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Saturday, 19 May

23:39

Weekend reads: How to get away with scientific fraud; whats wrong with nutrition research; a second chance after misconduct Retraction Watch

Before we present this weeks Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured a collaboration with Undark looking at how scientists who commit Continue reading Weekend reads: How to get away with scientific fraud; whats wrong with nutrition research; a second chance after misconduct

20:13

UN Meeting on Human Rights in Mental Health: A Response Mad In America

On May 14 and 15, the UN Office of the High Commissioner for Human Rights (OHCHR) held a meeting on human rights in mental health, responding to Resolution 36/13 of the Human Rights Council. The meeting was webcast and archived videos are available in three parts: day 1 morning, day 1 afternoon, and day 2, following this agenda; the main page also has links to written presentations and speaker bios.

The event represented tensions in the United Nations between the promotion of mental health and the promotion and realization of the human rights of people with psychosocial disabilities under the Convention on the Rights of Persons with Disabilities (CRPD). Development-focused agencies and member states have emphasized mental health promotion, which has of course always included force and coercion and legislation to restrict our rights and regulate the restrictions. Before the CRPD, human rights in mental health meant the regulation of rights restrictions, and providing access to tribunals to challenge the restrictions. CRPD brought in an entirely different regime that calls for an absolute prohibition of deprivation of liberty in mental health services and absolute prohibition of forced treatment; this is underpinned by recognition of legal capacity as a universal right to make decisions that, at least with respect to adults, cannot be restricted.

Speakers at the recent meeting were mixed as to where they fell. Those who are people with psychosocial disabilities or users and/or survivors of psychiatry uniformly came with the message that our human rights do not belong inside the context of mental health we have a right to autonomy and full inclusion in our societies, and the laws allowing for restriction of our rights need to be repealed; coercion cannot be reformed, it must be abolished. YeniRosa Damayanti spoke from civil society in the opening panel, Bhargavi Davar in a panel on mental health as a human rights issue, Olga Runciman (speaking as a psychologist and acknowledging her lived experience) and Michael Njenga spoke in a panel on human rights based services and supports. Jolijn Santegoeds...

20:01

Treatment-Resistant Depression as a Sign of Unconscious Health Mad In America

In this video, Dr. Elio Frattaroli describes how biological explanations for treatment-resistant depression often ignore the meaning and context of a patients suffering. He argues that the notion of treatment-resistant depression often reflects the clinicians resistance to feeling empathy for and sharing a patients emotional pain, rather than the patients own resistance to treatment.

20:00

"Prehistoric Autism Neurodiversity" AGE OF AUTISM

I just completed the paperwork to send my gorgeous almost 22 year old to day program for the severely disabled. She can watch Wonder Pets for 24 hours straight. I can't even begin to tackle this argument for "prehistoric" autism,...

15:00

What Happens to Your Body When You Eat Gluten? Articles

The word gluten has become such a buzzword in recent years, most likely because of the sudden popularity of the gluten-free diet thats been endorsed by famous personalities. Before you consider trying this diet, read this page first to learn about gluten, and how it can negatively impact your body and health in the long run.

What Is Gluten?

A type of protein, gluten is composed of glutenin and gliadin molecules that form an elastic bond when mixed with water. Gluten is highly noted for its adhesive abilities that can maintain a compact structure for holding bread and cakes together, and providing a spongier texture. This ability isnt surprising, considering that the word gluten is derived from the Latin word for glue.

While it does wonders for these foods, the same cannot be said for your body. Research has shown that gluten can be quite harmful for you because of the vast range of complications it might cause (more on this to come in a while).

What Does Gluten Do to Your Body?

A major caveat linked to gluten is its tendency to impede proper nutrient breakdown and absorption from foods, regardless if they have gluten or not. This may prevent proper digestion because excess gluten leads to the formation of a glued-together constipating lump in the gut. Afterward, the undigested gluten prompts the immune system to attack the villi, or the fingerlike projections lining your small intestine.1 This may lead to side effects such as  diarrhea or constipation, nausea and abdominal pain.

Excessive gluten consumption and further small intestine damage and inflammation may predispose a person to nutrient malabsorption, nutrient deficiencies, anemia, osteoporosis, other neurological or psychological diseases, and complications linked to the skin, liver, joints, nervous system and more.

What Are the Types of Food That Contain Gluten?

Gluten is predominantly found in whole grains like rye, barley, triticale and oats; in wheat varieties like spelt, kamut, farro, durum; and in other products like bulgar and semolina.2 Wheat-based flours and byproducts that also contain high quantities of this protein include:3,4,5,6

...
Wheat-Based Flours

Does a Full Moon Affect Human Behavior? Articles

By Dr. Mercola

This natural phenomenon takes place once every 29.53 days, or roughly once a month. As it did in March 2018, it sometimes appears twice a month. It occurs when the moon is completely illuminated by the sun's rays as a result of the Earth being nearly directly aligned between the sun and the moon. By now, you probably know what it is: a full moon.

Urban legend suggests the full moon brings out the worst in both people and situations. If you talk to emergency room (ER) personnel, firefighters, paramedics and police officers, they very likely will share a story or two about the lunacy that occurs on nights when the sky is enlivened by a full moon.

By the way, the word lunacy and a related term lunatic, which was coined in the mid-16th century to refer to a temporary insanity in humans attributable to changes in the moon, have their origin in the Latin root luna, which means moon.

According to Scientific American, Belief in the lunar lunacy effect, or Transylvania effect, as it is sometimes called, persisted in Europe through the Middle Ages, when humans were widely reputed to transmogrify into werewolves or vampires during a full moon.1 But is it true? Does a full moon negatively affect human behavior? Lets take a closer look at the facts.

The Full Moon Has Been Said to Cause Accidents, Crimes, Suicides and More

Eric Chudler, Ph.D., a research associate professor in the department of bioengineering at the University of Washington in Seattle, has compiled research highlighting possible links between a full moon and human behavior. Below are the major categories of activities and experiences noted by Chudler that have been associated with increased activity during a full moon:2

Anxiety and depression

Animal bites

Accidents

Crime

Drug overdoses

ER visits

Hospital admissions

Suicides...

Electromagnetic Radiation Specialist Reveals the Hidden Dangers of Electric Fields Articles

By Dr. Mercola

In the featured video, Xiren, host of Know How Things Work, interviews Oram Miller, building biology environmental consultant, electromagnetic radiation specialist in Los Angeles, and director of learning and development for the Institute for Building Biology and Ecology (IBE, www.hbelc.org).

Many of Millers clients have electromagnetic sensitivities, but some simply want to have as healthy an environment as possible. In some cases, hell assess electromagnetic field (EMF) levels in a home before the client purchases the home or moves into an office space. In addition to writing about the health hazards of EMF on his website, www.createhealthyhomes.com, Miller also lectures on this topic, and has been interviewed a number of times.

He also co-written a book called Breathing Walls,1 which details design protocols to avoid and eliminate mold and chemical outgassing in new and remodeled homes.

One key focus of this EMF interview, which is typically overlooked, is the importance of measuring electric fields and not just magnetic fields. Electric fields are sort of the unknown EMF, Miller says, but can have just as detrimental an effect on your health as other more well-known EMFs on everybodys minds today.

Factors That Affect the Health of Your Home

As mentioned in this interview, a wide array of factors affect the health of your home and you. This includes factors that affect indoor air quality, such as mold, chemical outgassing, radon, asbestos, lead, natural gas, carbon monoxide and more. Then theres the EMF sources:

  1. AC electric fields at 60 Hz (the E component of EMF) from house wiring and corded appliances (especially ungrounded ones; cords that have only two prongs rather than three)
  2. AC Magnetic fields at 60 Hz (the M component of EMF) from power lines, wiring errors on house wiring, current on grounding paths, and from motors and transformers (point sources)
  3. Radio frequencies (RF) from cellphones, smart meters, Wi-Fi and Bluetooth in just about everything these days
  4. Dirty electricity from transient voltage spikes from 2 to 100 KHz...

14:32

Concerns linger in fallout of Husky fire Fluoride Action Network

(Jed Carlson / jcarlson@superiortelegram.com) Smoke from the fire at Husky Energy could be seen for miles.

More than 100 people turned out Wednesday night at Zion Lutheran Church to hear from scientists and a water protector from the Fond du Lac tribe about the potential lasting effects of a fire April 26 at Husky Energy in Superior.

Steven Sternberg, a chemical engineer with the University of Minnesota Duluth; Lorena Rios Mendoza, an associate professor of chemistry at the University of Wisconsin Superior; and Debra Topping, a water protector with the Fond du Lac Band of Chippewa, were on hand to share their perspectives and answer questions during a meeting organized by an ad hoc group of community members.

We have no idea what all the molecules are, Sternberg said during his opening statement. He said no one has every fully classified fractional asphalt molecules. He said some of the asphalt was likely vaporized and some of it didnt burn completely, creating new substances that didnt just vanish when they hit the air.

Materials in the cloud are going to be deposited on the ground, with the bigger chunks staying near the facility and smaller particles being deposited further downwind from the fire, Sternberg said.

Just because you cant see them doesnt mean theyre not there, Sternberg said. He cautioned people living downwind of the fires plume about working with the soil and eating food grown in the soil because while plants will consume the particulates, they will linger in the plants. However, he said plants can help clean the soil.

But Sternberg admitted that a lot of what people were going to hear is that they just don...

13:37

Are All Calories Equal With Regards To Disease and Obesity? PreventDisease.com

While calories from any food have the potential to increase the risk of obesity and other cardiometabolic diseases, 22 nutrition researchers agree that sugar-sweetened beverages play a unique role in chronic health problems. The disease risk increases even when the beverages are consumed within diets that do not result in weight gain.

13:08

Dietary supplementation of strawberry attenuates indices of vascular inflammation and dysfunction in diabetic db/db mice. GreenMedInfo

PMID:  Int J Cardiol. 2018 Jul 15 ;263:111-117. Epub 2018 Apr 12. PMID: 29681407 Abstract Title:  Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice. Abstract:  BACKGROUND: Cardiovascular disease is 2-4-fold more prevalent in patients with diabetes. Human studies support the cardiovascular benefits of strawberry consumption but the effects of strawberry on diabetic vasculature are unknown. We tested the hypothesis that dietary strawberry supplementation attenuates vascular inflammation and dysfunction in diabetic mice.METHODS: Seven-week-old diabetic db/db mice that consumed standard diet (db/db) or diet supplemented with 2.35% freeze-dried strawberry (db/db+SB) for ten weeks were compared to non-diabetic control mice (db/+). Indices of vascular inflammation and dysfunction were measured. Endothelial cells (ECs) were isolated from the vasculature to determine the influence of strawberry on them. The effect of metabolites of strawberry on endothelial inflammation was determined by incubating mouse aortic ECs (MAECs) with 5% serum, obtained from strawberry fed mice (metabolites serum) or standard diet fed mice (control serum)25mM glucose and 100M palmitate.RESULTS: db/db mice exhibited an increased monocyte binding to vessel, elevated blood pressure, and reduced endothelial-dependent vasorelaxation compared with db/+ mice but each defect was attenuated in db/db+SB mice. The elevation of inflammatory molecules, NOX2 and inhibitor-B kinase observed in ECs from db/db vs. db/+ mice was suppressed in db/db+SB mice. Glucose and palmitate increased endothelial inflammation in MAECs but were normalized by co-incubation with metabolites serum.CONCLUSIONS: Dietary supplementation of strawberry attenuates indices of vascular inflammation and dysfunction in diabetic db/db mice. The effect of strawberry on vasculature is endothelial-dependent and possibly mediated through their circulating metabolites. Strawberry might complement conventional therapies to improve vascular complications in diabetics.

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12:58

Hydroalcoholic extracts of C. aurantium have potential to relieve mucosal inflammation in the colon. GreenMedInfo

PMID:  Planta Med. 2018 May 4. Epub 2018 May 4. PMID: 29727864 Abstract Title:  Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis. Abstract:  Although traditionally used to improve indigestion, diarrhea, dysentery, and constipation, the therapeutic effects ofon intestinal inflammation remain unclear. The aim of this study was to evaluate the beneficial effects and to identify the active components of a hydroalcoholic extract of(HECA) on ulcerative colitis. HECA was prepared with 70% ethanol solution in water and extracted at 37C for 12h in triplicate, filtered through a sieve, and lyophilized. Phytochemical identification of HECA was performed by ultra-performance liquid chromatography-diode array detector-tandem mass spectrometry (UPLC-DAD-MS/MS). Animals were randomly assigned to one of four groups based on thetreatment conditions. Ulcerative colitis was induced by administration of 2.5% dextran sodium sulfate (DSS) in drinking water for 5d. Body weight, clinical signs, colon length, pro-inflammatory cytokine expression levels, and histopathological findings were evaluated. In UPLC-DAD-MS/MS analysis,the identified phytochemical components of HECA included four alkaloids, seven coumarins, 18 flavonoids, two lignans, two phenolics, and 10 terpenoids. HECA markedly protected against body weight loss and colon shortening. In pathological examination, HECA alleviated DSS-related mucosal inflammatorylesions in the colon. Moreover, HECA markedly reduced the expression levels of interleukin-6, interferon-, tumor necrosis factor-, and monocyte chemotactic protein-1 in colonic inflammation. Taken together, HECA has potential to relieve mucosal inflammation in the colon, suggesting that the putative active ingredients are responsible for the anti-ulcerative effects.

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12:49

Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. GreenMedInfo

PMID:  Oncol Rep. 2018 May 8. Epub 2018 May 8. PMID: 29749527 Abstract Title:  Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Abstract:  Bladder cancer (BC) is the most common malignant disease. The developing of economically sustainable and available agents for the treatment of BC is required. Purple sweet potato anthocyanin (PSPA) has been shown to have antitumor abilities. The present study aimed to evaluate the potential role of PSPA in BC treatment. CCK-8 assay was used to assess the viability of BC cells. Flow cytometry assays were performed to evaluate the mitochondrial membrane potential (MMP), cell apoptosis and cell-cycle distribution. Real-time PCR (RT-PCR) and western blot analysis were performed to determine the expression of the target genes. The results of this study revealed that PSPA reduced the viability of BC in a dose-dependent manner. The MMP collapse was aggravated by the PSPA treatment. The apoptosis rate was higher in the PSPA groups than that in the control group. The expression of the pro-apoptosis genes, including cleaved caspase-3, Fas, Fasl, Bcl-2-associated X proteins (Bax) and anti-apoptotic gene (Bcl-2) was induced and decreased by PSPA, respectively. The cell-cycle progression was suppressed by the presence of PSPA. The activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt (PI3K/Akt) signaling pathway was suppressed by PSPA treatment during BC treatment. The PI3K/Akt signaling was closely related to the antitumor effect of PSPA in BC. The present study provided evidence regarding the treatment of BC and enhanced the understanding of the potential role that PSPA plays in cancer prevention.

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12:42

Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3. GreenMedInfo

PMID:  Acta Pharmacol Sin. 2018 May 16. Epub 2018 May 16. PMID: 29769742 Abstract Title:  Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3. Abstract:  Modified citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G/M phase arrest with the decrease of Cyclin B1 and phosphorylated Cdc2. Caspase-3 was also activated, leading to the cleavage of Caspase-3 and PARP. We further explored the possible molecular mechanisms upon MCP treatment in UBC cells. Reduction of galectin-3 was observed and followed with the inactivation of Akt signaling pathway. Of note, galectin-3 knockdown by RNA interference recapitulated the MCP-mediated anti-proliferation, cell cycle arrest and apoptosis. Moreover, oral administration of MCP to the T24 xenograft-bearing nude mice inhibited the tumor growth significantly (P

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12:37

The studies included in this review and meta-analysis showed an inverse association between citrus fruit intake and oral cancer. GreenMedInfo

PMID:  Pharmacol Res. 2018 May 10. Epub 2018 May 10. PMID: 29753688 Abstract Title:  Citrus fruits intake and oral cancer risk: a systematic review and meta-analysis. Abstract:  OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.DESIGN: Systematic review and meta-analysis.DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm.STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.DATA EXTRACTION: Three reviewers independently performed the extraction of data from studies included.RESULTS: Seventeen studies met our inclusion criteria and were included in the final review. Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50% reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95% CI 0.43-0.59).CONCLUSION: The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer.

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12:29

Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers. GreenMedInfo

PMID:  J Sci Food Agric. 2018 May ;98(7):2777-2786. Epub 2017 Nov 28. PMID: 29124773 Abstract Title:  Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers in healthy humans. Abstract:  BACKGROUND: Alcoholic fermentation of fruits has generated novel products with high concentrations of bioactive compounds and moderate alcohol content. The aim of this study was to evaluate the potential effect on cardiovascular risk factors of the regular consumption by healthy humans of a beverage obtained by alcoholic fermentation and pasteurization of orange juice.RESULTS: Thirty healthy volunteers were enrolled in a randomized controlled study. The experimental group (n=15) drank 500mL orange beverage (OB) per day for 2weeks (intervention phase), followed by a 3-week washout phase. Blood samples were collected at baseline (E-T0) and at the end of the intervention (E-T1) and washout (E-T2) phases. Controls (n=15) did not consume OB during a 2-weekperiod. OB intake significantly increased oxygen radical absorbance capacity (43.9%) and reduced uric acid (-8.9%), catalase (CAT) (-23.2%), thiobarbituric acid reactive substances (TBARS) (-30.2%) and C-reactive protein (-2.1%) (E-T1 vs. E-T0). These effects may represent longer-term benefits, given the decreased uric acid (-8.9%), CAT (-34.6%), TBARS (-48.4%) and oxidized low-density lipoprotein (-23.9%) values recorded after the washout phase (E-T2 vs. E-T0).CONCLUSION: The regular consumption of OB improved antioxidant status and decreased inflammation state, lipid peroxidation and uric acid levels. Thus OB may protect the cardiovascular system in healthy humans and be considered a novel functional beverage. 2017 Society of Chemical Industry.

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12:21

Yogurt consumption improved postprandial metabolism and biomarkers of metabolic endotoxemia in healthy premenopausal women. GreenMedInfo

PMID:  J Nutr. 2018 May 15. Epub 2018 May 15. PMID: 29767743 Abstract Title:  Premeal Low-Fat Yogurt Consumption Reduces Postprandial Inflammation and Markers of Endotoxin Exposure in Healthy Premenopausal Women in a Randomized Controlled Trial. Abstract:  Background: Metabolic endotoxemia is associated with obesity and contributes to postprandial inflammation.Objective: We aimed to determine if low-fat yogurt consumption prevents postprandial inflammation and dysmetabolism in healthy women by inhibiting biomarkers of metabolic endotoxemia.Methods: Premenopausal women defined as obese and nonobese [body mass index (BMI, in kg/m2) 30-40 and 18.5-27, respectively, n = 120] were randomly assigned to consume 339 g of low-fat yogurt (YN, yogurt nonobese; YO, yogurt obese) or 324 g of soy pudding (CN, control nonobese; CO, control obese) for 9 wk (n = 30/group). The intervention foods each supplied 330 kcal with 3 g fat, 66 g carbohydrate, and 4-6 g protein. At weeks 0 and 9, participants ingested 226 g of yogurt or 216 g of soy pudding before a meal providing 56-60 g fat, 82 g carbohydrate, and 28-30 g protein. Plasma soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP), LPS activity, interleukin-6 (IL-6), glucose, triglyceride, andinsulin were measured hourly for 4 h to assess differences in postprandial responses between groups by 2-factor ANOVA.Results: Premeal yogurt consumption prevented the postprandial decrease in sCD14 net incremental area under the curve (net iAUC) by 72% in obese individuals at week 0 (P = 0.0323). YN and YO had 40% lower net iAUC of LBP-to-sCD14 ratio and plasma IL-6 concentration than CN and CO, respectively (P 

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11:58

Manuka honey exhibited a marked potential to protect DNA of whole blood cells from oxidative damage induced by hydrogen peroxide. GreenMedInfo

PMID:  Food Chem Toxicol. 2018 May 12. Epub 2018 May 12. PMID: 29763681 Abstract Title:  Manuka honey attenuates oxidative damage induced by HOin human whole blood in vitro. Abstract:  Manuka honey has been widely researched regarding its biological properties, in particular its antimicrobial and antioxidant capacities. We tested the genotoxic and genoprotective properties of Manuka honey, ranging from 25-1000g/mL, by performing an in vitro comet assay after exposure to human whole blood. No genotoxic effect on whole blood cells was observed within the tested concentration range (p=0.154). Then, the antigenotoxic potency of Manuka honey against oxidative DNA damage to whole blood cells was assessed. Prior to Manuka honey treatment a modest decrease of HO-induced DNA damage was detected in cells, with no statistical significance (p=0.087). Post-treatment, Manuka honey displayed a stronger potential to attenuate damaged cells at all tested concentrations, with a statistical significant difference (p

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11:50

Berbamine has anti-hypercholesterolemic and hepatoprotective effects. GreenMedInfo

PMID:  Iran J Pharm Res. 2018 ;17(1):292-306. PMID: 29755560 Abstract Title:  Anti-hypercholesterolemic Effect of Berbamine Isolated fromin Hypercholesterolemic Zebrafish Induced by High-Cholesterol Diet. Abstract:  The anti-hypercholesterolemic effect of berbamine (BBM) isolated from(RC) was investigated in hypercholesterolemic zebrafish model induced by high-cholesterol (HC) diet. Zebrafish embryo assay revealed no significant difference in morphology and cell death with the treatment of BBM less than 20g/mL. In zebrafish larvae, the fluorescently labeled cholesterol in caudal artery was reduced dose-dependently after BBM treatment. For adult zebrafish, administration of 0.2% BBM exhibited a significant decrease in plasma total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-c) levels by 37%, 38% and 28%, respectively, along with a fall in lipid content in liver. Further investigation suggested that the mRNA expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and microsomal triglyceride transfer protein (MTP) in liver were down-regulated and the transcription levels of liver gene low-density lipoprotein receptor (LDLR) and cytochrome P450 polypeptide 1a of subfamily A of family 7 (CYP7A1a) were significantly up-regulated with BBM treatment. Histological study showed that BBM can alleviate hepatic steatosis induced by HC diet. These data suggested that BBM has anti-hypercholesterolemic and hepatoprotective effects. The mechanism probably related to the up-regulation of cholesterol transport and bile acid synthesis as well as inhibition of cholesterol synthesis and lipoprotein assembly or secretion.

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11:32

Berberine might be a promising new strategy for the treatment of adenomyosis. GreenMedInfo

PMID:  J Pharmacol Sci. 2017 Dec 8. Epub 2017 Dec 8. PMID: 29752208 Abstract Title:  Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: Imply the possible treatment of adenomyosis. Abstract:  Adenomyosis is a common chronic gynecological disorder with some tumor-like properties, including aberrant proliferation, invasion and migration. Berberine (BBR) is an isoquinoline derivative alkaloid with diverse pharmacological activities for the treatment of a wide variety of diseases. However, the effect of BBR on adenomyosis has not been understood. This study was to evaluate the potential therapeutic effect of BBR on ectopic endometrial stromal cells (EESCs) isolated from patients with adenomyosis. Our data showed that BBR significantly inhibited the proliferation and viability of eutopic endometrial stromal cells (EuESCs) and EESCs, while slightly affected the growth of normal endometrial stromal cells (NESCs). BBR markedly exhibited a growth inhibitory effect on EESCs by triggering apoptosis and cell cycle arrest, and alleviating the expression of inflammatory invasive phenotypes (IL-6, IL-8, TGF-, EGF, VEGF, and MMP2). The alleviation of inflammatory invasive phenotypes partly involved nuclear translocation of NFB/p65 and stat3 activation. Taken together, BBR markedly inhibits the growth of EESCs and might be a promising new strategy for the treatment of adenomyosis.

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11:26

Berberine: Pathways to protect neurons. GreenMedInfo

PMID:  Phytother Res. 2018 May 6. Epub 2018 May 6. PMID: 29732634 Abstract Title:  Berberine: Pathways to protect neurons. Abstract:  Berberine, an isoquinoline alkaloid, is demonstrated to have a variety of pharmacologic effects. Widely used as nonprescription drug for diarrhea, berberine has also broadened its applications in therapies of cardiovascular diseases, diabetes mellitus, tumor, and so forth. However, researches about berberine's protective effects on nervous system are still so insufficient that clinical uses cannot popularize and underlying molecules mechanisms are confused and incomplete. Well-known pathways such as Pl3K/Akt/Bcl-2 pathway, Nrf2/HO-1 pathway, and MAPK signaling pathway help berberine to protect neurons through antiapoptotic, antioxidative, and anti-inflammatory activities. New hypotheses have been raised consistently to explore more possible ways of berberine preventing nerves from injuries as attention on its neuroprotective properties is increasing. Therefore, this review is trying to analyze these mechanisms, which actually play roles in neuronal disease models such as brain ischemia, Alzheimer's disease, and experimental autoimmune encephalomyelitis. Much more understanding about how berberine mediates these pathways provides novel insights into the clinical treatment of neurological disorders.

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11:18

Curcumin has an ameliorative effect on chlorpyrifos-induced biochemical changes in Cyprinus carpio. GreenMedInfo

PMID:  Ecotoxicol Environ Saf. 2018 Apr 30 ;151:49-54. Epub 2018 Jan 3. PMID: 29306070 Abstract Title:  Chlorpyrifos-induced biochemical changes in Cyprinus carpio: Ameliorative effect of curcumin. Abstract:  The aim of this study was to determine protective effects of curcumin on some haematological values and oxidant/antioxidant status in Cyprinus carpio exposed to chlorpyrifos. The fish were exposed to two sublethal concentrations of chlorpyrifos (0.040 and 0.080mgL), and curcumin (100mg per kg of fish weight) was simultaneously administered for 14 days. Blood and tissue (liver, kidney, and gill) samples were collected at the end of the experiment and analysed to determine the haematological profile (red blood cell count, white blood cell count, haemoglobin concentration, and haematocrit level) and oxidant/antioxidant status (malondialdehyde level and superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase activities) of the fish. There was a significant decrease in the red blood cell count, the haemoglobin concentration, and the haematocrit level and a increase in the white blood cell count of CPF-treated fish. The results revealed a significant increase in the malondialdehyde levels of the groups that were exposed to CPF. Conversely, the MDA levels were significantly decreased by curcumin. Also, CPF exposure caused a significant increase in the superoxide dismutase and glutathione-S-transferase activities and a significant decrease in the catalase and glutathione peroxidase activities. However, curcumin reversed the superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase activities. In conclusion, this study demonstrated that CPF had a negative effect on the haematological values and the oxidant/antioxidant status of the fish. The simultaneous administration of curcumin was neutralised CPF-induced toxicity.

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11:14

Chronic exposure to chlorpyrifos is associated with higher sleep apnea index and modifies respiratory patterns in sleeping juvenile and adult rats. GreenMedInfo

PMID:  PLoS One. 2018 ;13(1):e0191237. Epub 2018 Jan 22. PMID: 29357379 Abstract Title:  Impact of chronic exposure to the pesticide chlorpyrifos on respiratory parameters and sleep apnea in juvenile and adult rats. Abstract:  The widely used organophosphorus pesticide chlorpyrifos (CPF) is often detected in food. CPF inhibits acetylcholinesterase and can modify muscle contractility and respiratory patterns. We studied the effects of chronic exposure to CPF on respiratory parameters and diaphragm contractility in 21- and 60-days old rats. Pregnant rats were exposed to oral CPF (1 or 5 mg/kg/day: CPF-1 or CPF-5 groups vs vehicle: controls) from gestation onset up to weaning of the pups that were individually gavaged (CPF or vehicle) thereafter. Two developmental time points were studied: weaning (day 21) and adulthood (day 60). Whole-body plethysmography was used to score breathing patterns and apnea index during sleep. Then, diaphragm strips were dissected for the assessment of contractility and acetylcholinesterase activity. Results showed that the sleep apnea index was higher in CPF-exposed rats than in controls. In adult rats, the expiratory time and tidal volume werehigher in CPF-exposed animals than in controls. At both ages, the diaphragm's amplitude of contraction and fatigability index were higher in the CPF-5 group, due to lower acetylcholinesterase activity. We conclude that chronic exposure to CPF is associated with higher sleep apnea index and diaphragm contractility, and modifies respiratory patterns in sleeping juvenile and adult rats.

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11:02

The available data provide novel evidence that deregulation of testicular miR-146a-5p/Mta3 cascade mediates the dysfunction caused by BPA exposure. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2018 May 9. Epub 2018 May 9. PMID: 29746863 Abstract Title:  Bisphenol A-elicited miR-146a-5p impairs murine testicular steroidogenesis through negative regulation of Mta3 signaling. Abstract:  The epigenetic effects on expression of non-coding RNAs (e.g. microRNAs) of environmental toxin bisphenol A (BPA) have extended our understanding of the etiology of human reproductive disorders including hypospermatogenesis and androgen deficiency. BPA-induced miR-146a-5p is a potent regulator of endocrine and immune homeostasis, but its role in testis remain unexplored. We show here that in murine testis, miR-146a-5p was exclusively expressed in interstitial Leydig cells (LCs). This expression was significantly induced by BPA exposure. Consequently, the elevated miR-146a-5p exacerbated the deleterious effects of BPA on testicular steroidogenesis. Mechanistically, miR-146a-5p repressed the expression of Mta3, a pivotal chromatin remodeling transcription factor recently involved in controlling the steroidogenic activity, via directly targeting its 3'UTR. This repression thereafter rendered LCs more sensitive to BPA-elicited inhibitory effects. Conversely, ectopic expression of hMTA3 successfully rescued miR-146a-5p-elicited inhibitory effects on testicular steroidogenesis in BPA-challenged LCs. Taken together, the available data provide novel evidence that deregulation of testicular miR-146a-5p/Mta3 cascade mediates, at least in part, the steroidogenic dysfunction caused by BPA exposure.

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10:57

Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. GreenMedInfo

PMID:  Horm Behav. 2018 May 12. Epub 2018 May 12. PMID: 29763587 Abstract Title:  Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. Abstract:  Fetal exposure to endocrine disrupting chemicals (EDCs) has been associated with adverse neurobehavioral outcomes across the lifespan and can persist across multiple generations of offspring. However, the underlying mechanisms driving these changes are not well understood. We investigated the molecular perturbations associated with EDC-induced behavioral changes in first (F1) and second (F2) filial generations, using the model EDC bisphenol A (BPA). C57BL/6J dams were exposed to BPA from preconception until lactation through the diet at doses (10g/kg bw/d-lower dose or 10mg/kg bw/d-upper dose) representative of human exposure levels. As adults, F1 male offspring exhibited increased depressive-like behavior, measured by the forced swim test, while females were unaffected. These behavioral changes were limited to the F1 generation andwere not associated with altered maternal care. Transcriptome analysis by RNA-sequencing in F1 control and upper dose BPA-exposed adult male hippocampus revealed neurotransmitter systems as major pathways disrupted by developmental BPA exposure. High performance liquid chromatography demonstrated amale-specific reduction in hippocampal serotonin. Administration of the selective serotonin reuptake inhibitor fluoxetine (20mg/kg bw) rescued the depressive-like phenotype in males exposed to lower, but not upper, dose BPA, suggesting distinct mechanisms of action for each exposure dose. Finally, high resolution mass spectrometry revealed reduced circulating levels of the neuroactive steroid dehydroepiandrosterone in BPA-exposed males, suggesting another potential mechanism underlying the depressive-like phenotype. Thus, behavioral changes associated with early life BPA exposure may be mediated by sex-specific disruptions in the serotonergic system and/or sex steroid biogenesis in male offspring.

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10:46

Caffeic acid phenethyl ester could be a promising agent against nasopharyngeal carcinoma. GreenMedInfo

PMID:  Int J Mol Sci. 2018 May 8 ;19(5). Epub 2018 May 8. PMID: 29738439 Abstract Title:  Caffeic Acid Phenethyl Ester Induces-myc Downstream Regulated Gene 1 to Inhibit Cell Proliferation and Invasion of Human Nasopharyngeal Cancer Cells. Abstract:  Caffeic acid phenethyl ester (CAPE), a bioactive component extracted from propolis, is widely studied due to its anti-cancer effect. Nasopharyngeal carcinoma (NPC) is distinct from other head and neck carcinomas and has a high risk of distant metastases.-myc downstream regulated gene 1 (NDRG1) is demonstrated as a tumor suppressor gene in several cancers. Our result showed that CAPE treatment could repress NPC cell growth, through induction of S phase cell cycle arrest, and invasion. CAPE treatment stimulated NDRG1 expression in NPC cells. NDRG1 knockdown increased NPC cell proliferation and invasion and rendered NPC cells less responsive to CAPE growth-inhibiting effect, indicating CAPE repressed NPC cell growth partly through NDRG1indcution. CAPE treatment increased phosphorylation of ERK, JNK, and p38 in a dose- and time-dependent manner. Pre-treatments by inhibitors of ERK (PD0325901), JNK (SP600125), or p38 (SB201290), respectively, all could partly inhibit the CAPE effect on NDRG1 induction in NPC cells. Further, STAT3 activity was also repressed by CAPE in NPC cells. In summary, CAPE attenuates NPC cell proliferation and invasion by upregulating NDRG1 expression via MAPK pathway and by inhibiting phosphorylation of STAT3. Considering the poor prognosis of NPC patients with metastasis, CAPE could be a promising agent against NPC.

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10:32

Anti-glioma effects of Caffeic acid phenethyl ester and Dasatinib combination therapy in an in vivo glioma model. GreenMedInfo

PMID:  Anticancer Agents Med Chem. 2018 May 15. Epub 2018 May 15. PMID: 29766825 Abstract Title:  Anti-glioma effects of Caffeic acid phenethyl ester and Dasatinib combination therapy in an in vivo rat glioma model. Abstract:  BACKGROUND: Caffeic acid phenethyl ester and Dasatinib in combination, when used in congruous proportions and durations, present an antitumor potential for glioma in vitro, suggesting a high therapeutic potential for glioma treatment.OBJECTIVE: In the present study, we addressed the question whether CAPE and Dasatinib target multiple pathways involved in tumor growth, proliferation and development on an in vivo rat model of glioma.METHODS: Expression analysis of proteins thought to be mediating proliferation, cell motility, angiogenesis, and invasion was carried out to delineate the antineoplastic action of CAPE and Dasatinib.RESULTS: CAPE and Dasatinib modulates the expression of proteins having potential interactive crosstalk with major oncogenic pathways involved in glioma progression. Our results showed that combination treatment modulates the expression of p53 in group co-administered with CAPE and Dasatinib after glioma induction in comparison to group induced with glioma only. EGFR and PCNA expression were significantly altered in the co-treated group in comparison to the glioma-induced group. The effects of CAPE and Dasatinib treatment were further evaluated on AKT pathway by Western blot analysis, the co-treated group showed a significant reduction in expression of AKT. The histopathological analysis further backed the antiproliferative and anti invasive effects of CAPE and Dasatinib.CONCLUSION: This study in totality suggests that the combinational therapy remarkably reduces the proliferation of glioma cells in vivo, suggesting that CAPE and Dasatinib therapy could be exploited for the management of gliomas without showing drug-related resistances and side effects, suggesting a high therapeutic potential of the therapy in glioma.

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09:29

Inhibition of aortic calcification by policosanol in dyslipidemic rabbits is enhanced by pentoxifylline. GreenMedInfo

PMID:  J Cardiovasc Pharmacol Ther. 2018 Jan 1:1074248418775377. Epub 2018 Jan 1. PMID: 29742924 Abstract Title:  Inhibition of Aortic Calcification by Policosanol in Dyslipidemic Rabbits Is Enhanced by Pentoxifylline: Potential Role of PCSK9. Abstract:  Policosanol (POL) is a hypocholesterolemic drug of natural origin and has been shown to reduce circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in healthy participants. Recently, we have reported that POL can attenuate aortic calcification in diabetic dyslipidemic rats; however, the underlying mechanism is not fully elucidated. We aimed to investigate the effect of POL on aortic calcification and whether PCSK9 has a contributory role and also to examine whether the combination of POL with pentoxifylline (PTX) as anti-tumor necrosis factor would offer additional benefits. Thirty adult male New Zealand rabbits weighing 1.5 to 2 kg were randomly assigned to 5 groups. One group received standard chow diet and served as normal control group (NC). The other 4 groups received 0.5% wt/wt cholesterol-rich diet for 12 weeks and concurrentlytreated with placebo, POL, PTX, or a combination of POL and PTX. Sera samples and aortic tissue were collected for biochemical measurements and histological assessment. Rabbits fed a cholesterol-rich diet demonstrated dyslipidemia, increased inflammatory state, and elevated serum levels of PCSK9, compared to the NC group. Aortic calcification was evident in dyslipidemic rabbits, represented by increased calcium deposition and osteopontin expression in aortic tissue, along with elevated serum levels of alkaline phosphatase and osteocalcin. Dyslipidemic rabbits showed a significant upregulationof wingless-type MMTV integration site family 3A and bone morphogenetic protein 2 genes in their aortic tissue. Policosanol significantly reduced circulating PCSK9 levels, suppressed calcification markers, and attenuated aortic calcification. Combination of POL with PTX alleviated aortic calcification to a greater extent than either monotherapy, which may be attributed to further suppression of PCSK9 and calcification markers. These findings suggested that POL exerted anticalcifying effect partly via inhibition of PCSK9. Combination of POL and PTX offered additional benefits and might represent a promising therapeutic option for aortic calcification.

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09:07

Blood pressure lowering effect of Cuban policosanol is accompanied by improvement of hepatic inflammation. GreenMedInfo

PMID:  Molecules. 2018 May 3 ;23(5). Epub 2018 May 3. PMID: 29751583 Abstract Title:  Blood Pressure Lowering Effect of Cuban Policosanol is Accompanied by Improvement of Hepatic Inflammation, Lipoprotein Profile, and HDL Quality in Spontaneously Hypertensive Rats. Abstract:  We investigated the antihypertensive effect of policosanol on spontaneously hypertensive rats (SHR). For this, we analyzed blood pressure, blood lipid, and lipoprotein properties in male SHR after consumption of Cuban policosanol (PCO). The experimental groups were as follows: normotensive Wistar Kyoto (WKY) control, SHR group fed normal diet (ND), SHR group fed 20 mg of PCO, SHR group fed 100 mg of PCO, and SHR group fed 200 mg of PCO per kg of body weight. After eight weeks, the SHR control group showed gradual increases up to 21% in systolic blood pressure (SBP) and diastolic blood pressure (DBP) compared with values at week 0. However, policosanol consumption had a dose-dependent reduction effect on SBP and also reduced DBP up to 17% in a dose-dependent manner. Heart rate (HR) bpm increased by six percent in the SHR control, whereas the 20 mg, 100 mg, and 200 mg of policosanol groups showed a reduction of 36%, 28%, and 34% respectively. Although serum total cholesterol (TC) level of SHR was not affected by policosanol consumption (7080 mg/dL), serum triglyceride (TG) level significantly decreased in the SHR + 200 mg of PCO group. Serum high-density lipoprotein cholesterol (HDL-C) level was also significantly elevated by policosanol consumption. The % HDL-C/TC ratio was elevated in the policosanol group up to 6770%, whereas the SHR control group showed a ratio of 58%. Serum cholesteryl ester transfer protein (CETP) activity was reduced by policosanol in a dose-dependent manner. Although the serum glutamate oxaloacetate transaminase (GOT)/ glutamate pyruvate transaminase (GPT) were similar across all groups, policosanol consumption caused reduction of reactive oxygen species (ROS) levels in hepatic tissue. The SHR control group showed a 2.1-fold higher serum C-reactive protein (CRP) level than the WKY group, whereas the CRP level decreased in the SHR + 200 mg of PCO group (up to 45%) than SHR control group. Aldosterone level was reduced in the policosanol group (up to 34%) in a dose-dependent manner compared to the control. In conclusion, eight weeks of policosanol consumption in SHR resulted in remarkable reduction of blood pressure, serum aldosterone, and serum TG levels along with the elevation of HDL-Cand improvement of hepatic inflammation.

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08:57

Policosanol consumption simultaneously reduces peripheral blood pressure as well as aortic blood pressure. GreenMedInfo

PMID:  Front Physiol. 2018 ;9:412. Epub 2018 Apr 24. PMID: 29765328 Abstract Title:  Long-Term Consumption of Cuban Policosanol Lowers Central and Brachial Blood Pressure and Improves Lipid Profile With Enhancement of Lipoprotein Properties in Healthy Korean Participants. Abstract:  Metabolic syndrome is closely associated with higher risk of hypertension, cardiovascular disease (CVD), diabetes and stroke. The aim of the present study was to investigate the long-term effects of policosanol supplementation on blood pressure (BP) and the lipid profile in healthy Korean participants with pre-hypertension (systolic 120-139 mmHg, diastolic 85-89 mmHg). This randomized, double-blinded, and placebo-controlled trial included 84 healthy participants who were randomly assigned to three groups receiving 10 mg of policosanol, 20 mg of policosanol, or placebo for 24 weeks. The BP, lipid profile, and anthropometric factors were measured pre- and post-intervention and then compared. Based on an average of three measurements of brachial BP, the policosanol 20 mg group showed the most significant reduction in average systolic BP (SBP) from 138 12 mmHg at week 0 to 126 13 mmHg at week 24 (

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08:27

Liquorice extract scavenged free radical in a dose-response manner in vitro. GreenMedInfo

PMID:  Meat Sci. 2015 Jul ;105:38-45. Epub 2015 Mar 6. PMID: 25771136 Abstract Title:  Antioxidant effects of liquorice (Glycyrrhiza uralensis) extract during aging of longissimus thoracis muscle in Tan sheep. Abstract:  The study was conducted to investigate the potential of liquorice extract (LE) from Glycyrrhiza uralensis as a dietary supplement for sheep to improve antioxidant capacity of meat. Fifty Tan sheep were randomly allocated to five groups with LE supplementation at levels of 0, 1000, 2000, 3000 and 4000 mg/kg feed. After 120 days, the longissimus thoracis muscle was sampled and conditioned for 0, 2, 4, 6 and 8 days at 4C. The results revealed that LE scavenged free radical in a dose-response manner in vitro. Supplementation with LE in animal diet increased (P

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08:23

Glycyrrhizae radix is relatively safe and has protective effects against the damage caused by both heat-stress and oxidative stress. GreenMedInfo

PMID:  J Ethnopharmacol. 2016 Jan 11 ;177:101-10. Epub 2015 Nov 25. PMID: 26626487 Abstract Title:  Beneficial effects of Glycyrrhizae radix extract in preventing oxidative damage and extending the lifespan of Caenorhabditis elegans. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Glycyrrhizae radix (GR) is a medicinal herb extensively used in traditional Chinese medicine. This study aimed to evaluate the pharmacological effect of GR and the possible mechanisms of GR, to provide a pharmacological basis in traditional medicine.MATERIALS AND METHODS: In the present study, C. elegans (L1-larvae to young adults) was exposed to 0.12-0.24 g/mL of GR in 12-well sterile tissue culture plates at 20C in the presence of food. Lethality, growth, lifespan, reproduction, locomotion, metabolism, intestinal autofluorescence, and reactive oxygen species (ROS) production assays were performed to investigate the possible safety profile and beneficial effects of GR in these nematodes. We found that the lifespan of nematodes exposed to 0.18-0.24 g/mL of GR was extended. We then determined the mechanism of the longevity effect of GR using quantitative reverse transcription PCR and oxidative stress resistance assays induced by heat and paraquat.RESULTS: Prolonged exposure to 0.12-0.24 g/mL of GR did not induce lethality, alter body length, morphology or metabolism, affect brood size, locomotion, the development of D-type GABAergic motor neurons, or induce significant induction of intestinal autofluorescence and intestinal ROS production. In C. elegans, pretreatment with GR suppressed the damage due to heat-stress or oxidative stress induced by paraquat, a ROS generator, on lifespan, and inhibited the induction of intestinal ROS production induced by paraquat. Moreover, prolonged exposure to GR extended lifespan, increased locomotion and decreased intestinal ROS production in adult day-12 nematodes. Furthermore, prolonged exposure to GR significantly altered the expression patterns of genes encoding the insulin-like signaling pathway which had a key role in longevity control. Mutation of daf-16 gene encoding the FOXO transcription factor significantly decreased lifespan, suppressed locomotion, and increased intestinal ROS production in GR exposed adult nematodes.CONCLUSIONS: GR is relatively safe and has protective effects against the damage caused by both heat-stress and oxidative stress at the examined concentrations. Furthermore, GR is capable of extending the lifespan of nematodes, and the insulin-like signaling pathway may play a crucial role in regulating the lifespan-extending effects of GR.

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08:09

Chlorpyrifos induced cytotoxicity may be explained by NF-B activated inflammatory cascade. GreenMedInfo

PMID:  Environ Sci Pollut Res Int. 2018 Apr ;25(12):12072-12082. Epub 2018 Feb 16. PMID: 29453720 Abstract Title:  Cytotoxic effect of chlorpyrifos is associated with activation of Nrf-2/HO-1 system and inflammatory response in tongue of male Wistar rats. Abstract:  Repeated administration of chlorpyrifos (CPF), an organophosphate pesticide, can increase the risk of oral cytotoxicity. The current study was designed to assess the mechanism by which CPF mediates its cytotoxic effect on lingual mucosa of rats. Twenty-four male Wistar rats were used in the present study and divided into three groups: group I: healthy rats (negative control), group II: rats treated with CPF 1/40 LD50 (3.375 mg/kg, orally/daily) for 28 days, group III: rats treated with CPF 1/10 LD50 (13.5 mg/kg, orally/daily) for 28 days. At the end of the experiment, all rats were sacrificed by cervical dislocation under ketamine anesthesia. Tongue samples were dissected out at their base for detection of heme oxygenase-1 (HO-1) and nuclear erythroid 2-related factor 2 (Nrf-2) by western blotting and histopathological and electron microscopic studies. Immunostaining was used to determine cleaved caspase 3 and the nuclear factor kappa B (NF-B) localization. Structural and ultrastructural examination of treated lingual mucosa with CPF demonstrated degenerative changes that involved both the dorsal and ventral surfaces of the tongue as well as the lingual glands. CPF-treated rats demonstrated a significant increase in the levels of pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF-) in addition to a significant dose-dependent activation of NF-B and cleaved caspase 3. Furthermore, CPF activated HO-1 and Nrf-2 pathway in a dose-dependent manner. In conclusion, this data suggests that the CPF-induced cytotoxicity may be explained by NF-B activated inflammatory cascade. In addition, CPF triggers an adaptive activation of Nrf-2/HO-1 pathway.

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08:02

Caffeic acid phenethyl ester prevented the neurodegenerations in brain tissue in chlorpyrifos induced Parkinson's disease. GreenMedInfo

PMID:  Pestic Biochem Physiol. 2018 Jan ;144:36-41. Epub 2017 Nov 10. PMID: 29463406 Abstract Title:  Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry. Abstract:  INTRODUCTION: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on Paraoxonase (PON1) activity, and levels of lipid profile, total sialic acid (TSA), total antioxidant capacity (TAC) and total oxidant capacity (TOC) in the plasma and brain tissue of mice with chlorpyrifos-ethyl (CPF)-induced Parkinson.MATERIAL AND METHOD: In the study, 35 male Swiss albino mice were divided into 5 groups including equal number of mice as follows; intraperitoneal injection of saline for mice in control (C) group, subcutaneous injection of 80mg/kg CPF for CPF group, intraperitoneal injection of 10mol/kg CAPE for CAPE group, subcutaneous injection of 80mg/kg CPF and intraperitoneal injection of 10mol/kg CAPE for CPF+CAPE group and intraperitoneal injection of 10% ethanol diluted in physiological saline solution for 21days for ethanol (E) group. All the mice were fed with normal feed and tap water ad libitum. At the end of the study, PON1 activity, lipid profile (except for brain), and TSA, TAC and TOC levels in the plasma and brain tissue were analyzed. Tissue samples of brain substantia nigra were evaluated histopathologically.RESULTS: Levels of plasma TAC, high density lipoprotein (HDL) and PON1 activity were statistically lower in CPF group than the other groups (P

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07:58

Survival Medicine Hour: Ticks, Volcanoes, Special Guests Doom and Bloom (TM)

Survival Medicine Hour: Ticks, Volcanoes, Special Guests

SURVIVAL MEDICINE HOUR PODCAST Can you prepare for a day at the beach? Can you prepare for an asteroid strike? Well, preparing for volcanic eruptions is in the middle, actually closer to an asteroid strike that anyone would like. Joe Alton MD and Amy Alton ARNP discuss what can and cant be done to prepare []

07:49

These results provide new understanding of the mechanisms contributing to the harmful effects of chlorpyrifos. GreenMedInfo

PMID:  Toxicology. 2018 Apr 14 ;402-403:17-27. Epub 2018 Apr 14. PMID: 29665406 Abstract Title:  SN56 neuronal cell death after 24h and 14days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3 enzyme, -amyloid and tau protein levels. Abstract:  Chlorpyrifos (CPF) is an organophosphate insecticide described to induce cognitive disorders, both after acute and repeated administration. However, the mechanisms through which it induces these effects are unknown. CPF has been reported to produce basal forebrain cholinergic neuronal cell death, involved on learning and memory regulation, which could be the cause of such cognitive disorders. Neuronal cell death was partially mediated by oxidative stress generation, P75and-nAChRs gene expression alteration triggered through acetylcholinesterase (AChE) variants disruption, suggesting other mechanisms are involved. In this regard, CPF induces A and tau proteins production and activation of GSK3 enzyme and alters glutamatergic transmission, which have been related with basal forebrain cholinergic neuronal cell death and development of cognitive disorders. According to these data, we hypothesized that CPF induces basal forebrain cholinergic neuronal cell death through induction of A and tau proteins production, activation of GSK-3 enzyme and disruption of glutamatergic transmission. We evaluated this hypothesis in septal SN56 basal forebrain cholinergic neurons, after 24h and 14days CPF exposure. This study shows that CPF increases glutamate levels, upregulates GSK-3 gene expression, and increases the production of A and phosphorylated tau proteins and all these effects reduced cell viability. CPF increases glutaminase activity and upregulates the VGLUT1 gene expression, which could mediate the disruption of glutamatergic transmission. Our present results provide new understanding of the mechanisms contributing to the harmful effects of CPF, and its possible relevance in the pathogenesis of neurodegenerative diseases.

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06:55

Guarana leads to an increase in energetic metabolism and stimulates mitochondrial biogenesis. GreenMedInfo

PMID:  Nutrients. 2018 Jan 31 ;10(2). Epub 2018 Jan 31. PMID: 29385074 Abstract Title:  Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet. Abstract:  The aim of this study was to evaluate the effects of guarana on mitochondrial biogenesis in a high-fat diet (HFD)-fed mice. C57BL6J mice were divided in two groups: high-fat diet HFD and high-fat diet + guarana (HFD-GUA). Both groups received HFD and water ad libitum and the HFD-GUA group also received a daily gavage of guarana (1 g/kg weight). Body weight and food intake was measured weekly. Glycemic, triglyceride, and cholesterol levels were determined. VO and energy expenditure (EE) were determined by indirect calorimetry. Gene expression was evaluated by real-time PCR and protein content by western blotting. The HFD-GUA group presented lower body weight, subcutaneous, retroperitoneal, visceral, and epididyimal adipose tissue depots, and glycemicand triglyceride levels, with no change in food intake and cholesterol levels. Furthermore, the HFD-GUA group presented an increase in VO and basal energy expenditure (EE), as well as,,,,, andexpression in the muscle and brown adipose tissue. In addition, the HFD-GUA group presented an increase in mtDNA (mitochondrial deoxyribonucleic acid) content in the muscle when compared to the HFD group. Thus, our data showed that guarana leads to an increase in energetic metabolism and stimulates mitochondrial biogenesis, contributing to control of weight gain, even when associated with high-fat diet.

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06:37

Guava leaf extract has the great ability to cut back plasma glucose and oxidative stress and conjointly ameliorates the burden of inflammation. GreenMedInfo

PMID:  Biomed Res Int. 2018 ;2018:4601649. Epub 2018 Feb 18. PMID: 29670899 Abstract Title:  Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats. Abstract:  Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM). Notably, guava leaf has been used to treat diabetes in Asia. Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM. A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals. Rats were treated with GLE at different concentrations (100, 200, and 400mg/kg b.w.). The standard drug glibenclamide (GB) (600g/kg b.w.) was used for comparison. The diabetic rats showed a reduced level of insulin, accompanied by exaggerated levels of blood glucose, lipid peroxidation product, and augmented expressions of inflammatory cytokines, and showed reduced levels of antioxidants compared to the control rats. Supplementation with GLE counteracted the consequences of STZ. It suppresses the oxidative stress and inhibits the state of inflammation and the results are almost similar to that of standard drug group (GB group 5). Our present research, therefore, provides useful data concerning guava leaf extract by a thorough assessment in diabetes management. Being a natural product, additional analysis on GLE can shed light on finding effective phytochemicals within the field of diabetes mellitus.

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06:36

Study: Cannabis More Effective Than Pharmaceutical Drugs for Age-Related Neurodegenerative Diseases Like Alzheimers Health Impact News

Willie_Nelson_at_Farm_Aid

Singer and song-writer Willie Nelson, a known avid marijuana user, is still going strong at age 85. Image Source.

by Paul Fassa
Health Impact News 

The prevailing safety concerns about marijuana from mainstream medicine, mainstream media, and government officials are focused on the brain. Somehow getting high on pot is associated with brain damage. And brain damage is the battle cry of marijuana prohibitionists. 

This is one factor that has contributed toward cannabidiols (CBD) more widespread acceptance for medicinal purposes for children and adults. 

CBD is without THC (tetrahydrocannabinol), the cannabinoid among over 100 in cannabis that has the psychotropic effect of euphoria for most. The few who get disturbed from this effect are often unable to go with the flow and experience confusion, anxiety, fear, or paranoia. 

But these negative sensations do not induce physiological brain damage, and its possible for some individuals to suffer psychologically from an adverse mental effect with just about any mental or emotional trauma.  

An earlier Health Impact News article presented the truth about this myth and how it started. It also provides information that points out the fact that cannabis is a brain health herb. 

In fact, full spectrum cannabis with THC included has been reported empirically by individuals and scientific studies to do the opposite of damaging the brain: It apparently heals brain damage. 

Study Demonstrates THCs Ability to Reverse Amyloid Plaque

A June 2016 in-vitro study titled, Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids, published in Nature Partner Journal Aging and Mechanics of Disease, used a cultured brain tissue to better study the biochemical and cellular mechanics...

06:14

Are People with Anxiety Actually Superheroes? Healthy Holistic Living

Restlessness. Shortness of breath. Difficulty concentrating. Sleep difficulties. Pounding heart. Feeling of impending doom. Panic attacks. Trembling. Sweating. Do these symptoms sound like they belong to a superhero? Hardly! Anxiety is a commonly diagnosed illness in todays day and age; arguably the most common mental illness in the United States(1). Anxiety effects over 40 million... View Article

The post Are People with Anxiety Actually Superheroes? appeared first on Healthy Holistic Living.

06:10

The Reason to Ditch Dryer Sheets Healthy Holistic Living

Everyone hates pulling their clothes out of the dryer to find a bundle of static shock ridden fabric. Do you use dryer sheets? Most people do, but did you know that they are loaded with toxic chemicals that can harm your health? Fortunately, there are natural alternatives to commercial laundry products: you can make your... View Article

The post The Reason to Ditch Dryer Sheets appeared first on Healthy Holistic Living.

06:02

The effect of Guarana on metabolic and inflammatory parameters in adult male mice programmed by maternal obesity. GreenMedInfo

PMID:  Eur J Nutr. 2018 Apr 6. Epub 2018 Apr 6. PMID: 29626231 Abstract Title:  The effect of Guarana (Paullinia cupana) on metabolic and inflammatory parameters in adult male mice programmed by maternal obesity. Abstract:  PURPOSE: Maternal obesity can program the offspring, increasing the risk of overweight and obesity in adult life. Guarana (Paullinia cupana) is a Brazilian plant that has weight-reducing effects. Thus, this study aimed to evaluate the effects of Guarana on metabolic and inflammatory parameters in mice programmed by maternal obesity.METHODS: Swiss female mice were divided into two groups: control and high fat (HF), who received a standard diet or a high-fat diet (HFD), respectively, for 8 weeks prior to mating, gestation, and lactation. After post-natal day (PN) 21, the offspring of the HF group were subdivided into three groups: HF without treatment; HF early treatment, offspring treated with Guarana (1 g/kg bodyweight) in PN25-PN30; HF late treatment, offspring treated with Guarana (1 g/kg bodyweight) in PN65-PN75. Basal energy expenditure, the lipid profile and fasting glucose levels were determined. Body composition was evaluated by dissecting adipose tissue depots. Gene expression was analyzed using real-time PCR.RESULTS: During mating, the weight of HF females increased; after lactation, their adipose tissue depots and fasting glycemic levels also increased. The offspring of the HF group showed an increased body weight at PN21. At PN80, in the mice treated with Guarana (with both treatments), VOand energy expenditure increased, adipose tissue depots decreased, and the expression of leptin, IL-6, TNF-, and MCP-1 decreased compared with that in the HF group.CONCLUSIONS: Guarana treatment at both stages of life reversed some of the alterations developed by the offspring of HF animals in adult life.

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05:55

The results indicated that six flavonoids from Psidium guajava exhibited significant antioxidant effects. GreenMedInfo

PMID:  Zhongguo Zhong Yao Za Zhi. 2018 Feb ;43(4):760-765. PMID: 29600652 Abstract Title:  [Study on antioxidant activity of flavonoids from leaves of Psidium guajava]. Abstract:  The present study is to study the chemical constituents from ethanol extract of Psidium guajava leaves. The constituents were separated and purified by silica gel column chromaiographios over, macroporous resin D-101, Sephadex LH-20, and ODS. Six flavonoids compounds were isolated and identified as quercetin(1), quercetin-3---D-arabinopyranoside(2), quercetin-3---D-ribopyranoside(3), quercetin-3---D-galactopyranoside(4), quercetin-3---D-glucopyranoside(5), and quercetin-3--D-xylpyranoside(6). The antioxidant effects of six flavonoids was evaluated by scavenging ability of DPPH, superoxide anion, ABTS, and reducing effect of Fe as well as total antioxidant capacity(FRAP). Vitamin C was used as positive control. The results indicated that six flavonoids exhibited significant antioxidant effects.

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05:44

Antiparasitic effect of the Psidium guajava and Psidium brownianum. GreenMedInfo

PMID:  Food Chem Toxicol. 2018 Mar 13. Epub 2018 Mar 13. PMID: 29548852 Abstract Title:  Antiparasitic effect of the Psidium guajava L. (guava) and Psidium brownianum MART. EX DC. (ara-de-veado) extracts. Abstract:  In the search for new therapeutic agents against neglected diseases, both aqueous and hydroethanolic extracts from Psidium guajava L. and P. brownianum Mart ex DC leaves were investigated regarding their antiparasitic effect and cytotoxic potential. The extracts were tested at three concentrations (250, 500 and 1000g/mL) against Trypanosoma cruzi epimastigote forms (Chagas, 1909), Leishmania braziliensis (Vianna, 1911) and L. infantum promastigotes forms (Nicolle, 1908), as well as against fibroblasts. P. guajava showed no activity against T. cruzi forms, while the hydroethanolic (PBHE), aqueous by decoction (PBAED) and aqueous by infusion (PBAEI) P. browninaum extracts were responsible, respectively, for inhibiting 100, 100 and 92.68% of T. cruzi epimastigote growth at the 1000g/mL concentration. The P. brownianum hydroethanolic extract (PBHE) at the highest concentration caused 58.46% death in L. braziliensis, thus demonstrating moderate activity, however when tested against L. infantum, the PBHE inhibited their growth by 37.16%, revealing its low activity. As for the cytotoxicity assays, the P. brownianum aqueous extract by decoction (PBAED) obtained the highest death percentage when compared to the others, causing 90.85% fibroblast mortality at the 1000g/mL concentration.

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05:33

Canada Supreme Court Orders New Trial for Non-vaccinating Parents Accused of Sons Death New Evidence Points to Cover-up of Medical Malpractice Vaccine Impact

Stephan family 2018

The Stephan family 2018. Photo source The New Agora.

by Health Impact News/MedicalKidnap.com Staff

The Supreme Court of Canada issued a stunning reversal this week in a case that could have far-reaching implications for parental rights. David and Collet Stephen were convicted last year of failing to provide the necessaries of life when their son Ezekiel died.

On Tuesday, May 15, 2018, justices in the highest court in the land deliberated for only a few minutes before issuing their unanimous decision. The Court could have waited months to render a decision, but Chief Justice Richard Wagner said that the consensus was that it was appropriate to release the decision as soon as possible.

Thus they gave a rare verdict from the bench on the same day that arguments were heard. Justice Michael Moldaver read the decision, stating that they would:

allow the appeal, quash the convictions, and order a new trial. (Source.)

According to a summary of the decision on the Supreme Court of Canada website, the justices found that the original:

trial judges charge to the jury was confusing, misleading and deficient in describing a key element of the offence, and that the trial judge did not properly instruct the jury on the fault element or the mens rea of the offence. (Source.)

David Stephan told Health Impact News that this was definitely good news. This puts their case basically back at square 1. While they are not looking forward to going through trial again, they are hopeful that they will be vindicated.

David Stephan Supreme Court victory

David Stephan was happy about the Supreme...

05:31

Canada Supreme Court Orders New Trial for Non-vaccinating Parents Accused of Sons Death New Evidence Points to Cover-up of Medical Malpractice Health Impact News

Stephan family 2018

The Stephan family 2018. Photo source The New Agora.

by Health Impact News/MedicalKidnap.com Staff

The Supreme Court of Canada issued a stunning reversal this week in a case that could have far-reaching implications for parental rights. David and Collet Stephen were convicted last year of failing to provide the necessaries of life when their son Ezekiel died.

On Tuesday, May 15, 2018, justices in the highest court in the land deliberated for only a few minutes before issuing their unanimous decision. The Court could have waited months to render a decision, but Chief Justice Richard Wagner said that the consensus was that it was appropriate to release the decision as soon as possible.

Thus they gave a rare verdict from the bench on the same day that arguments were heard. Justice Michael Moldaver read the decision, stating that they would:

allow the appeal, quash the convictions, and order a new trial. (Source.)

According to a summary of the decision on the Supreme Court of Canada website, the justices found that the original:

trial judges charge to the jury was confusing, misleading and deficient in describing a key element of the offence, and that the trial judge did not properly instruct the jury on the fault element or the mens rea of the offence. (Source.)

David Stephan told Health Impact News that this was definitely good news. This puts their case basically back at square 1. While they are not looking forward to going through trial again, they are hopeful that they will be vindicated.

David Stephan Supreme Court victory

David Stephan was happy about the Supre...

05:29

My OWN amazing holistic MD shutting down practice, fears his license may be revoked, by Erin Elizabeth Health Nut News

Im so frustrated right now after having just learned that MY holistic MD, the man I trusted, who helped me with Lyme disease, will be shutting down his practice on July 13, 2018. Heres his story below. I have seen two doctors in Seattle. Dr Marty Ross and Dr Dietrich Klinghardt. Forgive Dr Ross spelling []

The post My OWN amazing holistic MD shutting down practice, fears his license may be revoked, by Erin Elizabeth appeared first on Health Nut News.

05:26

Magnesium chloride neutralized the effects of chlorpyrifos. GreenMedInfo

PMID:  Pharmacol Res Perspect. 2018 Jun ;6(3):e00401. Epub 2018 Apr 30. PMID: 29736246 Abstract Title:  Effects of magnesium chloride on in vitro cholinesterase and ATPase poisoning by organophosphate (chlorpyrifos). Abstract:  The present study investigated possible benefits of magnesium ion (as MgCl) in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes. Blood samples collected from volunteered healthy adult by venepuncture into anticoagulant test tubes containing EDTA were separated into plasma and red blood cell and divided into three groups namely: normal, pesticide only (0.25-2.0 mmol/L chlorpyrifos) and pesticide (0.25-2.0 mmol/L chlorpyrifos) + 0.1 mol/L MgCl. Acetylcholinesterase, Na/KATPase and CaATPase activities were evaluated. Results showed that Chlorpyrifos significantly ( 

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05:18

Alpha-lipoic acid could protect against chlorpyrifos and deltamethrin. GreenMedInfo

PMID:  Environ Sci Pollut Res Int. 2018 May 7. Epub 2018 May 7. PMID: 29736639 Abstract Title:  Chronic co-exposure to chlorpyrifos and deltamethrin pesticides induces alterations in serum lipids and oxidative stress in Wistar rats: mitigating role of alpha-lipoic acid. Abstract:  The study evaluated the effect of combination of chlorpyrifos (CPF) and deltamethrin (DLT) on serum lipid profiles and oxidative stress in rats, and the mitigating role of alpha-lipoic acid (ALA). Thirty male rats were used for the 120-day study. Serum samples obtained at termination were evaluated for the levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), malondialdehyde (MDA), and the activities of antioxidant enzymes. The levels of low-density lipoprotein-cholesterol (LDL), very low-density lipoprotein-cholesterol (VLDL), and atherogenic index (AI) were calculated. The pesticide combination elevated the levels of TG, TC, LDL, VLDL, AI, and MDA, and decreased HDL level, and activities of CAT, SOD, and GPx. The alterations induced by CPF and DLT were alleviated by ALA, partly through its antioxidant properties. In conclusion, co-exposure to DLT and CPF altered serum lipids and increased oxidative stress changes in the rats, which were ameliorated by ALA.

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05:07

An extract of P. guajava leaves and its isolated quercetin fraction have a hypolipidemic activity against carbon tetrachloride induced hepatotoxicity. GreenMedInfo

PMID:  Pharmacogn Mag. 2018 Jan-Mar;14(53):4-8. Epub 2018 Feb 20. PMID: 29576694 Abstract Title:  Hypolipidemic Effect ofLeaf Extract Against Hepatotoxicity in Rats. Abstract:  Background: Plant-based natural extracts cure several diseases in human. However, the extract ofleaf is not yet evaluated on changes of lipid profile in hepatic disease affected rats.Objective: The present study was aimed to evaluate the mitigation effect of the ethanolic extract ofleaf and its isolated quercetin fraction on hepatotoxic rats.Materials and Methods: Carbon tetrachloride (CCl) was injected to rats for hepatic disease induction and silymarin drug was used as positive control to compare plant ethanolic extract. The lipid profiles were assessed in both plasma and liver tissue of diseased and control rats.Results: Levels of total cholesterol, triglycerides, free fatty acids, phospholipids, and low-density lipoprotein cholesterol were increased and the level of high-density lipoprotein cholesterol (HDL-C) was decreased in CCl-induced hepatotoxic rats. The treatment of(100, 200, and 300 mg/kg, bw) and isolated quercetin fraction (20 mg/kg, bw) doses decreased the elevated levels of all these parameters in diseased rats and restored the normal concentration of HDL-C.Conclusion: The results of the present study concluded that theleaf and its isolated quercetin fraction can significantly regulate lipid metabolism in CCl-induced hepatotoxic rats and decrease the disease rate.SUMMARY: leaf extract reduces the hepatotoxicity and disease rate in ratsQuercetin fraction of leaf extract significantly regulates lipid profile in hepatic diseased rats.CCl: Carbon tetrachloride; FFA: Free fatty acids; HDL-C: High-density lipoprotein cholesterol; LCAT: Lecithin cholesterol acyltransferase; LDL-C: Low-density lipoprotein cholesterol; PL: Phospholipids; TC: Total cholesterol; TG: Triglycerides; VLDL-C: Very low-density lipoprotein cholesterol.

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04:51

Continuous intake of guava leaf extract might relieve knee pain. GreenMedInfo

PMID:  Aging Clin Exp Res. 2018 Apr 23. Epub 2018 Apr 23. PMID: 29687303 Abstract Title:  Effects of Psidium guajava Linn. leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study. Abstract:  The extract of Psidium guajava Linn. (guava) leaf was recently revealed to suppress the advance of osteoarthritis (OA) in rat anterior cruciate ligament-transection models. To investigate the efficacy of guava leaf extract in improving knee pain, which is a common symptom of OA, we conducted a double-blind parallel pilot clinical study in Japanese subjects with knee pain. The subjects, who had no medical history of knee treatment, were randomly assigned to two groups with similar total Japanese Knee Osteoarthritis Measure (JKOM) scores. During the 12-week intake period, the subjects in each group ingested 1 g of guava leaf extract (the guava group) or placebo (the placebo group) daily. At week 12, pain and stiffness in knees (one subcategory of JKOM score) in the guava group was significantly lower than that in the placebo group. Using the visual analogue scale (VAS) for knee pain, a significant association between treatment effect and test period was shown, and the guava group had a lower VAS score at week 12 than the placebo group. In conclusion, continuous intake of guava leaf extract might relieve knee pain, suggesting a potential preventive effect against OA symptoms.

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04:47

Canada Supreme Court Orders New Trial for Non-vaccinating Parents Accused of Sons Death New Evidence Points to Cover-up of Medical Malpractice Medical Kidnap

Stephan family 2018

The Stephan family 2018. Photo source The New Agora.

by Health Impact News/MedicalKidnap.com Staff

The Supreme Court of Canada issued a stunning reversal this week in a case that could have far-reaching implications for parental rights. David and Collet Stephen were convicted last year of failing to provide the necessaries of life when their son Ezekiel died.

On Tuesday, May 15, 2018, justices in the highest court in the land deliberated for only a few minutes before issuing their unanimous decision. The Court could have waited months to render a decision, but Chief Justice Richard Wagner said that the consensus was that it was appropriate to release the decision as soon as possible.

Thus they gave a rare verdict from the bench on the same day that arguments were heard. Justice Michael Moldaver read the decision, stating that they would:

allow the appeal, quash the convictions, and order a new trial. (Source.)

According to a summary of the decision on the Supreme Court of Canada website, the justices found that the original:

trial judges charge to the jury was confusing, misleading and deficient in describing a key element of the offence, and that the trial judge did not properly instruct the jury on the fault element or the mens rea of the offence. (Source.)

David Stephan told Health Impact News that this was definitely good news. This puts their case basically back at square 1. While they are not looking forward to going through trial again, they are hopeful that they will be vindicated.

David Stephan Supreme Court victory

David Stephan was happy about the Supreme...

04:36

A Step Towards Health Freedom in Australia The Alliance for Natural Health

Consumers Down Under will have access to more information about alternative medicines.

A bill was recently approved in Australia that loosens some of the regulations governing advertising claims made by producers of alternative and complementary products. The Therapeutic Goods Amendment Bill 2017 creates a list of permitted indications which can be used in advertising without having to jump through the bureaucratic hoops previously required. Crucially, the list includes indications supported by traditional evidence. Australian lawmakers also rejected amendments to the bill that would have slapped natural products with a disclaimersimilar to what the FTC now requires for homeopathic products in the USthat would have read: This traditional indication is not in accordance with modern medical knowledge and there is no scientific evidence that this product is effective.

Were glad Australians have fought back efforts to restrict the information available to consumers about natural medicine. Take action to protect free speech in the US by supporting two Citizens Petitions for health claims about cranberries helping with urinary tract infections and vitamin Ds role in preventing preterm births.

04:27

Guava leaf inhibits hepatic gluconeogenesis and increases glycogen synthesis. GreenMedInfo

PMID:  Biomed Pharmacother. 2018 Apr 24 ;103:1012-1017. Epub 2018 Apr 24. PMID: 29710658 Abstract Title:  Guava leaf inhibits hepatic gluconeogenesis and increases glycogen synthesis via AMPK/ACC signaling pathways in streptozotocin-induced diabetic rats. Abstract:  Psidium guajava (PG) is a short shrub or tree cultivated in tropical and subtropical regions around the world. The leaf extract of PG (guava leaf) has been used historically to cure many ailments. However, mechanisms of action of guava leaf in treating diabetes are not fully understood. Effects and underlying mechanisms of guava leaf on gluconeogenesis and glycogenesis in hepatocytes, insulin signaling proteins, liver function markers, and lipid profile in streptozotocin (STZ) injected diabetic Wistar rats were investigated within the current study. PG was given orally at the dose of 100, 200, and 400mg/kg b.w to diabetic rats for the period of 45 days. The results reveal that oral administration of PG (200mg/kg b.w) has considerably raised the levels of insulin, glycogen, hexokinase, glucose-6-phosphatase dehydrogenase and significant (p

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03:55

Guava and vitamin C has a preventive effect on the development of experimental gingivitis. GreenMedInfo

PMID:  J Clin Periodontol. 2018 May 14. Epub 2018 May 14. PMID: 29757462 Abstract Title:  Effect of guava and vitamin C supplementation on experimental gingivitis A randomized clinical trial. Abstract:  OBJECTIVE: To study the effect of guava and synthetic vitamin C on the development of gingival inflammation during experimental gingivitis.MATERIAL AND METHODS: Participants were randomly assigned to three groups supplemented daily with either 200g guava, 200mg synthetic vitamin C or water. The study included a 14 days pre-experimental period with oral hygiene instructions, scaling, prophylaxis and supplementation. Thereafter, experiment gingivitis was initiated, while continuing supplementation. At baseline, day 7 and day 14 of experimental gingivitis, Plaque Index (PlI) and Gingival Index (GI) were assessed. During the entire study, dietary fruit/vegetables intake was minimal.RESULTS: PlI increased in guava-, vitamin C- and control group (PlI: 1.30, 1.61 and 1.79 respectively). However, the guava group developed significantly less plaque compared to the control group. The GI increase of both guava- and vitamin C group was significantly less than the increase of the control group (GI: 0.10, 0.24 and 0.87 respectively).CONCLUSION: in a population of young non-smoking adults, consumption of either 200g guava/day or 200mg synthetic vitamin C/day, prior to and during the oral hygiene abstention period, has a preventive effect on the development of experimental gingivitis as compared to the control group that developed the usual amount of experimental gingivitis. This article is protected by copyright. All rights reserved.

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03:36

These results show significant beneficial effects of vitamins C and E in reducing the risk of cognitive decline in women with APOE E4 and men without APOE E4. GreenMedInfo

PMID:  J Alzheimers Dis. 2018 May 11. Epub 2018 May 11. PMID: 29758939 Abstract Title:  Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study. Abstract:  BACKGROUND: Antioxidants like vitamins C and E may minimize the risk for Alzheimer's disease.OBJECTIVE: We examined whether vitamins C and E modify the apolipoprotein E (APOE) E4-related risks for developing cognitive decline.METHODS: We conducted a population-based prospective study including Japanese residents aged 65 years from Nakajima, Japan. The participants received an evaluation of cognitive function and underwent blood tests including tests for vitamins C and E levels and APOE phenotypes. The APOE E4-by-gender-by-vitamin C or E interactions on developing cognitive decline were analyzed.RESULTS: Of 606 participants with normal cognitive function determined using a baseline survey (2007-2008), 349 completed the follow up survey between 2014 and 2016. In women with APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin C concentration tertile [multivariate OR 0.10 (95% CI 0.01-0.93)] compared with the lowest tertile. In men without APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin E concentration tertile [multivariate OR 0.19 (0.05-0.74)] as compared with the lowest tertile.CONCLUSION: Our results demonstrate significant beneficial effects of vitamins C and E in reducing the risk of cognitive decline in women with APOE E4 and men without APOE E4, respectively.

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03:26

Hypoadrenalism, Stress And Microwaves Natural Blaze

By Catherine J. Frompovich

As a retired healthcare professional but a still-active consumer health issues researcher and writer, theres something I think high tech devices and Wi-Fi users ought to know, plus factor into the equation of constant exposures to microwaves, 4G and 5G, and all the in-home smart appliances, which rely on microwaves to power them and report back to big brother your usage profiles.

Utility companies AMI Smart Meters also become a huge factor in electromagnetic hypersensitivity (EHS) or medically called idiopathic electromagnetic intolerance (IEI), which now is estimated to affect about one-third of the population.

Theres a health condition most often overlooked by diagnosticians called Hypoadrenalism which, years ago when I did my studies, was called Hypoadrenia. Its a most debilitating disorder affecting the adrenal glands that leaves one with very little energy no matter how or what one tries to increase ones energy.

Do you find strong coffee no longer gives you that quick pick up? Even that former reliable chocolate candy bar no longer works its magic to keep you moving along after 3PM daily. First and foremost, besides ruling out blood sugar metabolism problems, e.g., hypoglycemia or diabetes, one ought to research the negative health effects of electromagnetic frequencies upon the human organism, wh...

03:17

Intravenous ascorbic may be useful in symptom management and improving quality of life in cancer patients. GreenMedInfo

PMID:  Integr Cancer Ther. 2018 May 1:1534735418775809. Epub 2018 May 1. PMID: 29771164 Abstract Title:  Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer. Abstract:  BACKGROUND: Intravenous ascorbic acid (IV AA) has been used extensively in cancer patients throughout the United States. Currently, there are limited data on the safety and clinical effects of IV AA. The purpose of this study was to expand the current literature using a retrospective analysis of adverse events and symptomatic changes of IV AA in a large sample of cancer patients.METHODS: We conducted a retrospective chart review of all patients receiving IV AA for cancer at the Thomas Jefferson University Hospital over a 7-year period. We assessed all reports of adverse events, laboratory findings, and hospital or emergency department admissions. We also reviewed quality-of-life data, including fatigue, nausea, pain, appetite, and mood.RESULTS: There were 86 patients who received a total of 3034 doses of IV AA ranging from 50 to 150g. In all, 32 patients received only ascorbic acid as part of their cancer management (1197 doses), whereas 54 patients received ascorbic acid in conjunction with chemotherapy (1837 doses). The most common adverse events related to ascorbic acid were temporary nausea and discomfort at the injection site. All events reported in the ascorbic acid alone group were associated with less than 3% of the total number of infusions. Patients, overall, reported improvements in fatigue, pain, and mood while receiving ascorbic acid.CONCLUSIONS: The results of this retrospective analysis support the growing evidence that IV AA is generally safe and well tolerated in patients with cancer, and may be useful in symptom management and improving quality of life.

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02:56

Zooplankton may be particularly susceptible to negative impacts of exposure to microplastic pollution. GreenMedInfo

PMID:  Sci Total Environ. 2018 Aug 1 ;631-632:550-559. Epub 2018 Mar 16. PMID: 29529442 Abstract Title:  A meta-analysis of the effects of exposure to microplastics on fish and aquatic invertebrates. Abstract:  Microplastics are present in aquatic ecosystems the world over and may influence the feeding, growth, reproduction, and survival of freshwater and marine biota; however, the extent and magnitude of potential effects of microplastics on aquatic organisms is poorly understood. In the current study, we conducted a meta-analysis of published literature to examine impacts of exposure to microplastics on consumption (and feeding), growth, reproduction, and survival of fish and aquatic invertebrates. While we did observe within-taxa negative effects for all four categories of responses, many of the effects summarized in our study were neutral, indicating that the effects of exposure to microplastics are highly variable across taxa. The most consistent effect was a reduction in consumption of natural prey when microplastics were present. For some taxa, negative effects on growth, reproduction and even survival were also evident. Organisms that serve as prey to larger predators, e.g., zooplankton, may be particularly susceptible to negative impacts of exposure to microplastic pollution, with potential for ramifications throughout the food web. Future work should focus on whether microplastics may be affecting aquatic organisms more subtly, e.g., by influencing exposure to contaminants and pathogens, or by acting at a molecular level.

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02:44

Negative effects of microplastic exposure on growth and development of Crepidula onyx. GreenMedInfo

PMID:  Environ Pollut. 2018 Feb ;233:588-595. Epub 2017 Nov 5. PMID: 29107898 Abstract Title:  Negative effects of microplastic exposure on growth and development of Crepidula onyx. Abstract:  Microplastics exposure could be detrimental to marine organisms especially under high concentrations. However, few studies have considered the multiphasic nature of marine invertebrates' life history and investigated the impact of experiencing microplastics during early development on post-metamorphic stages (legacy effect). Many planktonic larvae can feed selectively and it is unclear whether such selectivity could modulate the impact of algal food-sized microplastic. In this two-stage experiment, veligers of Crepidula onyx were first exposed to additions of algae-sized micro-polystyrene (micro-PS) beads at different concentrations, including ones that were comparable their algal diet. These additions were then either halted or continued after settlement. At environmentally relevant concentration (ten 2-m microplastic beads ml), larval and juvenile C. onyx was not affected. At higher concentrations, these micro-PS fed larvae consumed a similar amount of algae compared to those in control but grew relatively slower than those in the control suggesting that ingestion and/or removal of microplastic was/were energetically costly. These larvae alsosettled earlier at a smaller size compared to the control, which could negatively affect post-settlement success. Juvenile C. onyx receiving continuous micro-PS addition had slower growth rates. Individuals only exposed to micro-PS during their larval stage continued to have slower growth rates than those in the control even if micro-PS had been absent in their surroundings for 65 days highlighting a legacy effect of microplastic exposure.

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02:23

First Anti-Geoengineering Billboard Goes Up In New York City Geoengineering Watch

GW3342Dane Wigington GeoengineeringWatch.org Another GeoengineeringWatch.org billboard goes up in our ongoing and rapidly intensifying effort to expose the climate engineering insanity to the public. This billboard, the latest of many, is on the Long Island Expressway in New York City, New York. It is visible to eastbound traffic that is exiting Manhattan, just across the river from the United Nations headquarters and

02:17

Microplastics and polycyclic aromatic hydrocarbons in Xiamen coastal areas: Implications for anthropogenic impacts. GreenMedInfo

PMID:  Sci Total Environ. 2018 Sep 1 ;634:811-820. Epub 2018 Apr 10. PMID: 29653425 Abstract Title:  Microplastics and polycyclic aromatic hydrocarbons (PAHs) in Xiamen coastal areas: Implications for anthropogenic impacts. Abstract:  Microplastics and polycyclic aromatic hydrocarbons (PAHs) were investigated to study the influence of human activities and to find their possible relationship on the coastal environments, where the coastal areas around Xiamen are undergoing intensive processes of industrialization and urbanization in the southeast China. The abundance of microplastics in Xiamen coastal areas was 103 to 2017particles/min surface seawater and 76 to 333 particles/kg in sediments. Concentrations of dissolved PAHs varied from 18.1 to 248ng/L in surface seawater. The abundances of microplastics from the Western Harbor in surface seawater and sediments were higher than those from other areas. Foams were dominated in surface seawater samples, however, no foams were found in sediments samples. The microscope selection and FTIR analysis suggested that polyethylene (PE) and polypropylene (PP) were dominant microplastics. The cluster analysis results demonstrated that fibers and granules had the similar sources, and films had considerably correlation with all types of PAHs (3 or 4-ring PAHs and alkylated PAHs). Plastic film mulch from agriculture practice might be a potential source of microplastics in study areas. Results of our study support that river runoff, watershed area, population and urbanization rate influence the distribution of microplastics in estuarine surface water, and the prevalence of microplastic pollution calls for monitoring microplastics at a national scale.

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02:17

Cholera Vaccine Not As Effective As Claimed, Heres the Real Reason Disease Went Down Natural Blaze

cholera vaccine

By Brandon TurbevilleNatural Blaze

Additionally, the cholera attack rate of the nonvaccinated group was overestimated. 

It has long been known that clean water and sanitation lead to better health among the human population. However, vaccine nazis have for just as long attempted to deny the correlation and argue that the increase standards of public health were due to vaccines. Among unbiased researchers, however, that perception cannot help but go unchallenged.

SEE: Biotech Wants To Experiment On Aussies GMO Cholera Vax

In 2016, a number of researchers wrote to The American Society of Tropical Medicine and Hygiene to question the effectiveness of the oral cholera vaccine deployed in Haiti. To be clear, the researchers were not questioning the safety of the vaccine or vaccines in general but that the effectiveness of the vaccine had been overestimated by previous research teams.

Their argument was that the vaccine was tested alongside increased sanitation practices, possibly over-inflating the success rate of the shot. They argued that the vaccine should have been tested and evaluated by itself.

02:11

Characterization of microplastic litter in the gastrointestinal tract of Solea solea from the Adriatic Sea. GreenMedInfo

PMID:  Environ Pollut. 2018 Mar ;234:943-952. Epub 2017 Dec 21. PMID: 29665634 Abstract Title:  Characterization of microplastic litter in the gastrointestinal tract of Solea solea from the Adriatic Sea. Abstract:  Micro-plastic particles in the world's oceans represent a serious threat to both human health and marine ecosystems. Once released into the aquatic environment plastic litter is broken down to smaller pieces through photo-degradation and the physical actions of waves, wind, etc. The resulting particles may become so small that they are readily taken up by fish, crustaceans and mollusks. There is mounting evidence for the uptake of plastic particles by marine organisms that form part of the human food chain and this is driving urgent calls for further and deeper investigations into this pollution issue. The present study aimed at investigating for the first time the occurrence, amount, typology of microplastic litter in the gastrointestinal tract of Solea solea and its spatial distribution in the northern and central Adriatic Sea. This benthic flatfish was selected as it is a species of high commercial interest within the FAO GFCM (General Fisheries Commission for the Mediterranean) area 37 (Mediterranean and Black Sea) where around 15% of the overall global Solea solea production originates. The digestive tract contents of 533 individuals collected in fall during 2014 and 2015 from 60 sampling sites were examined for microplastics. These were recorded in 95% of sampled fish, with more than one microplastic item found in around 80% of the examined specimens. The most commonly found polymers were polyvinyl chloride, polypropylene, polyethylene, polyester, and polyamide, 72% as fragments and 28% as fibers. The mean number of ingested microplastics was 1.73  0.05 items per fish in 2014 and 1.64  0.1 in 2015. PVC and PA showed the highest densities in the northern Adriatic Sea, both inshore and off-shore while PE, PP and PET were more concentrated in coastal areas with the highest values offshore from the port of Rimini.

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01:43

Arctic sea ice is an important temporal sink and means of transport for microplastic. GreenMedInfo

PMID:  Nat Commun. 2018 Apr 24 ;9(1):1505. Epub 2018 Apr 24. PMID: 29692405 Abstract Title:  Arctic sea ice is an important temporal sink and means of transport for microplastic. Abstract:  Microplastics (MP) are recognized as a growing environmental hazard and have been identified as far as the remote Polar Regions, with particularly high concentrations of microplastics in sea ice. Little is known regarding the horizontal variability of MP within sea ice and how the underlying water body affects MP composition during sea ice growth. Here we show that sea ice MP has no uniform polymer composition and that, depending on the growth region and drift paths of the sea ice, unique MP patterns can be observed in different sea ice horizons. Thus even in remote regions such as the Arctic Ocean, certain MP indicate the presence of localized sources. Increasing exploitation of Arctic resources will likely lead toa higher MP load in the Arctic sea ice and will enhance the release of MP in the areas of strong seasonal sea ice melt and the outflow gateways.

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01:36

Scientists Will Now Kill More Bees to Get Their BacteriaTo Help the Bees Natural Blaze

probiotics bees

By Heather Callaghan, Natural Blaze

Probiotics are a Bandage on Colony Collapse Disorder But Cause More Problems while they have been shown to help bees withstand threats like fungal infection and pesticides is it worth the price bees pay?

Previously, commercial probiotics have helped boost bees immune systems to withstand pesticides and fungal infection. But now scientists have harvested bacteria from bees own intestines to use instead to fight the fungal nosemosis. While we need urgent solutions for bee decline, we just have to ask.is this worth it?

Universit Laval reports:

Adding probiotics to bees food helps make them more resistant to nosemosis, a fungal infection associated with colony collapse disorder that has been observed in Europe and North America over the past 20 years. Probiotics can decrease the mortality rate of this infection in bees by up to 40%, report researchers at Universit Laval in the most recent edition of Frontiers in Ecology and Evolution.

Nosemosis, also called nosema disease, is caused by Nosema ceranae, a single-celled fungus of Asian origin that bees ingest with their food and that grows in the cells of their intestinal walls. Under normal conditions, this fungus does not cause any problems for bees, explains N...

01:35

These results will improve our understanding of the environmental risks posed by microplastics to marine ecosystems. GreenMedInfo

PMID:  Sci Total Environ. 2018 Apr 24 ;636:20-29. Epub 2018 Apr 24. PMID: 29702399 Abstract Title:  Microplastic pollution in North Yellow Sea, China: Observations on occurrence, distribution and identification. Abstract:  Microplastics are emerging contaminants and have attracted widespread environmental concerns about their negative effects on the marine ecosystems. In this study, we investigated the abundances, distributions and characteristics of microplastics in surface seawater and sediments from the North Yellow Sea. The results showed that the abundance of microplastics was 545282items/min surface seawater and 37.142.7items/kg dry weight in sediments, representing a medium microplastic pollution level compared with other sea areas. Small microplastics (70% of the total microplastic numbers. Films and fibers were the dominant shapes of microplastics in both the surface seawater and sediments. Transparent microplastics were generally more common than microplastics of other colors. Based on the identification by a Fourier transform infrared microscope, polyethylene (PE) was the dominant composition of microplastics in surface seawater, while polypropylene (PP) was the most common polymer type in sediments. These results will improve our understanding of the environmental risks posed by microplastics to marine ecosystems.

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01:25

Large quantities of microplastics with small particle sizes were found in the South China Sea. GreenMedInfo

PMID:  Sci Total Environ. 2018 Aug 15 ;633:1206-1216. Epub 2018 Mar 30. PMID: 29758873 Abstract Title:  Lost but can't be neglected: Huge quantities of small microplastics hide in the South China Sea. Abstract:  Large quantities of microplastics with small particle sizes were found in the South China Sea (SCS). The abundances of microplastics in seawater were 0.0450.093and 25691770particles/maccording to the bongo net and pumping sampling methods, respectively. Smaller-size fractions (size

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01:08

Microplastics can also transfer POPs not only via ingestion, but also by simple attachment to epithelia. GreenMedInfo

PMID:  Environ Pollut. 2018 Apr ;235:918-930. Epub 2018 Feb 21. PMID: 29751397 Abstract Title:  Microplastic accumulation patterns and transfer of benzo[a]pyrene to adult zebrafish (Danio rerio) gills and zebrafish embryos. Abstract:  Since only a few studies have investigated effects of microplastics (MPs) by routes other than ingestion, this study was designed to analyze the accumulation patterns and transfer of toxic substances associated with microplastic exposure by simple attachment to (1) adult zebrafish (Danio rerio) gills and (2) zebrafish embryos. Two sizes of fluorescently labelled polymers (1-5 and 10-20m) loaded with the model polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BaP) were used to analyze fate, accumulation and transfer of microplastic-associated persistent organic pollutants (POPs) on gills and embryos. Results indicate that microplastics did not permanently accumulate at high amounts in adult zebrafish gills after 6 nor 24h of incubation: Most particles only superficially adhered to the mucus layer on the filaments, which is constantly being excreted. In contrast, the smaller and heavier MPs (1-5m) accumulated in high numbers on the surface of zebrafish egg chorions. In both exposure scenarios, transfer of BaP could be visualized with fluorescence microscopy: A prominent BaP signal was visible both in gill filaments and arches after 6 and 24h incubation and in zebrafish embryos after exposure to BaP-spiked microplastics. Furthermore, the gill EROD (Ethoxyresorufin-O-deethylase) assay showed a clear trend to CYP 1A (Cytochrom P450 1 A) induction via exposure to BaP-spiked microplastics. However, BaP from spiked microplastics did not reach sufficiently high concentrations to be able to induce morphological effects in the fish embryo toxicity test(FET). In contrast, control exposure to waterborne BaP did induce effects in the FET. As a conclusion, microplastics can also transfer POPs not only via ingestion, but also by simple attachment to epithelia or via the water column. However, further studies are needed to clarify if these interactionsare of environmental concern relative to waterborne exposure to toxic substances.

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00:29

Vax-Unvax study of mice implicates Hepatitis B vaccineMedia Silent Health Nut News

By World Mercury Project Board Member JB Handley, Co-Founder, Generation Rescue GUANDONG, China Sun Yat-sen Universitys (a Top 10 university in China) Dr. Zhibin Yao is not a household name in the American autism community, but perhaps he should be. Not only is he American-educated (University of Pittsburgh) and the author of 33 peer-reviewed studies, but hes also the lead author of two []

The post Vax-Unvax study of mice implicates Hepatitis B vaccineMedia Silent appeared first on Health Nut News.

00:18

Calling for Overhaul of Nations Food System, New Campaign Seeks Ban on Factory Farms Natural Blaze

Calling for Overhaul of Nation's Food System, New Campaign Seeks Ban on Factory Farms

Farmers, environmental advocates, and community leaders came together in Des Moines, Iowa on Monday to launch a national campaign to outlaw factory farming, in conjunction with a new report that outlines the long list of negative consequences tied to housing hundreds or thousands of animals in crowded spaces.

This is a model that doesnt work for the way we produce our food. It doesnt work for the environment. It doesnt work for public health. It doesnt work for communities. It doesnt work for family farmers And its time to say, no more.'
Patty Lovera,
Food & Water Watch

Noting that the number of industrial farms across the United States has soared over the past two decades, the report (pdf) by Food & Water Watch details how these operations produce enormous volumes of waste, pollute the air and water, exploit workers, harm animal welfare, fuel antibiotic resistance and climate change, and harm the rural communities they are purported to benefit.

Wenonah Hauter, the groups executive director, compared the national campaign to halt all factory farming to grassroots efforts in 2011 to ban the natural gas extracti...

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23:55

May be more slimming than working out in a gym, and nearly everyone can do it Health Nut News

By Dr. Mercola While a regimented fitness routine is certainly part of a healthy lifestyle, what you do outside the gym is equally important. Most adults spend 10 hours or more each day sitting, and research shows this level of inactivity cannot be counteracted with a workout at the end of the day. To maintain health, []

The post May be more slimming than working out in a gym, and nearly everyone can do it appeared first on Health Nut News.

23:39

How to Make Homemade Mosquito Repellent That Works REALfarmacy.com

Source: How to Make Homemade Mosquito Repellent That Works For more content like this visit REALfarmacy.com.

The bugs are out in full force this year! Protect yourself with the following effective recipe: Combine in a 16oz bottle: 15 drops of lavender oil 10 drops of lemon eucalyptus oil 4 Tbsp of vanilla extract 1/4 cup of lemon juice Fill with water and shake via SurvivingTheStores.com You may []

Source: How to Make Homemade Mosquito Repellent That Works Learn more at REALfarmacy.com - Healthy News and Information.

23:36

Survey Claiming Millennials Like GMOs Ridiculously Biased and Manipulated Natural Blaze

By Heather Callaghan, Natural Blaze

Millennials lead the charge against GMOs and have more in common with their grandparents than their parents generation. Millennials are reviving the art of gardening, local food and food preservation so it shouldnt be surprising to find thousands of them at the March Against Monsanto. Yet a new survey is attempting to influence the public that it is millennials who love GMOs.

A new survey, according to the Telegraph, declared that Millennials have no qualms about GM crops unlike older generation. Most people read headlines and headlines like this cast a major influence. All the propaganda is right in the title. First, it is falsely claiming that millennials have embraced genetic engineering of their food. Second, by mentioning the older generation and claiming they are against GMOs, the survey casts a subtle message that if you dont accept GMOs you are stodgy and archaic, instead of hip and open-minded like the supposed millennials.

But is that what the survey was about at all??

GM Watch reports on the survey commissioned by the GM industry body, the Agricultural Biotechnology Council (ABC), carried out by the polling firm Populus. At first, the actual survey wasnt made available with any links, which means journalists wrote articles without even checking. But then.:

perhaps in response to queries from skeptical members of the public...

23:09

Travis Allen: Californias Best Hope for Health Freedom? BolenReport

By Kent Heckenlively, JD Sometimes when it comes to health freedom and politicians I feel like Charlie Brown wanting to kick the football his friend Lucy has teed up for him. I want to believe this time a politician REALLY MEANS IT when they talk about health freedom and bringing back sanity and intelligence to Continue reading Travis Allen: Californias Best Hope for Health Freedom?

The post Travis Allen: Californias Best Hope for Health Freedom? appeared first on BolenReport.

22:23

The diet that starves cancer cells and reverses diabetes Health Nut News

(Note from Erin: Diets are not and cannot be one size fits all because we are all different. But check out this story and have an open mind. This might just work for your body!) Within the last couple of years, scientists and doctors have debunked the low-fat diet as healthy and the idea that []

The post The diet that starves cancer cells and reverses diabetes appeared first on Health Nut News.

22:00

Caught Our Notice: Hey peer reviewers did you even read this paper?? Retraction Watch

What Caught Our Attention: A tree of life paper has been axed and based on the information in the retraction notice, were wondering how it ever passed peer review. Specifically, the notice states a review of the paper found concerns regarding the study design, methodology, and interpretation of the data. Overall, the research contradict(s) Continue reading Caught Our Notice: Hey peer reviewers did you even read this paper??

21:27

The eco-friendly alternative to cremation and burial Health Nut News

By Dr. Mercola Most of you reading this article right now probably do your best to live a green and eco-friendly lifestyle. You likely buy local, organic and regenerative food when possible and use chemical-free cosmetics, personal care products and household cleaners. You may even recycle and drive an electric vehicle. These actions are commendable []

The post The eco-friendly alternative to cremation and burial appeared first on Health Nut News.

21:22

In Huge Win for Pollinators, People, and the Planet, EU bans bee-killing pesticides Health Nut News

Authorizing neonicotinoids during a quarter of a century was a mistake and led to an environmental disaster. Todays vote is historic. by Jessica Corbett, staff writer  (Note from Erin: This is AMAZING news. Lets hope we make this decision here in the United States soon. Before its too late to undo the damage weve already done.) []

The post In Huge Win for Pollinators, People, and the Planet, EU bans bee-killing pesticides appeared first on Health Nut News.

20:52

Recovery: Creating Your Personal Journey Through Self-Honesty, Resilience and Hope Mad In America

I am in recovery from mental illness. Ive always felt that the typical professional services were unable to provide the relief I needed. When I re-entered the workforce I focused my energy on these limitations. I became a peer specialista person in recovery trained in supportive counseling and advocacy. I also began earning my masters degree in psychiatric rehabilitation, a field dedicated to the idea of recovery, and one which takes a more holistic approach. Ive become a constructive critic of the mental health field and found that these ideas already existed on the fringes. They continue to gain momentum and Im excited to advocate for them.

Recovering from mental illness isnt easy, but it is relatively straightforward and its not hopeless. Id like to share my story to illustrate how the basic idea can be put into practice by anyone. Recovery is adapting to how your brain works. You accept how it works, observing what makes it worse or better, and learn to navigate the triggers and symptoms you experience. As you do things differently, these corrective experiences begin to undo the negative beliefs you have internalized. Its a long haul and takes commitment, but can lead to real and lasting returns. In many ways it isnt significantly different from the formula that the anonymous groups use to overcome addiction.

My story may help illustrate this. It starts with two diagnoses: ADHD and Borderline Personality Disorder. They ran my life ragged and by 24 I was lost, hopeless and desperate. But over the next few years I addressed my attention problems, paralyzing anxiety and complete inability to love myself.

I grew up in an affluent, happy home and community. But nothing seemed to work out for me from the very beginning. I learned that I had ADHD. I couldnt control myself, and was always told that I should be able to calm down, take no for an answer, and be patient. But inside, I knew I couldnt do these things. My parents yelled at me, my sister and her friends made fun of me. I was kicked out of preschool; they called me spaz throughout grade school. I found that I was willing to do anything for approval. I figured out later that approval, and the acceptance it implied, was the single most important thing in the world to me and that Id do anything for it. This is known as Borderline Personality Disorder. As I entered high school I stopped showing pain on the outside. I learned how destructive it was for me to let it out, so I swallowed it, doing anything to appear normal and letting the raging pain crush my spirit. This led to a diagnosis of depression. Of course, it was far more complicated than that and being told that this was just a chemical problem was deeply invalidating.

Upon finishing college there was so much noise in my head that I couldnt hear anything else. I discover...

20:02

Stigmatizing Language in Medical Records Affects Patient Care Mad In America

From Medical Xpress: A recent study found that the language used in a patients chart notes may affect how well that patient is treated, and how aggressively their pain is managed, for years to come.

Mary Catherine Beach, M.D., M.P.H., designed the study to determine whether the language and descriptions used in patient records can perpetuate bias among physicians. More than 400 physicians-in-trainingmedical students and residentswere presented with one of two vignettes about a hypothetical patient, a 28-year-old man with sickle cell disease and chronic hip pain.

While the vignettes contained medically identical information, one used neutral language to describe the patient and his condition, while the other vignette contained nonessential language that implied various value judgements.

Beach and her research colleagues found that physicians-in-training who read the stigmatizing patient chart notes were significantly more likely to have a negative attitude toward the patient than those who read the chart containing more neutral language.

Article 

20:01

The Sound of Madness Mad In America

From Harpers Magazine: People who hear positive, encouraging voices often seen as spiritual guides or messages and people diagnosed with schizophrenia are usually thought of as two completely distinct groups. However, several prominent European scientists argue that all auditory hallucinations exist on what they call the psychotic continuum; it is peoples responses to their voices, not the presence of voices themselves, that influence psychological well-being and functioning.

And yet one of the new ideas in psychiatric research is that these two seemingly distinct types of voice hearing might be related. A group of highly respected, mostly European scientistsamong them Jim van Os in Maastricht, the Netherlands, and Charles Fernyhough in Durham, Englandhave started to argue for the maverick idea that all auditory hallucinations exist on what they call the psychotic continuum. In other words, voices heard by healthy people are simply less severe manifestations of those heard by the mentally ill. These scientists suggest that hearing voices is like experiencing sadness. Some people are clearly sadder than others, and terrible sadness may require hospital care. But there is nothing inherently abnormal about sadness itself. Van Os, Fernyhough, and others have started to ask whether healthy people who hear voices frequently, like Sarah, somehow learned early on to manage their unusual perceptions and so never spiraled into mental illness. They believe that the voices of madness could be softened, if we could only teach people to harness them.

Article 

20:00

Universal Flu Shot AGE OF AUTISM

By Teresa Conrick Is this the answer to the issue of flu? Leave us a comment and share your thoughts. From Scientific American: Key facts - - If all goes according to plan, the annual flu shot protects about 60...

19:59

Use of Restraints in Schools Up AGE OF AUTISM

By Anne Dachel On May 17, CBS5 in Scottsdale, AZ aired the story, Family of autistic student alleges assault, cover-up during use of restraints at school For parents of children disabled with autism, there are lots of worries, especially when...

14:15

Dietary fiber confers protection against influenza. GreenMedInfo

PMID:  Immunity. 2018 May 15 ;48(5):992-1005.e8. PMID: 29768180 Abstract Title:  Dietary Fiber Confers Protection against Flu by Shaping Ly6cPatrolling Monocyte Hematopoiesis and CD8T Cell Metabolism. Abstract:  Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fermentable dietary fiber increased survival of influenza-infected mice through two complementary mechanisms. High-fiber diet (HFD)-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6cpatrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways. Blunted CXCL1 production reduced neutrophil recruitment to the airways, thus limiting tissue immunopathology during infection. In parallel, diet-derived SCFAs boosted CD8T cell effector function by enhancing cellular metabolism. Hence, dietary fermentable fiber and SCFAs set an immune equilibrium, balancing innate and adaptive immunity so as to promote the resolution of influenza infection while preventing immune-associated pathology.

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13:50

Glycyrrhizin suppresses the growth of human NSCLC cell line HCC827. GreenMedInfo

PMID:  Biomed Res Int. 2018 ;2018:6916797. Epub 2018 Jan 15. PMID: 29568761 Abstract Title:  Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level. Abstract:  Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cellsand tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.

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13:37

Glycyrrhizin ameliorates atopic dermatitis-like symptoms. GreenMedInfo

PMID:  Int Immunopharmacol. 2018 Apr 24 ;60:9-17. Epub 2018 Apr 24. PMID: 29702284 Abstract Title:  Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1. Abstract:  Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease prevalent worldwide. This study investigated the effects of glycyrrhizin, an extract of licorice root, on the well-established model of 2,4-dinitrochlorobenzene-induced AD-like symptoms in mice. The severity of dermatitis, histopathological changes, serum IgE levels, changes in expression of high-mobility group box 1 (HMGB1), the receptor for advanced glycation end products (RAGE), nuclear factor (NF)-B and inflammatory cytokines were evaluated. Treatment with glycyrrhizin inhibited the HMGB1 signaling cascade and ameliorated the symptoms of AD. Furthermore, in an in vitro study, the expression of RAGE was detected in a mouse mast cell line, P815 cells, and rmHMGB1 was found to be a potent inducer of mast cell activation by increasing Cainflux, upregulating the CD117 and activating NF-B signaling; these effects were also inhibited by glycyrrhizin. These findings implicate HMGB1 in the pathogenesis of AD and suggest that GL could be an effective therapeutic approach for cutaneous inflammation.

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13:24

Glycyrrhizin may be used as an effective therapeutic agent against osteoporosis and bone resorption. GreenMedInfo

PMID:  Calcif Tissue Int. 2018 May 2. Epub 2018 May 2. PMID: 29721581 Abstract Title:  Glycyrrhizin Suppresses RANKL-Induced Osteoclastogenesis and Oxidative Stress Through Inhibiting NF-B and MAPK and Activating AMPK/Nrf2. Abstract:  The treatment for osteoporosis involves inhibiting bone resorption and osteoclastogenesis. Glycyrrhizin (GLY) is a triterpenoid saponin glycoside known to be as the most medically efficacious component of the licorice plant. It has strong anti-inflammatory, antioxidant, and antitumor properties. We investigated the effect of GLY on osteoclastogenesis, bone resorption, and intracellular oxidative stress and its molecular mechanisms. In vitro osteoclastogenesis assays were performed using bone marrow monocytes with and without glycyrrhizin. We also evaluated the effects of glycyrrhizin on the secretion of TNF-, IL-1, and IL-6 in LPS-stimulated RAW 264.7 cells using ELISA. The effects of glycyrrhizin on the expression of osteoclast-related genes, such as Nfatc1, c-fos, Trap, and cathepsin K (CK), were investigated by RT-PCR. Intracellular reactive oxygen species (ROS) were detected in receptor activator of nuclear factor kappa- ligand (RANKL)-stimulated osteoclasts in the presence and absence of glycyrrhizin. During the inhibition of osteoclastogenesis by glycyrrhizin, phosphorylation of AMPK, Nrf2, NF-B, and MAPK was analyzed using western blotting. Our results showed that glycyrrhizin significantly inhibited RANKL-induced osteoclastogenesis, downregulated the expression of NFATc1, c-fos, TRAP, CK, DC-STAMP, and OSCAR, and inhibited p65, p38, and JNK. Glycyrrhizin was found to significantly decrease the secretion of inflammatory cytokines (TNF-, IL-1, and IL-6). Additionally, glycyrrhizin reduced the formation of ROS in osteoclasts by inducing AMPK phosphorylation and nuclear transfer of NRF2, resulting in an upregulation of antioxidant enzymes, such as HO-1, NQO-1, and GCLC. In summary, we found that glycyrrhizin inhibited RANKL-induced osteoclastogenesis. It was also indicated that glycyrrhizin could reduce oxidative stress by inhibiting the MAPK and NF-B pathways and activating the AMPK/NRF2 signaling. Therefore, glycyrrhizin may be used as an effective therapeutic agent against osteoporosis and bone resorption.

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13:13

Glycyrrhizin may act as a promising therapeutic avenue for the treatment of inflammatory pain. GreenMedInfo

PMID:  Exp Cell Res. 2018 May 12. Epub 2018 May 12. PMID: 29763588 Abstract Title:  Glycyrrhizin ameliorates inflammatory pain by inhibiting microglial activation-mediated inflammatory response via blockage of the HMGB1-TLR4-NF-kB pathway. Abstract:  Chronic inflammatory pain is a severe clinical problem that greatly affects patients' quality of life and causes huge economic burden. Microglia-mediated neuroinflammation exerts critical roles in the pathogenic progression of inflammatory pain. Recent evidence corroborates the anti-inflammatory and neuroprotective efficacy of glycyrrhizin; however, its function in inflammatory pain remains poorly elucidated. In the present study, glycyrrhizin suppressed LPS-induced activation of microglial cell BV2 by inhibiting NO production and expression of microglial marker IBA-1. Intriguingly, LPS-induced high expression and generation of inflammatory cytokines (i.e., IL-6, TNF- and IL-1) was notably reversed by glycyrrhizin pre-treatment. Mechanistic analysis confirmed that high expression of high-mobility group box 1 (HMGB1) in LPS-activated microglia was inhibited following glycyrrhizin. More importantly, restoring HMGB1 expression by recombinant adenovirus vector of Ad-HMGB1 counteracted glycyrrhizin-restrained inflammatory response in microglia upon LPS stimulation. Furthermore, glycyrrhizin dampened the activation of subsequent TLR4-NF-B pathway in LPS-stimulated microglia, which was abrogated by HMGB1 elevation. Furthermore, blocking this pathway by si-TLR4 transfection reversed the effects of HMGB1 overexpression on the inhibitor roles of glycyrrhizin in microglia-triggered inflammation. Additionally, glycyrrhizin administration also alleviated CFA-evoked mechanical allodynia and thermal hyperalgesia in inflammatory pain model of mice, concomitantwith suppression in inflammatory response and microglial activation. Simultaneously, elevation of HMGB1, TLR4 and p65-NF-B protein expression induced by CFA injection was also abrogated after glycyrrhizin. Accordingly, this study reveal that glycyrrhizin may act as a promising therapeutic avenuefor the treatment of inflammatory pain.

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12:54

Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats. GreenMedInfo

PMID:  Histol Histopathol. 2017 Aug ;32(8):851-860. Epub 2016 Dec 14. PMID: 27966208 Abstract Title:  Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats. Abstract:  Puerarin and zinc play a key role in preventing osteoporotic-related bone loss. Previous research on puerarin or zinc mainly focused on the anti-osteoporotic effects of long bone. However, it is obscure for puerarin or zinc to prevent mandibular osteoporosis. Here, we explore the effects on additive coadministration of puerarin and zinc on preventing mandibular bone loss in ovariectomized rats, and evaluate the underlying mechanisms ex vivo. Rats were ovariectomized and administrated puerarin, zinc or both. After 12 weeks, bone mineral density (BMD) and histomorphometry of mandibles were measured by micro-CT. The mechanical properties were determined using a three-point bending test. Then, osteogenic differentiation of primary bone marrow stromal cells (BMSCs) and osteoclastogenesis of bone marrow mononuclear were performed ex vivo. The culture supernatant and serum level of bone biochemical markers including osteoprotegerin (OPG), osteopontin (OPN), receptor activator of nuclear factor (NF)-B ligand (RANKL), and tartrate-resistant acid phosphatase (TRAP) were detected by ELISA. Culture supernatant and serum levels of calcium were measured using a Plasma Emission Spectrometer. One-way ANOVA was used for statistical analyses. The results showed that administration of puerarin plus zincprevented the decrease in mandibular BMD and bone morphometrical parameters more effectively than single use of puerarin or zinc (p

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12:32

Puerarin alleviates cognitive impairment and tau hyperphosphorylation. GreenMedInfo

PMID:  Zhongguo Zhong Yao Za Zhi. 2016 Sep ;41(17):3285-3289. PMID: 28920384 Abstract Title:  [Puerarin alleviates cognitive impairment and tau hyperphosphorylation in APP/PS1 transgenic mice]. Abstract:  To observe the effect of puerarin on learning and memory function and tau phosphorylation in APP/PS1 transgenic mice, drugs were administered to 3-month old APP/PS1 transgenic mice. Learning and memory function of mice were assessed by Morris water maze test 3 months after treatment. Animals were decapitated after behavioral test. The levels of A were detected by ELISA, the expression of protein [tau, phosphorylated tau, GSK3 and p-GSK3(Ser9)] were assessed by Western blot. Morris water maze test showed that the escape latency of APP/PS1 double transgenic mice was significantly longer than that of the normal control group, and the residence time of the original quadrant was significantly shorter. The escape latency of puerarin group was significantly shorter and the residence time of the original quadrant was prolonged compared with the model group. Compared with the normal control group, the levels of A in the cortex of APP/PS1 transgenic mice were increased, the expression of phosphorylated tau was significantly increased, and the expression of phosphorylated GSK3(Ser9) protein was decreased. Treatment with puerarin, the latency of APP/PS1 transgenic mice was significantly reduced, the level of A was decreased, theexpression of phosphorylated tau was significantly decreased, and the expression of phosphorylated GSK3(Ser9) protein was increased. Puerarin improves the learning and memory impairment by reducing the formation of A, activating the GSK3 signaling pathway, inhibiting the phosphorylation of tau in APP/PS1 double transgenic mice.

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12:25

Puerarin increases the chemosensitivity of hepatocellular carcinoma cells. GreenMedInfo

PMID:  Oncol Lett. 2017 Sep ;14(3):3006-3010. Epub 2017 Jul 5. PMID: 28928838 Abstract Title:  Puerarin increases the chemosensitivity of hepatocellular carcinoma cells. Abstract:  The present study investigated the effect of puerarin (Pu) on the sensitivity of HepG2 human hepatocellular carcinoma (HCC) cells to chemotherapeutic drugs to determine the possible mechanism. HepG2 cells were treated with different concentrations of Pu and cisplatin (CDDP), alone or in combination. MTT assay was used to determine the inhibitory effects of the different drugs on HepG2 cells. Cell morphology was observed by inverted microscopy. The expression of B-cell lymphoma 2 (Bcl-2) and Bax protein was measured by western blot analysis. Pu and CDDP, alone or in combination, inhibited the proliferation of HepG2 cells. The inhibitory effect of CDDP combined with Pu on HepG2 cells was significantly higher than that of the single drug treatments (p

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12:12

Puerarin may exert protective effects against Alzheimer's disease. GreenMedInfo

PMID:  Mol Med Rep. 2017 Dec ;16(6):9081-9085. Epub 2017 Oct 3. PMID: 28990074 Abstract Title:  Puerarin inhibitsamyloid peptide 142induced tau hyperphosphorylation via the Wnt/catenin signaling pathway. Abstract:  Excessive tau protein phosphorylation is important in the pathogenesis and early abnormal signal transduction of Alzheimer's disease. Excessive phosphorylation of microtubules is associated with tau accumulation, which induces the formation of neurofibrillary tangles in neurons, leading to synaptic damage and ultimately, neurodegeneration. The present study aimed to investigate the possible mechanism underlying the inhibitory effects of puerarin onamyloid peptide (A)142induced tau protein hyperphosphorylation in SHSY5Y cells. Following various treatments, the viability of SHSY5Y cells was determined using the MTT assay, and cell morphology was observed under an inverted fluorescence microscope. Western blotting was used todetect tau phosphorylation, and the protein expression levels of glycogen synthase kinase (GSK)3, phosphorylated (p)GSK3 (Ser9), catenin and cyclin D1, which are the key factors mediating the Wnt/catenin signaling pathway in SHSY5Y cells. The results demonstrated that puerarin reversed the A142induced decrease in SHSY5Y cell viability. In addition, puerarin inhibited the degree of A142induced tau phosphorylation at Ser396, Ser199 and Thr231 in SHSY5Y cells, and reduced the expression of GSK3 by increasing the expression of pGSK3 (Ser9). Furthermore, puerarin increased the protein expression levels of catenin and cyclin D1, which are key factors involved in the Wnt/catenin signaling pathway. The results of the present study demonstrated that puerarin may attenuate A142induced tau hyperphosphorylation in SHSY5Y cells, by inhibiting the expression of GSK3 and activating the Wnt/catenin signaling pathway; therefore, puerarin may exert protective effects against Alzheimer's disease.

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12:01

Puerarin possessed certain anticoagulation and may be a potential novel therapeutic drug for thrombosis in coronary artery disease. GreenMedInfo

PMID:  Life Sci. 2017 Dec 15 ;191:115-121. Epub 2017 Oct 14. PMID: 29037842 Abstract Title:  Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-B. Abstract:  AIMS: The present study aimed to investigate whether puerarin regulated tissue factor (TF) expression induced by oxidative low-density lipoprotein (ox-LDL), an independent risk factor for atherosclerosis, and its mechanisms.MAIN METHODS: TF expression at the mRNA level was determined by reverse transcription-quantitative polymerase chain reaction, and its expression at the protein level, as well as other target proteins, was assessed by western blotting. Nitric oxide (NO) production was measured by a nitrate reduction method.KEY FINDINGS: Results demonstrated that treatment with ox-LDL (50mg/l) for 24h significantly increased (P

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11:13

A Mediterranean diet pattern may be one dietary strategy to reduce metabolic endotoxemia. GreenMedInfo

PMID:  Adv Nutr. 2018 May 1 ;9(3):193-206. PMID: 29767701 Abstract Title:  Microbiome-Mediated Effects of the Mediterranean Diet on Inflammation. Abstract:  The Mediterranean diet pattern is increasingly associated with improved metabolic health. Two mechanisms by which consuming a Mediterranean diet pattern may contribute to improved metabolic health are modulation of the gastrointestinal (GI) microbiota and reduction of metabolic endotoxemia. Metabolic endotoxemia, defined as a 2- to 3-fold increase in circulating levels of bacterial endotoxin, has been proposed as a cause of inflammation during metabolic dysfunction. As the largest source of endotoxins in the human body, the GI microbiota represents a crucial area for research on strategies for reducing endotoxemia. Diets high in saturated fat and low in fiber contribute to metabolic endotoxemia through several mechanisms, including changes in the GI microbiome and bacterial fermentation end products, intestinal physiology and barrier function, and enterohepatic circulation of bile acids. Thus, the Mediterranean diet pattern, rich in unsaturated fats and fiber, may be one dietary strategy to reduce metabolic endotoxemia. Preclinical studies have demonstrated the differential effects of dietary saturated and unsaturated fats on the microbiota and metabolic health, but human studies are lacking. The role of dietary fiber and the GI microbiome in metabolic endotoxemia is underinvestigated. Clinical research on the effects of different types of dietary fat and fiber on the GI microbiota and GI and systemic inflammation is necessary to determine efficacious dietary strategies for reducing metabolic endotoxemia, inflammation, and subsequent metabolic disease.

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10:59

Law Enforcement Raid Whole Food Co-op in Minnesota Who Sell Raw Milk REALfarmacy.com

Source: Law Enforcement Raid Whole Food Co-op in Minnesota Who Sell Raw Milk For more content like this visit REALfarmacy.com.

Authorities have shut down a south Minneapolis food distributor and seized thousands in goods after claiming that it has been illegally selling raw milk and meat products. From StarTribune: On May 3, health inspectors from the city, along with a Minneapolis police officer and an inspector for the Minnesota Department of Agriculture, executed a search warrant on the south Minneapolis property. []

Source: Law Enforcement Raid Whole Food Co-op in Minnesota Who Sell Raw Milk Learn more at REALfarmacy.com - Healthy News and Information.

10:19

A higher adherence to Mediterranean diet is associated with a lower risk of frailty in old people. GreenMedInfo

PMID:  J Nutr Health Aging. 2018 ;22(5):613-618. PMID: 29717762 Abstract Title:  Adherence to the Mediterranean Diet and the Risk of Frailty in Old People: A Systematic Review and Meta-Analysis. Abstract:  BACKGROUND: Frailty is a common geriatric syndrome in old people. It remains controversial whether Mediterranean diet could prevent old people from developing into frailty. The aim of this study is to summarize the relevant studies and assess the effectiveness of adherence to Mediterranean diet on frailty in old people.METHOD: A systematic search of MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials was conducted to identify all relevant studies up to Oct 2017. We included studies regarding the associations between adherence to Mediterranean diet and risk of frailty among elders. A meta-analysis was performed to explore the effects of Mediterranean diet on frailty.RESULTS: Six studies matched the inclusion criteria, of which five were prospective and one was cross-sectional. A total of 10,210 participants from the five prospective cohort studies were included to perform the meta-analyses. In comparison with lowest adherence to Mediterranean diet, elders with highest adherence to Mediterranean diet were significantly associated with lower risk of frailty in the future (RR= 0.56, 95% CI=0.36-0.89, p=0.015). Furthermore, the pooled estimates from four studies performed among participants in western countries (European and North American) showed that higher adherence to Mediterranean diet was associated with a 52% reduced risk of frailty (RR= 0.48, 95% CI=0.32-0.72, p

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10:05

A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome. GreenMedInfo

PMID:  Br J Nutr. 2018 May ;119(10):1168-1176. PMID: 29759108 Abstract Title:  A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome. Abstract:  The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malm Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL- and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin). Patterns were examined in relation to change in cardio-metabolic traits and iMetS in subjects who were re-examined after 167 years (n 2704). Two dietary patterns('Western' and 'Drinker') were retained and explained 32 % of the variation in response variables. The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL atfollow-up. After adjustment for potential confounders, the 'Western' dietary pattern was associated with higher risk of iMetS (hazard ratio Q4 v. Q1: 147; 95 % CI 123, 177; P trend=1510-5). The 'Drinker' dietary pattern primarily explained variation in HDL and was not associated with iMetS. In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables and high-fibre foods is associated with detrimental effects on cardio-metabolic health.

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09:55

Puerarin can improve LPS-induced contractile dysfunction in isolated heart and inhibit LPS-stimulated myocardial TNF- production. GreenMedInfo

PMID:  Pak J Pharm Sci. 2017 Jul ;30(4):1195-1202. PMID: 29039314 Abstract Title:  Effects of puerarin on lipopolysaccharide-induced myocardial dysfunction in isolated rat hearts. Abstract:  Myocardial dysfunction is a serious complication induced by sepsis. Puerarin is an oriental medicine that possesses therapeutic benefits for cardiovascular diseases. The aim of this study was to evaluate the anti-myocardial dysfunction effects of puerarin in isolated rat hearts induced by lipopolysaccharide- and compare the myocardial protective effects between the different concentrations of puerarin. Isolated hearts were attached to a Langendorff apparatus and perfused with lipopolysaccharide (LPS) and different concentrations of puerarin. The hemodynamic parameters of heart rate (HR), left ventricular end systolic pressure [LVESP], +dp/dt, and -dp/dtwere recorded. The biochemical indexes of lactic dehydrogenase (LDH), tumor necrosis factor alpha (TNF-), and creatine kinase (CK) in the coronary effluent were measured at 40, 90, and 120 min of perfusion. TNF- in myocardial tissues was measured after perfusion was completed. As a result, puerarin (0.24 mmol/L-0.48 mmol/L) significantly increased LVESP, +dp/dt, -dp/dt, and HR in isolated rat hearts that were declined by LPS during perfusion periods. Puerarin could protect against increased LDH, CK, and TNF- in coronary effluent of isolated rat hearts by LPS during perfusion periods. Treatment of 0.48 mmol/L puerarin significantly decreased the TNF- in coronary effluent of isolated rat hearts compared with the treatment of 0.12 and 0.24 mmol/L puerarin, but the TNF- values were not reverted to baseline levels. However, the difference of TNF- in myocardial tissue in the three puerarin-combined groups was statistically significant. This study confirms that puerarin can improve LPS-induced contractile dysfunction in isolated heart and inhibit LPS-stimulated myocardial TNF- production.

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09:44

Puerarin may be a potential cardioprotective agent for use in the clinical treatment of cardiomyopathy triggered by daunorubicin. GreenMedInfo

PMID:  Int J Mol Med. 2017 Dec ;40(6):1889-1894. Epub 2017 Oct 12. PMID: 29039532 Abstract Title:  Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. Abstract:  Puerarin extracted from Radix Puerariae is well known for its pharmacological effects, including antioxidant, antiinflammatory, neuroprotective and cardioprotective properties. In this study, we aimed to investigate the effects of puerarin on the daunorubicin (DNR)-induced apoptosis of H9c2 cells and to elucidate the potential mechanisms involved. MTT assay and flow cytometry were performed to evaluate cell cytotoxicity and apoptosis, respectively. Western blot analysis was used to assess changes in the expression levels of proteins, including caspase-3, Akt and phosphorylated Akt (p-Akt). Ratiometric imaging of intracellular calcium (Ca2+) using cells loaded with Fura-2 was also carried out. Our results revealed that puerarin pre-treatment protected the H9c2 cells against DNR-induced cytotoxicity by inhibiting cell apoptosis, which was also confirmed by the decrease in the expression of cleaved caspase-3.Additionally, p-Akt activation was associated with the suppressive effects of puerarin. Following pre-treatment with puerarin, the extracellular Ca2+ influx was restrained and this resulted in a reduction in the intracellular Ca2+ levels; these effects were abrogated by LY294002 [an inhibitor ofphosphatidylinositol 3-kinase (PI3K)]. The inhibition of Ca2+ influx suggested that the PI3K/Akt signaling pathway participated in the suppressive effects of puerarin against H9c2 cell apoptosis. Taken togher, our findings demonstrate that puerarin attenuates the DNR-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx, suggesting that puerarin may be a potential cardioprotective agent for use in the clinical treatment of cardiomyopathy triggered by DNR.

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09:36

Puerarin combined with conventional therapy on ischemic stroke had beneficial effects. GreenMedInfo

PMID:  Exp Ther Med. 2017 Oct ;14(4):2943-2946. Epub 2017 Aug 11. PMID: 29042907 Abstract Title:  Effects of puerarin combined with conventional therapy on ischemic stroke. Abstract:  This study evaluated the use of conventional therapy combined with puerarin on ischemic stroke. Eighty patients with ischemic stroke admitted to Tangshan Gongren Hospital from March 2014 to September 2015 were randomly divided into two groups. The control group was treated with conventional therapy. The observation group was treated with an additional puerarin injection of 400 mg/day. The patients in both groups were examined for clinical neurological signs and symptoms. The levels of biochemical markers as well as changes in hemorheology were measured after the intervention and compared among the groups. Our results indicate that the language expression was significantly better in the observation group after the intervention (p

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09:23

Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats. GreenMedInfo

PMID:  Eur J Pharmacol. 2018 Jan 5 ;818:115-123. Epub 2017 Oct 20. PMID: 29061371 Abstract Title:  Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving-opioid receptor. Abstract:  Puerarin, a major active isoflavone extracted from the root of Pueraria lobate, significantly increases plasma-endorphin and insulin levels and improves impaired insulin signaling in diabetic animals. However, the target tissues and underlying mechanisms in and through which puerarin functions to ameliorating insulin resistance remains largely unclear. In this study, we showed that puerarin enhanced -opioid receptor expression and phosphorylation, and increased insulin-stimulated glucose transporter 4 translocation to the plasma membrane in the skeletal muscle of diabetic rats, which were recaptured by a direct application of puerarin in the palmitate-induced insulin-resistant L6 myotubes. Naloxone, an antagonist of -opioid receptor, blocked these functions of puerarin. No -endorphin was detected either in the muscle of diabetic rats or in the palmitate-induced insulin-resistant L6 cells. Furthermore, we presented the evidence to show the interaction between -opioid receptor and insulin receptor substrate 1 in the muscle tissues and cells. These results suggested that puerarin improved insulin sensitivity in the skeletal muscle at least in part by its local effects involving -opioid receptor function.

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09:20

Exercise and puerarin intervention can really play a role in the prevention and treatment of diabetes. GreenMedInfo

PMID:  Pak J Pharm Sci. 2017 Sep ;30(5(Special)):1899-1903. PMID: 29084664 Abstract Title:  Effect of puerarin on type II diabetes mellitus with orthopaedic footwear. Abstract:  In recent years, the antioxidant efficacy of puerarin has been recognized. However, there is less research on Puerarin used in diabetes. This paper analyzes the effect of puerarin on type II diabetes mellitus induced by streptozotocin combined with orthopaedic footwear. In this study, 80 Sprague Dawley (SD) rats were fed with high fat and high sucrose diet for one month, and 1% streptozotocin (STZ) was used to induce type II diabetes mellitus. After 6 weeks aerobic exercise and puerarin intervention in rats, the effect of aerobic exercise and puerarin intervention on antioxidant ability in diabetic rats was investigated. The results showed that aerobic exercise and puerarin intervention can improve the insulin resistance in rats. Meanwhile, the annual incidence of foot ulcers in diabetic patients is 2%, while orthopaedic footwear can reduce the probability of diabetic foot ulcers. In general, exercise and puerarin intervention can really play a role in the prevention and treatment of diabetes, such as improving the metabolic status of diabetic patients and reducing their dependence on drugs.

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07:23

Global Glyphosate Herbicide Study Shows Adverse Health Effects on Children at Safe Dose Health Impact News

Roundup

Global Glyphosate Study pilot phase shows adverse health effects at safe dose

by GMWatch.org

Effects found on sexual development, genotoxicity, and the intestinal microbiome

Glyphosate-based herbicide caused adverse health effects in rats at a dose claimed to be safe by regulators, according to a new study. Glyphosate herbicides are used on the vast majority of all GM crops worldwide.

The study used the US Environmental Protection Agencys acceptable daily dietary exposure level of glyphosate(1) 1.75 mg per kg of bodyweight per day. The same concentration was given to the rats daily over a 3-month period.

The study was focused on the newborn, infancy and adolescence phases of life. The results reveal that glyphosate-based herbicide (GBH) was able to alter certain important biological parameters, mainly relating to sexual development, genotoxicity, and the intestinal microbiome.

The effects occurred at a dose deemed safe by regulators to ingest on a daily basis over a long-term period. In human-equivalent terms the dosing period corresponded to the period from the embryo stage to 18 years of age.

Results in detail

The results showed an alteration in some sexual development parameters in rats treated with GBH, especially in females. Moreover, rats treated with GBH presented statistically significant changes of the intestinal microbiome in particular during development.

Concerning genotoxicity, a statistically significant increase was observed in micronuclei in rats treated with GBH, especially in the first part of life.

Rats treated with pure glyphosate or its formulation presented similar levels in urine of glyphosate and its principal metabolite (AMPA), thus showing no significant difference in the absorption and excretion of glyphosate among the two treatment groups, but suggesting a bioaccumulation effect of glyphosate that was proportional to the length of treatment.

The study was conducted at the Ramazzini Institute, Bologna, Italy. In over 40 years of activity, the institute has studied more than 200 compounds fro m the general and occupational environment and many of its results have provided a solid scientific base forregulating and limiting the exposure of a number of substances. Examples include vinyl chloride, benzene, formaldehyde, trichloroethylene and mancozeb.

Comments from scientists

Commenting on t...

07:10

10 Foods Made Out of Plastic, Pesticides, and Cancer-Causing-Chemicals: Made In China Healthy Holistic Living

By Abbey Ryan We all know that McDonalds, Taco Bell, Burger King, and other fast food chains all offer snacks, meals, and desserts that are, lets be honest, not 100%-real food. How else could they make their menus so cheap? But did you know that China is dishing out food item after food item that... View Article

The post 10 Foods Made Out of Plastic, Pesticides, and Cancer-Causing-Chemicals: Made In China appeared first on Healthy Holistic Living.

06:34

CNN: Parasites and bacteria may be lurking in hotel pools, hot tubs, CDC warns Health Nut News

A new government report has found that parasites and bacteria in hotel pools and hot tubs were responsible for nearly a third of all disease outbreaks in the United States linked to chlorinated or treated water between 2000 and 2014. During that 15-year period, a total of 493 outbreaks linked to treated recreational water were reported []

The post CNN: Parasites and bacteria may be lurking in hotel pools, hot tubs, CDC warns appeared first on Health Nut News.

06:04

CNN: Almost half of US families cant afford basics like rent and food Health Nut News

Although our economy isnt exactly stalled, the middle class is continuing to disappear and many Americans are still struggling to afford the basics. Last week the United Way ALICE (Asset Limited, Income Constrained, Employed) Project released a study which found that nearly 51 million households dont earn enough money to afford a monthly budget that []

The post CNN: Almost half of US families cant afford basics like rent and food appeared first on Health Nut News.

05:49

As Mercks Gardasil U.S. Sales Decline Profits Continue to Increase as Vaccine is Launched in China Health Impact News

Gardasil-vaccine-China image

Health Impact News Editor Comments

The pharmaceutical marketing trade publication, Fierce Pharma, announced this month (May 2018) that Merck has beat Wall Street expectations for their Gardasil vaccine sales during the first quarter of 2018, achieving 24% growth with $660 million for the HPV vaccine.

The report notes that sales in the U.S. are declining, attributing the decline in sales to the CDC decision to reduce their recommendation of the Gardasil vaccine to be only two doses, instead of three.

Nothing is mentioned about declining public opinion regarding Gardasil, nor the numerous lawsuits against the company outside the U.S.

The increase in sales for Gardasil is attributed to their entrance into the China market.

Gardasil remains Mercks top vaccine by sales.

As we just reported in an article published at The Vaccine Reaction, U.S. taxpayers subsidized the development of Gardasil, and continue to fund their marketing of the vaccine. See:

U.S. Taxpayer Funds Used To Develop and Market Mercks Gardasil Vaccine Global Empire

Boosted by China launch, Mercks Gardasil turns in a big first-quarter performance

by Eric Sagonowsky
FiercePharma

Excerpts:

Even as Mercks Gardasil sales suffer in the U.S. from the CDCs decision to implement a two-dose regimen, the HPV vaccine franchise posted strong growth in the first quarter as a China launch begins to pay off.

Globally, Gardasil and Gardasil 9 revenues grew 24% in the first quarter to $660 million, pushing Mercks vaccine unit to...

05:25

As Mercks Gardasil U.S. Sales Decline Profits Continue to Increase as Vaccine is Launched in China Vaccine Impact

Gardasil-vaccine-China image

Health Impact News Editor Comments

The pharmaceutical marketing trade publication, Fierce Pharma, announced this month (May 2018) that Merck has beat Wall Street expectations for their Gardasil vaccine sales during the first quarter of 2018, achieving 24% growth with $660 million for the HPV vaccine.

The report notes that sales in the U.S. are declining, attributing the decline in sales to the CDC decision to reduce their recommendation of the Gardasil vaccine to be only two doses, instead of three.

Nothing is mentioned about declining public opinion regarding Gardasil, nor the numerous lawsuits against the company outside the U.S.

The increase in sales for Gardasil is attributed to their entrance into the China market.

Gardasil remains Mercks top vaccine by sales.

As we just reported in an article published at The Vaccine Reaction, U.S. taxpayers subsidized the development of Gardasil, and continue to fund their marketing of the vaccine. See:

U.S. Taxpayer Funds Used To Develop and Market Mercks Gardasil Vaccine Global Empire

Boosted by China launch, Mercks Gardasil turns in a big first-quarter performance

by Eric Sagonowsky
FiercePharma

Excerpts:

Even as Mercks Gardasil sales suffer in the U.S. from the CDCs decision to implement a two-dose regimen, the HPV vaccine franchise posted strong growth in the first quarter as a China launch begins to pay off.

Globally, Gardasil and Gardasil 9 revenues grew 24% in the first quarter to $660 million, pushing Mercks vaccine unit to mor...

04:54

Teacher Had Students Drown Live Raccoons In Class Natural Blaze

Teacher Had Students Drown Live Raccoons In Front of a Class

By Brandon TurbevilleNatural Blaze

Teacher Accused of Having Students Drown Live Raccoons and an Opossum in Class

Only a month after a teacher in Idaho teacher allegedly fed a live puppy to a snapping turtle in front of his class, yet another public school teacher has caused a controversy by torturing an animal to death in front of students by slowly drowning them in a garbage can full of water. This time, the psychopath in question resides in Florida and the incident at Forest High School in Marion County was caught on camera. The victims were two raccoons and an opossum.

An investigation is now underway after a student brought home a video recording of the incident that the students were forced to participate in. The students mother said that the student came home in tears over being forced to take part in the murder.

...

04:53

U.S. Taxpayer Funds Used To Develop and Market Mercks Gardasil Vaccine Global Empire Health Impact News

NIH-CDC-Merck-Gardasil image

How NIH Uses U.S. Tax Dollars to Secure Profits for Vaccine Developers and Manufacturers

by The Vaccine Reaction Staff

It is no secret that huge conflicts of interest exist between vaccine promoters and vaccine makers.

Pediatrician and vaccine developer Paul Offit, for example, who is one of the nations leading promoters of mandatory use of government recommended vaccines, holds a $1.5 million research chair at Childrens Hospital in Philadelphia, funded in part by Merck.1

Julie Gerberding left her post as Director of the Centers for Disease Control and Prevention (CDC), where she oversaw the creation of national vaccine policies, to head Merck vaccines.2

Former Texas governor Rick Perry recommended state-wide inoculation of all 11- and 12-year-old girls with Mercks Gardasil vaccine after his chief of staff left to work at Merck.3 4

Just as disturbing are the millions of dollars that officials at the National Institutes of Health (NIH) dole out to academic institutions and vaccine manufacturers to improve vaccine technology, find new, lucrative markets and boost vaccine marketabilityfunctions that guarantee the profitability of corporations, but do not always ensure the well being of taxpayers, the public and patients.

Once upon a time, before passage of the Bayh-Dole Act by Congress in 1980 and the push for lucrative technology transfer business arrangements between federal agencies and for-profit corporations, inventions developed with federal funding were owned by the U.S. Government and not industry.

Today, taxpayer-supported research to develop new drugs and vaccines is voraciously patented by universities and drug companies for outsized Wall Street profits when the research rightfully belongs to taxpayers.5

HPV Vaccine  Using U.S. Taxpayer Funding to Develop and Market the Vaccine Globally

Development of the human papillomavirus (HPV) Gardasil and Cervarix vaccines is a case in point.

The initial research was funded by the NIH, National Cancer Institute, University of Rochester, Georgetown University and the University of Queensland, which licensed them to Merck and GlaxoSmithKline.6 7

In 2015, Merck made $1.9 billion on its Gardasil franchise.8

Soon, aggressive domestic and overseas ma...

04:34

More Opioid Crisis Cronyism The Alliance for Natural Health

One persons health care crisis is Big Pharmas golden opportunity.

From Stat News:

The White Houses national strategy to combat the opioid crisis, unveiled last week, would expand a particular kind of addiction treatment in federal criminal justice settings: a single drug, manufactured by a single company, with mixed views on the evidence regarding its use.

Federal prisons should facilitate naltrexone treatment and access to treatment to inmates as they transition out of incarceration, according to a fact sheet circulated by the administration. A White House spokesman later confirmed to STAT that the document referred specifically to naltrexone in its injectable form.

Comment: This is the very definition of crony capitalismwhen the government gets to pick winners and losers. Dont forget that the losers in this case are cheap, safe, and effective natural remedies, where the government blocks access to information (like the benefits of vitamin D for the flu) or bans access altogether (like CBD oil for pain).

04:32

U.S. Taxpayer Funds Used To Develop and Market Mercks Gardasil Vaccine Global Empire Vaccine Impact

NIH-CDC-Merck-Gardasil image

How NIH Uses U.S. Tax Dollars to Secure Profits for Vaccine Developers and Manufacturers

by The Vaccine Reaction Staff

It is no secret that huge conflicts of interest exist between vaccine promoters and vaccine makers.

Pediatrician and vaccine developer Paul Offit, for example, who is one of the nations leading promoters of mandatory use of government recommended vaccines, holds a $1.5 million research chair at Childrens Hospital in Philadelphia, funded in part by Merck.1

Julie Gerberding left her post as Director of the Centers for Disease Control and Prevention (CDC), where she oversaw the creation of national vaccine policies, to head Merck vaccines.2

Former Texas governor Rick Perry recommended state-wide inoculation of all 11- and 12-year-old girls with Mercks Gardasil vaccine after his chief of staff left to work at Merck.3 4

Just as disturbing are the millions of dollars that officials at the National Institutes of Health (NIH) dole out to academic institutions and vaccine manufacturers to improve vaccine technology, find new, lucrative markets and boost vaccine marketabilityfunctions that guarantee the profitability of corporations, but do not always ensure the well being of taxpayers, the public and patients.

Once upon a time, before passage of the Bayh-Dole Act by Congress in 1980 and the push for lucrative technology transfer business arrangements between federal agencies and for-profit corporations, inventions developed with federal funding were owned by the U.S. Government and not industry.

Today, taxpayer-supported research to develop new drugs and vaccines is voraciously patented by universities and drug companies for outsized Wall Street profits when the research rightfully belongs to taxpayers.5

HPV Vaccine  Using U.S. Taxpayer Funding to Develop and Market the Vaccine Globally

Development of the human papillomavirus (HPV) Gardasil and Cervarix vaccines is a case in point.

The initial research was funded by the NIH, National Cancer Institute, University of Rochester, Georgetown University and the University of Queensland, which licensed them to Merck and GlaxoSmithKline.6 7

In 2015, Merck made $1.9 billion on its Gardasil franchise.8

Soon, aggressive domestic and overseas marke...

04:06

There Is Scientific Evidence That Clutter Causes Anxiety Healthy Holistic Living

There are two types of people in this world. The people who seem to thrive in a cluttered environment, and the people who need everything in pristine condition in order to focus. Which one are you?  Clutter is defined as a collection of things laying around in an untidy mass. Whether or not you feel... View Article

The post There Is Scientific Evidence That Clutter Causes Anxiety appeared first on Healthy Holistic Living.

04:04

8 Important Signs That Your Body Is Stressed Healthy Holistic Living

One out of every three Americans adult are living with extreme stress and a whooping 48 percent of Americans believe that their stress has increased over the past five years (1). Studies show that stress causes more than half of Americans to have fights with the people around them; usually those who they love most (1). On average, adults rate... View Article

The post 8 Important Signs That Your Body Is Stressed appeared first on Healthy Holistic Living.

04:02

Hawaii Is Banning Certain Sunscreens. Heres Why. Healthy Holistic Living

Are you planning a visit to the beautiful state of Hawaii? Do you want to come home from your vacation looking like a sunburned tomato? No? Well, then you should do your research since Hawaii is banning certain sunscreens and you might end up getting yours confiscated (1). Protecting your skin from harmful sunrays is... View Article

The post Hawaii Is Banning Certain Sunscreens. Heres Why. appeared first on Healthy Holistic Living.

03:58

Neuroscientists Have Discovered A Song That Reduces Anxiety Healthy Holistic Living

Whether you have an anxiety disorder or not, feeling nervous, worried, or afraid are all common reactions to the many situations that life has to offer. Everyone has their own method of finding calm whether its yoga routines, spending time in nature, or maybe reading a book. One popular method that you may have tried,... View Article

The post Neuroscientists Have Discovered A Song That Reduces Anxiety appeared first on Healthy Holistic Living.

03:57

Doctors Urging People To Stop Taking Ibuprofen Immediately Healthy Holistic Living

By Kat Gl Do you suffer from nagging chronic pain such as headaches, neck pain, muscle pain or arthritis? Do you reach for good old ibuprofen to subside the pain? I am sure we all have a bottle in our medicine cabinets. Research is showing, however, that popping a few of the trusty pills may... View Article

The post Doctors Urging People To Stop Taking Ibuprofen Immediately appeared first on Healthy Holistic Living.

03:33

The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain. GreenMedInfo

PMID:  Metab Brain Dis. 2018 Feb ;33(1):167-175. Epub 2017 Nov 3. PMID: 29101599 Abstract Title:  The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain. Abstract:  Anxiety disorder is a serious and burdensome psychiatric illness that frequently turn into chronic clinical conditions. Puerarin have been shown to be effective in the therapy of depression. However, few studies are concerned about the anxiolytic-like effects of puerarin. The current study aimed to evaluate the anxiolytic-like effects of puerarin and its possible mechanism. To evaluate this, the behavioral tests, i.e. Vogel-type conflict test (VTCT), elevated plus-maze test (EPMT), and open-field test (OFT) were conducted. Data showed that similar to the positive-control drug sertraline (Ser) (15 mg/kg, i.g.), the anxiolytic-like effects were produced by puerarin (60 and 120 mg/kg, i.g.) in VTCT and EMPT respectively without affecting locomotor activity in OFT. Moreover, the present study also found that consistent with Ser, the levels of allopregnanolone and serotonin (5-HT) in the prefrontal cortex and hippocampus were increased by puerarin (60 and 120 mg/kg, i.g.), respectively. In summary, the present study indicated that puerarin exerted the anxiolytic-like effects, which maybe associated with normalization of 5-HT levels and biosynthesis of allopregnanolone in brain.

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03:27

Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353. GreenMedInfo

PMID:  Oncol Lett. 2017 Nov ;14(5):5585-5590. Epub 2017 Sep 6. PMID: 29113186 Abstract Title:  Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353 via inhibition of the PI3K/Akt signaling pathway. Abstract:  Chondrosarcoma is a malignant soft tissue sarcoma with poor prognosis. Puerarin has been demonstrated to possess anticancer properties; however, the effects of puerarin in human chondrosarcoma cells remain unknown. The present study aimed to investigate the anticancer effects of puerarin in SW1353 human chondrosarcoma cells. SW1353 cells were treated with increasing concentrations of puerarin for different durations. Cell viability was evaluated using MTT assays. Cell apoptosis rates were determined by flow cytometry. The activities of caspase-3 and caspase-9 were measured by enzymatic assay. The expression of RAC-alpha serine/threonine-protein kinase (Akt), phosphorylated-Akt, caspase-3 and apoptosis-associated proteins, including B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) were detected by western blotting. Puerarin significantly decreased cell viability and significantly induced apoptosis of SW1353 cells. In addition, puerarin significantly increased the enzymatic activities of caspase-3 and caspase-9. Puerarin treatment suppressed the expression of p-Akt and Bcl-2 but promoted the expression of Bax and cleaved caspase-3 in SW1353 cells. Notably, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abrogated the decreased phosphorylation of Akt, suggesting that the PI3K/Akt signaling pathway is involved in mediating the anticancer effects of puerarin. The data from the present study indicated that puerarin exhibits anticancer effects in SW1353 cells and may be a potential therapeutic drug for patients with chondrosarcoma.

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03:08

Research progress of puerarin and its derivatives on anti-inflammatory and anti-gout activities. GreenMedInfo

PMID:  Zhongguo Zhong Yao Za Zhi. 2017 Oct ;42(19):3703-3708. PMID: 29235282 Abstract Title:  [Research progress of puerarin and its derivatives on anti-inflammatory and anti-gout activities]. Abstract:  The research progress of puerarin and its derivatives in anti-inflammatory and anti-gout activities was reviewed in this paper. Puerarin possesses anti-inflammatory activity by affecting immunocyte, inflammation cytokines and signaling pathway. Puerarin also has anti-gout activity through inhibition of xanthine oxidase, promoting the excretion of uric acid to reduce serum uric acid level. Although its ability in reducing uric acid level was lower than that of allopurinol in clinical application, puerarin can also enhance the total antioxidant and free radical scavenging with stronger anti-inflammatory effect, so it will be a promising research direction to find new drugs with better anti-gout activity and less side effects by modifying the chemical structure of puerarin.

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03:01

Surgeon Reveals Why Texting Causes So Much Neck Stress Natural Blaze

By Anna Hunt

Texting can create so much neck stress, its like carrying four adult-size bowling balls on the cervical spine, reveals a report published in Surgical Technology International. Written by a spine surgeon, the study shows that tilting your head forward makes the head seem much heavier than it really is. This can have lasting degenerative effects on the neck.

Neck Stress from Texting

Adults spend on average 700 to 1,400 hours per year reading and texting on their smartphone. This jumps up to about 5,000 hours for an average teenager. All of this looking down at the smartphone results in hours upon hours of bad posture with lots of undue neck stress.

How much stress? Kenneth Hansraj, MD and Chief of Spine Surgery at the New York Spine Surgery and Rehabilitation Medicine, asked just that. Through a series of calculations, he found that the typical texting position can increase the weight of the head by 5 times.

The average head weighs about 10-12 pounds in the neutral position. But when we text, we do not hold our head in neutral. Typically, when were texting, the head starts tilting forward, and the shoulders slump forward, as well.

A 15-degree tilt of the head creates 27 pounds of stress on the neck. Increase this to 30 degrees, and this jumps up to 40 pounds.

When the head is tilted down 60 degrees, it creates 60 pounds of stress on the spine. This is the equivalent to an average 8 year old! Or four adult-size bowling balls.

...

02:50

Puerarin stimulates osteogenic differentiation and bone formation. GreenMedInfo

PMID:  Curr Mol Med. 2018 Mar 9 ;17(7):488-496. PMID: 29256352 Abstract Title:  Puerarin Stimulates Osteogenic Differentiation and Bone Formation Through the ERK1/2 and p38-MAPK Signaling Pathways. Abstract:  BACKGROUND: Osteoporosis is a world-wide health problem, which leads to decreased bone strength and increased susceptibility to fractures. Puerarin, a phytoestrogen extracted from Pueraria lobata (Willd.) Ohwi, has been identified as a promising intervention for preventing bone loss and promoting bone regeneration. However, the underlying mechanisms for its anabolic action are still not clear. In the present study, we aimed to investigate the effect of puerarin on the osteogenic differentiation of bone marrow stromal cells (BMSCs) and the possible molecular mechanism mediating its action.METHODS: Bone marrow stromal cells (BMSCs) and intragastric administration on ovariectomized(OVX) rats were used to study the anti-osteoporotic function of puerarin. The involvement of mitogen-activated protein kinase (MAPK) signaling pathways was determined.RESULTS: Our results demonstrated that at optimal concentration, puerarin could promote osteogenic differentiation of BMSCs in vitro. This induction was mediated by MAPK signaling pathway. Further detailed study revealed that ERK1/2-Runx2 signaling pathway had more prominent effect than p38 signaling pathway in puerarin-induced differentiation of BMSCs toward the osteogenic phenotype. We also found that puerarin protected against reduction in bone mineral density and improved femur trabecular bone structure in ovariectomized rats.CONCLUSION: Our findings revealed the functional mechanism of puerarin in promoting osteogenic differentiation which involved ERK1/2 and p38-MAPK pathway and provided experimental evidence for the potential application of puerarin for estrogen replacement therapy of osteoporosis.

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02:46

Puerarin can reduce the oxidative stress damage of the retina. GreenMedInfo

PMID:  Exp Ther Med. 2017 Dec ;14(6):5480-5484. Epub 2017 Sep 27. PMID: 29285079 Abstract Title:  Effects of puerarin on the retina and STAT3 expression in diabetic rats. Abstract:  The effects of puerarin on electroretinogram, oxidative stress and STAT3 expression were determined, in diabetic rat retina and serum. Forty Sprague-Dawley rats were randomly divided into the normal control (NC), the diabetic model (DM), the low dose (250 mg/kg) puerarin (LP) or the high dose (500 mg/kg) puerarin group (HP). A diabetic rat model was induced by streptozotocin and animals were continuously treated for 4 weeks; fasting blood glucose was measured at 2 and 4 weeks after modeling. An electroretinogram and serum and tissue levels of glucose, insulin, superoxide dismutase (SOD), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) were measured; real-time PCR and ELISA were used to determine STAT3 mRNA and protein expression, respectively, from the retina. The blood glucose and insulin levels in the puerarin groups were significantly lower and higher, respectively than that in the DM group. The amplitude of b-wave of electroretinogram in the DM and the LP groups was significantly lower than that in the NC group; in the LP and HP groups it was significantly higher than the DM group. The serum and retinal tissue activity of SOD and MDA was significantly lower and higher, respectively, in the DM group compared to the NC group; both the LP and HP groups had significantly higher SOD and lower MDA than the DM group. The levels of STAT3 mRNA and protein levels in the DM, LP and HP groups were significantly higher than the NC group; and levels of STAT3 mRNA and protein expression were significantly lower in the LP and HP groups than the DM group. In summary, puerarin can reduce the oxidative stress damage of the retina, and its mechanism is related to the inhibition of STAT3 expression.

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02:43

Glyphosate Should Be Banned By EPA And The LawIts A Hormone Disruptor Natural Blaze

By Catherine J. Frompovich

More and more information is surfacing, almost daily, about adverse health effects regarding herbicides, pesticides and agricultural chemicals, specifically glyphosate, the prime active in Monsantos Roundup.

What consumers need to know is that most crops now are staged several days prior to harvest with glyphosate to have uniformly desiccated crop yields! The most commonly staged field crops are: Wheat, Feed Barley, Tame Oats, Canola, Flax, Peas, Lentils, Soybeans and Dry Beans.

Glyphosate residues also have been found in off the store shelf brands in foods purchased from supermarkets.

Shouldnt feeding poisonous herbicides to humanschildren, in particularbe considered a crime?

Where are the #MeToo political action groups at federal and...

02:42

Which Bottled Water Brands Contain the Most Plastic in Their Water? Natural Blaze

Which Bottled Water Brands Contain the Most Plastic in Their Water?

By 

Many Americans drink bottled water, the market for which has grown to $147 billion in recent years. Despite this rapid growth, there are emerging health concerns with drinking bottled water, notably from the chemicals used in the production of plastic which, as our friends at Mercola.com point out, have hormone-mimicking activity that threaten human health. A recent report tested top bottled water brands to see which were the most contaminated with plasticand the results may shock you. Action Alert!

Researchers at the State University of New York, commissioned by the non-profit Orb Media, tested 259 bottles of eleven top brands of bottled water for the presence of microscopic plastic. Only seventeen of the 259 bottles were free of microplastic particles, and none of the brands were consistently free of plastic in the water.

02:38

Puerarin protects endothelial progenitor cells from damage of angiotensin II. GreenMedInfo

PMID:  Mol Med Rep. 2018 Mar ;17(3):3877-3883. Epub 2017 Dec 19. PMID: 29359784 Abstract Title:  Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2Nrf2 signaling pathway. Abstract:  Endothelial progenitor cell (EPC) dysfunction is associated with the formation of carotid atherosclerosis. It has been demonstrated that angiotensin II (Ang II) may impair the function of EPCs and puerarin, a natural product, possesses cardiovascular protective effects against oxidative stress and inflammation. Therefore, the present study aimed to investigate the beneficial effects of puerarin in Ang IIinduced EPC injury, and to elucidate the underlying mechanisms. Treatment with Ang II suppressed EPC proliferation and migration, increased the expression of the senescence marker galactosidase, and the adhesion molecules intracellular adhesion molecule1 and vascular cell adhesion molecule1. However, the above effects were markedly alleviated by treatment with puerarin in a dosedependent manner (1, 10 and 100 M). In addition, Ang II significantly increased reactive oxygen species production and the levels of the inflammatory cytokine tumor necrosis factor and interleukin6. Notably, these effects were reversedby puerarin. However, it was identified that the impaired EPC functions were due to inhibition of the phosphorylation of extracellular signalregulated kinase 1 and 2 (ERK1/2) and the degradation of nuclear factor erythroid 2 like 2 (Nrf2), and treatment with puerarin activated the ERK1/2Nrf2 signaling pathway. The results of the present study indicated that puerarin protected Ang IIinduced EPC dysfunction via activation of the ERK1/2Nrf2 signaling pathway.

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01:02

Regenerative ability of stem cells is boosted by fasting Health Nut News

As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more difficult to recover from gastrointestinal infections or other conditions that affect the intestine. This age-related loss of stem cell function can be reversed []

The post Regenerative ability of stem cells is boosted by fasting appeared first on Health Nut News.

00:30

Surprisingly, this plant slashed tumor growth better than chemo Health Nut News

By Dr. Mercola Medical cannabis has a long history as a natural analgesic, and is now legal in 30 U.S. states, the majority of which allow limited use of medical marijuana under certain medical circumstances. The medicinal qualities of marijuana are primarily due to high amounts (about 10 to 20 percent) of cannabidiol (CBD), medicinal terpenes and []

The post Surprisingly, this plant slashed tumor growth better than chemo appeared first on Health Nut News.

00:16

Autoimmunity and metal implants, devices, and vaccine adjuvants Health Nut News

By Amanda Just, MS, and Jack Kall, DMD, MIAOMT, World Mercury Project Partner Autoimmune diseases are on the rise, with more and more people being stricken with these illnesses each year. The fact that the average persons overall exposure to chemicals, including metals, has drastically increased over the past century cannot be overlooked when discussing the synonymous []

The post Autoimmunity and metal implants, devices, and vaccine adjuvants appeared first on Health Nut News.

Thursday, 17 May

23:42

Royal Family Opens Massive Vaccine Research Facility Vaxxter

The Royal wedding is this weekend and many Americans will be glued to their Televisions idolizing what they see as a fairy tale narrative play out on global TV. Of course, all the real problems...

The post Royal Family Opens Massive Vaccine Research Facility appeared first on Vaxxter.

17:06

North Texas Municipal Water District fights critics with a dirty Web trick Fluoride Action Network

Lets start with a dirty trick.

Is the North Texas Municipal Water District playing honest with its almost 2 million customers when it disputes Erin Brockovich and says its water is as pure as a mountain stream?

The Watchdog doesnt know the answer to that scientific question yet, but I can tell you something the district did that puts a big credibility question mark on its back.

I first heard about this dirty trick the other night at the Plaza Theatre in Garland. Two clean water groups have merged to relaunch the age-old campaign of how to remove fluoride and other chemicals from our water.

Jamie Stephens of Frisco was speaking on stage about her new group, Safer Water North Texas, which picked up 13,000 Facebook followers in only a few weeks. Thats remarkable, and it shows how concerned members of the public are about this topic.

Jamie Stephens, co-founder of the Safer Water North Texas Facebook group, accuses the North Texas Municipal Water District of hijacking their website by changing one letter in the URL. People trying to get to the Safer Water website might get confused.(Ben Torres/Special Contributor)
Jamie Stephen...

16:53

Oldhams oral health improves significantly, the biggest change in Greater Manchester Fluoride Action Network

[Note from FAN: Oldham is not fluoridated]

Oldham Council is celebrating the results of a national oral health survey, showing it is the local authority that has made the biggest improvement in Greater Manchester.

Oldham Council is celebrating the results of a national oral health survey, showing it is the local authority that has made the biggest improvement in Greater Manchester.

The survey measured the levels of dental decay in five year olds and showed that Oldhams oral health has improved by 16.1 per cent since the last survey in 2014/15. This puts Oldham as the fourth highest performing authority in Greater Manchester previously ninth.

Councillor Eddie Moores, Cabinet Member for Health and Wellbeing said Were very pleased with the results as they show our oral health strategy to focus on improving oral health in the under fives is succeeding.  We are continuing to work hard  in partnership with midwives, health visitors, children centres, school nurses and oral health workers to raise the awareness of the importance of looking after the teeth of our young people.

We recognise that there is still much to do, particularly to narrow the gap with the national average. To do this we have a number of initiatives in place, not least being part of Greater Manchesters Start Well programme which aims to improve oral health by building on our existing provision.

Through Start Well, supervised toothbrushing will be delivered in early years settings, school nurseries and reception classes in Oldham.

Families will be given oral health advice and fluoride toothpaste and toothbrushes from their health visitors and from those Dental Practices who are part of the Baby Teeth DO Matter scheme.  Children from three years old onwards will also have fluoride varnish applied at least twice a year.

Tooth decay and gum disease can be prevented and it is important to begin brushing your childs teeth as early as possible. This is why health visitors across the borough are giving toothbrushes and paste to new mums as part of the information packs they receive.

The results of the dental health survey are timely, coinciding with National Smile Month which runs between Monday 14 May and Thursday 14 June. This Smile Month were taking the opportunity to encourage parents to get into the toothbrushing habit with events across Oldhams Childrens Centres. For a full list of events please visit www.oldham.gov.uk/smilemonth

Oral health advice and services can also be accessed at our Right Start Childrens Centres. To find yours visit www.oldham.gov.uk/childrens_centres

*Original article online at...

14:26

Metro eyes St. Paul Park refinery following Superior explosion Fluoride Action Network

ST. PAUL PARK The St. Paul Park refinery, recently sold to Marathon Petroleum, is under fire from legislators and the community for housing hydrogen fluoride after the explosion at Husky Energy refinery in Superior, Wis.

The Star Tribune reported last week that records found at the Chicago Environmental Protection Agency office record a worst-case scenario where over 1.5 million people in a 19-mile radius of the refinery could be affected by emissions from the refinery in an emergency situation.

High levels of hydrogen fluoride inhalation or contact with skin can cause death from fluid buildup in lungs or irregular heartbeat. Contact with the eyes can also cause blindness.

Within about a mile radius of the refinery are the Newport Elementary School, Oltman Middle School and the soon-to-open new Oltman Middle School on 65th Street.

Two state Legislators Rep. Frank Hornstein, DFL-Minneapolis and Sen. Scott Dibble, DFL-Minneapolis and U.S. Rep. Betty McCollum have sent letters to agencies including the Minnesota Department of Public Safety, Pollution Control Agency and Marathon Petroleum to try and end the use of hydrogen fluoride in this and other refineries.

During a Bulletin interview in December, Andeavor spokeswoman Destin Singleton said its common practice for refineries to have a buffer zone a strip of land between the refinery and the rest of the community for safety, protection and to control access to the grounds. The size of a buffer zone depends on the refinery and on whats for sale around the site.

The refinery owns a few hundred surrounding acres for buffer land, including 160 acres on the other side of Highway 61, obtained through voluntary sales by individual land or home owners.

Many St. Paul Park homes are closer to the refinery than much of that buffer land, including Broadway Avenue, which directly abuts the refinery.

Check back for more as RiverTown Multimedia investigates the use of hydrogen fluoride at the St. Paul Park refinery.

*Original article online at http://www.swcbulletin.com/news/government-and-politics/4446827-metro-eyes-st-paul-park-refinery-following-superior-explosion

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