IndyWatch Health Watch Feed Archiver

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

IndyWatch Health Watch Feed was generated at Community Resources IndyWatch.

Tuesday, 18 September

01:28

Efforts To Protect Us From Unproven 5G Cell Towers Radiation Health Effects Natural Blaze

By Catherine J. Frompovich

Americans for Responsible Technology and Grassroots teamed up the week of September 9, 2018 to visit members of the U.S. Congress House and Senate Commerce Committees, which have jurisdiction over the Federal Communications Commission, in order to inform legislative directors and aides about the science on wireless radiation, which has been memory-holed by all who fast track 5G wireless with its special cell towers that must be placed within very close proximity to consumers residences, or even on their properties, in order to implement that technology.

The team discussed long-outdated exposure guidelines of the FCC, and the fact that no federal agency is currently authorized to consider the health impacts of deployment. Those guidelines were set in 1996!

According to the email I received from the group,

The wireless companies and their friends at the FCC have decided that Congress moves too slowly, and theyre afraid that the STREAMLINE ACT wont be passed this session. Meanwhile, more and more studies and articles a...

01:18

5 Likely Hurricane Aftermath Scenarios To Prepare For Natural Blaze

5 Likely Hurricane Aftermath Scenarios To Prepare For

By Lisa Egan

It is currently hurricane season for the Atlantic and Pacific regions of the United States.

As I write this article, Hurricane Florence is a Category 3 storm with the potential to reach Category 4 status. As of now, the storm has an uncertain path, but East Coast folks please watch this one closely, as some models suggest it could head right for you.

Helene and Issac could form in the Atlantic later this week. In the Pacific, Hurricanes Olivia and Norman are being watched closely.

Hurricanes are unpredictable, as anyone who has experienced one knows. This makes them challenging to prepare for, but fortunately, there are things you can do to increase your odds of survival, should one head for your region.

It is important to understand that a hurricane need not be a Category 5 to be incredibly dangerous and cause serious damage. When Hurricane Isabel hit my Virginia neighborhood in 2003, the storm was barely a Category 1. It was the first (and to date, the only thankfully) hurricane Ive experienced personally, and back then I really had no idea how difficult the aftermath would be.

...

00:21

Weather Channel reporter filmed being overly-dramatic as men in shorts casually stroll by Health Nut News

While we totally understand that the news cycle is 24 hours now and competition between networks exists, even this was a stretch. I mean, over-exaggerate and you just might get caught: Mike Seidel is a Weather Channel reporter who was out and about in North Carolina covering Hurricane Florence. Whilst shooting in Wilmington he was []

The post Weather Channel reporter filmed being overly-dramatic as men in shorts casually stroll by appeared first on Health Nut News.

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Monday, 17 September

23:48

Bobs Red Mill faces class action lawsuit over glyphosate weedkiller contamination Health Nut News

Bobs Red Mill is facing a federal class action, filed in San Francisco Friday, after the worlds most used weedkiller, glyphosate, was discovered in both its organic and non-organic oats. RELATED STORY: ABC: General Mills hit with lawsuit over glyphosate-containing Cheerios Citing a recent report by the Environmental Working Group finding traces of the known carcinogen glyphosate in Cheerios, Quaker []

The post Bobs Red Mill faces class action lawsuit over glyphosate weedkiller contamination appeared first on Health Nut News.

23:45

To the Doctor that Injured My Child The Thinking Moms' Revolution

September 17, 2018 To the Doctor that Injured My Child: Im sure you dont remember me, but I will never be able to forget you. I vividly remember your kind eyes and gentle touch, your sense of humor and calm Continue reading

The post To the Doctor that Injured My Child appeared first on The Thinking Moms' Revolution.

23:36

Top herb can wreak havoc on nearly all tumor cells Health Nut News

Turmeric, a yellow curry spice used in Indian cuisine, has a long history of medicinal use in traditional Chinese medicine (TCM) and Ayurvedic medicine. Curcumin is one of the most well-studied bioactive ingredients in turmeric, having over 150 potentially therapeutic activities, including anti-inflammatory, antimicrobial and powerful anticancer actions. RELATED STORY: Top Ayurvedic home remedies and practices to improve []

The post Top herb can wreak havoc on nearly all tumor cells appeared first on Health Nut News.

23:31

Deadly Virus Spreads Worldwide, Claims First Death in Canada Lyra Nara Natural Remedies

Hundreds of cases of the West Nile Virus have been reported so far this year and 22 people have already

23:04

Aspirin Has No Benefit, May Increase Cancer Mortality -- NEJM Study Reveals GreenMedInfo

Bayers headaches dont stop with Monsanto-related buyers remorse. Their most iconic pharmaceutical -- aspirin -- which they once marketed as a 'wonder drug' is now being revealed to have no benefits to older adults, and may even cause significant harm. 

read more

22:15

The Lost Cures GreenMedInfo

Where have all the cures gone? We used to think that insulin was the cure for diabetes, but now we know better. We used to cure infections with antibiotics, but now were not so sure its a good idea to medicate every infection. We used to cure warts with the strangest things, but now warts appear to be incurable. Are we losing the fight against disease?

read more

21:40

Researcher who once tried to sue critics has another dozen papers retracted Retraction Watch

A cancer researcher who went to court unsuccessfully claiming that commenters on PubPeer had cost him a new job has just lost another 12 papers. The twelve now-retracted papers by Fazlul Sarkar and colleagues as well as another by Sarkar that is now subject to an editors note all appeared in Continue reading Researcher who once tried to sue critics has another dozen papers retracted

20:29

A Letter from Peter C Gtzsche Following his Expulsion From The Cochrane Collaboration & The Chaos within the Group AGE OF AUTISM

Note: Striking letter below from Dr. Peter Gotzsche, Director of the Nordic Cochrane Centre. Please see the original pdf letter here. Background: What is Cochrane? The Cochrane Collaboration is a global independent network of researchers, health professionals, patients, carers, and...

20:02

APA Statement on Proposal to Lengthen Detention of Child Migrants Mad In America

From the American Psychological Association: Following is the statement of American Psychological Association President Jessica Henderson Daniel, PhD, in response to the Trump administrations proposal to detain migrant children beyond the 20 days allowed by current law:

We are dismayed that the administration continues to place the mental and physical health of migrant children and their families in jeopardy. Holding children even with their parents in these federal facilities for longer than the 20 days allowed by current law is unacceptable. Research has shown that immigrant detainees are particularly vulnerable to psychological stress. Furthermore, the longer the detention period, the greater the risk of depression and other mental health symptoms for immigrants who were previously exposed to interpersonal trauma.'

Article

20:01

Teen Mental Health Crisis Magnified by Demise of Creative Subjects Mad In America

From The Conversation: To thrive emotionally, young people need their own time and space, that is not explicitly directed at particular outcomes. This should be an arena in which diverse groups of young people can form their identities and agendas perhaps with the non-coercive oversight of sympathetic adults. The arts provide some of the key forums for this I gratefully remember the music teacher that helped me and my friends set up our band in the lunch break.

To try and tackle the challenge young people are facing, the government could start by mandating time and space in schools for exploratory, informal, and pupil directed activity. This could be done by reinstating leisurely lunch breaks and allowing for extracurricular activities within them. Arts and sports lessons also must be restored where they have been reduced within the curriculum.

The education sector should pay attention to solutions to the mental health crisis which arise from young people themselves Im thinking of the group of GCSE students whose protest on Londons tube trains proclaimed the human cost of pupil exclusions in a system focused on exam results rather than compassion and support.

As mental health campaigner Natasha Devon points out, self-harm is frequently a way of being heard. Perhaps then, if we help young people find other, more creative outlets, we might find it easier to hear what theyre trying to tell us.

Article

15:00

How Curcumin Targets Cancer Articles

By Dr. Mercola

Turmeric, a yellow curry spice used in Indian cuisine, has a long history of medicinal use in traditional Chinese medicine (TCM) and Ayurvedic medicine. Curcumin is one of the most well-studied bioactive ingredients in turmeric,1 having over 150 potentially therapeutic activities, including anti-inflammatory, antimicrobial and powerful anticancer actions.

Cancer has an incredible global impact and places a vast financial and emotional burden on the families it touches. Nearly 40 percent of American men and women will be diagnosed with cancer in their lifetime and over $125 billion is spent annually on medical treatment and patient care.2

The American Cancer Society estimated there would be over 1.6 million new cases diagnosed in 2017, equating to 4,630 new cases and 1,650 deaths every day.3 The most common types of cancer include breast, colon, lung and prostate.4

Despite advances in cancer treatment protocols, scientists realize prevention plays an essential role in reducing the number of people who die from the disease. After 30 years of testing more than 1,000 different possible anticancer substances, the National Cancer Institute announced that curcumin has joined an elite group that will now be used in clinical trials for chemoprevention.5

Curcumin May Play a Multitargeted Role Against Cancer Cells

In this interview, Dr. William LaValley discusses the interaction curcumin has on cancer and the multiple ways this molecule affects cancer growth. If you have ever been diagnosed with cancer, it may feel as if it grew overnight when, in fact, cancer cells take years to develop.

The progression of a cell from normal growth to cancer happens through several stages. Deregulation of physiological and mechanical processes that initiate and promote the growth of cancer cells makes use of hundreds of genes and signaling routes, making it apparent a multitargeted approach is needed for prevention and treatment.

Research has demonstrated that curcumin has a broad range of actions as it is able to effect multiple cellular targets....

Can Potatoes Be Considered Healthy? Articles

By Dr. Mercola

According to the U.S. Department of Agriculture (USDA),1 potatoes hold the top spot for highest daily per capita consumption of vegetables in the American diet, edging out tomatoes. This means the average person consumes 48 pounds of potatoes annually, of which about 40 percent are frozen.

While commonly known as a vegetable, due to their nutritional composition, potatoes are better classified as a starch. On the positive side, potatoes are rich sources of fiber, vitamins B and C and minerals like iron and potassium. When cooked then chilled, regular potatoes become a resistant starch, making them easier to digest.

Sadly, the majority of potatoes sold and consumed in the U.S. and elsewhere are in the form of french fries and potato chips. You should avoid these potato types due to the lack of nutrition they provide and also as a way to reduce your exposure to a neurotoxic chemical called acrylamide, which is found in browned or charred foods.

Also, because potatoes are grown in soil, and soil conditions vary widely around the globe, you may be increasing your exposure to toxic pesticides and heavy metals every time you eat a tuber. For that reason, its best to purchase organic potatoes and moderate your intake, keeping in mind that even organic brands can be tainted with heavy metals.

The Origin of Potatoes

As a member of the Solanaceae or nightshade family, regular potatoes are related to eggplants, peppers and tomatoes. As such, they are a potentially inflammatory food. Potatoes originated in South America, specifically in the Andes Mountains region, and 4,000 edible varieties are said to exist worldwide.2

In the 16th century, Spanish explorers introduced potatoes to Europe. Due to their vitamin C content, potatoes were used during sea voyages to help combat scurvy. In the 18th century, Irish immigrants brought the potato to the U.S.

Today, potatoes are cultivated worldwide, taking their place behind rice and wheat as the worlds third largest crop in terms of human consumption.3 Notably, due to their moderate-to-cool climates, the states of Idaho and Washington produce about half the potatoes consumed in the U.S.4

Each type of regular potato, as well as sweet potato, varies in shape, size, color, flavor and nutritional content.

What Makes Potatoes Healthy?

As mentioned in the featured video, a medium plain baked potato eate...

Weekly Health Quiz: Cumin, Autism and Insulin Articles

1 Which of the following supports healthy thyroid function, boosts metabolism and helps normalize insulin and leptin function?

  • Trans fat
  • Vegetable oils
  • Margarine
  • Coconut oil

    Coconut oil supports thyroid function, normalizes insulin and leptin function, boosts metabolism and provides excellent and readily available fuel for your body in lieu of carbohydrates. Learn more.

2 How many carcasses per minute must USDA food inspectors inspect for signs of disease and fecal material in chicken slaughter lines?

  • 140

    Food inspectors visually inspect 140 carcasses per minute between two and three chickens per second for the presence of fecal material; they test for drugs and bacteria during spot checks only. Learn more.

  • 100
  • 50
  • 10

3 Chagas disease is contracted from and spread by which of the following insects?

  • Ticks
  • Triatomines, aka "kissing bugs"

    Chagas infection is contracted through a bite from a triatomine, a nocturnal insect that crawls around on your face while you're sleeping. It will typically bite around the lips or eyes hence the nickname "kissing bug." Learn more.

  • Mosquitoes
  • Spiders

4 Which of the following placebo treatments or criteria has been shown to be the most effective?

  • Large placebo capsules
  • Small placebo tablets
  • Sham surgery

    The placebo effect taps...

Can Okra Help Control Your Hunger and Diabetes? Articles

By Dr. Mercola

What vegetable looks like a cross between a jalapeno, a mini cucumber and a star fruit, has enjoyed a long Southern tradition and was recently found to provide some really incredible benefits for your health? If your answer was okra, you get a thumbs-up, and if you or someone you care about struggles with their blood sugar, not to mention bouts of hunger that only exacerbates their blood sugar woes, listen up.

But first, a little okra history: Also called "ladyfingers," and closely related to both cotton and hibiscus, okra comes in more than one variety, so it can be tinged with red and have either a smooth or a rough and even prickly texture.

A favorite in the American South and areas of Africa and the Mediterranean, where it's usually cooked to reveal a slimy texture, there are (fortunately) serving alternatives; five possibilities, with a few twists, are inspired by Smithsonian Magazine:1

  • Fried okra is the traditional Southern way of serving okra, involving corn meal and so-called "vegetable oils," but it's not the healthiest. If you choose to eat fried okra, at least be sure you use a healthy cooking oil (mentioned below), perhaps with a sprinkling of Parmesan cheese added, and cook it at a lower temperature.
  • Gumbo with okra2 for taste and as a thickening agent with the obligatory "holy trinity" of bell pepper, onion and celery is a Southern staple. In fact, the African name "gombo" is where the recipe was derived. It's often mixed with meat, tomatoes and bay leaves.
  • Pickled okra,3 especially the sweet and spicy variety, is another way to serve this little pod, often with dried chilies, black peppercorns, mustard seeds, hot peppers, vinegar, fresh dill, salt and rice wine vinegar.
  • Grilled or oven-roasted okra4 can be as simple as dousing clean, quartered okra pods with olive oil and sprinkling them with salt and pepper on a baking sheet, then cooking for 15 minutes. The best part: It's not slimy and actually becomes partially caramelized.
  • Stewed okra is a great way to add the nutrients but with stronger-flavored flavors, such as beef broth, lamb, balsamic vinegar, cloves, tomato paste, garlic, mint leaves and spices, like in the case of banya,5 an Egyptian meat and okra stew.

It should be noted that far healthier oils than the standard fare include...

10:48

Medicinal Health Benefits of Turmeric and Curcumin Based on Science Healthy and Natural World

Turmeric is a spice with antioxidant, antimicrobial, and anti-aging properties. It has an earthy aroma and taste. Turmeric contains curcumin which is what gives turmeric its many medicinal health benefits. Research into curcumin has shown that it can help reduce inflammation, improve your heart health, detoxify your body, promote digestive health, and has been linked with weight loss.

You can also use turmeric as a topical treatment to help improve the appearance of your skin. The anti-inflammatory properties of turmeric mean that it can also help treat a number of skin conditions.

Turmeric is related to ginger which also has many health benefits. You can add turmeric to spice up dishes or take curcumin supplements to address many health conditions. Many studies show that you can take between 1,000 mg and 2,500 mg turmeric extract a day for its anti-inflammatory and medicinal benefits.

In this article, you will find out what science says about the many health benefits of turmeric and curcumin. You will also learn how to make your own turmeric anti-inflammatory tea at home.

Turmeric Contains Powerful Medicinal Properties

Turmeric has been described as the Golden Spice both for its color and amazing medicinal properties. Turmeric belongs to the Curcuma longa genus and is a root herb.

Research has revealed that there are over 100 bioactive components in turmeric. The most potent compound in turmeric is a group called curcuminoids. From the curcuminoids, curcumin is the powerful medicinal compound that is used in many supplements. (1)

Turmeric also contains potassium, iron, thiamine, some B-group vitamins, and omega-3 fatty acids. (1)

Turmeric has a long history of use in traditional Chinese medicine and Ayurveda. Recent scientific research has backed up many of the traditional uses of curcumin. A report from 2017 found that the antioxidant and anti-inflammatory properties of curcumin have multiple health benefits. (2)

The proportion of curcumin in turmeric is fairly low. Studies have shown that only about 3% of turmeric is curcumin. Therefore, to really benefit from turmeric, you should look for curcumin supplements with a high curcuminoid content. (3)

One important way to make sure and get the benefits of turmeric or curcumin is to take it with black pepper. Research into curcumin shows that it is poorly absorbed by the body. However, adding piperine or black pepper boosts its absorption by up to 2,000%. (4)

That is...

09:28

Rip-offs In Healthcare, Especially Prescription Drugs Natural Blaze

By Catherine J. Frompovich

The healthcare or shall I call it sickness care industries in the United States and, perhaps globally, apparently operate under several misleading practices of being there to help consumers get well.

Although that sounds altruistic, nothing probably is further from factual and monetary truths, according to many concerned individuals who recognize what amounts to rip-offs and are calling it out for what it is.

In view of the exorbitantly annual increases in healthcare insurance premiums and prescription drug plans, consumers and regulatory agencies must step back to reassess what the hell is going on with price increases that prevent those folks who take prescription drugs from either cutting back on them or not being able to afford them in the first place.

One of the prime areas of apparent deceitful healthcare practices to investigate is found in prescription pharmaceuticals where mammoth monetizing goes on at various levels along the distribution...

09:25

A Serious Warning About the Toxicity of Aluminum-Adjuvanted Vaccines Especially for Infants and the Elderly Natural Blaze

By Gary G. Kohls, MD, Natural Blaze

The following article comes, slightly edited and re-formatted, from a 2015 Frontiers in Neurology Review Article. It was authored by Romain Kroum Gherardi, Housam Eidi, Guillemette Crpeaux, Franois Jerome Authier and Josette Cadusseau (of the Facult de Mdecine and Facult des Sciences et Technologie, INSERM U955 Team 10, Universit Paris Est-Crteil, Crteil, France)

(The original English journal article is available online at https://www.frontiersin.org/articles/10.3389/fneur.2015.00004/full)

Following are two important passages from the article plus a note from the Duty to Warn editor prefacing the article:

Aluminum has long been identified as a neurotoxic metal, affecting memory, cognition and psychomotor control, altering neurotransmission and synaptic activity, damaging the bloodbrain barrier (BBB), exerting pro-oxidant effects, activating microglia and neuroinflammation, depressing the cerebral glucose metabolism and mitochondrial functions, interfering with transcriptional activity, and promoting beta-amyloid and neurofilament aggregation.

Aluminum adjuvants are currently used in vaccines against tetanus, hepatitis A, hepatitis B, human papillomavirus, haemophilus influenzae B, pneumococcal and meningococcal infections, and anthrax.

(Ed. note: Such alumi...

09:20

As Families Become Outlaws to Treat Epilepsy with Cannabis, Colorado Kids Can Now Bring It To School Natural Blaze

By John Vibes

Eagle, CO Fourth grader Quintin Lovato suffers from epilepsy and Tourettes syndrome, and for most of his life these conditions have made living a normal life nearly impossible for him. Quintin had trouble with basic functions and could barely walk until his family discovered the healing power of cannabis oil. Luckily, Quintin lives in Colorado where cannabis is legal and considered medicine, and he has been able to treat his debilitating conditions with the herb legally.

Quintin has seen radical improvements in his condition thanks to cannabis, and it has helped him to start living a normal life. Quintin has even been able to take his medicine to school this year so that he can be in his best shape for class.

Its the first day of school where Quintin gets to take his cannabis to school, his mother Hannah Lovato told KDVR.

I honestly think if he wasnt taking cannabis for his seizures and Tourettes he probably I dont know if hed be going to public school to be honest with you, Hannah added.

Quintins reading teacher Terry Plain is now a believer...

08:29

Blue light irradiation inhibits the production of hepatocyte growth factor by human retinal pigment epithelium cells. GreenMedInfo

PMID:  Photochem Photobiol. 2006 Sep-Oct;82(5):1247-50. PMID: 16740060 Abstract Title:  Blue light irradiation inhibits the production of HGF by human retinal pigment epithelium cells in vitro. Abstract:  Blue visible light damage to retinal pigment epithelial cells occurs through a photooxidative mechanism and the resultant damage is hypothesized to induce or exacerbate age-related macular degeneration. The purpose of the present study was to identify changes in the cell growth and the expression of hepatocyte growth factor (HGF) in cultured human retinal pigment epithelium (RPE) cells as a result of both blue and red light irradiation. HGF is a growth factor and neurotrophic factor that stimulates growth of various ocular cells and promotes the survival of RPE and retinal neurons. Early passages of human RPE cells were exposed to blue light (460 nm) and red light (640 nm). Nonirradiated cells were used as controls. After 24 and 48 h, conditioned medium was collected and the amount of HGF was measured by ELISA. Cells were detached from the well and counted. Cell viability was evaluated by trypan-blue exclusion study. Blue light at dosage of 63 J/cm(2) significantly inhibited the growth of RPE cells without affecting of cell viability. Amounts of HGF in the culture medium were significantly inhibited by blue-light irradiation at the dosage from 32 to 63 J/cm(2). Red light at a dose of 174 J/cm(2) causes a nonsignificant inhibition of growth of RPE cells and a slight decrease of secretion of HGF. As HGF promotes survival of RPE cells and retinal neurons, the inhibition of production of HGF by visible light, especially by blue light, may enhance the phototoxic effects of visible light on the RPE and retinal neurons.

read more

08:22

Antibiotic Resistance Doom and Bloom (TM)

Antibiotic Resistance

ANTIBIOTIC RESISTANCE   (The following is an excerpt from our upcoming book on antibiotic and bacterial disease) When modern medical care isnt available, many deaths would be prevented by the availability of antibiotics in your disaster medicine cabinet. Indeed, you should consider having a supply of these drugs in your storage if you believe a []

08:17

Blue-light filtering spectacle lenses can partially filter high-energy short-wavelength light without substantially degrading visual performance. GreenMedInfo

PMID:  PLoS One. 2017 ;12(1):e0169114. Epub 2017 Jan 3. PMID: 28045969 Abstract Title:  Blue-Light Filtering Spectacle Lenses: Optical and Clinical Performances. Abstract:  PURPOSES: To evaluate the optical performance of blue-light filtering spectacle lenses and investigate whether a reduction in blue light transmission affects visual performance and sleep quality.METHODS: Experiment 1: The relative changes in phototoxicity, scotopic sensitivity, and melatonin suppression of five blue-light filtering plano spectacle lenses were calculated based on their spectral transmittances measured by a spectrophotometer. Experiment 2: A pseudo-randomized controlled study was conducted to evaluate the clinical performance of two blue-light filtering spectacle lenses (BF: blue-filtering anti-reflection coating; BT: brown-tinted) with a regular clear lens (AR) serving as a control. A total of eighty computer users were recruited from two age cohorts (young adults: 18-30 yrs, middle-aged adults: 40-55 yrs). Contrast sensitivity under standard and glare conditions, and colour discrimination were measured using standard clinical tests. After one month of lens wear, subjective ratings of lens performance were collected by questionnaire.RESULTS: All tested blue-light filtering spectacle lenses theoretically reduced the calculated phototoxicity by 10.6% to 23.6%. Although use of the blue-light filters also decreased scotopic sensitivity by 2.4% to 9.6%, and melatonin suppression by 5.8% to 15.0%, over 70% of the participants could not detect these optical changes. Our clinical tests revealed no significant decrease in contrast sensitivity either with (95% confidence intervals [CI]: AR-BT [-0.05, 0.05]; AR-BF [-0.05, 0.06]; BT-BF [-0.06, 0.06]) or without glare (95% CI: AR-BT [-0.01, 0.03]; AR-BF [-0.01, 0.03]; BT-BF [-0.02, 0.02]) and colour discrimination (95% CI: AR-BT [-9.07, 1.02]; AR-BF [-7.06, 4.46]; BT-BF [-3.12, 8.57]).CONCLUSION: Blue-light filtering spectacle lenses can partially filter high-energy short-wavelength light without substantially degrading visual performance and sleep quality. These lenses may serve as a supplementary option for protecting the retina from potential blue-light hazard.TRIAL REGISTRATION: ClinicalTrials.gov NCT02821403.

read more

07:13

Visual functional effects of constant blue light in a retinal degenerate rat model. GreenMedInfo

n/a PMID:  Photochem Photobiol. 2007 May-Jun;83(3):759-65. PMID: 17115798 Abstract Title:  Visual functional effects of constant blue light in a retinal degenerate rat model. Abstract:  Retinal degenerative conditions increase susceptibility to light damage, but rapid retinal degeneration (RD) models show less susceptibility to cyclic dim light. We investigated whether constant blue light (BL) exposure can eliminate the residual visual responses in a comparatively rapid RD rat model. Pigmented rhodopsin mutant S334ter line-3 rat pups (21 days old) were exposed for 5-6 consecutive days to constant BL. Visual behavior was evaluated with an optokinetic head tracking apparatus. Electrophysiological recordings were made from the superior colliculus (SC). S-antigen, red-green opsin and rhodopsin immunoreactive residual photoreceptors were counted. Following BL exposure, head tracking was significantly reduced at 0.25 cycles degree(-1) in 38-day-old line 3 rats. With a 0.125 cycles degree(-1) stimulus, the head tracking performance of 80-day-old BL rats were similar to that of 220-day-old no-BL-treated line-3 rats. SC recordings also revealed a significant decrease in the residual photoreceptor activity. Histological evaluation showed reduction of the rod population in the central area of the light-damaged retina. Exposure to constant BL considerably reduces the residual visual responses in a rapid degenerating RD rat model.

06:56

Dr. Ben Goldacre Weighs on on Side of Vaccine Study Transparency AGE OF AUTISM

Note: Age of Autism's John Stone first wrote about Dr. Ben Goldacre in 2010 What's Behind Ben Goldacre. Read the following article Public Health England withholding vaccines results making it impossible to establish if drugs could be harmful Public Health...

06:39

Blue light exposure can induce damages to human retinal pigment epithelium cells in vitro GreenMedInfo

PMID:  Zhonghua Yan Ke Za Zhi. 2006 Dec ;42(12):1095-102. PMID: 17415967 Abstract Title:  [Relationship between blue light-induced apoptosis and mitochondrial membrane potential and cytochrome C in cultured human retinal pigment epithelium cells]. Abstract:  OBJECTIVE: To investigate the effect of blue light on apoptosis and mitochondrial permeability transition (MPT) of cultured human retinal pigment epithelium (RPE) cells in vitro.METHODS: Human RPE cells were exposed to blue light (wave length 470 -490 nm). The present study consisted of three parts. Part one studied the effect of various intensities of blue light on the RPE cells. Cells were irradiated with (500+/-100) lx (group 1) , (2000+/-500) lx (group 2) and (3000+/-500)lx ( group 3) blue light, and followed by 24 hours observation. Part two studied the effect of various duration of blue light at identical intensity on the RPE cells. For the study on various subtypes of RPE cells, cells were irradiated by blue light at (2000+/-500) x for 6, 12, and 24 hours. For the study of mitochondrial membrane potential, cells were irradiated for 3, 6, and 12 hours. Part three studied cells irradiated with blue light at identical intensity and duration, but with various prolongation of post-exposure culture. The prolongation of post-exposure culture was 6, 12, 24, and 36 hours. Phototoxicity was quantified at various periods after exposure by staining of the nuclei of membrane-compromised cells, by TdT-dUTP terminal nick-end labeling (TUNEL) of apoptotic cells and by Annexin V labeling for phosphatidylserine exposure. Transmission electronmicroscopy was used to determine the ultrastructure changes of RPE cells. Mitochondrial membrane potential ( deltaPsim ) was measured by rhodamine 123 staining and subsequent flow cytometry. Cytochrome C activity was assayed by ELISA. Caspase-3 was detected by colorimetric assay.RESULTS: TUNEL-positive labeling cells in first group of part two study showed cell shrinkage, membrane blebbing, apoptotic body, condensation and fragmentation of chromatin. Mitochondrial swelling, extinction of inner mitochondrial membrane ridge, dilation of rough endoplasmic reticulum and increase of the lysosome were also observed in transmission electronmicroscopy. Blue light at (500 +/- 100) x intensity did not induce damage to RPE cells, but decrease of delta Psim was observed. A significant increase of apoptotic, apoptotic necrotic and necrotic percentages, as well as significant decrease of deltaPsim were observed at higher light intensity in part one study. Increase of apoptotic percentage was the main response to shorter exposure of blue light. Increase of apoptotic necrotic and necrotic percentage and pronounced decrease of deltaPsim occurred in cells irradiated by longer exposure in part two study. In part 3 study, ap...

06:20

Blue light-absorbing intraocular lenses further reduced damage compared to the conventional intraocular lenses. GreenMedInfo

PMID:  Ophthalmologe. 2010 Feb ;107(2):150-7. PMID: 19499230 Abstract Title:  [Protective effect of blue light-absorbing IOLs on the human retinal pigment epithelium]. Abstract:  METHODS: Primary human RPE cells were exposed to white light and either a SN60AT or SA60AT IOL was placed in the light beam. After 15-60 min of irradiation, viability, induction of apoptosis and cell death were determined in primary human RPE cells. Expression of vascular endothelial growth factor A (VEGF-A) and the anti-apoptotic XIAP protein and their mRNA were determined by RT-PCR, Western blot analysis and ELISA.RESULTS: Light exposure decreased cell viability depending on the duration of irradiation. Light-induced cell death and apoptosis as well as decrease of XIAP expression and cellular viability were significantly reduced by both the SN60AT and SA60AT IOL. In addition, these protective effects regarding light-induced cell damage were significantly stronger in the presence of the blue light-filtering SN60AT IOL compared to the SA60AT IOL.CONCLUSION: Both UV-filtering and blue light-absorbing IOLs reduce light-induced RPE damage. The blue light-absorbing IOL further reduced damage compared to the conventional IOL, which supports the hypothesis of possibly also preventing retinal damage in clinical use.

read more

05:30

Blue light induced A2E oxidation in rat eyes. GreenMedInfo

PMID:  Photochem Photobiol Sci. 2010 Nov ;9(11):1505-12. Epub 2010 Oct 5. PMID: 20922251 Abstract Title:  Blue light induced A2E oxidation in rat eyes--experimental animal model of dry AMD. Abstract:  Previous studies have shown that short-wavelength blue visible light induces retinal injury and may be a risk factor for age related macular degeneration. A2E is a blue light absorbing retinal chromophore that accumulates with age. Our previous in vitro studies have determined that, although A2E itself has a low phototoxic efficiency, the oxidation products of A2E that are formed in the presence of visible light can contribute to observed retinal pigment epithelial photodamage. The purpose of this study was to investigate the effects of blue light on retinal phototoxicity and its relationship to A2E, oxidized A2E and its isomers. Sprague-Dawley albino rats were dark adapted for 24 h. Control rats remained in the dark while experimental rats were exposed to blue light ( = 450 nm, 3.1 mW cm(-2)) for 6 h. Isolated retinas were homogenized in Folch extraction mixture and then in chloroform. The dried extracts were reconstituted and divided for determination of organic soluble compound. Esters of fatty acids were determined with GC-MS, A2E and other chromophores using HPLC, and A2E oxidation products with LC-MS. Exposure of rat eyes to blue light did not significantly change the fatty acid composition of the retina. The A2E concentration (normalized to fatty acid content) in blue light exposed animals was found to be lower than the A2E concentration in controlrats. The concentrations of all-trans-retinal-ethanolamine adduct and iso-A2E a precursor and an isomer of A2E respectively, were also lower after blue-light exposure than in the retinas of rats housed in the dark. On the other hand, the amount of oxidized forms of A2E was higher in the animals exposed to blue light. We conclude that in the rat eye, blue-light exposure promotes oxidation of A2E and iso-A2E to the products that are toxic to retinal tissue. Although high concentrations of A2E may be cytotoxic to the retina, the phototoxicity associated with blue light damage to the retina is inpart a result of the formation of toxic A2E oxides. This effect may partially explain the association between blue light induced retinal injury and macular degeneration.

read more

05:16

Molecular mechanism of the protective effect of lutein against retinal damage induced by blue-light in rats. GreenMedInfo

PMID:  Wei Sheng Yan Jiu. 2010 Nov ;39(6):689-92. PMID: 21351632 Abstract Title:  [Molecular mechanism of the protective effect of lutein against retinal damage induced by blue-light in rats]. Abstract:  OBJECTIVE: To explore the possible mechanisms of the protective effect of lutein against retinal damage induced by blue-light.METHODS: Ninety six female SD rats (8 week-old, 200 g) were divided into six groups: normal control (NC), blue light injury (MC), blue light + solvent (SC), blue light + 0.5 mg/ml lutein (L0.5), blue light + 1.0 mg/ml lutein (L1.0) and blue light + 2.0 mg/ml lutein (L2.0). The content of malondialdehyde (MDA) and the activities of peroxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of retina were measured as oxidative stress markers. Neuron nitricoxide synthase and the expression of c-fos protein in retina were analyzed by Western Blot.RESULTS: The content of MDA increased in the retina induced by photic injury, and the increase was protected significantly by lutein treatment (P0.05). The expression of c-fos protein was significantly higher in the retina of MC and SC group than that in lutein-treated groups (P

read more

04:44

Restoring the anti-oxidative capabilities of the retina by increasing intake of lutein and zeaxanthin reduces the likelihood of AMD and cataract. GreenMedInfo

PMID:  Med Hypotheses. 2011 May ;76(5):741-4. Epub 2011 Feb 26. PMID: 21354712 Abstract Title:  Cataract is a self-defence reaction to protect the retina from oxidative damage. Abstract:  Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. Cataract extraction is the most common surgical procedure in developed countries. Lutein (L) and zeaxanthin (Z), retinal carotenoids, are the most powerful retinal anti-oxidants and absorb the harmful blue light. The depletion of L+Z induces the development of the lens opacification-cataract. Cataract reduces the retinal oxidative stress (OS), which causes a reduction of the probability to develop AMD. Oxidative Stress at the retinal level is the common pathway in the development of AMD and cataract. AMD and cataract are not two independent processes. Cataract is a self-defense reaction of the retina to reduce OS and retinal damage. Restoring the anti-oxidative capabilities of the retina by increasing intake of L+Z reduces the likelihood of AMD and cataract. Extracting the opaque lens elevates the retinal OS and increases the rate of AMD.

read more

04:33

Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes. GreenMedInfo

PMID:  Free Radic Biol Med. 2012 Sep 15 ;53(6):1298-307. Epub 2012 Jun 23. PMID: 22732187 Abstract Title:  Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Abstract:  Oxidative damage and inflammation are related to the pathogenesis of age-related macular degeneration (AMD). Epidemiologic studies suggest that insufficient dietary lutein and zeaxanthin intake or lower serum zeaxanthin levels are associated with increased risk for AMD. The objective of this work is to test the protective effects of lutein and zeaxanthin against photooxidative damage to retinal pigment epithelial cells (RPE) and oxidation-induced changes in expression of inflammation-related genes. To mimic lipofuscin-mediated photooxidation in vivo, we used ARPE-19 cells that accumulated A2E, a lipofuscin fluorophore and photosensitizer, as a model system to investigate the effects of lutein and zeaxanthin supplementation. The data show that supplementation with lutein or zeaxanthin in the medium resulted in accumulation of lutein or zeaxanthin in the RPE cells. The concentrations of lutein and zeaxanthin in the cells were 2- to 14-fold of that detected in the medium, indicating that ARPE-19 cells actively take up lutein or zeaxanthin. As compared with untreated cells, exposure of A2E-containing RPE to blue light resulted in a 40-60% decrease in proteasome activity, a 50-80% decrease in expression of CFH and MCP-1, and an~20-fold increase in expression of IL-8. The photooxidation-induced changes in expression of MCP-1, IL-8, and CFH were similar to those caused by chemical inhibition of the proteasome, suggesting that inactivation of the proteasome is involved in the photooxidation-induced alteration in expression of these inflammation-related genes. Incubation of the A2E-containing RPE with lutein or zeaxanthin prior to blue light exposure significantly attenuated the photooxidation-induced inactivation of the proteasome and photooxidation-induced changes in expression of MCP-1, IL-8, and CFH. Together, these data indicate that lutein or zeaxanthin modulates inflammatory responses in cultured RPE in response to photooxidation. Protecting the proteasome from oxidative inactivation appears to be one of the mechanisms by which lutein and zeaxanthin modulate the inflammatory response. Similar mechanisms may explain salutary effects of lutein and zeaxanthin in reducing the risk for AMD.

read more

04:17

The End of Scientific Integrity? Cochrane Collaboration Expels Critic of Big Pharma 4 Other Board Members Resign Vaccine Impact

Dr-Peter-Gtzsche

Dr. Peter Gtzsche has become the first member to be expelled from the Cochrane Collaboration in 25 years.

Comments by Brian Shilhavy
Editor, Health Impact News

Dr. Peter Gtzsche recently sent out an email to the public explaining that he is the first person in 25 years to be expelled from the Cochrane Collaboration. He writes:

No clear reasoned justification has been given for my expulsion aside from accusing me of causing disrepute for the organization. This is the first time in 25 years that a member has been excluded from membership of Cochrane.

Four other board members have resigned from the Cochrane Collaboration as a result of this action.

Health Impact News has covered the work of Dr. Gtzsche frequently over the years, as he is an outspoken critic of Big Pharma, referring to them as organized crime.

He is author of the bookDeadly Medicines and Organized Crime: How big pharma has corrupted healthcare.

The Cochrane Collaboration is considered to be the gold standard in scientific integrity, but they have come under fire recently for what appears to be biased reviews influenced by the pharmaceutical industry.

They received a $1.15 million gift from the Bill & Melinda Gates Foundation to fund project work from 2016 to 2017. See:

Gates Foundation Buys Cochrane Integrity for $1.15 Million: The Death of Scientific Integrity

Earlier this year (2018), researchers from the Nordic Cochrane Centre published a critique in the British Medical Journal stating that the Cochranes review of the HPV vaccine does not meet the standards for Cochrane reviews or the needs of the citizens or healthcare providers that consult Cochrane reviews to make Informed decisions. See:

...

04:16

Oxidative stress is an early step leading to cellular damage by blue LED exposure. GreenMedInfo

PMID:  Free Radic Res. 2013 Oct ;47(10):774-80. Epub 2013 Aug 22. PMID: 23898883 Abstract Title:  Blue LED light exposure develops intracellular reactive oxygen species, lipid peroxidation, and subsequent cellular injuries in cultured bovine retinal pigment epithelial cells. Abstract:  The effects of blue light emitter diode (LED) light exposure on retinal pigment epithelial cells (RPE cells) were examined to detect cellular damage or change and to clarify its mechanisms. The RPE cells were cultured and exposed by blue (470 nm) LED at 4.8 mW/cm(2). The cellular viability was determined by XTT assay and cellular injury was determined by the lactate dehydrogenase activity in medium. Intracellular reactive oxygen species (ROS) generation was determined by confocal laser microscope image analysis using dihydrorhodamine 123 and lipid peroxidation was determined by 4-hydroxy-2-nonenal protein-adducts immunofluorescent staining (HNE). At 24 h after 50 J/cm(2) exposures, cellular viability was significantly decreased to 74% and cellular injury was significantly increased to 365% of control. Immediately after the light exposure, ROS generation was significantly increased to 154%, 177%, and 395% of control and HNE intensity was increased to 211%, 359%, and 746% of control by 1, 10, and 50 J/cm(2), respectively. These results suggest, at least in part, that oxidative stress is an early step leading to cellular damage by blue LED exposure and cellular oxidative damage would be caused by the blue light exposure at even lower dose (1, 10 J/cm(2)).

read more

03:58

Neuroglobin is a potential biological marker of retinal damage induced by LED light. GreenMedInfo

PMID:  Neuroscience. 2014 Jun 13 ;270:158-67. Epub 2014 Apr 18. PMID: 24747803 Abstract Title:  Neuroglobin - a potential biological marker of retinal damage induced by LED light. Abstract:  Neuroglobin (NGB), a protein highly expressed in the retina, has been shown to be up-regulated to protect neurons from hypoxic and ischemic injuries. It exhibits neuroprotective functions and plays an important role in the survival of neurons. Recent studies show that light-emitting diode (LED) white light emitted significant amounts of blue light (short-wavelength), which may be harmful to retinal cells, but the studies about biomarkers for evaluating the damage from LED white light are still insufficient. In our study, we found that NGB levels in the retina showed a twofold increase and peaked at 1h after a 1-h exposure to blue light (453 nm) which did not cause damage to the retina. However, retinal damage was observed after 2h of blue-light irradiation, which induced an approximate sevenfold increase of NGB levels as confirmed by Western blot and RT-PCR analysis. Immunofluorescence study demonstrated that NGB was predominantly up-regulated in the ganglion cell layer (GCL), plexiform layer (PL) and photoreceptor layer (PRL). We also examined Ngb mRNA and protein expression in the damaged retina induced by light of other wavelengths given equal photon fluxes. The LED red light (625 nm), green light (527 nm) and blue light (453 nm) increased the expression of NGB and caused TdT-mediated dUTP nick-end labeling-positive cells, especially in the blue-light group. In addition, a negative correlation between NGB and rhodopsin was observed. These findings suggested that there was a correlation between NGB expression and the severity of the retinal damage, indicating NGB's potential function as a biological marker of retinal damage induced by LED light.

read more

03:35

Blue LED light increased reactive oxygen species production. GreenMedInfo

PMID:  Sci Rep. 2014 Jun 9 ;4:5223. Epub 2014 Jun 9. PMID: 24909301 Abstract Title:  Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. Abstract:  Our eyes are increasingly exposed to light from the emitting diode (LED) light of video display terminals (VDT) which contain much blue light. VDTs are equipped with televisions, personal computers, and smart phones. The present study aims to clarify the mechanism underlying blue LED light-induced photoreceptor cell damage. Murine cone photoreceptor-derived cells (661 W) were exposed to blue, white, or green LED light (0.38 mW/cm(2)). In the present study, blue LED light increased reactive oxygen species (ROS) production, altered the protein expression level, induced the aggregation of short-wavelength opsins (S-opsin), resulting in severe cell damage. While, blue LED light damaged the primary retinal cells and the damage was photoreceptor specific. N-Acetylcysteine (NAC), an antioxidant, protected against the cellular damage induced by blue LED light. Overall, the LED light induced cell damage was wavelength-, but not energy-dependent and may cause more severe retinal photoreceptor cell damage than the other LED light.

read more

03:28

The effect of visual blue light on mitochondrial function associated with retinal ganglions cells. GreenMedInfo

PMID:  Exp Eye Res. 2014 Nov ;128:8-14. Epub 2014 Sep 2. PMID: 25193034 Abstract Title:  The effect of visual blue light on mitochondrial function associated with retinal ganglions cells. Abstract:  The retina is the only part of the central nervous system that is exposed to light radiation between 400 and 780 nm. Short wavelength light (SWL) ranging between 400 and 480 nm are absorbed maximally by chromophores located in mitochondria. An abundance of mitochondria are located in retinal ganglion cell (RGC) intraocular axons and photoreceptor inner segments and as a consequence SWL will impact these organelles. The purpose of this article is to summarise the experimental evidence for the possible negative effects of SWL on RGC mitochondria, in situ. The threat of damage to photoreceptor mitochondria may be less than to RGCs, since macular carotenoid, located chiefly in Henle's layer of the photoreceptor inner segment absorbs SWL. The article underlines the hypothesis that SWL contributes to RGC death when these neurones are not in an optimum homoeostatic state as is likely to occur in conditions such as glaucoma and possibly other types of pathologies and even old age. A case therefore exists for the idea that shielding RGCs to slow down visual loss in certain circumstances. This can theoretically be achieved with lenses that reduce transmission of SWL but specifically allow for maximal transmission of 479 nm light to stimulate melanopsin and maintain an optimum sleep/wake cycle.

read more

03:25

The End of Scientific Integrity? Cochrane Collaboration Expels Critic of Big Pharma 4 Other Board Members Resign Health Impact News

Dr-Peter-Gtzsche

Dr. Peter Gtzsche has become the first member to be expelled from the Cochrane Collaboration in 25 years.

Comments by Brian Shilhavy
Editor, Health Impact News

Dr. Peter Gtzsche recently sent out an email to the public explaining that he is the first person in 25 years to be expelled from the Cochrane Collaboration. He writes:

No clear reasoned justification has been given for my expulsion aside from accusing me of causing disrepute for the organization. This is the first time in 25 years that a member has been excluded from membership of Cochrane.

Four other board members have resigned from the Cochrane Collaboration as a result of this action.

Health Impact News has covered the work of Dr. Gtzsche frequently over the years, as he is an outspoken critic of Big Pharma, referring to them as organized crime.

He is author of the bookDeadly Medicines and Organized Crime: How big pharma has corrupted healthcare.

The Cochrane Collaboration is considered to be the gold standard in scientific integrity, but they have come under fire recently for what appears to be biased reviews influenced by the pharmaceutical industry.

They received a $1.15 million gift from the Bill & Melinda Gates Foundation to fund project work from 2016 to 2017. See:

Gates Foundation Buys Cochrane Integrity for $1.15 Million: The Death of Scientific Integrity

Earlier this year (2018), researchers from the Nordic Cochrane Centre published a critique in the British Medical Journal stating that the Cochranes review of the HPV vaccine does not meet the standards for Cochrane reviews or the needs of the citizens or healthcare providers that consult Cochrane reviews to make Informed decisions. See:

...

03:25

Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols. GreenMedInfo

PMID:  Food Chem Toxicol. 2014 Dec ;74:216-24. PMID: 25447759 Abstract Title:  Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols. Abstract:  Blue light induced oxidative damage and ER stress are related to the pathogenesis of age-related macular degeneration (AMD). However, the mechanism of blue light-induced damage remained obscure. The objective of this work is to assess the photooxidative damage to retinal pigment epithelial cells (RPE) and oxidation-induced changes in expression of ER stress associated apoptotic proteins, and investigate the mechanism underlying the protective effects of grape skin extracts. To mimic lipofuscin-mediated photooxidation in vivo, ARPE-19 cells that accumulated A2E, one of lipofuscin fluorophores, were used as a model system to investigate the mechanism of photooxidative damage and the protective effects of grape skin polyphenols. Exposure of A2E containing ARPE-19 cells to blue light resulted in significant apoptosis and increases in levels of GRP78, CHOP, p-JNK, Bax, cleaved caspase-9, and cleaved caspase-3, indicating that photooxidative damage to RPE cells is mediated by the ER-stress-induced intrinsic apoptotic pathway. Cells in which GRP78 had been knocked down with shRNA were more vulnerable to photooxidative damage. Pre-treatment of blue-light-exposed A2E containing ARPE-19 cells, with grape skin extracts, inhibited apoptosis, in a dose dependent manner. Knockdown GRP78 blocked the protective effect of grape skin extracts.

read more

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Sunday, 16 September

23:39

Why Scientists Should Reconsider Presenting with TED Mad In America

When I learned that my TEDx talk had been flagged, my initial reaction was here we go again, this work always carries controversy, so whats new?

But then I read the flag, which stated: NOTE FROM TED: Weve flagged this talk, which was filmed at a TEDx event, because it appears to fall outside TEDxs curatorial guidelines. There is limited evidence to support the claims made by this speaker. Please do not look to this talk for medical advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf

I was angry and offended. I couldnt help but take the flag personally, discrediting me as a scientist and challenging my integrity.

Back in October 2014, I had been thrilled and honoured to speak, proud of my TEDx Christchurch (NZ) talk and how well it had done (>900,000 views), and ultimately how many people have benefited from the information.

TED claimed I had stepped outside of the curator guidelines on Science Standards. Understand that TEDx is independent of TED and therefore, even if the local curator is happy with the talk, that doesnt prevent TED from discrediting it, even years later.

I found this hard to fathom as I had spent countless hours fact-checking every statement that I made, contacting other scientists to ensure what I was saying was an accurate reflection of the state of the field, and reworking the talk to ensure it was accessible without losing accuracy.

I had peer reviewed publications to back my statements, as well as dozens of RCTs from other research centres internationally all showing the same thing  nutrients are relevant to good mental health.

So how did this happen? Why was my talk flagged?

The media people I have been dealing with at TED said a complaint had been made and they concluded, after carefully watching my talk, that it appears some assertions made by the speaker have limited support from the medical community.

After sharing with them dozens of peer reviewed publications including an opinion piece I had co-authored in the journal Lancet Psychiatry entitled Nutritional medicine as mainstream in psychiatry, they changed their story and said I made too many sweeping statements.

However, the only example they gave me on sweeping statements was one at 14:50, where I said: Nutrient depleted mothers produce nutrient depleted chi...

21:40

Aspartame: Putting the DIE Into Dieting Since 1981 GreenMedInfo

Aspartame: Putting the DIE Into Dieting Since 1981

Male rat with lymphoma following aspartame treatment.

Pushed globally as a beneficial to dieters since its approval in 1981, accumulating research indicates that aspartame may actually damage the brain and cause cancer, to name but a few of a wide range of adverse health effects consumers risk by using this 'no-calorie' sugar alternative.

read more

20:00

What's In Your Flu Shot? AGE OF AUTISM

By Cathy Jameson Years ago, this video made the rounds as the 2006 flu shot season got under way. As much as I loathe this particular shot and the problems it caused my son post-vaccination, I couldnt help but laugh....

15:00

Dark Choco-Dipped Cherry Bites Recipe Articles

{}{}{}{}{}{}{}{}{}{}{}{}{}{}{}{}{}

Recipe by Pete Evans

Many people just cant end a meal without dessert. After all, a satisfying dessert refreshes your palate and gives your lunch or dinner a sweet ending.

Most people, however, would reach for a bowl of ice cream or a slice of cake to satiate their sweet tooth but why do so when there are healthier dessert options to choose from? Case in point: these delicious cherry bites from Australian celebrity chef Pete Evans, with whom I co-wrote The Fat for Fuel Ketogenic Cookbook.

This easy dessert recipe combines the freshness and tartness of cherries with the bitter taste of raw cacao chocolate and the mild sweetness of coconut flakes, giving you a deep burst of flavor in every bite.

 

Prep time: 15 minutes (plus 30 minutes chilling time)

Cook time: 15 minutes

&nbs...

Introduction to Hiatal Hernia: A Potentially Dangerous Digestive Condition Articles

A hernia is a condition where an organ pushes through an opening that a certain muscle holds in place. There are four different hernias that typically occur in the human body:

  • Inguinal hernia This occurs when intestines push through the inguinal canal, a tubular passage found near the groin area. It helps hold up the testicles in men, and the uterus in women.1
  • Umbilical hernia When the intestines pass through the abdominal wall, a bulge near the belly button occurs. Children younger than 6 months are the largest demographic of this condition, although it usually goes away when theyre a year old.2
  • Incisional hernia This type of hernia can emerge because of a recent abdominal surgery. The intestines may push through the incision scar, or the weakened tissue surrounding it.3
  • Hiatal hernia Hiatal hernia occurs when a part of your stomach protrudes upward through the hiatus, which is an opening in your diaphragm.4

This guide will focus on hiatal hernia. This condition can occur in anyone, from unborn children to those who are approaching middle and senior age. Its symptoms should not be ignored, because they can be very uncomfortable and potentially dangerous.5,6

The Causes of Hiatal Hernia

Hiatal hernia usually occurs in people ages 50 and above, and to those who are overweight or obese. Its exact causes are unknown, but there are a few theories, such as:7

  • Injury or trauma A strong blow to the central chest area can rupture your digestive organs, causing the diaphragm to loosen and allow the stomach to go up.
  • Birth defect Its possible that some people are born with a large hiatus, which will need to be addressed to prevent the hernia from worsening.
  • Constant pressure Certain actions that steadily exert pressure on your chest such as vomiting, coughing and straining while defecating can cause hiatal hernia.

Symptoms of Hiatal Hernia to Watch For

Most of the time, hiatal hernias are minor and asymptomatic, and you can live a full life without needing medical treatment at all. However, those who do develop complications t...

How to End the Autism Epidemic Articles

By Dr. Mercola

In this interview, J.B. Handley, founder of Generation Rescue, discusses autism and what he believes can be done to help turn this tragic trend around. This is also the topic of his book, "How to End the Autism Epidemic."

A Parent's Worst Nightmare

Handley's son has autism, and his personal experience ultimately motivated him to write this book. He describes the family's experience, and what led them to take a nonconventional approach to their son's treatment:

"My wife and I were what I would characterize as very mainstream parents, which meant that when our second son was born in 2002, we basically handed him to our pediatrician and did whatever he told us to do, which meant following the Centers for Disease Control and Prevention's (CDC) recommended [vaccine] schedule.

We started to watch our son decline physically after every vaccine appointment at 2 months, at 4 months, at 6 months and at 12 months. He got eczema. His belly became distended. He had sleep disturbances. He had dark circles under his eyes. We kept going back into the doctor and saying, 'What's going on? What's happening with him? Where is this coming from?'

We could never get a plausible explanation for what was happening. Then, shortly after my son turned 1 year old, he started to decline neurologically. He lost his words. He lost many of his normal mannerisms. He started doing these really unusual behaviors.

He started craving certain foods all these things that somebody like you knows are red flags for a child heading towards autism. But at the time, we were ignorant to this and our pediatrician didn't help us at all.

We were living in Northern California. We took our son to University of California San Francisco (UCSF) where they diagnosed him with severe autism. At the same time, we visited a Defeat Autism Now! (DAN!) doctor in Pleasanton Dr. Lynne Mielke.

We were presented with two completely different worlds. At UCSF, autism was genetic. It was lifelong. He was likely to be institutionalized. There was nothing we could do about it, except to prepare ourselves.

But in Pleasanton, thirty miles away, autism was triggered by vaccines. It was an environmental illness. If you vetted the diet and started to do things differently, some of these children recovered completely. Here's my wife and I, both educated at Stanford, both very mainstream, and we're p...

08:18

Indole 3 Carbinol in Broccoli Shows Major Healing Potential Natural Blaze

By Dr. Mercola

Science has repeatedly proven that food is a profoundly effective medicine that can activate many healthy nuclear transcription factors in your body. Broccoli and other cruciferous vegetables, for example, have been repeatedly shown to be one of natures most valuable health-promoting foods, capable of preventing a number of common health issues.

Cruciferous veggies, which include broccoli, cabbage, collards, Brussels sprouts, cauliflower, kale and bok choi, just to name a few, contain several plant compounds that are important for optimal health, including powerful chemoprotective compounds.

One of the most well-known of these is sulforaphane, an organic sulfur. Studies have shown sulforaphane supports normal cell function and division while causing apoptosis (programmed cell death) in colon,1 liver,2 prostate,3 breast...

07:44

Coconut Oil Secrets for Beautiful Glowing Skin and Shiny Hair Healthy and Natural World

Coconut oil is so versatile and is a staple in many kitchens. Coconut oil has been a common ingredient in Asian and Pacific households for ages, but received in the past a bad reputation in Western society due to its saturated fat content. But now it is gaining popularity in the West and is recognized for its health benefits (and you can read my previous article about coconut oils many health benefits).

However apart from cooking with coconut oil or ingesting it, you can use coconut oil for your skin and hair. Remember, unrefined, organic, cold-pressed virgin coconut oil is your best option (and should always be used when taken internally).

Virgin coconut oil is processed without chemicals that damage its natural compounds which makes it so good for your hair and skin. You can find it in many supermarkets, health food stores or online.

In this article I will show you versatile ways to use coconut oil on your skin and face as well as your hair maybe its time to replace your expensive commercial hair and skin products with a cheaper and natural alternative youve got nothing to lose.

Coconut Oil for Shiny hair

Coconut oil contains medium chain fatty acids (MCT), in which lauric acid is the most well-known of them. These fatty acids nourish and moisturize the scalp and hair. Virgin coconut oil can strengthen, protect, rejuvenate, and give a beautiful shine to your hair.

Coconut oil is solid at cold temperatures but melts at 76 degrees F (24.5 C) or above. So if your coconut oil is solid, measure a few tablespoons of coconut oil (depends on your hair length) in a cup and heat in the microwave until it has melted (or place the cup in a bowl of warm water to melt it).

Coconut oil for damaged hair

A study published in 2003 in the Journal of Cosmetic Science found that coconut oil was the best in preventing damage to the hair shaft when compared with sunflower oil and mineral oil. The study found that coconut oil is a rich source of lauric acid and has a high affinity for hair proteins. Because of its molecular properties, it can also penetrate deep inside the hair shaft.

So if you have damaged hair, massage your scalp with coconut oil to heal the damage that is caused to your hair.

Coconut oil for dry and frizzy Hair

If your hair is frizzy and dry, you can use some coconut oil to moisturize and smooth the hair to prevent frizz and tame your hair. This is espe...

06:46

L-type calcium channel 1D subunit may be involved in blue light induced damage on human retinal pigment epithelial cells. GreenMedInfo

PMID:  Zhonghua Yan Ke Za Zhi. 2014 Nov ;50(11):814-9. PMID: 25582206 Abstract Title:  [The effect of blue light on human retinal pigment epithelium cells1D subunit protein expression and vascular endothelial growth factor and basic fibroblast growth factor secretion in vitro]. Abstract:  OBJECTIVE: To investigate the effect of blue light on human retinal pigment epithelium (RPE)1D subunit protein expression and its relationship with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) secretion in vitro.METHODS: The fourth generation cultured human RPE cells in vitro were randomly divided into 4 groups, group A (control), group B (exposure to blue light), group C (exposure to blue light+nifedipine), group D [exposure to blue light+(-)Bay K8644]. Cells were exposed to blue light (2 000 500) lx for 6 hours, and cells culture completed 24 hours later. VEGF and bFGF concentration were assayed by enzyme linked immunosorbent assay (ELISA). Real-time polymerase chain reaction was used to analysis L-type calcium channel 1D subunit mRNA expression. Western blot was used to examine the protein expression of L-type calcium channel 1D subunit. Analysis of variance was used to compare the difference of 1D subunit mRNA and protein expression, VEGF and bFGF concentration between groups. Correlation analysis was used to show the relationship between 1D subunit protein expressionand concentration of VEGF and bFGF.RESULTS: (1) There is significant statistically difference in the population mean of VEGF and bFGF concentration in four groups (F = 99.441, 21.310, P = 0.000,0.000) . VEGF and bFGF concentration in group B (3 281.51 251.73, 1 346.81 62.27) and group D (3 808.01 94.01, 1 485.82 108.97) was higher than it was in group A (2 401.09 228.07, 1 232.42 65.41) , which was statistically different (P = 0.000, 0.000, 0.019, 0.000). And it was higher in group D (3 808.01 94.01, 1 485.82 108.97) compared with group B (3 281.51 251.73, 1 346.81 62.27) (P = 0.000, 0.006). While, it was lower in group C (1 927.28 143.11, 1 149.39 62.99) than it was in group B (3 281.51 251.73, 1 346.81 62.27) (P = 0.000, 0.000) . (2) The mean of mRNA expression of 1D subunit between four groupswas statistically significant (F = 50.320, P = 0.000) . It was higher in group B (210 23) , group D (478 80) and group C (232 14) than group A (100 20). It was statistically significant different (P = 0.023, 0.006, 0.010). And it was higher in group D (478 80) than group B (210 23)and C (232 14) (P = 0.032, 0.039). (3) There was statistically significant difference in the expression of L-type calcium channel 1D subunit protein in four groups (F = 1 940.363, P = 0.000) . It was significantly higher (P = 0.000,0.000) in group B (0.974 2 0.014 7) and group...

06:40

Phototoxicity of LEDs on the retina is characterized by a strong damage of photoreceptors and by the induction of necrosis. GreenMedInfo

PMID:  Free Radic Biol Med. 2015 Jul ;84:373-384. Epub 2015 Apr 8. PMID: 25863264 Abstract Title:  Retinal damage induced by commercial light emitting diodes (LEDs). Abstract:  Spectra of"white LEDs"are characterized by an intense emission in the blue region of the visible spectrum, absent in daylight spectra. This blue component and the high intensity of emission are the main sources of concern about the health risks of LEDs with respect to their toxicity to the eye and the retina. The aim of our study was to elucidate the role of blue light from LEDs in retinal damage. Commercially available white LEDs and four different blue LEDs (507, 473, 467, and 449nm) were used for exposure experiments on Wistar rats. Immunohistochemical stain, transmission electron microscopy, and Western blot were used to exam the retinas. We evaluated LED-induced retinal cell damage by studying oxidative stress, stress response pathways, and the identification of cell death pathways. LED light caused a state of suffering of the retina with oxidative damage and retinal injury. We observed a loss of photoreceptors and the activation of caspase-independent apoptosis, necroptosis, and necrosis. A wavelength dependence of the effects was observed. Phototoxicity of LEDs on the retina is characterized by a strong damage of photoreceptors and by the induction of necrosis.

read more

06:36

Evidence for the role of blue light in the development of uveal melanoma. GreenMedInfo

PMID:  J Ophthalmol. 2015 ;2015:386986. Epub 2015 May 17. PMID: 26075084 Abstract Title:  Evidence for the Role of Blue Light in the Development of Uveal Melanoma. Abstract:  Uveal melanoma is the most common malignancy of the adult eye. Although it is a relatively infrequent tumor, clinical prognosis is often poor owing to a high incidence of aggressive metastatic disease, for which there are limited treatment options. Little is known about the etiology of this condition, although several risk factors have been identified. Unlike cutaneous melanoma, however, ultraviolet radiation does not figure prominently among these risk factors. In this review, we focus on an associated form of visible electromagnetic radiation, high-energy short-wave (blue) light, a causative agent in various forms of age-related retina damage, as a previously overlooked risk factor in uveal melanoma development and progression. Finally, we discuss the impact of these data on contemporary ocular therapy, particularly the debate surrounding the filtering capabilities of intraocular lenses used to replace dysfunctional crystalline lenses during cataract surgery.

read more

06:30

Pupillary responses to high-irradiance blue light correlate with glaucoma severity. GreenMedInfo

PMID:  Ophthalmology. 2015 Sep ;122(9):1777-85. PMID: 26299721 Abstract Title:  Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity. Abstract:  PURPOSE: To evaluate whether a chromatic pupillometry test can be used to detect impaired function of intrinsically photosensitive retinal ganglion cells (ipRGCs) in patients with primary open-angle glaucoma (POAG) and to determine if pupillary responses correlate with optic nerve damage and visual loss.DESIGN: Cross-sectional study.PARTICIPANTS: One hundred sixty-one healthy controls recruited from a community polyclinic (55 men; 151 ethnic Chinese) and 40 POAG patients recruited from a glaucoma clinic (22 men; 35 ethnic Chinese) 50 years of age or older.METHODS: Subjects underwent monocular exposure to narrowband blue light (469 nm) or red light (631 nm) using a modified Ganzfeld dome. Each light stimulus was increased gradually over 2 minutes to activate sequentially the rods, cones, and ipRGCs that mediate the pupillary light reflex. Pupil diameter was recorded using an infrared pupillography system.MAIN OUTCOME MEASURES: Pupillary responses to blue light and red light were compared between control subjects and those with POAG by constructing dose-response curves across a wide range of corneal irradiances (7-14 log photons/cm(2) per second). In patients with POAG, pupillary responses were evaluated relative to standard automated perimetry testing (Humphrey Visual Field [HVF]; Carl Zeiss Meditec, Dublin, CA) and scanning laser ophthalmoscopy parameters (Heidelberg Retinal Tomography [HRT]; Heidelberg Engineering, Heidelberg, Germany).RESULTS: The pupillary light reflex was reduced in patients with POAG only at higher irradiance levels, corresponding to the range of activation of ipRGCs. Pupillary responses to high-irradiance blue light associated more strongly with disease severity compared with responses to red light, with a significant linear correlation observed between pupil diameter and HVF mean deviation (r = -0.44; P = 0.005) as well as HRT linear cup-to-disc ratio (r = 0.61; P

read more

06:22

Preventive effect of Vaccinium uliginosum L. extract and its fractions on age-related macular degeneration and its action mechanisms. GreenMedInfo

PMID:  Arch Pharm Res. 2016 Jan ;39(1):21-32. Epub 2015 Nov 20. PMID: 26589689 Abstract Title:  Preventive effect of Vaccinium uliginosum L. extract and its fractions on age-related macular degeneration and its action mechanisms. Abstract:  Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among the elderly. Although the pathogenesis of this disease remains still obscure, several researchers have report that death of retinal pigmented epithelium (RPE) caused by excessive accumulation of A2E is crucial determinants of AMD. In this study, the preventive effect of Vaccinium uliginosum L. (V.U) extract and its fractions on AMD was investigated in blue light-irradiated human RPE cell (ARPE-19 cells). Blue light-induced RPE cell death was significantly inhibited by the treatment of V.U extract or its fraction. To identify the mechanism, FAB-MS analysis revealed that V.U inhibits the photooxidation of N-retinyl-N-retinylidene ethanolamine (A2E) induced by blue light in cell free system. Moreover, monitoring by quantitative HPLC also revealed that V.U extract and its fractions reduced intracellular accumulation of A2E, suggesting that V.U extract and its fractions inhibit not only blue light-induced photooxidation, but also intracellular accumulation of A2E, resulting in RPE cell survival after blue light exposure. A2E-laden cell exposed to blue light induced apoptosis by increasing the cleaved form of caspase-3, Bax/Bcl-2. Additionally, V.U inhibited by the treatment of V.U extract or quercetin-3-O-arabinofuranoside. These results suggest that V.U extract and its fractions have preventive effect on blue light-induced damage in RPE cells and AMD.

read more

06:18

Effects of blue light on the circadian system and eye physiology. GreenMedInfo

PMID:  Mol Vis. 2016 ;22:61-72. Epub 2016 Jan 24. PMID: 26900325 Abstract Title:  Effects of blue light on the circadian system and eye physiology. Abstract:  Light-emitting diodes (LEDs) have been used to provide illumination in industrial and commercial environments. LEDs are also used in TVs, computers, smart phones, and tablets. Although the light emitted by most LEDs appears white, LEDs have peak emission in the blue light range (400-490 nm). The accumulating experimental evidence has indicated that exposure to blue light can affect many physiologic functions, and it can be used to treat circadian and sleep dysfunctions. However, blue light can also induce photoreceptor damage. Thus, it is important to consider the spectral output of LED-based light sources to minimize the danger that may be associated with blue light exposure. In this review, we summarize the current knowledge of the effects of blue light on the regulation of physiologic functions and the possible effects of blue light exposure on ocular health.

read more

06:12

Establishment of a blue light damage model of human retinal pigment epithelial cells in vitro. GreenMedInfo

PMID:  Genet Mol Res. 2016 Jun 24 ;15(2). Epub 2016 Jun 24. PMID: 27420965 Abstract Title:  Establishment of a blue light damage model of human retinal pigment epithelial cells in vitro. Abstract:  To establish a blue-light damage model of human retinal pigment epithelium (RPE). Fourth-generation human RPE cells were randomly divided into two groups. In group A, cells were exposed to blue light (2000 500 lux) for 0 (control), 3, 6, 9, and 12 h, and cell culture was stopped after 12 h. In group B, cells were exposed to blue light at the same intensity and time periods, but cell culture was stopped after 24 h. TdT-mediated dUTP nick-end labeling (TUNEL) assay was performed to determine the mostsuitable illuminating time with apoptotic index. Flow cytometry was used to determine apoptotic ratio of RPEs. In group A, the apoptotic index of cells that received 6, 9 and 12 h of blue light was higher than that of control. The apoptotic index of cells receiving 9 and 12 h was higher than that of 6 h (P = 0.000). In group B, the apoptotic index and RPE cell apoptosis ratio of cells exposed to 6, 9 and 12 h of blue light were higher than that of 3 h (P = 0.000); and cells receiving 9 and 12 h had higher values than that of 6 h. This study demonstrated that the best conditions to establish ablue light damage model of human retinal pigment epithelial cells in vitro are 2000 500 lux light intensity for 6 h, with 24 h of cell culture post-exposure.

read more

06:10

Feds go after holistic doctor for doing chelation therapy on patients Health Nut News

Ringgold doctor, Dr. Charles C. Adams, who was treating patients suffering from heavy metal poisoning and billing Medicare for their effective medical treatment is being charged by our lovely government (a.k.a. the Feds). In a Medicare fraud lawsuit filed Tuesday in U.S. district court in Atlanta, federal prosecutors alleged that the patients didnt need the chelation []

The post Feds go after holistic doctor for doing chelation therapy on patients appeared first on Health Nut News.

06:07

Overexposure to blue light with short wavelengths can induce oxidative damage and apoptosis to the cornea. GreenMedInfo

PMID:  PLoS One. 2016 ;11(8):e0161041. Epub 2016 Aug 12. PMID: 27517861 Abstract Title:  Influence of Light Emitting Diode-Derived Blue Light Overexposure on Mouse Ocular Surface. Abstract:  PURPOSE: To investigate the influence of overexposure to light emitting diode (LED)-derived light with various wavelengths on mouse ocular surface.METHODS: LEDs with various wavelengths were used to irradiate C57BL/6 mice at an energy dose of 50 J/cm2, twice a day, for 10 consecutive days. The red, green, and blue groups represented wavelengths of 630 nm, 525 nm, and 410 nm, respectively. The untouched group (UT) was not exposed to LED light and served as the untreated control. Tear volume, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured on days 1, 3, 5, 7, and 10. Levels of interferon (IFN)-, interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)- were measured in the cornea and conjunctiva using a multiplex immunobead assay at day 10. Levels of malondialdehyde (MDA) were measured with an enzyme-linked immunosorbent assay. Flow cytometry, 2'7'-dichlorofluorescein diacetate (DCF-DA) assay, histologic analysis, immunohistochemistry with 4-hydroxynonenal, and terminal deoxynucleotidyl transferase-mediated dUTP-nick end labeling (TUNEL) staining were also performed.RESULTS: TBUT of the blue group showed significant decreases at days 7 and 10, compared with the UT and red groups. Corneal fluorescein staining scores significantly increased in the blue group when compared with UT, red, and green groups at days 5, 7, and 10. A significant increase in the corneal levels of IL-1 and IL-6 was observed in the blue group, compared with the other groups. The blue group showed significantly increased reactive oxygen species production in the DCF-DA assay and increased inflammatory T cells in the flow cytometry. A significantly increased TUNEL positive cells was identified inthe blue group.CONCLUSIONS: Overexposure to blue light with short wavelengths can induce oxidative damage and apoptosis to the cornea, which may manifest as increased ocular surface inflammation and resultant dry eye.

read more

05:57

The Nrf2 pathway plays an important role in protecting retinal pigment epithelium cells against blue light-induced oxidative stress. GreenMedInfo

n/a PMID:  Oxid Med Cell Longev. 2016 ;2016:8694641. Epub 2016 Sep 27. PMID: 27774118 Abstract Title:  Nuclear Factor (Erythroid-Derived)-Related Factor 2-Associated Retinal Pigment Epithelial Cell Protection under Blue Light-Induced Oxidative Stress. Abstract:  . It is a matter of increasing concern that exposure to light-emitting diodes (LED), particularly blue light (BL), damages retinal cells. This study aimed to investigate the retinal pigment epithelium (RPE) damage caused by BL and to elucidate the role of nuclear factor (erythroid-derived)-related factor 2 (Nrf2) in the pathogenesis of BL-induced RPE damage.. ARPE-19, a human RPE cell line, and mouse primary RPE cells from wild-type andknockout () mice were cultured under blue LED exposure (intermediate wavelength, 450nm). Cell death rate and reactive oxygen species (ROS) generation were measured. TUNEL staining was performed to detect apoptosis. Real-time polymerase chain reaction was performed onmRNA, and western blotting was performed to detect Nrf2 proteins in the nucleus or cytoplasm of RPE cells.. BL exposure increased cell death rate and ROS generation in ARPE-19 cells in a time-dependent manner; cell death was caused by apoptosis. Moreover, BL exposure inducedmRNA upregulation and Nrf2 nuclear translocation in RPE. Cell death rate was significantly higher in RPE cells frommice than from wild-type mice.. The Nrf2 pathway plays an important role in protecting RPE cells against BL-induced oxidative stress.

05:45

Immunomodulatory effect of flavonoids of blueberry leaves via the NF-B signal pathway in LPS-Stimulated RAW 264.7 cells. GreenMedInfo

PMID:  J Immunol Res. 2017 ;2017:5476903. Epub 2017 Dec 27. PMID: 29445755 Abstract Title:  Immunomodulatory Effect of Flavonoids of Blueberry (L.) Leaves via the NF-B Signal Pathway in LPS-Stimulated RAW 264.7 Cells. Abstract:  Objective: This study aimed to explore the immunoregulatory effect of flavonoids of blueberry (L.) leaves (FBL).Methods: The flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-Tof-MS). The immunoregulatory effect and possible regulatory mechanisms of FBL were investigated in lipopolysaccharide- (LPS-) induced RAW 264.7 cells.Results: According to the results of UPLC/Q-Tof-MS, nine flavonoids of blueberry leaves were identified. FBL showed a significant reduction in the production of TNF-in LPS-stimulated RAW 264.7 cells. FBL significantly decreased the expression of NF-B p65 and P-NF-B p65 in LPS-induced RAW 264.7 cells in a dose-dependent manner.Conclusion: Our study showed the immunoregulatory effect of FBL through the suppression of TNF-via the NF-B signal pathway.

read more

05:44

Cannabis leads to better and more frequent sex according to science Health Nut News

There are those who think that everything is better when youre high; food tastes better, music sounds better, and, of course, sex definitely feels better, but is there any way to actually prove that? Like, scientifically? Apparently, yes. Scientists at Stanford University (who had nothing better to do?) conducted a study to confirm that weed takes sex []

The post Cannabis leads to better and more frequent sex according to science appeared first on Health Nut News.

05:23

Tinted glasses may provide significant protection against potential blue-light-induced photo-oxidative damage in retinal pigment epithelial cells. GreenMedInfo

PMID:  Ophthalmic Res. 2017 ;57(2):118-124. Epub 2016 Nov 24. PMID: 27880954 Abstract Title:  The Protective Effect of Brown-, Gray-, and Blue-Tinted Lenses against Blue LED Light-Induced Cell Death in A2E-Laden Human Retinal Pigment Epithelial Cells. Abstract:  A2E-laden ARPE-19 cells were exposed to a blue light to induce cytotoxicity, in order to investigate the protective effects of various tinted ophthalmic lenses against photo-induced cytotoxicity in human retinal pigment epithelial (RPE) cells laden with A2E, known to be among the etiologies of age-related macular degeneration (AMD). Different-colored tinted lenses with varying levels of tint and different filtering characteristics, such as polarized, blue-cut, and photochromatic lenses, were placed over the cells, and the protective efficacies thereof were evaluated by lactate dehydrogenase assay. When tinted lenses were placed over ARPE-19 cells, there were different reductions in cytotoxicity according to the colors and tint levels. The level of protection afforded by brown-tinted lenses was 6.9, 36.1, and 49% with a tint level of 15, 50, and 80%, respectively. For gray-tinted lenses, the protective effect was 16.3, 35, and 43.4% for the corresponding degree of tint, respectively. In the case of blue-tinted lenses, a protective effect of 20% was observed with 80% tinted lenses, but 15 and 50% tinted lenses provided no significant protection. In addition, photochromic lenses showed a protective effect but blue-cut lenses and polarized lenses provided no significant protection. Tinted lenses significantly reduced cytotoxicity in RPE cells irradiated with blue light. The protection was more efficient in lenses with a brown or gray tint than in blue-tinted lenses. Tinted glasses may provide significant protection against potential blue-light-induced photochemical and photo-oxidative damage in RPE cells.

read more

05:17

Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light. GreenMedInfo

PMID:  Nutr Res. 2016 Dec ;36(12):1402-1414. Epub 2016 Nov 18. PMID: 27993192 Abstract Title:  Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light in A2E-laden ARPE19 cell cultures and mice. Abstract:  Polyphenols exert beneficial effects on vision. We hypothesized that polyphenol components of Vaccinium uliginosum L. (V.U.) extract protect retinal pigment epithelial (RPE) cells against blue light-induced damage. Our aim was to test extracts containing polyphenol components to ascertain effects to reduce damage against blue light in RPEs. We measured the activity in fractions eluted from water, ethanol, and HP20 resin (FH), and found that the FH fraction had the highest beneficial activity. We isolated the individual active compounds from the FH fraction using chromatographic techniques, and found that FH contained flavonoids, anthocyanins, phenyl propanoids, and iridoids. Cell cultures of A2E-laden ARPE-19 exposed to blue light after treatment with V.U. extract fractions and their individual constituents indicated improvement. V uliginosum L extract fractions and constituent compounds significantly reduced A2E photo-oxidation-induced RPE cell death and inhibited intracellular A2E accumulation. Furthermore, Balb/c male mice were exposed to blue light at 10000 lux for 1 h/d for 2 weeks to induce retinal damage. One week after the final blue light exposure, retinal damage evaluated revealed that the outer nuclear layer thickness and nuclei count were improved. Histologic examination of murine photoreceptor cells demonstrated that FH, rich in polyphenols, inhibited the loss of outer nuclear layer thickness and nuclei. Our findings suggest that V.U. extract and eluted fractions are a potential source of bioactive compounds that potentially serve a therapeutic approach for age-related macular degeneration.

read more

05:13

Geoengineering Watch Global Alert News, September 15, 2018, #162 Geoengineering Watch

Dane Wigington GeoengineeringWatch.org The mainstream media focus has now transitioned from record wildfires to record cyclones, the weather manipulation continues unabated. What agendas are being carried out by the weather-makers? Overall biosphere degradation from countless forms of highly destructive human activity (with climate engineering at the top of the list) continues to take its toll on Earth's life

05:13

Watch the groundbreaking video-series, Depression & Anxiety Secrets FREE online 24th Sept 1st Oct Health Nut News

Can Anxiety & Depression Be Cured? Naturally!? The World Needs a Better Solution For Depression & Anxiety Depression and anxiety are at epidemic proportions. Anxiety disorders are the most common mental illness in the U.S., affecting almost 20% of the adult population, and depression affects over 18 million adults (one in ten people). And the conventional []

The post Watch the groundbreaking video-series, Depression & Anxiety Secrets FREE online 24th Sept 1st Oct appeared first on Health Nut News.

05:06

Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage. GreenMedInfo

PMID:  Toxicol Sci. 2017 05 1 ;157(1):196-210. PMID: 28184904 Abstract Title:  Editor's Highlight: Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis. Abstract:  Blue light-induced phototoxicity plays an important role in retinal degeneration and might cause damage as a consequence of smartphone dependency. Here, we investigated the effects of periodic exposure to blue light-emitting diode in a cell model and a rat retinal damage model. Retinal pigment epithelium (RPE) cells were subjected to blue light in vitro and the effects of blue light on activation of key apoptotic pathways were examined by measuring the levels of Bcl-2, Bax, Fas ligand (FasL), Fas-associated protein with death domain (FADD), and caspase-3 protein. Blue light treatment of RPE cells increased Bax, cleaved caspase-3, FasL, and FADD expression, inhibited Bcl-2 and Bcl-xL accumulation, and inhibited Bcl-2/Bax association. A rat model of retinal damage was developed with or without continuous or periodic exposure to blue light for 28 days. In this rat model of retinal damage, periodic blue light exposure caused fundus damage, decreased total retinal thickness, caused atrophy of photoreceptors, and injured neuron transduction in the retina.

read more

05:03

NSAID pain killers linked to irregular heartbeat Health Nut News

Non-steroidal anti-inflammatory drugs or NSAIDs are among the most widely used pain killers in the world. In the United States, more than 70 million prescriptions for NSAIDs are written each year. If you include over-the-counter (OTC) NSAIDs such as ibuprofen and aspirin, more than 30 billion doses of NSAIDs are used annually to relieve pain associated with everything []

The post NSAID pain killers linked to irregular heartbeat appeared first on Health Nut News.

04:49

A case report of damage to the macula associated with LED-derived blue laser exposure. GreenMedInfo

PMID:  BMC Ophthalmol. 2017 Apr 24 ;17(1):49. Epub 2017 Apr 24. PMID: 28438153 Abstract Title:  Damage to the macula associated with LED-derived blue laser exposure: A case report. Abstract:  BACKGROUND: Light emitting diodes laser is emerging as an important source of light replacing conventional lights. It is widely used for illumination in the bar where young people love to go. But not everyone knows about the light damage to the eye especially to the macula. In this article, we report the case of a macular damage induced by LED-derived blue laser in a bar, studied with optical coherence tomography (OCT) to evaluate the retinal lesion and multifocal electroretinography (mfERG) to evaluate functional damage.CASE PRESENTATION: Four days after the photo injury to the right eye, the visual acuity was 0.5. Funduscopy revealed a round red lesion in the macula of the right eye. Fluorescein angiography (FA) revealed no leakage. OCT revealed a deficiency in the center of the fovea. MfERG revealed a reduction of the peak value in the right eye compared to the left eye. One month later, although the vision was 1.0 in the right eye, OCT revealed a hyporeflectivity of the ellipsoid zone. MfERG still showed a reduction of the peak value in the right eye compared to the left eye.CONCLUSION: We believe that general knowledge about laser injuries to the eye should be realized widely. We also think in cases of macular laser damage, the recovery of vision can not demonstrate the recovery of the function of photoreceptors.

read more

02:09

Did You Ever Stop Taking Antipsychotics? Mad In America

1.6% of the US population more than 5 million people currently takes antipsychotic medication such as Zyprexa, Geodon, Risperdal or Haldol, according to a 2017 review in the Journal of the American Medical Association; and antipsychotics are among the top grossing pharmaceuticals sold in the US today. Worldwide the pattern is similar, with antipsychotic drugs considered not only a necessary treatment for psychosis but now also used to treat bipolar mania, anxiety, depression, dementia, learning disability, and even insomnia.

If you are one of the people taking antipsychotics, or you used to take them, chances are you werent given a clear picture of what these drugs are all about before being prescribed, much less what your options were for getting off of them. More properly understood as tranquilizers closer to what they were referred to when first introduced antipsychotics can be useful to suppress some kinds of behavior, emotions, and perceptions. Clinicians, however, routinely fail in their responsibility to alert patients to a clear understanding of benefits versus risks, how to know when to start and when to stop taking the drugs, how to come off, the downsides of being on the drugs, and even how they can sometimes make things worse in the long run. Ive consistently seen this huge gap in knowledge and patient education in my more than 15 years working as a mental health advocate, clinician and now researcher, speaking with patients, former patients, families and professionals in more than 30 countries and online. Antipsychotics are big business, professionals are often at a loss as to how to help people going through disturbing experiences, there is a huge fear to speak openly, the voices of patients and former patients are crowded out of the equation there are many reasons for this lack of real education and real informed consent around antipsychotic medication prescription.

To address this gap in knowledge and help get a clearer picture of the role of antipsychotics in peoples lives, I teamed up with Maastricht University School for Mental Health and Neuroscience in The Netherlands on a world study on antipsychotic medication withdrawal. This June we launched an anonymous online survey about withdrawal. People over the age of 18, who have taken antipsychotic medications, and who have stopped taking them or tried to stop can complete the anonymous survey online at www.antipsychoticwithdrawalsurvey.com. Currently available in English, Spanish, Dutch, and Italian translations, the survey also has additional language translations underway and available soon.

I was drawn to do my doctorate at Maastricht University because of the research focus of European graduate schools, and through the work of Dr. Jim van Os, my study supervisor who is known internationally f...

01:05

BPA-Free Plastics Disrupt Fertility Natural Blaze

By Andy Coghlan

Many plastic bottles are sold as BPA-free meaning they dont contain bisphenol A, an ingredient known to disrupt reproduction in mice. But now it seems that the additives used in place of BPA are potentially just as harmful.

The discovery could mean that the replacements, such as bisphenol S (BPS), might potentially affect people if they leach out into food or drink.

Theres no evidence yet that this happens. But the new results from mice suggest that if there is a risk, it may match that posed by BPA itself. Several of these bisphenols induce changes in the germline similar to those we reported previously for BPA, says Patricia Hunt of Washington State University in Pullman, who helped draw attention to the BPA problem 20 years ago.

Hunts latest discovery emerged in the same way as her BPA findings. As before, she noticed that mice kept in certain plastic cages began to show reproductive problems, such as abnormal eggs and low sperm counts. As with BPA, she found the inner surfaces to which mice were exposed were contaminated, this time with BPS that had leached out from the plastic.

Screening CellsHunt i...

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Saturday, 15 September

23:47

Weekend reads: Top researchers resign over publishing issues; organized crime meets publishing; infamous fraudster rides in on a horse Retraction Watch

Before we present this weeks Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured a look at authors who publish once every five days, Continue reading Weekend reads: Top researchers resign over publishing issues; organized crime meets publishing; infamous fraudster rides in on a horse

23:02

Video: The Kavanaugh Circus Front Page - The Health Wyze Report

Since the nomination of Brett Kavanaugh for Supreme Court Justice, Democrats have used every tactic imaginable to delay or prevent his appointment. From generic picket signs and paid protesters to vague accusations of sexual misconduct; there is no stooping too low. Kavanaugh was a nominee who was supposed to be a non-controversial shoo-in, but in today's obstructionist climate, there is truly no such thing.

You may watch this on YouTube if there are any problems watching the video at this site.

15:41

N-acetylcysteine protected against blue LED light-induced retinal damage in a dose-dependent manner. GreenMedInfo

PMID:  Biol Pharm Bull. 2017 ;40(8):1219-1225. PMID: 28769003 Abstract Title:  The Involvement of the Oxidative Stress in Murine Blue LED Light-Induced Retinal Damage Model. Abstract:  The aim of study was to establish a mouse model of blue light emitting diode (LED) light-induced retinal damage and to evaluate the effects of the antioxidant N-acetylcysteine (NAC). Mice were exposed to 400 or 800lx blue LED light for 2h, and were evaluated for retinal damage 5d later by electroretinogram amplitude and outer nuclear layer (ONL) thickness. Additionally, we investigated the effect of blue LED light exposure on shorts-wave-sensitive opsin (S-opsin), and rhodopsin expression by immunohistochemistry. Blue LED light induced light intensity dependent retinal damage and led to collapse of S-opsin and altered rhodopsin localization from inner and outer segments to ONL. Conversely, NAC administered at 100 or 250mg/kg intraperitoneally twice a day, before dark adaptation and before light exposure. NAC protected the blue LED light-induced retinal damage in a dose-dependent manner. Further, blue LED light-induced decreasing of S-opsin levels and altered rhodopsin localization, which were suppressed by NAC. We established a mouse model of blue LED light-induced retinal damage and these findings indicated that oxidative stress was partially involved in blue LED light-induced retinal damage.

read more

15:32

High-energy blue light from visual display terminals can be a risk factor in the ocular surface damage. GreenMedInfo

PMID:  Zhonghua Yan Ke Za Zhi. 2018 Jun 11 ;54(6):426-431. PMID: 29895116 Abstract Title:  [Influence of blue light from visual display terminals on human ocular surface]. Abstract:  To investigate the influence of blue light from visual display terminals (VDTs) on human ocular surface.Prospective intervention test Thirty volunteers were recruited to watch videos on the same VDT in a dark environment, about 40 cm from the screen. Volunteers were supposed to watch videos in the night shift mode that reduces the amount of blue light for 1 hour. At the same time of the second day, they watched the same videos on the VDT in the normal mode for 1 hour. Tear film break-up time (BUT), corneal fluorescein staining scores, lipid layer thickness (LLT), times of blinking in 19.1 seconds and the ratio of partial blinking in 19.1 seconds were measured before and after each watching. Meanwhile, volunteers were asked to complete a questionnaire about their subjective experience after watching.BUT, corneal fluorescein staining scores and LLT showed no significant decreases in the volunteers after they watched videos on the VDT in the night shift mode [BUT before watching: (8.083.15)s, BUT after watching in the night shift mode: (5.312.49)s,-0.52,0.05], but there were significant decreases after they watched videos in the normal mode [BUT after watching in the normal mode: (3.351.95) s,2.40,0.05]. At the same time, there was a significant difference between night shift mode and normal mode[BUT after watching in the night shift mode (5.312.49)s, BUT after watching in the normal mode: (3.351.95)s,3.67,0.05). Times of blinking and the ratio of partial blinking in 19.1 seconds were increased modestly after watching in 2 different modes, but there was no significant difference(times of blinking after watching in the night shift mode were 5.553.27, times of blinking after watching in the normal mode were 5.933.59,-0.92,0.05). The questionnaire results showed that 70.0%(21) of the volunteers reported mild discomfort including eye dryness, itching, pain, foreign body sensation, redness and asthenopia, 46.7%(14) reported no difference between the 2 modes, 36.7%(11) preferred the night shift mode, 16.6%(5) felt better with the normal mode, and 80.0%(24) would like to try the night shift mode in their daily life.Use of VDTs for a short period of time can lower the stability of tear film. The night shift mode may cause less damage to the ocular surface than the normal mode. High-energy blue light from VDTs can be a risk factor in the ocular surface damage, but the damage is reversible.-.

read more

15:23

Blue blocking glasses are effective and feasible as addon treatment for bipolar mania. GreenMedInfo

PMID:  Bipolar Disord. 2016 05 ;18(3):221-32. PMID: 27226262 Abstract Title:  Blue-blocking glasses as additive treatment for mania: a randomized placebo-controlled trial. Abstract:  OBJECTIVES: The discovery of the blue lightsensitive retinal photoreceptor responsible for signaling daytime to the brain suggested that light to the circadian system could be inhibited by using blue-blocking orange tinted glasses. Blue-blocking (BB) glasses are a potential treatment option for bipolar mania. We examined the effectiveness of BB glasses in hospitalized patients with bipolar disorder in a manic state.METHODS: In a single-blinded, randomized, placebo-controlled trial (RCT), eligible patients (with bipolar mania; age 18-70 years) were recruited from five clinics in Norway. Patients were assigned to BB glasses or placebo (clear glasses) from 6 p.m. to 8 a.m. for 7 days, in addition to treatment as usual. Symptoms were assessed daily by use of the Young Mania Rating Scale (YMRS). Motor activity was assessed by actigraphy, and compared to data from a healthy control group. Wearing glasses for one evening/night qualified for inclusion in the intention-to-treat analysis.RESULTS: From February 2012 to February 2015, 32 patients were enrolled. Eight patients dropped out and one was excluded, resulting in 12 patients in the BB group and 11 patients in the placebo group. The mean decline in YMRS score was 14.1 [95% confidence interval (CI): 9.7-18.5] in the BB group, and 1.7 (95% CI: -4.0 to 7.4) in the placebo group, yielding an effect size of 1.86 (Cohen's d). In the BB group, one patient reported headache and two patients experienced easily reversible depressive symptoms.CONCLUSIONS: This RCT shows that BB glasses are effective and feasible as add-on treatment for bipolar mania.

read more

15:16

Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice. GreenMedInfo

PMID:  Exp Eye Res. 2018 Jul 21 ;177:1-11. Epub 2018 Jul 21. PMID: 30040948 Abstract Title:  Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice. Abstract:  To determine the characteristics of the damages of the retinal pigment epithelium (RPE) and photoreceptors of pigmented mice induced by exposure to blue light emitting diode (LED) light, and to determine the mechanisms causing the damages. Exposure to blue LED light for 3 days induced retinal damage, and the characteristics of the damage differed from that induced by white fluorescent light exposure. Ophthalmoscopy showed that blue LED exposure for 3 days induced white spots on the retina, and histological examinations showed materials accumulated at the IS/OS junction of the photoreceptors. The accumulated materials were stained by ionized calcium binding adapter molecule-1 (Iba-1), a marker for macrophages. The debris was also positive for periodic acid-Schiff (PAS). An enlarging the area of RPE was detected just after the blue LED exposure especially around the optic nerve, and this led to a secondary degeneration of the photoreceptors. Exposure of pigmented mice to 3 consecutive days of blue LED light will cause RPE and photoreceptor damage. The damage led to an accumulation of macrophages and drusen-like materials around the outer segments of the photoreceptors. This blue light exposed model may be useful for investigating the pathogenesis of non-exudative age-related macular degeneration.

read more

14:45

The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance. GreenMedInfo

PMID:  Neuroscience. 2016 Dec 17 ;339:296-307. Epub 2016 Oct 14. PMID: 27751961 Abstract Title:  Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity. Abstract:  To save energy, the European directives from the Eco-design of Energy Using Products (2005/32/CE) have recommended the replacement of incandescent lamps by more economic devices such as Light Emitting Diodes (LEDs). However, the emission spectrum of these devices is enriched in blue radiations, known to be potentially dangerous to the retina. Recent studies showed that light exposure contributes to the onset of early stages of age-related macular degeneration (AMD). Here, we investigate, in albinos and pigmented rats, the effects of different exposure protocols. Twenty-four hours exposure at high luminance was compared to a cyclic (dark/light) exposure at domestic levels for 1week and 1month, using different LEDs (Cold-white, blue and green), as well as fluorocompact bulbs and fluorescent tubes. The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance and not only in extreme experimental conditions, as previously reported. It is important to note that the current regulations and standards have been established on the basis of acute light exposure and do not take into account the effects of repeated exposure.

read more

14:29

Blue light effect on retinal pigment epithelial cells by display devices. GreenMedInfo

PMID:  Integr Biol (Camb). 2017 05 22 ;9(5):436-443. PMID: 28386617 Abstract Title:  Blue light effect on retinal pigment epithelial cells by display devices. Abstract:  Blue light has high photochemical energy and induces cell apoptosis in retinal pigment epithelial cells. Due to its phototoxicity, retinal hazard by blue light stimulation has been well demonstrated using high intensity light sources. However, it has not been studied whether blue light in the displays, emitting low intensity light, such as those used in today's smartphones, monitors, and TVs, also causes apoptosis in retinal pigment epithelial cells. We attempted to examine the blue light effect on human adult retinal epithelial cells using display devices with different blue light wavelength ranges, the peaks of which specifically appear at 449 nm, 458 nm, and 470 nm. When blue light was illuminated on A2E-loaded ARPE-19 cells using these displays, the display with a blue light peak at a shorter wavelength resulted in an increased production of reactive oxygen species (ROS). Moreover, the reduction of cell viability and induction of caspase-3/7 activity were more evident in A2E-loaded ARPE-19 cells after illumination by the display with a blue light peak at a shorter wavelength, especially at 449 nm. Additionally, white light was tested to examine the effect of blue light in a mixed color illumination with red and green lights. Consistent with the results obtained using only blue light, white light illuminated by display devices with a blue light peak at a shorter wavelength also triggered increased cell death and apoptosis compared to that illuminated by display devices with a blue light peak at longer wavelength. These results show that even at the low intensity utilized in the display devices, blue light can induce ROS production and apoptosis in retinal cells. Our results also suggest that the blue light hazard of display devices might be highly reduced if the display devices contain less short wavelength blue light.

read more

14:20

Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions. GreenMedInfo

PMID:  Free Radic Biol Med. 2018 Jul 21 ;126:27-40. Epub 2018 Jul 21. PMID: 30040995 Abstract Title:  Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions. Abstract:  AIMS: The ocular surface is the very first barrier between the visual system and external environment. It protects the eye from the exposure to various light sources that significantly emit in blue spectrum. However, the impact of blue light on the ocular surface has been poorly explored so far. In this study, we investigated in vitro the phototoxicity of blue light illumination in human epithelial cells of the ocular surface. We worked either in basal conditions or under hyperosmolar stress, in order to mimic dry eye disease (DED) that is the most common disease involving the ocular surface.RESULTS: Corneal and conjunctival epithelial cells suffered the most from violet-blue light but also from longer-wave blue light. Exposure to blue wavebands significantly decreased cellular viability, impacted on cellular morphology and provoked reactive oxygen species (ROS) over-production. Conjunctival epithelial cell line had a greater photosensitivity than the corneal epithelial one. Hyperosmolar stress potentiated the blue light phototoxicity, increasing inflammation, altering mitochondrial membrane potential, and triggering the glutathione-based antioxidant system.INNOVATION: In human epithelial corneal and conjunctival cells of the ocular surface, we demonstrated the harmful impact of blue light on viability, redox state and inflammation processes, which was modified by hyperosmolarity.CONCLUSION: Blue light induced cell death and significant ROS production, and altered the expression of inflammatory genes and operation of the cellular defensive system. We established for the first time that hyperosmolar stress impacted phototoxicity, further suggesting that DED patients might be more sensitive to blue light ocular toxicity.

read more

14:15

Use of modified spectacles and light bulbs to block blue light at night may prevent postpartum depression. GreenMedInfo

PMID:  Med Hypotheses. 2009 Aug ;73(2):251-3. Epub 2009 Mar 28. PMID: 19329259 Abstract Title:  Use of modified spectacles and light bulbs to block blue light at night may prevent postpartum depression. Abstract:  In 2001 it was discovered that exposing the eyes to light in the blue end of the visible spectrum suppresses the production of the sleep hormone, melatonin. New mothers need to get up during the night to care for their babies. This is the time when melatonin is normally flowing. Exposing their eyes to light can cut off the flow. It may also reset their circadian (internal) clock. On subsequent nights the melatonin may not begin flowing at the normal time making it difficult to fall asleep. Over time, disruption of the circadian rhythm plus sleep deprivation may result in depression. Women suffering postpartum depression were enrolled in a small clinical trial. Some were provided with glasses and light bulbs that block blue light. Others were equipped with glasses and light bulbs that looked colored but did not block the rays causing melatonin suppression. Those with the"real glasses"recovered somewhat more quickly than those with the placebo glasses and light bulbs. The hypothesis that should be tested in large scale clinical trials is that the risk of postpartum depression can be reduced when a new mother avoids exposing her eyes to blue light when she gets up at night to care for her baby. In the meantime, all new mothers may benefit from using glasses and light bulbs that block blue light when getting up at night to care for their babies.

read more

14:00

The use of blue light smartphones was associated with significantly decreased sleepiness and confusion-bewilderment. GreenMedInfo

PMID:  J Psychiatr Res. 2017 04 ;87:61-70. Epub 2016 Dec 12. PMID: 28017916 Abstract Title:  Effects of smartphone use with and without blue light at night in healthy adults: A randomized, double-blind, cross-over, placebo-controlled comparison. Abstract:  Smartphones deliver light to users through Light Emitting Diode (LED) displays. Blue light is the most potent wavelength for sleep and mood. This study investigated the immediate effects of smartphone blue light LED on humans at night. We investigated changes in serum melatonin levels, cortisol levels, body temperature, and psychiatric measures with a randomized, double-blind, cross-over, placebo-controlled design of two 3-day admissions. Each subject played smartphone games with either conventional LED or suppressed blue light from 7:30 to 10:00PM (150 min). Then, they were readmitted and conducted the same procedure with the other type of smartphone. Serum melatonin levels were measured in 60-min intervals before, during and after use of the smartphones. Serum cortisol levels and body temperature were monitored every 120 min. The Profile of Mood States (POMS), Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), and auditory and visual Continuous Performance Tests (CPTs) were administered. Among the 22 participants who were each admitted twice, use of blue light smartphones was associated with significantly decreased sleepiness(Cohen's d = 0.49, Z = 43.50, p = 0.04) and confusion-bewilderment (Cohen's d = 0.53, Z = 39.00, p = 0.02), and increased commission error (Cohen's d = -0.59, t = -2.64, p = 0.02). Also, users of blue light smartphones experienced a longer time to reach dim light melatonin onset 50% (2.94 vs. 2.70 h) and had increases in body temperature, serum melatonin levels, and cortisol levels, although these changes were not statistically significant. Use of blue light LED smartphones at night may negatively influence sleep and commission errors, while it may not be enough to lead to significant changes in serum melatonin and cortisol levels.

read more

13:49

These results further emphasize the interaction of light exposure with depression. GreenMedInfo

PMID:  Acta Psychiatr Scand. 2018 Mar ;137(3):231-240. Epub 2018 Jan 15. PMID: 29336011 Abstract Title:  Decreased retinal sensitivity in depressive disorder: a controlled study. Abstract:  OBJECTIVE: To compare pupil responses in depressed patients with a seasonal pattern, depressed patients without a seasonal pattern and healthy controls as a function of daylight hours on the testing day.METHOD: Patients suffering from a major depressive episode were included in wintertime. The pupil light reflex was measured at inclusion and in the following summer using a binocular pupillometer. A protocol of low (1 lux) and high (400 lux) intensity red and blue lights was used to assess rod, cone and melanopsin-containing intrinsic photosensitive retinal ganglion cell input to the pupil reflex.RESULTS: The mean group pupil responses associated with a melanopsin-mediated sustained pupil response at 400 lux blue light were significantly reduced in the depressed subjects (N = 39) as compared to the healthy controls (N = 24) (P = 0.023). Across all groups, a reduction in number of daylight hours was significantly associated with a reduction in sustained pupil response (P = 0.007). All groups showed an equal effect of daylight hours on the melanopsin-mediated sustained pupil response.CONCLUSION: The melanopsin-mediated sustained pupil contraction to offset of high-intensity blue light is reduced in depressed patients. These results further emphasize the interaction of light exposure with depression.

read more

13:25

Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats. GreenMedInfo

PMID:  Photochem Photobiol Sci. 2018 Apr 18 ;17(4):386-394. PMID: 29404551 Abstract Title:  Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats. Abstract:  OBJECTIVES: Ambient light has a vital impact on mood and cognitive functions. Blue light has been previously reported to play a salient role in the antidepressant effect via melanopsin. Whether blue light filtered white light (BFW) affects mood and cognitive functions remains unclear. The present study aimed to investigate whether BFW led to depression-like symptoms and cognitive deficits including spatial learning and memory abilities in rats, and whether they were associated with the light-responsive function in retinal explants.METHODS: Male Sprague-Dawley albino rats were randomly divided into 2 groups (n = 10) and treated with a white light-emitting diode (LED) light source and BFW light source, respectively, under a standard 12:12 h L/D condition over 30 days. The sucrose consumption test, forced swim test (FST) and the level of plasma corticosterone (CORT) were employed to evaluate depression-like symptoms in rats. Cognitive functions were assessed by the Morris water maze (MWM) test. A multi-electrode array (MEA)system was utilized to measure electro-retinogram (ERG) responses induced by white or BFW flashes.RESULTS: The effect of BFW over 30 days on depression-like responses in rats was indicated by decreased sucrose consumption in the sucrose consumption test, an increased immobility time in the FST and an elevated level of plasma CORT. BFW led to temporary spatial learning deficits in rats, which was evidenced by prolonged escape latency and swimming distances in the spatial navigation test. However, no changes were observed in the short memory ability of rats treated with BFW. The micro-ERG results showed a delayed implicit time and reduced amplitudes evoked by BFW flashes compared to the white flash group.CONCLUSIONS: BFW induces depression-like symptoms and temporary spatial learning deficits in rats, which might be closely related to the impairment of light-evoked output signals in the retina.

read more

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Thursday, 13 September

20:50

Dr Paul Connett, Dr Vyvyan Howard & Declan Waugh: Fluoride is a neurotoxin that reduces the IQ of children Fluoride Action Network

What is it about New Zealanders that say fluoridation is good for us? Why ignore and dismiss the European Union who ban it and note that it is a significant health issue? How is it that New Zealanders are now agreeable to mass medication of fluoride in their drinking water, whilst 41 nations of Europe collectively ban its use?

With fluoride being a neurotoxin, there is now, in total, around 377,655,000 million people worldwide drinking artificially fluoridated water. This represents 5% of the worlds population.

Yet, there are more people drinking fluoridated water in the United States than the rest of the world combined, with about one third to three quarters of the population now drinking it daily.

Today 50% of NZ tap water is fluoridated, a whopping 73% of Ireland and 10% of England and Spain as well.

Science has known for a hundred years that fluoride suppresses thyroid function. Fetuses can be born without a thyroid gland at all but the mother will provide the hormone. The importance of the mother and what she takes into her body is very relevant. Professor PJ Pop in the Netherlands has a number of papers and what is noticed is that there is reduced intelligence once the fetus is born.

Pregnancy, postpartum and the thyroid: isnt it time to offer women optimal care?

Please listen to understand this crucial information.

Note that students studying water management or to become doctors were never told anything about fluoridation in University. So they pass through University, in a state of unknowingness about what is added to the water.

There is very little fluoride research on the human body

Declan says he first came into the knowingness that something was awry with fluoride in 2006 when he found that no studies or research had been completed on the human body, other than the effect on teeth and bones. No other organs, or brain tissue or anything.

Then in the US the National Academies 2006 report on fluoride and drinking water impelled the top committee who were responsible for this report, to bring together their top academics across the USA, from neurology, toxicology and dentistry to assess this data. They then put together a list of close to 70 different areas that they needed studies to be taken, to fill the gaps of lack of knowledge for the effects of fluoride on peoples health.

Could Downs Syndrome be a result of exposure to drinking Fluoride in tap water?

Declan goes on to say that Ireland has the highest ratio of Downs Syndrome on earth and these academics also posited the question of the possibility that it was ...

Tuesday, 11 September

00:02

AAP: Kids are too Busy Its Time for Doctors to Prescribe Play Natural Society

In a clinical report, the American Academy of Pediatrics urges doctors to write kids a prescription for play, explaining that playtime is vital for childrens social-emotional, cognitive, language, and self-regulation skills.

The report an update to a report released in 2007 notes that ample playtime helps little ones manage stress and forge nurturing relationships with their caretakers.

It reads:

The importance of playtime with children cannot be overemphasized to parents as well as schools and community organizations.

In an accompanying press release, the authors suggest that regular, daily playtime is the conduit to creative, curious, healthier children with 21st-century skills.

One little problem: many kids dont play nearly as often as they should.

According to a 2012 national survey of nearly 9,000 preschool children and parents, only about half of children went outside to walk or play once per day with either parent.

Parents safety concerns or lack of access to parks and other play-friendly environments are likely a few of the obstacles to daily playtime, the AAP says. But children face substantially more academic pressure now than in years past, and fewer schools offer recess and other outlets for fantasy, daydreaming, and creativity. So, even kids who live in a safe area and have plenty of places to play may simply not have the time to.

The report reads:

Many schools have cut recess, physical education, art, and music to focus on preparing children for tests. Unsafe local neighborhoods and playgrounds have led to nature deficit disorder for many children.

In fact, 30% of U.S. kindergarteners no longer have recess. [2]

And heres a not-so-fun fact from the report: from 1981 to 1997, childrens playtime decreased by 25%.

In 2016, a survey funded by the U.K. laundry detergent brand Persil showed that 1 in 3 kids in Britain spent less time outdoors than inmates in maximum security prisons. Yet, study after study points to the importance of connecting with nature, even if its a backyard or some other type of green space.

And lets not downplay the role of technology in keeping kids indoors, disconnected from others and firmly seated on their behinds. Some apps and computer games are excellent when it comes to education, but its an impersonal way of learning about and exploring the world, which is what...

IndyWatch Health Watch Feed Archiver

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

IndyWatch Health Watch Feed was generated at Community Resources IndyWatch.

Resource generated at IndyWatch using aliasfeed and rawdog