uralensis (glycyrrhetinic acid, liquiritigenin, isoliquiritigenin and liquiritin) were screened by ARE-luciferase reporter. The most potent ARE-luciferase inducer was chosen to further examine its effect on Nrf2 and detoxification genes in HepG2 cells. The role of Nrf2-dependent mechanism was tested by using Nrf2 knockout mice (Nrf2 KO) and Nrf2 wild-type mice (Nrf2 WT).RESULTS: ARE-luciferase reporter assay showed these four compounds were all potent Nrf2 inducers, and isoliquiritigenin was the most potent inducer. Isoliquiritigenin significantly up-regulated the expression of Nrf2 and its downstream detoxification genes UDP-glucuronosyltransferase 1A1 (UGT1A1), glutamate cysteine ligase (GCL), multidrug resistance protein 2 (MRP2) and bile salt export pump (BSEP) in vitro and in vivo. Additionally, isoliquiritigenin showed Nrf2-dependent transactivation of UGT1A1, GCLC and MRP2.CONCLUSIONS: Isoliquiritigenin, isolated from Glycyrrhiza uralensis, stimulates detoxification system via Nrf2 activation, which could be a potential protective mechanism of licorice.

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11:48

Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid- toxicity in Caenorhabditis elegans. GreenMedInfo

PMID:  Planta Med. 2015 Mar ;81(5):357-62. Epub 2015 Mar 17. PMID: 25782036 Abstract Title:  Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid- toxicity in Caenorhabditis elegans. Abstract:  Alzheimer's disease is a rising threat for modern societies as more and more people reach old age. To date, there is no effective treatment for this condition. In this study, we investigated the potential of Glycyrrhiza uralensis to counteract amyloid- toxicity, one of the key features of Alzheimer's disease. An LC-MS/MS analysis revealed glycyrrhizic acid and glycosylated forms of isoliquiritigenin and liquiritigenin as major constituents of water and methanol extracts of G. uralensis. These extracts and the pure compounds were tested for their activity in two Caenorhabditis elegans models of amyloid- aggregation and amyloid- toxicity, respectively. The number of amyloid- aggregates decreased by 30% after treatment with isoliquiritigenin, the methanol extract could reduce the number by 14%, liquiritigenin and glycyrrhizic acid by 15%, and the aglycon of glycyrrhizic acid, glycyrrhetinic acid, by 20%. Both extracts and isoliquiritigenin also showed significant activity against acute amyloid- toxicity in transgenic C. elegans that express human amyloid- peptides, delaying the paralysis in this model by 1.8 h and 1.1 h, respectively. We conclude that secondary compounds of G. uralensis may become interesting drug candidates for the treatment of Alzheimer's disease, which, however, need further analysis in other model systems.

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11:39

Isoliquiritigenin prevented the occurrence of gastric ulcers by indomethacin. GreenMedInfo

PMID:  Planta Med. 2015 May ;81(7):586-93. Epub 2015 Apr 15. PMID: 25875506 Abstract Title:  In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. Abstract:  As numerous herbal products have been used as dietary supplements or functional foods, the demands of the pharmacokinetic and pharmacodynamic characteristics of active compounds are increasing in order to secure a consistent outcome (i.e., efficiency and safety). In this study, the pharmacokinetics including tissue distribution, metabolism, and protein binding of isoliquiritigenin, a chalcone found in Glycyrrhiza glabra, and its metabolite, liquiritigenin, at various doses in mice are reported. Also, correlations between the preferential tissue distribution and pharmacological effect of isoliquiritigenin in certain organs were investigated using the in vivo gastroprotective effect of isoliquiritigenin in mice with indomethacin-induced ulcer. The absorbed fraction of isoliquiritigenin was high, but the absolute bioavailability was low mainly due to its metabolism. In spite of the low bioavailability, the gastroprotective effect of isoliquiritigenin was attributed to its high distribution in the stomach. Isoliquiritigenin prevented the occurrence of gastric ulcers by indomethacin, which is associated with increased gastric mucous secretion because the pretreatment with isoliquiritigenin presumably counteracted the decreased cyclooxygenase 2 by indomethacin. This may suggest that the pharmacokinetic properties of isoliquiritigenin are useful to predict its efficacy as a gastroprotective agent in a target organ such as the stomach.

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11:32

Quercetin could be a promising candidate for antiviral and antitumor agents against EBV and human gastric carcinoma. GreenMedInfo

PMID:  Oncotarget. 2015 May 20 ;6(14):12603-24. PMID: 26059439 Abstract Title:  Quercetin-induced apoptosis prevents EBV infection. Abstract:  Epstein-Barr virus (EBV) is a human gamma-1 herpesvirus that establishes a lifelong latency in over 90% of the world's population. During latency, virus exists predominantly as a chromatin-associated, multicopy episome in the nuclei of a variety of tumor cells derived from B cells, T cells, natural killer (NK) cells, and epithelial cells. Licorice is the root of Glycyrrhiza uralensis or G. glabra that has traditionally cultivated in eastern part of Asia. Licorice was reported to have anti-viral, anti-inflammatory, anti-atopic, hepatoprotective, anti-neurodegenerative, anti-tumor, anti-diabetic effects and so forth. Quercetin and isoliquiritigenin are produced from licorice and highly similar in molecular structure. They have diverse bioactive effects such as antiviral activity, anti-asthmatic activity, anti-cancer activity, anti-inflammation activity, monoamine-oxidase inhibitor, and etc. To determine anti-EBV and anti-EBVaGC (Epstein-Barr virus associated gastric carcinoma) effects of licorice, we investigated antitumor and antiviral effects of quercetin and isoliquiritigenin against EBVaGC. Although both quercetin and isoliquiritigenin are cytotoxic to SNU719 cells, quercetin induced more apoptosis in SNU719 cells than isoliquiritigenin, more completely eliminated DNMT1 and DNMT3A expressions than isoliquiritigenin, and more strongly affects the cell cycle progression of SNU719 than isoliquiritigenin. Both quercetin and isoliquiritigenin induce signal transductions to stimulate apoptosis, and induce EBV gene transcription. Quercetin enhances frequency of F promoter use, whereas isoliquiritigenin enhances frequency of Q promoter use. Quercetin reduces EBV latency, whereas isoliquiritigenin increases the latency. Quercetin increases more the EBV progeny production, and inhibits more EBV infection than isoliquiritigenin. These results indicate that quercetin could be a promising candidate for antiviral and antitumor agents against EBV and human gastric carcinoma.

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11:27

Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. GreenMedInfo

PMID:  Oncotarget. 2015 ;6(12):9854-76. PMID: 25918249 Abstract Title:  Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. Abstract:  Breast cancer stem cells (CSCs) are considered as the root of mammary tumorigenesis. Previous studies have demonstrated that ISL efficiently limited the activities of breast CSCs. However, the cancer prevention activities of ISL and its precise molecular mechanisms remain largely unknown. Here, we report a novel function of ISL as a natural demethylation agent targeting WIF1 to prevent breast cancer. ISL administration suppressed in vivo breast cancer initiation and progression, accompanied by reduced CSC-like populations. A global gene expression profile assay further identified WIF1 as the main response gene of ISL treatment, accompanied by the simultaneous downregulation of-catenin signaling and G0/G1 phase arrest in breast CSCs. In addition, WIF1 inhibition significantly relieved the CSC-limiting effects of ISL and methylation analysis further revealed that ISL enhanced WIF1 gene expression via promoting the demethylation of its promoter, which was closely correlated with the inhibition of DNMT1 methyltransferase. Molecular docking analysis finally revealed that ISL could stably dock into the catalytic domain of DNMT1. Taken together, our findings not only provide preclinical evidence to demonstrate the use of ISL as a dietary supplement to inhibit mammary carcinogenesis but also shed novel light on WIF1 as an epigenetic target for breast cancer prevention.

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11:16

Isoliquiritigenin could improve the spatial learning and memory lesions induced by high fat diet. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2015 Sep 4 ;464(4):1090-5. Epub 2015 Jul 17. PMID: 26188513 Abstract Title:  The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-/JNK/IRS signaling. Abstract:  Isoliquiritigenin (ILG), a chalcone from Glycyrrhiza uralensis, has various biological properties. ILG markedly inhibited inflammation, but the effects on the brain inflammation and insulin resistance induced by high-fat diet (HFD) are still unknown, so our study intended to investigate its effect on cognitive dysfunction induced by HFD and the relevant mechanisms. ICR mice were treated with HFD diet for 8 weeks to induce peripheral insulin resistance prior to being intervened with rosiglitazone, ILG (30, 60 mg/kg). 4 weeks later, Morris Water Maze (MWM) was used to assess the learning and memory, the insulin resistance index was measured, and the brain inflammation cytokines (IL-1, TNF-) were assessed. Meanwhile, the p-JNK, p-IRS Ser(307) protein expressions in the hippocampus were also detectedusing the western blot to explore the corresponding mechanisms. Our results suggested that ILG could significantly alleviate the cognitive impairments in the MWM test and attenuate peripheral insulin resistance. The IL-1, TNF- levels declined with the administration of ILG, meanwhile the p-IRS Ser(307) expression decreased with the inhibition of p-JNK. In conclusion, ILG could improve the spatial learning and memory lesions induced by HFD via the inhibition of TNF-/JNK/IRS pathway.

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11:12

5 LIFESTYLE Changes for BATTLING DEPRESSION: Maybe Its Time for a TUNE-UP? Chipur

The basics: the very foundation of optimal performance. As crucial as they are, they're often forgotten in the whirlwind of life, and we end-up paying for it. Every now and then we need a tune-up. Great reading, so come on in...

10:31

Isoliquiritigenin has the function of being a hepatic protectant against oxidative damages through ERK-mediated Nrf2 activation. GreenMedInfo

PMID:  Eur J Nutr. 2016 Dec ;55(8):2431-2444. Epub 2015 Nov 22. PMID: 26593436 Abstract Title:  Isoliquiritigenin in licorice functions as a hepatic protectant by induction of antioxidant genes through extracellular signal-regulated kinase-mediated NF-E2-related factor-2 signaling pathway. Abstract:  PURPOSE: Liver is the major site of biotransformation for exogenous toxins, in having a defense system against oxidative stress as well as cytochrome P450 system. Isoliquiritigenin (isoLQ) is an active component present in Glycyrrhizae radix and has been shown to have various biological activities. This study investigated the effect of isoLQ as a liver protectant against oxidative stress, both in vivo and in vitro, and also its molecular mechanisms.METHODS: We used tert-butylhydroperoxide-induced hepatocyte damage model and cadmium (Cd)-stimulated liver toxicity animal model, which are assessed by immunoblot and flow cytometry as well as plasma and histopathological parameters.RESULTS: In HepG2 cells, pretreatment of 10 and 30 M isoLQ significantly inhibited the induction of apoptosis and mitochondrial damage, and production of reactive oxygen species. Moreover, isoLQ induced the activation of nuclear factor erythroid 2-related factor-2 (Nrf2), as indicated by an increase in its nuclear translocation and antioxidant response element-luciferase activity. IsoLQ also induced the expression of Nrf2 target phase II enzymes, such as heme oxygenase-1, glutamate-cysteine ligase catalytic subunit and NAD(P)H:quinone oxidoreductase 1. IsoLQ also induced phosphorylation of extracellular stimuli-regulated kinase (ERK), andits activation of Nrf2 was mediated with ERK-dependent phosphorylation of Nrf2, as determined by its chemical inhibitor. In rats, oral treatment of 5 and 20 mg/kg isoLQ prevented Cd-induced acute hepatic damage, as assessed by plasma parameters and semiquantative histology, such as the modified HAIgrading scores and the degenerative regions in hepatic parenchyma.CONCLUSION: These findings are considered as scientific evidence that isoLQ in licorice has the function of being a hepatic protectant against oxidative damages through ERK-mediated Nrf2 activation.

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10:06

Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. GreenMedInfo

PMID:  Int J Clin Exp Pathol. 2015 ;8(10):12577-82. Epub 2015 Oct 1. PMID: 26722447 Abstract Title:  Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. Abstract:  OBJECTIVE: To investigate the effect of isoliquiritigenin on the activity of DNA topoisomerase (TOP I) and its inhibitory effect on the growth of U87 glioma cells.METHODS: This study investigated the inhibitory effect of isoliquiritigenin on the growth of U87 glioma cells and its cytotoxicity by MTT method and determined the effect of isoliquiritigenin on TOP I activity by agarose gel electrophoresis. On this basis, we studied the interaction between isoliquiritigenin and TOP I and DNA. Finally, we further discussed the effect of isoliquiritigenin on the activity of Caspase 3, the apoptosis protein of U87 glioma cells.RESULTS: Isoliquiritigenin could inhibit the growth of U87 glioma cells (half inhibitory concentration IC50: 0.221 mM) and is of low cytotoxicity to normal cells. Agarose gel electrophoresis showed that isoliquiritigenin had significant inhibitory effect on TOP I activity. Molecular simulation results indicated that isoliquiritigenin took priority of binding to the active center of TOP I, and formed hydrogen bonds with the catalytic site Try723. Finally, Caspase 3 activity detection results suggested that isoliquiritigenin could significantly increase the activity of Caspase 3 (P

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10:00

EPA Approves Lab Infected Killer Mosquitoes to be Released into the Environment Health Impact News

Female_Asian_tiger_mosquito

The lab-grown mosquitoes developed by MosquitoMate seek to eliminate the disease-carrying Asian tiger mosquito (Aedes albopictus, shown here). Image from Nature.com.

by Paul Fassa
Health Impact News

The US Environmental Protection Agency (EPA) has approved the use of laboratory infected mosquitoes carrying the bacterium Wolbachia pipientis to be released into the wild. The laboratory-raised mosquitoes are meant to be a way to infect Asian Tiger mosquitoes, which are believed to carry harmful infectious diseases.

The long term environmental consequences are unknown. Because mosquitoes are prey for birds and fish, the long-term effects on the greater ecosystem are unclear.

Killer Mosquitoes Safer than Genetically Modified Mosquitoes?

Most welcome the effort at hampering mosquitoes reproductive potential as a welcome alternative to various aerial and land-based mass chemical spraying activities that add to our toxic environments, ultimately endangering human and animal health.

After the backlash against releasing genetically modified mosquitoes that would disrupt the reproductive cycles of the Aedes aegypti or Asian Tiger Mosquito, considered a major carrier of the most dangerous mosquito-borne infectious diseases, MosquitoMate, a start-up company with the help of Kentucky Universitys laboratories and researchers, discovered what the EPA considers an acceptable alternative for mosquito control.

David OBrochta, an entomologist at the University of Maryland, endorsed the EPAs approval:

Its a non-chemical way of dealing with mosquitoes, so from that perspective, youd think it would have a lot of appeal. Im glad to see it pushed forward, as I think it could be potentially really important. (Source)

Unlike genetically modified mosquitoes that drew popular resistance against being used in the Florida Keys, lab produced male mosquitoes that are intentionally infected with the Walbachia bacterium that prevents the female mosquitoes eggs from hatching are considered less of a potential ecological hazard to effectively diminish mosquito breeding than genetic...

09:35

Isoliquiritigenin may have inhibitory potential on breast cancer-induced bone destruction. GreenMedInfo

PMID:  J Cancer Prev. 2015 Dec ;20(4):281-6. Epub 2015 Dec 30. PMID: 26734591 Abstract Title:  Isoliquiritigenin Inhibits Metastatic Breast Cancer Cell-induced Receptor Activator of Nuclear Factor Kappa-B Ligand/Osteoprotegerin Ratio in Human Osteoblastic Cells. Abstract:  Bone destruction induced by the metastasis of breast cancer cells is a frequent complication that is caused by the interaction between cancer cells and bone cells. Receptor activator of nuclear factor kappa-B ligand (RANKL) and the endogenous soluble RANKL inhibitor, osteoprotegerin (OPG), directly play critical roles in the differentiation, activity, and survival of osteoclasts. In patients with bone metastases, osteoclastic bone resorption promotes the majority of skeletal-related events and propagates bone metastases. Therefore, blocking osteoclast activity and differentiation via RANKL inhibition can be a promising therapeutic approach for cancer-associated bone diseases. We investigated the potential of isoliquiritigenin (ISL), which has anti-proliferative, anti-angiogenic, and anti-invasive effects, as a preventive and therapeutic agent for breast cancer cell-induced bone destruction. ISL at non-toxicity concentrations significantly inhibited the RANKL/OPG ratio by reducing the production of RANKL and restoring OPG production to control levels in hFOB1.19 cells stimulated with conditioned medium (CM) of MDA-MB-231 cells. In addition, ISL reduced the expression of cyclooxygenase-2 in hFOB1.19 cells stimulated by CM of MDA-MB-231 cells. Therefore, ISL may have inhibitory potential on breast cancer-induced bone destruction.

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09:24

This Pineapple Cough Remedy Is 5x More Effective Than Cough Medicine Natural Blaze

pineapple juice cough remedy

By 

5x More Effective Than Cough Medicine This Overlooked Fruit Will Be Your Favorite New Cough Remedy

Pineapple Juice for Cough: Effective Homemade Cough Remedies

Pineapple is a delicious, nutrient-dense tropical fruit with a lot of health benefits. But when it comes to over-the-counter cough suppressant syrups, is pineapple juice for cough relief a better natural remedy?

Pineapple juice for sore throats and coughs may be the remedy for you. Research suggests that pineapple juice is indeed five times more effective than cough syrup. An enzyme called bromelain in pineapple is a key reason for that. As a result, Amish populations have been using pineapple juice for generations as an alternative to those synthetic cough remedies that many people use today.

This article will detail exactly how pineapple juice is effective against coughs. We will also provide many pineapple recipes for cough, including how to make cough syrup with a number of natural cough remedies.

Disclaimer: Results are not guaranteed*** and may vary from person to person***.

Why Pineapple Juice Is Effective against Cough

Is pineapple juice good for a cough? Pineapple juice may treat a persistent cough...

09:21

Isoliquiritigenin has potential activity to ameliorate the dextran sulfate sodium induced colitis. GreenMedInfo

PMID:  Int Immunopharmacol. 2016 Feb ;31:223-32. Epub 2016 Jan 7. PMID: 26771170 Abstract Title:  Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway. Abstract:  Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate sodium (DSS)-induced colitis by observing the physiological changes (body weight loss, diarrhea, bleeding stool, overall disease activity index (DAI) scores, colon length), histopathological analysis and myeloperoxidase (MPO) activities of esophagus and colon. Also, the MAPK pathways including phosphorylation of ERK1/2, p38, and AKT, and the activation of NK-B were evaluated in colon tissue. Interestingly, the reduction of body weight and colon length, increase of diarrhea, bloody stool, DAI scores and MPO activity, and histologic disturbances in DSS-induced colitis were recovered by isoLQ treatment. Also, isoLQ treatment suppressed the phosphorylation of ERK1/2 and p38, and the activation of NK-B compared to those in DSS-induced colitis mice. In addition, the distributions of isoLQ in colon were relatively higher in DSS-induced colitis models. All of these results suggested that isoLQ has potential activity to ameliorate the DSS-induced colitis through the inhibition of MAPK pathway.

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09:21

Anti-vaccine pseudoscience Shaw and Tomljenovic debunked tropes Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Im beginning to feel some deja vu, since I am criticizing another anti-vaccine pseudoscience paper foisted onto the world by Christopher Shaw and Lucija Tomljenovic. These two University of British Columbia (UBC) researchers in the Department of Ophthalmology (you know, the study of eyes) have no background or training in any area vaccine research, including immunology, epidemiology,

Skeptical Raptor

09:10

Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-B-dependent autophagic pathway. GreenMedInfo

PMID:  Biochem Pharmacol. 2016 Apr 15 ;106:82-93. Epub 2016 Mar 3. PMID: 26947453 Abstract Title:  Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-B-dependent autophagic pathway. Abstract:  Previous studies, including those from our laboratory, have demonstrated that the natural flavonoid isoliquiritigenin (ISL) is a promising agent for bone destructive diseases. However, the mechanisms underlying its anti-osteoclastogenic effects are still far from clear. Here, we evaluated the potential alterations of autophagy and nuclear factor-B (NF-B) during anti-osteoclastogenic effects by ISL in vitro and in vivo. We observed that ISL inhibited the receptor activator of nuclear factor-B ligand (RANKL)-induced osteoclastogenesis and suppressed autophagic microtubule-associated protein light chain 3 (LC3)-II and Beclin 1 accumulation. ISL treatment resulted in the interruption of several specific features for autophagy in osteoclast precursors, including acidic vesicular organelle formation, LC3-II accumulation, and appearance of autophagic vacuoles. The RANKL-stimulated expression levels of autophagy-related genes and proteins also diminished in ISL-treated osteoclast precursors. The reactivation of autophagy by rapamycin almost reversed the ISL-elicited anti-osteoclastogenic effects. Interestingly, ISL inhibited the RANKL-stimulated NF-B expression and nuclear translocation, whereas the NF-B inhibitor Bay 11-7082markedly suppressed the RANKL-induced autophagic activation. Consistent with the in vitro results, the administration of ISL could attenuate osteoclastogenic cathepsin K, autophagic LC3, and NF-B expression to protect against inflammatory calvarial bone erosion in vivo. Our findings highlight theinhibition of NF-B-dependent autophagy as an important mechanism of ISL-mediated anti-osteoclastogenic activity.

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08:59

Isoliquiritigenin can be a promising therapeutic agent for the melanoma via reliving hypoxia of microenvironment. GreenMedInfo

PMID:  Recent Pat Anticancer Drug Discov. 2016 ;11(2):215-27. PMID: 26951491 Abstract Title:  Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells. Abstract:  BACKGROUND: Isoliquiritigenin (ISL) is a licorice chalcone. According to CN104758274, CN101658513 and US009089546, it is claimed that ISL has anti-inflammatory, anti-oxidative, and anti-tumoral effects.OBJECTIVE: This study aimed to investigate the potential therapeutic effect of ISL in mouse melanoma B16F10 cells.METHODS: Sulforhodamine B (SRB) colorimetric assay was used to test the effects of ISL on proliferation. Commercial assay kits were applied to assess glucose uptake, lactate production and ATP levels. Measurement of apoptosis was involved with Hoechst 33258, JC-1 and annexin V-FITC/PI staining. H2DCFDA probe was employed to detect ROS generation. Quantitative RT-PCR and western blot were utilized to measure the mRNA and protein levels.RESULTS: ISL abated hypoxia-inducible factor 1 (HIF-1) stability and reduced a series of glycolysis-relevant enzymes expression, including glucose transporters 1/4 (GLUT 1/4), hexokinase 2 (HK2), pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA). Exposure to ISL induced the mitochondrial membrane potential depolarization and increased intracellular reactive oxygen species (ROS) level. ISL could effectively inhibit proliferation and alleviate hypoxia in mouse melanoma B16F10 cells via inducing apoptosis and reducing the expression of significant enzymes in the glycolysis. ISL significantly inhibited B16F10 cell proliferationvia inducing apoptosis, and alleviated hypoxia by recovering mitochondrial function and reversing high glycolysis.CONCLUSION: Our findings propose that ISL can be a promising therapeutic agent for the melanoma via reliving hypoxia of microenvironment and targeting energy metabolism system of cancer cells. Consistent with WO2015079213 and WO2014084494, targeting glycolysis can be an effective means to anti-cancer.

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08:49

Holistic Doctor and Entire Family Found Shot Dead in Arizona Home Natural Blaze

Yet another holistic doctor has unfortunately passed away. The deaths of  Annie Fairbanks, husband Jason Fairbanks, both 39 years old, their 3-year-old daughter, and 9-month-old son are shocking the natural health community.

They were killed by apparent gunshot wounds which police were quick to rule a murder, suicide. Sergeant Ben Hoster of the Scottsdale, Arizona Police Department spoke on behalf of the department. He told the press within hours of the shooting that Jason Fairbanks must have killed his wife and two children before turning the gun on himself.

Some reporters that have been keeping track of holistic doctor deaths over the past two years claim that this is well over the 70th death of an alternative health activist, journalist, or doctor.

The circumstance in which these lives have been taken are often shrouded in mysterious circumstances or surrounded by friends and family who say the victims werent the type to take their own lives.

From AZ Central:

The two-story stucco home is in a quiet upper-middle-class neighborhood. Homemade art adorned one of the familys windows.

When Jason did not show up to work, a co-worker went to the home and discovered the bodies, Hoster said.

Hoster said the couple had been experi...

08:30

How To Lose 10 Pounds In A Week: 7 Day Diet Plan (Science-Based) Healthy and Natural World

It is possible to lose 10 pounds in just one week with an effective 7-day diet plan. Rapid weight loss in one week can help you kick-start a long-term diet plan if you need to lose weight for health reasons or to get rid of excess body weight. Usually, losing weight in 7 days will result in a loss of mostly water weight. However, this can help get your weight down quickly as you aim to shed body fat in the weeks and months following.

Any effective diet plan to lose extra body weight fast should include exercise programs to burn fat and lifestyle changes to help keep weight off. These lifestyle changes for quick weight loss will help you lose weight safely and for the long term. Your 7-day diet plan will help you learn good habits to use as you continue your weight-loss program.

Having the goal to lose 10lbs, 20lbs, or 30lbs in a short space of time is a good goal, especially as being overweight or obese has related health issues. However, losing such a lot of weight so quickly could also cause other unnecessary health complications. A 7-day diet plan to lose 10 pounds in a week will mostly result in losing water weight. After that, you should concentrate on making good choices to help lose body fat in a gradual, calculated way.

In this article, you will find a detailed, research based, and comprehensive diet plan to help you lose up to 10 pounds in a week. These science-based methods will help you lose weight fast and develop good habits to help you lose weight and keep it off.

Is It Possible to Lose 10 Pounds in One Week?

With an effective diet plan and exercising, it is really possible to lose 10 pounds in just one week.

To make sure you lose weight safely, its important that any diet plan whether that is a 7-day plan or a 30-day diet plan for rapid weight loss should not restrict nutrients that your body needs. Its good to remember that you didnt gain 10lbs in 7 days and its not reasonable to assume that you can lose 10lbs of pure body fat in 7 days.

So, how is it possible to lose 10 pounds in one week? According to a study published in the American Journal of Clinical Nutrition, most of the initial weight that a person loses by reducing calorie intake is water weight.

Researchers say that glycogen is the storage form of carbohydrates in your body which requires water to be stored by the body. When you start on a diet to restrict calorie intake, your body weight reduces because of glycogen stores and water being depleted.1

The study fo...

08:16

55 Organizations Representing 5 Million Serve Legal Notice to HHS for Failure to Conduct Vaccine Safety Tests: Civil Action to Follow? Health Impact News

sb277-opposition

The public turned out in mass in California in 2015 to oppose SB277 which removed parental rights to refuse vaccines based on religious or philosophical objections.

by Christina England
Health Impact News

Each time a parent decides to have their child vaccinated, they do so believing that each vaccine has been rigorously tested for vaccine safety and efficacy. Equally, they are of the understanding that their child will be protected from deadly diseases once they have received the vaccine.

In reality, however, vaccines are not being tested for safety before entering the market. This is because the creation of the 1986 National Vaccine Injury Compensation Program took all liability away from the pharmaceutical industry and transferred it to the health department. Due to these actions, it is now the responsibility of the U.S. Department of Health and Human Services to conduct all the safety testing that the pharmaceutical industry no longer has to do.

Mr. Del Bigtree, producer of the film VAXXED which chronicles the revelations of a CDC whistleblower who revealed that data showing a vaccine-autism connection was covered up, stated on camera that:

We believe that there is a major failure of Health and Human Services (HHS) to do the appropriate safety tests.

Angered by what he believes to be the lack of science and appropriate testing being carried out by the HHS, Mr. Bigtree and the Informed Consent Action Network (ICAN), supported by 55 organizations representing over 5 million people, have taken the unprecedented step of serving a notice to Mr. Don Wright, M.D., M.P.H., who is the acting secretary of the HHS department, demanding action to be taken.

This notice, served on October 12, 2017, outlined exactly how the HHS department had failed in thei...

08:01

55 Organizations Representing 5 Million Serve Legal Notice to HHS for Failure to Conduct Vaccine Safety Tests: Civil Action to Follow? Vaccine Impact

sb277-opposition

The public turned out in mass in California in 2015 to oppose SB277 which removed parental rights to refuse vaccines based on religious or philosophical objections.

by Christina England
Health Impact News

Each time a parent decides to have their child vaccinated, they do so believing that each vaccine has been rigorously tested for vaccine safety and efficacy. Equally, they are of the understanding that their child will be protected from deadly diseases once they have received the vaccine.

In reality, however, vaccines are not being tested for safety before entering the market. This is because the creation of the 1986 National Vaccine Injury Compensation Program took all liability away from the pharmaceutical industry and transferred it to the health department. Due to these actions, it is now the responsibility of the U.S. Department of Health and Human Services to conduct all the safety testing that the pharmaceutical industry no longer has to do.

Mr. Del Bigtree, producer of the film VAXXED which chronicles the revelations of a CDC whistleblower who revealed that data showing a vaccine-autism connection was covered up, stated on camera that:

We believe that there is a major failure of Health and Human Services (HHS) to do the appropriate safety tests.

Angered by what he believes to be the lack of science and appropriate testing being carried out by the HHS, Mr. Bigtree and the Informed Consent Action Network (ICAN), supported by 55 organizations representing over 5 million people, have taken the unprecedented step of serving a notice to Mr. Don Wright, M.D., M.P.H., who is the acting secretary of the HHS department, demanding action to be taken.

This notice, served on October 12, 2017, outlined exactly how the HHS department had failed in their d...

08:00

Dr Ron Unfiltered Uncensored Dr Bennet Omalu Guest Dr Ron Unfiltered Uncensored

Bennet Omalu Bennet Ifeakandu Omalu is a Nigerian American physician, forensic pathologist, and neuropathologist who was the first to discover and publish findings of chronic traumatic encephalopathy in American football players while working at the Allegheny County Coroner's Office in Pittsburgh. Bennet Omalu discovered Chronic Traumatic Encephalopathy in former football players, sparking years of denial from the NFL and the creation of a movie about his life's work. For Omalu, the release of Concussion served as the ultimate vindication for years of hard work, and provided a spotlight for other endeavors. Along with his position as chief medical examiner for San Joaquin County, he serves as president of Bennet Omalu Pathology, as well as associate clinical professor of pathology at UC Davis Medical Center. Omalu has a new book, Truth Doesnt Have a Side. The book further details the link between football, CTE and other diseases caused by brain trauma.

07:55

Deforestation Causing Extreme Summers Around the World Natural Blaze

By Brandon TurbevilleNatural Blaze

Despite all the scandals and hysteria, it appears that humans are indeed causing climate change. However, it is not because of lawnmowers, driving, or having the audacity to keep their houses at a comfortable temperature; nor does it have anything to do with human-produced Co2.

One significant danger to the Earth, long known to many legitimate environmentalists who did not get sidetracked by Al Gore and the Club of Rome, is deforestation.

Data released last week by NOAA shows that deforestation is having a significant effect on both the temperature or overall precipitation of the impacted regions. In some regions, deforestation doubled and even quadrupled the frequency of hot, dry summers.

The most extreme readings tended to be found in North America and Europe. NOAA used land surface and atmospheric models to determine the link between deforestation and extreme summers.

Here, the science is simple enough: in places where trees are being cut down en masse, there is less shade and less evaporative coolin...

07:35

Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis. GreenMedInfo

PMID:  Sci Rep. 2016 Mar 15 ;6:23097. Epub 2016 Mar 15. PMID: 26975571 Abstract Title:  Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. Abstract:  Isoliquiritigenin (ILG) is a flavonoid derived from Glycyrrhiza uralensis and potently suppresses NLRP3 inflammasome activation resulting in the improvement of diet-induced adipose tissue inflammation. However, whether ILG affects other pathways besides the inflammasome in adipose tissue inflammation is unknown. We here show that ILG suppresses adipose tissue inflammation by affecting the paracrine loop containing saturated fatty acids and TNF- by using a co-culture composed of adipocytes and macrophages. ILG suppressed inflammatory changes induced by the co-culture through inhibition of NF-B activation. This effect was independent of either inhibition of inflammasome activation or activation of peroxisome proliferator-activated receptor-. Moreover, ILG suppressed TNF--induced activation of adipocytes, coincident with inhibition of IB phosphorylation. Additionally, TNF--mediated inhibition of Akt phosphorylation under insulin signaling was alleviated by ILG in adipocytes. ILG suppressed palmitic acid-induced activationof macrophages, with decreasing the level of phosphorylated Jnk expression. Intriguingly, ILG improved high fat diet-induced fibrosis in adipose tissue in vivo. Finally, ILG inhibited TLR4- or Mincle-stimulated expression of fibrosis-related genes in stromal vascular fraction from obese adipose tissue and macrophages in vitro. Thus, ILG can suppress adipose tissue inflammation by both inflammasome-dependent and -independent manners and attenuate adipose tissue fibrosis by targeting innate immune sensors.

read more

07:22

These results suggest that Isoliquiritigenin may be beneficial for the treatment of mucosal inflammation. GreenMedInfo

PMID:  Arch Pharm Res. 2016 Oct ;39(10):1465-1471. Epub 2016 Aug 18. PMID: 27539609 Abstract Title:  Isoliquiritigenin suppresses tumor necrosis factor--induced inflammation via peroxisome proliferator-activated receptor- in intestinal epithelial cells. Abstract:  Intestinal epithelial cells play an important role in the mucosal immune reaction in inflammatory bowel diseases via the expression of inflammatory mediators, such as cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1). Isoliquiritigenin (ISL; 4,2',4'-trihydroxychalcone) has been shown to exhibit anti-inflammatory properties in murine macrophage cells. In the present study, we evaluated the anti-inflammatory properties of ISL in intestinal epithelial cells and determined its mechanism of action. ISL suppressed the expression of COX-2 and ICAM-1 in tumor necrosis factor- (TNF-) stimulated intestinal epithelium HT-29 cells. It also induced peroxisome proliferator-activated receptor- (PPAR) protein expression. Moreover, using a PPAR antagonist, GW9662, we found that the regulation of COX-2 and ICAM-1 expression by ISL in TNF--stimulated HT-29 cells is mediated via PPAR expression. A signal transduction study revealed that ISL significantly attenuates TNF--mediated JNK phosphorylation. ISL-induced ERK1/2 phosphorylation was associated with PPAR expression. Additionally, both the inhibitory effect on COX-2 and ICAM-1 expression and the inductionof PPAR expression by ISL in TNF--stimulated HT-29 cells was abolished by the addition of U0126, a specific ERK1/2 inhibitor. Collectively, ISL-induced PPAR mediated, at least partially, the suppression of intestinal inflammation. These results suggest that ISL may be beneficial for the treatment of mucosal inflammation.

read more

07:12

Red propolis can be a potential alternative therapeutic treatment against Chagas disease and some types of cancer. GreenMedInfo

PMID:  PLoS One. 2017 ;12(3):e0172585. Epub 2017 Mar 30. PMID: 28358806 Abstract Title:  Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. Abstract:  Propolis is known for its biological properties and its preparations have been continuously investigated in an attempt to solve the problem of their standardization, an issue that limits the use of propolis in food and pharmaceutical industries. The aim of this study was to evaluate in vitro antioxidant, antimicrobial, antiparasitic, and cytotoxic effects of extracts of red, green, and brown propolis from different regions of Brazil, obtained by ethanolic and supercritical extraction methods. We found that propolis extracts obtained by both these methods showed concentration-dependent antioxidant activity. The extracts obtained by ethanolic extraction showed higher antioxidant activity than that shown by the extracts obtained by supercritical extraction. Ethanolic extracts of red propolis exhibited up to 98% of the maximum antioxidant activity at the highest extract concentration. Red propolis extracts obtained by ethanolic and supercritical methods showed the highest levels of antimicrobial activity against several bacteria. Most extracts demonstrated antimicrobial activity against Staphylococcus aureus. None of the extracts analyzed showed activity against Escherichia coli or Candida albicans. An inhibitory effect of all tested ethanolic extracts on the growth of Trypanosoma cruzi Y strain epimastigotes was observed in the first 24 h. However, after 96 h, a persistent inhibitory effect was detected only for red propolis samples. Only ethanolic extracts of red propolis samples R01Et.B2 and R02Et.B2 showed a cytotoxic effect against all four cancer cell lines tested (HL-60, HCT-116, OVCAR-8, and SF-295), indicating that red propolis extracts have great cytotoxic potential. The biological effects of ethanolic extracts of red propolis revealed in the present study suggest that red propolis can be a potential alternative therapeutic treatment against Chagas disease and some types of cancer, although high activity of red propolis in vitro needs to be confirmed by future in vivo investigations.

read more

07:11

Fluoride petition circulates Edgartown Fluoride Action Network

The Edgartown board of healths decision to add fluoride to the town water supply has sparked outrage from the community.

It should have been brought before the voters, and not been done behind closed doors, Water commission superintendent Bill Chapman said in a phone conversation with The Times.

On Oct. 10, board of health members Harold Zadeh and Dr. Garrett Orazem voted in favor of adding fluoride, and Kathie Case abstained. According to Massachusetts general law, 10 percent of the 3,628 registered voters must petition the boards decision in less than 90 days, otherwise fluoride will be added to the water supply. The town has until mid-January.

In my opinion, said Edgartown resident Heidi Boyd, It doesnt seem fair that two people on the board of health made this decision for the whole town of Edgartown. I looked back at the minutes from the meeting, and the fluoride talk began in February, and we, the townspeople, are now just finding out about it in November. I work in the town hall, and I didnt hear a peep. Its an enormous decision and we should have a say.

The petition is active, and concerned residents are trying to spread the word. Last Saturday, Nov. 11, David and Megan Burke helped organize a drive-through petition signing.

Its tough, Mr. Burke said. A good portion of registered voters are snowbirds and leave the area. Its also been on public record that less than 10 percent of registered voters show up at town meeting. Its going to be difficult to obtain these signatures.

Petitioners are expected to be outside Tuesdays regularly scheduled water commissioners meeting at 3 pm. The board of health and the water department are scheduled to discuss their positions on fluoridation.

 

07:08

Studies Show That Husbands Stress Women Twice As Much As Children Healthy Holistic Living

A middle-aged man jokes with his work friends, saying, I love being a dad- I have 2 great kids. but my wife has 3! The group might laugh and allow the conversation to move on, but the truth is, many women today really do feel like theyre left to parent their partners instead of relying... View Article

The post Studies Show That Husbands Stress Women Twice As Much As Children appeared first on Healthy Holistic Living.

06:55

Study Shows: One Natural Practice Prevents SIDS in Over 60% of Cases. Yet No Country is Following These Guidelines AltHealthWorks.com

mother and healthy baby

PHOTO: Pixabay

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SIDs or sudden infant death syndrome is a devastating tragedy in the family: a perfectly healthy baby dying unexpectedly; and no scientist has so far being able to find a reason why. There are many theories that are being discussed, immunizations being one of them, but no conclusive answer has been discovered so far.

While the scientific community is looking for answers, SIDs continues to be the leading cause of deaths of children below the age of one; and every year, about 2,000 babies in the U.S. die from SIDS. In most cases, SIDS happens between the ages of two and four months.

What if many of these cases can be easily prevented?

A new study published in Pediatrics looked at over 2,200 SIDs cases and found out that it can be prevented in over half of the cases by doing what nature intended us to do breastfeeding.

Study: Reduce the Risk of SIDs by 64%

Scientists at the University of Auckland, New Zealand, examined 2,267 SIDs cases, along with 6,837 healthy babies, and found that SIDs can be prevented by breastfeeding alone.

By breastfeeding the baby for just two to four months, you may cut the risk of SIDs by 40%; for four to six months by 60%; and longer than 6 months by 64%.

The study also found that the amount of breastfeeding is irrelevant. Breast feeding can be supplemented by formula when needed, but researchers do encourage mothers to breastfeed exclusively for six months if possible.

Unfortunately, the United States has one of the lowest breastfeeding rates in the world, while New Zealand, the home of this study, has one of the highest.

But whether high or low rates, there is another guideline that not a single country in the world is following.

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Not a Single Country in The World Follows The WHO Guideline

The WHO confirms how important it is to breastfeed exclusively for the first six months, and with food supplementation for at least two years, and calls it a natural vac...

06:48

Red propolis fractions contain candidate agents for adjuvant cancer treatment. GreenMedInfo

PMID:  Biomed Pharmacother. 2017 Jul ;91:951-963. Epub 2017 May 13. PMID: 28514834 Abstract Title:  Antitumor activity of Brazilian red propolis fractions against Hep-2 cancer cell line. Abstract:  Continuous increases in the rates of tumor diseases have highlighted the need for identification of novel and inexpensive antitumor agents from natural sources. In this study, we investigated the effects of enriched fraction from hydroalcoholic Brazilian red propolis extract against Hep-2 cancer cell line. Initially 201 fractions were arranged in 12 groups according to their chromatographic characteristics (A-L). After an in vitro cell viability screening, J and L were further selected as promising enriched fractions for this study. The chemical characterization was performed and Biochanin A, Formononetin, and Liquiritigenin compounds were quantified. Through MTT viability assay and morphological changes observed by Giemsa and DAPI staining, the results showed that red propolis inhibited cancer cells growth. Flow cytometry results indicated effects that were partly mediated through programmed cell death as confirmed by externalization of phosphatidylserine, DNA cleaved assay, increase at SUB G1-G0 phase in cell cycle analysis and loss of mitochondrial membrane potential. In conclusion, our results demonstrated that red propolis enriched fractions promoted apoptotic effects in human cancer cells through the mechanisms involving mitochondrial perturbation. Therefore, red propolis fractions contain candidate agents for adjuvant cancer treatment, which further studies should elucidate the comprehensive mechanistic pathways.

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06:38

Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. GreenMedInfo

PMID:  Toxicol Appl Pharmacol. 2016 Dec 15 ;313:204-214. Epub 2016 Oct 3. PMID: 27702603 Abstract Title:  Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. Abstract:  The plant flavonoid isoliquiritigenin (ISL) is a botanical estrogen widely taken as an herbal supplement to ease the symptoms of menopause. ISL has been also shown to have anti-tumor properties in a number of cancer cell backgrounds. However, the effects of ISL on normal cells are less well known and virtually unstudied in the context of the pituitary gland. We have established a pituitary explant culture model to screen chemical agents for gene expression changes within the pituitary gland during a period of active proliferation and differentiation. Using this whole-organ culture system we found ISL to be weakly estrogenic based on its ability to induce Cckar mRNA expression, an estrogen receptor (ER) mediated gene. Using a range of ISL from 200nM to 200M, we discovered that ISL promoted cell proliferation at a low concentration, yet potently inhibited proliferation at the highest concentration. ICI 182,780 failed to antagonize ISL's repression of pituitary cell proliferation, indicating the effect is independent of ER signaling. Coincident witha decrease in proliferating cells, we observed down-regulation of transcript for cyclin D2 and E2 and a strong induction of mRNA and protein for the cyclin dependent kinase inhibitor Cdkn1a (p21). Importantly, high dose ISL did not alter the balance of progenitor vs. differentiated cell types withinthe pituitary explants and they seemed otherwise healthy; however, TUNEL staining revealed an increase in apoptotic cell death in ISL treated cultures. Our results merit further examination of ISL as an anti-tumor agent in the pituitary gland.

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06:35

Holistic Doctor and Entire Family Found Shot Dead in Arizona Home REALfarmacy.com

Source: Holistic Doctor and Entire Family Found Shot Dead in Arizona Home For more content like this visit REALfarmacy.com.

Yet another holistic doctor has unfortunately passed away. The deaths of  Annie Fairbanks, husband Jason Fairbanks, both 39 years old, their 3-year-old daughter, and 9-month-old son are shocking the natural health community. They were killed by apparent gunshot wounds which police were quick to rule a murder, suicide. Sergeant Ben Hoster of the Scottsdale, Arizona Police Department []

Source: Holistic Doctor and Entire Family Found Shot Dead in Arizona Home Learn more at REALfarmacy.com - Healthy News and Information.

05:43

The season in which propolis and its botanical source are collected influences its chemical compositions and antibacterial activity. GreenMedInfo

PMID:  Nat Prod Res. 2017 Jun ;31(11):1318-1324. Epub 2016 Oct 4. PMID: 27701899 Abstract Title:  The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. Abstract:  The aim of this study was to evaluate the effect of seasons on the chemical composition and antibacterial activity of Brazilian red propolis (BRP) and its plant source. BRP was collected from Maceio, Alagoas state, north-east of Brazil, during one year. Chemical composition was determined by physicochemical analyses and HPLC while antimicrobial activity was assessed against Streptococcus mutans, Streptococcus sobrinus, Staphylococcus aureus and Actinomyces naeslundii by determining the minimal inhibitory and bactericidal concentrations (MIC and MBC, respectively). The comparative chemical profiles varied quantitatively according to the collection period. Formononetin was the most abundant compound in both propolis and resin, while isoliquiritigenin, (3S)-neovestitol, (3S)-vestitol are suggested to be responsible for antimicrobial activity of Brazilian red propolis. MIC varied from 15.6 to 125 g/mL, whereas MBC varied from 31.2 to 500 g/mL. Therefore, season in which propolis and its botanical source are collected indeed influences their chemical compositions, resulting in variations in their antibacterial activity.

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05:25

Both quercetin and isoliquiritigenin exhibited anti-cancer effects on Epstein-Barr virus associated gastric carcinoma. GreenMedInfo

PMID:  Molecules. 2016 Sep 26 ;21(10). Epub 2016 Sep 26. PMID: 27681719 Abstract Title:  Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma. Abstract:  Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The flavonoids in licorice are known to have strong anti-cancer activities. Quercetin, the most abundant flavonoid, has been shown to have anti-ulcer, anti-cancer, antioxidant, and anti-inflammatory properties. Latent Epstein-Barr virus (EBV) infection can lead to serious malignancies, such as, Burkitt's lymphoma, Hodgkin's disease and gastric carcinoma(GC), and (Epstein-Barr virus associated gastric carcinoma) EBVaGC is one of the most common EBV-associated cancers. In this study, the authors first examined the anti-cancer effects of quercetin and isoliquiritigenin in vivo xenograft animal models implanted with EBV(+) human gastric carcinoma (SNU719) or EBV(-) human gastric carcinoma (MKN74), and then explored the molecular mechanisms responsible for their anti-cancer activities. The results obtained showed that anti-cancer effect of quercetin was greater than isoliquiritigenin in mice injected with EBV(+) human gastric carcinoma (SNU719) cells. On the other hand, quercetin and isoliquiritigenin had similar anti-cancer effects in mice injected with EBV(-) human gastric carcinoma (MKN74) cells. Interestingly, quercetin inhibited EBV viral protein expressions, including EBNA-1 and LMP-2 proteins in tumor tissues from mice injected with EBV(+) human gastric carcinoma. Quercetin more effectively induced p53-dependent apoptosis than isoliquiritigenin in EBV(+) human gastric carcinoma, and this induction was correlated with increased expressions of the cleaved forms of caspase-3, -9, and Parp. In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.

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05:08

This 12 Year Old Girl Could Cause Cannabis to Be Legalized Nationwide REALfarmacy.com

Source: This 12 Year Old Girl Could Cause Cannabis to Be Legalized Nationwide For more content like this visit REALfarmacy.com.

by CAREY WEDLER A twelve-year-old girl with epilepsy is suing Attorney General Jeff Sessions, the Department of Justice, and the Drug Enforcement Agency to legalize cannabis across the country. Alexis Bortell developed epilepsy at the age of seven, and FDA-approved medications failed to improve her condition. She suffered from multiple seizures per day, and doctors were considering []

Source: This 12 Year Old Girl Could Cause Cannabis to Be Legalized Nationwide Learn more at REALfarmacy.com - Healthy News and Information.

05:08

Campaign to Restore Child Health: Vaccines in Pregnancy Not Tested for Safety World Mercury Project

In recent years the CDC has made recommendations that women receive flu vaccines and TDaP vaccines during their pregnancy even though the package inserts state there are no long term safety studies to justify this practice. Mothers are reporting miscarriage, pre-term labor and health issues for themselves and their children following these vaccines. A recent CDC study found that pregnant women vaccinated with the influenza vaccine had 2 times greater odds of miscarrying their babies compared to women who did not receive flu vaccine. Heres one mothers story of her twins after a flu vaccine in pregnancy. Share your story and hashtag it #restorechildhealth #worldmercuryproject.

Also watch Robert F. Kennedy, Jr. launch the Campaign to Restore Child Health

The post Campaign to Restore Child Health: Vaccines in Pregnancy Not Tested for Safety appeared first on World Mercury Project.

04:41

5 Seasonal Flu Vaccine Myths Debunked Natural Blaze

Flu Vaccine Myths

By Phillip Schneider

Its flu season again, which means its time to see an unavoidable barrage of stories in the corporate media claiming that vaccines are entirely safe, effective and without consequence. Were told that vaccines are harmless and there will be no consequences for trusting the medical establishment, but is this really the case? Of course, some vaccines have aided humanity since their inception, but others have done a great deal of damage, particularly the flu shot.

This article from People magazine is a good example of vaccine propaganda with no regard to showcasing the health dangers, toxic ingredients, or cases of vaccine-related deaths and illnesses. In the spirit of full disclosure, Ill be going over their major points and telling the side of the story that vaccine manufacturers and media moguls dont want you to hear.

   SEE: Try Natures Flu Shot!

 

1. The Myth That Vaccines Cause the Flu

The common argument among vaccine proponents is that due to the inactive state of the virus in the vaccine, which is brought about by wea...

03:15

3 Troubling Signs of the Expanding War on Childrens Health Natural Blaze

By Alex Pietrowski

There are some disturbing trends developing in childrens welfare, tell-tale signs of which are emerging from mainstream media sources. Its an assault on the health, sovereignty and well-being of our children. If youve ever wondered why people are so much more insane today than they used to be, theres a real chance it could be because of the things we are doing to kids these days.

Robbing Children and Their Parents of Health Sovereignty

For decades now, American municipalities have been fluoridating public water supplies, a practice which may very well be considered medication without consent, a violation of basic human rights. This is particularly more serious for children, as their small bodies receive much higher relative doses than adults. Even the government has had to admit that fluoridation is not as beneficial for teeth as weve been told,  and studies are demonstrating that exposure to fluoride may be damaging to developing of child intelligence, causing lower IQ.

Beyond fluoridation, parents are increasingly being superseded by the government when making health decisions for their children. This is happening with regards to vaccination, as one mother was recently jailed for choosing not to vaccinate her child, and while in police custody the state administered vaccines without parental consent. Major illnesses like cancer are also now grounds for state health tyranny. In 2016, Cassie C, a teenager from Connecticut was forced to undergo chemotherapy even though her and here parents had decided against it.

...

03:00

The phantom reference: How a made-up article got almost 400 citations Retraction Watch

Heres a mystery: How did a nonexistent paper rack up hundreds of citations? Pieter Kroonenberg, an emeritus professor of statistics at Leiden University in The Netherlands, was puzzled when he tried to locate a paper about academic writing and discovered the article didnt exist. In fact, the journalJournal of Science Communicationsalso didnt exist. Perhaps Kroonenbergs []

The post The phantom reference: How a made-up article got almost 400 citations appeared first on Retraction Watch.

02:46

Rankin Inlets rickety water infrastructure raises worries Fluoride Action Network

The shoddy shape of Rankin Inlets water treatment and distribution system poses many health and safety risks that must be addressed in the near future, warns a Government of Nunavut report.

Thats from a request for proposals issued Nov. 10 by the territorial government, which is seeking ideas for how best to replace the aging water treatment and distribution infrastructure that supports the Kivalliq community of about 2,850 people.

Risks identified by the report include:

Rankin Inlets water storage tank was originally designed to hold one weeks worth of water when it was built in the 1970s. But, due to the communitys growth, its now only able to hold a two-day supply. If a problem were to occur with the upstream pump house or pipeline, the report warns it does not allow a lot of time for repair before the town runs out of water.

In 2015, Rankin Inlet faced a precautionary boil-water advisory for two weeks, after tests showed drinking water wasnt being adequately treated with chlorine. As a stop-gap solution, the raw water storage tank was converted into a treated water storage tank, but the report says thats no substitute for a properly built system for treating water, possibly including a second stage of disinfection.

Due to a faulty design, one of the communitys water distribution lines suffers from water pressure thats so low, it may not be able to support firefighting.

Theres no gas monitoring at the water treatment plant, as required when working with chemicals like chlorine and fluoride. Inadequate ventilation has resulted in the fluoridation system being taken offline.

 Electrical wiring isnt up to code. Most notably, it is not grounded, which is a major safety concern.

 Asbestos has been found inside one pump house.

Rankin Inlets water treatment system is over 40 years old and is showing its age, the report states. The design of the system does not meet current codes and standards, nor does it meet the current and future water needs of the Hamlet.

Chief among the reports structural concerns is the state of the Williamson Lake Pump House, which it calls the heart of the system. Built in the 1970s, the pump house has reached the end of its serviceable life, the report states. Problems include:

The buildings pipes are corroded and, in some cases, partially plugged by build-up.

Storage tanks beneath the pump house have in some cases up to one inch of corrosion, and a ladder has completely detached as a result.

Valves in the plant dont work properly, so some areas cant be shut off for maintenance.

The concrete housing for the supply pumps is brittle and is at risk of complete failure...

00:21

Parents Blame Vaccines For Two Infants Deaths Vaxxter

Two infants from the region of Barangay Pajac, Lapu-Lapu City have passed away as of a few days ago. The parents have filed a complaint which asserts that vaccines were the mutual cause of deaths. The pentavalent...

The post Parents Blame Vaccines For Two Infants Deaths appeared first on Vaxxter.

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Tuesday, 14 November

22:20

Yerba Mate Enhances Cellular Energy and Metabolism PreventDisease.com

In South America, Yerba Mate has been grown and taken medicinally for centuries. Researchers have shown that use of the herb over an extended period had significant effects on body weight and weight gain and was associated with lower levels of blood lipids and insulin in obese mice fed a high-fat diet.

09:52

Black Seed Reverses Liver Disease GreenMedInfo

A new study on a widely revered herbal medicine has produced a potential breakthrough in treating a condition that is a warning sign of serious disease risks. This common health problem affects as many as 90 million Americans, most of whom dont even know they are in danger.

read more

Monday, 13 November

23:52

Delta Dental operates in 15 states to expand fluoridation including CA, NY, GA, PA Fluoride Action Network

Fluoridation Initiatives

Nearly all tooth decay can be prevented when fluoridation is combined with dental sealants and other fluoride products, such as toothpaste.

Why is water fluoridation so important? People living in communities with fluoridated drinking water experience 15 to 40 percent less tooth decay than those without fluoridation. Fluoride is absorbed by the gastrointestinal tract and distributed by the bloodstream to the bones and hard tissues of the teeth, making them less susceptible to decay.

The American Dental Association and the Centers for Disease Control and Prevention (CDC) in 2015 celebrated the 70th anniversary of community water fluoridation in the United States a development the CDC refers to as the single most cost-effective public health measure of the 20th century.

Delta Dentals Involvement

Seventy percent of all Americans have the benefit of fluoridated water. However, there are still many states with limited public access to fluoridated water.

Delta Dentals involvement in fluoridation advocacy has improved this picture. Weve been active in the California community water fluoridation effort as a member of the California Fluoridation Advisory Council, playing a part in an effort that resulted in an expansion of fluoridation to 18 million residents in southern California who receive water from the Metropolitan Water District.

The CFAC is a public-private partnership includes the California Department of Health Services, the California Dental Association, the Dental Health Foundation and several other interested agencies.

Weve hosted the nations first national fluoridation summit, sponsored a subsequent fluoridation summit offered by the American Dental Association, participated in trainings of oral health advocates on effective fluoridation advocacy in Albany, New York and Atlanta, Georgia, and supported legislation in Pennsylvania to expand fluoridation.

Wherever there is opportunity in Delta Dentals 15-state operating area, Delta Dental is ready to lend a hand to expand this most important public health measure.

What is Fluoride?

Fluoride is a compound of the element fluorine, naturally present in water, soil, air and many foods.

Fluoride absorbs easily into tooth enamel, especially in childrens growing teeth. As teeth develop, fluoride makes the entire tooth structure more resistant to decay.

Public water fluoridation is considered the most efficient and cost-effective way to prevent cavities, but other sources of fluoridation are important; many states or counties still dont have fluoridated tap water. (You may check with your local water department for more current numbers.)

Another reason to be concerned about intake of fluoridated water is that people are drinking more bottled water, which contains minimal amounts of fl...

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