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Saturday, 15 December

00:56

My Mother Accidentally Took My Medication Mad In America

It was six in the morning when my brother shook me awake from my sleep.

Get up! Mom just took one of your pills by accident!

I got scared, but I was also too groggy to feel any sort of extreme concern. Its always hard for me to get up early due to the sedation I experience by taking Clozapine, an antipsychotic medication. As much as I wish I could live without it, experience has sadly taught me otherwise. The drug aids in eliminating my voices, tactile hallucinations and paranoid delusions, which otherwise would render me disabled and miserably stifled. With Clozapine, I can work full time as a peer specialist, attend graduate school for social work and freelance as a writer, all simultaneously. Without it, I cycle in and out of hospitals, believing that I am the reincarnation of Beethoven and the Antichrist.

I rolled out of bed and went into the living room, where I saw my mother sitting in her favorite plush chair in front of the television. Her eyes were half-open and she spoke groggily and incoherently as if still half-asleep. On the dining room table were her many bottles of vitamins, which she prepares every morning for the entire day. She takes about 30 supplements daily, which help her greatly in having enough energy to get through the day. I wish natural remedies worked for me.

I accidentally took your Clozapine instead of my Benicar. Benicar is her high blood pressure medication. The 20 mg pill (generic brand) looks almost identical to my 100 mg tab of Clozapine.

I was so scared that she was in grave danger. Would she be permanently damaged from this accidental dose? Instantly I thought of how I myself put 400 mg of Clozapine into my body every day. I thought of my own struggles with grogginess, which causes me to easily sleep 11 hours a day, nearly sleeping half of my life away. I dont feel safe driving a car, so I pay for a lot of Uber cab rides to get to work on time. I felt resentments within me, but then I remembered that no other drug helps me except for Clozapine. Thats typically the case with Clozapine: its prescribed for treatment-resistant schizophrenia.

I need to go to the bathroom.

My mother tried to stand up, but she fell back into her chair. My brother tried to assist her by holding her hand to pull her up, but still her legs were too shaky to stand or walk.

I dont want to pee myself.

My mothers sedated condition reminded me of how Clozapine is not an easy pill to take or manage. I myself started taking it six years ago when I was an inpatient at Zucker Hillside Hospital in Glen Oaks, New York. It took a full six weeks for me to be titrated fully onto a therapeutic-level dose of Clozapine, with psychiatrists monitoring me closely the whole time. The drug is known to cause agranulocytosis for some, re...

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Friday, 14 December

22:48

Heres why you may be aging faster than your friends Health Nut News

By Emilyn Gil Have you ever been mistaken as looking older or younger than your actual age? Or maybe you have friends who were born in the same year as you, but you look years apart? Its not uncommon! RELATED STORY: Perhaps the worst aging myth ever, dont be duped Researchers decided to take this []

The post Heres why you may be aging faster than your friends appeared first on Health Nut News.

22:46

Tiny sun sensor warns you when your skin is about to burn Health Nut News

(Editors Note: I know, I know its winter. However, one can plan ahead! I love winter but there are days when I really miss the sun!) missA miniature wearable sensor has been designed to let you know if youve spent too much or too little time in the sun. RELATED STORY: Lack of sunlight can []

The post Tiny sun sensor warns you when your skin is about to burn appeared first on Health Nut News.

22:38

Running Shoes With Greatest Comfort Promote Highest Injury Risk PreventDisease.com

Highly-cushioned running shoes are meant to protect against injuries, but they may actually do the opposite by changing the way we run, research suggests.

22:16

Kill or Abandon: the Legacy of Denialism of Autism AGE OF AUTISM

DenialWhile we take comfort that Janie Gill did not murder her grandson Guy who has severe autism, the fact that she was compelled to abandon him at a rest stop is enraging. According to the article, she is raising the severely autistic teen because his parents died of drug abuse. Wow. Tragedy all around.  I fear that we these stories will grow in the coming years as cute boys (and girls) with 24/7/365 soup to nuts needs for all tasks of daily living grow into full sized adults. Dirty secret? Our kids are exhausting. My girls, whom I adore, are exhausting. When I am with them, my time is not my own. I am on call, sleeping with one eye open, circling the house like security guard, never, ever at full rest. Not everyone can handle this level of work. I'm not sure how any of us does it. There are few services for severely autistic teens and fewer for adults. Programs are for kids, under 13 is the norm. Yes, I blame Janie Gill for not taking her grandson to a hospital or police station. I also am grateful she did not murder him. That's a hell of a tradeoff. And this is the legacy of autism denialism, as written about by our own Dan Olmsted and Mark Blaxill. Autism can be a severe, debilitating weight on a family.

ROGERS COUNTY, Oklahoma -  A Rogers County grandmother is in jail, accused of dumping her 17-year-old autistic grandson at a Kansas rest stop and leaving him there alone.

Investigators say the boy has the mental capacity of a five-year-old and does not have the ability to communicate. They say he was left with no money, no medication, and no food. They say the only way for him to stay warm was to stay inside the bathroom. They say he was there for 24 hours before Kansas deputies took him to a hospital. They posted his picture on social media and an Oklahoma teacher recognized him.

The boys grandmother, Janie Gill, says shes raising her grandson, Guy after his parents died from drug abuse. She says he's severely disabled and has become a lot harder to deal with since hes gotten bigger. She says shes asked for help, but, hasnt received any.

After the boy was identified, they contacted Gill. They say she told them she'd given the boy to a relative in Ada. Read more at...

22:16

Reddit War Between Moms Over Vaccination: The Vilification of Healthy Children AGE OF AUTISM

Hate FearHere's the nutshell version: A NC Mom uninvited a child to a birthday party because the child is not vaccinated assuming she could sicken another party guest who has a compromised immune system due to cancer treatments. Mad ensued on both sides. How is a healthy child a threat to a child with a compromised immune system? There may have been children who were shedding flu or chicken pox vaccines at the party. Or an adult who had gotten the shingles vaccine.  Were temps taken at the door? Rapid strep tests? Who is the "threat" and why are children being considered "weaponized" because they do NOT have a vaccine? It's part of the troubling trend to demonize vaccine choice. I can't think of one Mom I know who would jeopardize another child willingly. But all children live in a germ and virus filled world. I'd be more afraid of a grocery cart handle or the bathroom stall door at school for my child, than a healthy friend attending a party. Fear breeds hate. Hate breeds violence.

###

A North Carolina mother says that another mom lost her cool after her daughter was uninvited to the first daughter's birthday party due to some very serious health concerns.

A 35-year-old Redditor, who goes by dankmoms on the site, was hosting a birthday party for her seven-year-old daughter when she learned that one of the little girls who'd been invited was not vaccinated.

Unfortunately, her daughter's best friend is a cancer survivor and has a compromised immune system, so getting sick could kill her leading dankmoms to feel compelled to uninvite the unvaccinated child, sparking the fury of that child's mother. Read more here.

...

22:01

BBC Video Shames Those Struggling With Psychiatric Drugs Mad In America

From RxISK.org: James Moore on his Lets Talk Withdrawal site has recently posted the following. The reason to reproduce here is that it seems to overlap so much with the Peter Gtzsche Affair. [] In both instances we have an ex-Collaboration in one case and almost ex-College in another more concerned with their brand and business opportunities than with the integrity of the data or the wellbeing of patients. See what you think.

***

On Tuesday, November 20th, the Royal College of Psychiatrists participated in a video made by the BBC entitled End pill-shaming in mental health. In the video, Hannah describes her experiences of enduring criticism for taking medication and being mentally ill. Also, the RCPsych President, Professor Wendy Burn, shares the story of putting a 70-year-old gentleman onto antidepressants.

I thought that Hannah was brave and eloquent in speaking about her experiences and we can all benefit from hearing real experiences both good and bad. But, dear BBC, where is the balance? Where is the person harmed by the drugs? How can we let the viewers know that there is a range of opinions on this issue? Was anyone from the prescribed harm community even allowed a single comment on the video?

Article 

22:00

Q&A: Dad Is Coercing Son to Get Off Meds Mad In America

Question:

My son was diagnosed with schizophrenia five years ago and now lives in a residential facility with a holistic treatment approach.  He has suffered much but is emerging as a kind and creative guy focused on his treatment (medication, therapy, meditation, sobriety, and health) and working towards his goals.

However, his father has repeatedly and aggressively tried to coerce him to get off medication, telling him that he will only recover if he stops taking them. My son and his provider have repeatedly asked him to stop, and the stress of his fathers pressure is setting him back. What should we do?

Reply from Ben Furman, M.D.:

Years ago, I worked as a psychiatrist in a psychiatric hospital in a rural town here in Finland during the summer months. The nurses there complained to me that there was a small but vigorous religious sect in town that tried to undo their good work by convincing patients to discontinue their medication after their release from the hospital. Following the adage, if you cant beat them, join them, I suggested we organize a celebration at the hospital in honor of our patients and invite their families and community members including the aforementioned sect.

Sure enough, when the celebration took place a couple of weeks later, members of the sect were among the guests. We even granted them permission to sing a few of their chants accompanied by an accordion on the corridor of our ward. That one day made a big difference in our relationship with people we had perceived to be our number-one adversary.

Learning to Listen

There are many beliefs about the best way to help people suffering from mental health crises, and its unlikely that we will ever reach a consensus. The readers of this website are likely to have heard about an increasingly popular treatment approach known as Open Dialogue, which offers a way of allowing differing opinions to be voiced and heard. Everyone has the right to his or her views, and everyones views are acknowledged. When people feel that they have been acknowledged, it becomes easier for them to hear and acknowledge others.

However belligerent your sons father may seem, please be kind to him. Acknowledge his opinion. Perhaps...

22:00

Political scientist asks for correction, gets flip-flop Retraction Watch

Youd think that if an author asked a journal to correct a modest mistake, the journal would oblige. After all, many researchers have to be dragged kicking and screaming to correct the record. But for Ryan Enos, a political scientist at Harvard, self-correction of a paper he had published in the Proceedings of the National Continue reading Political scientist asks for correction, gets flip-flop

16:19

Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats. GreenMedInfo

PMID:  J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID: 30266114 Abstract Title:  Histological Effects of Nigella Sativa on Aspirin-Induced Nephrotoxicity in Albino Rats. Abstract:  OBJECTIVE: To determine the histological effects of Nigella sativa on kidneys against aspirin-induced nephrotoxicity in albino rats.STUDY DESIGN: An experimental study.PLACE AND DURATION OF STUDY: Anatomy Department, University of Health Sciences, Lahore, from January 2014 to December 2015.METHODOLOGY: Thirty-two rats were equally divided into four groups A, B, C and D of eight animals each. Group A (control) was provided with single oral dose of 10 mg/100 gm body weight of 1% methyl cellulose. Group B (experimental group) and C (self recovery group) were provided with single oral dose of 1000 mg/kg aspirin. Group D was provided with 250 mg/kg ethanolic extract of Nigella sativa followed by 1000 mg/kg aspirin by oral gavage, after that only extract of Nigella sativa was given for seven days. Animals of groups A, C and D were sacrificed on the 8th day of experiment and that of group B on the second day of experiment. Kidneys were excised and fixed in 10% formalin solution. Hematoxylin, eosin and periodic acid Schiff's reagents were used to stain the kidney tissues. Histological slides were prepared to study proximal convoluted tubules.RESULTS: Histological parameters were normal in control group A. Significant impairment was present in group B. There was no self-recovery in group C. Significant improvement was present in all the parameters of group D.CONCLUSION: Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.

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16:13

Comparative immunomodulatory activity of Nigella sativa L. preparations on proinflammatory mediators: a focus on asthma. GreenMedInfo

PMID:  Front Pharmacol. 2018 ;9:1075. Epub 2018 Oct 2. PMID: 30333747 Abstract Title:  Comparative Immunomodulatory Activity ofL. Preparations on Proinflammatory Mediators: A Focus on Asthma. Abstract:  A range of traditional and commercial preparations of NS is frequently used in the treatment of several inflammatory diseases. Often, these preparations have poor preclinical characterization that may lead to variable pharmacological effects.To assess theeffects of different chemically defined preparations of NS on some asthma-related mediators of inflammation.Different NS preparations were obtained by either seed extraction with a spectrum of solvents ranging from lipophilic to hydrophilic, or commercial products were collected. The TQ concentration of NS was analyzed by HPLC. Immunomodulatory activity was assessed by the release of mediators (IL-2, IL-6, PGE) in primary human T-lymphocytes, monocytes, and A549 human lung epithelial cells.Ten distinct NS preparations showed variability in TQ concentration, being highest in the oily preparations extract-7 (2.4% w/w), followed by extract-10 (0.7%w/w). Similarly, the release of mediators was varied, being greatest in extract-7 and 10 via significantly (

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15:19

N. sativa could be considered as a potential therapy for asthma therapy and prevention. GreenMedInfo

PMID:  BMC Res Notes. 2018 Oct 19 ;11(1):744. Epub 2018 Oct 19. PMID: 30340634 Abstract Title:  Nigella sativa as an anti-inflammatory agent in asthma. Abstract:  OBJECTIVE: Nigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The laboratory experiment was used to investigate the effectivity of N. sativa as an anti-inflammatory on mast cells. Six groups of mast cells were stimulated by C 48/80 to release histamine. Group 1 were without N. sativa, while group 2, 3, 4, 5, and 6 were given N. sativa with concentrations of 0.1 mg/ml, 0.2 mg/ml, 0.3 mg/ml, 0.4 mg/ml and 0.5 mg/ml, respectively. Histamine concentration was measured by high-performance liquid chromatography-fluorometry.RESULT: The study showed that N. sativa ethanol extract effectively inhibit histamine release from peritoneal Wistar rat mast cells proportionally to its concentration. N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. N. sativa could be considered as a potential therapy for asthma therapy and prevention.

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15:09

The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients. GreenMedInfo

PMID:  Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718800059. Epub 2018 Oct 4. PMID: 30370173 Abstract Title:  Effect ofNasal Spray on the Treatment of Chronic Rhinosinusitis Without a Nasal Polyp. Abstract:  Background: Chronic rhinosinusitis (CRS) is a common inflammatory disease of nasal and paranasal sinuses, with many treatment methods available for the management of this disease. Recently, herbal medicines have shown a significant impact on inflammatory diseases such as CRS, and one of these herbal medicines is. Therefore, the current study aimed to evaluate the effectiveness ofin patients with CRS without nasal polyp (CRSsNP).Methods: In this randomized clinical trial, 65 patients with mild to moderate CRSsNP were enrolled based on the inclusion criteria. Patients were divided randomly into 2 parallel groups: intervention and placebo groups. Patients in the intervention group received 2 puffs/day ofnasal spray (1 g/day of) and in the placebo group received 2 puffs/day of sodium chloride spray 0.65%.Results: Thirty-one patients (19 men and 12 women) in the intervention group and 34 in the placebo group (18 men and 16 women) were evaluated. Lund-McKay, Lund Kennedy, and Sino-Nasal Outcome Test-22 scores were assessed for both groups after 8 weeks of treatments. These scores decreased significantly in both groups. However, these scores were significantly lower in the intervention group compared with the placebo group (

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14:50

Acupuncture improves the facial muscular function in a case of facioscapulohumeral muscular dystrophy. GreenMedInfo

PMID:  J Acupunct Meridian Stud. 2018 Nov 30. Epub 2018 Nov 30. PMID: 30508665 Abstract Title:  Acupuncture improves the facial muscular function in a case of facioscapulohumeral muscular dystrophy. Abstract:  Facioscapulohumeral muscular dystrophy (FSHD) is a genetic muscle disorder in which muscles of the face, shoulder blades and upper arms develop gradual and progressive weakness. There is no effective pharmacological treatment currently available for this disorder so far. We had an opportunity to treat a patient with FSHD using acupuncture. The patient was a 62-year-old female, who presented to us with symptoms as weakness in her eyes, mouth, shoulder, the upper and lower limbs. Muscle atrophy could be found in multiple area in her body including her face, shoulder, arm, chest and lower limbs, etc. Her diagnosis of FSHD muscular dystrophy was established a few years ago and was later genetically confirmed. Following a long treatment course of about 10 months with acupuncture, this patient showed a significant restoration of her facial muscle function. However, acupuncture did not improve the function of other muscle groups. The potential mechanism that acupuncture improved the facial function but not the other muscles needs to be further investigated.

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14:40

Acupuncture may be effective in improving cognitive function in vascular dementia animal models. GreenMedInfo

PMID:  BMC Complement Altern Med. 2018 Nov 13 ;18(1):302. Epub 2018 Nov 13. PMID: 30424749 Abstract Title:  Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis. Abstract:  BACKGROUND: Vascular dementia is the second most common type of dementia that causes cognitive dysfunction. Acupuncture, an ancient therapy, has been mentioned for the treatment of vascular dementia in previous studies. This study aimed to evaluate the effects of acupuncture in animal models of vascular dementia.METHODS: Experimental animal studies of treating vascular dementia with acupuncture were gathered from Embase, PubMed and Ovid Medline (R) from the dates of the databases' creation to December 2016. We adopted the CAMARADES 10-item checklist to evaluate the quality of the included studies. The Morris water maze test was considered as an outcome measure. The software Stata12.0 was used for the meta-analysis. Heterogeneity was examined using Istatistics, and we conducted subgroup analyses to determine the causes of heterogeneity for escape latency and duration in original platform.RESULTS: Sixteen studies involving 363 animals met the inclusion criteria. The included studies scored between 4 and 8 points, and the mean was 5.44. The results of the meta-analysis indicated remarkable differences with acupuncture on increasing the duration in the former platform quadrant both in EO models (SMD=1.56, 95% CI: 1.02 ~2.11; p

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14:14

Electroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis. GreenMedInfo

PMID:  J Pain Res. 2018 ;11:2797-2808. Epub 2018 Nov 8. PMID: 30510442 Abstract Title:  Electroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis. Abstract:  Purpose: Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, with chronic pain as its typical symptom. Although studies have shown that an activated peripheral CB2 receptor can reduce acute pain, whether the CB2 receptor is involved in electroacupuncture (EA) inhibiting chronic pain and the involved mechanism remains unclear. The aim of this study was to investigate whether EA may strengthen peripheral CB2 receptor-inhibited chronic pain in a mouse model of KOA.Materials and methods: KOA was induced by intra-articular injection of monosodium iodoacetate (MIA) into the left knee joint of mice. Thermal hyperalgesia was tested with the hot plate test, and mechanical allodynia was quantified using von Frey filaments. The expression of CB2 receptor and IL-1 were quantified by using immunofluorescence labeling.Results: EA treatment at 2 Hz+1 mA significantly increased the expression of CB2 receptor in fibroblasts and decreased the expression of IL-1 in the menisci compared with that in the KOA group. However, EA had no effect on the expression of IL-1 in CB2mice. At 2 Hz+1 mA, EA significantly increased mechanical threshold, thermal latency, and weight borne after KOA modeling. However, knockout of the CB2 receptor blocked these effects of EA. After 2 Hz+1 mA treatment, EA significantly reduced the Osteoarthritis Research Society International (OARSI) score after KOA modeling. However, EA had no significant effect on the OARSI score in CB2mice.Conclusion: EA reduced the expression of IL-1 by activating the CB2 receptor, thus inhibiting the chronic pain in the mouse model of KOA.

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14:01

Acupuncture could alleviate allergic airway inflammation by strengthening the activities of Th1 and Treg. GreenMedInfo

PMID:  Chin J Integr Med. 2018 Dec 5. Epub 2018 Dec 5. PMID: 30519873 Abstract Title:  Acupuncture Regulates the Balance of CD4T Cell Subtypes in Experimental Asthma Mice. Abstract:  OBJECTIVE: To evaluate the involvement of different CD4T cell subtypes in the anti-asthmatic effects of acupuncture in asthmatic mice.METHODS: BALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. Mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Acupoints Dazhui (GV 14), bilateral Fengmen (BL 12) and Feishu (BL 13) were selected for manual acupuncture treatment every other day for 4 weeks and Huantiao (GB 30) was selected for sham acupuncture. Airway hyperresponsiveness was examined by Buxco Pulmonary System. Pulmonary histopathology analysis was performed for inflammatory cell infiltration and mucus hypersecretion by haematoxylin eosin staining and periodic acid-Schiffstaining. Inflammatory mediators assays of serum were investigated by enzyme-linked immunosorbent assay and Bio-Plex. CD4T cell subpopulations including the expression levels of important factors in T lymphocyte polarization in lung tissue were examined by flow cytometric and Western blot analyses. Related pathways were detected by Western blot assay.RESULTS: Compared with the OVA-induced asthma model group, acupuncture could attenuate airway hyperresponsiveness, inhibit inflammatory cell infiltration and mucus hypersecretion (P

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13:53

The present meta-analysis indicated that acupuncture can help to improve insulin resistance to a certain extent. GreenMedInfo

PMID:  Curr Med Sci. 2018 Dec ;38(6):1109-1116. Epub 2018 Dec 7. PMID: 30536077 Abstract Title:  Is Acupuncture Effective for Improving Insulin Resistance? A Systematic Review and Meta-analysis. Abstract:  This study aimed to evaluate the clinical efficacy of acupuncture for intervening insulin resistance (IR) by meta-analysis of related randomized controlled trials (RCTs). Studies published prior to 31 January 2018 were searched on Pubmed, Medline, Cochrane Library, Embase databases and Chinese databases. Only RCTs, which examined acupuncture as the sole or adjunctive treatment for IR-related diseases, were included. The primary outcome was homeostasis model assessment for insulin resistance (HOMA-IR). The secondary outcomes consisted of fasting blood glucose (FBG), fasting insulin (FINS) and 2-h postprandial blood glucose (2h-PBG). The differences between groups were reported as mean differences (MD). All statistical analyses were performed using RevMan software 5.3. After carefully screening relevant studies, 9 RCTs involving 562 patients (279 in experimental group and 283 in control group) were enrolled in this study. The pooled results showed that acupuncture had significant effects on HOMA-IR (MD 0.70, 95% CI 0.04 to 1.35, P=0.04

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13:41

Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis. GreenMedInfo

PMID:  Hepatobiliary Pancreat Dis Int. 2018 Nov 22. Epub 2018 Nov 22. PMID: 30527903 Abstract Title:  Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis. Abstract:  BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. Gut microbiota has been demonstrated to play a critical role in liver inflammation, chronic fibrosis, liver cirrhosis, and HCC development through the gut-liver axis.DATA SOURCES: Recently there have been several innovative studies investigating gut microbial dysbiosis-mediated enhancement of HCC through the gut-liver axis. Literatures from January 1998 to January 2018 were searched in the PubMed database using the keywords"gut microbiota"and"hepatocellular carcinoma"or"liver cancer", and the results of experimental and clinical studies were analyzed.RESULTS: Gut microbial dysbiosis accompanies the progression of alcoholic liver disease, non-alcoholic fatty liver disease and liver cirrhosis, and promotes HCC progression in an experimental mouse model. The immune system and key factors such as Toll-like receptor 4 are involved in the process. There is evidence for gut microbial dysbiosis in hepatitis virus-related HCC patients.CONCLUSIONS: Gut microbial dysbiosis is closely associated with hepatic inflammation disease and HCC through the gut-liver axis. With the enhanced understanding of the interactions between gut microbiota and liver through the gut-liver axis, new treatment strategies for HCC are being developed.

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13:31

Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess. GreenMedInfo

PMID:  Aliment Pharmacol Ther. 2018 Mar ;47(6):801-808. Epub 2018 Jan 12. PMID: 29327781 Abstract Title:  Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess. Abstract:  BACKGROUND: Proton pump inhibitors (PPI) are often used in patients with gastro-esophageal reflux and peptic ulcer disease. A higher risk for infectious diseases and for pyogenic liver abscess has been reported in patients with prolonged PPI intake. Although many patients have ongoing PPI treatment after diagnosis of liver abscess, there are no data available that focus on the prognostic impact of PPI treatment in these patients.AIM: To analyse the effect of PPI treatment on mortality in patients with pyogenic liver abscesses.METHODS: Between January 2005 and March 2017, one hundred and eighty-one patients with pyogenic liver abscess were retrospectively included in this analysis. Medical records including PPI treatment, microbiological and imaging data were reviewed. The primary endpoint was index mortality and predictive factors were analysed using uni- and multivariate logistic regression models.RESULTS: One hundred patients with pyogenic liver abscess (55.2%) were treated with PPI compared to 81 patients (44.8%) without PPI treatment. In both patient cohorts, enterococcus spp. and streptococcus of the anginous group were the most common pathogens identified. Patients with PPI treatment had significantly higher index mortality compared to patients without PPI treatment (30.0% vs 11.1%, P = 0.003). After adjusting for comorbidities PPI remained an independent predictive factor with an OR of 2.56 (1.01-6.46, P = 0.036).CONCLUSIONS: PPI treatment is associated with higher index mortality in patients with pyogenic liver abscess. Therefore, critical evaluation of the indication for PPI treatment is particularly important in patients at high risk for pyogenic liver abscess.

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13:26

Proton pump inhibitors increase the susceptibility of mice to oral infection with enteropathogenic bacteria. GreenMedInfo

PMID:  Dig Dis Sci. 2018 04 ;63(4):881-889. Epub 2018 Jan 11. PMID: 29327263 Abstract Title:  Proton Pump Inhibitors Increase the Susceptibility of Mice to Oral Infection with Enteropathogenic Bacteria. Abstract:  BACKGROUND AND AIMS: Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in this study, we explored whether Lansoprazole (Laz), one of the PPIs, increases the susceptibility to enteropathogens, and further investigated the mechanism of it.METHODS: Mice were administered Laz intraperitoneally once daily and orally infected with Citrobacter rodentium (C. rodentium). The establishment of intestinal infection was assessed by histology and inflammatory cytokine expression levels measured by quantitative PCR. To test whether Laz changes the intestinal environment to influence the susceptibility, intestinal pH, microbiota, metabolites and immune cell distributions were evaluated via pH measurement, 16S rRNA gene sequencing, metabolome, and flow cytometry analyses after Laz administration.RESULTS: Colitis was induced with less C. rodentium in Laz-treated mice as compared with the controls. We found that increased numbers of C. rodentium could reach the cecum following Laz administration. Laz increased pH in the stomach but not in the intestines. It induced dysbiosis and changed the metabolite content of the small intestine. However, these changes did not lead to alterations of immune cell distribution.CONCLUSIONS: Laz raised susceptibility to C. rodentium as increased numbers of the pathogen reach the site of infection. Our results suggest that it was due to increased stomach pH which allowed more peroral enteropathogens to pass the stomach, but not because of changes of intestinal environment.

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13:02

This review summarizes the possible mechanisms connecting the use of proton-pump inhibitors and the incidence of Alzheimer's disease. GreenMedInfo

PMID:  Curr Med Chem. 2018 ;25(18):2166-2174. PMID: 29376492 Abstract Title:  Is the Use of Proton-pump Inhibitors a Risk Factor for Alzheimer's Disease? Molecular Mechanisms and Clinical Implications. Abstract:  Proton-pump inhibitors (PPIs), such as omeprazole, lansoprazole and rabeprazole, are used for the treatment of gastroesophageal reflux disease and peptic ulcer disease. The use of PPIs has increased, especially in older individuals, and a pharmacoepidemiological study indicated the use of PPIs peaks in people aged 80 years or older. In this population, Alzheimer's disease (AD) is a common neurological disorder and type of dementia, occurring with a frequency of approximately 10%. Currently, over 45 million people are estimated to have dementia worldwide, and it is a major cause of death in the elderly. Recent clinical studies have indicated that chronic use of PPIs can be a risk factor for increased incidence of dementia, including AD. Potential molecular mechanisms related to the pathophysiology of AD (e.g., modulation of amyloid protein processing) have also been reported in both in vitro and in vivo studies. Although the clinical implications of these results are inconclusive, a literature review of the current knowledge is important for future basic and clinical research. This review summarizes the possible mechanisms connecting the use of PPIs and the incidence of AD. Additionally, we summarize results from clinical studies to highlight the influence in humans.

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12:58

Long term use of proton pump inhibitors is associated with increased risk of oesophageal adenocarcinoma in the absence of other risk factors. GreenMedInfo

PMID:  Cancer Epidemiol. 2018 04 ;53:172-177. Epub 2018 Feb 22. PMID: 29477057 Abstract Title:  Maintenance proton pump inhibition therapy and risk of oesophageal cancer. Abstract:  BACKGROUND: The association of long-term use of proton pump inhibitors (PPIs) with oesophageal adenocarcinoma has been poorly defined. Our aim was to assess the risk of oesophageal cancer assessing confounding by indication.METHODS: This population-based cohort study included all 796,492 adults exposed to maintenance therapy with PPIs in Sweden in 2005-2012. Standardised incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated to assess the risk of oesophageal adenocarcinoma (and squamous cell carcinoma as a comparison) among long-term PPI users relative to the corresponding background population. The different indications for maintenance PPI therapy were analysed separately.RESULTS: Among all individuals using maintenance PPI therapy, the overall SIR of oesophageal adenocarcinoma was 3.93 (95% CI 3.63-4.24). The SIRs of adenocarcinoma were increased also among individuals without gastro-oesophageal reflux disease who used PPIs for indications not associated with any increased risk of oesophageal adenocarcinoma. For example, the SIRs among participants using maintenance PPI therapy because of maintenance treatment with non-steroidal anti-inflammatory drugs and aspirin were 2.74 (95% CI 1.96-3.71) and 2.06 (95% CI 1.60-2.60), respectively. The SIRs of oesophageal squamous cell carcinoma were increased for most investigated indications, but to a lesser degree than for oesophageal adenocarcinoma.CONCLUSION: In conclusion, the long term use of PPIs is associated with increased risk of oesophageal adenocarcinoma in the absence of other risk factors. Long term use of PPIs should be addressed with caution.

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12:18

Patients with rheumatoid arthritis found a significantly increased risk of acute kidney injury associated with the use of proton pump inhibitors. GreenMedInfo

PMID:  Drug Saf. 2018 08 ;41(8):817-826. PMID: 29603109 Abstract Title:  Use of Proton Pump Inhibitors and the Risk of Acute Kidney Injury Among Patients with Rheumatoid Arthritis: Cohort Study. Abstract:  INTRODUCTION: Recent observational studies have indicated that use of proton pump inhibitors may be associated with adverse renal outcomes. The objective of this study was to investigate whether the use of proton pump inhibitors increases the risk of acute kidney injury among patients with rheumatoid arthritis.METHODS: We conducted the study as a historical prospective cohort study, including patients with rheumatoid arthritis, 30-84 years of age, during 2004-2015. Among these, we identified and matched episodes of use and non-use of proton pump inhibitors (control episodes) 1:4 on the propensity score, including 24,579 episodes of use of proton pump inhibitors and 98,230 control episodes. The primary outcome was a first diagnosis of acute kidney injury and the secondary outcome was any serious renal event (acute kidney injury or chronic kidney disease). The primary time point for analysis was 120 days after study entry.RESULTS: The incidence rate of acute kidney injury was 2.2 per 1000 person-years during episodes of use of proton pump inhibitors and 0.9 during control episodes. Use of proton pump inhibitors was associated with a significantly increased risk of acute kidney injury (hazard ratio 2.30, 95% confidence interval 1.26-4.20). The absolute risk difference was 40 (95% confidence interval 8-99) events of acute kidney injury per 100,000 episodes of use of proton pump inhibitors. Use of proton pump inhibitors was also associated with a significantly increased risk of the secondary outcome of any serious renal event (hazard ratio 2.61, 95% confidence interval 1.80-3.80).CONCLUSIONS: This cohort study among patients with rheumatoid arthritis found a significantly increased risk of acute kidney injury associated with the use of proton pump inhibitors. These findings may help inform clinical decision making when considering the risks and benefits of proton pump inhibitor treatment in rheumatoid arthritis.

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12:09

A review of the side effects of long-term proton pump inhibitor use. GreenMedInfo

PMID:  Basic Clin Pharmacol Toxicol. 2018 Aug ;123(2):114-121. Epub 2018 May 24. PMID: 29658189 Abstract Title:  Side Effects of Long-Term Proton Pump Inhibitor Use: A Review. Abstract:  Proton pump inhibitors (PPIs) are widely used, and concerns about overuse have been raised. Therefore, side effects are important to be aware of and several suggested side effects of long-term use have been studied. In this MiniReview, we sum up the evidence of side effects related to long-term PPI treatment. Suspected side effects are mainly related to increased susceptibility to infections, secondary hypergastrinaemia, impeded absorption of micronutrients or idiosyncratic reactions. Most of the potential side effects have only been evaluated in observational studies demonstrating conflicting and weak associations with a substantial risk of confounding. However, a high probability of causality seems to be established for the side effects increased risk of gastrointestinal infections and rebound acid hypersecretion following discontinuation of treatment due to secondary hypergastrinaemia. The risk of side effects should not be a reason to withhold PPIs from patients with a true indication, and worry about poorly proven side effects should not lead to unnecessary discontinuation. The most important safety issue regarding PPI therapy is to critically evaluate the indication when initiating treatment and reconsidering the indication in long-term-treated patients.

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12:02

OCD: A New Study Says It Isnt Your Fault. So Quit Hiding (and get help)! Chipur

A stunning number of OCD sufferers choose to stay undercover. Oh, I suspect the perceived "freak" factor is at play, along with guilt and shame. Hey, here's a brand new study that says none of us are at fault. So quit hiding, okay? And get some help...

12:01

These results showed that gut dysbiosis was caused by proton pump inhibitor use. GreenMedInfo

PMID:  Dig Dis Sci. 2018 11 ;63(11):2940-2949. Epub 2018 May 24. PMID: 29796911 Abstract Title:  Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors. Abstract:  BACKGROUND: Recently, problems associated with proton pump inhibitor (PPI) use have begun to surface. PPIs influence the gut microbiota; therefore, PPI use may increase the risk of enteric infections and cause bacterial translocation. In this study, we investigated fecal microbiota composition, fecal organic acid concentrations and pH, and gut bacteria in the blood of the same patients before and after PPI use.METHODS: Twenty patients with reflux esophagitis based on endoscopic examination received 8 weeks of treatment with PPIs. To analyze fecal microbiota composition and gut bacteria in blood and organic acid concentrations, 16S and 23S rRNA-targeted quantitative RT-PCR and high-performance liquid chromatography were conducted.RESULTS: Lactobacillus species were significantly increased at both 4 and 8 weeks after PPI treatment compared with bacterial counts before treatment (P=0.011 and P=0.002, respectively). Among Lactobacillus spp., counts of the L. gasseri subgroup, L. fermentum, the L. reuteri subgroup, and the L. ruminis subgroup were significantly increased at 4 and 8 weeksafter treatment compared with counts before treatment. Streptococcus species were also significantly increased at 4 and 8 weeks after PPI treatment compared with counts before treatment (P

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11:48

Proton pump inhibitors may cause gastric cancer. GreenMedInfo

PMID:  Scand J Gastroenterol. 2018 06 ;53(6):639-642. Epub 2018 May 31. PMID: 29852782 Abstract Title:  Proton pump inhibitors (PPIs) may cause gastric cancer - clinical consequences. Abstract:  Recently, two epidemiological studies showed that long-term treatment with proton pump inhibitors (PPIs) increased the risk of gastric cancer. It is well known that hypergastrinemia predisposes to gastric neoplasia in animals as well as man. Recently a study showed that hypergastrinemic patients had an increased risk of gastric cancer when followed for about 25 years. It is likely that hypergastrinemia is the pathogenic factor for gastric carcinogenesis due to PPI. PPI are the only group of drugs that causes long-term hypergastrinemia in the doses used in a clinical setting. Due to the likely carcinogenic effect, PPIs should be used carefully. Moreover, since the carcinogenic effect of Helicobacter pylori (Hp) infection also may be mediated by an increase in gastrin, Hp should be eradicated whenever treatment with PPI is initiated. In peptic ulcer disease Hp eradication is the treatment of choice. Gastro-oesophageal reflux disease (GERD) is the most prevalent condition leading to long-term use of inhibitors of gastric acid secretion. Only in severe oesophagitis should the treatment be initiated by PPIs, whereas histamine-2 (H-2) blockers ought to be the initial option in most cases of GERD particularly since PPI treatment induces tolerance to H-2 blockers. In the cases where long-term PPI treatment is necessary, the dose should be adjusted by the determination of chromogranin A, which in a way reflects 24-h gastrin exposure. Finally, due to latency of neoplasia, the use of PPI must be very restricted in children and young adults.

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11:16

Long-term proton pump inhibitors use is associated with risk of bone complications. GreenMedInfo

PMID:  Tunis Med. 2018 Mar ;96(3):193-197. PMID: 30325487 Abstract Title:  Effect of long-term proton pump inhibitors on bone mineral density. Abstract:  BACKGROUND: Proton pump inhibitors (PPIs) are widespread nowadays. Recent concerns haveemerged about possible bone complications of their long-term use, as lowbone mineral density (BMD) and an increased risk of fractures.AIM: To evaluate the effect of long-term use of PPIs on boneby estimating the frequency of osteopenia andosteoporosis, and determining the risk factors associated to these complications.METHODS: A prospective study including consecutive patients taking PPI for at least one year. All patients underwent bonedensitometry, and  FRAXscore was calculated to estimate the risk of osteoporotic fracture.RESULTS: We included 52 patients with a mean age of 49.5 years and a male-femaleratio of 0,48. Mean duration of PPI intake was 45 months. The most frequentindication was gastroesophageal reflux disease.  PPI prescription wasappropriate in 94% of cases. The calculated daily calcium intake was in majority insufficient (94%).  Approximately half of patients had at least three risk factors. Osteopenia and osteoporosiswere observed in 52% and 19% respectively. Predictive factors of low BMD were an age50 years, menopause, calcium intake 550mg/day and a PPI use duration30 months. FRAX score was significantly higher when BMD was lower. The multivariate analysis could not be undertaken because of co linearity of the factors.CONCLUSION: Long-term PPI use is associated with risk of bone complications, especiallyamong patients at risk for osteoporosis. It seems reasonable to be more vigilantin prescribing PPIs and to use the lowest effective dose for patients with appropriateindications.

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11:11

Proton pump inhibitors use is associated with a higher risk of incident chronic kidney disease. GreenMedInfo

PMID:  PLoS One. 2018 ;13(10):e0204231. Epub 2018 Oct 17. PMID: 30332411 Abstract Title:  Duration and dosing of Proton Pump Inhibitors associated with high incidence of chronic kidney disease in population-based cohort. Abstract:  BACKGROUND: Proton Pump Inhibitors (PPIs) have been associated with chronic kidney disease (CKD). Our objective was to quantify the association between PPI use and incident CKD in a population-based cohort.METHODS AND FINDINGS: We used a population-based retrospective cohort, including people aged 15 years or over, between January 1, 2005 and December 31, 2012. PPI use was measured in a follow-up session by recording prescriptions. Incident CKD was defined as an estimated glomerular filtration rate

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10:55

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers. GreenMedInfo

PMID:  J Gastroenterol Hepatol. 2018 Nov 8. Epub 2018 Nov 8. PMID: 30408229 Abstract Title:  Helicobacter pylori increases the risk of low-dose aspirin ulcers: A meta-analysis. Abstract:  BACKGROUND AND AIM: Owing to wide-spread use, low-dose aspirin (LDA) produces a substantial amount of peptic ulcer disease. Current guidelines are ambivalent about the need for Helicobacter pylori eradication to protect against LDA ulcers. This study aimed to determine, through meta-analysis, if (and by how much) infection alters the baseline risk of peptic ulcers during LDA therapy.METHODS: Literature screening was performed in MEDLINE and EMBASE from inception to May 2018. Original studies reporting prevalence or incidence of uncomplicated ulcers in LDA users were included. Ulcer endpoints needed to be specified separately, according to Helicobacter pylori infection status. Meta-analysis was performed in MIX 2.0 Pro.RESULTS: Ten cross-sectional studies and seven randomized controlled trials were included (n = 5964). The pooled odds ratios (OR) with 95% confidence intervals (CI) for the risk of LDA ulcers in Helicobacter pylori-positive vs. -negative individuals were 1.68 (95%CI 1.40-2.02) and 1.65 (95%CI 1.29-2.08) under fixed- and random-effects models, respectively. Heterogeneity among studies was minimal (I= 26.9%). After adjusting for the protective effects of antisecretory drugs, the OR increased to 1.94 (95%CI 1.54-2.46).CONCLUSION: This analysis suggests Helicobacter pylori increases the risk of LDA ulcers by almost 70% in a population where some were taking proton pump inhibitors and/or other acid suppressants. Without antisecretory drugs, the risk almost doubles. Clinically, these findings may support the use of a test-and-treat approach to Helicobacter pylori in LDA users, particularly those at higher risk of developing for peptic ulcers.

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10:38

Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients. GreenMedInfo

PMID:  Diabetes Res Clin Pract. 2018 Nov 27 ;147:67-75. Epub 2018 Nov 27. PMID: 30500543 Abstract Title:  Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients. Abstract:  AIMS: Chronic kidney disease consumes a huge amount of medical resources and proton pump inhibitors may be a potential factor for the increasing prevalence. This population-based cohort study investigates the risk of chronic kidney disease in a diabetic population using proton pump inhibitors in Taiwan.METHODS: This study is based on a specific diabetic database obtained from the National Health Insurance Research Database. Individuals with a new diagnosis of diabetes from 2002 to 2013 were enrolled."Exposure"to proton pump inhibitors was defined as at least one prescription and dosage over 180 DDD (defined daily dose) in one year after the index date. A multivariable Cox proportional hazard model and competing-risk regression model were applied.RESULTS: There were 5994 patients in the final cohort of proton pump inhibitor users and 23,976 patients in the matched controlled cohort based on 1:4 propensity score matching. Compared with no exposure users, PPIs exposure group had more anemia prevalence, anti-hypertension medication and NSAIDs prescriptions. The multivariable Cox proportional hazard model showed that the adjusted hazard ratio of chronic kidney disease was 1.52 (95% CI 1.40-1.65) in diabetic individuals with PPIs exposure, compared with no exposure users.CONCLUSIONS: Proton pump inhibitors use is associated with 1.52-fold increased risk of chronic kidney disease in diabetic patients when the dosage is over 180 DDD in one year in Taiwan.

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10:07

Proton pump inhibitors use is significantly associated with an increased risk of hip fracture development. GreenMedInfo

PMID:  Osteoporos Int. 2018 Dec 12. Epub 2018 Dec 12. PMID: 30539272 Abstract Title:  Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies. Abstract:  : We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1.14-1.28, p

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09:53

Proton-pump inhibitors, corticosteroid and antipsychotic drugs was independently associated with an increased risk for community-acquired pneumonia. GreenMedInfo

PMID:  Expert Opin Drug Saf. 2018 Oct ;17(10):991-1003. Epub 2018 Sep 17. PMID: 30196729 Abstract Title:  Drugs that increase the risk of community-acquired pneumonia: a narrative review. Abstract:  Community-acquired pneumonia (CAP), a major cause of morbidity and mortality, is the leading infectious cause of death in the developed world. Population-based studies and systematic reviews have identified a large number of risk factors for the development of pneumonia in adults. In addition to age, lifestyle habits, and comorbidities, some forms of pharmacotherapy may also increase the risk for CAP. Areas covered: MEDLINE, CENTRAL, and Web of Science were used in 2017 to search for case-control, cohort studies, as well as randomized controlled trials and meta-analysis that involved outpatient proton pump inhibitors (PPIs), inhaled corticosteroids (ICSs), antipsychotics, oral antidiabetics, and CAP diagnosis in patients aged>18 years. Expert opinion: Our review confirmed that the use of ICSs, PPIs or antipsychotic drugs was independently associated with an increased risk for CAP. We also identified a positive association between specific oral antidiabetics and the development of pneumonia.

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09:45

CDCs Own Data Support Link Between MMR Vaccine and Autism Health Impact News

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Re-analysis of CDC Data on MMR Vaccine and Autism

by Focus for Health

After four long years, Dr. Brian Hookers reanalysis of the CDCs MMR-autism data from the original Destefano et al. 2004 Pediatrics paper has been republished in the Winter 2018 Edition of the Journal of American Physicians and Surgeons.

The data, when properly analyzed, using the CDCs own study protocol, show a strong, statistically significant relationship between the timing of the first MMR vaccine and autism, specifically in African American males. In addition, a relationship also exists in the timing of the MMR vaccine and those individuals who were diagnosed with autism without mental retardation.

These relationships call into question the conclusion of the original Destefano et al. 2004 paper which dismissed a connection between the MMR vaccine and autism.

Read the reanalysis paper

Press Release

Association of American Physicians and Surgeons 1601 N. Tucson Blvd. Suite 9
Tucson, AZ 85716
(800) 635-1196
www.aapsonline.org

Dec 7, 2018

Contact: Brian Hooker, Ph.D., drbrianhooker@gmail.com, or Jane M. Orient, M.D., (520) 323-3110, janeorientmd@gmail.com

Re-analysis of CDC Data Suggests Need for Further Investigation on MMR Vaccine and Autism, according to Article in the Journal of American Physicians and Surgeons

Tucson, Ariz. As early as 2001, the Centers for Disease Control and Prevention (CDC) had data showing an increased rate of autism diagnoses in black male schoolchildren in Atlanta who received their first measles-mumps-rubella (MMR) vaccination before 36 months of age, compared with those who received it later, writes Brian Hooker, Ph.D., in the winter issue of the Journal of American Physicians and Surgeons. The relationship loses its statistical significance if the analysis is restricted to children with a Georgia birth certificate, which decreases the sample size by about 40 percent.

Dr. Hooker reanalyzed the same data set, using the same methodology of conditional logistic regression. Children la...

09:39

A review of Antipsychotics and cardiovascular risks. GreenMedInfo

PMID:  Psychiatry Res. 2018 Dec ;270:341-347. Epub 2018 Sep 18. PMID: 30292087 Abstract Title:  Antipsychotics and cardiovascular risk: A case/non-case study. Abstract:  Severe mental disorders have been reported to be associated with an increased cardiovascular risk. To measure the potential risk excess as compared, not with the baseline cardiovascular risk for the general population, but with the cardiovascular risk associated with drug iatrogenia. 197 reported cases of cardiovascular adverse reaction to antipsychotic drugs as compared to the reported cases of this type of adverse reactions to drugs other than antipsychotics entered in the Spanish Pharmacovigilance System database (FEDRA) (1995-2018) in an observational case/non-case study. Risk estimates of association were reporting odds ratio (ROR), and, chi-square test (). Overall disproportionality for the whole drug class was found [ROR 2.3 (95% CI 2.0-2.7)],=127.07]. When the two types of antipsychotics (typical and atypical) were analysed separately, we also found statistically significant disproportionality, and this disproportionality is similar between both groups, with disproportionality measures around 2.30, with the confidence intervals not including the 1. The disproportionality observed suggests a risk excess that might be greater than expected, which holds particularly true for torsade de pointes, sudden death and cardiac arrhythmias in patients treated with any of the two types of antipsychotics. There was no significant risk forischaemic heart disease.

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09:36

Olanzapine may exacerbate atherosclerosis by deregulating hepatic lipid metabolism and worsening hyperlipidemia and aortic inflammation. GreenMedInfo

PMID:  Cell Physiol Biochem. 2018 ;50(4):1216-1229. Epub 2018 Oct 24. PMID: 30355932 Abstract Title:  Atypical Antipsychotic Drug Olanzapine Deregulates Hepatic Lipid Metabolism and Aortic Inflammation and Aggravates Atherosclerosis. Abstract:  BACKGROUND/AIMS: Olanzapine, an atypical antipsychotic drug, has therapeutic effects for schizophrenia. However, clinical reports indicate that patients taking atypical antipsychotic drugs are at high risk of metabolic syndrome with unclear mechanisms. We investigated the effect of olanzapine on atherosclerosis and the mechanisms in apolipoprotein E-null (apoE-/-) mice.METHODS: ApoE-/- mice were used as in vivo models. Western blot analysis was used to evaluate protein expression. Conventional assay kits were applied to assess the levels of cholesterol, triglycerides, free cholesterol, cholesteryl ester, fatty acids, glycerol, and cytokines.RESULTS: Daily treatment with olanzapine (3 mg/kg body weight) for four weeks increased mean arterial blood pressure and the whitening of brown adipose tissue in mice. In addition, olanzapine impaired aortic cholesterol homeostasis and exacerbated hyperlipidemia and aortic inflammation, which accelerated atherosclerosis in mice. Moreover, lipid accumulation in liver, particularly total cholesterol, free cholesterol, fatty acids, and glycerol, was increased with olanzapine treatment in apoE-/- mice by upregulating the expression of de novo lipid synthesis-related proteins and downregulating that of cholesterol clearance- or very low-density lipoprotein secretion-related proteins.CONCLUSION: Olanzapine may exacerbate atherosclerosis by deregulating hepatic lipid metabolism and worsening hyperlipidemia and aortic inflammation.

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09:02

A large proportion of patients with bipolar affective disorder on antidepressants experience medication-induced manic or hypomanic switch. GreenMedInfo

PMID:  S Afr J Psychiatr. 2018 ;24:1215. Epub 2018 Nov 6. PMID: 30473882 Abstract Title:  Risk of manic switch with antidepressants use in patients with bipolar disorder in a Nigerian neuropsychiatric hospital. Abstract:  Background: Depressive disorders are common among those with bipolar affective disorder (BAD) and may necessitate the use of antidepressants. This has been suggested to precipitate manic episodes in some patients.Objectives: This study aims to determine the prevalence of and factors associated with manic switch in patients with BAD being treated with antidepressants.Methods: Case notes of patients who were treated at a Nigerian neuropsychiatric hospital for a BAD from 2004 to 2015 were reviewed. BAD diagnosis was made using ICD-10 criteria. Treatment for bipolar depression included monotherapy (i.e. antidepressants, antipsychotics or mood stabilisers) or combination therapy (mood stabiliser with an antidepressant or a combination of mood stabilisers, antipsychotics and antidepressants). The primary outcome measure was a switch to mania or hypomania within 12 weeks of commencing an antidepressant.Results: Manic or hypomanic switch (MS) was observed in 109 (44.3%) of the participants. Female gender, younger age, number of previous episodes and a past history of psychiatric hospitalisation were all significantly associated with a risk of MS. There was no significant difference in the rate of MS in either those treated with adjunct antidepressants therapy with a mood stabiliser or an antipsychotic or those placed on a combination of antidepressants, antipsychotics and mood-stabilising agents.Conclusion: A large proportion of patients with BAD on antidepressants experience medication-induced manic or hypomanic switch.

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08:51

Trazodone is not a uniformly safer alternative to atypical antipsychotics, given the similar risk of falls and fractures among older adults with dementia. GreenMedInfo

PMID:  CMAJ. 2018 Nov 26 ;190(47):E1376-E1383. PMID: 30478215 Abstract Title:  Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study. Abstract:  BACKGROUND: Trazodone is increasingly prescribed for behavioural and psychological symptoms of dementia, but little is known about its risk of harm. Our objective was to describe the comparative risk of falls and fractures among older adults with dementia dispensed trazodone or atypical antipsychotics.METHODS: The study cohort included adults with dementia (excluding patients with chronic psychotic illnesses) living in long-term care and aged 66 years and older. Data were obtained from routinely collected, linked health administrative databases in Ontario, Canada. We compared new users of trazodone with new users of atypical antipsychotics (quetiapine, olanzapine or risperidone) between Dec. 1, 2009, and Dec. 31, 2015. The primary outcome was a composite of fall or major osteoporotic fracture within 90 days of first prescription. Secondary outcomes were falls, major osteoporotic fractures, hip fractures and all-cause mortality.RESULTS: We included 6588 older adults dispensed trazodone and 2875 dispensed an atypical antipsychotic, of whom 95.2% received a low dose of these medications. Compared with use of atypical antipsychotics, use of trazodone was associated with similar rates of falls or major osteoporotic fractures (weighted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.73 to 1.07), major osteoporotic fracture (weighted HR 1.03, 95% CI 0.73 to 1.47), falls (weighted HR 0.91, 95% CI 0.75 to 1.11) and hip fractures (weighted HR 0.92, 95% CI 0.59 to 1.43). Use of trazodone was associated with a lower rate of mortality (weighted HR 0.75, 95% CI 0.66 to 0.85).INTERPRETATION: Trazodone is not a uniformly safer alternative to atypical antipsychotics, given the similar risk of falls and fractures among older adults with dementia.

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08:47

Prescribing of antipsychotic drugs for dementia or for other mental health care should be avoided. GreenMedInfo

PMID:  J Alzheimers Dis Rep. 2018 Feb 2 ;2(1):1-26. Epub 2018 Feb 2. PMID: 30480245 Abstract Title:  Increased All-Cause Mortality by Antipsychotic Drugs: Updated Review and Meta-Analysis in Dementia and General Mental Health Care. Abstract:  It is almost ten years since the Banerjee 2009 report established that inappropriate prescribing of antipsychotics in the elderly was occurring in the UK and such patients had an 85% increased risk of adverse events and greater mortality. This report was a critical analysis addressing the outcomes of treatment practices for dementia in UK patients and globally, aimed at reducing prescribing of antipsychotic drugs for dementia. Since 2009, many significant studies worldwide (including several more recent large retrospective studies) provide more extensive longitudinal data for the adverse impacts of antipsychotic drugs in dementia. We have used the data in these studies including from over 380,000 dementia patients, with 85,069 prescribed antipsychotic agents as well as from 359,235 non-dementia antipsychotic drug users to provide an up-dated meta-analysis. This is the first meta-analysis to include evidence from general mental health studies showing that antipsychotic drugs precipitate excessive mortality across the spectrum. Prescribing of antipsychotic drugs for dementia or for other mental health care should be avoided and alternative means sought for handling behavioral disorders of such patients.

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08:44

Banned for Use in War, But OK for Our Crops Health Impact News

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By 

Apparently the Geneva Convention doesnt protect against use in domestic agriculture. Action Alert!

Researchers who recently examined studies sponsored by Dow Chemical and used by the EPA to approve chlorpyrifos, a type of insecticide, found inaccuracies in what the company reported to the agency.

Worse, there is also evidence that EPA scientists pointed out these failings to agency officials, but were ignored. It is another example of industry using the power of the federal government to put profits before public health.

The researchers found that the lab used a two percent cut off to determine what was statistically significant through most of the study, instead of the customary 5 percentmeaning it would be more likely that exposure to chlorpyrifos would appear safe. The rat studies submitted to the EPA also did not model human exposure and potential brain impacts, among other failures.

To make matters worse, it appears that agency officials were warned by EPA toxicologists of the studys problems. A memo sent to EPA management said that The study was graded unacceptable due to an inadequate presentation of the statistical data analysis.

Keep in mind, too, that the EPA is aware of evidence that found exposure to chlorpyrifos caused measurable differences in childrens brain function, on average dropping their IQs a few points.

Some research has linked the pesticides to autism and other brain disorders. Theres also evidence to suggest that some children are more vulnerable to the chemicals than others due to their genetic makeup.

These health effects should come as no surprise when we consider that chlorpyrifos were developed as a nerve gas during World War II by the Nazis, though they werent used in battle.

Chemical weapons were prohibited by the Geneva Convention after WWIso the chemical is too...

08:31

There was an association between antipsychotic therapy and hospitalization due to hyponatremia. GreenMedInfo

PMID:  Eur J Intern Med. 2018 Dec 1. Epub 2018 Dec 1. PMID: 30514607 Abstract Title:  Antipsychotics and severe hyponatremia: A Swedish population-based case-control study. Abstract:  BACKGROUND: Antipsychotics have been claimed to cause hyponatremia. The risk associated with individual antipsychotics, or groups (first-generation [FGAs] or second-generation [SGAs] antipsychotics), is not well-documented. The objective of this study was to investigate the association between antipsychotics and hospitalization due to hyponatremia.METHODS: The general Swedish population was the base of this register-based case-control study. Comparisons were made between patients hospitalized with a principal diagnosis of hyponatremia (n=14,359) and matched controls (n=57,383). Multivariable logistic regression adjusting for concomitant drugs, medical conditions, previous hospitalizations and socioeconomic factors was performed to investigate the association between hyponatremia and antipsychotic use. In addition newlyinitiated (90days) or ongoing use was analysed separately.RESULTS: Compared to controls, the adjusted OR (95%CI) for hospitalization due to hyponatremia was for any antipsychotic 1.67(1.5-1.86). Individuals on FGA were more likely to experience severe hyponatremia (2.12[1.83-2.46]) than those on any SGA (1.32[1.15-1.51]). No increased risks, neither as newly initiated nor ongoing therapy, were found for risperidone (0.86[0.56-1.31] and 0.83[0.67-1.02]) and aripiprazole (1.16[0.30-4.46] and 0.62[0.27-1.34]), respectively.CONCLUSIONS: There was an association between antipsychotic therapy and hospitalization due to hyponatremia. The association was stronger for FGAs than SGAs. Risperidone was not associated with an increased risk.

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08:19

Omega-3 fatty acids have beneficial effects on triglyceride metabolism in patients with both schizophrenia and MetS. GreenMedInfo

PMID:  Psychopharmacology (Berl). 2018 Dec 5. Epub 2018 Dec 5. PMID: 30519766 Abstract Title:  Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial. Abstract:  RATIONALE: Individuals with schizophrenia are at increased risk of developing metabolic syndrome (MetS) due to their lifestyle and antipsychotic treatment. Our previous study showed that patients with both schizophrenia and MetS present an increased expression and production of tumor necrosis factor-alpha (TNF-alpha). Omega-3 fatty acids have a documented role in suppressing TNF-alpha; therefore, we hypothesized that they may be of value in relieving inflammation and improving metabolic disturbance in patients with both schizophrenia and MetS.OBJECTIVES: This study employed a randomized placebo-controlled trial to investigate the effects of omega-3 fatty acids on MetS in patients with schizophrenia.METHODS: We recruited 80 patients with both schizophrenia and MetS who received long-term olanzapine monotherapy. The patients were randomly assigned to the OMG-3 group (n=40) or the placebo group (n=40).RESULTS: Patients with both schizophrenia and MetS had significantly higher levels of TNF-alpha than the control subjects (Z=-4.37, P

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07:52

Separate or concurrent use of antiemetics and antipsychotics showed increased risks of Parkinson's disease. GreenMedInfo

PMID:  Int J Clin Pharmacol Ther. 2018 Dec 11. Epub 2018 Dec 11. PMID: 30526811 Abstract Title:  Association between use of antiemetics, antipsychotics, or antidepressants and the risk of Parkinson's disease. Abstract:  OBJECTIVE: Antipsychotics, antidepressants, and antiemetics are well-known causative agents of parkinsonism. However, it is not certain that the use of these medications increases the risk of Parkinson's disease (PD). We aim to define the risk of PD associated with use of antipsychotic, antidepressant, or antiemetic therapy.MATERIALS AND METHODS: We conducted a population-based nested case-control study using data from the South Korean health insurance database. For each PD case, we randomly selected sex, age group, cohort entry date, duration of follow-up, and Charlson comorbidity score-matched controls (up to 3). Exposure was categorized into six groups based on treatments received 1 - 90 days before the index date (separate use of either: antiemetics; antipsychotics; or antidepressants; combined use of antiemetics with either: antipsychotics; or antidepressants; and combined use of all three). We used conditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for PD.RESULTS: Final subjects included 31,428 cases and 94,284 matched controls. We observed an increased risk of PD with the separate use of antiemetics (adjusted OR, 1.08; 95% CI, 1.05 - 1.11) and that of antipsychotics (1.31; 1.12 - 1.52), and the combined use of antiemetics and antipsychotics (1.42; 1.15 - 1.75). Both antidepressants alone and with antipsychotics were not associated with higher risk of PD.CONCLUSIONS: Separate or concurrent use of antiemetics and antipsychotics showed increased risks of PD. Although statistical significance was observed, when taking into account that there still lie unmeasured, unconsidered confounders, there may be no clinical association present. Caution will be needed in prescribing these drugs in patients who have prognostic factors for PD..

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07:21

The use of SSRIs or SNRIs-the most commonly used antidepressant subclass-was associated with an increased risk of type 2 diabetes. GreenMedInfo

PMID:  JAMA Pediatr. 2017 Dec 1 ;171(12):1200-1207. PMID: 29049533 Abstract Title:  Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths. Abstract:  Importance: Antidepressants are one of the most commonly prescribed classes of psychotropic medications among US youths. For adults, there is emerging evidence on the increased risk of type 2 diabetes in association with antidepressant use. However, little is known about the antidepressant treatment-emergent risk of type 2 diabetes among youths.Objective: To assess the association between antidepressant use and the risk of incident type 2 diabetes in youths by antidepressant subclass and according to duration of use, cumulative dose, and average daily dose.Design, Setting, and Participants: A retrospective cohort study was conducted using Medicaid claims data from 4 geographically diverse, large states of youths 5 to 20 years of age who initiated antidepressant treatment from January 1, 2005, to December 31, 2009.Exposures: Antidepressant use (selective serotonin reuptake inhibitors [SSRIs] or serotonin-norepinephrine reuptake inhibitors [SNRIs], tricyclic or other cyclic antidepressants, and other antidepressants) was assessed using the following 4 time-varying measures: current or former use, duration of use, cumulative dose, and average daily dose.Main Outcomes and Measures: Incident type 2 diabetes was assessed using discrete-time failure models, adjusting for disease risk score estimated using more than 125 baseline and time-dependent covariates.Results: In this cohort of 119608 youths aged 5 to 20 years who initiated antidepressant treatment (59087 female youths and 60521 male youths; 54.7% between 5 and 14 years of age) with a mean follow-up of 22.8 months, 79285 [66.3%] had SSRI or SNRI exposure. The risk of type 2 diabetes was significantly greater during current use than former use of SSRIs or SNRIs (absolute risk, 1.29 per 10000 person-months vs 0.64 per 10000 person-months; adjusted relative risk [RR], 1.88; 95% CI, 1.34-2.64) and tricyclic or other cyclic antidepressants (absolute risk, 0.89 per 10000 person-months vs 0.48 per 10000person-months; RR, 2.15; 95% CI, 1.06-4.36), but not of other antidepressants (absolute risk, 1.15 per 10000 person-months vs 1.12 per 10000 person-months; RR, 0.99; 95% CI, 0.66-1.50). Furthermore, for youths currently using SSRIs or SNRIs, the risk of type 2 diabetes increased with the duration of use (RR, 2.66; 95% CI, 1.45-4.88 for>210 days and RR, 2.56; 95% CI, 1.29-5.08 for 151-210 days compared with 1-90 days) and with the cumulative dose (RR, 2.44; 95% CI, 1.35-4.43 for>4500 mg and RR, 2.17; 95% CI, 1.07-4.40 for 3001-4500 mg compared with 1-1500 mg in fluoxetine hydrochloride dose equivalents). By contrast, neither the duratio...

07:06

Psychotic Akathisia by Marci Webber Mad In America

This thing that stirs cant be overcome.
It starts like a steady, aching hum
building to a bumble bees buzz
while a yellowjacket does what it does,

speeding like a train about to derail,
shocking and shaking, you begin to wail,
attacking your entire being,
things seem unlike youre seeing,

feelings of lightning bolts bursting,
muscles tightened, face grimacing, lips pursing,
teeth clenched are desperately biting.
Theres just no use in fighting.

You try to escape it, try to move
Those around you havent a clue
Back and forth, a frenzy ensues
Its torture shakes your mind loose.

Thoughts strike like youre a lightning rod,
delusions are saturated with God.
Death becomes something you cant avoid.
Youre now more than just paranoid.

A snap, a shot, or slash,
As reality, an akathisia clash.

*****

Back to Poetry

06:59

Vaccine vs. Disease Trade-offs: Cheating childrens immune systems Health Nut News

By the Childrens Health Defense Team These days, one policy-maker after another seems to be promoting no-exceptions vaccination policieshawking an incessant and growing barrage of childhood vaccines that begins prenatally and continues throughout childhood. Despite these efforts, the narrative that vaccines are keeping children healthy is rapidly crumbling. Rates of chronic and autoimmune illness in []

The post Vaccine vs. Disease Trade-offs: Cheating childrens immune systems appeared first on Health Nut News.

06:59

These findings suggest that antipsychotic use is associated with increased risk of unexpected death among children and youths. GreenMedInfo

PMID:  JAMA Psychiatry. 2018 Dec 12. Epub 2018 Dec 12. PMID: 30540347 Abstract Title:  Association of Antipsychotic Treatment With Risk of Unexpected Death Among Children and Youths. Abstract:  Importance: Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown.Objective: To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications.Design, Setting, and Participants: This retrospective cohort study was conducted from 1999 through 2014 and included Medicaid enrollees aged 5 to 24 years in Tennessee who had no diagnosis of severe somatic illness, schizophrenia or related psychoses, or Tourette syndrome or chronic tic disorder. Data analysis was performed from January 1, 2017, to August 15, 2018.Exposures: Current, new antipsychotic medication use at doses higher than 50 mg (higher-dose group) or 50 mg or lower chlorpromazine equivalents (lower-dose group) as well as control medications (ie, attention-deficit/hyperactivity disorder medications, antidepressants, or mood stabilizers) (control group).Main Outcomes and Measures: Deaths during study follow-up while out of hospital or within 7 days after hospital admission, classified as either deaths due to injury or suicide or unexpected deaths. Secondary outcomes were unexpected deaths not due to overdose and death due to cardiovascular or metabolic causes.Results: This study included 189361 children and youths in the control group (mean [SD] age, 12.0 [5.1] years; 43.4% female), 28377 in the lower-dose group (mean [SD] age, 11.7 [4.4] years; 32.3% female), and 30120 in the higher-dose group (mean [SD] age, 14.5 [4.8] years; 39.2% female). The unadjusted incidence of deathin the higher-dose group was 146.2 per 100000 person-years (40 deaths per 27354 person-years), which was significantly greater than that in the control group (54.5 per 100000 population; 67 deaths per 123005 person-years) (P

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06:46

CDCs Own Data Support Link Between MMR Vaccine and Autism Vaccine Impact

brian-hooker-1024x570

Re-analysis of CDC Data on MMR Vaccine and Autism

by Focus for Health

After four long years, Dr. Brian Hookers reanalysis of the CDCs MMR-autism data from the original Destefano et al. 2004 Pediatrics paper has been republished in the Winter 2018 Edition of the Journal of American Physicians and Surgeons.

The data, when properly analyzed, using the CDCs own study protocol, show a strong, statistically significant relationship between the timing of the first MMR vaccine and autism, specifically in African American males. In addition, a relationship also exists in the timing of the MMR vaccine and those individuals who were diagnosed with autism without mental retardation.

These relationships call into question the conclusion of the original Destefano et al. 2004 paper which dismissed a connection between the MMR vaccine and autism.

Read the reanalysis paper

Press Release

Association of American Physicians and Surgeons 1601 N. Tucson Blvd. Suite 9
Tucson, AZ 85716
(800) 635-1196
www.aapsonline.org

Dec 7, 2018

Contact: Brian Hooker, Ph.D., drbrianhooker@gmail.com, or Jane M. Orient, M.D., (520) 323-3110, janeorientmd@gmail.com

Re-analysis of CDC Data Suggests Need for Further Investigation on MMR Vaccine and Autism, according to Article in the Journal of American Physicians and Surgeons

Tucson, Ariz. As early as 2001, the Centers for Disease Control and Prevention (CDC) had data showing an increased rate of autism diagnoses in black male schoolchildren in Atlanta who received their first measles-mumps-rubella (MMR) vaccination before 36 months of age, compared with those who received it later, writes Brian Hooker, Ph.D., in the winter issue of the Journal of American Physicians and Surgeons. The relationship loses its statistical significance if the analysis is restricted to children with a Georgia birth certificate, which decreases the sample size by about 40 percent.

Dr. Hooker reanalyzed the same data set, using the same methodology of conditional logistic regression. Children lacki...

06:20

Fresh cabbage consumption in volunteers showed a higher antioxidant capacity than after fermented cabbage intake. GreenMedInfo

PMID:  Food Chem. 2016 Jan 1 ;190:730-740. Epub 2015 Jun 9. PMID: 26213032 Abstract Title:  The impact of red cabbage fermentation on bioavailability of anthocyanins and antioxidant capacity of human plasma. Abstract:  The effect of red cabbage fermentation on anthocyanin bioavailability and plasma antioxidant capacity in humans was studied. In a randomized crossover study, 13 volunteers consumed fresh and fermented red cabbage. Blood and urine samples were collected before and after consumption. Analyses of anthocyanins by HPLC-MS/MS and plasma antioxidant capacity by photochemiluminescence assay were conducted. Red cabbage products contained 20 different nonacylated and acylated anthocyanins with the main structure of cyanidin triglucosides. The anthocyanins ingested were present in physiological fluids in form of 18 native anthocyanins and 12 metabolites (methylated, glucuronided, sulfated). Among cyanidin metabolites identified, methylated forms were predominant. Bioavailability of anthocyanin from fresh red cabbage was over 10% higher than from fermented red cabbage. Upon fresh cabbage consumption, volunteers plasma showed higher antioxidant capacity than after fermented cabbage intake. The study has shown that fermentation process affects red cabbage anthocyanins bioavailability and human plasma antioxidant capacity.

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04:45

Inhibitory potential of red cabbage against digestive enzymes linked to obesity and type 2 diabetes. GreenMedInfo

PMID:  J Agric Food Chem. 2017 Aug 23 ;65(33):7192-7199. Epub 2017 Aug 9. PMID: 28753316 Abstract Title:  Inhibitory Potential of Red Cabbage against Digestive Enzymes Linked to Obesity and Type 2 Diabetes. Abstract:  Assays of the inhibitory potential against enzymes involved in carbohydrate and lipid digestion (-amylase, -glucosidase, and lipase) as well as the total contents of phenolics and anthocyanins, anthocyanin profile, and antioxidant capacity revealed significant differences (p

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04:36

ABC: Dad turns in his own daughter to face animal cruelty charges Health Nut News

(Photo Credit: The Washington County Humane Society) Pay attention parents: even if its hard, its always best to do whats right. After recognizing a photo that was circulating on social media of a starving, skinny dog, William Wright was pretty sure he knew the sweet pup; it was his daughter, Tonysha Wrights pet. And now, after []

The post ABC: Dad turns in his own daughter to face animal cruelty charges appeared first on Health Nut News.

04:25

Anthocyanin-rich extract from red chinese cabbage alleviates vascular inflammation. GreenMedInfo

PMID:  Int J Mol Sci. 2018 Mar 12 ;19(3). Epub 2018 Mar 12. PMID: 29534512 Abstract Title:  Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular Inflammation in Endothelial Cells and Apo EMice. Abstract:  Anthocyanins, the most prevalent flavonoids in red/purple fruits and vegetables, are known to improve immune responses and reduce chronic disease risks. In this study, the anti-inflammatory activities of an anthocyanin-rich extract from red Chinese cabbage (ArCC) were shown based on its inhibitory effects in cultured endothelial cells and hyperlipidemic apolipoprotein-deficient mice. ArCC treatment suppressed monocyte adhesion to tumor necrosis factor--stimulated endothelial cells. This was validated by ArCC's ability to downregulate the expression and transcription of endothelial adhesion molecules, determined by immunoblot and luciferase promoter assays, respectively. The regulation of adhesion molecules was accompanied by transcriptional inhibition of nuclear factor-B, which restricted cytoplasmic localization as shown by immunocytochemistry. Administration of ArCC (150 or 300 mg/kg/day) inhibited aortic inflammation in hyperlipidemic apolipoprotein E-deficient mice, as shown by in vivo imaging. Immunohistochemistry and plasma analysis showed that the aortas from these mice exhibited markedly lower leukocyte infiltration, reduced plaque formation, and lower concentrations of blood inflammatory cytokines than those observed in the control mice. The results suggest that the consumption of anthocyanin-rich red Chinese cabbage is closely correlated with lowering the risk of vascular inflammatory diseases.

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04:25

Study: Home Cleaning Products Exposure Equivalent to Smoking 20 Cigarettes a Day REALfarmacy.com

Source: Study: Home Cleaning Products Exposure Equivalent to Smoking 20 Cigarettes a Day For more content like this visit REALfarmacy.com.

By Leah Zerbe, MS, NASM-CPT, NASM-CES Like many Americans, I grew up in the age of oversanitation in a house full of home cleaning products. My mom regularly scrubbed down our kitchen counter with household bleach. The sink was so shiny that it sparkled, and our floors were spotless. She didnt do this to hurt us; she thought []

Source: Study: Home Cleaning Products Exposure Equivalent to Smoking 20 Cigarettes a Day Learn more at REALfarmacy.com - Healthy News and Information.

04:16

CDC Whistleblower Case to Resurface in 2019? Natural Blaze

By Jon Rappoport

Representative-elect Mark Green (R) (Tennessee) (twitter) pledges to investigate claims that the CDC is fraudulently managing the vaccine-damage data they collect. This story is a developing.

In light of this development, I am re-posting this article of mine from July 2015. July 2015 was seemingly the last time a Congressman took a stance on this issue and did so on the House floor in order to get claims of fraud into the Congressional record.

Lets take a walk down memory lane


Bombshell: CDC destroyed vaccine documents

July 2015

the [CDC] co-authors scheduled a meeting to destroy documents related to the [MMR vaccine] study. The remaining four co-authors all met and brought a big garbage can into the meeting room and reviewed and went through all the hard copy documents that we had thought we should discard and put them...

04:14

CNN: Delta Air Lines bans young puppies and kittens as support animals Health Nut News

Over the last year, the topic of support animals has been hotly debated. And this summer a number of airlines made changes in their policies. But now, Delta is making yet another change. (Im wondering, is it possible we will see either extremely tight support animals rules or no animals allowed at all, very soon?) RELATED []

The post CNN: Delta Air Lines bans young puppies and kittens as support animals appeared first on Health Nut News.

04:00

What Do Crowd Control, Burning Skin, Your Street Corner, and Superbugs Have in Common? The Alliance for Natural Health

The short answer: 5G networks, which are coming to your town. Action Alert!

Recently we told you how telecom companies are working with the federal government to eliminate local control over the deployment of 5G networks, which are billed as the next best thing in wireless technology. Recent research pointing to the health implications of 5G technology reinforces the need to have local control over how its used, but more importantly asks the question of whether we should hit the pause button altogether.

5G technology will make wireless networks capable of more data streaming at faster speeds because it uses a broader frequency spectrum, as explained here. Whereas current 4G networks use up to 6 GHz, 5G will use frequencies between 24 GHz and 100 GHz, known as millimeter-wave frequencies. This means that the dozens of small cell towers that will be installed in your neighborhood will be emanating millimeter waves.

If that doesnt sound scary, consider this. The Department of Defense has developed a non-lethal crowd control device called the Active Denial System (ADS). The ADS works by firing a high-powered beam of 95 GHz waves at a targetthat is, millimeter wavelengths.  Anyone caught in the beam will feel like their skin is burning. The burning sensation stops once the target leaves the beam.

So, what were talking about with 5G technology is being exposed to the same kind of waves day in and day out, only at a lower power than the ADS. Have safety studies confirmed that such exposure is safe? No. As we saw in our previous article on this topic, the government seems more interested in helping the telecom industry railroad local communities who want to have a say over how or whether this tech gets installed.

Theres more. Research from a team of Israeli physicists has found that there are new problems to consider with exposure to millimeter waves. When the wavelength of the energy approaches the dimensions of our biological structures, i.e. our skin and sweat ducts, previous assumptions about the safety of energy radiation are no longer valid. The research shows that, with millimet...

03:57

They Listened: Organics and CBD Get Boost in Farm Bill The Alliance for Natural Health

Plus, poison provisions removed from final bill. Action Alert!

The last few weeks of 2018 have seen some rapid developments for the Farm Bill, the huge piece of legislation that gets passed every four years and allocates almost a billion dollars over ten years. For natural health advocates, there are some good provisions in the bill, including the legalization of industrial hempwhich is an important step toward ensuring access to CBD oiland measures aimed at stemming the tide of fake organics into the US.

These provisions were part of the Farm Bill that passed the Senate a few months ago, after the House passed its version. Now a compromise bill has been created and rapidly approved by both the Senate and the House.

The final Farm Bill legalizes hemp as an agricultural commodity and removes it from the federal list of controlled substances. It also defines cannabinoids (CBD) with a THC concentration of less than 0.3% as hemp, thus legalizing CBD oil that meets the 0.3% threshold. This is an important step in our campaign to fight for consumer access to CBD oil, a cheap, safe, effective, and non-addictive alternative to opioids for pain.

Remember, though, that this would only remove one of the two major threats to consumer access to CBD oil. Recall that a pharmaceutical company, GW Pharmaceuticals, has developed a CBD-based drug for a rare form of childhood epilepsywhich just received FDA approval. The FDA has said that CBD is not a supplement because GW filed an investigational new drug (IND) application on CBD before it was sold as a supplementan agency position that we are fighting. Nonetheless, its encouraging that the government is proposing to remove one of the major hurdles to affordable CBD oil.

The final Farm Bill also includes provisions aimed at increasing oversight over the organic supply chain in an e...

03:55

Banned for Use in War, But OK for Our Crops The Alliance for Natural Health

Apparently the Geneva Convention doesnt protect against use in domestic agriculture. Action Alert!

Researchers who recently examined studies sponsored by Dow Chemical and used by the EPA to approve chlorpyrifos, a type of insecticide, found inaccuracies in what the company reported to the agency. Worse, there is also evidence that EPA scientists pointed out these failings to agency officials, but were ignored. It is another example of industry using the power of the federal government to put profits before public health.

The researchers found that the lab used a two percent cut off to determine what was statistically significant through most of the study, instead of the customary 5 percentmeaning it would be more likely that exposure to chlorpyrifos would appear safe. The rat studies submitted to the EPA also did not model human exposure and potential brain impacts, among other failures.

To make matters worse, it appears that agency officials were warned by EPA toxicologists of the studys problems. A memo sent to EPA management said that The study was graded unacceptable due to an inadequate presentation of the statistical data analysis.

Keep in mind, too, that the EPA is aware of evidence that found exposure to chlorpyrifos caused measurable differences in childrens brain function, on average dropping their IQs a few points. Some research has linked the pesticides to autism and other brain disorders. Theres also evidence to suggest that some children are more vulnerable to the chemicals than others due to their genetic makeup. These health effects should come as no surprise when we consider that chlorpyrifos were developed as a nerve gas during World War II by the Nazis, though they werent used in battle. Chemical weapons were prohibited by the Geneva Convention after WWIso the chemical is too inhumane to use in war, but A-OK for our food, according to the governments thinking.

The EPA is currently in the midst of a legal battleto keep chlorpyrifos on the market. In August, the Ninth Circuit Court of Appeals ordered the EPA to ban the chemical; the EPA has appealed the decision. It looks like the EPA will fight tooth and nail for youif youre one of the largest chemical companies in the world.

This is part of a much larger problem. To evaluate pesticides, herbicides, and insecticides, the EPA ...

02:54

Why are so many people unexpectedly dying so young in this nation? Health Nut News

Two years ago, U.S. Centers for Disease Control (CDC) data revealed a sudden drop in life expectancy in the U.S. for 2015. It was the first decline in 20 years. The trend continued in 2016, and the latest data for 2017 show the downward trend continuing for the third year in a row, which makes []

The post Why are so many people unexpectedly dying so young in this nation? appeared first on Health Nut News.

02:41

ICU Stethoscopes Loaded With Disgusting Bacteria Vaxxter

According to a new report, stethoscopes are bacteria-infested. Worse more, it seems cleaning them doesnt help the issue. Many of the bacterium discovered on the stethoscopes was linked to typical infections, such as Staphylococcus. Researchers...

The post ICU Stethoscopes Loaded With Disgusting Bacteria appeared first on Vaxxter.

02:32

The results suggest that red cabbage potentiates pentobarbital hypnosis without any toxic effect. GreenMedInfo

PMID:  J Pharm Bioallied Sci. 2018 Jan-Mar;10(1):48-53. PMID: 29657508 Abstract Title:  Hypnotic Effect of Red Cabbage () on Pentobarbital-Induced Sleep in Mice. Abstract:  Objective: The present study was performed to investigate the effect of hydroalcoholic extract of red cabbage and its fractions on sleeping behavior in mice.Materials and Methods: The extract and its fractions were injected to mice and sleep duration as well as sleep latency were recorded. Furthermore, toxicity of the extract was determined bothand.Results: The extract increased sleep duration at doses of 50-200mg/kg (

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02:00

Can We Unlearn The Fear That Creates Our Reality? Natural Blaze

By Josh Richardson

Imagination is a wonderful thing. Emotions are often a result of the mind telling us stories without our direction over the outcome. When we imagine any fear repeatedly in a safe environment, soon our phobia, and our brains response to it, begins to subside.

Thats the takeaway of a new brain imaging study led by CU Boulder and Icahn School of Medicine researchers, suggesting that imagination can be a powerful tool in helping people with fear and anxiety-related disorders overcome them.

This research confirms that imagination is a neurological reality that can impact our brains and bodies in ways that matter for our wellbeing, said Tor Wager, director of the Cognitive and Affective Neuroscience Laboratory at CU Boulder and co-senior author of the paper, published in the journal Neuron.

Being afraid of the unknown is not a new concept. From birth to death weve been trained to fear everything for a very long time. The dangers of modern life have a stranglehold on peoples imaginations. Sociologists call the phenomenon a risk society, describing cultures increasingly preoccupied with threats to safety, both real and perceived, but most definitely imagined.

Our ability to judge risk is sophisticated, and instinctual decisions often serve us well. But when something doesnt quite seem to sync up, gut to head, then its time to pause and at least question whats causing the discrepancy.

...

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23:57

Singulair and Montelukast asthma medication, linked to psychotic episodes in children, to be sold with warnings Health Nut News

The popular asthma drug known as Montelukast or Singulair, which has been linked to cases of suicidal thoughts and depression in children, will now be sold with side effect warnings inside its packaging. (It is normally prescribed for children aged two to 14 with frequent intermittent, mild persistent or exercise-induced asthma.) RELATED STORY: This sweet treat []

The post Singulair and Montelukast asthma medication, linked to psychotic episodes in children, to be sold with warnings appeared first on Health Nut News.

22:02

Human papillomavirus immunisation of adolescent girls: improving coverage through multisectoral collaboration in Malaysia AGE OF AUTISM

HPV Vaccine On TrialNote: "Universal vaccination" as a goal? Let's hope the authors read The HPV Vaccine On Trial.


BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4602 (Published 07 December 2018) Cite this as: BMJ 2018;363:k4602

https://www.bmj.com/content/363/bmj.k4602

Saidatul Buang and colleagues report on collaborative efforts to introduce HPV vaccination in Malaysia and increase coverage

Human papillomavirus immunisation of adolescent girls: improving coverage through multisectoral collaboration in Malaysia

Cervical cancer is the fourth most common cancer in women globally.1 Human papillomavirus (HPV) types 16 and 18 collectively cause 70% of cervical cancers and precancerous cervical lesions.1 The UN joint global programme on cervical cancer prevention and control includes HPV immunisation for girls as one of its three priorities at country level, together with screening and treatment for cervical pre-cancer, and diagnosis and treatment of invasive cervical cancer.2 In Malaysia, the age standardised cervical cancer rate is 7.8 per 100000 females, making it the third most common cancer in women, with 4352 new cases reported for 2007-11.3 Malaysias HPV immunisation programme was introduced in 2010, within a healthcare system that has a credible track record (box 1,...

22:01

Why Is Karl Taylor Dead? Mad In America

From The Marshall Project: The statement noted that Taylor had resided on a cellblock for inmates with behavioral issues. But that was the only official nod to the underlying circumstances of his deaththat this fatal collision between the keepers and the kept involved one of the many people with a tortured mind who wash up on the shores of Americas prisons, institutions supremely ill-equipped to handle them. Nor did any authority state the obvious: that absent the presence of a deadly weaponin this case, a long wooden stickand but for a guards stubborn insistence that even a mentally ill inmate must clean his cell, this was an avoidable tragedy.

Jails and prisons are among the least therapeutic environments in the world, says Alisa Roth, who toured facilities across the country for her recent book, Insane: Americas Criminal Treatment of Mental Illness. Youre not bringing out the best in their behavior; youre bringing out the worst in their behavior, Roth told me.

At the time of his death, Taylor was one of nearly 10,000 people in New Yorks state correctional facilities diagnosed with a mental illnessone out of every five prisoners. Roughly half are, like Taylor, considered seriously mentally ill, suffering from schizophrenia or another psychotic disorder. They are men and women who have trouble coping with daily living needs, often unable to follow orders in a setting where a military-style strictness governs every movement. In New York, the number of inmates with mental-health issues has risen even as the overall number of people held in the states prisons has fallen, from a high of 72,000 in 1999 to some 48,000 currently held in the states 54 correctional facilities. And New York is not alone. It is almost everywhere, Roth says. Even as the number of prisoners goes down, the number of people incarcerated with mental illness goes up. []

Ramsay-Nobles said shes glad the lawsuit has provided some answers about her brothers death, as troubling as those answers are. Its made me wonder, what about the others like him in prison? she told me recently. The ones we dont hear about?'

Article 

22:00

Congressman-Elect Mark Green Risks the Green by Questioning Vaccine Safety AGE OF AUTISM

TennesseeNote: For decades, politicians who have seen first hand the trauma of vaccine induced autism have abandoned us. Remember Representative Elijah Cummings at the hearings so many year ago - appalled, angry and then... apathetic? Once pharma turns the screws, most politicians fold like cheap lawn chairs.  As you read the article, you may, like me, be at odds with his stances on other topics. Big time.

###

A soon-to-be congressman from Tennessee told constituents Tuesday he believed vaccines may be causing autism, questioning data from the Centers for Disease Control and other institutions disproving such a theory.

Not only did Republican Mark Green, a Congressman-elect from Clarksville who is also a medical doctor, express hesitation about the CDC's stance on vaccines, he also said he believed the federal health agency has "fraudulently managed" the data.

His remarks came in response to an audience question at a town hall meeting in Franklin from a woman identifying herself as the parent of a young adult with autism. The woman was concerned about possible cuts to Medicaid funding.

"Let me say this about autism," Green said. "I have committed to people in my community, up in Montgomery County, to stand on the CDCs desk and get the real data on vaccines. Because there is some concern that the rise in autism is the result of the preservatives that are in our vaccines

"As a physician, I can make that argument and I can look at it academically and make the argument against the CDC, if they really want to engage me on it," Green said.

Despite calls by the anti-vaccination movement for parents not to vaccinate their children against a number of diseases, CDC data disproves the movement's findings.

Through multiple studies, the CDC has found no link between autism and vaccines, including from the mercury-based preservative in vaccines referenced by Green.

The American Academy of Pediatrics has reiterated those findings.

"Claims that vaccines are linked to autism, or are unsafe when...

21:00

Anversa cardiac stem cell lab earns 13 retractions Retraction Watch

Two months after Harvard and the Brigham and Womens Hospital said they were requesting the retraction of more than 30 papers from a former cardiac stem cell lab there, two American Heart Association journals have retracted more than a dozen papers from the lab. Yesterday, Circulation retracted three papers, and Circulation Research retracted 10. All 13 were Continue reading Anversa cardiac stem cell lab earns 13 retractions

18:04

Consumption of red cabbage should be a natural therapy to treat NASH in diabetic patients. GreenMedInfo

PMID:  Oxid Med Cell Longev. 2018 ;2018:7019573. Epub 2018 Sep 30. PMID: 30363947 Abstract Title:  Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats. Abstract:  Aims: Oxidative stress (OS) plays a major role in type 2 diabetes and its vascular and hepatic complications, and novel therapeutic approaches include natural antioxidants. Our previous chemical and biological studies demonstrated the antioxidant activities of red cabbage (RC), and here, we aimed to determine theeffects of 2-month long RC consumption using a high-fat/high-fructose model of diabetic rats.Results: This vegetable, associated with lifestyle measurement, was shown to decrease OS and increase vascular endothelial NO synthase expression, ensuring vascular homeostasis. In the liver, RC consumption decreased OS by inhibiting p22phox expression and Nrf2 degradation and increasing catalase activity. It inhibited the activation of SREBP (1c, 2), ChREBP, NF-B, ERK1/2, PPAR, and GS and SIRT1 decrease, as observed in diabetic rats.Conclusion/innovation: RC consumption led to metabolic profile improvement, together with hepatic function improvements. Although lifestyle changes are not sufficient to prevent diabetic complications, enrichment with RC avoids progression hepatic complications. This antioxidant strategy using RC does not only able to increase antioxidant defense, such as classical antioxidant, but also able to assure a metabolic and energetic balance to reverse complications. Whereas traditional medical therapy failed to reverse NASH in diabetic patients, consumption of RC should be a natural therapy to treat it.

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17:00

Duration of Sleep Can Increase Risk of Falling Articles

Falls may not grab headlines like more sensational causes of injury, but they rank as the second leading cause of accidental or unintentional injury and death worldwide. Every year, more than 37 million falls occur that are severe enough to require medical attention, and 646,000 people die as a result, most of them aged 65 years and older.1

Its estimated that 1 in 3 older adults falls each year, and the risk increases with age. Failing vision and hearing can contribute to fall risk, as can changes in cognition that may occur with age. Other health conditions like diabetes, foot problems, low blood pressure, muscle weakness and even heart disease may also affect your balance and increase your risk of falling.2

Another important risk factor one thats often overlooked is sleep, or lack thereof. A simple way to lower your risk of falls and related fractures is to ensure youre getting a good nights sleep something thats elusive to one-third of Americans.3

How Long You Sleep Influences Your Risk of Falls and Fractures

Researchers from the University of Pittsburgh in Pennsylvania used data from more than 157,000 women to investigate the association between sleep and falls.4 Interestingly, there appears to be a sweet spot when it comes to sleep, as both sleeping too much or too little may influence your risk.

The study revealed that, compared to women who slept the recommended seven to eight hours a night, those who slept for less than five hours or more than 10 were about 25 percent more likely to suffer from recurrent falls, defined as falling at least two times in a one-year period.

Along with sleep duration, poor sleep quality, insomnia and other sleep disturbances were also associated with an increased risk of recurrent falls. For short sleepers (less than five hours a night), the risk of fractures, including those in the upper limb, lower limb and central body, was increased.

In conclusion, short and long sleep duration and poor sleep quality were independently associated with increased odds of recurrent falls. Short sleep was associated with [a] modest increase in fractures, the researchers said.5 Lead study author Jane Cauley of the University of Pittsburgh said in a news release:6

Falls are an important public health problem among older adults and lead to moderate to severe injuries. Most...

Star Anise: Add This Special Spice to Your Meals Articles

Spices come in all shapes and sizes, and star anise (Illicium verum Hook.f.)1 is a classic example. Its dark and attractive color and unique star shape makes it stand out from other spices. There's also research highlighting potential health benefits star anise can offer, making it a spice you should consider adding to your cooking arsenal.

What Is Star Anise?

Star anise grows as dark brown pods with six to eight segments each containing a seed. This spice hails from an evergreen tree plant native to southwest China2 and northeast Vietnam, although it's also cultivated in Spain, France, Italy, Morocco, India and the Philippines.3 Star anise tastes sweet and spicy, but slightly more bitter than Spanish anise. Some chefs use it to provide a licorice flavor for savory dishes.4

Some people think that star anise and anise seed are the same. While both spices contain a substance called anethole,5 their similarities end there. Anise seed belongs to the Apiaceae family,6 while star anise comes from the Illiciaceae family.7 Anise seed is used more in Western dishes, particularly in Greek and French cuisines,8 while star anise is more common in Asian cooking.9

6 Health Benefits of Star Anise

If you're looking for a flavorful spice with health benefits, star anise might be a good choice. Research has revealed that star anise may:

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Opioid Addiction and Suicides Have Caused Decline in US Life Expectancy Articles

Two years ago, U.S. Centers for Disease Control (CDC) data revealed a sudden drop in life expectancy in the U.S. for 2015.1,2 It was the first decline in 20 years. The trend continued in 2016,3 and the latest data for 20174 show the downward trend continuing for the third year in a row, which makes it the longest downward trend since World War I and the 1918 flu pandemic.5

Overall, the average life expectancy for the total U.S. population in 2017 was 78.6 years, down one-tenth of a percentage point from 2016. Life expectancy for men also declined, from 76.2 years in 2016 to 76.1 years in 2017, while life expectancy for women remained stable at 81.1 years.

In all, life expectancy for Americans has fallen by about four months over the past three years. Robert Anderson, chief of mortality statistics at the CDC, commented on the latest report:

"The idea that a developed wealthy nation like ours has declining life expectancy just doesn't seem right. If you look at the other wealthy countries of the world, they're not seeing the same thing."6

Christopher Murray, the director of the Institute for Health Metrics and Evaluation at the University of Washington, also commented, saying the data "confirms that there's a profound change in the trajectory of mortality. This should really be getting everyone's attention in a major way."7

Drug Overdoses Drive Declining Life Expectancy in US

The initial decline in 2015 was primarily attributed to a rise in several categories of preventable deaths,8 including opioid overdoses, highlighting the failure of the American health care system to properly address the root causes of chronic disease and rein in the burgeoning opioid addiction epidemic.

The decline in 2016 was again driven largely by an increased number of deaths among younger Americans, fueled by opioid and fentanyl overdoses, while the 2017 drop is being attributed to a combination...

16:14

CBS: Whole foods ranked worst on cancer-linked package chemicals, says it will remove them Health Nut News

More bad news from Whole Foods RELATED STORY: BETRAYED: Whole Foods suspends GMO labeling promise, will continue selling unlabeled GMOs after five-year LIE to its own customers Although Whole Foods Market is routinely hailed for their high standards on food, theyve been ranked worst in a study of five major U.S. grocery chains for chemicals it []

The post CBS: Whole foods ranked worst on cancer-linked package chemicals, says it will remove them appeared first on Health Nut News.

16:12

Video: Media Betrays Homosexuals to Protect Islam Front Page - The Health Wyze Report

In an effort to shield Islam from all criticism, liberals and those in the media have been ignoring instances of Islam-motivated attacks on homosexuals. These attacks are increasing in areas where there is mass immigration from the Middle East.

You may watch this on YouTube if there are any problems watching the video at this site.

16:10

Increased consumption of sugar-sweetened beverages was closely linked with a higher prevalence of obesity and MetS in the Korean population. GreenMedInfo

PMID:  Nutrients. 2018 Oct 9 ;10(10). Epub 2018 Oct 9. PMID: 30304842 Abstract Title:  Sugar-Sweetened Beverage Consumption in Relation to Obesity and Metabolic Syndrome among Korean Adults: A Cross-Sectional Study from the 20122016 Korean National Health and Nutrition Examination Survey (KNHANES). Abstract:  It is well known that the consumption of sugar-sweetened beverages (SSBs) increases the risk of developing obesity and metabolic syndrome (MetS). However, there are not many studies investigating the link between SSBs and increased incidences of diseases in the Asian population, and in particular, in Korea. We explored the association of SSB consumption with the risk of developing obesity and MetS among Korean adults (12,112 participants from the 20122016 Korean National Health and Nutrition Examination Survey). We calculated the total SSB consumption frequency by counting each beverage item, including soda beverages, fruit juices, and sweetened rice drinks. Obesity was defined as a body mass index 25 kg/m, and MetS was defined using theNational Cholesterol Education Program, Adult Treatment Panel III. A survey logistic regression analyses was conducted to examine the association of SSB consumption with obesity and MetS, adjusting for related confounders such as age, energy intake, household income, education, alcohol drinking, smoking status, and physical activity. The SSB consumption was positively associated with an increased risk of the prevalence for obesity (Odd ratio (OR): 1.60; 95% confidence interval (CI): 1.232.09;for trend = 0.0009) and MetS (OR: 1.61; 95% CI: 1.202.16;for trend = 0.0003) among women. In men, SSB consumption only contributed to a higher prevalence of obesity (OR: 1.38; 95% CI: 1.111.72;for trend = 0.0041). In conclusion, increased consumption of SSBs was closely linked with a higher prevalence of obesity and MetS in the Korean population.

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16:00

Diets high in sugar-sweetened beverages but low in fruits and vegetables contribute to adiposity and a pro-inflammatory adipokine profile. GreenMedInfo

PMID:  Br J Nutr. 2018 Dec ;120(11):1230-1239. Epub 2018 Oct 30. PMID: 30375290 Abstract Title:  A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile. Abstract:  Diet, obesity and adipokines play important roles in diabetes and CVD; yet, limited studies have assessed the relationship between diet and multiple adipokines. This cross-sectional study assessed associations between diet, adiposity and adipokines in Mexican Americans. The cohort included 1128 participants (age 34782 years, BMI 29559 kg/m2, 732 % female). Dietary intake was assessed by 12-month food frequency questionnaire. Adiposity was measured by BMI, total percentage body fat and percentage trunk fat using dual-energy X-ray absorptiometry. Adiponectin, apelin, C-reactive protein (CRP), dipeptidyl peptidase-4 (DPP-IV), IL-1, IL-1ra, IL-6, IL-18, leptin, lipocalin, monocyte chemo-attractant protein-1 (MCP-1), resistin, secreted frizzled protein 4 (SFRP-4), SFRP-5, TNF- and visfatin were assayed with multiplex kits or ELISA. Joint multivariate associations between diet, adiposity andadipokines were analysed using canonical correlations adjusted for age, sex, energy intake and kinship. The median (interquartile range) energy intake was 9514 (7314, 11912) kJ/d. Overall, 55 % of total intake was accounted for by carbohydrates (24 % from sugar). A total of 66 % of the shared variation between diet and adiposity, and 34 % of diet and adipokines were explained by the top canonical correlation. The diet component was most represented by sugar-sweetened beverages (SSB), fruit and vegetables. Participants consuming a diet high in SSB and low in fruits and vegetables had higher adiposity, CRP, leptin, and MCP-1, but lower SFRP-5 than participants with high fruit and vegetable and low SSB intake. In Mexican Americans, diets high in SSB but low in fruits and vegetables contribute to adiposity and a pro-inflammatory adipokine profile.

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15:55

Sugar-sweetened beverages intake is associated with blood pressure and sympathetic nervous system activation in children. GreenMedInfo

PMID:  Clin Nutr ESPEN. 2018 Dec ;28:232-235. Epub 2018 Sep 11. PMID: 30390887 Abstract Title:  Sugar-sweetened beverages intake is associated with blood pressure and sympathetic nervous system activation in children. Abstract:  INTRODUCTION: Research in adults shows high intakes of sugar-sweetened beverages (SSBs) increases blood pressure (BP), however evidence in children is scarce and inconclusive. No studies have investigated autonomic nervous system (ANS) activation due to SSBs in children. Our aim was to investigate the associations between SSBs intake, BP and ANS activation in children.METHODS: Cross-sectional data collected in 2008-2010 at age 5/6 (n = 2519) and in 2015-2016 at age 11/12 (n = 769) years in the Amsterdam Born Children and their Development-study were analyzed in 2017. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as pre-ejection period (PEP; sympathetic activation) and respiratorysinus arrhythmia (RSA; parasympathetic activation) were measured during supine position. SSBs intake was self-reported.RESULTS: After adjustments for covariates, including weight status, no associations between SSBs intake, BP and ANS measures were found at age 5/6. At age 11/12, one serving/day increase in SSBs was associated with 0.8 mmHg increase in SBP (95%CI:0.4; 1.2), 0.3 mmHg increase in DBP (0.0; 0.5) and 0.9 msec decrease in PEP (-1.5;-0.2). Children in the highest SSBs tertile had an increase of 2.3 mmHg in SBP (0.7; 4.0) and a decrease of 3.6 msec in PEP (-6.7;-0.6) compared to children in the lowest tertile.CONCLUSION: In children aged 11/12, high intake of SSBs was associated with increased BP, which might be due to increased sympathetic nervous system activation. Importantly, these associations were independent of weight status.

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15:49

This meta-analysis indicates that sugar-sweetened beverages consumption might be associated with a modestly higher risk of depression. GreenMedInfo

PMID:  J Affect Disord. 2018 Nov 6 ;245:348-355. Epub 2018 Nov 6. PMID: 30419536 Abstract Title:  Sugar-sweetened beverages consumption and the risk of depression: A meta-analysis of observational studies. Abstract:  BACKGROUND: It remains inconsistent whether sugar-sweetened beverages (SSBs) consumption increases the risk of depression. Thus, we carried out a meta-analysis to evaluate the association between SSBs consumption and the risk of depression.METHODS: PubMed and Web of Science were searched for relevant articles published up to June 2018. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated by the fixed-effects model or random effect model based on heterogeneity test.RESULTS: 10 observational studies involving 37,131 depression cases among 365,289 participants were included. The combined risk of depression for the highest versus lowest consumption of SSBs was 1.31 (95% CI 1.24-1.39). The findings were consistent in the cross-sectional studies (RR=1.38; 95% CI 1.26-1.52) as well as in the cohort studies (RR=1.30; 95% CI 1.19-1.41) A nonlinear dose-response relationship was found (P=0.0103) for depression risk and SSBs consumption. Compared with SSBs nondrinkers, those who drank the equivalent of 2 cups/day of cola might increase the risk of depression by 5% (RR=1.05; 95% CI 1.01-1.09). And the equivalent of 3cans/day of cola might have approximately 25% higher risk of depression.LIMITATIONS: 10 studies were included in this meta-analysis, of which only 4 were cohort studies, and more cohort studies need to be performed in the future.CONCLUSIONS: This meta-analysis indicates that SSBs consumption might be associated with a modestly higher risk of depression. The results need to be further confirmed in the future.

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15:24

The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes. GreenMedInfo

PMID:  PLoS One. 2018 ;13(8):e0202933. Epub 2018 Aug 27. PMID: 30148860 Abstract Title:  The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes. Abstract:  In this study, we investigated the anti-microbial, anti-inflammatory, and anti-lipogenic effects of hemp (Cannabis sativa L.) seed hexane extracts, focusing on the Propionibacterium acnes-triggered inflammation and lipogenesis. Hemp seed hexane extracts (HSHE) showed anti-microbial activity against P. acnes. The expression of iNOS, COX-2, and the subsequent production of nitric oxide and prostaglandin increased after infection of P. acnes in HaCaT cells, however, upon treating with HSHE, their expressions were reduced. P. acnes-induced expressions of IL-1 and IL-8 were also reduced. HSHE exerted anti-inflammatory effects by regulating NF-B and MAPKs signaling and blunting the translocation of p-NF-B to the nucleus in P. acnes-stimulated HaCaT cells. Moreover, P. acnes-induced phosphorylation of ERK and JNK, and their downstream targets c-Fos and c-Jun, was also inhibited by HSHE. In addition, the transactivation of AP-1 induced by P. acnes infection was also downregulated by HSHE. Notably, HSHE regulated inflammation and lipid biosynthesis via regulating AMPK and AKT/FoxO1 signaling in IGF-1-induced inflammation and lipogenesis of sebocytes. In addition, HSHE inhibited 5-lipoxygenase level and P. acnes-induced MMP-9 activity, and promoted collagen biosynthesis in vitro. Thus, HSHE could be utilized to treat acne vulgaris, through its anti-microbial, anti-inflammatory, anti-lipogenic, and collagen-promoting properties.

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15:18

USA TODAY: Tennessee U.S. Rep.-elect Dr. Mark Green (MD) alleges vaccines may cause autism, questions CDC about possible fraud Health Nut News

On Tuesday, Congressman-elect, Mark Green (R) from Clarksville, Tennessee told constituents he believes vaccines may be causing autism. But he didnt stop there; Green, who is also a medical doctor, also said he believed the CDC has fraudulently managed the data. We couldnt agree more (especially on the fraud part). Let me say this about autism. []

The post USA TODAY: Tennessee U.S. Rep.-elect Dr. Mark Green (MD) alleges vaccines may cause autism, questions CDC about possible fraud appeared first on Health Nut News.

15:05

Comparison of the antimicrobial activities of four honeys from three countries. GreenMedInfo

PMID:  Front Microbiol. 2018 ;9:1378. Epub 2018 Jun 25. PMID: 29988499 Abstract Title:  Comparison of the Antimicrobial Activities of Four Honeys From Three Countries (New Zealand, Cuba, and Kenya). Abstract:  Skin and chronic wound infections are an increasing and urgent health problem worldwide. Their management is difficult and the development of antibiotic resistance by both planktonic and biofilm-associated bacteria necessitates the use of alternative treatments. The purpose of this study was to compare the antimicrobial activity of four honeys from different floral and geographical origins:honey (Cuba) and threehoneys [Manuka honey (New Zealand),honey (Cuba), and African honey (Kenya)]. The physicochemical parameters were within the ranges reported for these honeys andhoney stood out due to its acidic character. An agar incorporation technique was used to determine the minimum active dilution of each honey against 52 clinical isolates (34 Gram-positive, 17 Gram-negative, and 1). The antibiofilm activity of honeys was tested by assessing their ability to inhibit biofilm formation and to disrupt preformed biofilms. Overall,honey had the highest antimicrobial and antibiofilm activity, although a marked disruption in preformed biofilms was shared by all tested honeys. Structural changes induced byhoney onandcells were observed by transmission electron microscopy suggesting that this honey has a potent antimicrobial action and may be an excellent candidate for the development of topical preparations for the treatment of infected wounds.

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14:32

These findings indicate that honeys of various Danish floral sources may have clinical potential GreenMedInfo

n/a PMID:  Dermatol Res Pract. 2018 ;2018:7021713. Epub 2018 Jun 19. PMID: 30018636 Abstract Title:  The Antibacterial Effectof Honey Derived from Various Danish Flora. Abstract:  The mechanism behind the biologic actions of honey as a wound remedy has been intensively studied; however, there is no published data regarding any antibacterial effect of honey derived from Danish flora. We surveyed 11 honeys of various Danish floral sources for their antibacterial activity and compared them to a culinary processed commercial honey (Jakobsens) and a raw and a medical grade Manuka () honey using the agar-well diffusion method. We tested the effect on three gram-positive bacteria (two strains ofand one strain of) and two gram-negative bacteria (and). All samples, except the commercial honey, exhibited antibacterial activity, and samples derived from Water Mint (Organic 2 (mixed organic flora), and Linden () honey had consistent effects on all bacteria tested and showed greater effect than medical grade and raw Manuka () honey. The content of methylglyoxal was low in the Danish honey (<2g/mL) and significantly (p<0.05) higher in both the raw and the medical grade Manuka () honey, where the concentrations were, respectively, 6.29g/mL and 54.33g/mL. The antibacterial effect of Danish honeys was mostly due to hydrogen peroxide. We conclude that honeys derived from Danish flora possess antibacterial effect, probably by a hurdle effect of viscosity, osmolality, acidity, bioactive peptides, and most importantly the content of hydrogen peroxide. These findings indicate that honeys of various Danish floral sources may have clinical potential, although further studies are necessary to elucidate this in order to determine whether the results of ourexperiments also apply to a clinical setting.

14:26

The present study suggests that manuka honey can be used as an additional therapy for the patient with giardiasis or trichomoniasis. GreenMedInfo

PMID:  Indian J Pharmacol. 2018 Jul-Aug;50(4):197-203. PMID: 30505056 Abstract Title:  Comparative effect of manuka honey on anaerobic parasitic protozoans with standard drug therapy underconditions: A preliminary study. Abstract:  BACKGROUND: From the past five decades, metronidazole and tinidazole have been used for treating nonresistant and resistant giardiasis and trichomoniasis. However, due to the occurrence of drug resistance to standard therapy idealizes us to explore some additional therapies which is cost-effective, easy accessibility, and natural which has least side effects. Manuka honey obtained fromis well known for its antibacterial and wound healing properties and is thought to be a better option as an additional therapy.OBJECTIVE: The present study was conducted to find out the effect of manuka honey on anaerobic protozoans that includesandunderconditions in comparison to metronidazole and tinidazole.MATERIALS AND METHODS: Axenic culture ofstrain Portland 1 andstrain 413 was used for drug sensitivity assay to tinidazole, metronidazole, and manuka honey with the highest concentration of 17.1g/ml, 24.7 g/ml, and 50%v/v by using (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole). For this, head-to-head comparison has been done and ICof the standard drug as well as manuka honey was calculated.RESULTS: The result showed that percentage inhibition on the growth of both the parasites is dependent on concentration as well as exposure time of the drug. The calculated ICwas found to be 5.6%v/v and 1.5%v/v for manuka honey with respect toand.CONCLUSION: The present study suggests that manuka honey can be used as an additional therapy for the patient with giardiasis or trichomoniasis. However,study in the near future will elucidate more about the effectiveness of honey in treating parasitic infections.

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14:16

Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays. GreenMedInfo

PMID:  Nutr Neurosci. 2018 Nov 15:1-9. Epub 2018 Nov 15. PMID: 30433855 Abstract Title:  Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays. Abstract:  Stigmasterol (ST) is a multifunctional phytosterol and is found in diverse food. In our previous transcriptomics study, we found ST upregulated migration-related genes. In the present study, we carried out in vitro neurosphere migration assays to investigate the effects of ST on neuronal migration. For this purpose, neurospheres were produced by culturing rat (Sprague-Dawley) E14 cortical neurons. The addition of ST (75M) to culture medium increased not only the numbers of migratory neurons by 15% but the distance of movement up to 120m from the centers of neurospheres as compared to vehicle cultures. Immunocytochemistry and immunoblotting showed ST upregulated the expressions of Reelin (Reln) and its downstream signaling molecules like phospho-JNK (c-Jun N-terminal kinase), doublecortin (DCX) and dynein heavy chain (DHC) in migratory neurons. Furthermore, in silico molecular docking simulation indicated that ST interacts with Relin receptor ApoER2 by forming a hydrogen bond with Lys2467 and othervan der Waals interactions. Taken together, our study shows that ST upregulates Reln signaling and promotes neuronal migration and suggests that ST supplementation is considered as a potential means of treating migration-related CNS disorders.

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14:01

Vitamin C and irinotecan ameliorates colorectal cancer induced by azoxymethane and dextran sodium sulfate in mice. GreenMedInfo

PMID:  Biol Pharm Bull. 2018 ;41(12):1797-1803. PMID: 30504681 Abstract Title:  Administration of High-Dose Vitamin C and Irinotecan Ameliorates Colorectal Cancer Induced by Azoxymethane and Dextran Sodium Sulfate in Mice. Abstract:  High-dose vitamin C administration has been reported to exhibit antitumor effect in various mouse models of cancer. However, the underlying mechanism of antitumor effect against colorectal cancer remains to be elucidated. In this study, we investigated the antitumor effect of high-dose vitamin C in a mouse model of chronic inflammation-associated colorectal cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). After cancer induction, the mice were administered vitamin C and/or irinotecan. Because irinotecan is a key drug in colorectal cancer treatment, it was used for comparison in this study. We examined reactive oxygen species (ROS) and interleukin-6 (IL-6) levels in the plasma of mice, as well as collagen type I and caspase-1 expression and neutrophil and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cell counts in the colon tissue. Vitamin C and/or irinotecan administration decreased the plasma level of ROS and IL-6 and increased the expression of collagen type I and caspase-1. Furthermore, it increased neutrophil and TUNEL-positive cell counts. The most significant changes in the parameters analyzed were observed when both vitamin C and irinotecan were administered.

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12:58

Vitamin C ameliorates the adverse effects of dexamethasone on sperm motility, testosterone level, and spermatogenesis indexes. GreenMedInfo

PMID:  Hum Exp Toxicol. 2018 Dec 9:960327118816137. Epub 2018 Dec 9. PMID: 30526067 Abstract Title:  Vitamin C ameliorates the adverse effects of dexamethasone on sperm motility, testosterone level, and spermatogenesis indexes in mice. Abstract:  BACKGROUND:: Dexamethasone (DEX) is a common medicine that is capable of causing malformation in the male reproductive system. The aim of this study was to investigate the effect of vitamin C (Vit-C) on spermatogenesis indexes and daily sperm production (DSP) in adult mice treated with DEX.METHODS:: Male Naval Medical Research Institute (NMRI) mice were divided into four groups: Control, DEX (7 mg/kg/day), Vit-C (100 mg/kg/day), and DEX +Vit-C and treated for 7 days with intraperitoneal injection.RESULTS:: A significant increase in the mean levels of serum and tissue malondialdehyde (MDA) and apoptosis of Leydig cells was found in the DEX group compared to the control group. Sperm motility, DSP, tubular differentiation index, meiotic index, spermatogenesis index, the mean number of spermatocytes, round and long spermatids, and Leydig cells, and also serum testosterone level decreased in the DEX group compared to the control group. The results of this study indicate that Vit-C can significantly prevent the adverse effects of DEX on the mean number of spermatocyte, spermatid, and Leydig cells, tubular differentiation, meiotic and spermatogenesis index, DSP, sperm motility, and the mean levels of serum MDA.CONCLUSION:: In conclusion, our results showed that coadministration of Vit-C and DEX prevents the adverse effects of DEX on the spermatogenesis indexes and DSP.

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12:54

Therapeutic targets of vitamin C on liver injury and associated biological mechanisms. GreenMedInfo

PMID:  Int Immunopharmacol. 2018 Dec 5 ;66:383-387. Epub 2018 Dec 5. PMID: 30530052 Abstract Title:  Therapeutic targets of vitamin C on liver injury and associated biological mechanisms: A study of network pharmacology. Abstract:  In our previous studies, vitamin C (VC) exerts potent pharmacological activities against liver injury (LI). Therefore, this report was designed to use network pharmacology-based strategy to predict therapeutic targets of VC against LI, and further to investigate the pharmacological molecular mechanisms. Pathological targets of LI were identified, followed by acquisition of verified targets of VC. After constructing target-functional protein interaction network of VC against LI, the core therapeutic targets of VC against LI were obtained. Further, biological function and pathway enrichment analyses were performed on core therapeutic targets to evaluate the biological processes and key signaling pathways of VC against LI. As revealed in network pharmacology assays, 6 key therapeutic targets for VC against LI were identified, showing tumor necrosis factor (TNF), nuclear factor-kappa-B p65 (RELA), nuclear factor-kappa-B p105 (NFKB1), TNF receptor-associated factor 2 (TRAF2), interleukin 6 (IL-6) and interleukin 1 beta (IL1B). On the basis of data analyses from DAVID database and omicshare cloud platform, bio-functional enrichment assays showed that the therapeutic effects of VC against LI were closely associated with regulating inflammatory reaction and apoptosis. Further, pathway enrichment analysis indicated the anti-LI benefits of VC were principally implicated in regulating the top 20 signaling pathways, such as inflammation-associated TNF signaling pathway, NF-B signaling pathway. Taken together, the bioinformatics data elucidate that anti-LI pharmacological activities of VC may be predominantly related to inhibition of inflammatory stress, contributing to suppression of LI development. These resultant findings highlight the predicted therapeutic targets may be potential biomarkers for anti-LI.

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12:44

Black seed thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin-induced diabetic male wistar rats. GreenMedInfo

PMID:  Oxid Med Cell Longev. 2018 ;2018:8104165. Epub 2018 Mar 4. PMID: 29686746 Abstract Title:  Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats. Abstract:  Diabetes mellitus is one of the metabolic diseases having several complications.oil (NSO) might have beneficial effects in the treatment of diabetic complications. Thirty-two mature male Wistar rats were equally divided into four experimental groups: control, control NSO 2mL/kg, streptozotocin- (STZ-) induced diabetic, and diabetic (STZ-induced) treated with oral NSO 2mg/kg for 30 days. Fasting blood glucose (FBG), insulin, and lipid profile levels were determined. Pancreatic and hepatic tissues were used for catalase and GSH. Histopathology, hepatic glycogen contents, insulin immunohistochemistry, and pancreatic islet morphometry were performed. NSO 2mL/kg was noticed to decrease (

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12:18

Molecular inhibition mechanisms of cell migration and invasion by coix polysaccharides in A549 NSCLC cells via targeting S100A4. GreenMedInfo

PMID:  Mol Med Rep. 2017 Jan ;15(1):309-316. Epub 2016 Dec 5. PMID: 27922683 Abstract Title:  Molecular inhibition mechanisms of cell migration and invasion by coix polysaccharides in A549 NSCLC cells via targeting S100A4. Abstract:  S100 calcium binding protein A4 (S100A4) promotes extracellular signal transduction, intercellular adhesion, motility and mobility. Different extracts from Coix lachryma-jobi have been used for the treatment of various types of cancer in Asia. In our previous study, the polysaccharide fraction extact, CP1, induced cell apoptosis of nonsmall cell lung cancer cells. In the current study, CP1 inhibited migration and invasion of A549 cells in a scratch wound healing assay and matrigel invasion assay, respectively. Furthermore, reverse transcriptionpolymerase chain reaction and western blotting demonstrated that CP1 downregulated the gene and protein expression levels of S100A4. In silico docking analysis demonstrated that polysaccharides may not interfere with dimerization, whereas, the affinity of polysaccharides for an S100A4NMIIA pocket was margnially greater than at the dimerization sites. Thus, CP1 inhibited A549 cell migration and invasion potentially via downregulation of S100A4, and may also interact with the binding site of S100A4NMIIA, which indicated that CP1 has potential as an alternative cancer chemotherapeutic by targeting S100A4.

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12:03

Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth GreenMedInfo

PMID:  Sci Rep. 2017 Aug 24 ;7(1):9373. Epub 2017 Aug 24. PMID: 28839202 Abstract Title:  Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation. Abstract:  The immune system plays a critical role in exerts effects in the growth and progression of hepatocellular carcinoma (HCC), which needs interacting approaches for effective therapy. In this study, we have found that the Norcantharidin (NCTD) + Coix lacryma-jobi seed oil (CLSO) combination exhibited more potent antitumor effects in an terms of cytotoxicity and apoptotic induction in human HepG2 and HepG2/ADM cells than NCTD or CLSO alone. In vivo, administration of NCTD+CLSO combinations significantly suppressed the formation of tumor in Hepal-1 hepatoma-bearing mice. Furthermore, we found that the in vitro co-cultures of HepG2 or HepG2/ADM cells with PBMCs from healthy donors led to an increase in the number of CD4CD25T cells. This increase was down-regulated by the combination effectively. Down-regulation of FoxP3 mRNA and protein expression occurred during the combination in the co-cultures. The amount of Tregs of Hepal-1 hepatoma-bearing mice was significantly decreased in the combination treated group. The combination down-regulated the expression of FoxP3, CTLA-4 and Tregs related cytokine (TGF- and IL-10) in the serum of tumor bearing mice. Taken together, these results suggest that the most valuable aspect of the NCTD+CLSO combined use improves the anti-tumor activity and regulates tumor infiltrating Tregs.

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11:54

Adlay sprout extract has anti-metastatic activity in colon cancer cells in vitro. GreenMedInfo

PMID:  BMC Complement Altern Med. 2017 Nov 6 ;17(1):486. Epub 2017 Nov 6. PMID: 29110726 Abstract Title:  Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. Abstract:  BACKGROUND: Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf has been used in China as an herbal medicine. Many studies of this plant have reported anti-proliferative and apoptotic activities on human cancer cell lines. Therefore, this study of the anti-metastatic effect of Coix lacryma-jobi var. ma-yuen Stapf sprout extract (CLSE) in colorectal cancer cells may provide a scientific basis for exploring anti-cancer effects of edible crops.METHODS: To evaluate the effect of CLSE on cell proliferation and signaling, we performed a Cell Counting Kit-8 (CCK-8) assay in HCT116 cells and used western blot analysis. Furthermore, scratch-wound healing, transwell migration, matrigel invasion, and adhesion assays were conducted to elucidate the anti-metastatic effects of CLSE under hypoxic conditions in colon cancer cells.RESULTS: First, CLSE decreased deferoxamine (DFO)-induced migration of colon cancer cells by 87%, and blocked colon cancer cell migration by 80% compared with hypoxia control cells. Second, CLSE treatment resulted in a 54% reduction in hypoxia-induced invasiveness of colon cancer cells, and 50% inhibition of adhesive potency through inactivation of the extracellular signal-regulated kinase (ERK) 1/2 and protein kinase b (AKT) pathways. Third, conditioned medium collected from CLSE-treated HCT116 cells suppressed tube formation of human umbilical vein endothelial cells (HUVECs) by 91%.CONCLUSIONS: CLSE inhibited migration, invasion, and adhesion of colon cancer cells and tube formation by HUVECs via repression of the ERK1/2 and AKT pathways under hypoxic conditions. Therefore, CLSE may be used to treat patients with colon cancer.

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11:51

China Set to Shock Markets with Low Glyphosate Residue Limits in Food Imports Natural Blaze

 

By Sustainable Pulse

China is set to introduce maximum residue limits (MRLs) of 200 parts per billion (ppb) or lower for glyphosate in all imported final food products and raw materials including grains, soybeans and other legumes before the end of 2019, according to Sustainable Pulse sources.

The Chinese introduction of low MRLs, which are officially based on health concerns following the classification of glyphosate as a probable human carcinogen in 2015 by the International Agency for Research on Cancer, has been expected by both U.S. and Australian farming organizations for some time.

SEE: Iran Is Labeling GMOs So Is America Really The Land Of The Free?

Chinas action would likely decrease the global use of glyphosate as a desiccant. The practice, known as desiccating, pre-harvest spraying or crop topping, is favored by many conventional farmers as a way to hasten the even ripening of grains, such as wheat, oats and barley, as well as legumes and other crops such as sunflowers and potatoes, even though it is not a recommended use of the increasingly controversial weedkiller. Desiccation leads to higher levels of the herbicide in harvested crops and final food products.

In Australia the largest farming co-operative, CBH, with revenue of AUD $3.47 billion and profit of AUD $247.6 million last year, has already acted to ban desiccation according to the...

11:39

Neutralization of Naja naja venom induced lethality, edema and myonecrosis by ethanolic root extract of Coix lacryma-jobi. GreenMedInfo

PMID:  Toxicol Rep. 2017 ;4:637-645. Epub 2017 Nov 24. PMID: 29234602 Abstract Title:  Neutralization ofvenom induced lethality, edema and myonecrosis by ethanolic root extract of. Abstract:  , commonly known as job's tear, is a tall grain-bearing tropical plant of the family. The ethanolic root extract (ERE) of the plant was investigated for the first time for anti-venom activity against Indian cobravenom.studies were conducted to determine neutralization of phospholipase A(PLA) activity of thevenom by the ERE. ERE showed significant inhibition of PLAactivity, which was further confirmed from effective neutralization of human red blood cells (HRBC) lysis induced by the venom. In addition, venom-induced proteolysis, fibrinogenolysis, DNase activity were also neutralized by the ERE, which contained carbohydrates, glycolides, resins and tannins. Oral administration of ERE at doses levels 100, 200 and 400 mg/kg effectively inhibitedvenom-induced lethality in mice. Myotoxicity induced byvenom, measured by creatine kinase activity in rats was significantly neutralized by the ERE at a dose of 200 mg/kg. Stigmasterol, as one of the component isolated from the ERE, was found to have venom phospholipase Ainhibition potential, which was confirmed by molecular docking studies with PLA. In summary, these studies indicate the ability of ERE ofto effectively neutralize the toxic effects of the venom is, in part, contributed by the inhibition of PLAactivity among other venom-derived factors.

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11:35

Adlay and cisplatin led to pronounced antitumor activity in mice with Lewis lung carcinoma. GreenMedInfo

PMID:  Iran J Public Health. 2018 Jun ;47(6):838-843. PMID: 30087869 Abstract Title:  The Effects of Combination of Coix Seed Extract and Cisplatin on TAM and Expression of HIF-1 in Vivo in Lewis Lung Carcinoma. Abstract:  Background: We investigated the combined effects of Kanglaite (KLT) and cisplatin on tumor associated macrophage (TAM) and expression of hypoxia inducible factor-1 alpha (HIF-1) in Kunming mice with Lewis lung carcinoma.Methods: Kunming mice with Lewis lung carcinoma were randomly divided into four groups: the control (NS) group, KLT group, cisplatin (DDP) group and DDP+KLT group in Hebei People's Hospital, Hebei China from 2016 to 2017. Tumors were harvested 14 days after corresponding interventions.Results: The percentage of TAM was determined by flow cytometry and HIF-1 mRNA was detected by realtime-PCR. Tumor weight of mice in KLT group, DDP group and DDP+KLT group was significantly lower than that of NS group (

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11:25

Adlay ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin. GreenMedInfo

PMID:  Phytomedicine. 2018 Aug 1 ;47:69-80. Epub 2018 Mar 21. PMID: 30166110 Abstract Title:  Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin. Abstract:  BACKGROUND: Cancer has remained among the top ten causes of death in Taiwan since 1982. Uterine sarcoma is a rare gynecologic cancer, and chemotherapy is one type of cancer treatment. Doxorubicin (Dox) is widely used for treating several cancers, including uterine sarcoma, however, multidrug resistance (MDR) is a major clinical problem and a critical cause of treatment failure. The ethanolic extracts of adlay testa (ATE) exhibited significant anticancer activities against many cancer types.PURPOSE: In this study we investigated the antitumor effects of the hexane fraction of the adlay testa ethanolic extracts (ATE-Hex) on the human uterine sarcoma cancer cell line MES-SA, as well as on the multidrug-resistant human uterine sarcoma cancer cell line MES-SA/Dx5.METHODS: The MTT assay was performed to assess the effects of the extracts of different parts of the adlay on the proliferation of human uterine sarcoma cells (MES-SA and MES-SA/Dx5) and human uterine smooth muscle cells (HUtSMCs). To determine whether ATE-Hex has a chemosensitizing effect on drug-resistant uterine sarcoma cells, the MTT assay was performed to examine the synergistic effects of ATE-Hex, the chemotherapeutic drug Dox alone, and in combination. Rhodamine accumulation was analyzed using fluorescence detection. Apoptotic cells were analyzed via flow cytometry. In addition, employing a flame ionization detector (GC/FID) gas chromatography was also developed as the analysis platform for ATE-Hex.RESULTS: The results demonstrated that ATE-Hex exhibited the best effects of inhibition on MES-SA and MES-SA/Dx5 cells. Co-treatment of ATE-Hex and Dox could synergistically inhibit the proliferation of cancer cells. ATE-Hex reduced the rhodamine efflux in MES-SA/Dx5 cells, indicating that ATE-Hex could reduce the expression of P-gp. In addition, our results showed that treatment with ATE-Hex alone or in combination with Dox significantly inhibited the growth of cancer cells and induced apoptosis by increasing the sub-G1 phase and poly(ADP-ribose) polymerase (PARP) being cleaved. Flow cytometry revealed that ATE-Hex induced apoptosis.CONCLUSION: These results suggest that ATE-Hex can inhibit human uterine sarcoma cancer cells by inducing apoptosis and increasing the chemosensitivity of the multidrug-resistant human uterine sarcoma cancer cell MES-SA/Dx5 to Dox. Furthermore, the combination of ATE-Hex and Dox could decrease MDR and increase the synergistic effect.

...

11:17

This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the adlay liposomal formulation. GreenMedInfo

PMID:  J Nanosci Nanotechnol. 2019 Apr 1 ;19(4):1996-2007. PMID: 30486940 Abstract Title:  Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Linn.) Fractions. Abstract:  Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the ICvalue of 4.442.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.450.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO technique which can be further developed towards a novel anticancer drug.

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10:58

Ayahuasca may have potential as a valuable therapeutic tool in the healing of eating disorders. GreenMedInfo

PMID:  Eat Weight Disord. 2018 Nov 24. Epub 2018 Nov 24. PMID: 30474794 Abstract Title:  An exploratory study of experiences with conventional eating disorder treatment and ceremonial ayahuasca for the healing of eating disorders. Abstract:  PURPOSE: Ayahuasca is a traditional Amazonian medicine that is currently being researched for its potential in treating a variety of mental disorders. This article reports on exploratory qualitative research relating to participant experiences with ceremonial ayahuasca drinking and conventional treatment for eating disorders (EDs). It also explores the potential for ayahuasca as an adjunctive ED treatment.METHODS: Thirteen individuals previously diagnosed with an ED participated in a semi-structured interview contrasting their experiences with conventional ED treatment with experiences from ceremonial ayahuasca. The interviews were analyzed using thematic analysis.RESULTS: Participant reports were organized with key themes including that ayahuasca: led to rapid reductions in ED thoughts and symptoms; allowed for the healing of the perceived root of the ED; helped to process painful feelings and memories; supported the internalization of greater self-love and self-acceptance; and catalyzed spiritual elements of healing.CONCLUSIONS: The results suggest that ayahuasca may have potential as a valuable therapeutic tool, and further research-including carefully controlled clinical trials-is warranted.LEVEL OF EVIDENCE: Level V, qualitative descriptive study.

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10:37

The results indicated that the growth of lung cancer cells A549 might be inhibited with Spica prunellae through activating the proapoptotic protein caspase-3. GreenMedInfo

PMID:  J Cancer Res Ther. 2018 ;14(4):760-763. PMID: 29970649 Abstract Title:  Effects ofon caspase-3-associated proliferation and apoptosis in human lung cancer cells. Abstract:  Purpose: This study aimed to explore the molecular mechanisms underlying the effects of Spica prunellae on proliferation and apoptosis of lung cancer cells in vitro.Materials and Methods: The cell viability was determined with the CCK8 assay and the apoptosis was examined by flow cytometry. Western blotting was applied to detect the protein level of caspase-3 expression.Results: It was observed that Spica prunellae could promote the apoptosis and inhibit the proliferation of A549 in vitro. The analysis of Western blotting showed that the expression level of proapoptosis protein caspase-3 was generally unchanged, whereas the level of activated caspase-3 was significantly increased.Conclusion: The results indicated that the growth of lung cancer cells A549 might be inhibited with Spica prunellae through activating the proapoptotic protein caspase-3 and inducing cellular apoptotic pathway.

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10:33

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection. GreenMedInfo

PMID:  Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426 Abstract Title:  Antimicrobial activity ofextracts against multi-drug resistantfrom patients of urinary tract infection. Abstract:  Background and Objective: is the most common etiological agent of UTI and accounts for more then 100, 0000 hospitalization annually. The objective of this study was to investigate the antimicrobial activity of aqueous and ethanolic extracts ofagainstfrom urinary tract infection patients.Methods: Urine samples of forty four suspected patients from Tertiary Care Hospital Faisalabad were used in this study. Ethanolic and aqueous extracts of(PV), a medicinal plant was evaluated for its ability to inhibit the growth of 38 resistant isolates ofstrains and compared to Ciprofloxacin, Ofloxacin, Cefixime and Tobramycin by well diffusion method. Minimum inhibitory concentration was measured by using broth micro dilution method.Results: PV showed antibacterial activity againststrains, however Tobramycin at 10 microgram (10g) inhibited the resistantto a greater extent as compared to other antibiotics and was resistant to twice less number of strains, about 82% ofisolates have MDR pattern.Conclusion: Ciprofloxacin has more efficacy than PV and no synergistic effect with extracts of PV. Cefixime is least efficacious against resistant, however it has synergistic effect with extracts of PV.

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10:31

Massachusetts Seeks to Disbar and Silence Attorney Fighting to Expose Corruption in Senior Medical Kidnappings Health Impact News

Lisa Belanger and father

Marvin Siegel and Daddys girl Lisa Belanger, before guardians took them away from each other. Photo provided by family.

Commentary by Terri LaPoint
Health Impact News

Attorneys and guardians have plundered the estate of Marvin Siegel, a retired attorney from Boxford, Massachusetts. At the same time they have gone through the courts to isolate him from his children and essentially imprison him in his own home.

His youngest daughter Lisa Belanger followed in his footsteps in becoming an attorney, inspired by her fathers principles of fighting for what is right. She says:

He taught me to not be silent when wrongs are being done to others.

She and her sister Devora Kaiser were shocked to see the strong arm of the state in keeping them away from their beloved father when he was captured from his family in 2011.

See their original story:

Massachusetts Senior Citizen and Attorney Medically Kidnapped Estate Plundered Represents National Epidemic

Marvin Siegels daughters had no idea how deeply the corruption in the guardianship issue runs, but they have had a front row seat to see the conflicts of interests, sweetheart deals, drugging of senior citizens, and raping of their estates that are standard fare in some probate courts, such as the one their family has had the misfortune of being subjected to.

According to the Boston Broadside:

In March of 2015, Marvins daughter, Attorney Lisa Siegel Belanger, filed an extensive federal civil action in which she claims that Atty.

Kazarosian is part of a long-embedded insidious enterprise of corrupt lawyers and judges using the Massachusetts Probate & Family Court system to exploit eldersand any person of any age for that matter who happen to be vulnerably labeled as incapacitated.

Lisas extensive, detailed complaint and accompanying exhibits can be viewed by the public free of charge at...

10:09

Massachusetts Seeks to Disbar and Silence Attorney Fighting to Expose Corruption in Senior Medical Kidnappings Medical Kidnap

Lisa Belanger and father

Marvin Siegel and Daddys girl Lisa Belanger, before guardians took them away from each other. Photo provided by family.

Commentary by Terri LaPoint
Health Impact News

Attorneys and guardians have plundered the estate of Marvin Siegel, a retired attorney from Boxford, Massachusetts. At the same time they have gone through the courts to isolate him from his children and essentially imprison him in his own home.

His youngest daughter Lisa Belanger followed in his footsteps in becoming an attorney, inspired by her fathers principles of fighting for what is right. She says:

He taught me to not be silent when wrongs are being done to others.

She and her sister Devora Kaiser were shocked to see the strong arm of the state in keeping them away from their beloved father when he was captured from his family in 2011.

See their original story:

Massachusetts Senior Citizen and Attorney Medically Kidnapped Estate Plundered Represents National Epidemic

Marvin Siegels daughters had no idea how deeply the corruption in the guardianship issue runs, but they have had a front row seat to see the conflicts of interests, sweetheart deals, drugging of senior citizens, and raping of their estates that are standard fare in some probate courts, such as the one their family has had the misfortune of being subjected to.

According to the Boston Broadside:

In March of 2015, Marvins daughter, Attorney Lisa Siegel Belanger, filed an extensive federal civil action in which she claims that Atty.

Kazarosian is part of a long-embedded insidious enterprise of corrupt lawyers and judges using the Massachusetts Probate & Family Court system to exploit eldersand any person of any age for that matter who happen to be vulnerably labeled as incapacitated.

Lisas extensive, detailed complaint and accompanying exhibits can be viewed by the public free of charge at...

10:00

The mechanisms by which N. sativa impede progression in chronic liver diseases should be used as a preventive medicine in patients with hepatic disorders. GreenMedInfo

PMID:  Curr Pharm Biotechnol. 2018 ;19(1):43-67. PMID: 29701149 Abstract Title:  Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review. Abstract:  The pharmacological properties of Nigella sativa L. are well attributed to the presence of bioactive compounds, mainly, thymoquinone (TQ), thymol (THY) and hederin and their antioxidant effects. TQ, THY and alpha-hederin (-hederin) provide protection to liver from injury via different mechanisms including inhibition of iron-dependent lipid peroxidation, elevation in total thiol content and (GSH) level, radical scavenging, increasing the activity of quinone reductase, catalase, superoxide dismutase (SOD) and glutathione transferase (GST), inhibition of NF-B activity and inhibition of both (COX) and (LOX) protects liver from injuries. Review and Conclusion: The main aim of this literature review is to reflect the relevant role of ROS in inducing hepatic diseases and also the preventive role of N. sativa L. in hepatic diseases. The present article is directed towards highlighting the beneficial contribution of researchers to explore the pharmacological actions with therapeutic potential of this precious natural herb and its bioactive compounds pertaining to the hepatoprotective effects. We systematically searched for research literature through well-framed review question and presented the data in the tabular forms for the convenience of the readers. Two hundred and forty-one papers were embodied in this review, oxidative effect and the reactive oxygen species (ROS) are known to be the major causes of many diseases such as hepatic cancer. Many drugs and chemicals have shown to incite oxidative damage by generation of ROS in the body. Therefore, this review intends to focus the role of ROS in liver diseases and the mechanismsthrough which N. sativa prevents hepatic diseases. The mechanisms by which N. sativa impede progression in chronic liver diseases should be used as a preventive medicine in patients with hepatic disorders.

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09:41

Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity. GreenMedInfo

PMID:  Biotech Histochem. 2018 ;93(6):453-462. Epub 2018 Apr 27. PMID: 29701106 Abstract Title:  Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity. Abstract:  We investigated changes in rat liver tissues following administration of thymoquinone (TQ) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hepatotoxicity. Fifty rats were assigned randomly to five groups of 10 as follows: control, corn oil, TCDD, TQ and TCDD + TQ. Biochemical and histopathological analyses were conducted on liver tissue. We found that 30 day TCDD administration caused histopathological changes in liver including thickening of Glisson's capsule, intracytoplasmic vacuolization in hepatocytes, sinusoidal dilation, vascular and sinusoidal congestion and inflammatory cell infiltration. TCDD administration increased malondialdehyde (MDA), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels in rat liver tissue and reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels compared to all other groups. In the TQ treated group, GSH, SOD, CAT and TAS levels increased compared to all other groups. MDA, TOS, ALT, AST, ALP levels decreased compared to all other groups. Our histological findings were consistent with the biochemical findings. The oxidative and histologic effects of TCDD were eliminated by TQ treatment. TCDD administration caused oxidative stress in rat liver and TQ administered with TCDD prevented TCDD induced hepatotoxicity. TQ could be considered an alternative anti-TCDD toxicity agent.

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09:23

Why Do Vitamin B12 Supplements Contain Cyanide? GreenMedInfo

What's cyanide doing in vitamin B12 supplements, and is it doing the body any good,  or possibly harm? 

Unknown to most consumers, cyanide is found in a wide range of vitamins and foods in a form known as cyanocobalamin. Fortunately the cyanide has a very low potential to do harm because it is organically bound to cobalamin (vitamin b12) -- that is, as long as everything is working correctly and that person hasn't already been burdened with environmental chemical exposures from cyanide, and related xenobiotic compunds.

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09:10

Thymoquinone can also regulate IRF-3, one of the inflammatory transcription factors, providing a novel insight into its anti-inflammatory activities. GreenMedInfo

PMID:  Int J Mol Sci. 2018 May 3 ;19(5). Epub 2018 May 3. PMID: 29751576 Abstract Title:  Thymoquinone Suppresses IRF-3-Mediated Expression of Type I Interferons via Suppression of TBK1. Abstract:  Interferon regulatory factor (IRF)-3 is known to have a critical role in viral and bacterial innate immune responses by regulating the production of type I interferon (IFN). Thymoquinone (TQ) is a compound derived from black cumin (L.) and is known to regulate immune responses by affecting transcription factors associated with inflammation, including nuclear factor-B (NF-B) and activator protein-1 (AP-1). However, the role of TQ in the IRF-3 signaling pathway has not been elucidated. In this study, we explored the molecular mechanism of TQ-dependent regulation of enzymes in IRF-3 signaling pathways using the lipopolysaccharide (LPS)-stimulated murine macrophage-like RAW264.7 cell line. TQ decreased mRNA expression of the interferon genesandin these cells. This inhibition was due to its suppression of the transcriptional activation of IRF-3, as shown by inhibition of IRF-3 PRD (III-I) luciferase activity as well as the phosphorylation pattern of IRF-3 in the immunoblotting experiment. Moreover, TQ targeted the autophosphorylation of TANK-binding kinase 1 (TBK1), an upstream key enzyme responsible for IRF-3 activation. Taken together, these findings suggest that TQ can downregulate IRF-3 activation via inhibition of TBK1, which would subsequently decrease the production of type I IFN. TQ also regulated IRF-3, one of the inflammatory transcription factors, providing a novel insight into its anti-inflammatory activities.

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08:59

Nano-formulated thymoquinone suspension can efficiently culminate 3-NP induced Huntington's disease progression. GreenMedInfo

PMID:  Metab Brain Dis. 2018 Oct ;33(5):1459-1470. Epub 2018 May 31. PMID: 29855977 Abstract Title:  Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington's disease. Abstract:  Defect in gene transcription, excitotoxicity, neuroinflammation and oxidative stress are the dominant disease process that causes striatal cell loss with motor abnormalities in Huntington's disease (HD). Homogeneous pathological reminiscent of HD was extrapolated in the present study using a potent mitochondrial toxin, 3-Nitropropionic acid (3-NP). Administration of 3-NP for 14 days in the present study portends glial cell activation, N-methyl-D-aspartate (NMDA) receptor stimulation, neuroinflammation and motor deficits. The therapeutic strategy in the present study was improvised by formulating thymoquinone, a biologically active compound into a colloidal carrier namelysolid lipid nanoparticles. Treatment with 10 and 20 mg/kg b.w of thymoquinone loaded solid lipid nanoparticles (TQ-SLNs) and 80 mg/kg b.w of thymoquinone suspension (TQ-S) showed a significant (P

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08:36

Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats. GreenMedInfo

PMID:  Drug Des Devel Ther. 2018 ;12:1347-1352. Epub 2018 May 22. PMID: 29861626 Abstract Title:  Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats. Abstract:  Aim: The aim of this study was to investigate the effects of levosimendan and thymoquinone (TQ) on lung injury after myocardial ischemia/reperfusion (I/R).Materials and methods: Twenty-four Wistar albino rats were included in the study. The animals were randomly assigned to 1 of 4 experimental groups. In Group C (control group), left anterior descending artery was not occluded or reperfused. Myocardial I/R was induced by ligation of the left anterior descending artery for 30 min, followed by 2 h of reperfusion in the I/R, I/R-levosimendan (24g/kg) (IRL) group, and I/R-thymoquinone (0.2 mL/kg) (IRTQ) group. Tissue samples taken from the lungs of rats were histochemically stained with H&E and immunohistochemically stained with p53, Bcl 2, Bax, and caspase 3 primer antibodies.Results: Increased expression of p53 and Bax was observed (4+), especially in the I/R group. In IRTQ and IRL groups, expression was also observed at various locations (2+, 3+). H&E staining revealed that that the lungs were severely damaged and the walls of the alveoli were too thick, the number of areas examined was increased during the evaluation. Caspase 3 expression was observed to be at an (1+, 2+) intensity that was usually weak and diffuse in multiple areas. Bcl 2 was not found to be expressed in any of the tissues. H&E staining revealed that that the lungs were severely damaged in the I/R group, with the walls of the channels and alveoli thickened and edematous, and also an intense inflammatory cell migration was observed. Immunohistochemical staining was more prominent in inflammatory areas and structures around the terminal bronchioles.Conclusion: The findings in our study have shown that administration of levosimendan and TQ during I/R increases expression of caspase 3, p53, and Bax in lung tissue and has a protective effect on lung as distant organ. We suggest that findings of this study be elucidated with further large-scale clinical studies.

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07:49

Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity. GreenMedInfo

PMID:  Life Sci. 2018 Aug 15 ;207:461-470. Epub 2018 Jun 6. PMID: 29885348 Abstract Title:  Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity. Abstract:  AIMS: This study aimed to elucidate the benefits of nanoformulation of doxorubicin (DOX) and thymoquinone (TQ) loaded with nanofibers of poly-N-acetyl glucosamine (pGlcNAc), which is known as F2 gel, over their conventional free forms. Moreover, evaluate the role of TQ in improving chemotherapeutic effect and ameliorating nephrotoxicity of DOX.MAIN METHODS: The drugs were loaded into F2 gel followed by measurement of physicochemical characterization. Next, MCF-7 and HEPG2 cells were treated with the prepared formulations and assessed for apoptosis alongside with cellular proliferation. Furthermore, we experimentally induced Heps liver carcinoma in mice and at the end of the treatment, mice were sacrificed and serum samples were used to assess nephrotoxicity markers; blood urea nitrogen (BUN) and creatinine. Additionally, renal tissue was used for determination of oxidative markers and antioxidant enzymes; whereas, tumor tissue was utilized to measure nuclear factor kappa B (NF-B) and caspase 3.KEY FINDINGS: Nanoformulation showed dramatic increase in apoptosis, caspase 3, and antioxidant enzymes; in contrast to, dramatic fall in cell viability, tumor volume, oxidative and nephrotoxicity markers, and NF-B compared to corresponding free therapies. Combined therapy was superior in conserving the measured parameters compared to other treated groups.SIGNIFICANCE: F2 gel loaded with DOX and TQ revealed enhanced antitumor activity with minimal toxicity. Moreover, using TQ as an adjuvant with DOX could augment its cytotoxicity and ameliorate nephrotoxicity.

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07:36

Vegan NBA star John Salley invests in plant-based pesticide to rival Monsanto/Bayer Health Nut News

John Salley, the four-time NBA champion, vegan, and wellness entrepreneur has decided to buy a stake in the plant-based pesticide company, PureCrop1. Besides his financial support, he will also act as a spokesperson. Speaking about the partnership, Salley said, I have successfully invested in several early-stage companies and feel PureCrop1 is a game changer, valuable []

The post Vegan NBA star John Salley invests in plant-based pesticide to rival Monsanto/Bayer appeared first on Health Nut News.

07:35

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells. GreenMedInfo

PMID:  Oncotarget. 2018 Jun 19 ;9(47):28599-28611. Epub 2018 Jun 19. PMID: 29983883 Abstract Title:  Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells. Abstract:  Down-regulation of UHRF1 (Ubiquitin-like containing PHD and Ring Finger 1) in Jurkat cells, induced by natural anticancer compounds such as thymoquinone, allows re-expression of tumor suppressor genes such asand. In order to decipher the mechanisms of UHRF1 down-regulation, we investigated the kinetic of expression of HAUSP (herpes virus-associated ubiquitin-specific protease), UHRF1, cleaved caspase-3 and p73 in Jurkat cells treated with thymoquinone. We found that thymoquinone induced degradation of UHRF1, correlated with a sharp decrease in HAUSP and an increase in cleaved caspase-3 and p73. UHRF1 concomitantly underwent a rapid ubiquitination in response to thymoquinone and this effect was not observed in the cells expressing mutant UHRF1 RING domain, suggesting that UHRF1 commits an auto-ubiquitination through its RING domain in response to thymoquinone treatment. Exposure of cells to Z-DEVD, an inhibitor of caspase-3 markedly reduced the thymoquinone-induced down-regulation of UHRF1, while proteosomal inhibitor MG132 had no such effect. The present findings indicate that thymoquinone induces in cancer cells a fast UHRF1 auto-ubiquitination through its RING domain associated with HAUSP down-regulation. They further suggest that thymoquinone-induced UHRF1 auto-ubiquitination followed by its degradation is a key event in inducing apoptosis through a proteasome-independent mechanism.

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06:33

Forget cholesterol, this is what will stop your heart Health Nut News

(Click here to listen to the Nourish Balance Thrive podcast. On you arrive to the page, simply click the play bottom at the top of the article.) Cholesterol is a waxy substance found in nearly every cell of your body and is essential to good health. It plays a role in hormone production, digestion and []

The post Forget cholesterol, this is what will stop your heart appeared first on Health Nut News.

06:00

Indiana University paper about lung transplantation retracted after misconduct finding Retraction Watch

After a finding of data manipulation, the corresponding author of a 2014 paper by a team of researchers at Indiana University has retracted the work. Heres the notice in Science Translational Medicine: Science Translational Medicine is retracting the Research Article The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation by Weber et Continue reading Indiana University paper about lung transplantation retracted after misconduct finding

03:44

DIY Bergamot, Ginger, Apple Cider Vinegar Tea Tonic REALfarmacy.com

Source: DIY Bergamot, Ginger, Apple Cider Vinegar Tea Tonic For more content like this visit REALfarmacy.com.

By Dr. Mercola Ginger water, apple cider vinegar and bergamot oil are all known for their health benefits, so what could be better than combining them all into a tasty tea tonic that can be consumed hot or cold? A simple recipe to try is as follows: Health-Boosting Ginger, Bergamot and Apple Cider Vinegar Tonic []

Source: DIY Bergamot, Ginger, Apple Cider Vinegar Tea Tonic Learn more at REALfarmacy.com - Healthy News and Information.

03:28

NYT: Rockefeller University Hospital knew their doctor was sexually abusing child patients for years Health Nut News

In September, Rockefeller University Hospital, a prominent New York research institution, sent out letters to former patients of Dr. Reginald Archibald, an endocrinologist, asking about their contact with him. You see, for almost 30 years, parents would seek him and his clinic out when their children didnt grow. However, it seems now that besides treating []

The post NYT: Rockefeller University Hospital knew their doctor was sexually abusing child patients for years appeared first on Health Nut News.

03:20

Healthfood Store Elderberry Syrup and Gummies. Worth the Price? The Healthy Home Economist

healthfood store elderberry syrup and gummiesWhen cooler weather arrives, you know that its that time of year once again. Coughs, cold and flu start flying around faster than in-laws and second cousins for family reunions and holiday remembrances. You know what else is flying? Bottles of elderberry syrup, gummies, and related products off healthfood store shelves.

The post Healthfood Store Elderberry Syrup and Gummies. Worth the Price? appeared first on The Healthy Home Economist.

02:57

Chlamydia A Stealth Pathogen Lyra Nara Natural Remedies

Many of us have heard about Chlamydia as a very common STD, but few are aware that Chlamydia comes in

02:40

Why is this short FAN video so popular? Fluoride Action Network

Over 126,000 people have viewed a new Fluoride Action Network video posted only a month ago and the view count continues to rise. Others in the same series only managed 4-7,000 hits. Below, we ask why this particular video is so popular, and how we might reproduce that popularity with other videos.

But first, here is an update on our annual fundraiser.  Yesterday, we received $286 from 3 donors, bringing our grand total to $72,914 from 132 supporters. To help us move a little faster to our mini-goal of $100,000 by Christmas Eve, the next $1000 donated will be doubled by one of long-term supporters.

Thank you to everyone who has already donated towards our 2019 campaign and we are hoping that more of you will join in today to increase both the $ total and also the number of donors.

Please note that we have another challenge pledge in place which will give us $200 when we reach 200 donors, $300 when we reach 300 donors and so on right up to 1000 donors!

How to make a tax-deductible donation to FAN:

  • Online at our secure server.
  • Or by Check, payable to the Fluoride Action Network. Send your check to:

    Fluoride Action Network
    c/o Connett
    104 Walnut Street
    Binghamton NY 13905

*Please note that some corporations match tax deductible donations made by their employees to some non-profits. We qualify for this. This is the information to provide your corporation finance people: FAN is a project of the American Environmental Health Studies Project, Inc, registered in Tennessee.

Why is this Short FAN Video so Popular?

In 2018, the Fluoride Action Network (FAN) created a new video series entitled Fluoride Fundamentals to provide the public and decision-makers with a basic understanding of fluoride, to dispel myths surrounding fluoridation, and answer common questions. The videos are short, engaging, science-focused, and meant to be shared far and wide, which is exactly what happened with all of them, and one in particular.

Our most recent video, Fluoride Fundamentals #4: Sources of Fluoride has been viewed over 125,500 times on Facebook, and an additional 500 times on YouTube (shared on Twitter and in bulletins).  Combined views for our four videos in the series are nearing 150,000 in just a few short months since their creation.

FLUORIDE FUNDAMENTALS VIEW COUNT:
#1       Facebook: 5,600        YouTube: 1,016...

02:35

Childhood Bipolar Disorder, Deconstructed Mad In America

 

All psychiatric diagnoses are suspect, insofar as they are descriptive and not explanatory. To say that an adult is having a manic episode is simply to provide a name for certain observable behaviors: for instance, that she is running naked down the corridors of her apartment building or staying up all night, night after night, to paint and repaint the walls of her bedroom.

That this particular naming makes sense is even less true for the mania that is supposedly a part of juvenile or pediatric bipolar disorder. There, all we might be seeing in the above behavior is an ordinary two-year-old rushing from activity to activitypractically a defining feature of being two years old. To call that behavior a symptom of the mental disorder of juvenile bipolar disorder is neither logical nor legitimate.

Have you ever been around a two-year-old? Dont they sometimes melt down and have ferocious tantrums? Dont they sometimes suffer from excesses of energy? Cant they sometimes become inconsolably sad? Arent they sometimes willful and defiant? Yet all of these states and behaviors, as completely normal and ordinary as they are, are now deemed symptoms of the mental disorder of juvenile bipolar disorder. Does this make sense?

As Stuart Kaplan, author of Your Child Does Not Have Bipolar Disorder, explained in an essay in Newsweek:

I have been a child psychiatrist for nearly five decades and have seen diagnostic fads come and go. But I have never witnessed anything like the tidal wave of unwarranted enthusiasm for the diagnosis of bipolar disorder in children that now engulfs the public and the profession. Before 1995, bipolar disorder, once known as manic-depressive illness, was rarely diagnosed in children. Today, nearly one-third of all children and adolescents discharged from child psychiatric hospitals are diagnosed with the disorder and medicated accordingly. The rise of outpatient office visits for children and adolescents with bipolar disorder increased 40-fold from 20,000 in 199495 to 800,000 in 200203. A Harvard child-psychiatry group led by Dr. Joseph Biederman, a prominent supporter of the diagnosis, recently insisted, Juvenile bipolar disorder is a serious illness that is estimated to affect approxim...

02:15

5 Ways to Take CBD and When Each is Most Beneficial Natural Blaze

By Sofia Adamson

Cannabidiol (CBD) is the critical non-psychoactive, therapeutic chemical thats present in strains of the hemp and cannabis plants. The compound is a cannabinoid, one of more than 100 rare substances that engage with the human bodys endocannabinoid system (ECS). This system plays an important role in regulating our physical and emotional wellbeing, as cannabinoid scientists have demonstrated since the late 20th century.

While there is still a way to go before doctors fully embrace and prescribe CBD to patients, hemp-derived products are already available in the United States and elsewhere. Moreover, they are quickly becoming popular due to their effectiveness. As the CBD industry evolves, manufacturers are eager to bring innovative and exciting products to market and capitalize on CBDs array of health benefits.

Below well review some of the most popular ways to take CBD. Well also detail when each consumption method may be most appropriate and the conditions it may address.

1. CBD vape oil and e-liquid

Vaporizing, or  vaping for short, has taken off over the past few years because studies have shown that it is much safer to vape than smoke. However, the following information is also applicable to those who prefer to smoke their CBD-rich hemp flower in an old-school joint or pipe.

The primary advantage of vaporizing CBD is that it offers the ultimate speed of delivery. Within seconds of taking your fir...

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Saturday, 08 December

17:09

19 Things Your Body Can Tell You About Your Health Healthy Holistic Living

Your body is a truly amazing machine. Not only is it working 24/7 just to keep you alive, but it can also send you signs when somethings wrong with your health. If you pay close attention to these 19 signs, you might just be able to find the cause before your next doctors visit. 19... View Article

The post 19 Things Your Body Can Tell You About Your Health appeared first on Healthy Holistic Living.

10:17

The Prophecy Of The Rainbow Warriors Healthy Holistic Living

Native American legends are a truly beautiful thing. Traditional stories, myths, and prophecies are passed down from generation to generation for entertainment, guidance, and culture. Hearing a Native American legend always makes me wonder about the first time it was told. Perhaps by a Native American chief standing beside a crackling fire, or under the... View Article

The post The Prophecy Of The Rainbow Warriors appeared first on Healthy Holistic Living.

Wednesday, 05 December

13:26

How To Control Blood Sugar Naturally (Without Medicine) Healthy Holistic Living

A funny thing happens sometimes when a meal is delayed. Maybe the shopping took a little longer than planned, the waiter seemed to be taking his sweet time, or the hours simply rushed by faster than expected. Whatever the circumstance, the result is always the same: we get hangry. If you arent one of the... View Article

The post How To Control Blood Sugar Naturally (Without Medicine) appeared first on Healthy Holistic Living.

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