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Sunday, 22 October

00:33

Weekend reads: A proposal to end NSF watchdog; Power pose criticism redux; A limit to lifetime word count? Retraction Watch

The week at Retraction Watch featured a journal that will pay authors royalties, a new estimate of how many papers are affected by contaminated cell lines, and threats by more than 20 researchers at Johns Hopkins to resign from a journals editorial board if a paper isnt retracted. Heres what was happening elsewhere: Sen. Rand []

The post Weekend reads: A proposal to end NSF watchdog; Power pose criticism redux; A limit to lifetime word count? appeared first on Retraction Watch.

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Saturday, 21 October

22:43

200 Hours in Emergency Room For Family of Autistic Boy AGE OF AUTISM

Note: Tots become teens. Tweens become twentysomethings. What will happen when the tsunami of children with autism hits puberty and adulthood and their behaviors need support that frankly doesn't exist in our medical world? We closed our institutions decades ago...

21:03

An Anarchist Teaches Patients to Make Their Own Meds Mad In America

From STAT: In response to rising drug costs, anarchist and biohacker Michael Laufer plans to teach people to manufacture their own medications.

Health professionals have strenuously warned against DIY pharmaceuticals, but Laufer sees his work as a moral crusade against the patent laws and market forces that let drug companies price vital remedies out of reach for many patients.

To deny someone access to a lifesaving medication is murder, he said. And an act of theft [of intellectual property] to prevent an act of murder is morally acceptable.'

Article

21:02

Birthday Letter: Sylvia Plath and Daddy Mad In America

In this piece for The Paris Review, Belinda McKeon analyzes the poetry and letters Sylvia Plath wrote in the few months just before her suicide.

21:01

Why More American Teens Than Ever Suffer From Severe Anxiety Mad In America

In this piece for The New York Times, Benoit Denizet-Lewis explores the social, cultural, and economic factors that have contributed to the significant rise in severe anxiety among American teenagers over the past several years. He also explores the challenges faced by parents of anxious teenagers, such as the question of whether to push their children to face their fears or protecting them from anxiety-producing circumstances.

21:01

David Mielke: Educating in the era of the psychiatric diagnosis Mad In America

This week we on the Mad in America podcast we interview David Mielke. David is a psychology graduate and teacher in a California high school who has become increasingly concerned about the number of children that he teaches that have a psychiatric diagnosis and are on psychiatric drugs.

In this interview, we discuss Davids experiences as an educator and how teachers can empower students to have more confidence in themselves.

In the episode we discuss:

  • How David studied psychology and then came to be a teacher at Culver City High School in California.
  • How an experience witnessing electroshock therapy made an indelible mark on his approach to educating.
  • How David knew from interacting with his students that most often their struggles were because of difficult circumstances, such as issues at home, rather than brain diseases in need of diagnosis.
  • How David has observed that many of his students have internalised their diagnostic labels.
  • The relationship between a psychiatric diagnosis and learned helplessness.
  • The tensions that may arise between school policies and guidance, teachers and parents when a psychiatric diagnosis is involved.
  • The power inherent in psychotherapy to connect with and support people in difficulty.

Relevant links:

Davids interview on the Peter Breggin hour

Skinner Operant Conditioning

Irving Kirsch on 60 minutes (video)

Researchers Confirm That Relative Age Impacts ADHD Diagnosis

To get in touch with us email: podcasts@madinamerica.com

Mad in America 2017

16:00

Automatic Brain: The Magic of the Unconscious Mind Articles

By Dr. Mercola

Automatic Brain: The Magic of the Unconscious Mind is a fascinating first segment of a two-part documentary about the brain. The 52-minute film is based on the belief that your subconscious mind manages about 90 percent of everything you do whether you are asleep or awake. Through a series of interviews and entertaining demonstrations, neuroscientists and magicians team up to explain and vividly demonstrate the relationship between your conscious and unconscious brain.

You may be surprised to discover your conscious mind plays only a minor role in guiding your life. In fact, most of what you think, say and do every day is a function of your automatic, or unconscious brain (also known as your subconscious). As such, much of the time, your brain is running your life on autopilot.

For example, think about brushing your teeth or even driving, and how often you perform those and other routine tasks without being fully conscious of them. The movie is seasoned with plenty of sleight of hand tricks and visual experiments designed to both educate and entertain you. If you have children at home, you might want to share some of the trick segments with them. Watching with others or alone, I think you will benefit from taking a closer look at the inner workings of your brain.

What Do Scientists Know About the Unconscious Mind?

Given that your brain weighs just 3 pounds and has been the subject of countless scientific studies, you might think weve already learned all we can about it. To the contrary, the brain is remarkably complex and we have much, much more to discover. This film suggests your unconscious mind drives most of your daily routines and habits.

The brain decides things before we can consciously think about it, says Allan Snyder, D.Sc., director of the University of Sydneys Center for the Mind. Decisions are almost dictated to us. For starters, consider how your brain can handle this mixed-up sentence: Wyh sohuld yuo wacth tihs flim atbou yoru barin?

Without much effort or conscious thought, your brain fills in the gaps of perception, enabling you to understand the question to be: Why should you watch this film about your brain? Psychology professor John Bargh, Ph.D., founder of the automaticity in cognition, motivation and evaluation laboratory at Yale University, suggests the unconscious mind is asserting itself more and more as researchers continue to study the human brain. He states:

Unconscious influences are everywhere, and as research progresses, it's never going the other way. Were not saying oh, we used to think these things were all unconscious, but now we find out they're conscious. It's exactly the opposite....

Does Sickness Smell? Articles

By Dr. Mercola

Your olfactory sense, or the ability to smell, is integral to your health. Inside your nasal passages are two patches of cells designed to detect odors. They are made up of nearly 6 million olfactory receptor cells that allow you to detect and differentiate thousands of different scents. Although impressive, other animals have an even more acute sense of smell as often their survival is dependent on being able to smell enemies or their food.1

Your sense of smell is also intimately tied to your emotions, memories, ability to taste and even to sexual attraction. Research demonstrates that your ability to smell may peak at age 8. According to different studies, you may begin to lose sensitivity to scent between age 15 and your early 20s.2 However, that loss in sensitivity to scent is not consistent from person to person as some 80-year-olds have a sense of smell as keen as that of a young adult.

Some degradation of your sense of smell, and therefore your ability to taste food, may be related to air pollution.3 A combination of solvents, pesticides, disinfectants, pharmaceuticals and perfumes may have a negative effect over the years on your ability to discern scent and on your sensitivity to smell.4 Loss of this ability may affect your capacity to pull up memories from the past.

Research shows odors are an effective reminder of experience,5 which may be tied to the way your brain processes odors and memories. Researchers have also found your sense of smell may predict your longevity, and you may be able to smell the scent of illness. In other words, the relationship between your sense of smell and your health is a two-way street.

Illness Has a Smell

From the early days of medical practice, doctors have used smell and taste to determine if their patients had a disease. Examples may be found from the late 1600s when English physician Thomas Willis observed the relationship between sweet-tasting urine and diabetes,6 to physicians today who may note a fruity scent on the breath of a diabetic whose blood sugar is too high.7 Over the years physicians have moved away from...

09:59

Astragaloside exerts its protective effect against sepsis-induced acute lung injury in rats. GreenMedInfo

PMID:  Saudi Pharm J. 2016 May ;24(3):341-7. Epub 2016 May 4. PMID: 27275126 Abstract Title:  Protective effect of Astragaloside IV against sepsis-induced acute lung injury in rats. Abstract:  The study aimed to explore the protective effects of AS-IV against sepsis-induced ALI. Sepsis was induced by cecal ligation and puncture (CLP) method in Sprague Dawley rats. Rats were randomly assigned into five groups: animals undergoing a sham CLP (sham group); animals undergoing CLP (CLP group); animals undergoing CLP and treated with AS-IV at 2.5 mg/kg bw (low-dose AS-IV [L-AS] group), at 5 mg/kg bw (mid-dose AS-IV [M-AS] group), and at 10 mg/kg bw (high-dose AS-IV [H-AS] group). At 6 h, 12 h and 24 h post-CLP surgery, six rats were respectively sacrificed to collect blood and lung tissue samples. The levels of arterial blood gas index, lung water content, protein level and leukocyte counts (total amount, neutrophils and lymphocytes) in bronchoalveolar lavage fluid (BALF) and cytokines such as TNF- and IL-6 in BALF were measured at each time point in different groups. HE-staining and optical microscopy were performed to examine the pathological changes in lungs. The 72 h-survival rate of each group was also recorded. PaO2 was decreased significantly, while the lung water content, BALF protein level, cell numbers, BALF cytokine TNF- and IL-6 levels were increased significantly for CLP group as compared with sham group. Moreover, pathological injury was observed in lung tissue indicating the successful sepsis-induced ALI model. Speaking of the effect of AS-IV, we founded that, compared with the CLP group, the AS-IV treatment groups could significantly alleviate all the above negative changes exited in the CLPgroup in a dose-dependent manner. What's more, the pathological injury was also gradually improved by AS-IV treatment compared with the CLP rats. AS-IV exerts its protective effect against sepsis-induced ALI in rats via improving pulmonary ventilation function, decreasing the permeability of alveolar epithelium and capillary as well as repressing lung inflammation.

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09:43

Astragaloside could efficiently improve lipid metabolism in obese mice. GreenMedInfo

PMID:  Sci Rep. 2016 Jul 22 ;6:30190. Epub 2016 Jul 22. PMID: 27444146 Abstract Title:  Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network. Abstract:  Obesity is a worldwide threat to public health in modern society, which may result from leptin resistance and disorder of thermogenesis. The present study investigated whether astragaloside IV (ASI) could prevent obesity in high-fat diet (HFD)-fed and db/db mice. In HFD-fed mice, ASI prevented body weight gain, lowered serum triglyceride and total cholesterol levels, mitigated liver lipid accumulation, reduced fat tissues and decreased the enlargement of adipose cells. In metabolic chambers, ASI lessened appetite of the mice, decreased their respiratory exchange ratio and elevated VCO2 and VO2 without altering circadian motor activity. Moreover, ASI modulated thermogenesis associated gene expressions in liver and brawn fat tissues, as well as leptin resistance evidenced by altered expressions of leptin, leptin receptor (ObR) or appetite associated genes. In SH-SY5Y cells, ASI enhanced leptin signaling transduction. However, in db/db mice, ASI did not change body weight gain and appetite associated genes. But it decreased serum triglyceride and total cholesterol levels as well as liver triglyceride. Meanwhile, it significantly modulated gene expressions of PPAR, PGC1-, UCP2, ACC, SCD1, LPL, AP2, CD36 and SREBP-1c. Collectively, our study suggested that ASI could efficiently improve lipid metabolism in obese mice probably through enhancing leptin sensitivity and modulating thermogenic network.

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09:38

Astragaloside IV mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. GreenMedInfo

PMID:  Inflammation. 2016 Oct ;39(5):1835-41. PMID: 27525425 Abstract Title:  Inhibitory Effects of Astragaloside IV on Bleomycin-Induced Pulmonary Fibrosis in Rats Via Attenuation of Oxidative Stress and Inflammation. Abstract:  In this study, we investigated the effects of astragaloside IV (As-IV) on pulmonary fibrosis and its mechanisms of action. Sprague-Dawley rats were used in a model of pulmonary fibrosis induced by an intratracheal instillation of bleomycin (BLM). Rats were intraperitoneally injected with As-IV (10, 20, 50 mg/kg) daily for 28 days, while the rats in control and BLM groups were injected with a saline solution. The effects of As-IV treatment on pulmonary injury were evaluated with the lung wet/dry weight ratios, cell counts, and histopathologic. Oxidative stress was evaluated by detecting the levelsof malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and reactive oxygen species (ROS) in lung tissue. Inflammation was assessed by measuring the levels of tumor necrosis factor (TNF)-, interleukin (IL)-1, and IL-6 in bronchoalveolar lavage fluid (BALF). Theresults indicated that As-IV treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced oxidative stress and inflammation. Our findings indicate that As-IV-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. Its mechanisms of action are associated with inhibiting oxidative stress and inflammatory response. In summary, our study suggests a therapeutic potential of As-IV in the treatment of pulmonary fibrosis.

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09:34

Nanochips And Smart Dust Dangerous New Face Of Human Microchipping Agenda Natural Blaze

By Makia Freeman

Nanochips and Smart Dust are the new technological means for the advancement of the human microchipping agenda. Due to their incredibly tiny size, both nanochips and Smart dust have the capacity to infiltrate the human body, become lodged within, and begin to set up a synthetic network on the inside which can be remotely controlled from the outside. Needless to say, this has grave freedom, privacy and health implications, because it means the New World Order would be moving from controlling the outside world (environment/society) to controlling the inside world (your body). This article explores what the advent of nanochips and Smart dust could mean for you.

Different Forms of Control

Humanitys history is filled with examples of societies where the people were sharply divided into 2 categories: rulers and slaves. In the distant past, the slaves have usually been kept in place because the rulers had access to and control over the resources, such as money, food, water, weapons or other necessities of life (control of the environment).

In our more recent history, control was implemented not only by monopolizing resources but also via propaganda (control of the mind). This has manifested itself in many ways, e.g. the caste system in India (you must remain in your position on the hierarchical ladder for life), the royal bloodlines in Rome, the Middle East and Europe (who claimed an inherent and divine right to rule), the centralization of power in Nazi Germany and Soviet Russia during the 1930s (where a single autocrat or a small committee decided the fate of millions), and finally in the West (especially in the US) with the advent of specialized PR and mind co...

09:30

Astragaloside IV alleviates E. coli-caused peritonitis. GreenMedInfo

PMID:  Int Immunopharmacol. 2016 Oct ;39:377-382. Epub 2016 Aug 17. PMID: 27543854 Abstract Title:  Astragaloside IV alleviates E. coli-caused peritonitis via upregulation of neutrophil influx to the site of infection. Abstract:  Astragaloside IV (AS-IV), an active saponin purified from Astragali Radix, has been identified with broad biological and pharmacological activities. In the present study, we continue to explore the potential effect of AS-IV on antibacterial response using an acute E. coli peritoneal infection model. Our findings implied that administration of AS-IV decreases mortality in mice challenged by lethal E. coli infection. The protection of AS-IV was related to promotion of neutrophil extravasation into the peritoneum and bacterial clearance. Toll-like receptor (TLR) activation in neutrophils has been reported to reduce CXCR2 expression and subsequent neutrophil migration. Our data indicated that AS-IV prevented the reduction of CXCR2 expression and neutrophil migration induced by LPS, the activator for TLR4. Moreover, we found that AS-IV blocks LPS-induced suppression of CXCR2 on neutrophils by inhibiting the expression of G protein-coupled receptor kinase-2 (GRK2), an agonist that regulates desensitization and internalization of chemokine receptors. Taken together, these data propose that AS-IV, through modulating GRK2-CXCR2 signal in neutrophils, offers an essential efficacy on host antibacterial immunity.

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09:23

Astragaloside IV has a therapeutic effect on inflammation promoted by high-mobility group box 1 protein. GreenMedInfo

PMID:  Pharm Biol. 2016 Dec ;54(12):3217-3225. Epub 2016 Aug 26. PMID: 27564970 Abstract Title:  Astragaloside IV attenuates inflammatory reaction via activating immune function of regulatory T-cells inhibited by HMGB1 in mice. Abstract:  CONTEXT: High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory. Some experiments have demonstrated a vital role for HMGB1 to modulate the immune function of regulatory T-cells (Tregs). Astragaloside IV (AST IV), an extract from Astragalus membranaceus Moench (Leguminosae), has been shown to exert potent cardioprotective and anti-inflammatory effects. It is still unclear whether AST IV has a latent effect on the proinflammatory ability of HMGB1 with subsequent activation of Tregs in vivo.OBJECTIVE: This research explores the antagonism of different doses of AST IV on the immunologic function of Tregs mediated by HMGB1.MATERIALS AND METHODS: Mouse models (BALB/c) were constructed by which normal saline or AST IV was administered i.p. at 2, 4 and 6 days after the administration i.p. of 20g recombinate HMGB1. Spleen was used to procure Treg and CD4(+)CD25(-) T-cells which were co-cultured with Treg. Cell phenotypes of Tregs(Foxp3) were examined, and the cytokine levels in supernatants and the proliferation of T-cells were assayed. Gene expression was measured by RT-PCR.RESULTS: (1) The expression levels of Foxp3 in Treg on post-stimulus days (PSD) 1-7 were significantly decreased in the HMGB1 group in comparison to those in the control group mice (p

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09:19

Research review on the pharmacological effects of astragaloside IV. GreenMedInfo

PMID:  Fundam Clin Pharmacol. 2017 Feb ;31(1):17-36. Epub 2016 Sep 23. PMID: 27567103 Abstract Title:  Research review on the pharmacological effects of astragaloside IV. Abstract:  Astragalus membranaceus Bunge has been used to treat numerous diseases for thousands of years. As the main active substance of Astragalus membranaceus Bunge, astragaloside IV (AS-IV) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic nephropathy. Based on studies published during the past several decades, the current state of AS-IV research and the pharmacological effects are detailed, elucidated, and summarized. This review systematically summarizes the pharmacological effects, metabolism mechanism, and the toxicity of AS-IV. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, AS-IV possesses potential for broad application in many diseases.

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09:06

These findings showed astragaloside IV to be beneficial to type 2 diabetic nephropathy. GreenMedInfo

PMID:  Sci Rep. 2016 Sep 2 ;6:32545. Epub 2016 Sep 2. PMID: 27585918 Abstract Title:  Astragaloside IV ameliorates renal injury in db/db mice. Abstract:  Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IVon renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFB and Erk1/2 signaling pathways.

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08:43

AS IV is able to protect developing brain from anesthesia-induced neuroapoptosis GreenMedInfo

PMID:  Exp Ther Med. 2016 Sep ;12(3):1829-1835. Epub 2016 Jul 13. PMID: 27588101 Abstract Title:  Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain. Abstract:  Exposure to general anesthesia may cause severe neurotoxicity in developing brain due to neuronal apoptosis. Astragaloside IV (AS IV) has antioxidant and antiapoptosis properties; however, its effects on anesthesia-induced neuroapoptosis have not been studied. In the present study, we determined whether AS IV pre-treatment is able to reduce isoflurane exposure-induced neuroapoptosis in rats. New born rats were pre-treated with AS IV or solvent by oral gavage for three days, then exposed to isoflurane. The results showed that pre-treatment of AS IV significantly inhibited isoflurane-induced neural apoptosis in the hippocampus of new born rats, and such protection was accompanied by reduced levels of caspase-3, nuclear factor-B activation and phosphorylated c-Jun N-terminal kinase, extracellular signal-regulated kinase and increased levels of B-cell lymphoma-2, glycogen synthase kinase-3, Klotho and phosphorylated protein kinase B. Furthermore, AS IV pre-treatment significantly alleviated isoflurane-induced oxidativestress and proinflammatory cytokine release in the rat hippocampus and serum. In summery, the results of the study demonstrated that AS IV is able to protect developing brain from anesthesia-induced neuroapoptosis via anti-oxidant and anti-inflammatory activities.

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08:39

Astragaloside IV ameliorates necrotizing enterocolitis. GreenMedInfo

PMID:  Exp Ther Med. 2016 Oct ;12(4):2702-2708. Epub 2016 Aug 30. PMID: 27698775 Abstract Title:  Astragaloside IV ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin D3-upregulated protein 1/NF-B signaling pathway. Abstract:  Astragaloside IV (AS-IV) is a flavonoid from the plant Astragalus membranaceus (Fisch) Bge that has a wide range of therapeutic effects. The aim of the present study was to examine the effect of AS-IV on rats with necrotizing enterocolitis (NEC) under oxidative stress and inflammation. Newborn Sprague-Dawley rats were induced with NEC by asphyxia and hypothermia applied on 3 consecutive days. The rats were orally administered AS-IV at 25, 50 and 75 mg/kg for 4 days. The results revealed that AS-IV administration prevented NEC-induced decrease in the concentration of malondialdehyde and myeloperoxidase, and increase in the activity of glutathione (GSH) and superoxide dismutase in murine models. AS-IV also inhibited NEC-induced elevation in the levels of interleukin (IL)-6, IL-1, tumor necrosis factor- and nuclear factor (NF)-B. The effects of AS-IV were achieved under inflammation and oxidative stress. Western blotting demonstrated that AS-IV substantially inhibited the phosphorylated (p)-IB, NF-Bp65, p-NF-Bp65 protein levels and increased vitamin D3 upregulated protein 1 (VDUP1) and IB protein levels. These data indicate that AS-IV may be effective in the protection of NEC-induced ileum degeneration by inhibiting the levels of inflammatory markers and oxidative stress via the regulation of the VDUP1/NF-B signaling pathway.

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08:29

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage. GreenMedInfo

PMID:  Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID: 27816726 Abstract Title:  Astragaloside IV protects rat gastric mucosa against aspirin-induced damage. Abstract:  Aspirin (Asp) is commonly used as an anti-inflammatory drug, but the long-term usage of Asp can lead to severe gastrointestinal damage. Thus the co-administering of Asp with another drug that can suppress its side effect while having no impact on its anti-inflammatory activity would be ideal. Astragaloside IV (AST-IV) is a natural anti-inflammatory compound that has been shown to protect rat gastric mucosa from anhydrous ethanol-inflicted damage. In this study, we investigated whether AST-IV could protect rat gastric mucosa against Asp-induced gastric mucosal damage. Wistar rats administered 150mg/kg Asp showed significant damage to the gastric mucosa, as revealed by gastric damage score and histological evaluation. However, this was largely abolished by co-administering Asp and 25mg/kg or 50mg/kg AST-IV. The protective mechanism of AST-IV involved the suppression of Asp-induced inhibition of cycloxygenase-1 (COX-1) expression, prostaglandin E2 (PGE2) production, superoxide dismutase (SOD) activity and nitric oxide (NO) production. AST-IV blocked Asp-induced inhibition of SOD activity through preventing Asp from inhibiting the expression of SOD-1, both at the mRNA and protein levels. AST-IV did not appear to interfere with the anti-inflammatory activity of Asp since COX-2 level in model gastritis rats treated with Asp plus AST-IV was equally suppressed as in model gastritis rats treated with Asp alone. The results clearly showed that AST-IV could neutralize the toxicity of Asp while having no impact on its anti-inflammatory activity. AST-IV could therefore be considered as a potential drug for relieving the side effect associated with the long-term usage of Asp.

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08:23

These results demonstrate that Astragaloside IV protects against the progression of renal fibrosis. GreenMedInfo

PMID:  Int Immunopharmacol. 2017 Jan ;42:18-24. Epub 2016 Nov 14. PMID: 27855303 Abstract Title:  Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-B in vivo and in vitro. Abstract:  Renal fibrosis is characterized by infiltration of inflammatory cells, activation and proliferation of fibroblasts, and accumulation of extracellular matrix (ECM). Astragalus membranaceus (AM) is traditional Chinese medicine and has a range of pharmacological effects. Astragaloside IV (As IV) is the main compound of AM and has anti-inflammation activities. Whether As IV ameliorates renal interstitial fibrosis by inhibiting inflammation remains unknown. Accordingly, this study investigated the ameliorating effect of As IV on renal fibrosis. Renal fibrosis was induced in vivo using the unilateral ureteral obstruction (UUO) model. UUO mice were administered intragastrically with As IV (20 and 40mg/kg/day). After a week, ECM including fibronectin and collagen I was examined by Immunohistochemistry and Western blot, inflammatory cells (CD68 and CD3) were detected by Immunohistochemistry, the release of inflammatory cytokines (tumor necrosis factor- and interleukin-1) was inspected by polymerase chain reaction, and signaling pathway was determined by Western blot. In vitro, 100ng/ml lipopolysaccharide (LPS) stimulated epithelial cells to construct the inflammatory model; these cells were treated by As IV (10 and 20M) with or without TAK-242 (1M) for 48h. The released inflammatory cytokines were assayed by enzyme-linked immunosorbent assay, and signaling pathway was evaluated by Western blot. As IV decreased accumulation of ECM and infiltration of inflammatory cells in UUO-induced renal fibrosis. Furthermore, As IV markedly attenuated pro-inflammatory cytokines in UUO mouse and LPS-induced epithelial cells. As IV also inhibited the TLR4 and nuclear factor (NF)-B signaling pathway in vivo and vitro. These results demonstrate that As IV protects against the progression of renal fibrosis by inhibiting inflammation via the TLR4/NF-B signaling pathway.

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08:10

Astragaloside IV enhances cardioprotection of remote ischemic conditioning after acute myocardial infarction. GreenMedInfo

PMID:  Am J Transl Res. 2016 ;8(11):4657-4669. Epub 2016 Nov 15. PMID: 27904669 Abstract Title:  Astragaloside IV enhances cardioprotection of remote ischemic conditioning after acute myocardial infarction in rats. Abstract:  BACKGROUND: Remote ischemic conditioning (RIC) has been shown to be a practical method for protecting the heart from ischemic/reperfusion (I/R) injury. In the present study, we investigated whether or not the combination of RIC and Astragaloside IV (AS-IV) could improve cardioprotection against acute myocardial infarction (AMI)-induced heart failure (HF) when compared with individual treatments.MATERIAL AND METHODS: A rat model of AMI was established via permanent ligation of the left anterior descending coronary artery (LAD). Postoperatively, the rats were randomly grouped into a sham group (n=10), a model group (n=15), an AS-IV alone group (n=15), an RIC alone group (n=15) and a combined treatment group (AS-IV+RIC; n=15). All treatments were administered for 2 weeks.RESULTS: After treatment for 2 weeks, the survival rate was improved, the cardiac function was preserved and the infarcted size was limited in AS-IV alone and RIC alone treatment groups compared to the model group, whereas the combined treatment yielded the most optimal protective effects. Additional studies suggested that AS-IV enhanced the cardioprotective effects of RIC by alleviating myocardial fibrosis, suppressing inflammation, attenuating apoptosis and ameliorating impairment of the myocardial ultrastructural.CONCLUSION: AS-IV enhances the cardioprotective effects of RIC against AMI-induced HF and ventricular remodeling, which represents a potential therapeutic approach for preserving cardiac function and improving the prognosis of AMI.

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07:57

Astragaloside IV ameliorates allergic inflammation by inhibiting key initiating factors in the initial stage of sensitization. GreenMedInfo

PMID:  Sci Rep. 2016 Dec 5 ;6:38241. Epub 2016 Dec 5. PMID: 27917896 Abstract Title:  Astragaloside IV ameliorates allergic inflammation by inhibiting key initiating factors in the initial stage of sensitization. Abstract:  To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model of allergic contact dermatitis (ACD). AS-IV administered in the sensitization phase, rather than in the elicitation phase, dramatically alleviated the symptoms of allergic inflammation. We hypothesized that AS-IV exerts its anti-allergy effects by regulating the production of key pro-allergic cytokines based on the fact that interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) levels increase significantly in the initial stage of the sensitization phase. AS-IV administered in the initial stage of ACD inhibited TSLP and IL-33 expression and reduced the proportion of type-2 innate lymphoid cells (ILC2s). An in vitro study showed that the production of pro-allergic cytokines was significantly inhibited in AS-IV presenting HaCaT cells. We also verified that AS-IV administered only in the initial stage markedly alleviated inflammation, including ear swelling, Th2 cytokine expression, and histological changes. Taken together, these results suggest that AS-IV effectively ameliorates the progression of allergic inflammation by inhibiting key initiating factors, including TSLP and IL-33, and can be used to prevent and/or treat patients with ACD. Our data also suggest that these key pro-allergic cytokines are potential therapeutic targets for allergic diseases.

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07:56

4 Hearty, Meat-Free Casserole Recipes That Will Keep You Warm and Cozy Healthy Holistic Living

This fantastic article was written by Sarah Biren, a baker, cook, author, and blogger living in Toronto. We encourage you to check out her website here! As the days becomes shorter and colder, we tend to crave rich, hearty foods to soothe the gloominess of the season. Its a lot...

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The post 4 Hearty, Meat-Free Casserole Recipes That Will Keep You Warm and Cozy appeared first on Healthy Holistic Living.

07:48

Astragaloside IV inhibits breast cancer cell invasion. GreenMedInfo

PMID:  Int Immunopharmacol. 2017 Jan ;42:195-202. Epub 2016 Dec 5. PMID: 27930970 Abstract Title:  Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling. Abstract:  BACKGROUND: Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain cancers; however, its role in breast cancer remains unclear. The present study investigated the effects of AS-IV on breast cancer in vitro and in vivo and examined the underlying mechanisms.METHODS: The effects of AS-IV on MDA-MB-231 cell proliferation, migration, invasion and metastasis were investigated by MTT and Transwell assays, and western blotting. In addition, an orthotopic mouse tumor model was established for in vivo experiments.RESULTS: AS-IV inhibited the viability and invasive potential of MDA-MB-231 breast cancer cells, suppressed the activation of the mitogen activated protein kinase (MAPK) family members ERK1/2 and JNK, and downregulated matrix metalloproteases (MMP)-2 and -9. The effects of AS-IV were mediated by the downregulation of Vav3, a guanine nucleotide exchange factor, leading to decreased levels of activated Rac1, a Rho family GTPase. Vav3 overexpression promoted cell proliferation and invasion in vitro, whereas Vav3 silencing had the opposite effects. AS-IV suppressed orthotopic breast tumor growth and metastasis to the lungs, whereas ectopic expression of Vav3 reversed the inhibitory effect of AS-IV on cell viability, invasiveness, MAPK signaling and MMP expression.CONCLUSION: The present results provide a mechanistic explanation for the antitumor effects of AS-IV and suggest its potential in the treatment of metastatic breast cancer.

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07:45

Organic Eggs: Exposing the Fraud of Grocery Store Eggs Healthy Holistic Living

This article is shared with permission from our friends at Dr. Mercola. When raised the way nature intended, both chickens and their eggs are healthy sources of high-quality nutrients that many are deficient in especially high-quality protein and healthy fat. Eggs contain complete proteins, meaning they provide the eight...

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07:34

High-dose astragaloside IV has a significant protective effect against D-GalN/LPS-induced acute liver injury. GreenMedInfo

PMID:  Zhonghua Gan Zang Bing Za Zhi. 2016 Oct 20 ;24(10):772-777. PMID: 27938564 Abstract Title:  [Protective effect of astragaloside IV against acute liver failure in experimental mice]. Abstract:  Objective: To investigate the clinical effect of astragaloside IV in the early treatment of mice with acute liver failure and possible mechanisms. Methods: A mouse model of acute liver failure induced by D-galactosamine/lipopolysaccharide (D-GalN/LPS) was established, and the mice were given astragaloside IV at different doses. The survival rate of mice, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, liver histopathological changes, apoptosis of hepatocytes, and the expression of superoxide dismutase (SOD) and malondialdehyde (MDA) were measured in each group. The least significant difference test was used for data with homogeneity of variances, the Dunnett's T3 test was used for data with heterogeneity of variance, and the Kaplan-Meier method was used for survival analysis. Results: Compared with the model group, the high-dose astragaloside IV group had a significant increase in the 48-hour survival rate [60% (9/15) vs 13.3% (2/15), P

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07:29

14 Natural Headache Remedies for Instant Relief Healthy Holistic Living

This article is shared with permission from our friends at Dr. Axe.  Discover triggers and healthy solutions to reduce headache pain Life can get busy and stressful, and the common headache is sometimes overlooked or masked with a painkiller such as aspirin which, especially when overused, can sometimes cause more serious health issues....

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The post 14 Natural Headache Remedies for Instant Relief appeared first on Healthy Holistic Living.

07:26

Beets Boost Brain Health, Prevent Heart Disease And Much More Healthy Holistic Living

This article is shared with permission from our friends at Dr. Mercola. Theres a lot to be said for the humble beet, an easy-to-grow garden vegetable. Whether juiced raw, cooked, pickled or fermented, beets have a wide range of health benefits. The nutrients they contain fight inflammation, lower blood pressure and...

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The post Beets Boost Brain Health, Prevent Heart Disease And Much More appeared first on Healthy Holistic Living.

07:25

Statin Side-Effects: 5 Reasons Why You Probably Shouldnt Take Statins Healthy Holistic Living

This article is shared with permission from our friends at Dr. Mercola. Statin cholesterol-lowering drugs are widely touted as the best way to lower your cholesterol and thereby prevent a heart attack. Theyre recommended to people who have high cholesterol, those who have heart disease, and even for some healthy...

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The post Statin Side-Effects: 5 Reasons Why You Probably Shouldnt Take Statins appeared first on Healthy Holistic Living.

07:20

5 Year Old Is Going Through Menopause This Is Her Rare Condition Healthy Holistic Living

Every woman dreads menopause and the difficult symptoms that it brings. But many of us know that we have a good 40 years after puberty in order to prepare for it. One little girl has not been so lucky. Her childhood has been fast-tracked by a rare disorder that has caused...

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The post 5 Year Old Is Going Through Menopause This Is Her Rare Condition appeared first on Healthy Holistic Living.

07:11

These results demonstrate that astragaloside IV enhances chemosensitivity to cisplatin. GreenMedInfo

PMID:  Cell Physiol Biochem. 2016 ;40(5):1221-1229. Epub 2016 Dec 14. PMID: 27960166 Abstract Title:  Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3. Abstract:  BACKGROUND: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus, has been reported to exhibit anti-inflammation, anti-cancer and immunoregulatory properties. In the present study, we investigated the role of astragaloside IV in the chemoresistance to cisplatin in NSCLC cells.METHODS: We established astragaloside IV-suppressed NSCLC cell lines including A549, HCC827, and NCI-H1299 and evaluated their sensitivity to cisplatin in vitro. In addition, we examined the mRNA and protein levels of B7-H3 in response to cisplatin-based chemotherapy.RESULTS: We showed that high doses of astragaloside IV (10, 20, 40 ng/ml) inhibited NSCLC cell growth, whereas low concentrations of astragaloside IV (1, 2.5, 5 ng/ml) had no obvious cytotoxicity on cell viability. Moreover, combined treatment with astragaloside IV significantly increased chemosensitivity to cisplatin in NSCLC cells. On the molecular level, astragaloside IV co-treatment significantly inhibited the mRNA and protein levels of B7-H3 in the presence of cisplatin. In addition, ectopic expression of B7-H3 diminished the sensitization role of astragaloside IV in cellular responses to cisplatin in NSCLC cells.CONCLUSION: These results demonstrate that astragaloside IV enhances chemosensitivity to cisplatin via inhibition of B7-H3 and that treatment with astragaloside IV and inhibition of B7-H3 serve as potential therapeutic approach for lung cancer patients.

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06:57

Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice. GreenMedInfo

PMID:  Neurosci Lett. 2017 Feb 3 ;639:114-119. Epub 2016 Dec 21. PMID: 28011393 Abstract Title:  Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Abstract:  Astragaloside IV (AS-IV) is the main active component isolated from the traditional Chinese medicinal herb Astragalus membranaceus. Studies have demonstrated that AS-IV has neuroprotective effects in cerebral ischemic models. In this study, we aimed to investigate the effects of AS-IV on memory impairment induced by transient cerebral ischemia and reperfusion in mice, as well as the associated signaling mechanisms. Severe memory deficits were induced by bilateral common carotid artery occlusion (BCCAO) in mice as indicated in the Morris water maze test in this study. Oral administration of AS-IV (10 and 20mg/kg, once per day, started 7days before surgery and continued for 7days after surgery) significantly attenuated memory impairment and neuroinflammation. Moreover, AS-IV treatment significantly reduced the expression of toll-like receptor-4 (TLR4) and its downstream adaptor proteins, including myeloid differentiation primary response gene 88 (MyD88), toll/interleukin-1 receptor-domain containing adaptor-inducing interferon- (TRIF) and tumour necrosis factor receptor associated factor-6 (TRAF6), and subsequently inhibited NF-B phosphorylation. It is well-known that cerebral ischemia and reperfusion injury enhances the formation of reactive oxygen species (ROS) and further neuroinflammation. Importantly, we found that AS-IV suppressed NLRP3 inflammasome activation by controlling ROS production. In addition, AS-IV markedly reduced overactivation of microglia and the overexpression of inflammatory cytokines in the hippocampus compared with the transient cerebral ischemia and reperfusion group. These results suggest that AS-IV might possess neuroprotective effects against transient cerebral ischemia and reperfusion partly through its anti-inflammatory effects by inhibiting TLR4 signaling pathway and NLRP3 inflammasome overactivation.

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06:52

Astragaloside IV attenuates podocyte apoptosis mediated by endoplasmic reticulum stress in diabetic nephropathy. GreenMedInfo

PMID:  Front Pharmacol. 2016 ;7:500. Epub 2016 Dec 21. PMID: 28066247 Abstract Title:  Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca(2+)-ATPase 2 Expression in Diabetic Nephropathy. Abstract:  Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) plays a central role in the pathogenesis of diabetes. This protein has been recognized as a potential target for diabetic therapy. In this study, we identified astragaloside IV (AS-IV) as a potent modulator of SERCA inhibiting renal injury in diabetic status. Increasing doses of AS-IV (2, 6, and 18 mg kg(-1) day(-1)) were administered intragastrically to db/db mice for 8 weeks. Biochemical and histopathological approaches were conducted to evaluate the therapeutic effects of AS-IV. Cultured mouse podocytes were used to further explore the underlying mechanism in vitro. AS-IV dose-dependently increased SERCA activity and SERCA2 expression, and suppressed ER stress-mediated and mitochondria-mediated apoptosis in db/db mouse kidney. AS-IV also normalized glucose tolerance and insulin sensitivity, improved renal function, and ameliorated glomerulosclerosis and renal inflammation in db/db mice. In palmitate stimulated podocytes, AS-IV markedly improved inhibitions of SERCA activity and SERCA2 expression, restored intracellular Ca(2+) homeostasis, and attenuated podocyte apoptosis in a dose-dependent manner with a concomitant abrogation of ER stress as evidenced by the downregulation of GRP78, cleaved ATF6, phospho-IRE1 and phospho-PERK, and the inactivation of both ER stress-mediated and mitochondria-mediated apoptotic pathways. Furthermore, SERCA2b knockdown eliminated the effect of AS-IV on ER stress and ER stress-mediated apoptotic pathway, whereas its overexpression exhibited an anti-apoptotic effect. Our data obtained from in vivo and in vitro studies demonstrate that AS-IV attenuates renal injury in diabetes subsequent to inhibiting ER stress-induced podocyte apoptosis through restoring SERCA activity and SERCA2 expression.

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05:58

How to Get Rid of Stubborn Laundry Static Without Relying on Dryer Sheets Healthy Holistic Living

This article is shared with permission from our friends at Dr. Mercola. A dry climate or cold weather may increase the amount of static cling you find in your clothes. While this can be a nuisance in your sweaters, suits and shirts, common over-the-counter treatments may trigger damage to your...

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The post How to Get Rid of Stubborn Laundry Static Without Relying on Dryer Sheets appeared first on Healthy Holistic Living.

05:55

Study: Broccoli Good for Leaky Gut and Other Digestive Problems Health Impact News

Broccoli.Raw fresh broccoli on old wooden table.

by Paul Fassa
Health Impact News

Among cruciferous vegetables, which include cauliflower, cabbage, and Brussel sprouts, broccoli seems to be the most researched for its antioxidant, cancer preventative, and anti-carcinogen qualities.

A 2017 study at Penn State University was centered on how broccoli and cruciferous vegetables may affect gut health, including permeability or leaky gut and other gut disturbances.

Leaky gut or gut permeability has been brought to the forefront of medical concern since it has been determined to be a source of many other maladies. Two major reasons for this are:

1. It blocks nutrient absorption from the small intestines into the blood stream.

2. It allows toxins from ingested foods to escape the elimination process and enter the blood stream.

These two concerns align with what Dr. Max Gerson, who created the Gerson Therapy for cancer and chronic disease, had proposed circa 1950 as the major causes of cancer and other non-infectious diseases, insufficient nutrition and overwhelming environmental toxicity. More on leaky gut syndrome here.

2017 Study That Determined Broccoli Benefits Leaky Gut

Recent medical research has shown how the gut affects our overall health, beyond poor digestion.

The gut could be considered the center of good and bad health.

According to Penn State Professor of Agriculture Sciences Gary Perdew, who was involved with the study:

There are a lot of reasons we want to explore helping with gastrointestinal health and one reason is if you have problems, like a leaky gut, and start to suffer inflammation, that may then lead to other conditions, like arthritis and heart disease.

Keeping your gut healthy and making sure you have good barrier functions so youre not getting this leaky effect would be really big.

The study was titled Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner.

Right away were stuck with a term within the studys title Ah receptor. The code AHR is used within the st...

05:55

Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition. GreenMedInfo

PMID:  Oncol Rep. 2017 Mar ;37(3):1725-1735. Epub 2017 Jan 19. PMID: 28112375 Abstract Title:  Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition via the Akt/GSK-3/-catenin pathway. Abstract:  Our previous studies demonstrated that traditional Chinese herbal medicine 'Songyou Yin' inhibited the growth and invasion of hepatocellular carcinoma (HCC) cells, and altered epithelialmesenchymal transition (EMT) markers in oxaliplatintreated HCC tissues and cell lines. In the present study, we aimed to explore whether astragaloside IV (AS-IV), a component of 'Songyou Yin', can affect the growth and invasion of HCC cells and the underlying mechanism involved. Human HCC celllines Huh7 and MHCC97-H, with low and high metastatic potential, respectively, were treated with increasing doses of AS-IV. The Cell Counting Kit-8 (CCK-8), plate clone formation, Transwell, wound healing and immunofluorescence assays were used to investigate the effects of AS-IV on HCC cell proliferation, migration and invasion. The protein expression levels were analyzed by western blotting and immunofluorescence assay. The CCK-8 and plate clone formation assays showed that AS-IV had little effect on the proliferation of HCC cells in vitro. However, the Transwell and wound healing assays demonstrated that AS-IV inhibited the migration and invasion of HCC cells in a dose-dependent manner and the morphology of HCC cells was altered from spindle into oval shaped in the AS-IV pretreated groups. The upregulation of E-cadherin and downregulation of N-cadherin, vimentin, -SMA and Slug were also observed in the AS-IV pretreated groups. Additionally, AS-IV treatment resulted in a profound decrease in the phosphorylated forms of Akt and GSK-3, which in turn inhibited the expression of -catenin. Thus, we conclude that AS-IV attenuates the invasive and migratory abilities of HCC cells through the inhibition of EMT by targeting the Akt/GSK-3/-catenin pathway.

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05:54

Sacrificial Virgins: HPV Vaccine Documentary Reports Lawsuits from Japan to Colombia Increase Worldwide Health Impact News

Kristin Clulow

Australian Kristin Clulow, injured following treatment in 2008: I would like to say to them that what they are doing is unethical. They need to research their product they need to take it off the market and research it because what they are doing is hurting people this is a permanent brain injury that Ive had to live with for nine years.

Health Impact News Editor Comments

While lawsuits against the manufacturers of the HPV vaccine for injuries and deaths due to the HPV vaccine increase, there are none in the U.S., as vaccine manufacturers have legal immunity from lawsuits due to injuries or deaths from their vaccine products.

In addition, the mainstream corporate media in the U.S. censors anything negative related to vaccines, so one must look outside of the U.S. to fully understand the devastating consequences of this vaccine.

Sacrificial Virgins Part III: A Penny for Your Pain

LONDON, UK.

Manufacturers of the controversial HPV vaccines Gardasil and Cervarix routinely administered worldwide despite widespread calls for withdrawal on safety grounds will soon be sued in courts across the globe.

The topical film A penny for your pain that launched on October 18, (2017) on YouTube, describes how patients as far apart as Japan and Colombia are set to sue pharmaceutical giants Merck and GlaxoSmithKline for damages, following serious adverse reactions, with patient groups in the US, UK and Spain closely following the cases and Australian legal attention focused on prescribing doctors.

In A penny for your pain, eminent Japanese neurologist Dr. Hirokuni Beppu says:

At present about 120 persons are making law suits against pharmaceutical companies. It is now going on in eight cities in Japan and other additional people are also thinking to start.

hirokuni-beppu

Dr. Hirokuni Beppu, eminent Japanese neurologist: HPV vaccine is useless because it has very low risk benefit balance.

This follows a 2013 de...

05:50

You Only Need 2 Ingredients to Make This Anti-Wrinkle Solution Healthy Holistic Living

This article is shared with permission from our friends at Natural Living Ideas.  (Note: to find the eye cream mentioned in the headline, view remedy #6 below) For many people, the quest for younger-looking skin is a constant battle. Pharmaceutical companies have produced countless numbers of expensive pills, lotions, and...

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The post You Only Need 2 Ingredients to Make This Anti-Wrinkle Solution appeared first on Healthy Holistic Living.

05:37

13 Surprising Foods That Can Prevent You From Having a Flat Stomach Healthy Holistic Living

This article is shared with permission from our friends at AuthorityNutrition.  Bloating is when your belly feels swollen or enlarged after eating. It is usually caused by gas or other digestive issues (1). Bloating is very common. About 1630% of people say they experience it regularly (2, 3). Although bloating may...

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The post 13 Surprising Foods That Can Prevent You From Having a Flat Stomach appeared first on Healthy Holistic Living.

04:54

Sacrificial Virgins: HPV Vaccine Documentary Reports Lawsuits from Japan to Colombia Increase Worldwide Vaccine Impact

Kristin Clulow

Australian Kristin Clulow, injured following treatment in 2008: I would like to say to them that what they are doing is unethical. They need to research their product they need to take it off the market and research it because what they are doing is hurting people this is a permanent brain injury that Ive had to live with for nine years.

Health Impact News Editor Comments

While lawsuits against the manufacturers of the HPV vaccine for injuries and deaths due to the HPV vaccine increase, there are none in the U.S., as vaccine manufacturers have legal immunity from lawsuits due to injuries or deaths from their vaccine products.

In addition, the mainstream corporate media in the U.S. censors anything negative related to vaccines, so one must look outside of the U.S. to fully understand the devastating consequences of this vaccine.

Sacrificial Virgins Part III: A Penny for Your Pain

LONDON, UK.

Manufacturers of the controversial HPV vaccines Gardasil and Cervarix routinely administered worldwide despite widespread calls for withdrawal on safety grounds will soon be sued in courts across the globe.

The topical film A penny for your pain that launched on October 18, (2017) on YouTube, describes how patients as far apart as Japan and Colombia are set to sue pharmaceutical giants Merck and GlaxoSmithKline for damages, following serious adverse reactions, with patient groups in the US, UK and Spain closely following the cases and Australian legal attention focused on prescribing doctors.

In A penny for your pain, eminent Japanese neurologist Dr. Hirokuni Beppu says:

At present about 120 persons are making law suits against pharmaceutical companies. It is now going on in eight cities in Japan and other additional people are also thinking to start.

hirokuni-beppu

Dr. Hirokuni Beppu, eminent Japanese neurologist: HPV vaccine is useless because it has very low risk benefit balance.

This follows a 2013 decis...

04:36

Aloe Skin Cancer new research findings two

Research Finds Aloe Vera May Prevent and Treat Skin Cancer

Posted on: Friday, December 21st 2012 at 5:00 am
This article is copyrighted by GreenMedInfo LLC, 2017

Research from the University of Belgrade School of Medicine has confirmed what other recent studies have been finding that Aloe vera and its constituents inhibit the process of skin cell proliferation that accompanies skin cancer.
The researchers tested Aloe-emodin, a constituent of Aloe, with human skin cells keratinocytes after being treated with radiation. Once radiated, keratinocytes will typically proliferate in the process of forming skin tumors.
The researchers found that the Aloe-emodin significantly stopped the proliferation process. This confirmed Aloe's benefit in halting the progression of tumor formation after radiation by the sun.
This study confirms other recent findings. Researchers from South Korea's Gachon University of Medicine and Science found that Aloe-emodin specifically halted the growth of human cancerous liver cells. The researchers found that Aloe-emodin stimulated a genetic change within the cancerous cells that not only halted their expansion, but induced cell death among tumor cells.
In 2010, researchers from the China Medical University found this anticancer effect was not exclusive to Aloe's Aloe-emodin. The researchers found that Aloe constitents Emodin and Rhein also produced anticancer effects, which included the halting of tumor progression and cell death among cancer cells.
The research actually found this anticancer effect was greater with Emodin, as compared with Aloe-emodin and Rhein. But Aloe-emodin was observed having stronger cell repair abilities for those cells that had not become cancerous.

This illustrates what researchers from the Pharmacy School of the University of Belgrade found in...

04:31

Natural Substances that Fight Malignant Melanoma new research findings two

Natural Substances that Fight Malignant Melanoma

Posted on: Monday, October 16th 2017 at 3:00 pm
This article is copyrighted by GreenMedInfo LLC, 2017

Conventional medicine offers little hope in the fight against deadly malignant melanoma, but there are multiple foods, botanicals, and vitamins with proven anti-melanoma activity within natures pharmacopeia
Cutaneous malignant melanoma, one of the most aggressive types of tumors, accounts for 75% of death due to cancer, and its incidence is on the rise worldwide (1, 2). In North America, it has become the most prevalent form of cancer for the demographic aged 25 to 29 (3). When detected early, surgical excision of the primary site is the standard of care. However, metastatic melanoma, wherein the tumor cells detach from the primary growth and disseminate to distant organs, is notoriously resistant to conventional radiation, immunotherapy, and chemotherapy (3).
Even after surgical removal, recurrence is a distinct possibility, and therapies employed by the biomedical paradigm have limited success (4). Commonly employed treatments include the DNA alkylating chemotherapeutic agent, dacarbazine, which have response rates of 10 to 26%, most of which are partial, and are accompanied by side effects including anemia, nausea, neutropenia, and thrombocytopenia (5). More selective therapies such as BRAF inhibitors, targeted for the small percentage of advanced melanoma patients with a genetic BRAF V600 mutation, are associated with widespread resistance and the development of other cancers, including keratoacanthoma and squamous cell carcinoma, as side effects (6).
For metastatic melanoma, the five-year survival rate is dismal at less than 25% (6). However, there are evidence-based natural substances supported by the scientific liter...

04:25

Hundreds Of Families Block Organ Donations Vaxxter

The organ donation business has always been a controversial one, even though it doesnt often make major headlines. For various reasons, whether philosophical or religious, families of deceased relatives arent always comfortable with organ donations....

The post Hundreds Of Families Block Organ Donations appeared first on Vaxxter.

03:59

Scientists Now Say Our Brains Know When We Are DeadAnd So Do We. Vaxxter

Just in time for Halloween. Scientists are now trying to discover what happens after you die. Clearly, for many, this falls into a religious belief. For others, well, they just think the world goes blank....

The post Scientists Now Say Our Brains Know When We Are DeadAnd So Do We. appeared first on Vaxxter.

03:37

New Special Edition Of Fahrenheit 451 Must Be Heated To Be Read Natural Blaze

By Mac Slavo

The newest edition of the book Fahrenheit 451 is going to be out soon, and ironically, it must be heated up to be read.

For those who havent read the book Fahrenheit 451, its coming highly recommended.  It tells the story of a dystopian society in which books are outlawed and burned by firemen to prevent citizens from reading them. It follows one firemans journey of following orders and questioning authority. Ray Bradburys iconic book was originally published in 1953 and will leave a permanent reminder tucked away in the mind as to why free speech should never, under any circumstances, be culled. Simon and Schusters website says this is what the book is about:

Guy Montag is a fireman. In his world, where television rules and literature is on the brink of extinction, firemen start fires rather than put them out. His job is to destroy the most illegal of commodities, the printed book, along with the houses in which they are hidden.

Montag never questions the destruction and ruin his actions produce, returning each day to his bland life and wife, Mildred, who spends all day with her television family. But then he meets an eccentric young neighbor, Clarisse, who introduces him to a past where people didnt live in fear and to a present where one sees the world through the ideas in books instead of the mindless chatter of television.

When Mildred attempts suicide and Clarisse suddenly disappears, Montag begins to question everything he has ever known. He starts h...

03:08

These Specific Techniques Allow You To Control Your Dreams Natural Blaze

By April McCarthy

New research at the University of Adelaide has found that a specific combination of techniques will increase peoples chances of having lucid dreams, in which the dreamer is aware theyre dreaming while its still happening and can control the experience.

Dreams have fascinated philosophers for thousands of years, but only recently have dreams been subjected to empirical research and concentrated scientific study. Chances are that youve often found yourself puzzling over the mysterious content of a dream, or perhaps youve wondered why you dream at all.

Although many techniques exist for inducing lucid dreams, previous studies have reported low success rates, preventing researchers from being able to study the potential benefits and applications of lucid dreaming.

Although anecdotal reports of people awakening inside a dream have been around for centuries and over 50 percent of people report having at least one such experience in their lifetime, the first rigorous study of the phenomenon was only conducted in the last century.

Dr Denholm Aspys research in the University of Adelaides School of Psychology is aimed at addressing this problem and developing more effective lucid dream induction techniques.

...

02:31

Veterans Potentially Given Bad Flu Shots In San Diego Vaxxter

More than 1,500 veterans were possibly given compromised flu shots at a VA in San Diego. The excuse given? Bad refrigeration. VA staff caught the issue when they noticed that the refrigerator temperature had risen beyond...

The post Veterans Potentially Given Bad Flu Shots In San Diego appeared first on Vaxxter.

02:02

Cory Booker Grills Michael Dourson On Senate Floor Vaxxter

Cory Booker, the junior United States Senator from New Jersey, isnt a big fan of President Trumps nominee to lead the Environmental Protection Agency. The EPA, as it is known, is the office that handles...

The post Cory Booker Grills Michael Dourson On Senate Floor appeared first on Vaxxter.

00:23

Saffron Rice Recipe (Traditional Method) The Healthy Home Economist

saffron riceIf you want to find out how to make saffron rice, it isnt too difficult. Numerous recipes are at your fingertips if you do an online search, and they are all basically the same.

This recipe for saffron rice is different because it is made with traditionally prepared rice, which adds several unique and very important benefits. (...)
Read the rest of Saffron Rice Recipe (Traditional Method) (651 words)

The post Saffron Rice Recipe (Traditional Method) appeared first on The Healthy Home Economist.

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Friday, 20 October

23:19

Edgartons Board of Health to discuss fluoridation Fluoride Action Network

Edgarton is not fluoridated. According to the Board of Health agenda of October 24, 2017, fluoridation will be discussed.

The next meeting date for the BOH is November 28th.

More info on the BOH is here http://www.edgartown-ma.us/departments/health

See mention of Edgarton not fluoridating in this article.

23:00

The American Academy of Pediatrics has an Integrative Medicine Problem Science-Based Medicine

The American Academy of Pediatrics is usually a trustworthy source of high quality information for patients, caregivers, and pediatric medical providers. But when it comes to so-called integrative medicine, they have a massive biased blind spot. In this post, I discuss a recently updated clinical report from their Section on Integrative Medicine.

23:00

Estimate: Nearly 33,000 papers include misidentified cell lines. Experts talk ways to combat growing problem Retraction Watch

Although most researchers realize too many are using misidentified cell lines in their work, they may be shocked to see the scope of the problem: Approximately 32,755 articles report on research that relied on misidentified cells, according to a new report in PLoS ONE. And even though more people may be aware of the problem, it []

The post Estimate: Nearly 33,000 papers include misidentified cell lines. Experts talk ways to combat growing problem appeared first on Retraction Watch.

21:44

6 Nutrition and Healthcare Myths PreventDisease.com

Nutrition myths haven't changed much in nearly 40 years. The people making these erroneous assertions tend to be very dogmatic in their views. The source of these misleading facts is most often practising medical doctors untrained in nutritional medicine, or those who are just plain out of date. Here are the most widely known fake news items in natural medicine that die hard.

21:03

Im Reinventing Mental Health Care by Putting Patients in Charge Mad In America

In this piece for The Guardian, Joy Hibbins describes how her experiences of powerlessness as a mental health service user led her to start Suicide Crisis, a center that provides alternative approaches to mental health care.

A feeling of powerlessness dominated my experience of mental health services. And this feeling was at its worst when I was sectioned. Sectioning replicated aspects of the traumatic experience that initially caused my suicidal crisis. I felt trapped, captive and utterly out of control. I couldnt escape.

My experience of feeling disempowered when using mental health services is the reason we ensure our clients have a greater degree of control. They decide how often they see us, what kind of care they receive and when they are ready to leave us. Our male clients say they find this particularly helpful. They can feel especially vulnerable when they seek help; putting them in control helps to counteract this.

Article

21:02

Heres Why I Wouldnt Use the Mental Health System Mad In America

In this piece for The Spinoff, Graham Panther, a consultant in Australias mental health system, speaks to some of the shortcomings of mainstream mental health support. He introduces a new project he is starting, The Big Feels Club, on online peer support network.

What many people dont realise is there isnt just one way of talking about crisis and distress. Theres certainly one dominant way: the diagnostic model, in which doctor knows best. But there are a hundred other ways of making sense of bewildering, distressing experiences. Existential therapy, Intentional Peer Support, humanistic psychology, you name it. Many of them are much more optimistic about the value of human distress as part of a good life. I didnt know about any of these for years, and I didnt learn about them from the mental health system, I learned about them from other people going through it.

Thats why I want to make it much easier for people to find their tribe. I want people to have access to more ways of thinking about their big, uncomfortable feelings, so they can find what works for them. I want to create a resource that Id actually want to use!

21:01

How Stoicism can Help us Deal With Depression Mad In America

From Medical Xpress: Stoicism, an ancient philosophy based on the idea that the goal of life is to live in agreement with nature, can be helpful to those experiencing depression.

In all this, what these philosophers are reminding us is that to live in accord with nature is to recognize that even the most difficult of those we might run into in the course of a day could be someone like us someone perhaps struggling with their own malaise or malady.

Upon recognizing this, it is easier to be forgiving of those we disagree with. But more than that, perhaps, it makes it easier to be more forgiving of ourselves. It helps us recognize an important piece of suffering and of being human.

Article

21:00

Benzodiazepine Effects: Similarities With Childhood Trauma Mad In America

Benzodiazepines are a massive violation.

The expression that they are a rape of the mind, soul and body has been used for decades by campaigners in the UK for good reason.

The disabilities can start within weeks or even days for some. Personality changes occur and the body starts exhibiting side effects seldom attributed to the benzos, but more often than not, to stress, M.E., fibromyalgia or other virtually any other diagnosis. Effects can be severe causing loss of career, interpersonal relationships, violence, suicide and more contact with mental health services which, for some, has resulted in heinous labels, such as BPD or dependent personality disorder, and polydrugging.

The enormous and ever growing number of forums on social media for people damaged by both benzos and SSRI polydrugging bears out the truth that very many people are severely damaged by commonly trusted medications.

I turn now to the childhood abuse survivor community. Esther Rantzen is probably one of the few journalists in the country to have some in depth knowledge of these issues. She both established the helpline for victims of child abuse Childline and took up the cause of benzo victims who had written in to her TV programme Thats Life. Speaking in BBCs 2001 Panorama programme The Tranquilliser Trap she was clearly incensed that nothing had been done by governments or healthcare agencies to stop the benzodiazepine disaster.

These issues should absolutely be of priority for childhood abuse survivor charities in the UK. Survivors of childhood trauma who are also adversely affected by benzos need to be believed. Many sadly wont even know until its too late that symptoms, often categorized as stress from trauma, could in (some) cases be either partly or even entirely caused by benzos. For example, in my case, a deteriorating benzodiazepine induced brain injury that made me seem childlike was categorized as my inner child. When patients do disclose a benzodiazepine injury to their support networks in abuse survivor groups, it is imperative that they are believed. There also needs to be awareness that categorizing everything as somatisation is neither helpful nor safe. Again, many charity and patient groups from ME to thyroid charities are currently trying to raise awareness of the harms of the current medical paradigm, which far too often dismisses patients unseen illnesses as a psychiatric or psychological disorder.

Victims of severe childhood trauma have already been through far, far too much. Many find when they disclose abuse to GPs the first thing that happens is an instant prescription for an SSRI or benzodiazepine. It is worth noting here that a very small minority of people find themselves unable to walk and even wheel-chair bound after benzodiazepine discontinuation. Some even die. How can this level of risk...

21:00

Pediatric Autoimmune Neuropsychiatric Syndrome (PANS) or Autism? AGE OF AUTISM

By Teresa Conrick If there is one topic that has been increasing in the autism world, it is the issue of the immune system. To explore that further, the explosion of the microbiome research has been just phenomenal. The connection...

17:46

A case report of severe alcoholic hepatitis effectively treated with vitamin E as an add-on to corticosteroids. GreenMedInfo

PMID:  Intern Med. 2017 Oct 11. Epub 2017 Oct 11. PMID: 29021453 Abstract Title:  Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids. Abstract:  A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. The Japan alcoholic hepatitis score and Maddrey's discriminant function were 10 and 54 points, respectively. We diagnosed her with severe alcoholic hepatitis and treated her with corticosteroids, but her liver function did not improve. We therefore administered the vitamin E product tochopheryl acetate (150 mg/day) as an add-on therapy, after which her leukophilia, liver enzymes and coagulopathy improved immediately.

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17:38

Vitamin C and especially vitamin E may be useful in the repair and regeneration of oral hard and soft tissues in smokers. GreenMedInfo

PMID:  Eur J Oral Sci. 2017 Oct 12. Epub 2017 Oct 12. PMID: 29024129 Abstract Title:  Efficacy of vitamins E and C for reversing the cytotoxic effects of nicotine and cotinine. Abstract:  Nicotine has adverse cellular and molecular effects on oral mucosa, bone, and teeth. Vitamin E (-tocopherol) and vitamin C (ascorbic acid) are biological antioxidants with positive effects on wound healing and bone formation. This in vitro study sought to assess the cytotoxic effects of different concentrations of nicotine and cotinine (a metabolite of nicotine) on MG-63 osteoblast-like cells and human gingival fibroblasts (HGFs) in the presence and absence of antioxidant vitamins E and C (separately and combined). Cell viability and proliferation were assessed using the methyl thiazol tetrazolium (MTT) assay. Cell migration was assessed using the scratch test, and expression of apoptosis-related genes was quantitatively analyzed using real-time PCR. Dose-dependent negative effects of nicotine on the morphology, viability, proliferation, and migration of MG-63 and HGF cells were statistically significantly greater than those of cotinine. Vitamin E (separately and combined with vitamin C) was statistically significantly more effective than vitamin C (at the concentration used in this study) at improving cell viability, proliferation, and migration, and at reducing apoptosis of cells exposed to nicotine or cotinine. Based on the positive results of this study, vitamin C and especially vitamin E (systemically and/or locally) may be useful in the repair and regeneration of oral hard and soft tissues in smokers.

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17:17

Recovering from Psychiatry Mad In America

Recovering from Psychiatry is a website created by psychiatric survivor Laura Delano for those who believe in or want to explore life beyond psychiatric labels and psychotropic drugs. The site features Delanos personal story of coming off psychiatric drugs and healing from psychiatric oppression, as well as extensive advice on tapering from psychiatric drugs. You can also find information on food and health and original poetry written by Laura Delano.

16:59

The Council for Evidence-Based Psychiatry Mad In America

The Council for Evidence-Based Psychiatry (CEP) exists to communicate evidence of the potentially harmful effects of psychiatric drugs to the people and institutions in the UK that can make a difference. The CEPs members include psychiatrists, academics, withdrawal support charities, and others who are concerned about the prevalence of the medical model and the increasing number of prescriptions for psychiatric drugs being given to both adults and children.

The CEPs website provides substantial information on withdrawal. Its Withdrawal Advisers section features videos from withdrawal counselors and people with lived experience of psychiatric drug withdrawal that provide information about withdrawal symptoms and tapering advice. Additionally, the Recovery Videos section features videos from several people who have successfully tapered from psychiatric drugs.

16:46

benzo.org.uk Mad In America

benzo.org.uk is a website dedicated to sufferers of iatrogenic benzodiazepine tranquilliser addiction. Launched on July 6th, 2000, the site consists of articles, information, expert medical documents, news stories, and personal accounts. The front page of the site features a statement from the prime minister on benzodiazepine addiction. Other sections of the site include:

  • Litigation: A listing of recent lawsuits concerning benzodiazepines
  • Media: A listing of media coverage of benzodiazepines
  • Stories: Personal accounts of benzodiazepine use and withdrawal
  • Doctors and Experts: Research and studies on the effects of benzodiazepines

16:38

Beating Benzos Mad In America

Beating Benzos is a website created by a benzodiazepine survivor to provide information, help, and encouragement for those who have been prescribed benzodiazepine drugs and are in the process of tapering from these or have already withdrawn. The website includes the site creators own story and drug history, as well as several blog posts documenting the site creators recovery. Other sections include:

  • Possible Symptoms
  • Food and Diet
  • Coping Tips
  • A Guide for Carers
  • Benzo Stories
  • Success Stories
  • Words of Hope
  • What the Doctors Say

16:31

Battle Against Tranquillisers Mad In America

Battle Against Tranquillisers is an organization created to lessen the harm caused by benzodiazepine and Z drug tranquillisers and sleeping pills. The organizations stated aims are:

  • To help those who are addicted to benzodiazepines, tranquillisers and sleeping pills, and drugs with similar effects, and who wish to withdraw from them, to do so as comfortably as possible, and to help them to make the changes necessary in life after withdrawal.
  • To educate and inform all those who may come across the problem of BZ etc. addiction, either personally or professionally, towards an understanding of the difficulties caused by the drugs action and the compounding of these difficulties in withdrawal.
  • To influence services in their prescribing, managing and supporting of clients who take/want to withdraw from benzodiazepines and similar drugs.

Battle Against Tranquillisers provides direct services to users and carers through local support groups, drop-ins, home visits, a peer support line, and technical support for agencies and workers. They also provide public education through presentations and their website.

The websites About Benzos section includes information about a variety of topics related to benzos such as withdrawal symptoms, dependency, the history of benzos, and benzos and driving. The I Need Help section describes the organizations direct services in depth and provides information about how to access those services. The section also includes client stories and testimonials.

The website also answers some frequently asked questions about benzodiazepines, such as how long withdrawal symptoms typically last and how to taper from tranquillisers.

15:44

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control. GreenMedInfo

PMID:  Anticancer Res. 2017 02 ;37(2):465-473. PMID: 28179291 Abstract Title:  Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Abstract:  AIM: The aim of the present study was to investigate the efficacy of the traditional Chinese medicine (TCM), astragaloside IV (AS-IV) and curcumin on tumor growth and angiogenesis in an orthotopic nude-mouse model of human hepatocellular carcinoma (HCC). We have previously shown the usefulness of orthotopic models of human cancer for evaluation of the efficacy of TCM.MATERIALS AND METHODS: Nude mice with orthotopic HepG2 HCC were treated with vehicle control (0.01 ml/g normal saline), cisplatinum (2 mg/kg), AS-IV (20 mg/kg), curcumin (100 mg/kg) or AS-IV plus curcumin (20 mg/kg + 100 mg/kg). Tumor inhibition in each group was evaluated by tumor weight at autopsy. The effect of AS-IV and curcumin on tumor angiogenesis was assessed by CD34 staining and expression of fibroblast growth factor-2 (FGF2), matrix metalloproteinase 2 (MMP2), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), thrombosis-related factor tissue factor (TF) and coagulation factor VII (FVII), as well as microRNAs miR-122 and miR-221.RESULTS: AS-IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control (p

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15:24

Combination of astragaloside IV and ginsenoside Rg1 had a synergistic inhibition on autophagic injury. GreenMedInfo

PMID:  Biomed Pharmacother. 2017 May ;89:124-134. Epub 2017 Feb 20. PMID: 28219050 Abstract Title:  Synergism and mechanism of Astragaloside IV combined with Ginsenoside Rg1 against autophagic injury of PC12 cells induced by oxygen glucose deprivation/reoxygenation. Abstract:  The aim of this study was to explore the effect by which the combination of Astragaloside IV (AST IV) and Ginsenoside Rg1 (Rg1) resisted autophagic injury in PC12 cells induced by oxygen glucose deprivation/reoxygenation (OGD/R). We studied the nature of the interaction between AST IV and Rg1 that inhibited autophagy through the Isobologram method, and investigated the synergistic mechanism via the PI3K I/Akt/mTOR and PI3K III/Becline-1/Bcl-2 signaling pathways. Our results showed that, based on the 50% inhibiting concentration (IC50), AST IV combined with Rg1 at a 1:1 ratio resulted in a synergistic effect, whereas the combination of the two had an antagonistic effect on autophagy at ratios of 1:2 and 2:1. Meanwhile, AST IV and Rg1 alone increased cell survival and decreased lactate dehydrogenase (LDH) leakage induced by OGD/R, reduced autophagosomes and the LC3 II positive patch, down-regulated the LC3 II/LC3 I ratio and up-regulated the p62 protein; the 1:1 combination enhanced these effects. Mechanistic study showed that Rg1 and the 1:1 combination increased the phosphorylation of PI3K I, Akt and mTOR; the effects of the combination were greater than those of the drugs alone. AST IV and the 1:1 combination suppressed the expression of PI3K III and Becline-1, and the combination elevated Bcl-2 protein expression; the effects of the combination were better than those of the drugs alone. These results suggest that after 2 h-OGD followed by reoxygenation for 24h, PC12 cells suffer excessive autophagy and damage, which are blocked by AST IV or Rg1; moreover, the combination of AST IV and Rg1 at a 1:1 ratio of their IC50 concentrations has a synergistic inhibition on autophagic injury. The synergistic mechanism may be associated with the PI3K I/Akt/mTOR and PI3K III/Becline-1/Bcl-2 signaling pathways.

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15:03

Astragaloside alleviates hepatic fibrosis by inhibiting PAR2 signalling expression. GreenMedInfo

PMID:  Cell Physiol Biochem. 2017 ;41(3):1156-1166. Epub 2017 Feb 28. PMID: 28245465 Abstract Title:  Astragaloside Alleviates Hepatic Fibrosis Function via PAR2 Signaling Pathway in Diabetic Rats. Abstract:  BACKGROUND/AIMS: Astragaloside (AGS) extracted from radix astragalin (Huangqi) has been considered to be beneficial to liver diseases. In this study, we examined the role played by AGS in alleviating hepatic fibrosis function via protease-activated receptor-2 (PAR2) mechanisms. We hypothesized that AGS affects PAR2 signaling pathway thereby improving hepatic function in rats with hepatic fibrosis induced by carbon tetrachloride (CCl4). We further hypothesized that AGS attenuates impaired hepatic function evoked by CCl4 to a greater degree in diabetic animals.METHODS: ELISA and Western Blot analysis were used to examine PAR2 signaling pathway in diabetic CCl4-rats and non-diabetic CCl4-rats.RESULTS: AGS inhibited the protein expression of PAR2 and its downstream pathway PKA and PKC in CCl4-rats. Notably, the effects of AGS were greater in CCl4-rats with diabetes. AGS also significantly attenuated the CCl4-induced upregulations of pro-inflammatory cytokines, namely interleukin-1, interleukin-6 and tumor necrosis factor- accompanied with decreases of collagenic parameterssuch as hexadecenoic acid, laminin and hydroxyproline. Additionally, AGS improved the CCl4-induced exaggerations of liver index and functions including alanine aminotransferase, aspartate aminotransferase. Moreover, TGF-1, a marker of hepatic fibrosis, was increased in CCl4-rats and AGS inhibitedincreases in TGF-1 induced by CCl4.CONCLUSIONS: AGS alleviates hepatic fibrosis by inhibiting PAR2 signaling expression and its effects are largely enhanced in diabetic animals. Targeting one or more of these signaling molecules may present new opportunities for treatment and management of hepatic fibrosis; and results of our study are likely to shed light on strategies for application of AGS because it has potentially greater therapeutic effectiveness for hepatic fibrosis in diabetes.

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14:32

Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil. GreenMedInfo

PMID:  J Pharm Pharmacol. 2017 Jun ;69(6):743-752. Epub 2017 Mar 7. PMID: 28266023 Abstract Title:  Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy. Abstract:  OBJECTIVES: Inhibition of autophagy has been increasingly recognized as a potential therapeutic approach against cancer. Our previous reports showed that Astragaloside II improves hepatic cancer cells resistance by downregulating MDR1 and P-gp .The purpose of this study was to further investigated the effect of autophagy on AS-II reversing multidrug resistance and its molecular mechanism in hepatocellular carcinoma cells in vitro.METHODS: Bel-7402 and Bel-7402/FU cell lines were used in this study. Western blot was used to detect the expression of autophagy-related protein, p-mTOR and p-p79s6k, MTT was used to analyse cell viability, GFP-LC3 punctate dots distribution was observed by GFP-LC3 transient transfection under fluorescence microscopy and silencing of autophagy-related genes was detected by small interfering RNA transfection.KEY FINDINGS: Astragaloside II was able to significantly decrease the expression of LC3-II and Beclin-1 in a dose-dependent manner, Astragaloside II (80m) further decreased LC3-II formation, Beclin-1 and GFP-LC3 puncta dots stimulated with 5-fluorouracil (0.2 mm) in Bel-7402/FU cells (P

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14:25

Veterans with gulf war illness exhibit greater mitochondrial DNA damage which is consistent with mitochondrial dysfunction. GreenMedInfo

PMID:  PLoS One. 2017 ;12(9):e0184832. Epub 2017 Sep 14. PMID: 28910366 Abstract Title:  Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. Abstract:  Gulf War Illness (GWI) is a chronic multi-symptom illness not currently diagnosed by standard medical or laboratory test that affects 30% of veterans who served during the 1990-1991 Gulf War. The clinical presentation of GWI is comparable to that of patients with certain mitochondrial disorders-i.e., clinically heterogeneous multisystem symptoms. Therefore, we hypothesized that mitochondrial dysfunction may contribute to both the symptoms of GWI as well as its persistence over time. We recruited 21 cases of GWI (CDC and Kansas criteria) and 7 controls to participate in this study. Peripheral blood samples were obtained in all participants and a quantitative polymerase chain reaction (QPCR) based assay was performed to quantify mitochondrial and nuclear DNA lesion frequency and mitochondrial DNA (mtDNA) copy number (mtDNAcn) from peripheral blood mononuclear cells. Samples were also used to analyze nuclear DNA lesion frequency and enzyme activity for mitochondrial complexes I and IV. Both mtDNA lesion frequency (p = 0.015, d = 1.13) and mtDNAcn (p = 0.001; d = 1.69) were elevated in veterans with GWI relative to controls. Nuclear DNA lesion frequency was also elevated in veterans with GWI (p = 0.344; d = 1.41), but did not reach statistical significance. Complex I and IV activity (p>0.05) were similar between groups and greater mtDNA lesion frequency was associated with reduced complex I (r2 = -0.35, p = 0.007) and IV (r2 = -0.28, p

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13:57

Astragaloside IV enhances cisplatin chemosensitivity in human colorectal cancer. GreenMedInfo

PMID:  Oncol Res. 2016 Oct 27 ;24(6):447-453. PMID: 28281965 Abstract Title:  Astragaloside IV Enhances Cisplatin Chemosensitivity in Human Colorectal Cancer via Regulating NOTCH3. Abstract:  Although astragaloside IV exhibits anti-inflammation, immunoregulatory, and anticancer properties, the chemosensitization effects of astragaloside IV in colorectal cancer have never been reported. Our study tested whether astragaloside could increase cisplatin sensitivity in colorectal cancer. CCK-8 assay was used to measure the cell viability of colorectal cancer cells. Quantitative real-time PCR and Western blot were performed to determine the mRNA and protein expression, respectively. Our data revealed that astragaloside IV administration significantly suppressed the cell growth of colorectal cancer cells, whereas no obvious cytotoxicity of astragaloside IV was observed in nonmalignant colonic cells. In addition, combined treatment with astragaloside IV dramatically elevated the chemosensitivity of colorectal cancer cells to cisplatin. Mechanical investigation revealed that the mRNA and protein expression of NOTCH3 was significantly lower in cisplatin and astragaloside IV-treated cells compared with cells treated with cisplatin alone. On the contrary, no obvious changes in tumor cell growth were shown after upregulation of NOTCH3 whether in the presence or absence of astragaloside IV. Thus, our data demonstrate that astragaloside IV increases the chemosensitivity of colorectal cancer cells to cisplatin, at least partly, through inhibition of NOTCH3. This study suggests that combined therapy with astragaloside IV might be a novel therapeutic approach for colorectal cancer.

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13:44

Astragaloside IV exerted a possible neuroprotective effect during the cerebral ischemia-reperfusion injury. GreenMedInfo

PMID:  Oxid Med Cell Longev. 2017 ;2017:8424326. Epub 2017 Feb 20. PMID: 28303172 Abstract Title:  Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms. Abstract:  Astragaloside IV (AST-IV) is a principal component of Radix Astragali seu Hedysari (Huangqi) and exerts potential neuroprotection in experimental ischemic stroke. Here, we systematically assessed the effectiveness and possible mechanisms of AST-IV for experimental acute ischemic stroke. An electronic search in eight databases was conducted from inception to March 2016. The study quality score was evaluated using the CAMARADES. Rev Man 5.0 software was used for data analyses. Thirteen studies with 244 animals were identified. The study quality score of included studies ranged from 3/10 to 8/10. Eleven studies showed significant effects of AST-IV for ameliorating the neurological function score (P

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13:36

Astragaloside IV may be a promising candidate for the treatment of lead developmental neurotoxicity. GreenMedInfo

PMID:  Biochim Biophys Acta. 2017 Jun ;1863(6):1195-1203. Epub 2017 Mar 14. PMID: 28315454 Abstract Title:  Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro. Abstract:  Recently, oxidative stress is strongly associated with lead (Pb)-induced neurotoxicity. We reported previously that Astragaloside IV (AS-IV) possesses potent antioxidant properties. Here, we evaluate the hypothesis that AS-IV attenuates lead acetate (PbAc)-mediated inhibition of neurite outgrowth might mainly result from its antioxidant property via serine/threonine protein kinase (Akt)-dependent activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Interestingly, AS-IV attenuates PbAc-induced inhibition of neurite outgrowth and displayed potential antioxidant properties by inhibiting reactive oxygen species (ROS). Concomitantly, AS-IV enhanced phase II detoxifying enzymes such as heme oxygenase 1 (HO-1), thioredoxin reductase (TrxR), and glutamate cysteine ligase catalytic subunit (GCLc). Conversely, AS-IV had no effect on GCL modulatory subunit (GCLm) and superoxide dismutase (SOD) activity/expression. Furthermore, AS-IV evoked Akt phosphorylation, and subsequent induced phosphorylation of glycogen synthase kinase-3 (GSK-3) at Ser9 (that is, inactivation), which stimulated Nrf2-mediated antioxidant response element (ARE)-containing activation. Importantly, Akt locates upstream of GSK-3 and regulates phase II detoxifying enzymes gene expression through Nrf2 nuclear accumulation in PC12 cells exposed to PbAc. Noteworthy, these results were further confirmed through signalling pathway inhibitors, dominant negative mutant and short hairpin RNA technology. Collectively, these in vitro findings suggest that AS-IV attenuates PbAc-induced inhibition of neurite outgrowth attributed to its antioxidant properties and may be a promising candidate for the treatment of lead developmental neurotoxicity.

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13:00

Astragaloside IV alleviates lipopolysaccharide-induced acute kidney injury. GreenMedInfo

PMID:  Med Sci Monit. 2017 Mar 22 ;23:1413-1420. Epub 2017 Mar 22. PMID: 28328867 Abstract Title:  Astragaloside IV Alleviates Lipopolysaccharide-Induced Acute Kidney Injury Through Down-Regulating Cytokines, CCR5 and p-ERK, and Elevating Anti-Oxidative Ability. Abstract:  BACKGROUND Astragaloside IV (AS-IV) has been shown to prevent ischemia-induced acute kidney injury (AKI) in rat models of ischemia and reperfusion. However, the effects of AS-IV on AKI during sepsis and endotoxinemia is unclear. The current study aimed to investigate the effects and molecular mechanisms of AS-IV on lipopolysaccharide (LPS)-induced AKI. MATERIAL AND METHODS Adult male CD-1 mice were randomly assigned into 6 groups (n=8/group): control group: mice were intraperitoneally (i.p.) injected with normal saline; LPS group (10 mg/kg, i.p.); low-dose AS-IV (25 mg/kg; gavage for 7 days) + LPS (i.p., 1 hour after last gavage) group; medial-dose AS-IV (50 mg/kg) + LPS group; high-dose AS-IV (100 mg/kg) + LPS group; high-dose AS-IV alone (100 mg/kg; gavage for 7 days) group. Blood samples were collected at 24 hours after LPS injection, and plasma uric acid and BUN were measured with colorimetric detection kits. The concentration of plasma tumor necrosis factor (TNF)- and interleukin 1, renal p-extracellular signal-regulated kinases, and urinary albumin were evaluated by ELISA. The expression of CCR5 in renal tissue was evaluated by PCR and Western blotting. Concentrations of glutathione (GSH) and reactive oxygen species (ROS) in renal tissue were also measured. RESULTS AS-IV decreased LPS-stimulated production of blood TNF- and IL-6, LPS-induced the expression of CCR5, and activation of ERK in the kidneys in a rodent model of endotoxinemia. AS-IV attenuated LPS-caused decreased GSH and increased ROS. It also attenuated LPS-induced increases in plasma uric acid, BUN, and urinary albumin. CONCLUSIONS AS-IV protects against AKI during bacterial endotoxinemia by attenuating expression of cytokines, CCR5, and p-ERK, and elevating anti-oxidative ability.

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12:49

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes. GreenMedInfo

PMID:  Acta Pharmacol Sin. 2017 Jul ;38(7):998-1008. Epub 2017 Mar 27. PMID: 28344322 Abstract Title:  Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation. Abstract:  Although the pathogenesis of non-alcoholic fatty liver disease (NAFLD) is not completely understood, the increased influx of free fatty acids (FFAs) into the liver and the FFA-induced hepatic endoplasmic reticulum (ER) stress are two crucial pathogenic processes in the initiation and development of NAFLD. In this study we investigated the effects of astragaloside IV (AS-IV), a bioactive compound purified from Astragali Radix, on FFA-induced lipid accumulation in hepatocytes and elucidated the underlying mechanisms. Human HepG2 cells and primary murine hepatocytes were exposed to FFAs (1 mmol/L, oleate/palmitate, 2:1 ratio) with or without AS-IV for 24 h. Exposure to FFAs induced marked lipid accumulation in hepatocytes, whereas co-treatment with AS-IV (100g/mL) significantly attenuated this phenomenon. Notably, AS-IV (50-200 g/mL) concentration-dependently enhanced the phosphorylation of AMPK, acetyl-CoA carboxylase (ACC) and SREBP-1c, inhibited the accumulation and nuclear translocation of mature SREBP-1 and subsequently decreased the mRNA levels of lipogenic genes including acc1, fas and scd1. AS-IV treatment also concentration-dependently attenuated FFA-induced hepatic ER stress evidenced by the reduction of the key markers, GRP78, CHOP and p-PERK. Pretreated the cells with the AMPK inhibitor compound C (20 mol/L) greatly diminished these beneficial effects of AS-IV. Our results demonstrate that AS-IV attenuates FFA-induced ER stress and lipid accumulation in an AMPK-dependent manner in hepatocytes, which supports its use as promising therapeutics for hepatic steatosis.

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12:44

Astragaloside IV may be used as a natural medicine to treat EPCR-related systemic inflammation and cardiovascular diseases. GreenMedInfo

PMID:  Immunopharmacol Immunotoxicol. 2017 Jun ;39(3):148-156. Epub 2017 Apr 3. PMID: 28367652 Abstract Title:  Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway. Abstract:  Astragaloside IV (AS-IV), a main active substance isolated from Astragalus membranaceus Bunge, has been shown to have multiple pharmacological effects. Endothelial cell protein C receptor (EPCR) is a marker of inflammation, and is also a major member of protein C (PC) anti-coagulation system. EPCR can be cut off from the cell surface by tumor necrosis factor- converting enzyme (TACE), which is controlled through mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) pathways. To develop novel therapeutic drug for EPCR shedding, the effect of AS-IV was studied in phorbol-12-myristate 13-acetate (PMA)-induced human umbilical vein endothelialcells (HUVECs) and the potential molecular mechanism of AS-IV action was investigated. The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding. In further study, AS-IV suppressed the expression and activity of TACE. In addition, AS-IV could decrease the phosphorylation of MAPK such as janus kinase (JNK) and p38, and inhibit activation of PKC through the prevention of non-phosphorylation and phosphorylation of specific PKC isoforms in PMA-stimulated HUVECs. These findings indicate that AS-IV may be used as a natural medicine to treat EPCR-related systemic inflammation and cardiovascular diseases by targeting MAPK and PKC pathway.

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12:36

Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib. GreenMedInfo

PMID:  Tumour Biol. 2017 Apr ;39(4):1010428317697555. PMID: 28443459 Abstract Title:  Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6. Abstract:  Astragaloside IV, the active component of Astragalus membranaceus, exhibits diverse biological roles including the anti-tumor activity. In this study, we evaluated the chemosensitive role of astragaloside IV in non-small cell lung cancer cells. Cell Counting Kit-8 analysis was performed to determine cell viability. Real-time polymerase chain reaction and western blot were used to measure the messenger RNA and protein expression. Results showed that astragaloside IV treatment could suppress the proliferation of non-small cell lung cancer cells. In addition, combined treatment with astragaloside IV remarkably enhanced the chemosensitivity to gefitinib in three non-small cell lung cancer cell lines including NCI-H1299, HCC827, and A549. Furthermore, compared with gefitinib-treated cells, the messenger RNA expression of SIRT6 was obviously increased in non-small cell lung cancer cells treated with gefitinib combined with astragaloside IV. In addition, downregulation of SIRT6 was accomplished using small interference RNA technology. As a result, SIRT6 inhibition abolished the sensitization role of astragaloside IV in non-small cell lung cancer cells. Taken together, these data demonstrated that astragaloside IV sensitized tumor cells to gefitinib via regulation of SIRT6, suggesting that astragaloside IV may serve as potential therapeutic approach for lung cancer.

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12:31

Astragaloside attenuates myocardial injury. GreenMedInfo

PMID:  Mol Med Rep. 2017 Jun ;15(6):4015-4020. Epub 2017 Apr 27. PMID: 28487976 Abstract Title:  Astragaloside attenuates myocardial injury in a rat model of acute myocardial infarction by upregulating hypoxia inducible factor1 and Notch1/Jagged1 signaling. Abstract:  The present study aimed to investigate the mechanisms underlying the cardioprotective effect of Astragaloside against myocardial injury following myocardial infarction (MI) in a rat model. Male Wistar rats were subjected to left anterior descending branch ligation. The rats that survived 24 h (n=18) were randomly and equally assigned to three groups: MI model group, and 2.5 and 10 mg/kg/day Astragaloside group. A further six rats underwent identical surgical procedures without artery ligation, serving as sham controls. Following 28 days of treatment, the left ventricle was harvested for morphological analysis, and mRNA and protein expression levels of hypoxia inducible factor1 (HIF1), Notch1 and Jagged1 were measured. Treatment with Astragaloside attenuated pathological changes in the myocardium. Compared with untreated MI rats, rats treated with Astragaloside exhibited significantly increased mRNA expression levels of HIF1, Notch1 and Jagged1 (all P

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12:13

Astragaloside was beneficial against cardiac fibrosis. GreenMedInfo

PMID:  Phytomedicine. 2017 Jul 1 ;30:10-17. Epub 2017 Apr 19. PMID: 28545665 Abstract Title:  Astragaloside against cardiac fibrosis by inhibiting TRPM7 channel. Abstract:  BACKGROUND: Astragaloside (ASG-, (Fig. 1) is the most active component of Chinese sp. Astragalus membranaceus Bunge (Fabaceae) that has showed antioxidant, antiapoptotic and antiviral activities among others. It is reported to play an important role in cardiac fibrosis (CF), but the mechanism remains unclear.PURPOSE: To investigate the mechanism of ASG- on inhibiting myocardial fibrosis induced by hypoxia.STUDY DESIGN: We studied the relationship between anti-fibrotic effect of ASG- and transient receptor potential cation channel, subfamily M, member 7 (TRPM7) by in vivo and in vitro experiments.METHODS: In vivo, CF was induced by subcutaneous isoproterenol (ISO) for 10 days. Rat hearts were resected for histological experiment and reverse transcription real-time quantitative poly merase chain reaction (RT-qPCR). In vitro, molecular and cellular biology technologies were used to confirm the anti-fibrosis effect underlying mechanism of ASG-.RESULTS: Histological findings and the collagen volume fraction showed that ASG- decreased fibrosis in heart tissues. Hypoxia could stimulate the proliferation and differentiation of cardiac fibroblast which indicated that the degree of fibrosis was increased significantly. Anoxic treatment could also obviously up-regulate the expression of TRPM7 protein and current. ASG-groups showed the opposite results. Knock-down TRPM7 experiment further confirmed the role of TRPM7 channel in hypoxia-induced cardiac fibrosis.CONCLUSION: Our results suggest that the inhibition of hypoxia-induced CF in vivo and in vitro by ASG-IV is associated with reduction of the expression of TRPM7. The moderate inhibition of the TRPM7 channel may be a new strategy for treating cardiac fibrosis.

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11:50

Astragaloside IV alleviates heart failure via activating PPAR to switch glycolysis to fatty acid -oxidation. GreenMedInfo

PMID:  Sci Rep. 2017 Jun 2 ;7(1):2691. Epub 2017 Jun 2. PMID: 28578382 Abstract Title:  Astragaloside IV alleviates heart failure via activating PPAR to switch glycolysis to fatty acid -oxidation. Abstract:  In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid-oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic reticulum Ca(2+) ATPase (SERCA) expression is downregulated and mitochondrial function is reduced in HF, perhaps partly due to a substantially reduced energy supply for excitation-contraction coupling resulting from a lower fatty acid -oxidation rate. We investigated whether Astragaloside IV can activate peroxisome proliferator-activated receptor alpha (PPAR) to stimulate fatty acid -oxidation and increase cardiac energy production, improving mitochondrial function and the efficiency of SERCA in HF. In pressure overload-induced HF mice and isolated hypertrophic myocardial cells, fatty acid -oxidation and heart function were substantially strengthened following Astragaloside IV treatment, as demonstrated by the increased expression of PPAR and SERCA2a. In vitro, Astragaloside IV regulated energy metabolism by increasing ATP production and enhancing mitochondrial function, attributable to increased oxygen consumption and slightly increased mitochondrial Ca(2+) uptake. In HF, Astragaloside IV switched glycolysis to fatty acid -oxidation, as confirmed by reduced anaerobic glycolysis andan increased oxygen consumption ratio. These results suggest that Astragaloside IV can stimulate fatty acid -oxidation and improve mitochondrial function, which may present a novel cardioprotective treatment that inhibits the progress of HF.

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11:44

The results shows that astragalosides and curcumin could lower the abnormal blood glucose levels and GSP levels. GreenMedInfo

PMID:  Saudi Pharm J. 2017 May ;25(4):477-481. Epub 2017 Apr 28. PMID: 28579878 Abstract Title:  The effect of different proportions of astragaloside and curcumin on DM model of mice. Abstract:  This paper aims to study the effects of different proportion of astragaloside and curcumin on STZ induced Diabetes Mellitus (DM) model of mice, and to select a better proportion of active components. Its ultimate purpose is to lay a basis for the follow-up research on astragaloside-curcumin capsule. Increase-decrease baseline geometric proportion design method and comprehensive performance evaluation utilised to study the effect of different proportion of astragaloside and curcumin on DM mice models, which have an intravenous tail injection of STZ. The proportions of the two components are 10:0, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 0:10 respectively. And we will screen out the optimal composition. Blood glycated serum protein (GSP), hepatic glycogen and insulin tested to observe pathological changes in the pancreas. The mice DM model was copied successfully. Compared with the model group, groups treated with the metformin and with different proportions of astragaloside and curcumin help lower the blood glucose levels and GSP levels, increase glycogen stores of model mice by different degrees, and avoid pathological changes of pancreas in the model mice. The ratio of 3:7 was selected as the optimal one, based on the comprehensive performance evaluation method, followed by the ratio of 4:6. The optimal proportion of DM models is 3:7, followed by 4:6. The ratio of total astragaloside and curcumin can lower blood glucose levels, GSP levels, promote the formation of glycogen, and improve the pathological changes of pancreas in the model mice.

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11:00

Astragaloside IV may represent an alternative therapeutic approach for the treatment of patients with allergic rhinitis. GreenMedInfo

PMID:  Mol Med Rep. 2017 Aug ;16(2):1207-1215. Epub 2017 Jun 6. PMID: 28586019 Abstract Title:  Protective effects of astragaloside IV against ovalbumin-induced allergic rhinitis are mediated by T-box protein expressed in T cells/GATA-3 and forkhead box protein 3/retinoic acid-related orphan nuclear receptort. Abstract:  3-O--D-xylopyranosyl-6-O--D-glucopyranosyl-cycloastragenol, or Astragaloside IV (AST), is one of the major active ingredients isolated from Astragalus membranaceous with distinct pharmacological effects, and possesses anti-inflammatory, immunoregulatory and antifibrotic properties. However, the effects of AST on allergic rhinitis remain to be elucidated. The present study aimed to examine the effects of AST on immunoglobulin (Ig) Emediated allergic reactions in vivo, by using a mouse model of allergic rhinitis established via repetitive sensitization and intranasal challenge with ovalbumin(OVA). Intragastric administration of AST (25 mg/kg or 50 mg/kg) or dexamethasone (DEX; 3 mg/kg) significantly alleviated the inflammatory response, nasal symptoms and mucosa remodeling, and decreased the serum levels of OVAspecific IgE in allergic mice. Furthermore, treatment with AST or DEXsignificantly suppressed the mRNA and protein expression levels of the transcription factor GATA3 and retinoic acid receptorrelated orphan nuclear receptor (ROR)t in tissue samples isolated from the spleen and nasal mucosa of mice with allergic rhinitis. Conversely, mRNA and protein expression levels of Tbox protein expressed in T cells (Tbet) and forkhead box protein 3 (Foxp3) were upregulated in the spleen and nasal mucosa of mice with allergic rhinitis following treatment with AST or DEX, and spleen protein levels of signal transducer and activator of transcription 3 followeda similar trend. In addition, treatment with AST was associated with fewer adverse events compared with treatment with DEX. The present results suggested that treatment with AST may attenuate OVAinduced allergic rhinitis via regulating the expression of the transcription factors GATA3, RORt, Tbet and Foxp3, which commit T helper cells to the Th1 phenotype. Therefore, AST may represent an alternative therapeutic approach for the treatment of patients with allergic rhinitis.

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10:53

Were Energy Drinks The Cause Of This Severe Head Trauma? Natural Blaze

 

Her claims have been controversial, but shes just lucky her husband is alive.

Credit: Sara Endres

During a pregnancy, women often want a support group consisting of their partner, family, and friends in order to get through the difficult parts of being pregnant.

When Brianna, a young woman who did not reveal her last name, got pregnant this past year, she was initially surrounded by this same group and was confident going into her pregnancy. Then, suddenly, her whole life changed...

10:50

Astragaloside-IV alleviates heat-induced inflammation. GreenMedInfo

PMID:  Cell Physiol Biochem. 2017 ;42(2):824-837. Epub 2017 Jun 23. PMID: 28641278 Abstract Title:  Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy. Abstract:  BACKGROUND: Thermal injury is the main cause of pulmonary disease in stroke after burn and can be life threatening. Heat-induced inflammation is an important factor that triggers a series of induces pathological changes. However, this mechanism underlying heat-induced inflammation in thermal inhalation injury remains unclear. Studies have revealed that astragaloside-IV (AS-IV), a natural compound extracted from Astragalus membranaceus, has protective effects in inflammatory diseases. Here, we investigated whether the protective effects of AS-IV occur because of the suppression of heat-induced endoplasmic reticulum (ER) stress and excessive autophagy Methods: AS-IV was administered to Wistar rats after thermal inhalation injury and 16HBE140-cells were treated with AS-IV. TNF-, IL-6, and IL-8 levels were determined by ELISA and real-time PCR. ER stress and autophagy were determined by western blot. Autophagic flux was measured by recording the fluorescence emission of the fusion protein mRFP-GFP-LC3 by dynamic live-cell imaging.RESULTS: AS-IV had protective effects against heat-induced reactive oxygen species production and attenuated ER stress. AS IV alleviated heat-induced excessive autophagy in vitro and in vivo. Excessive autophagy was attenuated by the PERK inhibitor GSK2656157 and eIF2 siRNA, suggesting that heat stress-induced autophagy can activate the PERK-eIF2 pathway. Beclin 1 and Atg5 siRNAs inhibited the upregulation of the inflammatory cytokines TNF-, IL-6, and IL-8 after heat exposure.CONCLUSIONS: Thus, AS-IV may attenuate inflammatory responses by disrupting the crosstalk between autophagy and the PERK-eIF2 pathway and may be an ideal agent for treating inflammatory pulmonary diseases.

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10:50

The Power of Millet 3 Ways Natural Blaze

millet

By Heather CallaghanEditor

When people think of incorporating non-gluten grains into their diet, they might be quick to grab some quinoa. But dont forget about millet!

Oh, did you think it was just bird feed? Well, dont let the birds hog it all.

Its an inexpensive, nutritional powerhouse that is actually way more versatile than quinoa.

Millet is a small, almost perfectly round, yellow grain. It may have a slight nuttiness or porridge-like quality to it. It is loaded with B-vitamins that help with nails, hair, stress and liver function. It is also packed with minerals like calcium, iron, magnesium, and more. It also contains healthy fats. It warms up my hands and feet which tells me it helps my metabolism. Its the good kind of carb that can support your thyroid, unlike harmful refined flour products.

Millet is more versatile than quinoa, in my opinion, because it makes for a better sweet meal if you choose. I never thought quinoa could pull it off much more of a savory grain, if you ask me.

Millet can be mad...

10:40

Student-Made Tiny House Represents New American Dream Natural Blaze

 

College students created this beautiful tiny home.

Every year, students from California State University, Sacramentos STORC school get to work on projects that pave a way to a more sustainable and technological future. Most years, students working in the the Sustainable Technology Optimization Research Center (STORC) build a tiny house from scratch, which is an incredible feat. Even more impressive is their commitment to create the house with the latest technologies to make sure that the structure uses as little energy as possible.

This year, students from STORC built a beautiful tiny house that includes solar panels to power the electricity as well as a solar-powered water heater to heat the 20-gallon water tank.

The 400-square-foot house, which has wheels affixed to it for mobile functioning, allows dwellers to live as off-the-grid as possible as they embark on their self-selected journey. The solar panels can be seen on the roof as well as on one side of the structure so that ample electricity is generated.

...

10:35

Astragaloside IV inhibits progression of glioma cancer cells. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2017 Sep 9 ;491(1):98-103. Epub 2017 Jul 11. PMID: 28709870 Abstract Title:  Astragaloside IV inhibits progression of glioma via blocking MAPK/ERK signaling pathway. Abstract:  Glioma is one of the most common primary brain tumors in adults with a high mortality rate and relapse rate. Thus, finding better effective approaches to treat glioma has become very urgent. Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain cancers. However, its role in glioma remains unclear. Here, we studied the effects of AS-IV on glioma in vitro and in vivo, and explored the underlying mechanisms. Our results revealed that AS-IV dose-dependently inhibited the proliferation of U251 cells in vitro and attenuated tumor growth in vivo. In addition, the migration and invasion ability of U251 cell has been suppressed in presence of AS-IV. The levels of proliferating cell nuclear antigen (PCNA), Ki67, matrix metallopeptidase (MMP) -2, MMP-9 and vascular endothelial growth factor (VEGF) were decreased significantly by the treatment of different concentrations AS-IV. Furthermore, AS-IV also significantly weakened the activation of Mitogen-activated protein kinase/Extracellular regulated protein kinase (MAPK/ERK) signaling pathway in vitro and in vivo. Taken together our study has identified a novel function of AS-IV and provided a molecular basis for AS-IV potential applications in the treatment of glioma and other cancers.

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10:24

The theory is presented that migraines are an integrated defensive, neuroprotective response to brain oxidative stress. GreenMedInfo

PMID:  Headache. 2017 Oct 16. Epub 2017 Oct 16. PMID: 29034461 Abstract Title:  The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory. Abstract:  BACKGROUND: Previous research has suggested that migraineurs show higher levels of oxidative stress (lipid peroxides) between migraine attacks and that migraine triggers may further increase brain oxidative stress. Oxidative stress is transduced into a neural signal by the TRPA1 ion channel on meningeal pain receptors, eliciting neurogenic inflammation, a key event in migraine. Thus, migraines may be a response to brain oxidative stress.RESULTS: In this article, a number of migraine components are considered: cortical spreading depression, platelet activation, plasma protein extravasation, endothelial nitric oxide synthesis, and the release of serotonin, substance P, calcitonin gene-related peptide, and brain-derived neurotrophic factor. Evidence is presented from in vitro research and animal and human studies of ischemia suggesting that each component has neuroprotective functions, decreasing oxidant production, upregulating antioxidant enzymes, stimulating neurogenesis, preventing apoptosis, facilitating mitochondrial biogenesis, and/or releasing growth factors in the brain. Feedback loops between these components are described. Limitations and challenges to the model are discussed.CONCLUSIONS: The theory is presented that migraines are an integrated defensive, neuroprotective response to brain oxidative stress.

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10:17

These results indicated that astragaloside reversed the drug resistance of 5 fluorouracil resistant Bel 7402/FU cells. GreenMedInfo

PMID:  Mol Med Rep. 2017 Sep ;16(3):2761-2766. Epub 2017 Jul 5. PMID: 28713943 Abstract Title:  Astragaloside IV downregulates the expression of MDR1 in Bel7402/FU human hepatic cancer cells by inhibiting the JNK/cJun/AP1 signaling pathway. Abstract:  Previous studies demonstrated that astragaloside IV (ASIV) is a potential Pglycoprotein (Pgp)mediated multidrug resistance (MDR) reversal agent through mechanisms involving downregulation of the gene expression of mdr1. In order to investigate whether the cJun Nterminal kinase (JNK) signaling pathway is involved in the mechanism underlying ASIVinduced downregulated the expression of mdr1, the present study used 5fluorouracilresistant Bel7402/FU human hepatic cancer cells as target cells. ASIV (0.1 mM) decreased the protein expression of phosphorylated (p)JNK and pcJun in the Bel7402/FU cells, as determined using western blot analysis. Treatment with the JNK pathway inhibitor, SP600125, at a concentration of 11 M, decreased the mRNA expression levels of mdr1 and Pgp, as determined using reverse transcriptionquantitative polymerase chain reaction and western blot analyses, and similar effects were observed following exposure to ASIV. Furthermore, electrophoretic mobility shift assays demonstrated that the DNAbinding activity of activator protein1 (AP1) was decreased by 0.1 mM ASIV or 11 M SP600125. Flow cytometric analysis revealed that 0.1 mM ASIV or 11 M SP600125 increased the intracellularaccumulation of fluorescent Pgp substrates, including rhodamine 123. Taken together, these results indicated that ASIV reversed the drug resistance of Bel7402/FU cells by downregulating the expression of mdr1 via inhibition of the JNK/cJun/AP1 signaling pathway.

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10:01

Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation. GreenMedInfo

PMID:  Mol Med Rep. 2017 Sep ;16(3):3269-3275. Epub 2017 Jul 14. PMID: 28714008 Abstract Title:  Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation. Abstract:  Increased cell apoptosis in chondrocytes is a feature of degenerative cartilage. Astragaloside IV (AST) has been proven to possess an antiarthritic effect by preventing interleukin (IL)1induced cartilage damage. However, the role of AST on chondrocyte apoptosis and its underlying mechanism remains unknown. In the present study, degenerative chondrocytes isolated from patients with osteoarthritis (OA) were subjected to AST and IL1 treatment. Results indicated that ASTprotected against chondrocyte apoptosis induced by IL1. Western blotting indicated that AST increased the protein expression of LC3II/I and decreased P62/SQSTM1 expression, which suggested that AST upregulated autophagy activity in chondrocytes. Fluorescent protein GFPLC3 analysis and transmission electron microscopy observation confirmed that autophagy was promoted by AST. In contrast, after autophagy inhibited by 3methyladenine, chondrocyte apoptosis was further increased under IL1 treatment. Ultimately, rapamycin was used as a positive control, whose results confirmed that rapamycinmediated autophagy also decreased chondrocyte apoptosis induced by IL1. In conclusion, these results suggested that ASTmediated autophagy serves an antiapoptotic role in chondrocytes, which may aid the development of novel therapeutic approaches for OA treatment.

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09:55

Astragaloside attenuated cisplatin-mediated renal injury. GreenMedInfo

PMID:  Free Radic Res. 2017 Jul-Aug;51(7-8):669-683. Epub 2017 Aug 11. PMID: 28750561 Abstract Title:  Renoprotective mechanisms of Astragaloside IV in cisplatin-induced acute kidney injury. Abstract:  Nephrotoxicity remains a serious adverse effect of cisplatin chemotherapy, limiting its clinical usage. Numerous studies show that oxidative stress and inflammation are closely associated with cisplatin-induced renal damage. Astragaloside IV (AS-IV) has been found to possess antioxidant and anti-inflammation functions. Therefore, we investigated the potential curative effects of AS-IV against cisplatin-induced renal injury and the possible cellular mechanism for activity, both in vitro and in vivo. We found that pretreatment of HK-2 cells with AS-IV could mitigate cisplatin-induced cell damage caused by oxygen-free radicals and the inflammatory response, as evidenced by reduced formation of reactive oxygen species (ROS) and inflammatory cytokines. AS-IV improved cisplatin-induced renal dysfunction and histopathological injury in mice. Additionally, AS-IV enhanced the activities of total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and catalase (CAT). It also inhibited cisplatin-induced overproduction of kidney injury molecule-1 (KIM-1), malondialdehyde (MDA), tumour necrosis factor- (TNF-), and interleukin-1 (IL-1) in kidney tissues. We found that the protective effects of AS-IV occurred via activation of the nuclear factor-erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins and inhibition of nuclear factor-appaB (NF-B) activation. Further, small interfering RNA (siRNA) knockdown of Nrf2 abrogated the protective effects of AS-IV against cisplatin-induced oxidative stress and blocked the inhibitory effects of AS-IV on cisplatin-induced NF-B activation and inflammatory cytokine production. In conclusion, our data suggested that AS-IV attenuated cisplatin-mediated renal injury, and these protective effects might be due to inhibition of both oxidative damage and inflammatory response via activation of Nrf2 system and suppression of NF-B activation.

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09:47

Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. GreenMedInfo

PMID:  PLoS One. 2017 ;12(8):e0182558. Epub 2017 Aug 2. PMID: 28767702 Abstract Title:  Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. Abstract:  The aim of this study was to investigate the effect and possible mechanism of Astragaloside IV (AS-IV) on retarding the progression of diabetic nephropathy (DN) in a type 2 diabetic animal model, db/db mice. Eight-week-old male db/db diabetic mice and their nondiabetic littermate control db/m mice were used in the present study. AS-IV was administered to the db/db mice by adding it to standard feed at a dose of 1g/kg for 12 weeks. Renal injury was assessed by urinary albumin excretion (UAE) and Periodic acid-Schiff staining. The protein expression levels of mitochondrial quality-control-associated proteins were evaluated using Western blotting and immunohistochemical staining analysis. At the end of the experiment, db/db mice showed overt renal injury, as evidenced by increased UAE, increased urinary N-acetyl--D-glucosaminidase (NAG), expansion of mesangial matrix, and increased renal tubular area. AS-IV administration significantly reduced UAE and urinary NAG and ameliorated the renal pathologic injury seen in db/db mice. Furthermore, the expression of dynamin-related protein 1 (Drp-1), mitochondrialfission protein 1 (Fis-1), and mitochondrial fission factor (MFF), the main regulators of mitochondrial fission, was significantly increased in db/db mice. Moreover, PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy was abnormally activated in db/db mice. AS-IV significantly reduced renal Drp-1, Fis-1, and MFF expression and downregulated PINK1/Parkin-mediated mitophagy in db/db mice. However, mitochondrial biogenesis and mitochondrial fusion-associated protein levels were not significantly different between db/m and db/db mice in our study, with or without AS-IV treatment. In conclusion, administration of AS-IV could retard DN progression in type 2 diabetes mice, which might be associated with restoration of the mitochondrial quality control network.

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09:38

Astragaloside IV improves bleomycin-induced pulmonary fibrosis. GreenMedInfo

PMID:  Front Pharmacol. 2017 ;8:513. Epub 2017 Aug 8. PMID: 28848434 Abstract Title:  Astragaloside IV Improves Bleomycin-Induced Pulmonary Fibrosis in Rats by Attenuating Extracellular Matrix Deposition. Abstract:  Pulmonary fibrosis is a devastating lung disorder with mysterious pathogenesis and limited treatment options. It is well-recognized that the uncontrolled proliferation of lung fibroblasts and differentiation of fibroblasts into myofibroblasts excessively produce extracellular matrix (ECM) proteins which contribute to the fibrosis change of the lungs. Thus, blocking ECM accumulation would delay fibrosis progression. In this study, we observed the effects of astragaloside IV (ASV) (10 mg/kg/d) on ECM proteins in bleomycin (BLM, 5 mg/kg)-treated rats. Our results showed that ASV not only ameliorated BLM-induced body weight loss, lung coefficient increase, histological changes and collagen secretion, but also reduced the levels of type III collagen (Col-III) in lung homogenate, laminin (LN) and hyaluronic acid (HA) in serum, as well as hydroxyproline (HYP) in lung tissue. Besides, ASV significantly down-regulated the levels of high-mobility group box1 (HMGB1) in serum and lung tissue, and inhibited the up-regulated expression of-SMA (marker of myofibroblasts) in the lungs. Taken together, these findings indicate that ASV attenuates BLM-induced ECM deposition, supporting its use as a promising candidate to treat lung fibrosis.

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09:19

Teen Girl Dies In Sleep After HPV Vaccine Vaxxter

Jasmin Soriat, 19, began showing evidence of neurological disorder shortly after receiving a shot of Gardasil. It was her second round of the vaccine. Weeks later, Soriat died in her sleep. The student from Vienna...

The post Teen Girl Dies In Sleep After HPV Vaccine appeared first on Vaxxter.

09:19

Administration of astragaloside containing fluid led to a dramatic improvement in survival following crush syndrome. GreenMedInfo

PMID:  Ann Intensive Care. 2017 Sep 4 ;7(1):90. Epub 2017 Sep 4. PMID: 28871521 Abstract Title:  Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats. Abstract:  BACKGROUND: Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop cardiac failure, kidney dysfunction, and systemic inflammation, even when fluid therapy is administered. We evaluated whether the administration of astragaloside-IV (AS)-containing fluid improved survival by preventing kidney and muscular mitochondrial dysfunction in a rat model of CS.RESULTS: The CS model was generated by subjecting anesthetized rats to bilateral hind limb compression with a rubber tourniquet for 5 h. Rats were then randomly divided into four groups: (1) sham; (2) CS with no treatment; (3) CS with normal saline treatment; and (4) CS with normal saline + 10 mg/kg AS. AS-containing fluid improved kidney function by improving shock and metabolic acidosis in CS rats. In addition, there was areduction in oxidative damage. The attenuation of hyperkalemia was significantly related to improving muscle injury via preventing mitochondrial dysfunction. Moreover, this mitochondria protection mechanism was related to the nitric oxide (NO) generated by activation of endothelial nitric oxide synthase, which provided an anti-oxidative and anti-inflammatory effect.CONCLUSIONS: Treatment with AS-containing fluid led to a dramatic improvement in survival following CS because of direct and indirect anti-oxidative effects in the kidney, and improvements in mitochondrial dysfunction and inflammation owing to AS acting as an NO donor in injured muscle.

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08:49

Astragaloside suppressed gastric inflammation caused by alcohol. GreenMedInfo

PMID:  Int Immunopharmacol. 2017 Nov ;52:211-217. Epub 2017 Sep 21. PMID: 28942222 Abstract Title:  The effect of Astragaloside IV on ethanol-induced gastric mucosal injury in rats: Involvement of inflammation. Abstract:  The present study aimed to investigate the potential protective effects of Astragaloside IV (AS-IV) against ethanol-induced gastric mucosal injury in rats. The animals were divided into 7 groups and pretreated with vehicle, various doses of AS-IV (1,2 and 4mg/kg, i.p.) or omeprazole (40mg/kg), 75min later, the gastric mucosal injury was induced by oral administration of ethanol. One hour after ethanol ingestion, the rats were euthanized and gastric tissues were collected to biochemical analyze. Myeloperoxidase (MPO), tumor necrosis factor (TNF-), interleukin 1 (IL-1), interleukin 10 (IL-10), nuclear factor kappa B (NF-B) p65 protein, TNF receptor-associated factor 2 (TRAF2) and nuclear NF-B (nNF-B) proteins were estimated by enzyme-linked immunosorbent assay or western blot analysis. The gastric mucosal lesions were assessed by macroscopic and histopathological examinations. The results showed pretreatment with AS-IV attenuated the severity of ethanol gastric mucosal damage as evidenced by lowering of injury scores, histopathologic aberrations and leukocyte invasion. These actions were analogous to the referenceomeprazole. AS-IV suppressed gastric inflammation by curbing of MPO, TNF- levels along with NF-B p65 and TRAF2 expression. It also augmented the anti-inflammatory IL-10 levels. Meanwhile, AS-IV could inhibit NF-B transcription by inhibiting the expression of NF-B p65 and increasing the expression of nNF-B. It seems that AS-IV as an anti-inflammatory agent may have a protective effect against ethanol-induced mucosal injury by inhibition of neutrophil infiltration and reducing the expression of NF-B p65, TRAF2 and inflammatory cytokines via regulating TNF-/NF-B signal pathway ingastric tissue.

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08:41

Astragaloside II promotes intestinal epithelial repair. GreenMedInfo

PMID:  Sci Rep. 2017 Sep 26 ;7(1):12302. Epub 2017 Sep 26. PMID: 28951595 Abstract Title:  Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway. Abstract:  Astragaloside II (AS II) extracted from Astragalus membranaceus has been reported to promote tissue wound repair. However, the effect of AS II on inflammatory bowel disease is unknown. We investigated the effects and mechanism of AS II on intestinal wound healing in both in vitro and in vivo models. Human intestinal Caco-2 cells were treated with multiple concentrations of AS II to assess cell proliferation, scratch wound closure, L-arginine uptake, cationic amino acid transporter activity, and activation of the mTOR signaling pathway. These effects were also measured in a mouse model of colitis. AS II promoted wound closure and increased cell proliferation, L-arginine uptake, CAT1 and CAT2 protein levels, total protein synthesis, and phosphorylation of mTOR, S6K, and 4E-BP1 in Caco-2 cells. These effects were suppressed by lysine or rapamycin treatment, suggesting that the enhanced arginine uptake mediates AS II-induced wound healing. Similar results were also observed in vivo. Our findings indicate that AS II can contribute to epithelial barrier repair following intestinal injury, and may offer a therapeutic avenue in treating irritable bowel disease.

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08:27

Astragaloside may serve as an effective therapeutic agent for aging and Parkinson's disease. GreenMedInfo

PMID:  Exp Ther Med. 2017 Sep ;14(3):2650-2656. Epub 2017 Jul 25. PMID: 28962208 Abstract Title:  Astragaloside IV rescues MPP(+)-induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A. Abstract:  Methionine sulfoxide reductase (Msr) repairs oxidatively damaged proteins through acting as an antioxidant. Oxidative stress has been postulated to cause the mitochondrial dysfunction that is associated with aging and certain diseases, including Parkinson's disease (PD). The present study investigated the protective effects of astragaloside IV (AS-IV) on 1-methyl-4-phenylpyridinium (MPP(+))-induced mitochondrial dysfunction through MsrA in PC12 cells. This revealed that oxidative stress reduced the expression of MsrA following MPP(+) treatment. AS-IV was demonstrated to protect PC12 cells from MPP(+)-induced oxidative damage through upregulating MsrA. MsrA expression was dependent on the Sirt1-FOXO3a signaling pathway. In addition, knockdown of MsrA reduced the protective effects of AS-IV, indicating that the antioxidant effects of AS-UV occurred through MsrA. These results suggest that AS-IV exerts antioxidant effects and regulates mitochondrial function. Thus, AS-IV may serve as an effective therapeutic agent for aging and PD.

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08:04

This Is How Colorado Is Using Medical Marijuana to Fight the Opioid Crisis Healthy Holistic Living

This article is shared with permission from our friends at Dr. Mercola.  Cannabis is a vastly underutilized therapeutic option that has been wrongly vilified by U.S. regulatory agencies. In this interview, Dr. Margaret Gedde, a Stanford-trained pathologist and award-winning researcher, discusses the therapeutic value of this plant. While initially focused...

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08:00

Double Dark Chocolate Brownies with High Fiber, Healthy Fat, and Zero Gluten Healthy Holistic Living

This article is shared with permission from our friends, Jenni + Mimi, Registered Holistic and founders of The Naughty Nutritionists! Download your FREE copy of the Metabolism Reset Guide for 10 easy steps to reset your body for optimal energy, sustained weight loss and an amazing summer season! Download here!...

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07:58

Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells. GreenMedInfo

PMID:  Int J Mol Med. 2017 Sep 27. Epub 2017 Sep 27. PMID: 29039448 Abstract Title:  Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells by inhibiting-synuclein expression via the p38 MAPK pathway. Abstract:  An oxidative stress insult is one of the principal causes of Parkinson's disease. Astragaloside IV (AS-IV), a constituent extracted from Astragalus membranaceus, has been demonstrated to exert antioxidant effects. However, the mechanisms responsible for the antioxidant properties and neuroprotective effects of AS-IV remain unclear. In this study, we examined the protective effects of AS-IVagainst the apoptosis of human neuronal cells (SH-SY5Y cells) induced by hydrogen peroxide (H2O2). The results revealed that AS-IV pre-treatment attenuated the H2O2induced loss of SH-SY5Y cells in a dose-dependent manner; AS-IV exerted significant protecitve effects by decreasing the apoptoticratio and attenuating reactive oxygen species overproduction in H2O2-exposed SH-SY5Y cells. By means of immunofluorescence staining, AS-IV was found to decrease the expression of -synuclein and to increase the expression of tyrosine hydroxylase (TH) in the cells, which had been increased and decreased, respectively by H2O2. As shown by western blot analysis, the protective effects of AS-IV against SH-SY5Y cell injury induced by H2O2 were also mediated via the downregulation of the ratio of Bax/Bcl-2. We found that the neuroprotective effects of AS-IV were associated with the inhibition ofthe expression of the -synuclein via the p38 mitogen-activated protein kinase (MAPK) signalling pathway. On the whole, our results suggest that AS-IV exerts protective effects against neurodegenerative diseases by targeting -synuclein or TH.

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07:56

Anti-Inflammatory Sweet Potato Chili with Black Beans, Cumin, and More Healthy Holistic Living

This article is shared with permission from our friends, Jenni + Mimi, Registered Holistic and founders of The Naughty Nutritionists! Download your FREE copy of the Metabolism Reset Guide for 10 easy steps to reset your body for optimal energy, sustained weight loss and an amazing summer season! Download here! Chili...

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The post Anti-Inflammatory Sweet Potato Chili with Black Beans, Cumin, and More appeared first on Healthy Holistic Living.

07:53

Better Than Reeses: How To Make Chocolate Nut Butter Cups Without Toxic Additives Healthy Holistic Living

This article is shared with permission from our friends, Jenni + Mimi, Registered Holistic Nutritionists and founders of at  The Naughty Nutritionists. Download your FREE copy of the Metabolism Reset Guide for 10 easy steps to reset your body for optimal energy, sustained weight loss and an amazing summer season! Download here! This...

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The post Better Than Reeses: How To Make Chocolate Nut Butter Cups Without Toxic Additives appeared first on Healthy Holistic Living.

07:46

Astragaloside significantly inhibited colorectal cancer cell migration and invasion by inducing miR-134 expression. GreenMedInfo

PMID:  Cell Physiol Biochem. 2017 Oct 17 ;43(4):1. Epub 2017 Oct 17. PMID: 29041002 Abstract Title:  Astragaloside IV Induced miR-134 Expression Reduces EMT and Increases Chemotherapeutic Sensitivity by Suppressing CREB1 Signaling in Colorectal Cancer Cell Line SW-480. Abstract:  BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Although chemotherapy is the primary means in colorectal cancer treatment, it is burdenerd by adverse drug effects. Drug-resistance is one of the most important challenges for chemotherapy and epithelial-mesenchymal transition (EMT) plays critical role in the development of drug resistance.AIMS: The aim of this study was to investigate the mechanisms underlying the effect of astragaloside IV (AS-IV) on miR-134 expression, EMT and chemotherapeutic sensitivity in CRC.METHODS: Cell proliferation, transfection assay, western blot, real-time PCR, cell migration and invasion assay and luciferase reporter assay were used to detect the effects of AS-IV on CRC.RESULTS: AS-IV significantly inhibited CRC cell migration and invasion by inducing miR-134 expression. Moreover, AS-IV and miR-134 increased the sensitivity of CRC tumors to oxaliplatin (OXA) chemotherapy. cAMP responsive element-binding protein 1 (CREB1), which was required for CRC cells migration, invasion and drug sensitivity, was significantly down-regulated by AS-IV.CONCLUSIONS: Our results indicated that AS-IV inhibited CRC EMT by inducing miR-134 expression which significantly down-regulated the CREB1 signaling pathway, and therefore increased the sensitivity to chemotherapy. Our findings provided new insight into the mechanisms of chemotherapy-resistant CRC, and may open new therapeutic options in the treatment of this devastating disease.

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07:07

These findings suggest that astaxanthin offers neuroprotection against doxorubicin induced cognitive impairment. GreenMedInfo

PMID:  Mol Neurobiol. 2017 Oct 16. Epub 2017 Oct 16. PMID: 29039023 Abstract Title:  Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries. Abstract:  Chemobrain refers to a common sequelae experienced by 15-80% of cancer patients exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been implicated in a strenuous neurotoxicity manifested as decline in cognitive functions, most probably via cytokine-induced oxidative and nitrosative damage to brain tissues. Astaxanthin (AST), a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti-inflammatory, and antiapoptotic activities. Therefore, the aim of the current study was to investigate the potential neuroprotective and memory-enhancing effects of AST against DOX-induced behavioral and neurobiological abnormalities. Briefly, AST treatment (25 mg/kg) significantly protected against DOX-induced memory impairment. Furthermore, AST restored hippocampal histopathological architecture, halted DOX-induced oxidative and inflammatory insults, mitigated the increase in acetylcholinesterase activity, and consistently downregulated the overactiveapoptotic machineries. In conclusion, these findings suggest that AST offers neuroprotection against DOX-induced cognitive impairment which could be explained at least partly by its antioxidant, anti-inflammatory, and antiapoptotic effects.

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06:58

Old Tattoos Causes Illness for Woman 15 Years After She Got It Healthy Holistic Living

In todays day and age, its rare to meet someone who doesnt have a tattoo. In the past tattoos were seen as taboo, making it difficult for people to get a decent job. That mindset has radically shifted in recent years, and now its not only rebellious youngsters that are...

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The post Old Tattoos Causes Illness for Woman 15 Years After She Got It appeared first on Healthy Holistic Living.

06:54

19-Year-Old Boy Went from Being Obese to a Personal Trainer, This Is How He Did It Healthy Holistic Living

If you have a lot of weight to lose, it can feel intimidating to work with a personal trainer who does not understand your emotional and personal experience. Luckily for you, 21-year-old Peter Nielsen of Denmark is one personal trainer who can and will understand your struggle. After all, he...

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The post 19-Year-Old Boy Went from Being Obese to a Personal Trainer, This Is How He Did It appeared first on Healthy Holistic Living.

06:32

Astaxanthin may reduce alveolar bone loss by increasing osteoblastic activity and decrease osteoclastic activity in experimental periodontitis model. GreenMedInfo

PMID:  J Periodontal Res. 2017 Oct 17. Epub 2017 Oct 17. PMID: 29044575 Abstract Title:  Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis. Abstract:  BACKGROUND AND OBJECTIVE: Astaxanthin is a keto-carotenoid that has a strong antioxidant effect. The purpose of this study was to evaluate the effects of astaxanthin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats.MATERIAL AND METHODS: Wistar rats were divided into four experimental groups: non-ligated (C, n = 6); ligature only (L, n = 6); ligature and astaxanthin (1 mg/kg/day astaxanthin, AS1 group, n = 8); ligature and astaxanthin (5 mg/kg/day astaxanthin, AS5 group, n = 8). Silk ligatures were placed at the gingival margin of lower first molars of the mandibular quadrant. The study duration was 11 days and the animals were killed at the end of this period. Changes in alveolar bone levels were clinically measured and tissues were immunohistochemically examined, osteocalcin, bone morphogenic protein-2, inducible nitric oxide synthase, Bax and bcl-2 levels in alveolar bone and tartrate-resistant acid phosphatase-positive osteoclast cells, osteoblast and inflammatory cell counts were determined.RESULTS: Alveolar bone loss was highest in the L group and the differences among the L, AS1 and AS5 groups were also significant (P 

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06:29

Top 6 Ways to Heal Thyroid Disease new research findings two

Top 6 Ways to Heal Thyroid Disease

Posted on: Thursday, October 19th 2017 at 7:30 am

Discover protocols that could lead you into thyroid disease remission.
I didnt always want to be a thyroid pharmacist!  In fact, I didnt have much interest in the thyroid until my own thyroid diagnosis in 2009. This diagnosis came after almost a decade of some pretty life-altering symptoms. I was so fatigued I had to sleep for 12 hours each night just to feel human. My sharp mind that kept me on the honor roll during my doctorate program studies was not so sharp anymore! I began to have brain fog and started being forgetful and then there was the intense anxiety
I remember levels of anxiety so bizarre that my husband couldnt go for a jog without me thinking hed been hit by a car or left with some woman!
I was in pain pretty much everyday, and I ended up being diagnosed with carpal tunnel in both arms. I wore braces on my arms and eventually had to resign from my job because it involved too much computer time. I had irritable bowel syndrome and acid reflux and went to so many doctors, I felt like I had more doctors visits than visits with friends!
Some doctors told me that there was nothing wrong with me, other doctors said it was all in my head and suggested antidepressants, other doctors told me that everyone was tired and stressed. One of the most amusing answers I got from a health care professional was Youre just getting older.
Did I mention that I was only 25 years old at the time?
When I first got my diagnosis, I finally felt validated, but sadly, the doctors still didnt have many solutions for me. I was prescribed synthetic thyroid hormone (Synthroid, the #1 selling drug in the US in 2 of the last three years).
...

06:22

Cryptoxanthin treatment exhibits greater cardioprotective efficacy against I/R injury than astaxanthin and vitamin E. GreenMedInfo

PMID:  Mol Nutr Food Res. 2017 Oct ;61(10). Epub 2017 Jul 18. PMID: 28544535 Abstract Title:  -Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice. Abstract:  SCOPE: -Cryptoxanthin and astaxanthin are antioxidant carotenoid pigments that inhibit lipid peroxidation as potently as vitamin E. We hypothesized that acute treatment with -cryptoxanthin and astaxanthin causes similar reductions in the sizes of cardiac infarcts caused by ischemia-reperfusion (I/R) injury by attenuating oxidative stress and cardiac mitochondrial dysfunction.METHODS AND RESULTS: C57BL/6 mice (n = 36) were randomized to receive vehicle, -cryptoxanthin, astaxanthin, or vitamin E at 50 mg/kg by gavage feeding prior to I/R injury. Cardiac I/R was induced by left anterior descending coronary artery ligation followed by reperfusion. All treatments significantly reduced infarct sizes by 36-57%, attenuated apoptosis and also attenuated cardiac mitochondrial dysfunction in the treated groups compared to the control group. Although astaxanthin and vitamin E exhibited similar efficacy with respect to cardioprotection, -cryptoxanthin exhibited greater efficacy than its counterparts, as itreduced infarct sizes by 60%. -Cryptoxanthin was more effective than astaxanthin and vitamin E because it reduced cardiac mitochondrial swelling, mitochondrial depolarization, the Bax/Bcl-2 ratio, and plasma and cardiac thiobarbituric acid reactive substances levels more significantly than its counterparts.CONCLUSION: Acute-cryptoxanthin treatment exhibits greater cardioprotective efficacy against I/R injury than astaxanthin and vitamin E by reducing infarct sizes and attenuating apoptosis, oxidative stress, and mitochondrial dysfunction.

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05:54

Supplementation of -cryptoxanthin would be beneficial for the maintenance of joint health and as prophylaxis against osteoarthritis. GreenMedInfo

PMID:  Biol Pharm Bull. 2017 ;40(7):1116-1120. PMID: 28674255 Abstract Title:  Amelioration of the Development of Osteoarthritis by Daily Intake of-Cryptoxanthin. Abstract:  -Cryptoxanthin, which is primarily obtained from citrus fruits such as Satsuma mandarins, is a major carotenoid routinely found in human serum. Recently, we demonstrated that daily oral intake of -cryptoxanthin prevented ovariectomy-induced bone loss and ameliorated neuropathic pain in mice. Although -cryptoxanthin exerts preventive effects on various lifestyle-related diseases, there have been no studies on the effect of -cryptoxanthin on the development of osteoarthritis, the most common degenerative joint disease, which frequently leads to loss of ability and stiffness in the elderly. Here we showed that daily oral administration of -cryptoxanthin significantly prevented the development of osteoarthritis developed by surgically inducing knee joint instability in mice in vivo. Furthermore, in vitro experiments revealed that -cryptoxanthin markedly inhibited the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix in primary chondrocytes. Our results suggest that oral supplementation of -cryptoxanthin would be beneficial for the maintenance of joint health and as prophylaxis against osteoarthritis.

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05:45

-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-B and Nrf2 pathways in insulin resistance induced by high-fat diet. GreenMedInfo

PMID:  Food Chem Toxicol. 2017 Sep ;107(Pt A):270-279. Epub 2017 Jul 6. PMID: 28689061 Abstract Title:  -Cryptoxanthin ameliorates metabolic risk factors by regulating NF-B and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents. Abstract:  The aim of this experiment was to determine the effects of-cryptoxanthin (BCX) on the cardiometabolic health risk factors and NF-B and Nrf2 pathway in insulin resistance induced by high-fat diet (HFD) in rodents. Twenty-eight Sprague-Dawley rats were allocated into four groups: (1) Control, rats fed a standard diet for 12 weeks; (2) BCX, rats fed a standard diet and supplemented with BCX (2.5 mg/kg BW) for 12 weeks; (3) HFD, rats fed a HFD for 12 weeks, (4) HFD + BCX, rats fed a HFD and supplemented with BCX for 12 weeks. BCX reduced cardio-metabolic health markers and decreased inflammatory markers (P 

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05:30

Gardasil safety and efficacy debunking the HPV vaccine myths Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

There was an article published in Pediatrics that described how educating either teenagers or their parents about HPV vaccinations had little effect on the overall vaccination rate for the vaccine. Essentially, the researchers found that it was a 50:50 probability that any teen would get the vaccine, regardless of their knowledge of HPV and the vaccine itself.

Skeptical Raptor

05:29

It is hypothesized that baicalin exerts cardioprotective effects via suppression of the Wnt/ catenin signalling pathway. GreenMedInfo

PMID:  Mol Med Rep. 2017 Oct 10. Epub 2017 Oct 10. PMID: 29039516 Abstract Title:  Baicalin alleviates H2O2induced injury of H9c2 cardiomyocytes through suppression of the Wnt/catenin signaling pathway. Abstract:  Baicalin is one of the active ingredients extracted from the dry root of Scutellaria baicalensis Georgi, which has been reported to be effective in preventing myocardial ischemia reperfusion injury. However, the mechanisms underlying its cardioprotective activities remain to be elucidated. In the present study, H2O2treated cardiomyocyte H9c2 cell line served as an in vitro model of oxidationdamaged cardiomyocytes to evaluate the effects of baicalin on the cardiac injury, and to investigate the underlying molecular mechanism. The results of the TOPFlash/Renilla reporter gene assay indicated that baicalin significantly suppressed the activation of protooncogene Wnt1 (Wnt)/catenin in 293 cells, in a dose dependent manner. In addition, baicalin significantly inhibited H2O2induced loss of H9c2 cell viability in MTT assay. Furthermore, western blotting analysis demonstrated that baicalin markedly attenuated H2O2induced cell apoptosis, as demonstrated by the downregulation of cleaved caspase3 and the increase in the apoptosis regulator Bcl2 (Bcl2)/apoptosis regulator BAX (Bax) ratio following baicalin treatment in H2O2treated H9c2 cells. Furthermore, baicalin markedly decreased the expression of catenin and downstream Axin2and myc protooncogene protein in H2O2treated H9c2 cells. Knockdown of catenin expression inhibited H2O2induced cell apoptosis. Finally, LiCl (a catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of catenin, which was significantly neutralized by the treatment with baicalin. Taken together, it is hypothesized that baicalin exerts cardioprotective effects via suppression of the Wnt/catenin signaling pathway.

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05:19

Baicalin inhibits the metastasis of highly aggressive breast cancer cells. GreenMedInfo

PMID:  Oncol Rep. 2017 Sep 28. Epub 2017 Sep 28. PMID: 29039569 Abstract Title:  Baicalin inhibits the metastasis of highly aggressive breast cancer cells by reversing epithelial-to-mesenchymal transition by targeting-catenin signaling. Abstract:  Metastasis is the main cause of death in breast cancer patients, which is due partly to the lack of effective treatment. Baicalin, a flavonoid compound isolated from the roots of Scutellaria lateriflora Georgi (Huang Qin), has recently been confirmed as an effective agent for the treatment of a variety of cancers. Yet, the effects and underlying molecular mechanisms of baicalin in regards to the metastasis of breast cancer remain unclear. In the present study, we found that baicalin had the potential to suppress the migration and invasion of highly aggressive breast cancer cells in a dose-dependent manner but had no impact on the viability of these cancer cells. Additionally, baicalin reversed the epithelial-to-mesenchymal transition (EMT) process, as evaluated by EMT markers in breast cancer cell lines with a change from a mesenchymal feature to an epithelial type. At the same time, the expression of-catenin mRNA and protein was dose-dependently downregulated by baicalin in highly invasive breast cancer cell lines, and overexpression of -catenin by adenoviruses abolished these beneficial effects of baicalin in regards to the migration and invasion, and EMT of breast cancer cells. Furthermore, using a xenograft mouse model, baicalin markedly reduced liver and lung metastasis of breast cancer, inhibited expression of -catenin, and degraded the EMT molecules vimentin and Slug in the orthotopic tumor tissues. Taken together, all these results indicate that baicalin effectively suppresses the metastasis of breast cancer by reversing EMT, which may be mediated by downregulation of -catentin expression.

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05:16

European Lawmakers Want Glyphosate Weedkiller Banned in Europe by 2020 Health Impact News

European_Parliament_audience

Call comes within days of EU Parliamentary hearing on the Monsanto papers and glyphosates toxicity. Image source.

by GM Watch

Excerpts:

On 16 October a cross-party group of MEPs demanded a phase-out of glyphosate by December 2020. They want a ban on non-professional use of the herbicide and use in public parks or playgrounds after 15 December 2017, when the current authorisation expires. The MEPs want the Commission to withdraw its proposal for a 10-year renewal.

The MEPs also want a ban on agricultural application after 15 December 2017 in cases where integrated plant protection methods are sufficient. They are asking for Common Agricultural Policy (CAP) funds to be made available to farmers to support the transition to more sustainable methods of weed control.

In addition, the MEPs asked for a complete overhaul of the EUs risk assessment of pesticides. They want the REFIT reform of EU regulations to be used to ensure that the scientific evaluation of pesticides for regulatory approval is based only on published, peer-reviewed and independent studies commissioned by competent public authorities.

The MEPs demands appeared in a draft resolution that will be debated and voted on 19 October in the ENVI Committee.

These developments come ahead of the planned vote on the renewal of the authorisation for glyphosate in the Standing Committee (Plants, Animals, Food and Feed) on 23 October.

The MEPs draft resolution follows shortly after a joint ENVI/AGRI committee hearing in the European Parliament on the Monsanto papers and glyphosate, held on 11 October. You can watch videos of all the presentations here.

Read the full article at GM Watch....

05:10

Minnesota Somalis Have Worlds Highest Rate of Autism MMR Vaccine Link? Health Impact News

deaths_in_the_us_during_the_past_10_years_due_to_measles

Somali Parents Rational Concerns About Vaccine Safety

by Robert F. Kennedy, Jr.
World Mercury Project

A note from the World Mercury Project Team:

In June of this year, at the invitation of the Rochester Minnesota Post-Bulletin, World Mercury Project Chairman Robert F. Kennedy, Jr. submitted the following article for publication. The newspaper had invited Mr. Kennedy to submit an editorial after he complained about inaccuracies in the papers reports on the Somali measles outbreak.

While initially agreeing to publish the article, Post-Bulletin executive editor Jay Furst ultimately declined to run the piece. The paper made the decision in late September following almost four months of revisions, discussions and email exchanges with Mr. Kennedy. Furst explained that after five months of trying, the publication had been unable to find any public health official or pro-vaccine advocate willing to write a rebuttal or refute the facts outlined by Mr. Kennedy. Mr. Furst explained that Minnesota public health officials shown the article had made a generalized complaint that it was inaccurate, but that they refused to be specific about their claims or to provide citations. None of the many public health officials and vaccine advocates contacted by the newspaper were willing to go on record or to provide a rebuttal editorial. Nevertheless, Mr. Furst explained that because of the controversial nature of this issue, the editors felt that they could not run the article without a companion rebuttal piece.

Once again, public debate regarding the safety of the $46 billion vaccine industry has been muzzled. Mr. Kennedy says that Mr. Furst was genial, diligent, and professional in all their interactions, and genuinely apologetic about the outcome. According to a Minnesota Department of Health press release, the states measles outbreak was over by the end of August with 79 confirmed measles cases and no reported deaths or disabilities.


This winter, Minneapolis area health officials reported 76 measles cases among Somali-Americans. Mainstream media outle...

05:03

Baicalin has the potential to be used in novel anti cancer therapeutic formulations for treatment of ovarian cancer. GreenMedInfo

PMID:  Mol Med Rep. 2017 Oct 10. Epub 2017 Oct 10. PMID: 29039573 Abstract Title:  Antitumor effects of baicalin on ovarian cancer cells through induction of cell apoptosis and inhibition of cell migration in vitro. Abstract:  Baicalin, an active flavone isolated from Scutellaria baicalensis Georgi, has been demonstrated to induce various beneficial biochemical effects such as antiinflammatory, antiviral, and antitumor effects. However, the antitumor mechanism of baicalin is not well understood. In the present study, baicalin was demonstrated to inhibit the viabilityand migration of a widely used ovarian cancer cell line, A2780, in a dosedependent manner. MTT assays revealed that cell viability significantly decreased in ovarian cancer cells treated with baicalin compared with untreated cells, without effect on normal ovarian cells. Flow cytometric analysisindicated that baicalin suppressed cell proliferation by inducing apoptosis. The underlying mechanisms involved were indicated to be downregulation of the antiapoptotic protein Bcell lymphoma 2 apoptosis regulator and activation of caspase3 and 9. In addition, wound healing and transwell assays revealed that cell migratory potential and expression of matrix metallopeptidase (MMP)2 and MMP9 were significantly inhibited when cells were exposed to baicalin, compared with untreated cells. The present study therefore suggested that baicalin has the potential to be used in novel anticancer therapeutic formulations for treatment of ovarian cancer.

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04:56

Ginsenoside Rb1 and baicalin might promote the proliferation and differentiation of endogenous neural stem cells. GreenMedInfo

PMID:  Brain Res. 2017 Oct 13. Epub 2017 Oct 13. PMID: 29038007 Abstract Title:  Baicalin and ginsenoside Rb1 promote the proliferation and differentiation of neural stem cells in Alzheimer's disease model rats. Abstract:  BACKGROUND: This study aimed to explore the effect of ginsenoside Rb1 and baicalin on the proliferation and differentiation of neural stem cells (NSC) in Alzheimer's disease model rats.METHOD: The healthy Sprague Dawley male rats were randomly divided into 4 groups: control group, model group, ginsenoside Rb1 group and baicalin group. Besides, the animal model of dementia was induced by the injection of A1-40. 2 weeks later, the rats in the baicalin and ginsenoside Rb1 groups were injected with baicalin and ginsenoside Rb1, respectively. The contents, expression sites of Nestin, GFAP and NSE and the percentage of viable cells were detected by immunohistochemistry. In addition, the expression levels of Nestin, GFAP and NSE in hippocampus of rats were detected by western-blot and metrology analysis was performed using quantity.RESULTS: Injection of A1-40 significantly reduced the number of neuronal cells (p

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04:55

Minnesota Somalis Have Worlds Highest Rate of Autism MMR Vaccine Link? Vaccine Impact

deaths_in_the_us_during_the_past_10_years_due_to_measles

Somali Parents Rational Concerns About Vaccine Safety

by Robert F. Kennedy, Jr.
World Mercury Project

A note from the World Mercury Project Team:

In June of this year, at the invitation of the Rochester Minnesota Post-Bulletin, World Mercury Project Chairman Robert F. Kennedy, Jr. submitted the following article for publication. The newspaper had invited Mr. Kennedy to submit an editorial after he complained about inaccuracies in the papers reports on the Somali measles outbreak.

While initially agreeing to publish the article, Post-Bulletin executive editor Jay Furst ultimately declined to run the piece. The paper made the decision in late September following almost four months of revisions, discussions and email exchanges with Mr. Kennedy. Furst explained that after five months of trying, the publication had been unable to find any public health official or pro-vaccine advocate willing to write a rebuttal or refute the facts outlined by Mr. Kennedy. Mr. Furst explained that Minnesota public health officials shown the article had made a generalized complaint that it was inaccurate, but that they refused to be specific about their claims or to provide citations. None of the many public health officials and vaccine advocates contacted by the newspaper were willing to go on record or to provide a rebuttal editorial. Nevertheless, Mr. Furst explained that because of the controversial nature of this issue, the editors felt that they could not run the article without a companion rebuttal piece.

Once again, public debate regarding the safety of the $46 billion vaccine industry has been muzzled. Mr. Kennedy says that Mr. Furst was genial, diligent, and professional in all their interactions, and genuinely apologetic about the outcome. According to a Minnesota Department of Health press release, the states measles outbreak was over by the end of August with 79 confirmed measles cases and no reported deaths or disabilities.


This winter, Minneapolis area health officials reported 76 measles cases among Somali-Americans. Mainstream media outlets,...

03:22

Obesity-induced insulin resistance and lipotoxicity can be treated with ginsenoside Rg3. GreenMedInfo

PMID:  J Endocrinol. 2017 Dec ;235(3):223-235. PMID: 29042402 Abstract Title:  Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPAR. Abstract:  Healthy expansion of adipose tissue maintains metabolic homeostasis by storing excess chemical energy in increased fat mass. The STAT5-PPAR gamma pathway reportedly regulates adipocyte differentiation, lipid metabolism and adipogenesis. Ginsenoside Rg3 is one of the diverse groups of steroidal saponins, the major active components of ginseng, which have demonstrated pharmacological properties. In this study, we evaluated the therapeutic effects of ginsenoside Rg3 under pathological conditions in vitro and in vivo We examined the effects of ginsenoside Rg3 on glucose level, insulin sensitivity and lipogenesis in high-fat diet-fed C57BL/6 mice. Ginsenoside Rg3 was also applied to the pre-adipocyte cell line 3T3-L1 to assess the impact on lipogenesis. Ginsenoside Rg3 reduced epididymal white adipose tissue (eWAT) size and hepatic steatosis, and the amount of triglycerides (TGs) in both eWAT and liver. Similar to the murine model, Rg3-treated 3T3-L1 cells showed a reduction in lipid accumulation and amount of total TGs. Ginsenoside Rg3 regulates the expression of PPAR gamma though STAT5 in vitro and in vivo According to our results, lipid metabolism-related genes were downregulated in the high-fat mice and 3T3-L1 cell line. Rg3 shows potential for the amelioration of obesity-induced pathology, acting though STAT5-PPAR gamma to facilitate the healthy functioning of adipose tissue. This is the first report of evidence that obesity-induced insulin resistance and lipotoxicity can be treated with ginsenoside Rg3, which acts though the STAT5-PPAR gamma pathway in vivo and in vitro.

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03:14

Korean red ginseng extract was found capable of inducing angiogenesis both in vivo and in vitro models. GreenMedInfo

PMID:  J Ginseng Res. 2017 Oct ;41(4):477-486. Epub 2016 Sep 8. PMID: 29021694 Abstract Title:  Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor. Abstract:  BACKGROUND: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a differentpathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE).METHODS AND RESULTS: Combining in vitro and in vivo data, KGE at 500 g/mL was found to induce angiogenesis. According to the miRNA sequencing, 484 differentially expressed miRNAs were found to be affected by KGE. Among them, angiogenic-related miRNAs; miR-15b, -23a, -214, and -377 were suppressed by KGE. Meanwhile, their corresponding angiogenic proteins were stimulated, including vascular endothelial growth factor, vascular endothelial growth factor receptor-2, endothelial nitric oxide synthase, and MET transmembrane tyrosine kinase. The miRNAs-regulated signaling pathways of KGE were then found by Cignal 45-Pathway Reporter Array, proving that KGE could activate GR.CONCLUSION: KGE was found capable of inducing angiogenesis both in vivo and in vitro models through activating GR. This study provides a valuable insight into the angiogenic mechanisms depicted by KGE in relation to specific miRNAs.

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02:56

What You Need to Know About Gardasil The Driven Researcher

Gardasil, the HPV (Human Papillomavirus) vaccine on the Centers for Disease Control and Preventions (CDC) list of recommended inoculations for teenagers, has been the subject of debate worldwide since it was fast-tracked for approval in the US in 2006. The Merck-manufactured drug was developed to prevent infections caused by HPV, which is a group of 150 related viruses -- 15 of which are linked to cervical cancer. At the heart of the controversies are questions around the need for the vaccine, the efficacy of the vaccine and the fast-growing number of reports of severe reactions to the vaccine. The latter question has moved to the forefront of the debate as safety testing concerns have been raised and the number of vaccine-injured children has grown.

02:50

Ginsenoside Rg3-RGE could be potentially be used as an antiplatelet therapeutic agent against platelet-mediated cardiovascular disorders. GreenMedInfo

PMID:  J Ginseng Res. 2017 Oct ;41(4):548-555. Epub 2017 Jan 13. PMID: 29021703 Abstract Title:  Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation. Abstract:  BACKGROUND: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red ginseng extract (Rg3-RGE) to examine its role in platelet physiology.METHODS: To examine the effect of Rg3-RGE on platelet activation in vitro, platelet aggregation, granule secretion, intracellular calcium ([Ca(2+)]i) mobilization, flow cytometry, and immunoblot analysis were carried out using rat platelets. To examine the effect of Rg3-RGE on platelet activation in vivo, a collagen plus epinephrine-induced acute pulmonary thromboembolism mouse model was used.RESULTS: We found that Rg3-RGE significantly inhibited collagen-induced platelet aggregation and [Ca(2+)]i mobilization in a dose-dependent manner in addition to reducing ATP release from collagen-stimulated platelets. Furthermore, using immunoblot analysis, we found that Rg3-RGE markedly suppressed mitogen-activated protein kinase phosphorylation (i.e., extracellular stimuli-responsive kinase, Jun N-terminal kinase, p38) as well as the PI3K (phosphatidylinositol 3 kinase)/Akt pathway. Moreover, Rg3-RGE effectively reduced collagen plus epinephrine-induced mortality in mice.CONCLUSION: These data suggest that ginsenoside Rg3-RGE could be potentially be used as an antiplatelet therapeutic agent against platelet-mediated cardiovascular disorders.

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02:26

GALVANIC THERAPY LIFE IS AN ELECTRICAL PHENOMENON Lyra Nara Blog

We live in an electric world. The electricity courses invisibly in the darkness over great distances between stars, galaxies, planets, living bodies. We find electricity indispensable. Nature does the same since all matter and living beings are electrical. (Wallace Thornhill)   As we already know everything is made up of atoms, and atoms are made up

02:16

Global analysis of ginsenoside Rg1 protective effects in -amyloid-treated neuronal cells. GreenMedInfo

PMID:  J Ginseng Res. 2017 Oct ;41(4):566-571. Epub 2016 Dec 8. PMID: 29021705 Abstract Title:  Global analysis of ginsenoside Rg1 protective effects in-amyloid-treated neuronal cells. Abstract:  BACKGROUND: A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer's disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive.METHODS: To investigate the potential mechanisms of Rg1 in-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS.RESULTS: We identified a total of 1,149 proteins in three independent experiments. Forty-nine proteins were significantly altered by Rg1 after exposure of the cells to-amyloid peptides. The protein interaction network analysis showed that these altered proteins were clustered in ribosomal proteins, mitochondria, the actin cytoskeleton, and splicing proteins. Among these proteins, mitochondrial proteins containing HSD17B10, AARS2, TOMM40, VDAC1, COX5A, and NDUFA4 were associated with mitochondrial dysfunction in the pathogenesis of AD.CONCLUSION: Our results suggest that mitochondrial proteins may be related to the protective mechanisms of Rg1 in AD.

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02:00

After journal retracts their paper, authors post rebuttal on arXiv Retraction Watch

In July 2017, just days after accepting and publishing a paper, a physics journal discovered several scientific errors and decided to retract it. But the authorsAlexander Kholmetskii and Tolga Yarmanstrongly objected to the journals decision, so much so they published a detailed rebuttal to the retraction on the preprint server arXiv. The paper explores a []

The post After journal retracts their paper, authors post rebuttal on arXiv appeared first on Retraction Watch.

01:01

Somali Parents Rational Concerns About Vaccine Safety World Mercury Project

By Robert F. Kennedy, Jr.

A note from the World Mercury Project Team:

In June of this year, at the invitation of the Rochester Minnesota Post-Bulletin, World Mercury Project Chairman Robert F. Kennedy, Jr. submitted the following article for publication. The newspaper had invited Mr. Kennedy to submit an editorial after he complained about inaccuracies in the papers reports on the Somali measles outbreak.

While initially agreeing to publish the article, Post-Bulletin executive editor Jay Furst ultimately declined to run the piece. The paper made the decision in late September following almost four months of revisions, discussions and email exchanges with Mr. Kennedy. Furst explained that after five months of trying, the publication had been unable to find any public health official or pro-vaccine advocate willing to write a rebuttal or refute the facts outlined by Mr. Kennedy. Mr. Furst explained that Minnesota public health officials shown the article had made a generalized complaint that it was inaccurate, but that they refused to be specific about their claims or to provide citations. None of the many public health officials and vaccine advocates contacted by the newspaper were willing to go on record or to provide a rebuttal editorial. Nevertheless, Mr. Furst explained that because of the controversial nature of this issue, the editors felt that they could not run the article without a companion rebuttal piece.

Once again, public debate regarding the safety of the $46 billion vaccine industry has been muzzled. Mr. Kennedy says that Mr. Furst was genial, diligent, and professional in all their interactions, and genuinely apologetic about the outcome. According to a Minnesota Department of Health press release, the states measles outbreak was over by the end of August with 79 confirmed measles cases and no reported deaths or disabilities.


This winter, Minneapolis area health officials reported 76 measles cases among Somali-Americans. Mainstream media outlets, most recently, John Oliver in a 28 minute rant, vilified Somali-Americans for low vaccine rates and blamed Andrew Wakefield, MD and the so-called anti-vaccine movement for misleading Somalis about vaccine safety. Like most other journalists, Oliver never explained the story behind this story; the children of Minneapoliss Somalis suffer  the highest known rate of severe autism in the worldone in 32, according to University of Minnesota researchers.

Many Somalis believe that their childrens...

00:44

30 Worst Foods in America and Where Youll Find Them Healthy Holistic Living

This article is shared with permission from our friends at Food Matters. Todays food marketers have loaded many of their offerings with so much fat, sugar, and sodium that eating any of the foods in this article on a daily basis could destroy all your hard work and best intentions...

More

The post 30 Worst Foods in America and Where Youll Find Them appeared first on Healthy Holistic Living.

00:22

WATCH: Youll Be Shocked By What The Flu Shot Really Does To You Vaxxter

The flu shots effectiveness varies from year to year. But Dr. Suzanne Humphries explains what that shot is really doing to your immune health after you get it and if you get it every year....

The post WATCH: Youll Be Shocked By What The Flu Shot Really Does To You appeared first on Vaxxter.

00:13

California Gov Issues Vaccine State Of Emergency Vaxxter

California has a plethora of issues. There are fires raging in both the north and south regions. The state is near bankrupt. Homelessness and unemployment are at all-time highs. And now, they apparently have a...

The post California Gov Issues Vaccine State Of Emergency appeared first on Vaxxter.

00:13

MAWAs fluoride application may be submitted this week Fluoride Action Network

The flow of bureaucracy continues to trickle forward as the Meadville Area Water Authority inches closer to fluoridating the water it provides to consumers.

MAWA will soon complete its application to the state Department of Environmental Protection to install fluoridation equipment, consulting engineer Thomas Thompson told the authoritys board Wednesday.

I would anticipate that the fluoride application would be submitted this week, Thompson said.

DEP must review the application and issue a permit before the equipment can be installed. In addition to the construction permit, MAWA will also have to obtain an operations permit from DEP before fluoridation can begin, according to Melanie Williams, DEP community relations coordinator.

Review of permit applications like MAWAs typically takes 120 business days about seven months according to Williams.

*Original article online at http://www.meadvilletribune.com/news/local_news/mawa-s-fluoride-application-may-be-submitted-this-week/article_a3c834d3-4fae-5b74-9ba8-0443b555785d.html

00:06

Schizophrenia Genetic Research Running on Empty Mad In America

The May, 2017 edition of Scientific American featured an article on schizophrenia research by freelance journalist Michael Balter, entitled Schizophrenias Unyielding Mysteries.1 Despite the decades-old failure to discover genes that cause schizophrenia (as opposed to possibly being associated with it), Balter believed that continuing the search for genes is necessary to help unravel the mysteries of the condition, for the development of new antipsychotic drugs and other interventions, and to develop prevention programs. As I concluded in my 2017 e-book Schizophrenia and Genetics: The End of an Illusion, however, decades of failed gene finding attempts have produced a scientific finding that genes for schizophrenia most likely do not exist.

Balter also discussed recent evidence pointing to the role of childhood trauma, poverty, and other environmental factors, and quoted Norwegian neuroscientist Roar Fosses call for a stronger focus on changing the environment so we can prevent schizophrenia. Balters general conclusion was that environmental data should be added to or incorporated into molecular genetic research, so that researchers can produce statistical models in support of their position that genes and environment interact to produce schizophrenia.

Although schizophrenia is usually presented as a valid disorder that can be reliably identified (diagnosed) by psychiatrists and others, there is plenty of evidence that it isnt.2 And yet, establishing the reliability and validity of a psychiatric disorder is a prerequisite for any attempt to search for genetic influences or genes. Many critics of psychiatry have argued that psychiatric disorders are not reliable or valid discrete illnesses, but instead describe peoples varying psychological responses to having experienced adverse events and environments, or are socially disapproved behaviors or responses to oppression that psychiatry labels as mental disorders.3 Some reject the word schizophrenia entirely, and prefer terms such as psychosis or just madness, [which] would be preferable because they are less strongly associated with the disease model, and enable the uniqueness of each individuals situation to be recognized....

00:00

Hazmat crews called to Royston chemical incident involving 1,200 litres of hydrofluoric acid Fluoride Action Network

Firefighters responded to a report of smoke issuing from an acid room containing 1,200 litres of hydrofluoric acid at 7.30pm at an engineering plant in Orchard Road.

Two crews from Royston, two from Stevenage, one from Baldock & Letchworth and the Decontamination and Environmental Protection Unit from Hemel Hempstead all attended.

Firefighters wore hazmat suits worn as protection against hazardous materials and had to be decontaminated afterwards.

The chemicals were all contained and the incident was over by 9.43pm, a fire service spokesman has confirmed.

*Original article online at http://www.royston-crow.co.uk/news/hazmat-crews-tackle-royston-chemical-spill-involving-1-200-litres-of-hydrochloric-acid-1-5243031

Thursday, 19 October

23:47

Australia ends insurance subsidies for naturopathy, homeopathy, and more Science-Based Medicine

The Australian government has eliminated the insurance subsidy for 17 alternative health practices due to a lack of evidence for efficacy. This is a win for medicine and Australian taxpayers.

23:30

Silver Bay City to allow Northshore Mining to send high fluoride water to city Fluoride Action Network

Excerpt:

Also at the meeting, the council unanimously voted to enter into a memorandum of understanding with Northshore Mining for a trial program allow the plant to send its high fluoride water to the city. The plant is treating the high fluoride water as much as it is able, but now will mix the water with the lower fluoride city water to create a more acceptable blend for both entities.

City engineer John Groutman said there was a concern about the plan affecting mercury levels in the water and that is the reason for the 90 day trial period. John Thomas of the Minnesota Pollution Control Agency approved the plan and required that the water be tested for mercury three times weekly.

Its basically a trial period, utilities department manager Mike Miller said. If anything doesnt work out its 24 hours to tell them its done and they have the same option, they can shut it off at any time.

*See original article titled Silver Bay police proposal gets hairy online at http://www.duluthnewstribune.com/news/4346403-silver-bay-police-proposal-gets-hairy

Notes from FAN:

Levels of fluoride at Northshore Mining from 1992 EPA report.

A 2006 Draft Report on titled, Evaluation of Minnesota Taconite Wet Scrubbers at Minntac, Keewatin Taconite, Hibbing Taconite, and United Taconite. One excerpt:

Two taconite facilities, Northshore Mining and LTV Mining used soda ash (sodium carbonate) water treatment to soften (precipitate calcium carbonate) process water. The tailing basins at these two facilities contain water that has the highest fluoride concentrations of all the Minnesota taconite facilities. Precipitation of calcium carbonate decreased the calcium concentration of the water, which decreased calcium fluoride precipitation; thus resulting in high fluoride concentration in the tailing water.

23:23

Tilbury and Wheatley. Long-time councillor Fluker just learned of status this week Fluoride Action Network

Its a little known fact that Tilbury and Wheatleys municipal drinking water supply does not contain any fluoride.

That information was revealed Wednesday when a study on oral health was presented to the Chatham-Kent Board of Health and when many around the table remarked that the lack of fluoride was news to them.

The Municipality of Chatham-Kent also does not add the chemicals to the drinking water in Ridgetown and Highgate, but thats because the ground water sources for those communities has naturally-occurring fluoride.

The Wheatley water treatment plant, which also supplies Tilbury, did not have the fluoride treatment process when it was built, said Tim Sunderland, general manager of the Chatham-Kent Public Utilities Commission.

It was never part of the certificate of approval for those facilities and we never added that treatment process with that facility in Wheatley, he said.

Even Coun. Bryon Fluker, who has represented Tilbury on Chatham-Kent council since amalgamation, said he learned about his areas fluoridation status earlier this week.

He said the former Town of Tilbury, of which he was a councillor from 1972 to the 1998 amalgamation, had fluoride added because the drinking water was not coming from a Wheatley treatment centre.

It will not be, Im sure, with many of the citizens a major issue, he said. Some citizens who do not like any added chemicals in the water of any kind, it will probably please them to know for sure that theyve been drinking non-fluoridated water for many, many, many years.

Fluker, who is also a commissioner for the PUC, said he has no intention of starting a discussion on this issue at future meetings.

But Coun. Joe Faas, the chair of the board of health, said during Wednesdays meeting he would like to see the PUC look into fluoridating the water in the western part of the municipality.

I think its something we should be pushing to PUC maybe to see to update because its an important factor and thats quite an area thats not covered, he said.

The report on oral health did not provide information based on geographical location within the municipality, but its author said she would like to take a look at that detail level.

Laura Zettler said the Association of Local Public Health Associations has passed resolutions about the benefits of fluoridation.

It is known to be a really efficient and effective way to kind of level the playing field for everybody, said the epidemiologist with the Chatham-Kent Public Health Unit.

Thats one of those social pieces that can impact everybody and really, in terms of health equity, try and reduce some of those disparities in the community that we see.

Zettler acknowledged such a study may be difficult as many residents in the municipality use private wells as their water supply where the fluoride levels are not known.

The...

23:00

Ethical concerns arise for head of controversial stem cell clinic Retraction Watch

Journals are raising ethical concerns about the research of a doctor who offers controversial embryonic stem cell treatments. Two journals have issued expressions of concern for three papers by Geeta Shroff, who was the subject of a 2012 CNN investigative documentary. All cite ethical concerns; one mentions the potential link between the procedure the authors []

The post Ethical concerns arise for head of controversial stem cell clinic appeared first on Retraction Watch.

21:22

These Specific Techniques Allow You To Control Your Dreams PreventDisease.com

New research at the University of Adelaide has found that a specific combination of techniques will increase people's chances of having lucid dreams, in which the dreamer is aware they're dreaming while it's still happening and can control the experience.

15:25

NASA, And The Criminal Denial Of Climate Engineering Geoengineering Watch

GeoengineeringWatch.org 223seDane Wigington GeoengineeringWatch.org NASA is nothing more than a tool for the military industrial complex to carry out their nefarious agendas and to cover up their tracks. No matter how blatant and glaring the ongoing geoengineering atmospheric aerosol spraying is over our heads each and every day, so long as there is an official agency like NASA

02:06

The Unvaccinated Children We Love Voices For Vaccines

My sister-in law wont vaccinated my nieces and nephews.

My cousin has been posting anti-vaccine memes on Facebook.

My best friend is convinced her childs autism was caused by vaccines.

Voices for Vaccines receives many emails, but the ones about a loved one who is vaccine hesitant catch my attention first. Because of the volume of these emails, we created the Talking to Vaccine-Hesitant Loved Ones with Compassion and Confidence toolkit.

Even with the toolkit and a sympathetic ear, too many people find themselves feeling alone on the topic of vaccine hesitant loved ones. I have had the opportunity to talk with more than a few of these folks. I have also had the opportunity to talk to quite a few parents who used to be anti-vaccine, but now vaccinated their children fully.  And I decided that our podcast was the perfect opportunity to match a person from each group together for a conversation.

If you have ever wondered how a person decides not to vaccinate or how someone changes a mind about vaccines, our latest podcast is for you. And if you are a person who is trying to break through a loved ones vaccine hesitancy, we would love to hear from you after you listen!

Vax Talk is the Voices for Vaccines podcast, hosted by Karen Ernst and Blank Childrens Hospital pediatrician Dr. Nathan Boonstra. You can find our podcast page here or on our Cast page.  Subscribe to the podcast via iTunes,...

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