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Tuesday, 15 May


Psychiatry And The Great Fraud Natural Blaze

psychiatry fraud

By Jon Rappoport

Warning: Suddenly withdrawing from psychiatric drugs can be very dangerous, even life-threatening. Withdrawal should be done gradually, supervised by a caring professional who knows what hes doing. See

On the heels of my article celebrating the work of Dr. Peter Breggin, a hero who has exposed the lies of psychiatry, I am reprinting my article, from 2013, which details the fraud.

First, a new introduction.

The history of Western philosophy reveals two main preoccupations. For many centuries, the theme was: What is Deeper Reality? What does it look like? What can learn from it?

Then, in the 19th century, another theme took over: How do human beings perceive reality? How do humans know what they know? What is the nature of the apparatus of human perception?

Finally, as the nascent field of psychology emerged out of philosophy, the (unstated) question was: What are the factors that limit human perception and knowledge? What creates distortion in how humans view the world, other people, and themselves?


The answers were basically: neurosis and psychosis....


Abnormal Behavior Seen In Mice Given Gardasil HPV Vaccine Natural Blaze

Abnormal Behavior Seen In Mice Given Gardasil HPV Vaccine hpv adjuvant

By Brandon TurbevilleNatural Blaze

As vaccine nazis and the Big Pharma corporations repeatedly claim that there is no evidence to show that vaccines are harmful, the science doing just that continues to quietly be published and subsequently ignored by the fanatics determined to push vaccinations on the general public, individual choice be damned.

Many of the studies demonstrating the dangers of vaccines are predictably buried and ignored by the mainstream outlets and, while some are advertised in the alt media, many more simply appear in medical journals never to be seen again.

One such study, Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasilpublished in Immunologic Research in 2016 has also received little attention.



Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India. Fluoride Action Network


.. High fluoride content in ground and surface water is a serious ecological problem for many countries including Algeria, Argentina, Australia, Canada, China, India, Iran, Iraq, Japan, Kenya, New Zealand, Libya, Turkey, South Africa, Srilanka, Thailand and the United States [1].

In this study, 3 districts of Tamil Nadu namely (i) Salem, (ii) Dharmapuri and (iii) Krishnagiri were selected based on the prevalence of high fluoride contaminated water in order to assess its toxicity in fluorosis patients.

As blood plays a major role for the circulation of fluoride in human and animals, it has been reported that blood enzymes profile is altered in fluorosis conditions which in turn provoke other consequences [6,7]. Paraoxonase (PON1) is an important anti-atherogenic and antioxidant enzyme, closely bound with high-density lipoproteins (HDL) that inactivates numerous toxic pollutants [8]. Thus, PON1 has been considered as a significant biomarker for complications caused by toxic pollutants in human as well as aided to predict the intensity of exposure [8,9].

Apart from this, many blood enzymes have been reported as biomarkers for different pathological conditions caused by toxic pollutants. However, there is no detailed report on blood enzymes including PON1 as biomarkers and their altered concentrations in fluorosis conditions.

The study subjects were categorized into 4 groups namely, group I (control), group II (mild), group III (moderate) and group IV (severe). Cases ailing from both skeletal and dental fluorosis were selected in this study. The personal characteristics, duration of fluoride exposure, medical history, family socioeconomic status and lifestyle information of the individual were collected using a predetermined questionnaire.

Of total 508 volunteers, 52 subjects were segregated into group I (28 males and 24 females; age 29 11 y), 112 subjects into group II (76 males and 36 females; age 28 7 y), 136 subjects into group III (78 males and 58 females; age 28 7 y) and 208 subjects into group IV (112 males and 96 females; age 30 11 y). Exclusion criteria were smoking, heart, liver / kidney disease, cancer, chronic inflammation, autoimmune and hematological disorders.

Furthermore, the decreased activity of the membrane bound enzymes, AChE and ATPase indicates that prevalence of memory loss with lower IQ scores as well as defect in signaling and energy metabolism in fluorosis patients. ROC-AUC helped to predict the severity of the fluorosis and significant cutoff values as diagnostic parameters in fluorosis patients.

TABLE 1 Effect of fluoride on biochemical parameters and enzymes. The concentration of serum fluoride in control, mild, moderate and severe category is summarized
TABLE 2 Correlation result of serum fluoride, TBARS of plasma and erythrocyte on lipid profiles
TABLE 3 &#8211...

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Monday, 14 May



Too high / too low blood pressure is a symptom not a disease. Blood pressure and all cardiac disorders are an expression of different imbalances related to our lifestyle: Chemical imbalances (nutrition, hydration, smoking, alcohol, heavy metals, toxins, drugs medication, sugar and wheat poisoning) Emotional imbalances (stress, depression, trauma, psychological shock, burned out syndrome) Physical


Distinguishing Dissociative Disorders from Psychotic Disorders: Compounding Alienation Mad In America

Stories organize us, and bad stories organize us in destructive ways. In this post I will address one example: the story told about how skilled mental health professionals can distinguish between dissociative disorders, with their roots in trauma, and psychotic disorders, which are definitely illnesses of the brain.

Why do professionals attempt to make such a distinction? The idea is that people with dissociative disorders need to be offered caring and skillful therapy which addresses their traumatic past and their fragmented response to it, so they can reorganize in a more integrated way. It is thought that such a psychological approach would be useless for those with psychotic disorders, as their problems are understood to be based in their diseased brains, with drugs being required to control the malfunctions.

If professionals really could reliably distinguish those whose problems came from difficult experiences and who could be helped by therapy and self-understanding, from those whose problems were more organic and who could not be helped in a psychological way, then focusing on making such a distinction would be a useful approach. But if their faith in their ability to do this is really a delusion, then what they are really doing is defining everyone on the psychotic side of the distinction as being beyond human understanding and help, and so inflicting another blow on those already severely troubled.

It is well known that people dissociate when all of the persons mind cannot bear facing what happened directly. Later, parts of the person that did not face the experience may be unable to integrate with the parts that did: each feels alien to the other.

Its what happens next that may be crucial in separating those who will be recognized as having a dissociative disorder from those who will be seen as having a psychotic disorder.

If the person recognizes the alien parts of themselves as being just parts of themselves, even if they seem to be disturbing or even different personalities, then they have a good chance of seeing themselves, and of having professionals see them, as having PTSD or a dissociative disorder. But if they see the alien parts of themselves as being literally aliens, or demons, or CIA agents talking to them through a brain implant, then they will likely be diagnosed as psychotic.

Its important to notice whats happening here: its the person who feels more strongly alienated from parts of themselves who is likely to make the psychotic interpretation about what those parts are  and then its that person who will be seen by the mental health system as having a disorder that is understandable only as brain dysfunction.

We might imagine the following exchange:

Person: I have an alien inside me.

Mental health professional: No, what you have inside you is a defective brain, this is brain pathology or illness.

When we are alienated from som...


A former employee admitted to scientific misconduct. His new institution likely doesnt know. What should you do? Retraction Watch

A few years ago, Richard Miller of the University of Michigan had a serious dilemma: He discovered a former researcher in his lab was doing research somewhere else. Normally, that would be fine except this research had admitted to committing misconduct in Millers lab. Should he tell the researchers new employer? This turns out Continue reading A former employee admitted to scientific misconduct. His new institution likely doesnt know. What should you do?


Nine Rights Every Patient Should Demand Mad In America

From The New York Times: Many medical centers, professional associations, and states have developed patients bills of rights. It is time to develop a Financial Bill of Rights to protect healthcare consumers from unfair changes; here are nine suggestions for what it should include.




Minority Groups Found Less Likely to Get Mental Health Care Mad In America

From California Healthline: Although people of color are much more likely to suffer from severe psychological distress, they are less likely to receive mental health services.

discrimination, along with the direct or indirect consequences of violent crime, can lead to depression, anxiety and heightened psychological stress, especially in the black community.

The shooting death last week of 15-year-old Hannah Bell, while she stood in line with her mother at a hamburger stand in south Los Angeles, will likely lead to mental trauma for the family, the community and other 15-year-old girls, Robinson Flint said.

It could have been anyones 15-year-old, she said. People then take that anxiety, bury it and go to work. People show up at work not really ready and capable of working.'



Los Gsticos del Poder: el Artista Barcelons Luis Quiles Destruye los Apetitos por el Consumismo Obediente AGE OF AUTISM

(An English translation is at the end of this post.) Los gsticos del poder: el artista barcelons Luis Quiles destruye los apetitos por el consumismo obediente Por Adriana Gamondes Age of Autism tiene el honor de anunciar el lanzamiento de...


The Biggest Addictive Drugs To Humanity Are The Threats of Alcohol and Tobacco

A new review published online in the journal Addiction has compiled the best, most up-to-date source of information on alcohol, tobacco, and illicit drug use and the burden of death and disease. It shows that in 2015 alcohol and tobacco use between them cost the human population more than a quarter of a billion disability-adjusted life years.


Weekly Health Quiz: Baking Soda, Oatmeal and Wine Articles

1 Recent research has discovered a novel medical benefit of baking soda, showing that drinking baking soda infused water can be helpful for which chronic health condition?

  • Arthritis and other autoimmune diseases

    Research funded by the National Institutes of Health suggests baking soda may be a safe and effective treatment for autoimmune diseases such as rheumatoid arthritis, by priming your immune system against inflammation. Learn more.

  • Sports-related pain
  • Alzheimer's disease
  • Parkinson's disease

2 Which of the following statements is false?

  • Artificial sweeteners have been linked to an increased risk of obesity and diabetes
  • Artificial sweeteners have been shown to damage vascular function to a greater degree than sugar
  • Artificial sweeteners have been linked to chronic diseases such as heart disease, stroke, Alzheimer's and gut dysbiosis
  • There is no evidence to suggest artificial sweeteners cause health problems of any kind; research supports their use as they are low in or free of calories

    A growing body of research shows artificial sweeteners raise your risk for a number of chronic health problems, including obesity, Type 2 diabetes, heart disease, stroke, Alzheimer's, gut dysbiosis and more. Learn more.

3 According to the Centers for Disease Control and Prevention (CDC), which of the following is the No. 1 killer of Americans under the age of 50?

  • Automobile accidents
  • Opioid overdose

    Opioid addiction is at an all-time high, and opioid overdoses are now the leading cause of death among Americans under the age of 50. Learn more.

  • Cancer
  • ...

Is Ghee Better Than Butter? Articles

By Dr. Mercola

For anyone unfamiliar with the term ghee, another name for it is clarified butter. One difference between ghee and regular butter is that the former doesnt have as many dairy proteins, and there are a host of health advocates who maintain that ghee is the healthier option. Starting with pure butter made from cows milk, the ghee-making process involves heating and separating liquid fats from the milk solids, which become caramelized, and removing the milk solids (which also removes most of the lactose).

Ghee has been used in traditional cooking in India, Pakistan and Southeast Asia for eons, as an oil and as an ingredient, but its also an Ayurvedic go-to for herbal ointments, massage and as a medicinal to remedy rashes and burns. While butter isnt bad for you (especially in comparison with vegetable oil, margarine and the multitude of erroneous, mass-marketed options introduced in the 1960s), ghee, which started as butter, may be the better choice.

For one thing, ghee, heated longer than most clarified butter, is darker and has a nuttier flavor, as well as a higher smoke point, making it easier and healthier for sauting. In fact, including ghee in your diet may bring benefits for several areas, including your heart. Ghee is made up of about 50 percent saturated fat, which was considered a bad thing until the medical community and nutritionists began realizing that fat including saturated fat is good for you.

Interestingly, breast milk contains 54 percent saturated fat. Good fat like this is vital to proper development and your body cant function without it. Even the American Heart Association recommends that people get 5 or 6 percent of their daily food intake from saturated fat, which is still far too low (you actually need upward of 50 to 70 percent healthy fat in your diet for optimal health), but butter deliciously helps to fulfill that requirement.1

So the clarified part is at least part of what makes ghee better than butter, but still, there are caveats. Its also helpful to understand that milk, produced as it typically is in the U.S. today, contains elements that werent (or shouldnt be) meant for human consumption. To explore all the facets of what ghee is, you must first start with milk.

You Must Start With Milk, but Not Just Any Old Milk

You probably already know that most of the milk produced on American farms is highly processed to homogenize and pasteurize it, superficially to remove potential pathogens. However, zapping it with high temperatures, called ultra-high temperature processing (UHT), is also to give the milk a longer shelf life, and the process destroys many of the natural immune-boosting enzymes and vitamins such as B6, B12 and C.


Probiotics Can Lower Blood Pressure and Protect Your Liver Articles

By Dr. Mercola

Your intestinal bacteria are part of your immune system and researchers have discovered that microbes of all kinds play instrumental roles in countless areas of your health. Beneficial bacteria also control the growth of disease-causing bacteria by competing for nutrition and attachment sites in your colon.

This is of immense importance, as pathogenic bacteria and other less beneficial microbes can wreak havoc with your health if they gain the upper hand. It can also affect your weight. Moreover, your gut microbiome which contains 100 times as many genes as your bodys total genome is involved in important chemical reactions that your gut enzymes cannot perform, including fermentation and sulfate reduction.

Importantly, your gut microbiome helps generate new compounds (bacterial metabolites) that can have either a beneficial or detrimental impact on your health. Among the most recent research published are studies showing beneficial gut bacteria, also known as probiotics, benefit your liver function and help lower blood pressure.

Probiotics Influence Liver Function

While a lot of research has focused on the influence gut bacteria have on your gastrointestinal health, recent research presented at the 2018 Experimental Biology meeting in San Diego reveals probiotics also impact your liver function. This study focused primarily on a probiotic called lactobacillus rhamnosus GG (LGG), which is found in many commercial probiotic supplements.

Mice were first given food with added LGG for two weeks, and were then given a toxic dose of acetaminophen, known to cause serious liver damage by increasing oxidative stress. Interestingly, the animals pretreated with LGG had far less liver damage than untreated mice when given an acetaminophen overdose.

According to lead author Bejan Saeedi, doctoral candidate at Emory University,1 "Administration of the probiotic LGG to mice improves the antioxidant response of the liver, protecting it from oxidative damage produced by drugs such as acetaminophen. Earlier animal studies have also shown LGG helps protect against alcoholic liver disease and nonalcoholic fatty liver disease, the latter of which is primarily driven by diets high in sugar and processed foods.

Earlier research by the same team reveals the mechanism behind this finding. It appears LGG protects the liver against oxidative damage by activating Nrf2, a biological hormetic that upregulates superoxide dismutase, catalase and other intercellular antioxidants. Nrf2 not only lowers inflammation, but also improves mitochondrial function and stimulates mitochondr...

Vitamin D Saves Malnourished Children Articles

By Dr. Mercola

Millions of children around the world suffer from malnourishment. While the worst problems are in Asia and Africa, severe acute malnutrition is the most extreme and very obvious when you see the physical toll it takes.

Scientists from Queen Mary University of London (QMUL) and University of the Punjab in Southern Pakistan recently focused on the latter region, where nearly 1.5 million children are dangerously malnourished, to analyze the effectiveness of vitamin D3 supplementation in restoring the health of such children. The Conversation notes:

Severe acute malnutrition is the most extreme and visible form of undernutrition. Affected children have very low weight for their height and severe muscle wasting; they may also have swollen feet, face and limbs. About 20m [million] children are affected worldwide, mainly in Asia and Africa where it is a major cause of death.

Children with severe acute malnutrition also commonly have low levels of vitamin D. This micronutrient is important for muscle and bone health and for maintaining a healthy immune system.1

A total of 185 severely malnourished children, aged 6 months to 4 years, completed the follow-up as well as the trial, which was published by The American Journal of Clinical Nutrition.2 The first group of 93 children was randomly selected to receive two oral 5-milligram (mg) doses of vitamin D dissolved in olive oil while the remaining 92 were given a placebo with the same taste: olive oil without the vitamin D.

None of the children or their parents knew which children were in which group; and both groups were started on the standard treatment for malnourishment: a high-energy ready-to-use therapeutic food (RUTF) paste (called Plumpy Nut), containing a small amount of vitamin D and other essential micronutrients, but which reliably correct deficiency.

Vitamin D3 Slows the Trajectory of Delayed Childhood Development

After just two months of being given the supplement, the children began to gain significant weight, exhibit measurably better muscle tone, motor and language development and bone health, as well as improved immune systems, according to the researchers involved in the clinically-governed trial. The scientists explained:

The primary outcome was the proportion of participants gaining (more than)15 percent of baseline weight at 8 weeks after starting ready-to-use therapeuti...


Pain in Right Temple of Head: Causes of Headache in the Right Temple & Treatments Healthy and Natural World

Headaches that affect your right temple affect many people and is a common source of pain and discomfort. A headache on one side of your head can cause you to feel a wave of nausea, fatigued, or even have vision disturbances. Very often the right temple pain can feel like sharp jabbing stabs behind your eye or it could be like unrelenting pounding aches. Even dull throbs on the right side of your head can affect your daily activities.

Thankfully, the cause of headache pain that only affects your right temple is rarely anything to worry about. Blocked sinuses, anxiety, stress, a lack of sleep are all reasons for feeling like the right side of your head is throbbing. Many people also suffer from cluster headaches or migraines find that they tend to affect just the right side or left side of their head.

Even though the majority of headaches behind one eye dont have a serious cause, they can leave you debilitated, frustrated, and in a lot of discomfort.

In this article, I will look at why you may have a headache on the right side of your head. Knowing what kind of headache you have, can sometimes help to avoid situations that can aggravate the headache pain even more. At the end of the article, you will find useful home remedies to treat pain in your right temple.

What is the Right Temple?

Your temples are located on either side of your forehead just behind your eye. Doctors on MedicineNet say that each temple is just above your cheekbone and in front of each ear.1

There are some physical reasons why some types of headaches only affect your temples or cause pain just behind one eye. Dr. Christopher Harris, an expert in maxillofacial surgery, says that important nerves and arteries in the brain run through your temple region.2 If these arteries or nerves become inflamed or irritated, you will feel varying degrees of pain on just one side of your head.

Your temples are the softest part of your skull and gently pressing on your temples or massaging them can help to relieve headaches naturally.


The right temple

The right temple

Pain on Right Side of Your Head: What Does it Mean?

Having pressure-like aching or stabbing pain behind your right eye usually means that you will experience other symptoms of temple pain....


Is Eugenics Alive, Well And Actually Thriving Today? Natural Blaze

Op-Ed by Catherine J. Frompovich

What is eugenics, you may be wondering. There are confused interpretations of that term, especially when it is not recognized for what it originally had been intended to mean, i.e.,

Frankly, I really do not accept that meaning which, somehow, seems to be sanitized and even glamorized, in my opinion. Why do I say that? The reasons are many, especially since eugenics usually has meant the culling of humans and their lives either by clandestine or open-ended means of population reduction, some of which include legal abortion and legal assisted suicide called euthanasia.

Euthanasia is illegal in most of the United States. Physician aid in dying (PAD), or assisted suicide, is legal in the states of Washington DC, Pennsylvania, California, Colorado, Oregon, Vermont, Hawaii, and Washington; its status is disputed in Montana. The key difference between euthanasia and assisted suicide is who administers the lethal dose of medication: Euthanasia entails the physician or another third party administering the medication, whereas in assisted suicide it is the patients prerogative to self-administer the medication in order to end their life. [2]



My guide to fluoride: Fluoride is a tooths best friend Fluoride Action Network


Fluoride is a natural mineral found in drinking water and many foods. It plays an important role in your childs oral health by strengthening their tooth enamel, making it more resistant to tooth decay. Acid attacks you childs teeth, but fluoride reduces the amount of acid bacteria can produce and even helps to reverse the damage this acid causes. The addition of fluoride to water has been proven to reduce tooth decay by 40-60%.


As soon as they get their first tooth. Children under the age of three should use toothpaste with a fluoride level of at least 1000ppm (parts per million). After three years, their toothpaste should contain a fluoride level of between 1350ppm and 1500ppm. Its important you supervise their brushing until they are around seven years old. Children tend to swallow most of their toothpaste, so ensure they use only a pea-sized amount. Older children can use an adult toothpaste.


Did you know?

Research into fluoride dates back as far as 1901 when a communal water source in Colorado Springs was found to affect the colour of everyones teeth.


This is a simple treatment whereby a dentist or nurse will paint a varnish containing concentrated levels of fluoride onto the surface of your childs tooth. The varnish strengthens tooth enamel, helping to protect their teeth from decay. From the age of three, all children should be given a fluoride varnish application at least twice a year or more often if needed. At mydentist, all children over the age of three years old can have fluoride varnishes for free.


There have been many studies into the health benefits of fluoride. These have shown fluoride to be of great benefit to dental health, helping to reduce tooth decay and causing no harmful side effects to general health. Children who swallow too much fluoride over long periods of time can develop white spots on their teeth. However, the risk of developing white spots as a result of fluoride varnish is very low.

*Original article on the website of {my}Dentist at

Online as of May 13, 2018...


Millions of parents putting childrens health at risk by not knowing dental care facts, according to research Fluoride Action Network

It is essential that parents regularly take their children to the dentist as soon as their baby has their first tooth or turns one whichever is sooner


Top Tips for good dental health in children

Take your child to the dentist as soon as their first tooth comes through.

Give your child water or cold milk before bed if they need a bedtime drink.

Encourage your child to spit out excess toothpaste after they brush, but not to rinse or gargle.

Give your child a soft, small headed toothbrush for brushing.

Use a timer to ensure your child brushes for the full, recommended, two minutes.

Your child should be brushing twice a day, before bed and at least one other time during the day.

Always check the fluoride levels in the toothpaste you buy your child Fluoride is a natural mineral found in drinking water and many foods. It plays an important role in your childs oral health by strengthening their tooth enamel, making it more resistant to tooth decay.

*Original article online at



The Surprising Truth about Garcinia Cambogia Based on Science Healthy and Natural World

Many people are interested in finding out the truth about garcinia cambogia because of conflicting reviews about its health benefits. Many scientific studies indicate that garcinia cambogia supplements help to lose weight and reduce body fat. There are also claims that garcinia cambogia extracts are beneficial in lowering cholesterol and regulating blood sugar levels. However, some research into the effect of garcinia cambogia on health indicates that it could affect liver function.

Because of these contradictory claims, many people wonder: Is it safe to take garcinia cambogia to boost health?

Using garcinia cambogia for weight loss became popular when Dr. Oz endorsed it as a weight loss supplement. The evidence was based on the fact that garcinia cambogia contains hydroxycitric acid (HCA). This compound helps a person feel fuller for longer and also reduces lipids (a type of fat in the blood).

In this article, I aim to find out the truth about garcinia cambogia and find out if there are any side effects of taking this supplement. You will also find out how to use garcinia cambogia together with apple cider vinegar to help speed up weight loss.

What is Garcinia Cambogia?

Garcinia cambogia is a fruit that grows in India and Southeast Asia and is popular in local cuisine. The garcinia cambogia plant produces a fruit that looks like a small pumpkin. The journal Fitoterapia says that the fruits peel is used in fish curries because of its sour acidic taste. Garcinia cambogia supplements are made from the rind of garcinia cambogia.1

Garcinia cambogia is also called garcinia gummi-gutta, Malabar tamarind, garcinia, or brindle berry.

According to the journal Evidence-Based Complementary and Alternative Medicine, garcinia cambogia extracts contain hydroxycitric acid. It is this compound that has been connected with weight loss, reducing belly fat, improving blood sugar levels, and treating the symptoms of rheumatism.2

What Dr. Oz Said About Garcinia Cambogia And Weight Loss?

In 2012, on his popular TV show, Dr. Oz proclaimed that garcinia cambogia was the holy grail of fat loss. He said that it was possible to use this natural supplement as a fat buster and a person could lose weight without the need of diet, exercise, or effort. Dr. Oz based his claims on research that pure garcinia cambogia pills suppress appetite and help the body burn fat faster.

However, skeptics point to other studies that show the effect of garcinia cambogia extracts is only minimal on weight loss. This has led many people to question if there is any truth about the effectiveness of garcinia cambogia...


Benzo Withdrawal: Why Dont Doctors Know? Mad In America

This question runs through the head of so many who have experienced benzodiazepine withdrawal: Why? Why doesnt my doctor/provider know what is happening to me? Why does he/she disregard that I do know what is happening to me? Why do they refuse to confirm my concerns or support me? Benzodiazepine tolerance and withdrawal are not new. Many have endured and more will in the future. So, why isnt it simple to diagnose and treat? As both a health care provider and a withdrawal sufferer, Id like to offer an inside and outside perspective on this question.

I am a 48-year-old wife, mother, grandmother and nurse practitioner. I am now 26 months off of 0.5 mg of Klonipin that I took as prescribed, once daily, for 15 years. I was prescribed this medication to treat my insomnia which was a side effect of the Cymbalta I was taking at the time (which I have since discontinued). In 2015 I began having symptoms of heightened anxiety/agitation, terrible intrusive thoughts, fatigue, palpitations, feeling like the skin on my arms was burning, gastrointestinal disturbance, shakiness and dizziness. I went to my providers (I was seeing a family doctor and an endocrinologist) who, after many tests, said my symptoms were likely because of my anxiety and that I should increase the dose of the Klonipin. I refused. I did not want to play that game in which I would have to keep increasing my dose to get the same effect. I knew that the long-term effects could be damaging; I knew, as well, that I would eventually hit a maximum dose and then what? It was then that I decided I wanted off of this drug.

My primary doctor disregarded my concerns, saying that this drug was tame and such a low dose that I shouldnt have any concern and that I would likely need it for life because of my chemical imbalance. At that time I was also seeing a psychiatrist, who was actually the prescriber, so I went to her and discussed my concerns. She was supportive of the fact that I wanted to stop but her suggestion for tapering was quite fast. By now, I had been reading the Ashton Manual (which my doctors had never heard of) so I suggested to my psychiatrist that I cross over to Valium which, with her approval, I did, but I went from 0.5 mg of Klonipin (the equivalent of 10 mg of Valium) to 2 mg of Valium overnight.

It was much too big and too fast of a cut and I immediately went into a tailspin. My symptoms were as follows: severe agitation/anxiety, intrusive thoughts, dizziness, heart palpitations/pounding, nausea/vomiting, severe cold intolerance, a burning sensation in my arms along with an icy sensation in my bones, inner restlessness, shallow breathing, urinary frequency, and probably more. The thoughts that were entering my mind were frightening so I went to the E.R. They performed multiple lab tests and an abdominal CT, all which were normal. So what did they do? They gave me Ativan. The LAST thing I nee...


Rooting Out Bedhead by Maurine Meleck: Autism and Other Brushes with Chaos AGE OF AUTISM

Join us in congratulating our dear friend, autism Grandmother extraordinaire Maurine Meleck on the publication of her poetry book. We have a copy for two lucky readers. But we'd love you to buy a copy! $16 includes shipping. Please use...


The Gestics of Power: Barcelona Artist Luis Quiles Destroys Appetites for Consumption and Obedience AGE OF AUTISM

(A Spanish translation is at the end of this post.) By Adriana Gamondes Age of Autism is honored to announce the release of a new book by Barcelona artist Luis Quiles titled The Antisocial Networks which Quiles describes as a...


DEA Knowingly Gave Addicts and Drug Dealers Licenses to Prescribe OpioidsFueling the Epidemic Natural Blaze

By Jack Burns

As thousands of Americans die each year from opioid overdoses, an independent investigation into the Drug Enforcement Agencys conduct has found that it has been issuing controlled substance licenses to drug dealers, drug addicts, convicted felons and dead people, which is just one of the many things that have fueled the current crisis.

The investigation, which was conducted by The Daily Caller, noted that in 2006, only 510,000 individuals and organizations held controlled substance licenses. As of March 2018, that number had increased drastically to 1.7 million licenses. According to the report:

One dentist, for example, admitted to helping an outlaw motorcycle gang manufacture methamphetamine in the early 2000s, which resulted in two years of jail time, a DEA document said. Hed previously been caught with meth several times and admitted to a history of substance abuse with alcohol, marijuana, methamphetamine and cocaine.

That same dentist was given a license to prescribe controlled substances in 2012. A doctor was also given a license, in 2009, even though he had previously had a run-in...


A Mothers Day Message for Grieving Mothers A Message of Hope Health Impact News

Spring Tulips Happy Mother's Day Card

by Terri LaPoint
Health Impact News

To the mother whose children have been medically kidnapped or taken from them by Child Protective Services, the idea of Mothers Day can seem like a cruel mockery.

There is no greater grief in the entire world than to lose a child. How can there be hope today when the children you carried in your womb are not with you?

You are a mother. Nothing will ever change that. No judicial decree, no act of a social worker, and no piece of paper can ever undo the fact that you are the mother of your children.

Even if a judge writes on a piece of paper that your parental rights are terminated, no judge is powerful enough to ever stop you from being your childs parent.

There is an eternal bond between parent and child that no force on the planet can take away from you or your child, no matter how much they may try. It is written in every cell of your childs body. It is written on their heart. You are part of their soul.

Even if your baby was taken away from you at birth, you carried your baby in your womb and formed a bond that no one can ever replace.

This isnt wishful thinking or empty words to try to comfort hurting people. It is science. It is psychology. It is Scripture.

Science and Psychology Affirm You Are Your Childs Mother

No scientist or doctor will ever be able to remove your DNA from your childs body. Your children dont carry the DNA of a foster parent in their cells.

They carry yours. It is your genes that they will pass on to their own children when they grow up.

Newborn babies can tell the difference between their own parents and other adults.

David Chamberlain, PhD, a pioneer in birth psychology, and one of the founders of APPPAH (Association for Pre- and Perinatal Psychology and Health, wrote:

In experiments shortly after birth, babies recognize their mothers voice and prefer her voice to other female voices.

In the delivery room, babies recognize their fathers voice and recognize specific sentences their fathers have spoken, especially if the babies have heard these sentences frequently while they were in the womb.

After birth, babies show special regard for their native language, preferring it to a foreign language. (Source.)

Babies carry these early memories with them throughout life,...


Kidney ailment becoming major health threat in Telangana Fluoride Action Network

Kidney ailment is more prevalent in villages such as Guruja, Khunikhasa, Kanchanpelli, Jalaja and Devnagar in the district.

ADILABAD: Kidney ailment is emerging as one of the major disease affecting the local population  of erstwhile Adilabad district. In the last three years, over 25 people, including children died of kidney ailment and over 300 people are undergoing dialysis at private and government hospitals in Hyderabad and district headquarters government hospitals. Kidney ailment is more prevalent in villages such as Guruja, Khunikhasa, Kanchanpelli, Jalaja and Devnagar in the district.

Currently, in Khunikhasa village, which has a population of 250 people, 13 persons are suffering from kidney ailment. The family of Bheemrao Kamble, who died due to kidney ailment a year ago, is struggling to make ends meet. His wife has psychological issues and she has been finding it difficult to feed her six children.

Human Rights Forum state secretary Attram Bhujanga Rao told Express that his organisation had identified villages facing fluoride water problems. He said that after knowing about the seriousness of the diseases, the doctors organised medical camps  and provided medicines, but a permanent solution to the problem of kidney ailments still lacks. There is high quantity of fluoride and sulphate present in the water in these villages, which is leading to many diseases, the Human Rights Forum state secretary said.

The Telangana state government has set up dialysis centres in Adilabad RIMS Government Hospital, Mancherial and Nirmal district headquarters hospitals and Utnoor community health centre. These centres will be helpful to them.

*Original article online at



A Mothers Day Message for Grieving Mothers A Message of Hope Medical Kidnap

Spring Tulips Happy Mother's Day Card

by Terri LaPoint
Health Impact News

To the mother whose children have been medically kidnapped or taken from them by Child Protective Services, the idea of Mothers Day can seem like a cruel mockery.

There is no greater grief in the entire world than to lose a child. How can there be hope today when the children you carried in your womb are not with you?

You are a mother. Nothing will ever change that. No judicial decree, no act of a social worker, and no piece of paper can ever undo the fact that you are the mother of your children.

Even if a judge writes on a piece of paper that your parental rights are terminated, no judge is powerful enough to ever stop you from being your childs parent.

There is an eternal bond between parent and child that no force on the planet can take away from you or your child, no matter how much they may try. It is written in every cell of your childs body. It is written on their heart. You are part of their soul.

Even if your baby was taken away from you at birth, you carried your baby in your womb and formed a bond that no one can ever replace.

This isnt wishful thinking or empty words to try to comfort hurting people. It is science. It is psychology. It is Scripture.

Science and Psychology Affirm You Are Your Childs Mother

No scientist or doctor will ever be able to remove your DNA from your childs body. Your children dont carry the DNA of a foster parent in their cells.

They carry yours. It is your genes that they will pass on to their own children when they grow up.

Newborn babies can tell the difference between their own parents and other adults.

David Chamberlain, PhD, a pioneer in birth psychology, and one of the founders of APPPAH (Association for Pre- and Perinatal Psychology and Health, wrote:

In experiments shortly after birth, babies recognize their mothers voice and prefer her voice to other female voices.

In the delivery room, babies recognize their fathers voice and recognize specific sentences their fathers have spoken, especially if the babies have heard these sentences frequently while they were in the womb.

After birth, babies show special regard for their native language, preferring it to a foreign language. (Source....


Parents pay more than TWICE as much for kids toothpaste that do the same job as adults Fluoride Action Network

Many opt for expensive childrens brands assuming they contain less fluoride and are therefore safer

Parents can pay more than twice as much for kids toothpastes that do the same job as adults.

Many opt for expensive childrens brands assuming they contain less fluoride and are therefore safer.

But the Sunday People found nearly all kids pastes have as much fluoride as adult brands yet always cost more.

Other brands failed to contain recommended levels of fluoride, which is crucial for healthy teeth.

Tesco Freshmint toothpaste, 100ml, 1450ppm, 50p, 50P per 100ml

Tesco Steps mild mint (3-5 years), 75ml, 1450ppm, 1, 1.34 per 100ml

These include Boots Kids Mild Mint for zero to two years with 500ppm, while the Department of Health recommends children up to three use a paste with 1,000ppm.

Lidls Dentalux Sweet Mint for zero to five years also has 1,000ppm failing under guidelines for children above three. Its Dentalux Sweet Mint for six and above has 1,450ppm in a 100ml tube for 69p yet the adult 125ml with the same fluoride is 50p.

The findings come as it emerges a quarter of five-year-olds have tooth decay.Nicola Innes, professor of paediatric dentistry at the University of Dundee, said: Untreated tooth decay in children is the most prevalent condition in the world.

Boots Kids mild mint (0-2 years) 500ppm 50ml Boots 1, 2 per 100ml

Toothpaste manufacturers have long marketed brands aimed at children. Many are often more expensive than standard adult brands But look beyond the colourful packaging and often th...


Adding fluoride to Darlingtons water supply is examined Fluoride Action Network

INVESTIGATIVE work has been launched to consider whether fluoride should be added to the drinking water of a town with a high proportion of children with tooth decay.

Darlingtons director of public health Miriam Davidson said the towns council was taking part with neighbouring authorities in a technical appraisal to look at the feasibility of introducing a community fluoridation scheme.

Among the issues being examined is whether water fluoridation can be introduced in one borough without having to introduce it in a neighbouring area.

Darlington Borough Councils health and wellbeing board heard the authority was also gathering evidence from professionals about fluoridation.

The meeting was told while Hartlepool, which has natural fluoride in its water, had 15 per cent of five-year-olds with decayed, filled or missing teeth, the figure in Darlington was 35 per cent.

Members were told while Stocktons figure was ten per cent below that of Darlington, part of Stockton is supplied with water by Hartlepool.

Ms Davidson said water fluoridation was both the most effective and cheapest intervention.

She added: Water fluoridation can reduce the likelihood of experience of decay as a safe public health measure. It is suitable for consideration in localities where dental decay are a cause for concern. It is a valuable public health intervention.

The inequality with poor oral health is stark. There are some parts of our community where oral health is much poorer.

Ms Davidson said while some areas of the region had seen improvements in childrens oral health, there had been no measurable improvement in the prevalence of tooth decay experience in five-year-old children in Darlington over the past few years.

She said: This council has not made a commitment to introducing a community water fluoridation scheme, but that responsibility since 2013 has accrued to the local authority.

*Original article online at

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Sunday, 13 May


More Than a Mom AGE OF AUTISM

By Cathy Jameson We got rid of cable a few years ago. Disappointed with rising fees and discouraged that my children were picking up bad habits from characters on the kids shows they were watching, it was one of the...


Happy Mothers Day Wishes From Dr. Mercola Articles

By Dr. Mercola

I want to wish all of you moms out there a Happy Mother's Day today. If you're a mom, I want you to know I think you have one of the toughest jobs in the world. You play a key role in building our next generation. Mothering is a full-time job, in addition to whatever career or commitments you have outside of your home. Your job doesn't end when your kids leave home either. Your adult children of all ages can still find comfort and strength from your words and embrace.

dr mercola mom

Mother's Day, Without Mom

Today is the first Mother's Day without my mom. She passed away unexpectedly on July 6, 2017, two days before my 63rd birthday. My sister called me early that morning; it was a Thursday. As soon as I heard the tone of her voice, I knew something was wrong. I was afraid she was going to tell me that our father passed away. He was 88 at the time. When she said it was mom, time stood still.

For a few moments, I just held the phone in my hand and said nothing. I was somewhat in shock and definitely in denial. Maybe this was a just a nightmare. Losing her left me feeling devastated. In the days that followed, a flood of memories surfaced without warning or permission, and the feelings that came with them were overwhelming at times. My memories sabotaged my sleep and derailed my best efforts to accomplish my daily tasks.

In the beginning, I felt a physical void that's difficult to describe. I called my sister several times a day and cried with her. I imagine that many of you might also be grieving this year, and my sympathy goes out to you in a fresh new way. Some of you might also feel a sense of emptiness or loss surrounding your relationship with your mom.

Maybe it just isn't what you hoped it would be, due to circumstances beyond your control. Or she might be physically present but emotionally unavailable due to illness. Your roles have reversed, and you are caring for her the way she cared for you as a child. Reading the book "Letting Go, the Pathway to Surrender,"1 by Dr. David Hawkins really helped me in the early days after I lost my mom. David was a brilliant man and this was his last book before he passed. I deeply regret I never had the opportunity to interview him.

My Mom Believed in Me

dr. mercola and mom childhood

I am tremendously grateful that my mom was supportive of my dreams during my childhood, and she encouraged me in my goals and aspirations throughout my life whether...

Important Facts on Appendicitis: Types, Symptoms and Treatment Articles

Of all the organs inside the human body, the most misunderstood one is probably the appendix. Its often described to be useless and unimportant, and is thought to be a remnant of human evolution. Charles Darwin concluded that it may be an organ that cavemen used to digest tree bark and other fibrous plant materials.1

Today, when talk of the appendix arises, most people tend to think of it as a good for nothing body part that may potentially lead to painful inflammation. But theres actually more to this organ than what most people think.

What Is the Appendix and What Does It Do?

The appendix is found in the lower right portion of your abdomen. This slimy, finger-shaped organ is attached to the cecum, a small pouch thats part of the intestines (the cecum is considered to be the beginning of the large intestine) and is part of your gastrointestinal tract.2

The appendix is thin and small, measuring only 2 to 4 inches (5 to 10 centimeters) long.3 For a long time, the appendix has been regarded as an organ that does not serve any function, and that removing it will not harm a person. But now, research has made it clear that it may be useful after all.

According to scientists in France and Australia, the appendix may actually play a role in your immunity, as it has an important function for your gut bacteria.

Published in Nature Immunology, their study showed that the appendix with the help of white blood cells known as innate lymphoid cells (ILCs) works as a reservoir for good bacteria, which are essential for good gut health and healing from infections.4 When certain diseases eliminate the healthy bacteria in your gut, the appendix works as a safe house for some of these probiotics.

The researchers say that these findings should make people rethink whether the appendix is irrelevant to their health.Once the bodys immune system has gotten rid of the infection, the bacteria will emerge from the biofilm of the appendix, and then recolonize your gut, bringing it back to its healthy state.5 According to Gabrielle Belz, a professor at Melbournes Walter and Eliza Hall Institute:

"We've found that ILCs may help the appendix to potentially reseed 'good' bacteria within the microbiome or community of bacteria in the body. A balanced microbiome is essential for recovery from bacterial threats to gut health, such as food poisoning."6

Real Trouble Arises...

If You Love Dessert, You'll Surely Adore This Creamy Mint Chocolate Pudding Articles

Many people often skip dessert, afraid that they might not only add inches to their waist but also trigger a sugar overload. But if you carefully select the right ingredients and exercise your creativity, any recipe, even sweet treats, can become healthy and wholesome.  


Our featured recipe today is a delicious and guilt-free variation of a dessert favorite: pudding. Traditional pudding recipes often use dairy milk and sugar, and are cooked and thickened with cornstarch, but this one doesnt need all those items. You dont even have to turn on your stove.


Plus, this mint chocolate pudding is made with one of my favorite foods: avocado. You can be sure that this recipe is not only scrumptious and creamy, but chockfull of nutrients as well a delightful treat that every member of your household, whether kids or adults, will love.




4 ripe avocados

3/4 cup raw organic cacao powder

1 tsp. Dr. Mercolas organic vanilla extract

3/4 cup homemade almond or coconut milk

3 Tbsp. monk fruit

3 drops organic peppermint oil



  1. Combine all ingredients in blender and mix until smooth.
  2. Can serve immediately or refrigerate for a couple of hours to serve chilled.


Take Your Dessert Game to the Next Level With This Wholesome Pudding Recipe


This pudding recipe doesnt have any added sugar or fructose, which can wreak havoc on your health. Rather, the sweetness naturally comes from two fruits, namely avocados and monk fruit.


Avocado: One of the Healthiest Foods You Can Eat


Avocado is becoming well-known in the cooking world because of its versatility, mildly sweet flavor and the creamy texture it adds to dishes. Its loaded with close to 20 essential health-boosting nutrients, including B vitamins, fiber, vitamin E, potassium and folate. I personally eat an avocado every day, and I believe that this has made great strides in improving my wellbeing.


But thats not what makes it stand out from other fruits. Rather, avocado is a rich source of monounsaturated fat that the body can easily burn for energy. It also allows your body to absorb fat-soluble nutrients from other foods you eat it with. For more on the health benefits that you can get from avoc...


Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions. GreenMedInfo

PMID:  Clin Exp Obstet Gynecol. 2016 ;43(4):529-533. PMID: 29734542 Abstract Title:  Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model. Abstract:  PURPOSE OF INVESTIGATION: To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats.MATERIALS AND METHODS: Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control, Group 2: aloe vera endometriosis formation, and Group 3: aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats.RESULTS: All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 20.4 mm and after treatment the volumes dropped to 28.9 14.9 mm3 (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.91.4 mm and in Group 1, 118.9 20.0 mm3 (p = 0.001). Likewise, similar changes wereobserved in the histopatological scores.CONCLUSION: The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions.

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Long-term consumption of artificial sweeteners may have harmful effects on cognition and hippocampal integrity in rats. GreenMedInfo

PMID:  J Biochem Mol Toxicol. 2018 Apr 16:e22053. Epub 2018 Apr 16. PMID: 29660801 Abstract Title:  Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study. Abstract:  The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group (n = 6) received regular tap water, whereas other groups received aspartame (3 mg/kg/day, n = 6,) or saccharin (3 mg/kg/day, n = 6) or sucralose (1.5 mg/kg/day, n = 6) in the drinking water. Following 6 weeks, the passive avoidance learning (PAL) test was performed to evaluate the neurobehavioral effects of sweeteners. The brains were assessed for lipid peroxides, neuron count, and Glial fibrillary acidic protein (GFAP) immunohistochemistry. Our results demonstrated that chronic intake of sweeteners significantly impaired PAL performance in all groups. Hippocampal CA1-CA3 areas revealed significantly lower neuronal count in aspartame and increased GFAP expression in all groups. Brain lipid peroxides were significantly higher in all groups. Our findings suggest that long-term consumption of artificial sweeteners may have harmful effects on cognition and hippocampal integrity inrats.

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P. major protected renal tissue against doxorubicin induced renal inflammation. GreenMedInfo

n/a PMID:  Avicenna J Phytomed. 2018 Mar-Apr;8(2):179-187. PMID: 29632849 Abstract Title:  Doxorubicin-induced renal inflammation in rats: Protective role of. Abstract:  Objective: The aim of the present study was to evaluate the possible protective effect of() extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXRand Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7day of the experiment. Tumor necrosis factor-alpha (TNF-) production and monocyte chemoattractant protein-1 (MCP-1) expression levels were assessed in the left kidney. Serum creatinine concentration and osmolarity were determined on the 1, 14, 21, 28and 35days of the experiment. Results: DXR caused a significant increase in renal expression of MCP-1 and TNF- production compared to control animals. Administration of dexamethasone, vitamin E andextract significantly improved the expression of these inflammatory mediators compared to DXR group. Compared to day 1 in DXR group, serum osmolarity showed a significant increase on days 21, 28 and 35. Also, on these days, serum osmolarity in DXR group was significantly higher than that on the same days in control group. In Vit E+DXR and Ext 1200+DXR groups, there was no significant changes in serum osmolarity among different days of the study. However, in these groups, serum osmolarity on days 21, 28 and 35 showed a significant decrease compared to the same days in DXR group. Conclusion: Present results suggest that hydroethanolic extract ofprotected renal tissue against DXR-induced renal inflammation.


Additive benefits of twice forest bathing trips in elderly patients with chronic heart failure. GreenMedInfo

PMID:  Biomed Environ Sci. 2018 Feb ;31(2):159-162. PMID: 29606196 Abstract Title:  Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure. Abstract:  Chronic heart failure (CHF), a clinical syndrome resulting from the consequences of various cardiovascular diseases (CVDs), is increasingly becoming a global cause of morbidity and mortality. We had earlier demonstrated that a 4-day forest bathing trip can provide an adjunctive therapeutic influence on patients with CHF. To further investigate the duration of the impact and the optimal frequency of forest bathing trips in patients with CHF, we recruited those subjects who had experienced the first forest bathing trip again after 4 weeks and randomly categorized them into two groups, namely, the urban control group (city) and the forest bathing group (forest). After a second 4-day forest bathing trip, we observed a steady decline in the brain natriuretic peptide levels, a biomarker of heart failure, and an attenuated inflammatory response as well as oxidative stress. Thus, this exploratory study demonstrated the additive benefits of twice forest bathing trips in elderly patients with CHF, which could further pave the way for analyzing the effects of such interventions in CVDs.

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Bitter melon powder protects against obesity-associated fatty liver disease. GreenMedInfo

PMID:  Biomed Environ Sci. 2017 Aug ;30(8):611-615. PMID: 28807102 Abstract Title:  Bitter Melon Powder Protects against Obesity-associated Fatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced Obesity. Abstract:  This study explored how bitter melon powder (BMP) alters the colonic microenvironment during the development of obesity-associated fatty liver in rats. We observed that BMP effectively inhibited the body weight gain and lipid accumulation in the liver, ameliorated glucose intolerance, and increased the colon weight after an 8-week treatment compared to that in the high-fat diet (HFD) group. BMP significantly decreased fecal water toxicity towards HT-29 cells, as revealed by the cell counting kit (CCK)-8 assay results, and the mRNA expression of Toll-like receptor 4 (TLR4) in colon mucosa. Additionally, gut permeability in the BMP group was restored to normal levels. Finally, BMP alleviated the inflammatory state of the rat colon mucosa and liver tissues as well as the systemic inflammation.

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Momordica charantia total fruit juice elicited a Th2-immunoproliferative capacity. GreenMedInfo

PMID:  Biomed Res Int. 2017 ;2017:9478048. Epub 2017 Jul 25. PMID: 28812026 Abstract Title:  Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of AntidiabeticFruit Juice. Abstract:  The mechanism of action of the antidiabetic capacity ofis still under investigation. Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices ofon human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines. In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation. Under PHA stimulation, both juices potentiated plant-induced T cell proliferation. However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation. Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-production. Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices. Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable. The saponins present in total juices were undetectable after filtration. Moreover, both juices had appreciable antioxidant capacity. Our study supports the type 1 antidiabetic effect of filtered fruit juicewhich may be related to its immunosuppressive and T-helper 2 cell inducing capacities. Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.

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The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis. GreenMedInfo

PMID:  Biomed Pharmacother. 2018 Feb ;98:491-498. Epub 2017 Dec 27. PMID: 29287196 Abstract Title:  The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis. Abstract:  Inspite of the wide facilities for controlling cancer growth, there are little drugs to inhibit its metastasis or prevent its angiogenesis. Discovering such natural or synthetic multi-targeted agent that might strike different targets is considered as a vital goal for tumor controlling. In a previous study, the chemoprotective effect of methanol extract of Momordicacharantia (MEMC) on albino western rats bearing hepatocarcinogenesis was evaluated. The mechanism by which MEMC exert its anticancer properties was unknown. Therefore, we aimed in this study to investigate the possible role of MEMC as anti-proliferative, anti-angiogenic and anti-metastatic agent to exert its chemoprotective effect. The study was conducted on sixty albino western rats divided into six groups, 10 rats each. Diethylnitrosamine (DENA) was injected intraperitoneally (i.p.) at a dose of 200mg/kg body weight once, 2 weeks later rats were received carbon tetrachloride (CClsubcutaneously (3ml/kg/week) continued for 10 weeks. MEMC was orally produced to rats (40mg/kg) alone, as well as before, at the same time and after DENA injection. Cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), caspase-3,-8 (Casp-3,-8), histone deacetylase (HDAC) and matrixmetalloproteinases-2,-9 (MMP-2,-9) were evaluated. MEMC treatment significantly decreased Cox-2, VEGF, HDAC and MMP-2,-9 and increased Casp-3,-8 as compared to DENAgroup,which demonstrated that the anticancer effect of MEMC may be through the inhibition of angiogenesis, proliferation and metastasis and the activation of apoptosis. The improvement in before-treated group was more pronounced than that in after- and simultaneous-treated groups, indicating thatMEMC may act as a prophylactic agent more than being a therapeutic agent.

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Prophylactic administration of polysaccharides from M. charantia reduced ethanol-induced gastric injury. GreenMedInfo

PMID:  Int J Biol Macromol. 2018 May ;111:193-199. Epub 2018 Jan 4. PMID: 29307809 Abstract Title:  Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition. Abstract:  This study investigated the therapeutic role of polysaccharides from M. charantia and their mechanism of action against ethanol-induced gastric ulcers in rats. Their effects were determined through macroscopic evaluation of the gastric cavity (gastric ulcer index [GUI]), changes in PGE, lipid peroxidation (malondialdehyde), antioxidant systems (catalase and reduced glutathione), inflammatory markers (tumor necrosis factor- [TNF-], interleukin-6 [IL-6], and myeloperoxidase [MPO]), apoptotic markers (caspase 3, Bax, and Bcl-2), nuclear factor-B (NF-B [p65]), and histopathological staining (H&E and PAS). Pretreatment with MCP (300mg/kg p.o.) attenuated the severity of ethanol-induced gastric mucosal damage, reductions in GUI, histopathologic aberrations, and neutrophil invasion, and PGEupregulation. These actions were similar to those of omeprazole, a reference anti-ulcer drug. MCP repressed gastric inflammation through the reduction of MPO, TNF-, and IL-6, and prevented gastric oxidative stress through the inhibition of lipid peroxides with the concomitant enhancement of glutathione and catalase activity. Apoptotic markers indicated that MCP suppressed Bax and caspase-3 activity and enhanced the anti-apoptotic protein Bcl-2, which favored cell survival. MCP downregulated NF-B and upregulated IB. Our study results suggested that the prophylactic administration of MCP reduced ethanol-induced gastric injury in rats through the suppression of gastric inflammation and oxidative stress, predominantly via NF-B inhibition.

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This data confirms the use of Momordica charantia fruit in the treatment of autoimmune type 1 diabetes. GreenMedInfo

PMID:  Evid Based Complement Alternat Med. 2017 ;2017:3707046. Epub 2017 Nov 28. PMID: 29317893 Abstract Title:  Effectiveness of Antihyperglycemic Effect of: Implication of T-Cell Cytokines. Abstract:  Background/Objective: We investigate the effect of antidiabeticfruit juice on T cells' differentiation, through plasmatic cytokine quantification in type 1 diabetic rats (T1D).Methods: Malerats were rendered diabetic by the injection of five low doses of streptozotocin. Then, animals were treated withfruit juice for 28 consecutive days. Plasmatic levels of Th1 interleukin- (IL-) 02 and interferon- (IFN-), Th2 (IL-4), and regulatory (IL-10) cytokines were determined in rats.Results: We observed that fruit juice induced a significant decrease in blood glucose of T1D rats. Besides, the concentrations of IL-2 and IFN-significantly increased while those of IL-4 and IL-10 diminished in diabetic rats compared to control animals. Interestingly, after treatment withfruit juice, IL-4 and IL-10 levels significantly increased in diabetic rats, while IL-2 and IFN-concentrations decreased, suggesting a Th2 phenotype in these animals. Phytochemical analysis of the fruit juice revealed the presence of tannins, flavonoids, and coumarins, compounds which possess antioxidant activity.Conclusion: This study shows thatfruit juice, by lowering the hyperglycemia, induced a shift of proinflammatory Th1 phenotype in T1D rats towards a favorable anti-inflammatory Th2 status. These effects might be due to the presence of antioxidant compounds in the juice and confirms the use of this plant in the treatment of autoimmune type 1 diabetes.

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MAP30 markedly induces apoptosis in U87 and U251 cell lines. GreenMedInfo

PMID:  Oncol Lett. 2018 Apr ;15(4):5833-5840. Epub 2018 Feb 16. PMID: 29556310 Abstract Title:  MAP30 promotes apoptosis of U251 and U87 cells by suppressing the LGR5 and Wnt/-catenin signaling pathway, and enhancing Smac expression. Abstract:  Significant antitumor activity ofanti-human immunodeficiency virus protein of 30 kDa (MAP30) purified fromhas been the subject of previous research. However, the effective mechanism of MAP30 on malignant glioma cells has not yet been clarified. The aim of the present study was to investigate the effects and mechanism of MAP30 on U87 and U251 cell lines. A Cell Counting Kit-8 assay, wound healing assay and Transwell assay were used to detect the effects on U87 and U251 cells treated with different concentrations of MAP30 (0.5, 1, 2, 4, 8 and 16M) over different periods of time. Proliferation, migration and invasion of each cell line were markedly inhibited by MAP30 in a dose- and time-dependent manner. Flow cytometry and fluorescence staining demonstrated that apoptosis increased and the cell cycle was arrested in S-phase in the two investigated cell lines following MAP30 treatment. Western blot analysis demonstrated that leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5) expression and key proteins in the Wnt/-catenin signaling pathway were apparently decreased, whereas second mitochondria-derived activator of caspase (Smac) protein expression significantly increased with MAP30 treatment in the same manner. These results suggest that MAP30 markedly induces apoptosis in U87 and U251 cell lines by suppressing LGR5 and the Wnt/-catenin signaling pathway, and enhancing Smac expression in a dose- and time-dependent manner.

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This demonstrates the potential benefits of bitter melon extract in preventing and delaying the progression of oral dysplasia to squamous cell carcinoma. GreenMedInfo

PMID:  Cancer Prev Res (Phila). 2018 Apr ;11(4):185-186. Epub 2018 Mar 20. PMID: 29559516 Abstract Title:  Immunomodulatory Effects ofExtract in the Prevention of Oral Cancer. Abstract:  In recent times, bitter melon extract (BME) has gained significant attention for its anticancer efficacy against various malignancies. In this issue,and colleagues show that BME prevents the development of 4-nitronitroquinoline 1-oxide-induced oral dysplasia and squamous cell carcinoma (SCC) in an immunocompetent mouse model. Importantly, gene ontology and pathway analyses revealed an elevated expression of s100a9, IL23a, IL1, and PDCD1/PD1 of immune system during oral cancer development, which was significantly suppressed by BME. Overall, this study demonstrates the potential clinical benefits of BME in preventing and delaying the progression of oral dysplasia to SCC..

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These results indicate that bitter melon polysaccharide may be useful as an anti-diabetic agent. GreenMedInfo

PMID:  Int J Biol Macromol. 2018 Apr 10 ;115:45-52. Epub 2018 Apr 10. PMID: 29649536 Abstract Title:  Characterization of Momordica charantia L. polysaccharide and its protective effect on pancreatic cells injury in STZ-induced diabetic mice. Abstract:  A polysaccharide with a molecular weight of 13,029Da was isolated from Momordica charantia (MCP) fruit and purified by ion-exchange and size-exclusion chromatography. The isolated polysaccharide MCPIIa contained L-Rha, D-GalA, D-Gal, D-Xyl, L-Ara in a molar ratio of 12:3.05:19.89:5.95:56. IR spectrum and NMR studies indicated that the MCPIIa sugar units were linked, via-glycosidic bonds, to a large number of arabinofuranose, glucuronic acid, and xylopyranosyl residues. In addition, the hypoglycemic effect of MCPIIa was investigated in streptozotocin (STZ)-induced diabetic mice. After STZ-induction, MCPIIa (100, 200, or 300mg/kg body weight) was administered orally, once daily, for 28days. Glycemia in STZ-diabetogenic mice was significantly reduced, and compared with diabetes mellitus (DM) mice, serum insulin concentration increased significantly, following MCPIIa administration. Transmission electron microscopy showed an alleviation of STZ-lesions in pancreatic tissue from mice treated with MCPIIa. These results indicate that MCPIIa may be useful as an anti-diabetic agent.

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Leaf extracts of both M.charantia and O.basilicum will serve as a measure against induced pancreatic cancer. GreenMedInfo

PMID:  J Tradit Complement Med. 2018 Apr ;8(2):282-288. Epub 2017 May 3. PMID: 29736383 Abstract Title:  Analysis of Kras gene from induced pancreatic cancer rats administered withandleaf extracts. Abstract:  Objective: To analyze K-ras gene from induced pancreatic cancer rats administered withandleaf extracts.Methods: Twenty-five (25) adult rats weighing between 90-120 g were divided into 5 groups namely RA, RB, RC, NC and PC, each group had 5 rats. The PC which served as the control was fed with normal fish meal and water ad libitum; the NC which is the negative control received 20 mg/ml/week of Nitrosamines only while other groups received different concentrations of aqueous extract of bothand(200 mg, 100 mg, 50 mg) and Nitrosamine. Qualitative phytochemical screening of the aqueous extract of bothandwas carried out. The extraction of DNA was done using Jena Bioscience DNA preparation kit and the protocol was based on the spin column based genomic DNA purification from blood, animal and plant cells. Agarose gel electrophoresis was used to analyze the K-ras gene extracted from the pancreas tissues of experimental rats while hematoxylinand eosin staining was used for histological assay.Results: Phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, saponins and glycosides inwhile saponins, tannins and glycosides were discovered in. Significant reduction in the weight of rats treated with 200 mg of aqueous extracts ofandwhile rats that were dosed with nitrosamines only showed a slight increase in weight in the first three weeks when compared to the positive control. Histological studies revealed that there is both enlargement and reduction in the islet cell size, with one of the sections showing a normal islet cell size. While the agarose gel electrophoresis revealed that there may be possibility of prevention of damage to k-ras gene as a result of the effect of plants extract.Conclusion: This work has shown that the leaf extracts of bothandwill serve as a measure against induced pancreatic cancer in rats.

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Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics GreenMedInfo

PMID:  J Ethnopharmacol. 2018 Apr 24 ;216:1-7. Epub 2018 Jan 12. PMID: 29339109 Abstract Title:  Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Impaired glucose tolerance and diabetes mellitus have become major health issues even in non-industrialized countries. As access to clinical management is often poor, dietary interventions and alternative medicines are required. For bitter gourd, Momordica charantia L., antidiabetic properties have been claimed.AIM OF THE STUDY: The main objective of the intervention study was to assess antidiabetic effects of daily bitter gourd consumption of 2.5g powder over the course of eight weeks among prediabetic individuals.MATERIALS AND METHODS: In a randomized placebo-controlled single blinded clinical trial, 52 individuals with prediabetes were studied after consuming a bitter gourd or a cucumber juice. For reducing the impact of between subject differences in the study population, a crossover design was chosen with eight weeks for each study period and four weeks washout in between. Fasting plasma glucose was chosen as the primary outcome variable.RESULTS: Comparing the different exposures, the CROS analysis (t=-2.23, p=0.031, r=0.326) revealed a significant difference in the change of FPG of 0.31mmol/L (5.6mg/dL) with a trend (R=0,42387). The number of 44 finally complete data sets achieved a power of 0.82, with a medium-to-large effect size (Cohen's d 0.62). The effect was also proven by a general linear mixed model (estimate 0.31; SE: 0.12; p: 0.01; 95%CI: 0.08; 0.54). Not all participants responded, but the higher the initial blood glucose levels were, the more pronounced the effect was. No serious adverse effects were observed.CONCLUSIONS: Bitter gourd supplementation appeared to have benefits in lowering elevated fasting plasma glucose in prediabetes. The findings should be replicated in other intervention studies to further investigate glucose lowering effects and the opportunity to use bitter gourd for dietary self-management, especially in places where access to professional medical care is not easily assured.

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Combined therapy regulates the inflammatory process and oxidative stress and contributes to immune protection on patients with T2D. GreenMedInfo

PMID:  Med Sci Monit. 2018 May 8 ;24:2887-2900. Epub 2018 May 8. PMID: 29735963 Abstract Title:  Acupuncture Combined with Hydrotherapy in Diabetes Patients with Mild Lower-Extremity Arterial Disease: A Prospective, Randomized, Nonblinded Clinical Study. Abstract:  BACKGROUND The aim of this pragmatic study was to explore the intervention of acupuncture combined with hydrotherapy and perceived effects in type 2 diabetic patients with recently diagnosed, mild, lower-extremity arterial disease (LEAD) in comparison with a control group. MATERIAL AND METHODS One hundred twenty-six diabetes patients who were diagnosed mild LEAD according to ankle-brachial blood pressure index (ABPI) and peripheral neuropathy symptom were randomly assigned to either an experimental (n=64) or control group (n=62). The experimental group attended and completed (1) a 30-min session of acupuncture in certain selected points, and (2) a 30-min hydrotherapy exercise every 2 days for 15 weeks. The outcome parameters were assessed at baseline, after intervention, and at 6-week follow-up. RESULTS The intervention was associated with an improvement in leg flow conductance and partial physical capacities, including chair-sit-and-reach, the walking impairment questionnaire (WIQ), and physical component summary score (PCS), compared to the control group. The treatment benefits were sustained throughout the 6-week follow-up endpoint. There was no difference in fasting glucose levels, Hb1Ac, blood pressure, or BMI after the intervention. At the endpoint of 6-week follow-up, acupuncture plus hydrotherapy appeared to reduce inflammatory response by decreasing IL-6, TNF-, malondialdehyde, and SOD, and increasing glutathione. CONCLUSIONS Acupuncture plus hydrotherapy, without significant glycemic-controlling effects in the type 2 diabetic patients with mild LEAD, exerts a measurable benefit in disease-specific physical functions and health-related quality of life.Our results suggest that the combined therapy regulates the inflammatory process and oxidative stress and contributes to immune protection.

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Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging. GreenMedInfo

PMID:  Cell Stem Cell. 2018 May 3 ;22(5):769-778.e4. PMID: 29727683 Abstract Title:  Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Abstract:  Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration.

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Geoengineering Watch Global Alert News, May 12, 2018, #144 Geoengineering Watch

887hrDane Wigington New studies now prove that the percentage of autism cases increase in direct proportion to the quantity of vaccines administered, this should not come as any surprise. Covert biowarfare against unsuspecting populations has always been a part of the equation for heavily militarized nations. Complex and resource intense societies are becoming increasingly unmanageable and unstable (largely due to


Newly developed molecule to improve pharmaceuticals draws inspiration from natures toolbox Fluoride Action Network

However, there is only one fluorination reaction known to occur in nature. And this process is performed by complex and highly specialized enzymes that are difficult to replicate. Now, scientists have developed a new, streamlined molecule that can do the work of enzymes but be designed and controlled minutely. This new catalyst transforms a safe, affordable fluoride salt into fluorinated organic molecules. In addition to improved pharmaceuticals, fluorinated molecules can also act as useful radiotracers in high-resolution 3-D medical imaging technology, such as PET (positron emission tomography) scanning.

Robert Paton, an associate professor in the Department of Chemistry at Colorado State University, contributed to the new study, which was published this week in Science. The work was conceived and led by Professor Vronique Gouverneur at the University of Oxford, with design and synthesis provided by Gabriele Pupo and Francesco Ibba in the Gouverneur lab, and the mode of action uncovered using quantum mechanical calculations by Oxfords David Ascough and Paton.

This new catalyst performs the same function as the biological enzyme, but is a fraction of the size and is more widely applicable, Paton said. In addition, the designed catalyst can be used to incorporate fluorine into a variety of organic molecules, whereas the naturally occurring enzyme is limited to just one target.

Designing a new molecular claw

Catalysts speed up chemical reactions, creating new compounds from the original ingredients. The catalyst that Paton and his colleagues developed is specifically tuned to integrate fluorine atoms into a new organic product. It works like a claw crane arcade game, Paton said of the catalysts mode of action. Youre trying to pick one fluffy toy out of many and hold on tightly. In a broad sense, thats what our catalyst does. Surrounded by other chemicals, it selectively binds fluoride anions using three hydrogen-bonds effectively a molecular claw and then positions it to add the substrate, or target location.

Newly developed molecule to improve pharmaceuticals draws inspiration from nature's toolbox

With such specific tasks, catalysts are extremely challenging to create from scratch. Youre trying to construct a molecule with a specific function and a precise three-dimensional shape, Paton said.

Thats where Patons work comes in. His lab specializes in computational analysis and uses quantum mechanics to predict structure and behavior. In creating a new catalyst, computer-aided design allows you to visualize atomic-scale structures in the same way you would design a new airplane or new house, he said. In the past, he added, the discovery of new functional molecules has...


Detecting Cancer: Can You Trust All The Tests? Natural Blaze

By Jon Rappoport

Obviously, a false diagnosis of cancer would be a disaster.

Im not talking about all tests for cancer. Ive only looked into two. This is what Ive discovered.

There is a blood test, which looks for a bio-marker labeled CA125. There are doctors who will tell you that a highly positive result indicates a high probability of cancer.

Imagine being a patient on the receiving end of that news.

But wait. If you go to other sourcesand no, Im not talking about alternative practitioners, Im talking about the mainstreamyoull get a distinctly different view.

How about a quite prestigious organizationthe Mayo Clinic?

A CA 125 test measures the amount of the protein CA 125 (cancer antigen 125) in your blood.

A CA 125 test may be used to monitor certain cancers during and after treatment. In some cases, a CA 125 test may be used to look for early signs of ovarian cancer in people with a very high risk of the disease.

A CA 125 test isnt accurate enough to use for ovarian ca...


Your Shampoo, Hair Spray And Skin Lotion May Be Polluting The Air Natural Blaze

By Matthew Coggon, University of Colorado

Millions of Americans apply personal care products every morning before heading to work or school. But these products dont stick to our bodies permanently. Over the course of the day, compounds in deodorants, lotions, hair gels and perfumes evaporate from our skin and eventually make their way outdoors. Now theres new evidence to suggest that these products are major sources of air pollution in urban areas.

For decades, motor vehicles were considered the primary source of air pollutants in major U.S. cities. Vehicle exhaust contains multiple pollutants that worsen air quality, including nitrogen oxides, particulate matter and volatile organic compounds (VOCs) a group of reactive gases that contribute to smog formation.

Thanks to advances in catalytic converters and improvements in fuel economy, combined emissions of common pollutants from cars have...


The Anti-Vax Movement Has Collapsed BolenReport

And Im Not One Bit Surprised There could be Mandatory Childhood Vaccine programs in the majority of States within three years if we dont make a shift. Opinion by Deplorable Consumer Advocate Tim Bolen In 2015 I watched from the sidelines as the California Anti-SB277 (Mandatory Childhood Vaccines) activists conducted the worst campaign I have ever Continue reading The Anti-Vax Movement Has Collapsed

The post The Anti-Vax Movement Has Collapsed appeared first on BolenReport.

Saturday, 12 May


Vanillin could counteract apoptosis induced by rotenone by preserving mitochondrial functions and antioxidant action. GreenMedInfo

PMID:  Evid Based Complement Alternat Med. 2015 ;2015:626028. Epub 2015 Nov 17. PMID: 26664453 Abstract Title:  Neurosupportive Role of Vanillin, a Natural Phenolic Compound, on Rotenone Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells. Abstract:  Vanillin, a phenolic compound, has been reported to offer neuroprotection against experimental Huntington's disease and global ischemia by virtue of its antioxidant, anti-inflammatory, and antiapoptotic properties. The present study aims to elucidate the underlying neuroprotective mechanism of vanillin in rotenone induced neurotoxicity. Cell viability was assessed by exposing SH-SY5Y cells to various concentrations of rotenone (5-200nM) for 24h. The therapeutic effectiveness of vanillin against rotenone was measured by pretreatment of vanillin at various concentrations (5-200nM) and then incubation with rotenone (100nM). Using effective dose of vanillin (100nM), mitochondrial membrane potential, levels of reactive oxygen species (ROS), and expression patterns of apoptotic markers were assessed. Toxicity of rotenone was accompanied by the loss of mitochondrial membrane potential, increased ROS generation, release of cyt-c, and enhanced expressions of proapoptotic and downregulation of antiapoptotic indices via the upregulation of p38 and JNK-MAPK pathway proteins. Our results indicated that the pretreatment of vanillin attenuated rotenone induced mitochondrial dysfunction, oxidative stress, and apoptosis. Thus, vanillin may serve as a potent therapeutic agent in the future by virtue of its multiple pharmacological properties in the treatment of neurodegenerative diseases including PD.

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Vanillin attenuated behavioural impairments, neurochemical deficts, oxidative stress and apoptosis in a model of Parkinson's disease. GreenMedInfo

PMID:  Neurochem Res. 2016 Aug ;41(8):1899-910. Epub 2016 Apr 2. PMID: 27038927 Abstract Title:  Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson's Disease. Abstract:  Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson's disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.

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Vanillin can be a potential lead molecule for the development of non-toxic agents for the treatment of breast cancer either alone or combined with DOX. GreenMedInfo

PMID:  Pathol Res Pract. 2016 Sep ;212(9):767-77. Epub 2016 Jun 22. PMID: 27493101 Abstract Title:  The synergistic effect between vanillin and doxorubicin in ehrlich ascites carcinoma solid tumor and MCF-7 human breast cancer cell line. Abstract:  Despite the remarkable anti-tumor activity of doxorubicin (DOX), its clinical application is limited due to multiple organ toxicities. Products with less side effects are therefore highly requested. The current study investigated the anti-cancer activities of vanillin against breast cancer and possible synergistic potentiation of DOX chemotherapeutic effects by vanillin. Vanillin (100mg/kg), DOX (2mg/kg) and their combination were administered i.p. to solid Ehrlich tumor-bearing mice for 21days. MCF-7 human breast cancer cell line was treated with vanillin (1 and 2mM), DOX (100M) or their combination. Protection against DOX-induced nephrotoxicity was studied in rats that received vanillin (100mg/kg, ip) for 10days with a single dose of DOX (15mg/kg) on day 6. Vanillin exerted anticancer effects comparable to DOX and synergesticlly potentiated DOX anticancer effects bothin-vivo and in-vitro. The anticancer potency of vanillin in-vivo was mediated via apoptosis and antioxidant capacity. It also offered an in-vitro growth inhibitory effect and cytotoxicity mediated by apoptosis (increased caspase-9 and Bax:Bcl-2 ratio) along with anti-metasasis effect. Vanillin protected against DOX-induced nephrotoxicity in rats. In conclusion, vanillin can be a potential lead molecule for the development of non-toxic agents for the treatment of breast cancer either alone or combined with DOX.

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Vanillin protects dopaminergic neurons against inflammation-mediated cell death. GreenMedInfo

PMID:  Int J Mol Sci. 2017 Feb 12 ;18(2). Epub 2017 Feb 12. PMID: 28208679 Abstract Title:  Vanillin Protects Dopaminergic Neurons against Inflammation-Mediated Cell Death by Inhibiting ERK1/2, P38 and the NF-B Signaling Pathway. Abstract:  Neuroinflammation plays a very important role in the pathogenesis of Parkinson's disease (PD). After activation, microglia produce pro-inflammatory mediators that damage surrounding neurons. Consequently, the inhibition of microglial activation might represent a new therapeutic approach of PD. Vanillin has been shown to protect dopaminergic neurons, but the mechanism is still unclear. Herein, we further study the underlying mechanisms in lipopolysaccharide (LPS)-induced PD models. In vivo, we firstly established rat models of PD by unilateral injection of LPS into substantia nigra (SN), and then examined the role of vanillin in motor dysfunction, microglial activation and degeneration of dopaminergic neurons. In vitro, murine microglial BV-2 cells were treated with vanillin prior to the incubation of LPS, and then the inflammatory responses and the related signaling pathways were analyzed. The in vivo results showed that vanillin markedly improved the motor dysfunction, suppressed degeneration of dopaminergic neurons and inhibited microglial over-activation induced by LPS intranigral injection. The in vitro studies demonstrated that vanillin reduces LPS-induced expression of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), IL-1, and IL-6 through regulating ERK1/2, p38 and NF-B signaling. Collectively, these data indicated that vanillin has a role in protecting dopaminergic neurons via inhibiting inflammatory activation.

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Vanillin treatment suppressed cancer stem-like phenotypes in NCI-H460 lung cancer cells. GreenMedInfo

PMID:  Int J Oncol. 2017 Apr ;50(4):1341-1351. Epub 2017 Feb 17. PMID: 28259926 Abstract Title:  Suppression of cancer stem-like phenotypes in NCI-H460 lung cancer cells by vanillin through an Akt-dependent pathway. Abstract:  Cancer stem cells (CSCs) have been reported as a major cause of cancer metastasis and the failure of cancer treatment. Cumulative studies have indicated that protein kinase B (Akt) and its downstream signaling pathway, including CSC markers, play a critical role in the aggressive behavior of this cancer. In this study, we investigated whether vanillin, a major component in Vanilla planifolia seed, could suppress cancer stemness phenotypes and related proteins in thehuman non-small cell lung cancer NCIH460 cell line. A non-toxic concentration of vanillin suppressed spheroid and colony formation, two hallmarks of the cancer stemness phenotype, in vitro in NCIH460 cells. Western blot analysis revealed that the CSC markers CD133 and ALDH1A1 and the associated transcription factors, Oct4 and Nanog, were extensively downregulated by vanillin. Vanillin also attenuated the expression and activity of Akt, a transcription regulator upstream of CSCs, an action that was confirmed by treatment with the Akt inhibitor perifosine. Furthermore, the ubiquitinationof Akt was elevated in response to vanillin treatment prior to proteasomal degradation. This finding indicates that vanillin can inhibit cancer stem cell-like behavior in NCIH460 cells through the induction of Akt-proteasomal degradation and reduction of downstream CSC transcription factors. This inhibitory effect of vanillin may be an alternative approach in the treatment against lung cancer metastasis and its resistance to chemotherapy.

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Vanillin might be a potential anti-metastatic agent that suppresses metastatic gene expression and migration activity under hypoxia. GreenMedInfo

PMID:  Int J Mol Sci. 2017 Mar 1 ;18(3). Epub 2017 Mar 1. PMID: 28257048 Abstract Title:  Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1 mRNA Expression in Malignant Melanoma Cells. Abstract:  Recent studies have shown that vanillin has anti-cancer, anti-mutagenic, and anti-metastatic activity; however, the precise molecular mechanism whereby vanillin inhibits metastasis and cancer progression is not fully elucidated. In this study, we examined whether vanillin has anti-cancer and anti-metastatic activities via inhibition of hypoxia-inducible factor-1 (HIF-1) in A2058 and A375 human malignant melanoma cells. Immunoblotting and quantitative real time (RT)-PCR analysis revealed that vanillin down-regulates HIF-1 protein accumulation and the transcripts of HIF-1 target genes related to cancer metastasis including fibronectin 1 (), lysyl oxidase-like 2 (), and urokinase plasminogen activator receptor (). It was also found that vanillin significantly suppresses HIF-1 mRNA expression and de novo HIF-1 protein synthesis. To understand the suppressive mechanism of vanillin on HIF-1 expression, chromatin immunoprecipitation was performed. Consequently, it was found that vanillin causes inhibition of promoter occupancy by signal transducer and activator of transcription 3 (STAT3), but not nuclear factor-B (NF-B), on. Furthermore, an in vitro migration assay revealed that the motility of melanoma cells stimulated by hypoxia was attenuated by vanillin treatment. In conclusion, we demonstrate that vanillin might be a potential anti-metastatic agent that suppresses metastatic gene expression and migration activity under hypoxia via the STAT3-HIF-1 signaling pathway.

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Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells. GreenMedInfo

PMID:  Mol Cell Biochem. 2018 Jan ;438(1-2):35-45. Epub 2017 Jul 25. PMID: 28744811 Abstract Title:  Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells. Abstract:  Human calcium/calmodulin-dependent protein kinase IV (CAMKIV) is a member of Ser/Thr kinase family, and is associated with different types of cancer and neurodegenerative diseases. Vanillin is a natural compound, a primary component of the extract of the vanilla bean which possesses varieties of pharmacological features including anti-oxidant, anti-inflammatory, anti-bacterial and anti-tumor. Here, we have investigated the binding mechanism and affinity of vanillin to the CAMKIV which is being considered as a potential drug target for cancer and neurodegenerative diseases. We found that vanillin binds strongly to the active site cavity of CAMKIV and stabilized by a large number of non-covalent interactions. We explored the utility of vanillin as anti-cancer agent and found that it inhibits the proliferation of human hepatocyte carcinoma (HepG2) and neuroblastoma (SH-SY5Y) cells in a dose-dependent manner. Furthermore, vanillin treatment resulted into the significant reduction in the mitochondrial membrane depolarization and ROS production that eventually leads to apoptosis in HepG2 and SH-SY5Y cancer cells. These findings may offer a novel therapeutic approach by targeting the CAMKIV using natural product and its derivative with a minimal side effect.

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Vanillin is a potent antioxidant, anti-inflammatory and anti-fibrotic agent. GreenMedInfo

PMID:  Cytokine. 2017 11 ;99:260-265. Epub 2017 Aug 4. PMID: 28784590 Abstract Title:  Vanillin as a new modulator candidate for renal injury induced by cisplatin in experimental rats. Abstract:  Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg/kg body weight) daily for 4weeks to combat this hazard. The present results have demonstrated significant attenuation of oxidative stress and renal injury where reduced glutathione (GSH) showed significant increase along with malondialdehyde (MDA) decrease. Fibrotic markers like fibroblast growth factor-23 (FGF-23), transforming growth factor-1 (TGF-1), inflammatory mediators such as nuclear factor-B (NF-B) and tumor necrosis factor- (TNF-) showed also significant decrease in vanillin treated rats as compared with the control group. Renal function showed also significant improvement where urea and creatinine demonstrated significant decrease and the histopathological study presented a good support to the biochemical markers results. Our conclusion that vanillin is a potent antioxidant, anti-inflammatory and anti-fibrotic agent. Additionally, it is a good modulator candidate for the renal injury induced by cisplatin intake.

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Vanillin was an effective bioactive compound against psoriatic skin inflammation. GreenMedInfo

PMID:  J Agric Food Chem. 2017 Nov 29 ;65(47):10233-10242. Epub 2017 Nov 14. PMID: 29073354 Abstract Title:  Oral Administration of Vanillin Improves Imiquimod-Induced Psoriatic Skin Inflammation in Mice. Abstract:  Vanillin is one of the most widely used flavoring products worldwide. Psoriasis is a chronic inflammatory skin disorder. The interleukin-23 (IL-23)/interleukin-17 (IL-17) axis plays a critical role in psoriasis. Here, we analyzed the effect of vanillin on imiquimod (IMQ)-induced psoriatic skin inflammation in mice. Mice were treated topically with IMQ on the back skin and orally with various amounts of vanillin for 7 consecutive days. Vanillin significantly improved IMQ-induced histopathological changes of skin in a dose-dependent manner. The thickness and number of cell layers of epidermis were reduced by 29 14.4 and 27.8 11%, respectively, in mice given 100 mg/kg of vanillin. A microarray showed that a total of 9042 IMQ-upregulated genes were downregulated by vanillin, and the biological pathways involved in the immune system and metabolism were significantly altered by vanillin. The upregulatedexpressions of IL-23, IL-17A, and IL-17F genes were suppressed by vanillin, with fold changes of -3.07 0.08, -2.06 0.21, and -1.62 0.21, respectively. Moreover, vanillin significantly decreased both the amounts of IL-17A and IL-23 and the infiltration of immune cells in the skin tissues ofIMQ-treated mice. In conclusion, our findings suggested that vanillin was an effective bioactive compound against psoriatic skin inflammation. Moreover, the downregulation of IL-23 and IL-17 expression suggested that vanillin was a novel regulator of the IL-23/IL-17 axis.

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In Worst-Case Scenario, Chemical Release At Superior Refinery Would Double Evacuation Area Fluoride Action Network

Entire City Of Superior, Much Of Duluth Would Be Affected

A tank containing hydrofluoric acid at the Husky Energy oil refinery recently forced a temporary evacuation in Superior after a series of explosions and fires there. The highly toxic chemical could have prompted an evacuation of more than 25 miles if that tank had been full.

At the most, that tank can hold just under 78,000 pounds of hydrofluoric acid, according to a 2017 hazardous materials response plan for the refinery. In the worst-case scenario, Douglas County Emergency Management Director Keith Kesler said they would evacuate people up to 26 miles from the refinery. But, he said how many people would be evacuated depends on which way the wind is blowing.

If it were to go south as it did in this event, the number would be significantly lower than if it were a wind that was blowing it over across the city into Duluth, he said. Then, the numbers would be higher.

Kesler said thats the largest evacuation requirement of any chemical in the Twin Ports for which they may have to provide emergency response.

The refinery stores a combined roughly 60 million gallons of gasoline, crude oil, asphalt and fuel oils.

The 2017 hazardous materials response plan for the refinery also includes information on other chemicals at the facility, including chlorine, ammonia and sulfuric acid. All those chemicals have evacuation zones, but they dont extend beyond more than a couple miles from the refinery. A worst-case scenario release of hydrofluoric acid from the refinery would cover the entire city of Superior and much of Duluth, according to the plan.

This area would extend into rural Douglas, Carlton, and St. Louis counties, the plan reads. The use of numerous major road, rail, and water routes would be affected.

Kesler said county officials conduct site visits of the refinery each year to confirm the amount of chemical on site. They also prepare a document that includes information about facilities that would need to be evacuated, including schools, nursing homes and hospitals. However, he noted the evacuation is not the first line of defense against any release of hydrofluoric acid at the refinery.

There were many other things in place, said Kesle...

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