IndyWatch Health Watch Feed Archiver

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

IndyWatch Health Watch Feed was generated at Community Resources IndyWatch.

Monday, 16 July

00:15

Richard Pan To Propose Heavier Mandatory Vaccine Enforcements As Outbreak Vulnerability Rises Vaxxter

California is notoriously tough on the issue of vaccines. It has been two years since the state enacted draconian mandatory vaccine laws, pushing vaccine rates to the record levels. However, even though by some accounts...

The post Richard Pan To Propose Heavier Mandatory Vaccine Enforcements As Outbreak Vulnerability Rises appeared first on Vaxxter.

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Sunday, 15 July

21:56

Flutemetamol F 18. Summary of Use during Lactation. Fluoride Action Network

Drug Levels and Effects

Information in this record refers to the use of flutemetamol F 18 as a diagnostic agent. No information is available on the use of flutemetamol F 18 during breastfeeding. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose of 185 MBq (5 mCi). This length of time is about 10 half-lives of fluoride F 18 and less than 0.01% of the radioactivity administered will remain in the body. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1][2][3]

Drug Levels

Fluoride F18 decays by positron emission with a physical half-life of 109.7 minutes.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1 Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www?.nrc.gov/reading-rm?/doc-collections?/nuregs/staff/sr1556/v9/r2/

2 Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: data, quantitative analysis and recommendations. Nucl Med Commun. 1989;10:15-27. [PubMed]

3 Early PJ, Sodee DB. Principles and practice of nuclear medicine. 2nd ed. St. Louis. Mosby-Year Book, Inc. 1995:1380-1.

Substance Identification

Substance Name: Flutemetamol F 18

CAS Registry Number: 765922-62-1

Drug Class

  • Radi...

21:44

Florbetaben F 18: Summary of Use during Lactation. Fluoride Action Network

Drug Levels and Effects

Information in this record refers to the use of florbetaben F 18 as a diagnostic agent. No information is available on the use of florbetaben F 18 during breastfeeding. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose Twenty-four hours is about 10 half-lives of fluoride F 18 and less than 0.01% of the radioactivity administered will remain in the body. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1][2][3]

Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[4]

Drug Levels

Fluoride F18 decays by positron emission with a physical half-life of 109.7 minutes.

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1 Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www?.nrc.gov/reading-rm?/doc-collections?/nuregs/staff/sr1556/v9/r2/

2 Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: data, quantitative analysis and recommendations. Nucl Med Commun. 1989;10:15-27. [PubMed]

3 Early PJ, Sodee DB. Principles and practice of nuclear medicine. 2nd ed. St. Louis. Mosby-Year Book, Inc. 1995:1380-1.

4 Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000;41:863-73. [...

21:27

Sodium Fluoride F 18: Summary of Use during Lactation. Fluoride Action Network

Drug Levels and Effects

Information in this record refers to the use of sodium fluoride F 18 as a diagnostic agent. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose of 300-450 MBq (8 to 12 mCi); however, this time might be longer than necessary given the minimal amount of fluoride that appears in breastmilk. Twenty-four hours is about 10 half-lives of fluoride F 18 and less than 0.01% of the radioactivity administered will remain in the body. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1][2][3]

Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[4]

Drug Levels

Fluoride F18 decays by positron emission with a physical half-life of 109.7 minutes.

Maternal Levels. A study in one mother who received an oral dose of 25 mg of nonradioactive sodium fluoride found that milk fluoride concentrations closely paralleled maternal serum fluoride concentration at 21 to 32% of maternal serum levels over an 8-hour period. The authors estimated that this represents only 0.2% of the dose given to the mother.[5]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1 Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www?.nrc.gov/reading-rm?/doc-collections?/nuregs/staff/sr1556/v9/r2/

2 Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: data, quantitative analysis and recommendations. Nucl Med Commun. 1989;10:15-27. [...

20:46

Letter | Why doesnt Oberon have a full-time dentist? Fluoride Action Network

IN response to the pro-fluoride letter on June 28 by V Clark-Ferraino, the truth is that Colgate University and Manchester University have promoted fluoride products for over 40 years and they established the Cochrane Collaboration. Colgate provided infrastructure as well as academic salaries and prizes associated with the Trendley Dean Medal. Despite this, Cochrane Collaboration has found that fluoride toothpaste less than 1000 ppm and fluoride varnishes provide no benefit compared to non-fluoridated products. So how can 1 ppm in water passing through the mouth in a matter of seconds possibly help?

I repeat the Cochrane Fluoridation findings: There is very little contemporary evidence, meeting the reviews inclusion criteria, that has evaluated the effectiveness of water fluoridation for the prevention of caries. https://bit.ly/2LM85ph (2015). Colgate is now promoting fluoride-free toothpaste for children under six, and some of its competitors warn not to use fluoride for any child under 12.

Local proof that water fluoridation does not work comes from NSW public servants (thats correct, fluoride does not work. My apologies, its just that we obviously need repetition). Tamworth in NSW has been fluoridated for 55 years and is experiencing rampant tooth decay. This was the headline in The Land and The Northern Daily Leader: Rot is setting in tooth decay rife among Tamworth kids. Dental hygienist Mandy Sorensen said: There is definitely an increase in the decay rate and we do see some pretty nasty cases. A report released by Adelaide University found that 40 per cent of Tamworth children in primary school aged five to 10 years had decay in their baby teeth. (Haley Sheridan, May 2016).

To think Oberon does not have a full-time dentist. If we had such enormous decay rates as Bathurst dentists would have us believe, then our population numbers would require at least one full-time dentist, but we dont because there is not enough work.

The very same NSW Health people promoting fluoridation to Oberon in 2014, ie Dr Shanti Sivaneswaran, published a paper that basically says children in fluoridated areas had 1.5 times the damaged permanent teeth compared to non-fluoridated areas. Thats how crazy this gets. Their conclusion was: Gender, water fluoridation, Aboriginal status and parental education were not significant predictors of caries experience. (Zander et al 2013).

More good news for those against water fluoridation: last weeks NZ Supreme Court ruling, confirming the 1964 ruling of Justice Gillard in Victoria, that fluoride is mass-medicatio...

20:00

Autism Siblings: Taking it to the Next Level AGE OF AUTISM

By Cathy Jameson People warned me that the years go by quickly. Boy, were they right! Time really is flying by. Im reminded of that when Ronans big sister checks out a new college. Fionas been checking out colleges for...

15:00

Chiropractic BioPhysics and Gonstead Technique for Spinal Health Articles

By Dr. Mercola

Nearly two years ago, a good friend of mine, Dr. Peter Martone, a longtime chiropractor, pointed out I had some problems with my cervical spine. While I initially disagreed, X-rays revealed degeneration in my fifth and sixth cervical vertebrae, even though I had no symptoms at all.

In this interview, Dr. Michael Hill a graduate of Palmer College in Davenport, Iowa discusses Chiropractic BioPhysics (CBP) and Gonstead, a specific type of chiropractic treatment that addresses this kind of problem. Ive always been opposed to X-rays and dont recommend them. In this case, however, its necessary, as the treatment is precisely calibrated based on the X-ray data.

With chiropractic, one of the big components I like to really help patients understand is where all health and healing comes from, Hill says. We cant deny that the nervous system coordinates all function and healing in the body. If you dont know how to take care of it, whos going to do that for you and help you understand the importance behind it? Education is one of our biggest components in our office.

Chiropractic technique stands on three legs: the philosophy, science and art. If we take one away, its easy to tip over. Weve got to stay solid on those three components Gonstead and CBP have a lot in similarities, but a lot in differences. When it comes to understanding structure dictates function, your spine is basically the framework of everything else that works off of that.

Then its important to understand that we need to identify any structural changes that are compromising the way we should function. The intimate relationship between spine and nervous system is just that. Its intimate if we dont take care of the spine, the [nervous system] is going to fall short of 100 percent function.

Skeletal Structure and Function Influences Your Nervous System

A common assumption is that unless youre experiencing pain, all is well. In reality, many if not most diseases are asymptomatic until the disease process is well underway. As noted by Hill, theres research showing you have to lose 40 percent or greater of your health potential before any sign or symptom is expressed. So, its unfortunate that we are taught to treat and manage disease as opposed to preventing it.

One of the primary tools for maintaining health is to choose the right...

This Buffalo Coleslaw Is Perfect for Your Summer Cookouts Articles

Recipe From Ruled.me
Planning to throw a backyard barbeque party this summer? Take your BBQ to the next level by pairing it with this Buffalo Coleslaw from Ruled.me. Its creamy and crunchy, like a perfect coleslaw should be. But heres the twist: It also packs a spicy and tangy punch that will have you and your guests craving more. Its the perfect side dish to round out the rich flavors of your smoked and grilled meats. Its also quick and easy to make, so try to recreate this crowd-pleasing recipe today.


Ingredients:
1/4 cup mayonnaise
1/4 cup organic hot sauce
1/4 cup apple cider vinegar
1 teaspoon garlic powder
1/2 teaspoon salt
1/2 large green cabbage, thinly sliced
2 large ribs of celery, finely diced
1/2 medium-sized white onion, finely diced
2 tablespoons chopped chives
1 cup grass fed blue cheese, crumbled

Procedure:

  1. In a medium-sized bowl, whisk together the mayonnaise, hot sauce, apple cider vinegar, garlic powder and salt.
  2. In a large mixing bowl, toss together the green cabbage, celery, white onion, half the chives and half the blue cheese.
  3. Add the dressing to the cabbage and toss together.
  4. Serve the coleslaw with a drizzle of hot sauce, and the remaining chives and blue cheese sprinkled on top .

Cabbage Is Loaded With Many Beneficial Nutrients

Cabbage belongs to the cruciferous family of vegetables, along with broccoli, cauliflower and Brussels sprouts. Its known to have cancer-fighting properties, as it contains high amounts of powerful phytochemicals like carotenoids, sulforaphane and isothiocyanates, which may help reduce the production of cancer-related hormones, inhibit tumor growth, induce apoptosis and detoxify carcinogens.
Studies have shown that these compounds in cabbage not only help lower the risk for breast, prostate and colon cancers, but they also help reduce the levels of low-density lipoprotein (LDL) or bad cholesterol in the blood. , In addition, cabbage nourishes your body with many beneficial vitamins and minerals, including:


Thiamin

Calcium...

Introduction to Hypoglycemia Articles

Have you been feeling faint or under the weather after changing your diet, skipping a few meals or going for a few hours more at the gym? If so, theres a chance that youre hypoglycemic. Hypoglycemia is a fairly common condition, especially in the diabetic population, which entails a dramatic decrease in your blood sugar levels. It may cause you to feel dizzy, weak and confused. These articles will focus on what hypoglycemia is, the symptoms you should look out for, and how you can prevent episodes from happening again.

Is Hypoglycemia Dangerous?

For most people, glucose is your primary source of energy, making it one of the most important substances in the body. Unfortunately, there are instances when the body is not able to properly regulate glucose expenditure, exposing you to a variety of conditions, which include hypoglycemia. Relatively, hypoglycemia is not a dangerous condition, as long as you listen to what your body is trying to tell you.

However, there are instances when it may cause extreme complications, which may endanger your life and the lives of the people around you. Severe attacks of hypoglycemia, especially in undiagnosed or unregulated diabetics, may cause seizures, blackouts and fainting spells.1 If youre driving or walking to work, these unexpected blackouts and loss of all motor functions may cause fatal accidents, which may lead to fatal repercussions.2

What Are the Risk Factors for Hypoglycemia?

Like other diseases, certain people are more susceptible to hypoglycemia than others. The risk depends on various external and internal factors, some of which are rooted in their interference with the bodys insulin production and energy expenditure. If you think you may be suffering from hypoglycemia, here are some of the risk factors that you should be looking out for:

Diabetes. Diabetes patients suffer from a relatively higher risk of getting hypoglycemia because of their body's inability to regulate insulin and glucose. This condition is more common in Type 1 diabetes patients because of their dependence on synthetic insulin. When their blood sugar drops to a critical level, they are at high risk for insulin shock, a life-threatening complication of hypoglycemia.3

Increased physical activity. A sudden increase in physical activity, whether during exercise or work, depletes the sugar in the body. This heightens your risk of hypoglycemia, especially if f...

14:46

Mad in Asia: Towards Multiple Narratives for Inclusion Mad In America

An e-zine with the mission to contribute to changing the narrative about madness and mental distress in the Asia region has launched. Mad in Asia hopes to showcase narratives that are contextually relevant to the Asia region, with a focus on the human rights of persons with psychosocial disabilities.

We share the concerns that many activists and advocates around the world have about the dominance of the biomedical model in the understanding, treatment and care of people deemed mentally ill. Many of our countries still operate under the legacy of colonial institutions and legal frameworks set up to manage the mad. Meanwhile, new global movements have set out to create and replicate policies and institutions based on western psychiatry and clinical psychology. Even in the alternatives to psychiatry context, efforts to drive innovations developed in the global north into the global south have sometimes tended to replicate old colonial tendencies.

We believe there is no single all-encompassing way to challenge and change the current narratives and practices that marginalise the experiences of persons with psychosocial disabilities. Nor can it be articulated in terms of an opposition to biomedical psychiatry and its institutions alone. In many of our countries, institutional psychiatry/psychology does not exist, and violation of our rights and personhood takes place within our societies, immediate community spaces and families. Collective action involves a whole range of negotiations as well as the affirmation and validation of knowledge, experiences and skills emerging from and responsive to local contexts. What is required, then, are contextually relevant multiple narratives.

The alliance of persons with psychosocial disabilities and cross disability supporters, TCI Asia (Transforming Communities for Inclusion of Persons with Psychosocial Disabilities, Asia), has been at the forefront of this work in the Asia region. Mad in Asia works in partnership with TCI Asia, aligning our objectives to focus on the human rights and community inclusion of persons with psychosocial disabilities. To change the mental health narrative to one that critically engages with peoples lived experiences in our region, we believe that notions such as community, inclusion, rights, personhood, disability, society as well as madness, mental health and psychiatry need to be examined.

Mad in Asia is a space led by persons with psychosocial disabilities from Asian countries for negotiating and nurturing such narratives. We hope to do this in collaboration with our allies including cross disability activists, mental health workers, academics, social justice campaigners, family and community members, and anyone else interested in joining this online community for change. In doing this, we hope to disseminate the extensive knowledge (theories, investigations, actions...

06:16

Are There Optogenetics, Nano Biology And Blue Light Nexus Health Problems? Natural Blaze

By Catherine J. Frompovich

Optogenetics is something consumers using all types of high tech gadgets need to become fully informed about; the sooner, the better! Using any device that emits light, especially that known as blue light needs to be looked at and considered as a potential health hazard, according to emerging research.

Here are two explanations for Optogenetics:

A technique in neuroscience in which genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals. Optogenetics allows researchers to control how nerve cells communicate

Source: Online Dictionary

Optogenetics is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. Wikipedia [CJF emphases on both]

03:55

Geoengineering Watch Global Alert News, July 14, 2018, #153 Geoengineering Watch

uu7yhDane Wigington GeoengineeringWatch.org Will social media providers continue to ramp up their censorship until a totalitarian state prevails? How many in industrialized nation populations are willing to look beyond the power structure's orchestrated political theater of the absurd? How many are willing to face the wider horizon of what is unfolding around us? Will it take total unraveling of

03:35

In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum. GreenMedInfo

PMID:  Pak J Biol Sci. 2014 Feb 1 ;17(3):402-7. PMID: 24897795 Abstract Title:  In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum. Abstract:  The aim of the present study is conducted to evaluate the antioxidant potential and toxicity effect of polysaccharide-fucoidan from the brown seaweed Sargassum tenerrimum. Fucoidan-a sulphated polysaccharide contains fucose and sulphate as major compounds. Interestingly, various studies reported that the presence of sulphate content of the sample plays a significant role in pharmacological activities. In this study, fucoidan was fractionated by Ion exchange chromatography method and it major chemical constituent sulphate and fucose was determined by the biochemical methods. The toxicity effect of fucoidan was analyzed by the brine shrimp toxicity assay. Three fucoidan fractions (F1, F2 and F3) were obtained from Intact Fucoidan (IF) through anion-exchange column chromatography. In vitro antioxidant capability was analyzed by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radical scavenging and total antioxidant assays and intact fucoidan showed the maximum activity 83.66 +/- 0.35, 81.73 +/- 0.35% and 41.6 +/- 0.43 mg g(-1), respectively. The finding of the present study was confirmed that the antioxidant property of fucoidan was depending upon the sulphate content of the fraction and these studies proved that fucoidan have non toxicity effect. Hence, fucoidan have the scope of being used as natural antioxidants in treating many human diseases.

read more

02:48

Fucoidan is a -amylase inhibitor which is more effective than that of acarbose. GreenMedInfo

PMID:  Int J Biol Macromol. 2015 Nov ;81:644-7. Epub 2015 Sep 9. PMID: 26325676 Abstract Title:  Fucoidan - An-amylase inhibitor from Sargassum wightii with relevance to NIDDM. Abstract:  The present experiment was conducted to screen the-amylase inhibitory activity of fucoidan extracted from Sargassum wightii collected at the coastal area of Mandapam, Tamil Nadu, India. Fucoidan was extracted from the sporophyll of S. Wightii by ethanol and CaCl2 precipitation method. The average yield was 1.80.16% and the extracted fucoidan was found to contain 530.52% of fucose and 360.60% of sulphate. Structural elucidation (FT-IR and NMR) and in vitro -amylase activity of purified fucoidon were performed. Fucoidan at the concentration of 62.5, 125 and 250g exhibited 24.81, 62.50 and 99.24% inhibition against -amylase, respectively, in a dose dependent manner. Fucoidan from S. wightii also inhibits -glucosidase which clearly indicates dual inhibitory activity of the compound. The IC50 value against -amylase of fucoidan is found to be 103.83g which is more effective than that of acarbose (16mg).

read more

02:40

These findings provide basic molecular information on the effect of fucoidan on angiogenesis in the presence of FGF-2. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2014 Aug 8 ;450(4):1333-8. Epub 2014 Jul 5. PMID: 25003321 Abstract Title:  Fucoidan/FGF-2 induces angiogenesis through JNK- and p38-mediated activation of AKT/MMP-2 signalling. Abstract:  Angiogenesis is an important biological process in tissue development and repair. Fucoidan has previously been shown to potentiate in vitro tube formation in the presence of basic fibroblast growth factor (FGF-2). However, the underlying molecular mechanism remains largely unknown. This study was designed to investigate the action of fucoidan in angiogenesis in human umbilical vein endothelial cells (HUVECs) and to explore fucoidan-signalling pathways. First, we evaluated the effect of fucoidan on cell proliferation. Matrigel-based tube formation and wound healing assays were performed to investigate angiogenesis. Matrix metalloproteinase-2 (MMP-2) mRNA expression and activity levels were analysed by reverse transcription polymerase chain reaction (RT-PCR) and zymography, respectively. Additionally, phosphorylation of mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) was detected by Western blot. The results indicate that fucoidan treatment significantly increased cell proliferation in the presence of FGF-2. Moreover, compared to the effect of FGF-2 alone, fucoidan and FGF-2 had a greater effect on tube formation and cell migration, and this effect was found to be synergistic. Furthermore, fucoidan enhanced the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38, and AKT. MMP-2 activation was also significantly increased. Specific inhibitors of p38 (SB203580) and JNK (SP600125) inhibited tube formation and wound healing, while an ERK inhibitor (PD98059) did not. MMP-2 activation and AKT phosphorylation were also attenuated and associated with the suppression of p38 and JNK phosphorylation, but not with that of ERK. These results indicate that fucoidan, in the presence of FGF-2, induces angiogenesis through AKT/MMP-2 signalling by activating p38 and JNK. These findings provide basic molecular information on the effect of fucoidan on angiogenesis in the presence of FGF-2.

read more

02:32

Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. GreenMedInfo

PMID:  PLoS One. 2014 ;9(9):e108157. Epub 2014 Sep 18. PMID: 25232957 Abstract Title:  Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. Abstract:  BACKGROUND: Cancer metastasis is the main cause leading to disease recurrence and high mortality in cancer patients. Therefore, inhibiting metastasis process or killing metastatic cancer cells by inducing apoptosis is of clinical importance in improving cancer patient survival. Previous studies revealed that fucoidan, a fucose-rich polysaccharide isolated from marine brown alga, is a promising natural product with significant anti-cancer activity. However, little is known about the role of endoplasmic reticulum (ER) stress in fucoidan-induced cell apoptosis.PRINCIPAL FINDINGS: We reported that fucoidan treatment inhibits cell growth and induces apoptosis in cancer cells. Fucoidan treatments resulted in down-regulation of the glucose regulated protein 78 (GRP78) in the metastatic MDA-MB-231 breast cancer cells, and of the ER protein 29 (ERp29) in the metastatic HCT116 colon cancer cells. However, fucoidan treatment promoted ER Ca2+-dependent calmodulin-dependent kinase II (CaMKII) phosphorylation, Bcl-associated X protein (Bax) and caspase 12 expression in MDA-MB-231 cells, but not in HCT116 cells. In both types of cancer cells, fucoidan activated the phosphorylation of eukaryotic initiation factor 2 alpha (p-eIF2)\CCAAT/enhancer binding protein homologous protein (CHOP) pro-apoptotic cascade and inhibited the phosphorylation of inositol-requiring kinase 1 (p-IRE-1)\X-box binding proteins 1 splicing (XBP-1s) pro-survival cascade. Furthermore, CHOP knockdown prevented DNA damage and cell death induced by fucoidan.CONCLUSION/SIGNIFICANCE: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its anti-tumour activity and provides evidence for the therapeutic application of fucoidan in cancer.

read more

02:11

Fucoidan may be considered for use in improving obesity. GreenMedInfo

PMID:  Phytother Res. 2014 Jan ;28(1):137-43. Epub 2013 Apr 12. PMID: 23580241 Abstract Title:  Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation. Abstract:  This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity.

read more

02:07

A review of fucoidan as a marine anticancer agent in preclinical development. GreenMedInfo

PMID:  Mar Drugs. 2014 Jan 28 ;12(2):851-70. Epub 2014 Jan 28. PMID: 24477286 Abstract Title:  Fucoidan as a marine anticancer agent in preclinical development. Abstract:  Fucoidan is a fucose-containing sulfated polysaccharide derived from brown seaweeds, crude extracts of which are commercially available as nutritional supplements. Recent studies have demonstrated antiproliferative, antiangiogenic, and anticancer properties of fucoidan in vitro. Accordingly, the anticancer effects of fucoidan have been shown to vary depending on its structure, while it can target multiple receptors or signaling molecules in various cell types, including tumor cells and immune cells. Low toxicity and the in vitro effects of fucoidan mentioned above make it a suitable agent for cancer prevention or treatment. However, preclinical development of natural marine products requires in vivo examination of purified compounds in animal tumor models. This review discusses the effects of systemic and local administration of fucoidan on tumor growth, angiogenesis, and immune reaction and whether in vivo and in vitro results are likely applicable to the development of fucoidan as a marine anticancer drug.

read more

01:49

Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. GreenMedInfo

PMID:  CNS Neurosci Ther. 2014 Dec ;20(12):1036-44. Epub 2014 Nov 15. PMID: 25399812 Abstract Title:  Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: Role of NADPH oxidase-1. Abstract:  AIMS: To explore the effect of fucoidan treatment on oxidative stress-mediated dopaminergic neuronal damage and its potential mechanisms.METHODS: The effect of fucoidan was investigated in a 6-hydroxydopamine (6-OHDA) rat model of PD, an animal model considered appropriate for preclinical studies of PD therapy. The effects of fucoidan treatment on animal behavior and the survival ratio of dopaminergic neurons were investigated. We further observed the effect of fucoidan on microglia and the NADPH oxidases-1 (Nox1), a family of enzymes generating reactive oxygen species (ROS).RESULTS: We found that chronic fucoidan administration mitigated the motor dysfunction induced by 6-OHDA. Similarly, fucoidan reduced the loss of DA neurons in the SNc and DA fibers in the striatum in 6-OHDA-lesioned rats. Moreover, we found that fucoidan inhibited the 6-OHDA-stimulating expression of Nox1 in both tyrosine hydroxylase (TH)-positive neurons and non-TH-positive neurons, prevented Nox1-sensitive oxidative stress and cell damage in SNc neurons. Fucoidan also effectively inhibited nigral microglial activation.CONCLUSION: These results support the beneficial effect of fucoidan in 6-OHDA-lesioned rat model of PD. Fucoidan may suppress the Nox1-triggered oxidative stress in the SNc to protect DA neurons from 6-OHDA-induced toxicity and achieve its beneficial effect.

read more

01:41

Sheridan: Fluoride, Handbook, on Councils Agenda Fluoride Action Network

The Sheridan City Council at their regularly scheduled meeting Monday night will be discussing a handbook for the Mayor and Council. Sheridan Mayor Roger Miller says that this is something hes been seeking for quite awhile.

Mayor Miller says that the issue of fluoridation of water at the water treatment plants will be addressed in the form of two separate resolutions, the first of which would put the question on the ballot in November, and the second addresses a proposed public opinion survey on water fluoridation.

The Council will meet at 7 pm Monday night on the third floor of City Hall in Council Chambers. A live broadcast of the meeting will be available on AM-1410 KWYO.

*Original article online at https://www.sheridanmedia.com/news/fluoride-handbook-council-s-agenda99579

01:14

FaceBooks War Against Judeo/Christian America BolenReport

4.7 Million Hindus and Muslims, In The US On H-1B Work Visas, Dominate Social Media Decisions Opinion by Deplorable Consumer Advocate Tim Bolen   A January 17th, 2018 article in the San Jose Mercury News titled H-1B: Foreign citizens make up nearly three-quarters of Silicon Valley tech workforce, report says  spilled the beans on FaceBook, Google Continue reading FaceBooks War Against Judeo/Christian America

The post FaceBooks War Against Judeo/Christian America appeared first on BolenReport.

00:41

Fucoidan ameliorated the development of high fat diet-induced NAFLD. GreenMedInfo

PMID:  Environ Toxicol Pharmacol. 2015 Nov ;40(3):907-14. Epub 2015 Oct 23. PMID: 26498267 Abstract Title:  Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease. Abstract:  Fucoidan, a sulfated polysaccharide derived from brown seaweeds, possesses a wide range of pharmacological properties. In the present study, we investigated the therapeutic effect of fucoidan on non-alcoholic fatty liver disease (NAFLD) in rats. Rats were fed a high-fat diet (HFD) for 12 weeks to induce NAFLD. Oral administrations of fucoidan (100mg/kg, orally), metformin (200mg/kg, orally) or the vehicle were started in the last four weeks. Results showed that administration of fucoidan for 4 weeks attenuated the development of NAFLD as evidenced by the significant decrease in liver index, serum liver enzymes activities, serum total cholesterol and triglycerides, fasting serum glucose, insulin, insulin resistance, and body composition index. Further, fucoidan decreased hepatic malondialdehyde as well as nitric oxide concentrations, and concomitantly increased hepatic reduced glutathione level. In addition, the effect of fucoidan was accompanied with significant decrease in hepatic mRNA expressions of tumor necrosis factor-, interleukins-1 and matrix metalloproteinase-2. Furthermore, histopathological examination confirmed the effect of fucoidan. In conclusion, fucoidan ameliorated the development of HFD-induced NAFLD in rats that may be, at least partly, related to its hypolipidemic, insulin sensitizing, antioxidant and anti-inflammatory mechanisms.

read more

00:15

U.S. Health & Human Services NEVER Performed Vaccine Safety Testing As Required By Law And Congress Natural Blaze

By Catherine J. Frompovich

HHS never performed any vaccine safety testing as required by law and Congress in over 30 to 32 years!

Big Pharma vaccine testing lasts only four or five days.

Thanks to the remarkable legal work being done by Robert F. Kennedy, Jr., Esq. and Del Bigtree, we finally have proof via FOIA documents that HHS has defaulted BIG TIME regarding the safety of vaccines.

HHS never has given Congress the safety testing records the law and Congress required because HHS never performed them in 32 years! The 1986 vaccine law mandated HHS to perform safety studies every two years and render the results to Congress.

That unconscionable default by HHS/CDC/FDA should be the very reason for rescinding the 1986 vaccine law.

Furthermore, informed consent regarding vaccines/vaccinations should be mandatory for those who want vaccines; provide automatic vaccine exemptions for those parents and individuals who do not want vaccines, but request exemptions without fear of prosecution against them or their physicians; and, finally, restructure federal U.S. health agencies in the Washington, DC and all 50 states health departments regarding vaccines.

Its a givenHHS, CDC and FDA combine to create a healthcar...

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Saturday, 14 July

22:49

Weekend reads: Kim Kardashian loses an authorship; legal threats follow misconduct allegations; faked job offer leads to prosecution Retraction Watch

Before we present this weeks Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured the retraction of a Nature paper over the objections of Continue reading Weekend reads: Kim Kardashian loses an authorship; legal threats follow misconduct allegations; faked job offer leads to prosecution

21:43

Why Have Unity When We Can Have Polyphony? Mad In America

When I first found the critical psychiatry movement, I thought it would be like any other social justice movement. I assumed that there were a set of core issues that members of this movement shared similar, if not identical, stances on for example, the abolition of involuntary commitment and forced treatment, informed consent about the adverse effects of psychiatric drugs and electroshock therapy, and increased access to peer support and alternatives to mainstream psychiatry.

Leading up to my involvement in the critical psychiatry movement, I had spent a great deal of time in progressive and leftist causes ranging from criminal justice reform to campaigning for Bernie Sanders. Within each of these movements, activists shared very similar beliefs and views on the topic at hand. At protests, rallies, and organizing meetings, I would hear the same ideas, platforms, and phrases uttered by almost every individual.

So you can imagine my surprise when I discovered that not only does the critical psychiatry movement not revolve around a set of core issues or stances, but that every member of the critical psychiatry movement holds radically different beliefs and views from one another. The critical psychiatry movement is not a structured, top-down campaign but a loose coalition of individuals, each with their own distinctly unique set of opinions and values.

I was, at first, disappointed to learn this. If the critical psychiatry movement was not unified around a set of goals or agenda items namely, my goals and agenda items how could anything be accomplished? How would involuntary commitment and forced treatment ever be stopped? How would the public ever fully understand the adverse effects of psychiatric drugs and electroshock? How could people in distress ever be supported in a way that was actually helpful and non-pathologizing?

What I was really wondering and panicking about was: if the critical psychiatry movement was not unified, how would I ever really fully be safe from involuntary commitment and forced treatment? How would my friends and family ever come to realize and validate how much I had been harmed by the mental health system? Without unity, I felt that there was no hope for either of these to be accomplished.

My disappointment began to lift when I became the moderator at Mad in America. Being MIAs moderator means I spend about an hour each day reading every single comment that is posted on our blogs, personal stories, news articles, podcast episodes, and forum. It means I have the opportunity to listen to each of our commenters unique stories, experiences, and perspectives. As moderator, I began to develop an appreciation for the richness and diversity of the critical psychiatry movement.

I have long thought that the experiences we consider madness big emotions and expressions of vulnerability and pain are the very essence of what it means to be human. Unlike the othe...

20:01

Capitalism Is Ruining Science Mad In America

From Jacobin Magazine: When the competitive dictates of capitalism selling your labor if youre a worker, maximizing profit if youre a boss reign over all else, alternative pursuits are inevitably thwarted, no matter how noble. A noble purpose of the science academy, for example, is to provide the resources and encouragement for people to carry out rigorous experiments that will enhance collective knowledge about the world we live in. But those aspirations suffer as austerity-minded administrations stem the tide of federal funding for universities and research, and institutions react by changing their funding models to stay afloat.

Edwards and Roy observe that hypercompetition caused by the proliferation of performance metrics causes academic scientists to emphasize quantity over quality, incentivizes them to cut corners, and selects for the most career-minded rather than science-minded scholars. In short, the dictates of the capitalist market (competition, accumulation, profit-maximization, and increasing labour-productivity) hurt scientific integrity and the collective pursuit of knowledge.

Article 

20:01

Best Of: The Storming of the Bastille AGE OF AUTISM

July 14 is France's Bastille Day. This day can serve as a reminder around the world of the power of women. Mothers. Wives. Sisters. Daughters. Together, we can change the world. Where we see wrongs against our precious children, we...

15:00

Can You Count on Kava Tea for Health? Articles

In some countries, teas are so highly revered that there are ceremonies for it. In Japan and China, tourists watch or participate in tea ceremonies all year round. In some islands in the Pacific, theres a special tea tradition involving a well-loved drink called kava tea or kava kava. Learn more about what makes kava tea special, as well as the side effects to watch out for when trying this drink.

What Is Kava Tea?

Kava tea comes from kava (Piper methysticum), a plant that's native to islands in the South Pacific. Other nicknames for kava tea include kava kava and 'awa.1 Kava kava is usually served in a coconut shell and swallowed in one or two gulps. When drinking it this way, you should mention thoughts of gratitude, especially toward the person who served the drink.2

Kava tea is often consumed before religious rituals or ceremonies, formal functions, social events or get-togethers.3 Aside from cultural impacts, kava tea is respected for its medicinal effects. The kava plants roots and underground stem are also used medicinally and made into extracts, pills and drinks.4

Health Benefits of Kava Tea

Arguably, kava is most known for helping ease anxiety,5,6 restlessness and stress, and in helping people suffering from insomnia because of its potential to induce sleepiness.7,8 However, additional research has discovered other possible health benefits of drinking kava tea:

Improved brain performance: Authors of a 2004 Human Psychopharmacology study discovered that kava extracts promoted better cognitive abilities and cheerfulness.9

Assist people in curbing addictions: According to a 2001 Pacific Health Dialog article, some of kavas active ingredients may assist people who want to resolve their addiction to substances like alcohol, cigars and cigarettes.10,11

Help i...

Understanding the Opioid Epidemic Articles

By Dr. Mercola

According to the U.S. Centers for Disease Control and Prevention (CDC), 115 Americans, on average, die of an opioid overdose every day.1 The increasing use of opioid painkillers and the rampant rates of addiction to them have become a social issue that transcends all geographic and socioeconomic boundaries.

Drug overdoses now affect people of every age, gender and ethnicity. Understanding the Opioid Epidemic is a one-hour PBS documentary designed to highlight some of the issues surrounding the disturbing rates of use and abuse of prescription opioid medications in the U.S.

These potent painkillers are routinely prescribed for the treatment of bodily pain, most often relating to accidents, car crashes, sports injuries or surgery. If you or someone you love is taking opioids or is already addicted, you may find solace and validation by hearing from recovering addicts and their family members. Also featured are patient advocates, doctors and other experts who deal with this issue on a daily basis.

Painkillers Prescribed for Common Medical Conditions Can Be a Gateway to Opioid Addiction

Far from being an epidemic of nameless, faceless people from faraway lands, the U.S. opioid crisis makes front-page news week after week. The headlines include heartbreaking stories from people like Avi and Julie Israel of North Buffalo, New York, whose son Michaels story is featured prominently in the documentary. Michael was diagnosed with Crohns disease at the age of 12. Problems with drug addiction began when Michael transitioned from his pediatrician to a gastroenterologist when he was 18.

To address Michaels pain, the new doctor prescribed hydrocodone (sold under the brand names Norco and Vicodin), a semisynthetic opioid derived from codeine. That one choice changed Michael forever.

After obtaining a court order to review Michaels pharmacy records after his death, the Israels discovered their son had been prescribed 185 pain pills in little more than a 30-day period just a few months before he died.2 I couldnt believe the doctors did this to him, declared Julie. Its indefensible. It changed him chemically forever.

Sadly, after his addiction to prescription opioids and other medications overtook his life, Michael committed...

Once You Learn This Youll Never Throw Out the Avocado Pit Again Articles

By Dr. Mercola

Avocados (Persea americana) are one of the most popular fruits in the U.S., and two-thirds of consumers have purchased them in the past year. According to Hass Avocado Board 2014 tracking,1 60 percent of those purchasing avocados fall into the lovers/enthusiasts category, meaning they purchase at least 37 avocados each year. This is particularly striking since as late as the 1970s, avocados were more of a luxury item or a delicacy.

Avocados are actually a fruit, rich in monounsaturated fats that are easily burned for energy. Including them in your everyday diet helps to increase healthy fat without increasing protein or carbohydrates. Avocados are also high in potassium, which helps to balance your vitally important potassium to sodium ratio.

In the early 20th century, avocados were still called alligator pears due to their green bumpy skin. In a brilliant PR campaign move, avocados were renamed and rose out of obscurity. They subsequently beat the low-fat craze in the 80s and 90s and found their way into the hearts of Americans. The single greatest game-changer may have been avocados entrance into the Super Bowl.2

The California Avocado Commission PR firm held a Guacamole Bowl in the 1990s, gathering recipes from NFL players and taste testing them on fans and reporters. But it's not just the avocado that is rich in vitamins and antioxidants. You might be surprised to find the pit has numerous health benefits as well.

Have You Eaten an Avocado Pit?

While you may be familiar with some of the benefits of eating avocados, this whole time you may have been throwing out the most nutritious part of the fruit. Here are some of the advantages you may enjoy when you take the time to prepare and eat your avocado pits.3

Antioxidant value: The avocado seed is packed with polyphenols. There are over 500 unique polyphenols, collectively known as phytochemicals.4 Plant-based foods tend to be high in polyphenols and the concentration is affected on how the product is grown, farmed, transported, ripened and prepared.

Many throw out the seed and skin. However, a high proportion of polyphenols remain in the seed....

13:04

Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo. GreenMedInfo

PMID:  Acta Biochim Biophys Sin (Shanghai). 2015 Nov ;47(11):925-31. Epub 2015 Sep 9. PMID: 26358321 Abstract Title:  Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo. Abstract:  Fucoidan is one of the major sulfated polysaccharides isolated from brown seaweeds. In this study, we determined the anti-cancer activity of fucoidan on diffuse large B cell lymphoma (DLBCL) cells both in vitro and in vivo. Fucoidan inhibited the growth of DLBCL cells in a dose- and time-dependent manner, and fucoidan treatment provoked G0/G1 cell cycle arrest, which was accompanied by p21 up-regulation and cyclin D1, Cdk4, and Cdk6 down-regulation. Fucoidan also induced caspase-dependent cell apoptosis in DLBCL cell lines and primary DLBCL cell. In addition, fucoidan treatment caused the loss of mitochondrial membrane potential and the release of cytochrome c and apoptosis-inducing factor from the mitochondria into the cytosol. Fucoidan also potentiated the activities of carfilzomib in killing DLBCL cells. Oral administration of fucoidan effectively inhibited tumor growth in xenograft mouse models. Our findings reveal the novel function of fucoidan as an anti-DLBCL agent, which can be used in the clinical treatment of DLBCL.

read more

12:23

Fucoidan had protective effect against hypoxia-induced cardiomyocytes apoptosis. GreenMedInfo

PMID:  Pharm Biol. 2015 ;53(9):1352-7. Epub 2015 Apr 15. PMID: 25874385 Abstract Title:  Cardioprotective effects of fucoidan against hypoxia-induced apoptosis in H9c2 cardiomyoblast cells. Abstract:  CONTEXT: Cardiomyocyte apoptosis plays a critical role in the progress of heart diseases. Fucoidan, a complex-sulfated polysaccharide, has been reported to possess potential cardioprotective efficacy in vivo.OBJECTIVE: The present study determines whether fucoidan could provide cardioprotection on hypoxia-induced cardiomyocyte apoptosis.MATERIALS AND METHODS: H9c2 cardiomyoblast cells were incubated with various concentrations (15, 30, and 60g/ml) of fucoidan in a humidified incubator at 37C with 95% O2 and 5% CO2. After 6h, hypoxia was processed and the cardioprotective effects of fucoidan were evaluated by applying MTT, ELISA, Hoechst 33258 nucleus staining, and western blot.RESULTS: Following a 6h exposure of H9c2 to hypoxic condition, significant reduction was found in cell survival (0.57-fold) and superoxide dismutase (SOD) activity (0.56-fold), which were associated with the increase of malondialdehyde (MDA) level (2.58-fold), creatine phosphokinase (CK, 3.57-fold), and lactate dehydrogenase (LDH) activities (2.39-fold). Moreover, hypoxia-induced apoptosis was confirmed by Hoechst 33258 nuclear staining, and these changes were accompanied by the increase of Bcl-2 (1.27-fold) and Bax expression (2.6-fold). However, preincubation of the cells with fucoidan prior to hypoxia exposure elevated the cell viability (30g/ml, 1.18-fold; 60g/ml, 1.32-fold) and SOD activity (30g/ml, 1.12-fold; 60g/ml, 1.25-fold), but decreased the MDA level (30g/ml, 0.70-fold; 60g/ml, 0.80-fold), CK (30g/ml, 0.69-fold; 60g/ml, 0.76-fold), and LDH (30g/ml, 0.67-fold; 60g/ml, 0.86-fold) leakages. Hoechst 33258 nuclear staining observations demonstrated the same protective effect of fucoidan on hypoxia-induced myocardial injury. Also, cardioprotective effects of fucoidan were reflected by increasing Bcl-2 (60g/ml, 1.84-fold), as well as decreasing Bax (60g/ml, 0.6-fold).CONCLUSION: Fucoidan had protective effect against hypoxia-induced cardiomyocytes apoptosis, and the mechanism might involve protections of the cell from oxidative injury.

read more

12:08

Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line. GreenMedInfo

PMID:  Mol Med Rep. 2015 Nov ;12(5):6649-55. Epub 2015 Aug 25. PMID: 26324225 Abstract Title:  Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species. Abstract:  Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and a high risk of progression to acute myeloid leukaemia (AML). Fucoidan, a complex sulphated polysaccharide isolated from the cell wall of brown seaweeds, has recently attracted attention for its multiple biological activities and its potential as a novel candidate for cancer therapy. In the present study, the anticancer activity of fucoidan was investigated in the MDS/AML cell line SKM1. Fucoidan inhibited proliferation, induced apoptosis and caused G1-phase arrest of the cell cycle in SKM1 cells as determined by a cell counting kit 8 assay and flow cytometry. Furthermore, reverse transcription quantitative polymerase chain reaction and western blot analyses indicated that treatment with fucoidan (100 g/ml for 48 h) activated Fas and caspase8 in SKM1 cells, which are critical for the extrinsic apoptotic pathway; furthermore, caspase9 was activated via decreases in phosphoinositide-3kinase/Akt signaling as indicated by reduced levels of phosphorylated Akt, suggesting the involvement of the intrinsic apoptotic pathway. In addition, fucoidan treatment of SKM1 cells resulted in the generation of reactive oxygen species (ROS) as determined by staining with dichloro-dihydro-fluorescein diacetate. These results suggested that the mechanisms of the anticancer effects of fucoidan in SKM1 are closely associated with cell cycle arrest and apoptotic cell death, which partly attributed to the activation of apoptotic pathways and accumulation of intracellular ROS. Our results demonstrated that Fucoidan inhibits proliferation and induces the apoptosis of SKM1 cells, which provides substantial therapeutic potential for MDS treatment.

read more

11:51

Fucoidan could inhibit of lung cancer in vivo and in vitro. GreenMedInfo

PMID:  Oncotarget. 2014 Sep 15 ;5(17):7870-85. PMID: 25149540 Abstract Title:  Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGF receptor degradation. Abstract:  Fucoidan, a polysaccharide extracted from brown seaweeds, reduces tumor cell proliferation. In this study, we demonstrate that fucoidan reduces tumor size in LLC1-xenograft male C57BL/6 mice. Moreover, we found that LLC1-bearing mice continuously fed fucoidan showed greater antitumor activity than mice with discontinuous feeding. Fucoidan inhibited the in vitro growth of lung cancer cells. Transforming growth factor (TGF) receptors (TGFRs) play important roles in the regulation of proliferation and progression, and high TGFRI expression in lung cancer specimens is associated with a worse prognosis. Herein, using lung cancer cells, we found that fucoidan effectively reduces TGFRI and TGFRII protein levels in vivo and in vitro. Moreover, fucoidan reduces TGFR downstream signaling events, including those in Smad2/3 and non-Smad pathways: Akt, Erk1/2, and FAK phosphorylation. Furthermore, fucoidan suppresses lung cancer cell mobility upon TGF stimulation. To elucidate how fucoidan decreases TGFR proteins in lung cancer cells, we found that fucoidan enhances the ubiquitination proteasome pathway (UPP)-mediated degradation of TGFRs in A549 and CL1-5 cells. Mechanistically, fucoidan promotes Smurf2 and Smad7 to conjugate TGFRs, resulting in TGF degradation; however, Smurf2-shRNA abolishes fucoidan-enhanced UPP-mediated TGFR degradation. Our study is the first to identify a novel mechanism for the antitumor activity of fucoidan, namely decreasing tumor growth by modulating the TGFR/Smad7/Smurf2-dependent axis, leading to TGFR protein degradation and inhibition of lung cancer cell progression invitro and in vivo. Our current findings indicate that fucoidan is a potential therapeutic agent or dietary supplementation for lung cancer, acting via the Smurf2-dependent ubiquitin degradation of TGF receptors.

read more

11:33

Fucoidan reduces inflammatory response in a rat model of hepatic ischemia-reperfusion injury. GreenMedInfo

PMID:  Can J Physiol Pharmacol. 2015 Nov ;93(11):999-1005. Epub 2015 Jun 1. PMID: 26485583 Abstract Title:  Fucoidan reduces inflammatory response in a rat model of hepatic ischemia-reperfusion injury. Abstract:  Ischemia-reperfusion (I/R) injury after a liver transplant is a major cause of severe complications that lead to graft dysfunction. Fucoidan, a complex of sulfated polysaccharides derived from marine brown algae, demonstrated antiapoptotic as well as potential anti-inflammatory properties in previous studies. Fucoidan has also shown protective effects on I/R-injured kidney and heart. However, whether fucoidan can attenuate hepatic I/R injury has not been examined. To clarify the role of fucoidan in hepatic I/R injury, Sprague-Dawley rats were subjected to sham operation or ischemia followed by reperfusion with treatment of saline or fucoidan (50, 100, or 200 mg(kg body mass)(-1)d(-1)). The fucoidan-treated group showed decreased levels of alanine aminotransferase and aspartate aminotransferase compared with the control group. Myeloperoxidase and malondialdehyde activities and mRNA levels of CD11b in the fucoidan-treated group were significantly decreased. Hepatocellular swelling/necrosis, sinusoidal/vascular congestion, and inflammatory cell infiltration were also attenuated in the fucoidan group. The expression of TNF-, IL-6, IL-1, CXCL-10, VCAM-1, and ICAM-1 were markedly decreased in the samples from the fucoidan-treated group. Fucoidan largely prevented activation of the inflammatory signaling pathway, compared with the control group. In summary, fucoidan can protect the liver from I/R injury through suppressing activation of the inflammatory signaling pathway, as well as the expression of inflammatory mediators, and inflammatory cell infiltration.

read more

11:11

SafeMinds Presents Fashion Rocks Autism 2018! AGE OF AUTISM

Fashion Rocks Autism 2018, New Time, New Location! Join in the fun as Fashion Rocks Autism at The Valley Mansion in Hunt Valley, the seasons most meaningful, memorable, and fun event! When: Friday, September 28, 2018, 7-10 p.m. Cost: $125...

11:10

Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes. GreenMedInfo

PMID:  Int J Mol Med. 2015 Apr ;35(4):1067-73. Epub 2015 Feb 9. PMID: 25672488 Abstract Title:  Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-B signaling pathway in vivo and in vitro. Abstract:  Fucoidan, an extract of the seaweed, Fucus vesiculosus, has been widely investigated for its antioxidant effects. However, to date and to the best of our knowledge, pathological studies on the effects of fucoidan against diabetic nephropathy (DN) related to spontaneous diabetes have not been carried out. DN is one of the most serious microvascular complications of diabetes. Therefore, in the present study, the effects of fucoidan against DN related to spontaneous diabetes were investigated in vitro and in vivo. Goto-Kakizaki (GK) rats were allowed free access to standard rat food with or without fucoidan for 13 weeks, and Wistar rats were used as controls. Fucoidan did not show any cytotoxicity on glomerular mesangial cells (GMCs) which were separated from rat kidneys. Fasting blood glucose levels were measured using a blood glucose meter, blood urea nitrogen (BUN) and serum creatinine (Cr) levels were measured using an automatic biochemistry analyzer and urine protein levels were measured using an ELISA kit. Collagen levels in the renal cortex were measured using an ELISA kit, and the expression levels of transforming growth factor-1 (TGF-1) and fibronectin (FN) in the renal cortex and GMCs, and nuclear factor-B (NF-B) in GMCs were determined by western blot analysis. Fasting blood glucose, BUN, serum Cr, urine protein and collagen levels, and the expression of TGF-1 and FN, as well as NF-B p65 nuclear translocation all significantly increased in the GK rats compared with the control Wistar rats. The increase in the fasting blood glucose, BUN, serum Cr, urine protein and collagen levels in the renal cortex was reversed in the GK rats which were orally administered fucoidan. The oral administration of fucoidan also decreased the expression of TGF-1 and FN in the renal cortex and GMCs, as well as the nuclear translocation of NF-B p65 in the GMCs. Taken together, the data from our in vitro and in vivo experiments indicate that fucoidan attenuates hyperglycemia and prevents or impedes the development of DN related to spontaneous diabetes by attenuating the activation of the NF-B signaling pathway.

read more

10:58

These results suggest that caffeic acid may ameliorate hepatic steatosis. GreenMedInfo

PMID:  Nutrition. 2018 Mar 28 ;55-56:63-70. Epub 2018 Mar 28. PMID: 29960159 Abstract Title:  Caffeic acid ameliorates hepatic steatosis and decreased endoplasmic reticulum stress in high-fat diet-induced obese mice by regulating autophagy. Abstract:  OBJECTIVE: Non-alcoholic fatty liver disease is characterized by high hepatic triacylglycerol contents, which is associated with endoplasmic reticulum (ER) stress and insulin resistance. Caffeic acid (CA) has antioxidant, immunomodulatory, and antiinflammatory effects. We investigated the effects of CA on hepatic steatosis and its mechanism of action.METHODS: We treated CA (50M) with AML12 cells. We categorized mice into three groups as follows: low-fat diet mice (LFD, n=10), high-fat diet-induced obese mice (HFD, n=10), and HFD fed with CA (50mg/kg/d, n=10) for 10wk.RESULTS: CA did not cause any cytotoxic effect on AML12 cell line within the range of concentrations tested (0-200M). We found that CA (50M) treatment in palmitate-treated AML12 hepatocytes reduced lipid accumulation and lipogenesis markers, decreased ER stress, and increased autophagy markers. However, there was no significant difference in lipid droplets of palmitate-treated AML12 hepatocytes and CA-treated autophagy-related protein 7 deficiency AML12 hepatocytes with palmitate. Similarly, CA significantly lowered body and liver weights. Lipid accumulation in the liver decreased in the HFD+CA group compared with the HFD group. Glucose intolerance and insulin sensitivity also were markedly improved in the HFD+CA group. Moreover, the levels of ER stress markers were decreased in the livers of the HFD+CA group.CONCLUSION: Autophagy markers were increased in the livers of the HFD+CA group. These results suggest that caffeic acid may ameliorate hepatic steatosis and decrease ER stress by increasing autophagy.

read more

10:55

Low-molecular-weight fucoidan may have therapeutic potential in the treatment of rheumatoid arthritis. GreenMedInfo

PMID:  Inflammation. 2015 Oct ;38(5):1777-86. PMID: 25787883 Abstract Title:  Low-Molecular-Weight Fucoidan Inhibits the Viability and Invasiveness and Triggers Apoptosis in IL-1-Treated Human Rheumatoid Arthritis Fibroblast Synoviocytes. Abstract:  Fucoidan is a sulfated polysaccharide found mainly in various species of brown algae and brown seaweed. Here, we investigated the effects of low-molecular-weight (LMW) fucoidan (4 kDa) on interleukin-1beta (IL-1)-stimulated rheumatoid arthritis fibroblast-like synoviocyte (RAFLS). 3-[4,5-Dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay and annexin V/propidium iodide assay were used to assess cell viability and apoptosis, respectively. Transwell assay was performed to evaluate cell invasion. Reverse transcription polymerase chain reaction, Western blot, and enzyme-linked immunosorbent assay analysis was done to measure gene expression and secretion. Nuclear factor-kappa B (NF-B) DNA binding activity was determined by electrophoretic mobility shift assay. LMW fucoidan dose-dependently inhibited the viability and induced apoptosis of IL-1-treated RAFLS. Fucoidan attenuated IL-1-induced invasion of RAFLS and decreased the expression and secretion of metalloproteinase (MMP)-1, MMP-3, and MMP-9. Fucoidan suppressed NF-B binding activity, p65 nuclear translocation, and IB- degradation in IL-1-stimulated RAFLS. Additionally, IL-1-induced phosphorylation of p38 but not ERK or JNK was significantly impaired by fucoidan treatment. LMW fucoidan reduces the viability, survival, and invasiveness of IL-1-treated RAFLS, which is associatedwith inhibition of NF-B and p38 activation. LMW fucoidan may have therapeutic potential in the treatment of rheumatoid arthritis.

read more

10:48

This suggests the potential of using fucoidan against the invasion and metastasis of liver cancer. GreenMedInfo

PMID:  Mar Drugs. 2015 Sep 24 ;13(10):6099-116. Epub 2015 Sep 24. PMID: 26404322 Abstract Title:  Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells. Abstract:  Accumulating evidence has revealed that fucoidan exhibits anti-tumor activities by arresting cell cycle and inducing apoptosis in many types of cancer cells including hepatocellular carcinoma (HCC). Exploring its effect on microRNA expression, we found that fucoidan markedly upregulated miR-29b of human HCC cells. The induction of miR-29b was accompanied with suppression of its downstream target DNMT3B in a dose-dependent manner. The reduction of luciferase activity of DNMT3B 3'-UTR reporter by fucoidan was as markedly as that by miR-29b mimic, indicating that fucoidan induced miR-29b to suppress DNMT3B. Accordingly, the mRNA and protein levels of MTSS1 (metastasis suppressor 1), a target silenced by DNMT3B, were increased after fucoidan treatment. Furthermore, fucoidan also down-regulated TGF- receptor and Smad signaling of HCC cells. All these effects leaded to the inhibition of EMT (increased E-cadherin and decreased N-cadherin) and prevention of extracellular matrix degradation (increased TIMP-1 and decreased MMP2, 9), by which the invasion activity of HCC cells was diminished. Ourresults demonstrate the profound effect of fucoidan not only on the regulation of miR-29b-DNMT3B-MTSS1 axis but also on the inhibition of TGF- signaling in HCC cells, suggesting the potential of using fucoidan as integrative therapeutics against invasion and metastasis of HCC.

read more

10:22

Manuka honey is a potent cariostatic agent. GreenMedInfo

PMID:  Int J Clin Pediatr Dent. 2018 Mar-Apr;11(2):105-109. Epub 2018 Apr 1. PMID: 29991862 Abstract Title:  Manuka Honey: A Potent Cariostatic Agent- AnStudy. Abstract:  Aim: The aim of the study was to test the antibacterial activity of manuka honey and compare its efficacy with another commercially available honey (Dabur honey) on the cariogenic bacteria onandMaterials and methods: Anstudy was carried out on 40 agar specimens; the samples were divided into two groups of 20 samples consisting of S.andrespectively. The 20 samples in each group were further subdivided into four groups of five each, which were tested with 25% manuka honey, 100% manuka honey, 25% Dabur honey, and 100% Dabur honey for bothandgroups. The antibacterial activity was tested using the agar well diffusion method againstandAntibacterial activity was assessed by measuring the diameter of inhibition of zones surrounding the wells. The results obtained were statistically analyzed (one-way analysis of variance test, p-value).Results: The results showed that 25% of manuka honey has statistically significant (p 0.001) antibacterial effect than 25% of Dabur honey on bothandspecies, and manuka honey with 100% concentration showed a statistically significant (p 0.001) antibacterial effect than 100% Dabur honey on the same species of bacteria. 100% of both the honeys showed statistically significant (p 0.001) antibacterial effect than 25% concentrations of the same onandConclusion: Manuka honey had more antibacterial activity than Dabur honey onandbacteria in thestudy. This effect was dependent on the concentration of honey used.Beena JP, Sahoo P, Konde S, Raj SN, Kumar NC, Agarwal M. Manuka Honey: A Potent Cariostatic Agent-AnStudy. Int J Clin Pediatr Dent 2018;11(2):105-109.

read more

09:38

Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers. GreenMedInfo

PMID:  Life Sci. 2018 Jun 1. Epub 2018 Jun 1. PMID: 29864436 Abstract Title:  Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers affecting NF-B and NOS2 and NRF2 expression. Abstract:  AIMS: In pressure ulcers, the synthesis of reactive oxygen species induced by ischemia and reperfusion leads to chronic inflammation and tissue damage, which impair the closure of these lesions. Caffeic acid phenethyl ester (CAPE), found in propolis, promotes cutaneous wound healing of acute lesions and severe burns. However, the effects of CAPE on wound healing of pressure ulcers have not been investigated. This study investigated the effects of CAPE administration in a murine model of pressure ulcers.MAIN METHODS: To induce pressure ulcers, two cycles of ischemia and reperfusion by external application of two magnetic plates were performed in the skin dorsum of mice. After the last cycle, animals were treated daily with CAPE or vehicle until they were euthanized.KEY FINDINGS: The nitric oxide synthesis, lipid peroxidation, macrophage migration, protein nuclear factor kappa B and nitric-oxide synthase-2 expression were increased 3days after ulceration but decreased 7days later, in pressure ulcers of the CAPE group compared to that of the control group. CAPE reduced the protein expression of nuclear factor-erythroid2-related factor 2 in pressure ulcers 3days after ulceration, but increased 7days later. Myofibroblast density was increased in the CAPE group 7days after ulceration, but reduced 12days later when compared to control group. In addition, CAPE promoted collagen deposition, re-epithelialization and wound closure of mice pressure ulcers 12days after ulceration.SIGNIFICANCE: CAPE brings forward inflammatory response and oxidative damage involved in injury by ischemia and reperfusion, promoting dermal reconstruction and closure of pressure ulcers.

read more

09:16

One Way To Increase Your Beneficial Bacteria Without Any Food PreventDisease.com

It turns out that exercise can do more than slim down your waistline and boost heart health. It might also make whats inside your gut healthier, according to a new study by San Francisco State University.

08:33

Functional glucose-bound gold nanoparticles enhanced radiation sensitivity and toxicity in prostate cancer cells. GreenMedInfo

PMID:  Clin Invest Med. 2008 ;31(3):E160-7. PMID: 18544279 Abstract Title:  Enhanced radiation sensitivity in prostate cancer by gold-nanoparticles. Abstract:  PURPOSE: Nanotechnology is an emerging field with significant translational potential in medicine. In this study, we applied gold nanoparticles (GNP) to enhance radiation sensitivity and growth inhibition in radiation-resistant human prostate cancer cells.METHODS: Gold nanoparticles (GNPs) were synthesized using HAuCl4 as the gold particle source and NaBH4 as the reductant. Either thio-glucose or sodium citrate was then added to the solution separately to bind the GNPs to form thio-glucose-capped gold nanoparticles (Glu-GNP) and neutral gold nanoparticles (TGS-GNPs). Human prostate carcinoma DU-145 cells were exposed to vehicle, irradiation, 15nM TGS-GNPs, or 15nM Glu-GNPs, or GNPs plus irradiation. The uptake assays of GNP were performed using hemocytometer to count cells and the mass spectrometry was applied to calculate gold mass. The cytotoxicity induced by GNPs, irradiation, or GNPs plus irradiation was measured using a standard colorimetric MTT assay.RESULTS: Exposure to Glu-GNPs resulted in a three times increase of nanoparticle uptake compared to that of TGS-GNPs in each target cell (p

read more

08:24

Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. GreenMedInfo

PMID:  Int J Radiat Oncol Biol Phys. 2011 Feb 1 ;79(2):531-9. Epub 2010 Nov 20. PMID: 21095075 Abstract Title:  Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Abstract:  PURPOSE: Gold nanoparticles (GNPs) have been shown to cause sensitization with kilovoltage (kV) radiation. Differences in the absorption coefficient between gold and soft tissue, as a function of photon energy, predict that maximum enhancement should occur in the kilovoltage (kV) range, with almost no enhancement at megavoltage (MV) energies. Recent studies have shown that GNPs are not biologically inert, causing oxidative stress and even cell death, suggesting a possible biological mechanism for sensitization. The purpose of this study was to assess GNP radiosensitization at clinically relevant MV X-ray energies.METHODS AND MATERIALS: Cellular uptake, intracellular localization, and cytotoxicity of GNPs were assessed in normal L132, prostate cancer DU145, and breast cancer MDA-MB-231 cells. Radiosensitization was measured by clonogenic survival at kV and MV photon energies and MV electron energies. Intracellular DNA double-strand break (DSB) induction and DNA repair were determined and GNP chemosensitization was assessed using the radiomimetic agent bleomycin.RESULTS: GNP uptake occurred in all cell lines and was greatest in MDA-MB-231 cells with nanoparticles accumulating in cytoplasmic lysosomes. In MDA-MB-231 cells, radiation sensitizer enhancement ratios (SERs) of 1.41, 1.29, and 1.16 were achieved using 160 kVp, 6 MV, and 15 MV X-ray energies, respectively. No significant effect was observed in L132 or DU145 cells at kV or MV energies (SER 0.97-1.08). GNP exposure did not increase radiation-induced DSB formation or inhibit DNA repair; however, GNP chemosensitization was observed in MDA-MB-231 cells treated with bleomycin (SER 1.38).CONCLUSIONS: We have demonstrated radiosensitization in MDA-MB-231 cells at MV X-ray energies. The sensitization was cell-specific with comparable effects at kV and MV energies, no increase in DSB formation, and GNP chemopotentiation with bleomycin, suggesting a possible biological mechanism of radiosensitization.

read more

08:08

Arizona Veterans Group Calls Out Local Law Enforcement and Mayor for Covering Up Pedophile Trafficking Medical Kidnap

Lewis Arthur trusting in God

Lewis Arthur is the head of Tuscon-based Veterans on Patrol, and is quick to testify that he is trusting in God to lead him to shut down cartel pedophile corridors near the border.

by Brian Shilhavy
Editor, Health Impact News

Last month (June 2018) Health Impact News reported on the story out of Tuscon, Arizona, where a group called Veterans on Patrol uncovered a child sex camp that was believed to be used by cartels crossing the border from Mexico to traffick children in the U.S.

Local law enforcement refused to acknowledge that the camp was used in child sex trafficking, and just when it looked like they were going to remove the members of the group from continuing their investigations, something dramatically changed, and the veteran group, now joined by hundreds of volunteers coming in from all over the world, was allowed to continue their patrols in the area.

Their patrols have continued the past few weeks, and the group is claiming that they have shut down some of the human trafficking, as well as drug trafficking, as a result of their efforts.

See our original story:

BREAKING: Vet Group Finds Pedophile Child Sex Camp Near Tucson Local Law Enforcement Refuses to Help as Tensions Rise

The leader of the group, Lewis Arthur, who once enjoyed a great local reputation for his work with getting veterans off of the streets, has come under increasing pressure and criticism from local law enforcement and the corporate-sponsored media.

He recently vented some of his frustration on a Facebook Live-stream broadcast, where he accused local law enforcement and the Tucson mayor, Jonathan Rothschild, for covering up known pedophile groups operating within Tucson, Arizona.

Throughout his broadcast, Arthur makes is clear that he is being driven by a mission he believes has been given to them from God, and his trust that God will protect him from those seeking to destroy him and his credibility.

He believes that their work is revealing the truth about human trafficking coming across the border, and its link to pe...

07:55

Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. GreenMedInfo

PMID:  Nanomedicine (Lond). 2013 Oct ;8(10):1601-9. Epub 2012 Dec 24. PMID: 23265347 Abstract Title:  Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Abstract:  AIM: To test intravenously injected gold nanoparticles for x-ray imaging and radiotherapy enhancement of large, imminently lethal, intracerebral malignant gliomas.MATERIALS & METHODS: Gold nanoparticles approximately 11 nm in size were injected intravenously and brains imaged using microcomputed tomography. A total of 15 h after an intravenous dose of 4 g Au/kg was administered, brains were irradiated with 30 Gy 100 kVp x-rays.RESULTS: Gold uptake gave a 19:1 tumor to normal brain ratio with 1.5% w/w gold in tumor, calculated to increase local radiation dose by approximately 300%. Mice receiving gold and radiation (30 Gy) demonstrated 50% long term (>1 year) tumor-free survival, whereas all mice receiving radiation only died.CONCLUSION: Intravenously injected gold nanoparticles cross the blood-tumor barrier, but are largely blocked by the normal blood-brain barrier, enabling high-resolution computed tomography tumor imaging. Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. This approach holds promise to improve therapy of human brain tumors and other cancers.

read more

07:54

Arizona Veterans Group Calls Out Local Law Enforcement and Mayor for Covering Up Pedophile Trafficking Health Impact News

Lewis Arthur trusting in God

Lewis Arthur is the head of Tuscon-based Veterans on Patrol, and is quick to testify that he is trusting in God to lead him to shut down cartel pedophile corridors near the border.

by Brian Shilhavy
Editor, Health Impact News

Last month (June 2018) Health Impact News reported on the story out of Tuscon, Arizona, where a group called Veterans on Patrol uncovered a child sex camp that was believed to be used by cartels crossing the border from Mexico to traffick children in the U.S.

Local law enforcement refused to acknowledge that the camp was used in child sex trafficking, and just when it looked like they were going to remove the members of the group from continuing their investigations, something dramatically changed, and the veteran group, now joined by hundreds of volunteers coming in from all over the world, was allowed to continue their patrols in the area.

Their patrols have continued the past few weeks, and the group is claiming that they have shut down some of the human trafficking, as well as drug trafficking, as a result of their efforts.

See our original story:

BREAKING: Vet Group Finds Pedophile Child Sex Camp Near Tucson Local Law Enforcement Refuses to Help as Tensions Rise

The leader of the group, Lewis Arthur, who once enjoyed a great local reputation for his work with getting veterans off of the streets, has come under increasing pressure and criticism from local law enforcement and the corporate-sponsored media.

He recently vented some of his frustration on a Facebook Live-stream broadcast, where he accused local law enforcement and the Tucson mayor, Jonathan Rothschild, for covering up known pedophile groups operating within Tucson, Arizona.

Throughout his broadcast, Arthur makes is clear that he is being driven by a mission he believes has been given to them from God, and his trust that God will protect him from those seeking to destroy him and his credibility.

He believes that their work is revealing the truth about human trafficking coming across the border, and its link to...

07:49

Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres. GreenMedInfo

PMID:  J Appl Toxicol. 2010 Apr ;30(3):212-7. PMID: 19902477 Abstract Title:  Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres. Abstract:  Using a series of gold nanoparticles with incremental increase in dimensions but varying geometries (spherical vs rods) we have evaluated the influence of shape, size, surface properties and concentration on cellular uptake, adsorption of proteins and toxicity in a human prostate cancer cell line (PC-3). In the range of 30-90 nm diameter studied, spherical particles of 50 nm in diameter without polyethylene glycol (PEG) had the highest uptake. Surface attachment of PEG reduced cellular uptake. PEGylated gold nanorods had a net positive charge compared with their spherical counterparts and particle geometry influenced cellular uptake. In the absence of serum proteins the uptake of plain spherical GNPs increased. These studies pave the way for the tailoring of gold nanoparticles for targeted tumor therapy applications.

read more

07:16

Preclinical evaluation of gold nanoparticles as theranostic agents in prostate cancer radiotherapy. GreenMedInfo

PMID:  Nanomedicine (Lond). 2016 08 ;11(16):2035-47. Epub 2016 Jul 27. PMID: 27463088 Abstract Title:  Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy. Abstract:  AIM: Gold nanoparticles have attracted significant interest in cancer diagnosis and treatment. Herein, we evaluated the theranostic potential of dithiolated diethylenetriamine pentaacetic acid (DTDTPA) conjugated AuNPs (Au@DTDTPA) for CT-contrast enhancement and radiosensitization in prostate cancer.MATERIALS & METHODS: In vitro assays determined Au@DTDTPA uptake, cytotoxicity, radiosensitizing potential and DNA damage profiles. Human PC3 xenograft tumor models were used to determine CT enhancement and radiation modulating effects in vivo.RESULTS: Cells exposed to nanoparticles and radiation observed significant additional reduction in survival compared with radiation only. Au@DTDTPA produced a CT enhancement of 10% and a significant extension in tumor growth delay from 16.9 days to 38.3 compared with radiation only.CONCLUSION: This study demonstrates the potential of Au@DTDTPA to enhance CT-image contrast and simultaneously increases the radiosensitivity of prostate tumors.

read more

06:51

This review summarizes the role of gold nanoparticles in immunotherapy agent delivery. GreenMedInfo

PMID:  Nanomedicine. 2014 Apr ;10(3):503-14. Epub 2013 Oct 5. PMID: 24103304 Abstract Title:  Gold nanoparticle mediated cancer immunotherapy. Abstract:  UNLABELLED: Significant progress has been made in the field of cancer immunotherapy, where the goal is to activate or modulate the body's immune response against cancer. However, current immunotherapy approaches exhibit limitations of safety and efficacy due to systemic delivery. In this context, the use of nanotechnology for the delivery of cancer vaccines and immune adjuvants presents a number of advantages such as targeted delivery to immune cells, enhanced therapeutic effect, and reduced adverse outcomes. Recently, gold nanoparticles (AuNP) have been explored as immunotherapy carriers, creating new AuNP applications that merit a critical overview. This review highlights recent advances in the development of AuNP mediated immunotherapies that harness AuNP biodistribution, optical properties and their ability to deliver macromolecules such as peptides and oligonucleotides. It has been demonstrated that the use of AuNP carriers can improve the delivery and safety of immunotherapy agents, and that AuNP immunotherapies are well suited for synergistic combination therapy with existing cancer therapies like photothermal ablation.FROM THE CLINICAL EDITOR: Cancer immunotherapy approaches are rapidly evolving and are some of the most promising avenues to approach malignancies. This review summarizes the role of gold nanoparticles in immunotherapy agent delivery, and in the development of synergistic therapies such as photothermal ablation.

read more

06:10

Survival Medicine Hour: Antibiotics, Bears Pt.2, Nutrition with Amy Doom and Bloom (TM)

Survival Medicine Hour: Antibiotics, Bears Pt.2, Nutrition with Amy

SURVIVAL MEDICINE HOUR PODCAST The human body is a marvel of biologic engineering. Its immune system usually kills bacteria and other harmful germs before they can multiply and cause symptoms. Our blood contains white cells, also known as leukocytes that attack bacteria. Even if we do experience symptoms, our bodies can usually cope and fight []

05:56

Facebook Purges Over 80 Accounts in Sweeping Attack on the Alternative Media Natural Blaze

Facebook Purges Over 80 Accounts in Sweeping Attack on the Alternative Media

 

By Phillip Schneider

Starting in June of 2018, Facebook began deleting pages with up to 40 million followers in an unprecedented assault on independent media outlets using the platform. 

Jake Passi, the founder of the popular Facebook page Collectively Conscious and victim of the purge called the effort a deleting rampage and a crime against humanity. 

A website known as Swapd which allows for the buying and selling of Facebook pages issued a statement confirming that the pages were in fact being taken down by Facebook. 

After days of new reports coming in, were 100% sure Facebook is cleaning the house, hard. They are taking no hostages and deleting millions of fans without any hesitation. It doesnt matter if your page is 50k or 40m, theyre all at risk. Swapd.co 

Several commenters claimed to have had their pages taken down as well, including one user who claimed to run 10 pages about dogs, machines, trucks, [and] farming. 

...

05:35

Effects of internalized gold nanoparticles with respect to cytotoxicity and invasion activity in lung cancer cells. GreenMedInfo

PMID:  PLoS One. 2014 ;9(6):e99175. Epub 2014 Jun 5. PMID: 24901215 Abstract Title:  Effects of internalized gold nanoparticles with respect to cytotoxicity and invasion activity in lung cancer cells. Abstract:  The effect of gold nanoparticles on lung cancer cells is not yet clear. In this study, we investigated the cytotoxicity and cell invasion activity of lung cancer cells after treatment with gold nanoparticles and showed that small gold nanoparticles can be endocytosed by lung cancer cells and that they facilitate cell invasion. The growth of A549 cells was inhibited after treatment with 5-nm gold nanoparticles, but cell invasion increased. Endocytosed gold nanoparticles (size, 10 nm) notably promoted the invasion activity of 95D cells. All these effects of gold nanoparticles were not seen after treatment with larger particles (20 and 40 nm). The enhanced invasion activity may be associated with the increased expression of matrix metalloproteinase 9 and intercellular adhesion molecule-1. In this study, we obtained evidence for the effect of gold nanoparticles on lung cancer cell invasion activity in vitro. Moreover, matrix metalloproteinase 9 and intercellular adhesion molecule-1, key modulators of cell invasion, were found to be regulated by gold nanoparticles. These data also demonstrate that the responses of the A549 and 95D cells to gold nanoparticles have a remarkable relationship with their unique size-dependent physiochemical properties. Therefore, this study provides a new perspective for cell biology research in nanomedicine.

read more

04:28

Congressional Committee Investigation Exposes History of Testing on American Soldiers Natural Blaze

Congressional Committee Investigation Exposes History of Testing on American Soldiers

By Brandon TurbevilleNatural Blaze

In 1995, a PH.D candidate in Maritime Studies (specifically Chemical Pollution), by the name of H. Lindsey Arison III, wrote a report entitled The Cover-Up of Gulf War Syndrome A Question of National Integrity, where he discussed the toxic chemicals that American service personnel were exposed to during the first American invasion of Iraq and how that exposure may have been the cause or one important contributing factor to the mysterious Gulf War Syndrome that plagued so many soldiers and their families upon returning home.

Dr. Arison concluded:

The Department of Defense, the Central Intelligence Agency, and the Department of Veterans Affairs have been lying to the U.S. Congress, Gulf War veterans, and the American people about coalition forces exposure to chemical and biological agents during the war.

This criminal, reprehensible, shameful, dishonorable, and egregious act on their part has caused incalculable pain and suffering, caused many who risked their lives for...

04:11

The Evidence is In! Raw Milk Actually Boost Immunity & Prevents Infections Healthy Holistic Living

Theres something about the health industry today that wants us to believe that foods need to be covered in pesticides, genetically modified, or thoroughly pasteurized before the human body can consume it. In the case of milk, the United States Food and Drug Administration (FDA) would prefer us to have the opinion that raw milk... View Article

The post The Evidence is In! Raw Milk Actually Boost Immunity & Prevents Infections appeared first on Healthy Holistic Living.

03:52

Farmers Reveals the Secret to Keeping Berries Fresh for Weeks Healthy Holistic Living

Its summertime. That means fruit salads, fresh berries, and strawberry shortcake galore. You can find strawberries in plenty in your local grocery and farmers market, but no matter how fresh you get them, berries always seem to go bad after a few days at home. It doesnt seem to matter how quickly you eat them,... View Article

The post Farmers Reveals the Secret to Keeping Berries Fresh for Weeks appeared first on Healthy Holistic Living.

03:43

A Glowing Red Blood Moon In July Will Be The Longest Lunar Eclipse In A Century Healthy Holistic Living

Lunar eclipses have fascinated people all over the world since the very beginning of time, and with good reason. There is some truly amazing stuff out there, and it never ceases to amaze! This months sky holds some pretty exciting events that you definitely wont want to miss. What Is A Lunar Eclipse? A lunar... View Article

The post A Glowing Red Blood Moon In July Will Be The Longest Lunar Eclipse In A Century appeared first on Healthy Holistic Living.

03:36

The Spiritual Consequences Of Alcohol Consumption Healthy Holistic Living

Alcoholic beverages are widely produced, sold, and consumed by people all around the world. For some people alcohol consumption is an integral part of their lifestyle. There is substantial research showing the negative physical effects of alcohol on the body, such as a change in mood or behavior, liver inflammations, and even the development of... View Article

The post The Spiritual Consequences Of Alcohol Consumption appeared first on Healthy Holistic Living.

03:09

$4.69 billion verdict against Johnson & Johnsons talcum powder Health Nut News

On Thursday, after just 8 hours of deliberations, a St. Louis jury awarded $4.69 billion to 22 women who alleged that their ovarian cancer was caused by using Johnson & Johnson powder as a part of their daily feminine hygiene routine. This comes after J&J paid $80 million in punitive damages (in addition to the $37 []

The post $4.69 billion verdict against Johnson & Johnsons talcum powder appeared first on Health Nut News.

02:35

A review of gold nanoparticles in cancer therapy. GreenMedInfo

PMID:  Curr Pharm Des. 2015 ;21(29):4240-51. PMID: 26323426 Abstract Title:  Gold Nanoparticles in Cancer Therapy: Efficacy, Biodistribution, and Toxicity. Abstract:  Gold-based nanoparticles are utilized for cancer therapeutics as a system for drug delivery, or as a mediator for thermal therapy, whether ablation or hyperthermia. This review discusses how the design of the physicochemical properties of the different types of gold-based nanoparticles affects their treatment efficacy. The basic principles and mechanism at which it mediates heating and delivers drugs efficiently in vivo is also summarized. We will also review the in vivo preclinical data on the biodistribution, intratumoral distribution, cell internalization, and its associated toxicity. Lastly, an updated list of the clinical trials based on nanoparticles and future perspectives are provided.

read more

02:26

Loading chemotherapeutic drugs into multifunctional gold nanospheres can increase antitumor potency. GreenMedInfo

PMID:  J Drug Target. 2015 ;23(6):568-76. Epub 2015 Mar 4. PMID: 25738990 Abstract Title:  Effective photothermal chemotherapy with docetaxel-loaded gold nanospheres in advanced prostate cancer. Abstract:  BACKGROUND: Multifunctional gold nanospheres (MGNs)-loaded with docetaxel (MGN@DTX) were prepared and evaluated for therapeutic efficacy in nude mice bearing human prostate cancer xenografts.METHODS: MGNs were prepared from PEGylated hollow gold nanospheres (HGNs) coated with folic acid and DTPTT chelate. Then, the effect of radiolabelled MGNs ((99m)Tc-MGNs) on PC-3 cell apoptosis was assessed by flow cytometry, while their binding affinity to these cells was evaluated by cell binding assays. Next, biodistribution of (99m)Tc-MGNs in xenograft bearing mice was measured by SPECT imaging. Also, DTX loading and release rates were estimated in MGN@DTX. Finally, in vitro stability in human serum and cytotoxicity of MGN@DTX were assessed, as well as their antitumor effect in xenograft bearing mice.RESULTS: (99m)Tc-MGNs (97.69% purity) showed good binding affinity to PC-3 cells, a specific recognition blocked by excess folic acid. Interestingly, MGN@DTX remained stable in human serum for 24 h, and exhibited higher mean cytotoxicity after NIR laser irradiation than free DTX. By day 28, tumor inhibition rates were higher in the MGN@DTX+NIR laser irradiation group compared with the DTX and MGNs+NIR laser irradiation groups.CONCLUSIONS: Loading chemotherapeutic drugs into MGNs can increase antitumor potency, reduce normal cell damage and decrease drug resistance, thus representing a promising approach for advanced prostate cancer treatment.

read more

01:39

Secret Documents Expose Monsantos War on Cancer Scientists Natural Blaze

Secret Documents Expose Monsantos War on Cancer Scientists

By Stacy Malkan

DeWayne Johnson, a 46-year-old father dying of non-Hodgkin lymphoma, became the first person to face Monsanto in trial this week over allegations the company hid evidence about the cancer-causing dangers of its Roundup weedkiller. Johnson is the first of some 4,000 people suing Monsanto in state and federal courts claiming their cancers were caused by glyphosate-based Roundup. The litigation, and documents coming to light because of it, are shining light on the heavy-handed tactics Monsanto (now a subsidiary of Bayer) has used to deny cancer risk and protect the chemical that is the lynchpin of its profits.

 

Monsanto was its own ghostwriter for some safety reviews, Bloomberg reported, and an EPA official reportedly helped Monsanto kill another agencys cancer study. An investigation in Le Monde details Monsantos effort to destroy the United Nations cancer agency by any means possible to save glyphosate.

Two recent journal articles, based on reviews of the Roundup trial discovery documents, report...

01:34

Study Will Measure Quality Of Northern Wisconsin Groundwater Fluoride Action Network

First-Ever Private Well Testing Will Measure Fluoride, Metal Levels In 11 Counties

A first-of-its-kind groundwater quality study in 11 northern Wisconsin counties will focus on whats in the drinking water of private wells.

The University of Wisconsin-Superiors Lake Superior Research Institute has received a nearly $56,000 grant from the Wisconsin Department of Natural Resources to conduct the voluntary 18-month study.

We have in northwestern Wisconsin a really large proportion of people that are on (private) well water. I think were pretty unique in that way, said Kelsey Prihoda, a researcher with the Lake Superior Research Institute who is leading the study. Private wells, theres no requirement that they be monitored, as opposed to a public wells.

The goal is to collect 700 water samples from private wells in the 11 counties. The level of fluoride will be measured in each sample. Prihoda said they want to find out if most of the water contains .7-1.5 miligrams per liter of fluoride which is thought to be a healthy level to consume for good teeth and bone development.

If its less than that, then it actually is conducive to having some sort of a dental cavity, tooth decay sort of thing. So, we would want in that situation to supplement with some sort of a fluoride varnish or fluoride treatment, she said. If its above that, thats where you start to see issues on the other end of the spectrum where there are some malformations in the enamel on teeth.

The study will also look at metal levels in about 10 samples per county like arsenic, iron, magnesium and aluminum to form a baseline of data that can be used in future groundwater studies in northern Wisconsin.

If in the future, there are big industries that come in, or some sort of contaminant level occurrence that would affect our groundwater, we would be able to know what changes had occurred based on human impacts on groundwater, she said.

While this may be the first time the groundwater quality of private wells has been studied in northern Wisconsin, groundwater quality has become...

01:31

3 Medicinal Herbs You Can Grow Indoors Natural Blaze

3 Medicinal Herbs You Can Grow Indoors

By Sara Tipton

The advances in modern medicine are obviously wonderful and have added years to the average Americans lifespan.  But what will you do when medical care isnt so readily available, such as in a survival scenario or for a mild ailment?  Hopefully, this list of three medicinal herbs that everyone can easily grow in their own home will help you decide if herbal medicine could be of some aid.

Herbal medicine has been around for much longer than Western medicine, and with interventions like chemotherapy being only 2% effective at the 5-year mark, many are already looking to use mother nature instead of or in addition to radiation treatments to help cure ailments.  That isnt to say you should not undergo chemotherapy, it means only that many are looking out for their health by using nature and diet to affect the appropriate changes in their bodies.

The use of traditional remedies increases when conventional medicine is ineffective in the treatment of disease, such as in advanced cancer and in the face of new infectious diseases. Furthermore, traditional medicines are widely perceived as natural and safe and non-toxic.  Althoug...

01:23

Breastfeeding has been the best public health policy throughout history Natural Blaze

Breastfeeding has been the best public health policy throughout history

By Joan Y. Meek, Florida State University

Breastfeeding has long been the gold standard for infant nutrition. The American Academy of Pediatrics, American Academy of Family Physicians, American College of Obstetricians and Gynecologists, and World Health Organization all recommend it.

Thus, the recent New York Times report of U.S. interference in the World Health Assemblys attempt to adopt the resolution that mothers milk is healthiest for children and countries should strive to limit the inaccurate or misleading marketing of breast milk substitutes alarmed many concerned about public health.

As a pediatrician and a nutritionist, I have provided direct patient care to breastfeeding mothers and children and also advocated for breastfeeding policies and practices. The scientific research in support of breastfeeding is overwhelmingly clear, and most mothers in the U.S. have heard that message and learned from it. Marketing and sales of infant formula have surged in developing countries, however. Thats created a dilemma for the U.S., which has not wanted to restrict the US$70 billion infant formula business.

This comes at another price. Lack of breastfeeding worldwide is blamed for 800,000 childhoo...

01:17

Phytate prevents tissue calcifications in female rats. GreenMedInfo

PMID:  Biofactors. 2000 ;11(3):171-7. PMID: 10875304 Abstract Title:  Phytate prevents tissue calcifications in female rats. Abstract:  The AIN-76 A, a purified rodent diet, has a propensity to cause kidney calcifications in female rats which is not observed with non-purified rodent diets, suggesting a nutritional factor that avoids these calcifications. One candidate is phytate, which inhibits crystallisation of calcium salts and is practically absent in purified diets. Therefore, the effects on calcification of kidney tissue of phytate addition to the AIN-76 A diet using female Wistar rats were studied. The rats were assigned to three groups: AIN-76 A, AIN-76 A + 1% phytate and standard nonpurified chow. Urinary phytate of the AIN-76 A fed group was undetectable. Urinary phytate of AIN-76 A + 1% phytate and standard fed groups did not differ and was significantly higher than in the AIN-76 A group. The concentrations of calcium and phosphorus in kidneys were greater in the AIN-76 A group than in AIN-76 A + 1% phytate and standard groups. Only rats of the AIN-76 A group displayed mineral deposits at the corticomedullary junction. These findings demonstrated that the absence of phytate in the AIN-76 A diet is one of the causes of renal calcification in female rats.

read more

01:12

J&J Forced to Pay $4.7 BILLION As Jury Finds They Knowingly Gave Women Cancer with Baby Powder Natural Blaze

By Matt Agorist

Missouri For the last several years, Johnson & Johnson has been battling multiple lawsuits many of which they have lost due to thousands of claims of their baby powder product giving women cancer. On Thursday, a Missouri jury handed down the largest verdict yet, ordering the pharma giant to pay $4.7 billion to victims.

In this latest case, 22 women alleged the companys talc-based products, including its baby powder, contained the known carcinogen, asbestos, which caused them to develop cancer. According to reports, there are over 9,000 similar talc lawsuits against the company.

Naturally, J&J denies that their product causes cancer and that it contains asbestos. However, a government-funded study from the mid-1990s found that Johnsons baby powder caused cancer in rats and other studies have found an increased risk of cancer in women who used talc-based products. The potential risks have been known to the company for decades.

Whats more is the fact that talc in its natural form can contain varying amounts of asbestos and other minerals. If it is not properly filtered, the asbestos can make it through to consumer products.

Th...

00:53

Californias CRAZY Vaccination Policy: No Medical Exemptions Natural Blaze

By Catherine J. Frompovich

The State of California and its health agencies better hand in their credentials because they apparently dont know the facts about Adverse Effects of Drugs or Medicaments!

Equally alarming, health agencies apparently arent aware the CMS (Centers for Medicare and Medicaid Services) released the 2018 ICD-10-CM files in June of 2017 [1] and anyone can find them here.

However, the irony of the above CMS coding system for reimbursement of patients medical treatment services includes several Diagnosis Codes for:

  • Unspecified adverse effect of drug or medicament
  • Adverse effect of unspecified systemic antibiotic, initial encounter
  • Adverse effect of other viral vaccines, initial encounter [CJF emphasis]

Did you get the last one: viral vaccines? What doesnt California get?

Since...

00:45

Adequate consumption of phytate can prevent abdominal aortic calcification in patients with chronic kidney disease. GreenMedInfo

PMID:  J Ren Nutr. 2016 07 ;26(4):226-36. Epub 2016 Mar 12. PMID: 26975775 Abstract Title:  Protective Effect of Myo-Inositol Hexaphosphate (Phytate) on Abdominal Aortic Calcification in Patients With Chronic Kidney Disease. Abstract:  OBJECTIVE: The aim of this study was to evaluate the relationship between physiological levels of myo-inositol hexaphosphate (phytate) and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD).DESIGN AND METHODS: This was a prospective cross-sectional study conducted from December 2012 to June 2013.SUBJECTS: Sixty-nine consecutive patients with CKD who were not undergoing renal replacement therapy.INTERVENTION: All subjects were given lateral lumbar X-rays to quantify abdominal aortic calcification (AAC). Clinical laboratory analyses and phytate food frequency questionnaires were also performed.MAIN OUTCOME MEASURE: Phytate urinary excretion, estimated phytate consumption (based on food frequency questionnaire) and AAC score. Patients were divided into two groups based on median abdominal aortic calcification (AAC) score: no/mild AAC (AAC  6, n = 35) and moderate/severe AAC (AAC > 6, n = 34).RESULTS: Patients with no/mild AAC were younger, had lower pulse pressure, greater dietary intake of phytate, greater urinary phytate and the prevalence of prior CV disease was significantly lower compared to patients with moderate/severe AAC. Among the top 10 phytate-rich foods, lentil consumption was significantly greater in patients with no/mild AAC than in those with moderate/severe AAC. Multivariate logistic regression analysis indicated that age, prior CV disease, urinary phytate (or lentil consumption) were independently associated to AAC.CONCLUSION: Our results suggest that adequate consumption of phytate can prevent AAC in patients with CKD. Further prospective studies must be performed to elucidate the benefits of a phytate-rich diet and the associated risk of phosphorus bioavailability in these patients.

read more

00:43

Proposed Guidance Regarding Operational Control Range Around Optimal Fluoride Concentration in Community Water Systems That Adjust Fluoride Fluoride Action Network

AGENCY:

Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS).

ACTION:

Notice; request for comment.

SUMMARY:

The Centers for Disease Control and Prevention (CDC) in the Department of Health and Human Services (HHS) announces in this Federal Register Notice a proposed operational control range around optimal fluoride concentration in community water systems that adjust fluoride, and monthly adherence to that range. The proposal is based on analysis of available data, provided in the Background document. CDC is opening a docket to obtain comment on the existence of evidence-based concerns about the appropriateness of the proposed operational control range and criteria for adherence based on measurement capacity or feasibility of maintaining a target level. The operational control range specifies upper and lower limits of variation around a target concentration of fluoride. Managers of adjusted water systems at state and local levels need this updated operational control range to ensure the maintenance of consistent monthly averages in fluoride concentration that maximize prevention of tooth decay and minimize the possibility of dental fluorosis. The proposed operational control range is 0.6 mg/L to 1.0 mg/L. CDC bases this guidance on the following considerations: (1) Concentration of fluoride in water shown to prevent tooth decay and (2) Ability of water systems to control variation in fluoride concentration.

DATES:

Written comments must be received on or before October 11, 2018.

ADDRESSES:

You may submit comments, identified by Docket No. CDC-2018-0064 by any of the following methods:

  • Federal eRulemaking Portal: http://www.regulations.gov. Follow the instructions for submitting comments.
  • Mail: Division of Oral Health, Centers for Disease Control and Prevention, 4770 Buford Highway, MS S107-8, Atlanta, Georgia 30341. Attn: Docket Number: CDC-2018-0064.

Instructions: All submissions received must include the agency name and Docket Number. All relevant comments received will be posted without change to http://regulations.gov, including any personal information provided. For access to the docket to read background documents or comments received, go to...

00:29

Just try not to laugh when doing this exercise Health Nut News

Fitness trends come and go, and time will tell if the latest craze is here to stay: goat yoga. Thats right, yoga sessions with goats. The CBS News video above features some of the instructors and enthusiasts of this unusual pairing. At Laughing Frog Yoga studio in Santa Monica, California, pygmy goats Floyd and Rosco []

The post Just try not to laugh when doing this exercise appeared first on Health Nut News.

00:28

Phytate decreases formation of advanced glycation end-products in patients with type 2 diabetes. GreenMedInfo

PMID:  Sci Rep. 2018 Jun 25 ;8(1):9619. Epub 2018 Jun 25. PMID: 29941991 Abstract Title:  Phytate Decreases Formation of Advanced Glycation End-Products in Patients with Type II Diabetes: Randomized Crossover Trial. Abstract:  Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts and it has the ability to chelate metal cations. The binding of IP6 to transition metals suggests that it could be used for the treatment of metal-catalyzed protein glycation, which appears to trigger diabetes-related diseases. Our in vitro studies showed that IP6 reduced the formation of Fe-catalyzed advanced glycation end-products (AGEs). This led us to perform a randomized cross-over trial to investigate the impact of the daily consumption IP6 on protein glycation in patients with type 2 diabetes mellitus (T2DM; n=33). Thus, we measured AGEs, glycated hemoglobin (HbA1c), several vascular risk factors, and urinary IP6 at baseline and at the end of the intervention period. Patients who consumed IP6 supplements for 3 months had lower levels of circulating AGEs and HbA1c than those who did not consume IP6.This is the first report to show that consumption of IP6 inhibits protein glycation in patients with T2DM. Considering that AGEs contribute to microvascular and macrovascular complications in T2DM, our data indicates that dietary supplementation with IP6 should be considered as a therapy to preventthe formation of AGEs and therefore, the development of diabetes-related diseases in patients with T2DM.

read more

00:13

Did fracking cause the Hawaii volcano eruption? Health Nut News

Jon Rappoport, Guest, Waking Times On the Big Island of Hawaii, where the Kilauea volcano has explosively erupted, there is a geothermal energy plant. It is the Puna Geothermal Venture (PGV) Plant, in Puna. There is a long-running debate about whether PGV is fracking. The debate may be a matter of terminology, because in the geothermal process, []

The post Did fracking cause the Hawaii volcano eruption? appeared first on Health Nut News.

00:12

Aspartame: By far the most dangerous substance added to most foods today Health Nut News

Aspartame is the technical name for the brand names NutraSweet, Equal, Spoonful, and Equal-Measure. It was discovered by accident in 1965 when James Schlatter, a chemist of G.D. Searle Company, was testing an anti-ulcer drug. Aspartame was approved for dry goods in 1981 and for carbonated beverages in 1983. It was originally approved for dry []

The post Aspartame: By far the most dangerous substance added to most foods today appeared first on Health Nut News.

00:05

Overcoming adrenal fatigue naturally Health Nut News

In the last decade, the pace of life (and all that comes with it, i.e., stress) has increased. If youve not yet dealt with adrenal fatigue its likely that you will at some point in your life. In fact, Many proponents of this condition estimate that almost every person can experience adrenal fatigue, also known as []

The post Overcoming adrenal fatigue naturally appeared first on Health Nut News.

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Friday, 13 July

23:14

Video: A Short History Of Microbes Doom and Bloom (TM)

Video: A Short History Of Microbes

VIDEO: A SHORT HISTORY OF GERMS In this video, Joe Alton MD discusses a short history of something thats been on our planet for billions of years: microbes! Of course, most microbes are perfectly harmless, but some can kill you. A few can cause worldwide pandemics, like Yersinia Pestis, the bacteria that caused the Black []

22:00

Nearly two years after a university asked for retractions, two journals have done nothing Retraction Watch

How long should a retraction take? Thats a complex question, of course, depending on how long the alleged issues with a paper take to be investigated, whether authors and their lawyers fight tooth-and-nail against a retraction, and other factors. But once a university officially requests a retraction, how long should one take? The Continue reading Nearly two years after a university asked for retractions, two journals have done nothing

12:00

The prevalence of individuals with diabetes was significantly lower among the walnut consumers. GreenMedInfo

n/a PMID:  Diabetes Metab Res Rev. 2018 Jun 21:e3031. Epub 2018 Jun 21. PMID: 29927053 Abstract Title:  Association between walnut consumption and diabetes risk in NHANES. Abstract:  BACKGROUND: Dietary interventions and cohort studies relating tree nut consumption to blood glucose levels suggest a possible effect of walnuts. OBJECTIVE: To examine the associations between walnut consumption and diabetes risk using data from the National Health and Nutrition Examination Survey. METHODS: National Health and Nutrition Examination Survey data on adults conducting 24-hour dietary recall was pooled across the years 1999 through 2014. Diabetes status or risk was based on self-report, medication use, fasting plasma glucose levels, and haemoglobin A1c (HbA) levels. Individuals were characterized based on reported consumption of walnuts, mixed-nuts, or no nuts. RESULTS: After adjustment for covariates, walnut consumers showed lower risk for diabetes compared with non-nut consumers based on self-report (odds ratio of 0.47, 95% confidence interval [CI] 0.31-0.72) as well as fasting blood glucose (relative risk ratio 0.32, CI 0.17-0.58) and HbA(relative risk ratio 0.51, CI 0.27-0.99). For each standard deviation of increase in walnut intake, prevalence of diabetes dropped 47%. The gender by walnut interaction suggests that the effect may be more potent among women than men (dose response P = .061). CONCLUSIONS: Both among individuals with known diabetes and those diagnosed based on elevated diabetes blood markers, the prevalence of individuals with diabetes was significantly lower among the walnut consumers. A possible gender-specific effect invites further attention.

Thursday, 12 July

23:48

Cepsa to convert alkylation unit Fluoride Action Network

Honeywell has announced that Cepsa will convert an alkylation unit using hydrofluoric acid to Honeywell UOPs solid bed Detal-Plus technology at its refinery in San Roque, Spain.

The unit produces linear alkylbenzene (LAB), which is used to make a variety of different detergent formulations, including biodegradable household detergents.

The Detal-Plus technology is a highly efficient solid bed process for making detergent alkylate, said John Gugel, President of Honeywell UOP. It also has the added benefit of being far simpler to operate.

The technology, which was co-developed with Cepsa, is the first solid bed technology with the flexibility to produce LAB for a variety of different detergent formulations. The heart of the process is Honeywell UOPs new ZDA-30 series catalyst, which features higher activity and selectivity, making it more energy efficient.

In addition to pioneering development of this technology with UOP, Cepsa is the world leader in the manufacture of LAB, said Miguel ngel Caldern, Vice President, Technology at Cepsa. This project allows us to revamp the Puente Mayorga plant at San Roque, so we can enhance its competitiveness, and apply this experience to our other installations around the world.

The Detal-Plus technology, combined with Honeywell UOPs Molex, Pacol, DeFine and PEP processes, forms an integrated and energy-efficient LAB complex. The Molex process provides one of the most economical routes to produce normal paraffins from kerosene. Pacol technology performs dehydrogenation of normal paraffins to olefins, and PEP technology handles the selective removal of aromatics.

*Original article online at https://www.hydrocarbonengineering.com/refining/12072018/ce...

IndyWatch Health Watch Feed Archiver

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

IndyWatch Health Watch Feed was generated at Community Resources IndyWatch.

Resource generated at IndyWatch using aliasfeed and rawdog