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Monday, 16 October

00:59

Mainstream Scientists Call New Vaccine Autism In Mice Study Fake Science Vaxxter

A recent study which linked aluminum found in vaccines to autism development in mice has caused a frenzy of outrage amongst those who say the study is scientific fraud. The author of the study, Christopher Shaw,...

The post Mainstream Scientists Call New Vaccine Autism In Mice Study Fake Science appeared first on Vaxxter.

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Sunday, 15 October

22:43

Child Abuse, Mental Health and Mental Illness Mad In America

Mental health and mental illness (in the abstract, without ever being clearly defined) are discussed far more than the abusive conditions which often create the suffering that lasts a lifetime.

Recently in a support group Im part of, a young woman spoke of being whipped with belts by her parents. My shut down heart woke up and felt something.

Since I was a child, child abuse has been a subject of my subconscious interest. As a kid I had recurring dreams of children of different races than my own being hit and abused by their parents. This was the most common type of dream I had.

My own home life included violence towards the children, and growing up in New York City where I took public transportation daily as a teenager, I often witnessed child abuse in public. But not just on the subway.

At the ice skating rink I saw a woman smack her son for being in the wrong area. I then witnessed her saying to him, Im sorry I hit you, on the bench next to me as I took off my sneakers and put on my ice skates.

I saw my friends in my drama class get smacked by their mom in the hallway, and another family friend nurse a bloody nose after his mom hit him, on the front stairs to their house, in front of everyone.

A lot of blood and fascia move around my body as I recount these small incidents. A lot of blood and fascia is stagnated in my being that got frozen in terror when the physical assault of children happened in my own family.

I can feel that on a level of cause and effect, the abuse of children that I experienced firsthand and second hand, and still experience residually and vicariously, has led to most of the suffering I have experienced as an adult.

Thats a pretty bold statement to make in a culture that blames the suffering on mental health problems and prescribes pills to check out of the pain. Yet in my blood and breath, its one thing I know very well to be true.

Writing about children being hit or whipped is the most cathartic thing I can think of. (It also terrifies me.)

This is because a big part of the abuse was the silencing and subsequent distraction.

After abuse in my own family, there often followed love and generosity. While these gestures had elements of honesty, they were also control and silencing mechanisms.

As an older sibling of divorced and suffering parents, I was far too protective of my parents to break the code of silence about the violence they inflicted.

This silence has eaten away at me my whole life. It has ruined my life; it has led to all kinds of addictive behaviors to check out of that pain, the pain of children being hit by adults. The layers of shame and guilt that get buried deep underneath mental health diagnoses, pills, health problems, addictions or simply unhappy adults who spend their days escaping in one way or another.

The medical and psychiatric systems often aid and abet this abuse. Psychiatrists dont...

21:00

Perfectly Understandable AGE OF AUTISM

By Cathy Jameson The face a person makes when they learn that Ronan's "autism" really means that he was vaccine injured can be full of: a) bewilderment b) doubt c) curiosity d) sadness e) all of the above When the...

16:00

Savory Chicken and Veggie Muffins Articles

Recipe by Pete Evans

 

Muffins are enjoyed by people all over the world, and are distinguished by the lack of yeast in their dough when baked.[i] However, I generally dont recommend foods that use grains because they can lead to a host of health problems due to their gluten content.[TNAS1] 

 

So how can you enjoy muffins in a healthy, enjoyable manner? In this recipe, renowned chef Pete Evans, who I partnered with in my upcoming Fat for Fuel Ketogenic Cookbook, shows you how to make muffins more interesting by using a calculated mix of meat, vegetables and spices. If youre just starting to adopt the ketogenic diet, this is the perfect dish because it combines healthy fats and protein in a delicious package.

 

Ingredients:

         1 1/3 pounds of free-range chicken thighs, minced

         5 free-range organic eggs

...

The Effects of Biodynamic Farming on the Environment and Food Quality Articles

By Dr. Mercola

Eating real, nonprocessed food is the key to sustaining good health, but even when it comes to whole food, its quality is largely determined by how it was grown. Certified organic food is recommended to avoid toxic contaminants such as pesticides. But even organic foods may be lacking in important nutrients if grown in nutrient-poor soils. To truly build good topsoil, you have to implement regenerative farming methods, many of which are not automatically required by organic standards.

Biodynamic certification, which is a step above organic, is the topic of todays discussion with Elizabeth Candelario, managing director for Demeter,1 a global Biodynamic certification agency. Candelario spent most of her career in the wine industry. While she was working as a marketing director for a winery in Sonoma County, the winery decided to transition from conventional to Biodynamic farming, which is how her interest in Biodynamics began.

Here in the United States, the wine industry was the early adopter in Biodynamic, Candelario says. The reason for that was really twofold. One is winemakers couldnt help but notice that the best wines in the world were coming from Biodynamic vineyards, wineries like Domaine de la Romane-Conti and Zind-Humbrecht. Another reason is that a lot of wineries, at least back in the day, were family-owned

You had winery families that were interested in passing that winery down from one generation to the next. The best example of that is the Frey Vineyards up in Mendocino County, where they literally have four generations of family living [there] They were really thinking about the ecological aspect of what they were doing and how they were farming. So, it wasnt unique that the winery I worked at chose [Biodynamic]

That experience I not only witnessed the transformation of the estate, but I also witnessed a transformation in the people we were working with was, for me, emerging between my career [in] the wine industry and my interest in social mission I joined Demeter about almost 10 years ago.

The History of Biodynamic Farming

Organic is well-known in the U.S. market. Biodynamic is a fairly unknown concept, although its history spans back nearly nine decades. Biodynamic farming is a spiritual-ethical-ecological appr...

07:47

Five MORE Things That Dont Add up About the Las Vegas Massacre REALfarmacy.com

Source: Five MORE Things That Dont Add up About the Las Vegas Massacre For more content like this visit REALfarmacy.com.

The media has released photos of guns and ammo magazines laying around on the floor of the supposed snipers nest hotel room on the 32nd floor of the Mandalay Bay hotel in Las Vegas, but theres something totally wrong with these pictures   #1) Where is all the expended brass? Now, maybe Im just a []

Source: Five MORE Things That Dont Add up About the Las Vegas Massacre Learn more at REALfarmacy.com - Healthy News and Information.

06:54

Survival Medicine Hour: Labor and Delivery, Wildfire, More Doom and Bloom (TM)

In any long-term survival situation involving a group or community, eventually the issue of pregnancy and childbirth arises. The medic for the group should know basics about pregnancy and childbirth. Childbirth is a natural process that usually doesnt require a doctor or even a midwife to manage, as long as some simple steps are followed. Joe and Amy Alton, aka Dr. Bones and Nurse Amy, take you through a typical labor and delivery process. Also, wildfires are raging through Northern

[... Continue Reading]

03:25

Flu Vaccines in Pregnancy and Childhood: What You Need to Know Natural Blaze

By The World Mercury Project Team

Download and print our flu vaccine brochure. Share with your family, friends, doctors and community leaders.

Visit our flu vaccine web page. Its full of flu facts to help you make informed decisions about your familys healthcare.

You want to do everything right for your child, and would never knowingly allow someone to inject a neurotoxin into your infant. Before getting a flu shot, you need to know this: MERCURY is a NEUROTOXIN.

What You Need to Know

The Food and Drug Administration (FDA) warns pregnant women and young children not to eat fish containing high levels of methylmercury. Yet the Centers for Disease Control and Prevention (CDC) recommends pregnant women and infants get influenza vaccines, many of which contain ethylmercury from the preservative thimerosal. Receiving them may result in mercury exposures exceeding the Environmental Protection Agency (EPA) recomm...

03:16

Researchers Accused Of Hiding Death Of Man Awakened From Coma After 15 Years Natural Blaze

 

The experimental nerve stimulation treatment restored minimal consciousness but the patient died shortly after of supposedly unrelated complications.

   SEE: Man Responds After 15 Year Vegetative State Following Nerve Implant

Earlier this year, French researchers reportedly restored consciousness in a man that had been in a coma for 15 years. According to the study, using an interesting experimental method of re-awakening, the previously unresponsive man regained minimal awareness. Researchers released the statement, Brain plasticity and brain repair are still possible even when hope seems to have vanished.

The researchers, from the French National Center for Scientific Research, used a practice known as vagus nerve stimulation (VNS) to awaken the 35-year-old man. The man, whose name has not been released, had been in vegetative state since his involvement in a car accident at age 20. The stimulation is performed by sending small electric shocks into the nerve. This practice has been used clinically for treatment-resistant depression and intractable epilepsy.

...

01:24

Weekend reads: Systemic fraud in China; science without journals; authorship rules decay Retraction Watch

The week at Retraction Watch featured the retraction of a paper that had been called anti-vaccine pseudoscience, a retraction following threats of violance against an editor, and an editorial board members resignation over how a journal handled a case of plagiarism. Heres what was happening elsewhere: Now, a recent string of high-profile scandals over questionable []

The post Weekend reads: Systemic fraud in China; science without journals; authorship rules decay appeared first on Retraction Watch.

00:57

Las Vegas Witness Who Identified Multiple Shooters, Found Dead REALfarmacy.com

Source: Las Vegas Witness Who Identified Multiple Shooters, Found Dead For more content like this visit REALfarmacy.com.

Kymberley Suchomel, a survivor of the Las Vegas shooting who claimed there were multiple gunmen involved in the shooting, has been found dead. She was 28. Suchomel was not injured during the shooting at the Route 91 music festival, and died suddenly in the early hours of Monday at her Apple Valley home, according to []

Source: Las Vegas Witness Who Identified Multiple Shooters, Found Dead Learn more at REALfarmacy.com - Healthy News and Information.

00:57

Calgary: Keep fluoride out of our tap water Fluoride Action Network

Re: The science is not settled on water fluoridation, Licia Corbella, Opinion, Oct. 12.

 As a medical doctor who has spent much of the past two decades studying all sides of the water fluoridation issue, I am elated to see someone in the media tackle this contentious issue so boldly and directly.

Licia Corbella succinctly points out how the media and medical/dental establishment have been misled and misrepresent the infamous U of C study.

The sad reality is that dental caries are increasing in Calgary and Edmonton, and that it has nothing to do with fluoridation.

There are well over 1,000 studies revealing potential harms from fluoridation. Over 4,000 professionals worldwide have had the courage to sign an open letter against fluoridation.

The dental health in 98 per cent unfluoridated Europe, Quebec and B.C. is as good or better than in 75 per cent fluoridated U.S.A. and Ontario.

Harms from fluoridation include, but are not limited to, the neurological system, thyroid, kidney and bone.

I cannot imagine an informed parent risking the mental wellbeing of their child to perhaps prevent one cavity over their lifetime.

Robert C. Dickson, MD, CCFP, FCFP, Calgary

*Original letter online at http://calgaryherald.com/opinion/letters/your-letters-for-saturday-oct-14

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Saturday, 14 October

21:03

Talking About Mental Health After Mass Shootings is a Cop-Out Mad In America

From The Washington Post: Blaming mass shootings on mental illness is a distortion of the facts and a convenient way to dodge a necessary conversation on gun control.

There is no evidence that the Las Vegas shooter was insane. (I prefer not to use his name and give him publicity, even posthumously.) He did not have a history of mental illness that we know of, nor had he been reported for behavior that would suggest any such condition. He was clearly an evil man, or at least a man who did something truly evil. But evil is not crazy. If we define the attempt to take an innocent human beings life as madness, then every murderer is mad. If not, we should recognize that it is a meaningless term that adds little to our understanding of the problem.

Article

21:02

Late Night Snack Shrink: Sarah Silverman Mad In America

In this video, comedian Sarah Silverman recounts her journey with mental health treatment and discusses how therapy has helped her.

21:01

Type 2 Diabetes and Antidepressant Use: Is There a Causal Link? Mad In America

From EndocrinologyAdvisor: A recent meta-analysis suggests that antidepressant drug use may increase patients risk of diabetes. According to the lead investigator, over 1 million diabetes cases could be due to concurrent antidepressant use.

Article

21:00

Don't Ask. Don't Tell. Just Make Sure Profits Stay Well. AGE OF AUTISM

By Anne Dachel Re: Harvey Weinstein story According to a number of stories in the news, Hollywood producer Harvey Weinstein spent over 3 decades groping and assaulting and paying off women, and no one knew what was going on until...

20:59

World Mercury Project on Mercury Laden Flu Vaccines AGE OF AUTISM

You want to do everything right for your child, and would never knowingly allow someone to inject a neurotoxin into your infant. Before getting a flu shot, you need to know this: MERCURY is a NEUROTOXIN. What You Need to...

20:36

Study deals blow to fluoridation Fluoride Action Network

Last month, Environmental Health Perspectives published an article titled Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years in Mexico.

The article is notable not only for its substance but also for the fact that the publication it appeared in has support from the National Institute of Environmental Health Sciences. NIEHS falls within the National Institutes of Health under the U.S. Department of Health and Human Services. Further, the study itself was supported by NIH, NIEHS and the U.S. Environmental Protection Agency, as well as the Ministry of Health in Mexico.

In a sense, the findings of the study are not new. They indicate the likelihood that exposure to fluoride above a certain level will lower the IQ of children. Numerous earlier studies have pointed in the same direction, raising warning flags for fluoride exposure through community water fluoridation and other sources.

What is especially notable is that you have an arm of the U.S. government putting forth a study that challenges a central public health policy of the U.S. Department of Health and Human Services. That policy is community water fluoridation.

While the NIEHS publication did not endorse the study, it saw fit to publish it. Thats significant inasmuch as promoters of fluoridation, like the American Dental Association, dismiss challenges to fluoridation as affronts to settled science.

You may ask how the fluoridation policy is challenged. How is a measure deemed by the Centers for Disease Control and Prevention to be one of the 10 great public health achievements of the 20th century undermined by this recent study? Heres how:

1. The fluoride exposures of the pregnant women in the study corresponded to exposures found in persons living in fluoridated communities.

2. The effect found was large. At a level of 0.9 parts per million in the mothers urine (which would be reached by many women in fluoridated communities), the associated IQ loss was 5 to 6 points. If such a drop were to occur in the whole population, it would more than halve the number of very bright children (IQ greater than 130) and increase by more than half the number of mentally handicapped (IQ less than 70).

3. The study demands respect. It is strong in controlling for confounding factors, that is, conditions that might affect IQ other than fluoride.

Publication of the Prenatal Fluoride study came close on the heels of the Sixth Annual Citizens Convention of the Fluoride Action Network in Crystal City, Virginia, from Sept. 15 to 18. The convention represented a number of states, four other countries, and the Akwesasne Territory within Canada and the United States.

Throughout our four-day gathering, we reviewed the developing science on fluoridation, the political fight and how it is best conducted, and the evidence that the fluoridation house of cards teeters ever closer to colla...

19:01

Olga Runciman: Moving Beyond Psychiatry Mad In America

This week on the Mad in America podcast we interview Olga Runciman. Olga is an international trainer and speaker, writer, campaigner, and artist. She co-founded the Danish Hearing Voices Network and sees the role of the Hearing Voices Movement as post-psychiatric, working towards the recognition of human rights while offering hope, empowerment, and access to making sense of individual experiences.

Olga was a psychiatric nurse working in social psychiatry but today she is a psychologist and since 2013 she has had her own private practice in Denmark, working with people who have been labelled schizophrenic or psychotic. Olga is herself a psychiatric survivor and a voice hearer too.

In this interview, we discuss Olgas professional and personal experiences of the psychiatric system and how she now helps and supports healing and recovery in others.

To subscribe to the Mad in America podcast in iTunes, click here.

In the episode we discuss:

  • How Olga became a specialist psychiatric nurse in Denmark, believing at the time the reasons given for psychiatric diagnoses.
  • How she came to see that there was little evidence or corroboration to underpin the diagnosis and treatment that she witnessed.
  • How Olga was also a voice hearer but kept this hidden from her psychiatric colleagues.
  • How, when experiencing stress and trauma, Olga came to be admitted to a psychiatric ward, diagnosed as schizophrenic and treated with a cocktail of psychiatric drugs.
  • Olgas experiences of the antipsychotic drug Clozapine.
  • How Olga came to stop her psychiatric drugs which she had been taking for ten years.
  • Psychiatrys story of hopelessness and chronic illness that is so often sold to patients.
  • How Olga now views her work from a post-psychiatry perspective.

Relevant links:

Psycovery

Olgas posts on Mad in America

The Hearing Voices network

International Institute for Psychiatric Drug Withdrawal

...

17:52

Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in mice. GreenMedInfo

PMID:  Mol Med Rep. 2017 Sep ;16(3):2844-2850. Epub 2017 Jun 30. PMID: 28677803 Abstract Title:  Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice. Abstract:  Diabetes is commonly associated with liver lipid metabolism disorders. AMP-activated protein kinase (AMPK) has a key role in regulating lipid metabolism. Grape seed procyanidin B2 (GSPB2), a natural polyphenol polymer, ameliorates mitochondrial dysfunction and inhibits oxidative stress or apoptosis via AMPK pathways. In the present study, the hypothesis that GSPB2 treatment may ameliorate liver lipid metabolic disorders by activating AMPK and downstream pathways was tested in diabetic mice. Db/m mice were used as controls, and diabetic db/db mice were randomly divided into 2 groups for treatment: Vehicle and GSPB2 (30 mg/kg/day for 10 weeks). Animals were weighed every week. Fasting blood was collected prior to sacrifice to measure fasting blood glucose (FBG), triglycerides (TG) and total cholesterol (TC). Hepatic TG and free fatty acid (FFA) levels were analyzed. Hepatic sections were examined by light microscopy following hematoxylin and eosin staining. The expression of hepatic AMPK, phosphorylated acetylCoA carboxylase (ACC), carnitine palmitoyl transferase 1 (CPT1) and 4hydroxynonenal (4HNE) was measured by western blot analysis. Liver mitochondria were isolated to assess electron transportcomplex I (CI), complex II (CII) and complex IV by high-resolution respirometry. The results demonstrated that GSPB2 significantly decreased body weight and serum TG, TC and FFA levels, but not FBG levels in diabetic mice. GSPB2 visibly decreased lipid droplet accumulation in the liver and significantly reduced hepatic TG and FFA levels. In diabetic mice, GSPB2 restored liver AMPK and ACC phosphorylation, increased CPT1 protein expression, ameliorated lipid peroxidation damage, which was assessed by comparing 4HNE levels, and partially restored the damaged mitochondrial respiratory capacity of CI and CII in the liver. In conclusion, longterm oral treatment with GSPB2 may benefit hepatic lipid metabolism disorders, potentially by decreasing hepatic lipid synthesis and increasing hepatic FFA oxidation via the AMPKACC pathway.

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17:47

Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2017 Nov 4 ;493(1):794-799. Epub 2017 Aug 24. PMID: 28844677 Abstract Title:  Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway. Abstract:  Prostatitis is one of the most prevalent problems in andriatry and urinary surgery. In the present study, we evaluated the effect of procyanidin B2 (PB) on carrageenan-induced chronic nonbacterial prostatitis in rats. Results showed that PB significantly decreased the prostatic index and enhanced the body weight inhibited by carrageenan. Biochemical results revealed that PB significantly lowered the prostatic specific antigen (PSA) and alleviated oxidative stress in serum. The levels of TNF-, IL-6, and IL-10 in prostatic homogenate were also significantly decreased after PB treatment. We also found evidence that PB treatment reversed the suppression of Nrf2 nuclear translocation, and increased the expressions of NQO1 and HO-1 in the prostate glands. In conclusion, treatment with PB attenuates carrageenan-induced chronic nonbacterial prostatitis via anti-inflammatory and activation of the Nrf2 pathway.

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17:42

Procyanidin B2 induces oxidative stress-mediated cell death in prostate cancer cells. GreenMedInfo

PMID:  Mol Carcinog. 2017 Sep 6. Epub 2017 Sep 6. PMID: 28876465 Abstract Title:  Procyanidin B2 3,3-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Abstract:  Neoplastic cells exhibit higher oxidative stress compared to normal cells; however, antioxidants based clinical trials have mostly failed. Another attractive therapeutic approach is to further increase the oxidative stress in cancer cells leading to cell death. Herein, we show that Procyanidin B2 3,3-di-O-gallate (B2G2), the most active constituent of grape seed extract, treatment causes cell death in human prostate cancer (PCa) cells (LNCaP and 22Rv1) via increasing the reactive oxygen species (ROS) generation. Mechanistically, B2G2 treatment decreased the mitochondrial electron transport chain complex III activity leading to enhanced mitochondrial superoxide generation and decreased ATP production in LNCaP cells. Additional molecular studies revealed that B2G2-induced cell death was mediated mainly through ROS-induced sustained activation of ERK1/2, which was due to inhibition of MAPkinase phosphatase (MKP) activity as over-expression of MKP3 in LNCaP cells conferred significant protection against B2G2-induced cell death. Along with ERK1/2, AMP-activated protein kinase (AMPK) was also activated by B2G2 treatment, and pre-treatment with AMPK inhibitor compound C significantly reversed the cytotoxic effects of B2G2 in LNCaP cells. Furthermore, pre-treatment of MKP3 over-expressing LNCaP cells with compound C further reduced the B2G2-induced cell death, suggesting the involvement of AMPK along with MKP3 and ERK1/2 in the biological effects of B2G2. Together, theseresults for the first time identified that oxidative stress and MKP3 inhibition play a critical role in B2G2-induced cell death in PCa cells through sustained activation of both ERK1/2 and AMPK. These results offer a unique opportunity to control this deadly malignancy through B2G2 use.

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17:37

Apple procyanidin B2 on keratin biosynthesis in vitro, and highlights its effect as a nutraceutical on human hair growth and tropism. GreenMedInfo

PMID:  J Med Food. 2017 Sep 28. Epub 2017 Sep 28. PMID: 28956697 Abstract Title:  Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial. Abstract:  Several pharmaceutical products have been formulated over the past decades for the treatment of male and female alopecia, and pattern baldness, but relatively few metadata on their efficacy have been published. For these reasons, the pharmaceutical and medical attention has recently focused on the discovery of new and safer remedies. Particularly, great interest has been attracted by oligomeric procyanidin bioactivity, able to promote hair epithelial cell growth as well as to induce the anagen phase. Specifically, the procyanidin B2, a dimeric derivative extracted from apples, has demonstrated to be one of the most effective and safest natural compounds in promoting hair growth, both in vitro and in humans by topical applications. By evaluating the polyphenolic content of different apple varieties, we have recently found in the apple fruits of cv Annurca (AFA), native to Southern Italy, one of the highest contents of oligomeric procyanidins, and, specifically, of procyanidin B2. Thus, in the present work we explored the in vitro bioactivity of AFA polyphenolic extract as a nutraceutical formulation, named AppleMets (AMS), highlighting its effects on the cellular keratin expression in a human experimental model of adult skin. Successively, testing the effects of AMS on hair growth and tropism in healthy subjects, we observed significant results in terms of increased hair growth, density, and keratin content, already after 2 months. This study proves for the first time the impact of apple procyanidin B2 on keratin biosynthesis in vitro, and highlights its effect as a nutraceutical on human hair growth and tropism.

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17:28

Polysaccharides from Inonotus obliquus might be a promising functional food or drug candidate for diabetes treatment. GreenMedInfo

PMID:  Biomed Pharmacother. 2017 Sep 23 ;95:1669-1677. Epub 2017 Sep 23. PMID: 28954386 Abstract Title:  Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway. Abstract:  Polysaccharides are the main components of mushroom Inonotus obliquus (I. obliquus) with antihyperglycemic activities. This study was aimed to investigate the anti-diabetic effects and the potential mechanism of I. obliquus polysaccharides (IOPS) in high fat diet and STZ-induced type 2 diabetic mice. Results showed that oral administration of IOPS (900mg/kg) could significantly restore the body and fat mass weight, reduce fasting blood glucose levels, improve glucose tolerance ability, increase hepatic glycogen level and ameliorate insulin resistance compared to those of the control diabetic mice (P

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17:06

Natural compounds from Cortex Phellodendri and Humulus japonicus had anti-inflammatory effects on pelvic inflammatory disease. GreenMedInfo

PMID:  Int J Med Sci. 2017 ;14(8):729-734. Epub 2017 Jul 18. PMID: 28824307 Abstract Title:  Anti-inflammatory Effects of the Natural Compounds Cortex Phellodendri and Humulus japonicus on Pelvic Inflammatory Disease in Mice. Abstract:  Pelvic inflammatory disease (PID) is an inflammatory and/or infectious disorder of the upper female genital tract, including the uterus, fallopian tubes, and adjacent pelvic structures, that may spread upward to the peritoneum. Currently available treatment options have presented to produce adverse effects of various degrees, such as increased antimicrobial resistance and a limited effective duration of hormones. In the study, the Cortex Phellodendri (CP) and Humulus japonicus (HJ) among natural compounds that are believed to present biological activities with fewer side effects were tested in a PID animal model. The results suggested that the administration CP and HJ reduced clinical signs, inflammatory cytokine expression as well as secretion in uterine tissue, and neutrophil infiltration into the tissue.

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16:56

These findings suggest xanthohumol as a promising new strategy for preventing diabetic osteopathy. GreenMedInfo

PMID:  J Appl Toxicol. 2017 Sep 20. Epub 2017 Sep 20. PMID: 28940469 Abstract Title:  Cytoprotective effects of xanthohumol against methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblastic cells. Abstract:  Methylglyoxal (MG) has been suggested to be a major source of intracellular reactive carbonyl compounds, and has been implicated in increasing the levels of advanced glycation end products in age-related diseases. Xanthohumol is a prenylated flavonoid found in hops (Humulus lupulus) and beer. In the present study, we investigated the effects of xanthohumol on MG-induced cytotoxicity in osteoblastic MC3T3-E1 cells. Xanthohumol attenuated MG-induced cytotoxicity, as evidenced by improved cell viability, and prevented MG-induced MG-protein adducts, inflammatory cytokines, reactive oxygen species and mitochondrial superoxide production. In addition, xanthohumol increased glyoxalase I activity, glutathione, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 levels in the presence of MG. Pretreatment with xanthohumol before MG exposure reduced MG-induced mitochondrial dysfunction. Furthermore, xanthohumol treatment resulted in a significant reduction in the levels of endoplasmic reticulum stress and autophagy induced by MG. Notably, the autophagy-reducing effect of xanthohumol was abolished after the addition of Ex527, a selective inhibitor of sirtuin 1, suggesting that xanthohumol is an effective sirtuin 1 activator for reducing autophagy. Taken together, our findings suggest xanthohumol as a promising new strategy for preventing diabetic osteopathy.

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16:50

An ethanol extracts of Humulus lupulus could partially prevent ovariectomy-induced bone loss. GreenMedInfo

PMID:  Phytomedicine. 2017 Oct 15 ;34:50-58. Epub 2017 Aug 2. PMID: 28899509 Abstract Title:  A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus. Abstract:  BACKGROUND: Hops (Humulus lupulus (L.)) dietary supplements are of interest as herbal remedies to alleviate menopausal symptoms, such as hot flushes, depression and anxiety. So far, the evidence regarding estrogenic and related properties of hops preparations has been considered insufficient for a market authorization for menopausal indications.PURPOSE: The study aims to investigate a chemically standardized hops extract regarding its safety in the uterus, as wells as its efficacy to prevent bone loss in the ovariectomized rat model.STUDY DESIGN/METHODS: Female Wistar rats were ovariectomized and divided into a control group receiving phytoestrogen-free diet, a group treated with E2benzoate (0.93mg/kg body weight/d) and a group treated with the standardized hops extract (60mg/kg body weight/d) for 8 weeks. Micro-computed tomography of the tibiae and vertebrae, as wells as histological changes in the uterus and tibia were analyzed.RESULTS: Neither uterotrophic nor proliferative effects were observed in the endometrium in response to the oral 8-week administration of the hops extract. However, site-dependent skeletal effects were observed. The hops extract significantly decreased the number of osteoclasts in the tibial metaphysis and prevented reduction of the trabecular thickness that resulted from estradiol depletion. In contrast, the hops extract did not prevent the ovariectomy-induced micro-architectural changes in the lumbar vertebra. Certain parameters (e.g. thickness and number of trabeculae) were even found to be below the values determined in the ovariectomized control group.CONCLUSION: Taken together, the results provide evidence for the safety of the standardized hops extract and point to a weak bone type-specific, protective effect on bone loss following estradiol depletion.

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16:40

Xanthohumol treatment modulated the inflammation and apoptosis of aged brains, exerting a protective effect on damage induced by aging. GreenMedInfo

PMID:  J Nutr Biochem. 2017 Jul 27 ;49:133-140. Epub 2017 Jul 27. PMID: 28950154 Abstract Title:  Protective effect of xanthohumol against age-related brain damage. Abstract:  It has been recently shown that xanthohumol, a flavonoid present in hops, possesses antioxidant, anti-inflammatory and chemopreventive properties. However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective activity of xanthohumol against age-related inflammatory and apoptotic brain damage in male senescence-accelerated prone mice (SAMP8). Animals were divided into 4 groups: Untreated young mice, untreated old mice and old mice treated either with 1 mg kg(-1) day(-1) or 5 mg kg(-1) day(-1) xanthohumol. Young and old senescence accelerated resistant mice (SAMR1) were used as controls. After 30 days of treatment, animals were sacrificed and their brains were collected and immediately frozen in liquid nitrogen. mRNA (GFAP, TNF-, IL-1, AIF, BAD, BAX, XIAP, NAIP and Bcl-2) and protein (GFAP, TNF-, IL-1, AIF, BAD, BAX, BDNF, synaptophysin and synapsin) expressions were measured by RT-PCR and Western blotting, respectively. Significant increased levels of pro-inflammatory (TNF-, IL-1) and pro-apoptotic (AIF, BAD,BAX) markers were observed in both SAMP8 and SAMR1 old mice compared to young animals (P

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16:00

Fluoride: Poison on Tap Articles

By Dr. Mercola

Today, 74 percent of Americans on community water systems receive fluoridated water.1 Since 1945, it has been widely accepted in the U.S. that fluoride is "safe and effective" to prevent tooth decay. But is it really?

The 2015 documentary, "Fluoride: Poison on Tap," seeks to expose what may be one of the longest-running and most successful deceptions known to mankind adding industrial waste, in the form of fluoride, to public drinking water. You may be shocked at the lengths to which corporations, industry and government have gone to make this industrial waste product appear beneficial to your health.

Fluoride = Health: How Did We Get Here?

You may be surprised to know the first American commercial use of fluoride, in the form of sodium fluoride, was to kill insects, lice, mice and other vermin. It was quite effective. In the 1930s, aluminum-industry giant Alcoa was the largest producer of fluoride, releasing vapors into the atmosphere that crippled or killed farm animals and scorched crops and other vegetation. In those early years, many lawsuits were brought against Alcoa to recover damages from lost animals and crops.

Growing concerns about the seemingly negative effects of fluoride gas on human beings motivated the company to devise a means of recycling this potent industrial byproduct. The brainchild of water fluoridation was Gerald Cox, a researcher with the Mellon Institute in Pittsburgh. He received a request to look at fluoride's effects on teeth from Alcoa lab director Francis Frary, who was concerned about mounting lawsuits related to the fluoride pollution his plant produced.

Another motivation was the reality that disposing of fluoride waste from its aluminum plants was becoming increasingly costly for Alcoa. Previously, the Mellon Institute had been the leading defender of the asbestos industry, producing research showing asbestos was harmless and worker health problems were purportedly due to other causes. Using "science" as a smokescreen, the Mellon Institute was able to save the asbestos industry from financial catastrophe.

As a result of their success in using science to prop up the asbestos industry at that time, it makes sense Alcoa chose Cox and the Mellon Institute to craft a story around the perceived health benefits of fluoride. To ensure their success, Alcoa executives realized public opinion about fluoride had to be carefully and continuously manipulated.

In a bold move, they hired public-relations pioneer Edward Bernays, who later became known...

How Long Should You Wash Your Hands? Articles

By Dr. Mercola

Handwashing is one of the top strategies you can use to prevent the spread of colds, flu, salmonella and other germs that cause illness. The key to this technique is to do it correctly and for the proper amount of time. Several studies have evaluated compliance with handwashing in the general public and health care facilities. You may be surprised by the results.

In a study from Michigan State University,1 researchers watched more than 3,700 people after using the bathroom and reported that 95 percent did not wash their hands long enough to kill germs.2

The average amount of time people spent washing was only six seconds. Even more disturbing was that 7 percent of women and 15 percent of men didn't wash their hands at all. A recent study of 2,000 people from Britain found similar results after using the bathroom, as 84 percent were not washing their hands long enough to reduce the spread of infection.3

Poor hand hygiene is also an issue in health care. According to the Centers for Disease Control and Prevention (CDC), health care providers wash their hands less than half the time that they should.4 The World Health Organization (WHO) estimates only an average of 40 percent of providers wash their hands when appropriate. Passing germs from patient to provider to patient,5 and poor patient handwashing, may be reasons an estimated 1 in every 4 patients who leave the hospital will have a superbug on their hands.6

Handwashing Is Your First Line of Defense Against Germs

Proper handwashing that removes microbes and viruses from your hands is one of the single most important ways of reducing the spread of infection.7 You can infect yourself when you touch your mouth, eyes and nose with fingers contaminated with bacteria, and you may spread those germs to others when you touch them or an inanimate object that they then touch.

A new study released by the British Royal Pharmaceutical Society found that washing your hands for just 20 seconds8 will remove germs and reduce the need for antibiotics.9

...

15:59

Geoengineering Watch Global Alert News, October 14, 2017 Geoengineering Watch

998u7Dane Wigington GeoengineeringWatch.org From record hurricanes to public massacres to unprecedented firestorms, each new catastrophe is providing cover for the power structure while they continue to prepare for collapse. Each new catastrophe helps to eclipse the former disasters from the publics consciousness. More and more of the population is starting to suspect that there is more to

15:50

Purified hop compounds could have use as alternatives for treatment of infections caused by select anaerobic bacteria. GreenMedInfo

PMID:  APMIS. 2017 Sep 28. Epub 2017 Sep 28. PMID: 28960474 Abstract Title:  Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria. Abstract:  Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C. difficile infection is problematic, making it imperative to search for new compounds with antimicrobial properties. Hops (Humulus lupulus L.) contain substances with antibacterial properties. We tested antimicrobial activity of purified hop constituents humulone, lupulone and xanthohumol against anaerobic bacteria. The antimicrobial activity was established against B. fragilis, C. perfringens and C. difficile strains according to standard testing protocols (CLSI, EUCAST), and the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were calculated. All C. difficile strains were toxigenic and clinically relevant, as they were isolated from patients with diarrhoea. Strongest antimicrobial effects were observed with xanthohumol showing MIC and MBC values of 15-107 g/mL, which are close to those of conventional antibiotics in the strains of bacteriawith increased resistance. Slightly higher MIC and MBC values were obtained with lupulone followed by higher values of humulone. Our study, thus, shows a potential of purified hop compounds, especially xanthohumol, as alternatives for treatment of infections caused by select anaerobic bacteria, namely nosocomial diarrhoea caused by resistant strains.

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15:34

Nobiletin may offer a therapeutic benefit and could potentially be used as a vasodilator for the treatment of hypertension. GreenMedInfo

PMID:  J Vasc Res. 2016 ;53(5-6):330-339. Epub 2016 Dec 17. PMID: 27988519 Abstract Title:  Nobiletin Relaxes Isolated Mesenteric Arteries by Activating the Endothelial Ca2+-eNOS Pathway in Rats. Abstract:  AIMS: Nobiletin, a natural polymethoxylated flavonoid compound, has various beneficial properties, such as anticancer, anti-inflammatory, and antioxidant effects, and it also improves memory. Therefore, we investigated the effects and mechanisms of nobiletin on rat isolated mesenteric arteries (MAs).METHODS: We examined vasodilation induced by nobiletin on rat isolated MA rings with a tension study, the expression and activity of endothelial nitric oxide synthase (eNOS) with Western blotting, NO production with DAF- FMDA fluorescence, and intracellular Ca2+ concentration ([Ca2+]i) with Fluo-3AM.RESULTS AND CONCLUSION: Our study showed that nobiletin elicited a dose-dependent vasodilation in phenylephrine precontracted MA rings, but it did not elicit the same response in pulmonary artery rings. Vasodilation was related to endothelium and activated partly by eNOS. Vasodilation was inhibited by denudation of the endothelium or inhibition of eNOS activity. Nobiletin increased NO production by promoting the phosphorylation of eNOS at Ser-1177 without changing the level of eNOS expression in rat mesenteric artery endothelial cells (RMAECs). Nobiletin increased the concentration of endothelial [Ca2+]i, which enhances eNOS activity in RMAECs. In summary, vasodilation induced by nobiletin was dependent on the endothelium and partly on eNOS activation, which is mediated by high endothelial [Ca2+]i. Results suggest nobiletin may offer a therapeutic benefit and could potentially be used as a vasodilator for the treatment of hypertension.

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15:30

These data suggest that nobiletin might be a potential antithrombotic agent of dietary origin. GreenMedInfo

PMID:  Biochem Pharmacol. 2017 Mar 15 ;128:26-33. Epub 2016 Dec 23. PMID: 28017776 Abstract Title:  Nobiletin inhibits oxidized-LDL mediated expression of Tissue Factor in human endothelial cells through inhibition of NF-B. Abstract:  INTRODUCTION: Flavonoids are nutrients usually included in human diet with several significant biological activities. Nobiletin is a flavonoid that, besides having anti-inflammatory and anti-tumoral activity, seems to exert protective effects on cardiovascular system. Several studies investigated nobiletin as a natural drug to antagonize the atherosclerotic disease. On the contrary, literature about its potential role in modulating the main acute complication of atherosclerosis, thrombosis, is still scanty. Several studies have indicated that Tissue Factor (TF) plays a pivotal role in the pathophysiology of cardiovascular thrombotic events by triggering the formation of intracoronary thrombi. Oxidized-LDL have an important role in promoting athero-thrombotic events. This study investigates whether nobiletin might exert protective cardiovascular effects by preventing the oxidized-LDL mediated expression of TF in human endothelial cells in vitro. Moreover, we have studied whether the nobiletin effects might be modulated by the inhibition of the NF-B pathway.METHODS AND RESULTS: In HUVEC, ox-LDL induced TF-mRNA transcription as demonstrated by real time PCR and expression of functionally active TF as demonstrated by Western-blot, FACS analysis and pro-coagulant activity assay. Nobiletin prevented these ox-LDL-mediated effects by exerting antioxidant effects, finally leading to inhibition of the transcription factor NF-B.CONCLUSIONS: These data suggest that nobiletin might be a potential antithrombotic agent of dietary origin. This flavonoid, through its antioxidant proprieties, might potentially exert an antithrombotic activity by inhibiting TF expression/activity in a cell population never investigated before in this context and that is normally represented in vessel wall such as endothelial cells.

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15:20

Nobiletin can ameliorate ischemia-reperfusion injury after liver transplantation. GreenMedInfo

PMID:  Biomed Pharmacother. 2017 May ;89:732-741. Epub 2017 Mar 6. PMID: 28273635 Abstract Title:  Nobiletin ameliorates ischemia-reperfusion injury by suppressing the function of Kupffer cells after liver transplantation in rats. Abstract:  This study aims to explore the protective effects of nobiletin against hepatic ischemia-reperfusion (IR) injury after liver transplantation. Kupffer cells (KCs) were activated and co-cultured with different concentration of nobiletin for 24h in vitro, inflammatory products and activity of TLR4/NF-B signaling pathway were detected. Sprague-Dawley rats were selected and underwent orthotopic liver transplantation. Donors were injected intravenously with nobiletin (50mg/kg) or saline solution, once a day for 1 week before the surgery. Recipients were randomly paired and sacrificed at the indicated time points (3, 6, and 24h after the surgery), the graft liver tissues and blood samples were collected for analysis. Hepatic function, inflammatory mediators, apoptosis of hepatocytes, histological changes, KCs and CD4+ T-lymphocyte infiltration were assessed. Results showed nobiletin dose-dependently suppressed the expression of inflammatory mediators and the activity of TLR4/NF-B signaling pathway in activated KCs. Furthermore, nobiletin alleviated liver damage induced by IR in vivo, significantly decreased the serum levels of alanine aminotransferase, aspartate transaminase, inflammatory cytokines and alleviated the histopathology changes. Moreover, liver in the nobiletin treated group exhibited less KCs and CD4+ lymphocyte infiltration and lower hepatocyte apoptosis after operation. In addition, activity of TLR4/NF-B signaling pathway in KCs was also suppressed, consistentwith the results in vitro. Collectively, Nobiletin can ameliorate IR injury after liver transplantation and may be a promising new strategy to protect against liver IR injury.

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15:12

Nobiletin may have potential for the prevention of obesity-related metabolic diseases. GreenMedInfo

PMID:  J Med Food. 2017 Sep ;20(9):873-881. PMID: 28892456 Abstract Title:  Nobiletin Attenuates the Inflammatory Response Through Heme Oxygenase-1 Induction in the Crosstalk Between Adipocytes and Macrophages. Abstract:  Crosstalk between adipocytes and macrophages has been suggested to play a crucial role in metabolic disorders such as obesity, insulin resistance, and type 2 diabetes. The objective of this study was to evaluate the effect of nobiletin on the interaction between adipocytes and macrophages. The results showed that nobiletin significantly and dose-dependently inhibited the secretion of inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-), and monocyte chemoattractant protein (MCP)-1, in a coculture of adipocytes and macrophages. The expression of adipogenic transcription factors, including peroxisome proliferator-activated receptor gamma (PPAR) and CCAAT/enhancer-binding protein (C/EBP), in differentiated 3T3-L1 cells cocultured in transwell system was blocked by nobiletin. Nobiletin also downregulated the expression of inducible NO synthase in cocultured differentiated RAW264.7 cells. Furthermore, heme oxygenase-1 (HO-1) was significantly induced by nobiletin treatment in both cell types, and small interfering (si)RNA-mediated knockdown of HO-1 significantly recovered the inhibitory effects of nobiletin on the NO production in cocultured cells. These results suggest that nobiletin exerts anti-inflammatory effects on the crosstalk between adipocytes and macrophages by inducing HO-1. Nobiletin may have potential for the prevention of obesity-related metabolic diseases.

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14:42

Nobiletin has gastroprotective effects against ethanol-induced acute gastric lesions. GreenMedInfo

PMID:  Immunopharmacol Immunotoxicol. 2017 Sep 26:1-10. Epub 2017 Sep 26. PMID: 28948855 Abstract Title:  The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation. Abstract:  CONTEXT: Gastric ulcer is a common gastrointestinal disorder with increasing incidence and prevalence attributed to loss of balance between aggressive and protective factors. Nobiletin (NOB), a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-tumor activities. Although NOB was originally shown to possess anti-inflammatory activity, its effects on gastric ulcer were rarely explored previously.OBJECTIVE: The aim of the present study was to investigate the anti-ulcerogenic activity of NOB on ethanol-induced gastric ulcer in mice and to elucidate the underlying mechanisms.METHODS: Seventy-two male Kunming mice administered with absolute ethanol (0.2ml/animal) were pretreated with NOB (5, 10 or 20mg/kg), cimetidine (100mg/kg), or vehicles by intragastric administration in different experimental groups for three days, and animals were euthanized 3h after ethanol ingestion. Gross and microscopic lesions, immunological and biochemicalparameters were taken into consideration.RESULTS: The results showed that ethanol induced gastric injury, increased malondialdehyde (MDA) levels, decreased glutathione (GSH) content, superoxide dismutase (SOD) activity, and prostaglandin E2 (PGE2) levels, increased pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) levels and myeloperoxidase (MPO) activity, as well as the expression MAPK signaling pathway. Pretreatment with NOB significantly attenuated the gastric lesions as compared to the ethanol group.CONCLUSIONS: These findings suggest that the gastroprotective activity is attribute to the improvement of antioxidant activities, the stimulation of PGE2, and the reduction of pro-inflammatory cytokines through the MAPK pathway.

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14:37

These findings demonstrate a potential therapeutic value of combined application of berberine and PARP inhibitors in ovarian cancer treatment. GreenMedInfo

PMID:  Cell Death Dis. 2017 Oct 5 ;8(10):e3070. Epub 2017 Oct 5. PMID: 28981112 Abstract Title:  Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition. Abstract:  Many cancer drugs exert their therapeutic effect by inducing oxidative stress in the cancer cells. Oxidative stress compromises cell survival by inflicting lesions in macromolecules like DNA. Cancer cells rely on enhanced antioxidant metabolism and increased DNA repair function to survive oxidative assault. PARP1, a protein that senses DNA-strand breaks and orchestrates their repair, has an important role in the repair of oxidative DNA damage. Berberine, an alkaloid compound present in many herbal plants, is capable of inducing oxidative DNA damage and downregulating homologous recombination repair (HRR) in cancer cells. In this study, we demonstrated that berberine and PARP inhibitor niraparib have a synthetic lethal effect on ovarian cancer cells. Oxidative DNA damage was greatly induced by berberine in ovarian cancer cells. In addition, the level of RAD51 and the capacity of HRR were also reduced by berberine. Correspondingly, PARP became hyperactivated in response to berberine treatment. Cancer cells treated with berberine and niraparib in combination exhibited greatly increased apoptosis and remarkably reduced tumor growth in vivo. Together, the results indicate that by inducing oxidative DNA damage and downregulating HRR in cancer cells berberine is able to further sensitize cancer cells to PARP inhibition. Our findings demonstrate a potential therapeutic value of combined application of berberine and PARP inhibitors in ovarian cancer treatment.

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14:23

Nutraceuticals may enhance other anti-cancer drugs to suppress proliferation of cancer cells. GreenMedInfo

PMID:  Adv Biol Regul. 2017 Oct 3. Epub 2017 Oct 3. PMID: 28988970 Abstract Title:  Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells-Power of nutraceuticals. Abstract:  Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are consumed often by different cultures in various parts of the world, has become apparent. These"healthy"components of our diet are often referred to as nutraceuticals and they can prevent/suppress: aging, bacterial, fungal and viral infections, diabetes, inflammation, metabolic disorders and cardiovascular diseases and have other health-enhancing effects. Moreover, they are now often being investigated because of their anti-cancer properties/potentials. Understanding the effects of various natural products on cancer cells may enhance their usage as anti-proliferative agents which may be beneficial for many health problems. In this manuscript, we discuss and demonstrate how certain nutraceuticals may enhance other anti-cancer drugs to suppress proliferation of cancer cells.

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14:13

Berberine could inhibit the chemotherapy-induced repopulation of ovarian cancer cells. GreenMedInfo

PMID:  Cell Prolif. 2017 Oct 8. Epub 2017 Oct 8. PMID: 28990249 Abstract Title:  Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer. Abstract:  OBJECTIVES: Cytotoxic chemotherapy is an effective and traditional treatment of ovarian cancer. However, chemotherapy-induced apoptosis may also trigger and ultimately accelerate the repopulation of the small number of adjacent surviving cells. This study mainly focused on the tumour cell repopulation caused by chemotherapy in ovarian cancer and the adjunctive/synergistic effect of Berberine on the prevention of tumour repopulation.MATERIALS AND METHODS: The transwell system was used to mimic the co-culture of surviving ovarian cancer cells in the microenvironment of cytotoxic chemotherapy-treated dying cells. Tumour cell proliferation was observed by crystal violet staining. AA and PGE2 levels were measured by ELISA, and changes of protein expression were analysed by Western blot.RESULTS: Chemotherapy drug VP16 treatment triggered AA pathway, leading to the elevated PGE2 level, and ultimately enhanced the repopulation of ovarian cancer cells. Berberine can block the caspase 3-iPLA2 -AA-COX-2-PGE2 pathway by inhibiting the expression of iPLA2 and COX-2. Berberine can also reverse the increased phosphorylation of FAK caused by abnormal PGE2 level and thus reverse the repopulation of ovarian cancer cells after VP16 treatment.CONCLUSIONS: Our observation suggested that Berberine could inhibit the chemotherapy-induced repopulation of ovarian cancer cells by suppressing the AA pathway and phosphorylation of FAK. And these findings implicated a novel combined use of Berberine and chemotherapeutics, which might prevent ovarian cancer recurrence by abrogating early tumour repopulation.

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14:04

Blueberry could be used as a potential radiosensitizer to treat cervical cancer. GreenMedInfo

PMID:  Pathol Oncol Res. 2017 Sep 30. Epub 2017 Sep 30. PMID: 28963664 Abstract Title:  Blueberry as a Potential Radiosensitizer for Treating Cervical Cancer. Abstract:  Cervical cancer (CC) is a leading cause of death in women worldwide. Radiation therapy (RT) for CC is an effective alternative, but its toxicity remains challenging. Blueberry is amongst the most commonly consumed berries in the United States. We previously showed that resveratrol, a compound in red grapes, can be used as a radiosensitizer for prostate cancer. In this study, we found that the percentage of colonies, PCNA expression level and the OD value of cells from the CC cell line SiHa were all decreased in RT/Blueberry Extract (BE) group when compared to those in the RT alone group. Furthermore, TUNEL+ cells and the relative caspase-3 activity in the CC cells were increased in the RT/BE group compared to those in the RT alone group. The anti-proliferative effect of RT/BE on cancer cells correlated with downregulation of pro-proliferative molecules cyclin D and cyclin E. The pro-apoptotic effect of RT/BE correlated with upregulation of the pro-apoptotic molecule TRAIL. Thus, BE sensitizes SiHa cells to RT by inhibition of proliferation and promotion of apoptosis, suggesting that blueberry might be used as a potential radiosensitizer to treat CC.

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14:02

DTaP Vaccine Shatters UFC Fighters Family After It Kills Their Healthy Boy REALfarmacy.com

Source: DTaP Vaccine Shatters UFC Fighters Family After It Kills Their Healthy Boy For more content like this visit REALfarmacy.com.

by  Lyn Fattorini On Thursday May 11, 2017, UFC fighter Nick Catone tucked his healthy, beautiful little boy, Nicholas, into his crib to the sound of him saying, Goodnight Daddy. In the morning, Marjorie Catone went to wake the baby. And, in that moment, everything shattered. Twenty-month old Nicholas was gone. Marjorie says, My husband []

Source: DTaP Vaccine Shatters UFC Fighters Family After It Kills Their Healthy Boy Learn more at REALfarmacy.com - Healthy News and Information.

13:50

Anthocyanin rich extract of red cabbage alleviates experimentally induced myocardial infarction. GreenMedInfo

PMID:  PLoS One. 2017 ;12(8):e0182137. Epub 2017 Aug 1. PMID: 28763488 Abstract Title:  Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction. Abstract:  Cardioprotective potential of anthocyanin rich red cabbage extract (ARCE) was assessed in H2O2 treated rat neonatal cardiomyoblasts (H9c2 cells) and isoproterenol (ISO) induced rodent model of myocardial infarction. H2O2 treated H9c2 cells recorded cytotoxicity (48-50%) and apoptosis (57.3%), the same were reduced in presence of ARCE (7-10%&12.3% respectively). Rats pretreated with ARCE for 30 days followed by ISO treatment recorded favourable heart: body weight ratio as compared to ISO treated group. Also, the mRNA levels of enzymatic antioxidants (sod and catalase) and apoptotic genes (bax and bcl-2) in ARCE+ISO treated group were similar to the control group suggesting that ARCE pretreatment prevents ISO induced depletion of enzymatic antioxidants and apoptosis. Histoarchitecture of ventricular tissue of ISO treated group was marked by infracted areas (10%) and derangement of myocardium whereas, ARCE+ISO treated group (4.5%) recorded results comparable to control (0%). ARCE+ISO treated group accounted for upregulation of caveolin-3 and SERCA2a expression as compared to the ISO treated group implying towards ARCE mediated reduction in membrane damage and calcium imbalance. Molecular docking scores and LigPlot analysis of cyanidin-3-glucoside (-8.7 Kcal/mol) and delphinidin-3-glucoside (-8.5 Kcal/mol) showed stable hydrophobic and electrostatic interactions with1 adrenergic receptor. Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage.

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13:39

These results suggest the therapeutic potential of fucoidan for enhancing bone repair. GreenMedInfo

PMID:  J Tissue Eng Regen Med. 2017 Jul 16. Epub 2017 Jul 16. PMID: 28714275 Abstract Title:  Fucoidan-induced osteogenic differentiation promotes angiogenesis by inducing vascular endothelial growth factor secretion and accelerates bone repair. Abstract:  Osteogenesis and angiogenesis, including cell-cell communication between blood vessel cells and bone cells, are essential for bone repair. Fucoidan is a chemical compound that has a variety of biological activities. It stimulates osteoblast differentiation in human mesenchymal stem cells (MSCs), which in turn induces angiogenesis. However, the mechanism by which this communication between osteoblasts and endothelial cells is mediated remains unclear. Thus, the aim of this study was to clarify the relationship between fucoidan-induced osteoblastic differentiation in MSCs and angiogenesis in endothelial cells. First, the effect was confirmed of fucoidan on osteoblast differentiation in MSCs and obtained conditioned media from these cells (Fucoidan-MSC-CM). Next, the angiogenic activity of Fucoidan-MSC-CM was investigated and it was found that it stimulated angiogenesis, demonstrated by proliferation, tube formation, migration and sprout capillary formation in human umbilical vein endothelial cells. Messenger ribonucleic acid expression and protein secretion of vascular endothelial growth factor (VEGF) were dramatically increased during fucoidan-induced osteoblast differentiation and that its angiogenic activities were reduced by a VEGF/VEGF receptor-specific binding inhibitor. Furthermore, Fucoidan-MSC-CM increased the phosphorylation of mitogen-activated protein kinase and PI3K/AKT/eNOS signalling pathway, and that its angiogenic effects were markedly suppressed by SB203580 and AKT 1/2 inhibitor. Finally, an in vivo study was conducted and it was found that fucoidan accelerated new blood vessel formation and partially promoted bone formation in a rabbit model of a calvarial bone defect. This is the first study to investigate the angiogenic effect of fucoidan-induced osteoblastic differentiation through VEGF secretion, suggesting the therapeutic potential of fucoidan for enhancing bone repair.

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13:34

Las Vegas Shooting Victim: There Was 100% More Than One Shooter, Gates To Concert Were Locked Shortly Before Attack REALfarmacy.com

Source: Las Vegas Shooting Victim: There Was 100% More Than One Shooter, Gates To Concert Were Locked Shortly Before Attack For more content like this visit REALfarmacy.com.

By Alex Thomas Las Vegas mass shooting victim Rocky Palermo was shot in the pelvis during the horrific attack and is now speaking out about what he saw and believes happened, including the presence of multiple shooters as well as locked concert gates and police telling frantic civilians to go in the other direction. Palermo, []

Source: Las Vegas Shooting Victim: There Was 100% More Than One Shooter, Gates To Concert Were Locked Shortly Before Attack Learn more at REALfarmacy.com - Healthy News and Information.

13:33

Fucoidan could dose-dependently inhibit cell viability and proliferation of DU-145 cells. GreenMedInfo

PMID:  BMC Complement Altern Med. 2017 Aug 1 ;17(1):378. Epub 2017 Aug 1. PMID: 28764703 Abstract Title:  Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: possible JAK-STAT3 pathway. Abstract:  BACKGROUND: Prostate cancer is the most common cancer in men in the United States. Fucoidan is a bioactive polysaccharide extracted mainly from algae. The aim of this study was to investigate anti-tumor and anti-angiogenic effects of fucoidan in both cell-based assays and mouse xenograft model, as well as to clarify possible role of JAK-STAT3 pathway in the protection.METHODS: DU-145 human prostate cancer cells were treated with 100-1000 g/mL of fucoidan. Cell viability, proliferation, migration and tube formation were studied using MTT, EdU, Transwell and Matrigel assays, respectively. Athymic nude mice were subcutaneously injected with DU-145 cells to induce xenograft model, and treated by oral gavage with 20 mg/kg of fucoidan for 28 days. Tumor volume and weight were recorded. Vascular density in tumor tissue was determined by hemoglobin assay and endothelium biomarker analysis. Protein expression and phosphorylation of JAK and STAT3 were determined by Western blot. Activation of gene promoters was investigated by chromatin Immunoprecipitation.RESULTS: Fucoidan could dose-dependently inhibit cell viability and proliferation of DU-145 cells. Besides, fucoidan also inhibited cell migration in Transwell and tube formation in Matrigel. In animal study, 28-day treatment of fucoidan significantly hindered the tumor growth and inhibited angiogenesis, with decreased hemoglobin content and reduced mRNA expression of CD31 and CD105 in tumor tissue. Furthermore, phosphorylated JAK and STAT3 in tumor tissue were both reduced after fucoidan treatment, and promoter activation of STAT3-regulated genes, such as VEGF, Bcl-xL and Cyclin D1, was also significantly reduced after treatment.CONCLUSIONS: All these findings provided novel complementary and alternative strategies to treat prostate cancer.

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13:26

Mangifera indica leaves extract showed significant cholesterol lowering activity in high cholesterol diet induced hypercholesterolaemia model. GreenMedInfo

PMID:  Pharmacognosy Res. 2017 Jan-Mar;9(1):21-26. PMID: 28250649 Abstract Title:  Evaluation of Cholesterol-lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Rats. Abstract:  INTRODUCTION: Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined.MATERIALS AND METHODS: The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C--D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography.RESULTS AND DISCUSSION: Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C--D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract.CONCLUSIONS: The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels.SUMMARY: The Mangifera indica leaves methanolic extract showed significant cholesterol lowering activity in high cholesterol diet induced hypercholesterolaemia model in rats when evaluated at a dose of 90 mg/kg rat body weight. The extract was found to contain Iriflophenone 3-C--D-glucoside and mangiferin which along with 3 taraxerol and other sterols could be contributing to the cholesterol lowering activity.

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13:02

Mangiferin is potent anti-inflammatory compound that reduces inflammation. GreenMedInfo

PMID:  Sci Rep. 2017 Feb 20 ;7:42683. Epub 2017 Feb 20. PMID: 28218280 Abstract Title:  Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome. Abstract:  Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly understood. In this study we have isolated Mangiferin from the tubers of Pueraria tuberosa (PT-Mangiferin) and analysed the mechanism of its potent anti-inflammatory effects in LPS stimulated RAW 264.7 mouse macrophage cell line and in a carrageenan induced air pouch model. PT-Mangiferin was non-toxic to primary cells but showed significant toxicity and apoptotic effect on cancerous cells. It significantly reduced the production of pro-inflammatory mediators (COX-2, iNOS and TNF-) in LPS stimulated RAW 264.7 cells. Further, it has also reduced the generation of ROS and inhibited LPS induced NF-kB translocation in these cells. Additionally, PT-Mangiferin significantly reduced inflammation in a mouse air pouch model by inhibiting the infiltration of monocytes and neutrophils and reducing the production of cytokines. These effects were mediated via inactivation of NLRP3 inflammasome complex and its downstream signalling molecules. Taken together these results suggest that PT-Mangiferin is potent anti-inflammatory compound that reduces inflammation and holds promise indevelopment of herbal based anti-inflammatory therapeutics in future.

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12:46

The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide. GreenMedInfo

PMID:  J Ayurveda Integr Med. 2017 Apr - Jun;8(2):62-67. Epub 2017 Jun 10. PMID: 28610894 Abstract Title:  Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity. Abstract:  BACKGROUND: Mangiferin is a highly potent antioxidant present in mango leaves which is utilized for therapeutic purposes.OBJECTIVE: The present study was undertaken to evaluate the cardioprotective effect of mangiferin against cyclophosphamide induced cardiotoxicity.MATERIALS AND METHODS: Rats were treated with 100 mg/kg of mangiferin in alone and interactive groups for 10 days. Apart from normal and mangiferin control groups, all the groups were subjected to cyclophosphamide (200 mg/kg, i.p.) toxicity on Day 1 and effects of different treatments were analyzed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile and histopathological evaluation.RESULTS: Mangiferin treated group showed decrease in serum biomarker enzyme levels and increase in tissue antioxidant levels. Compared to cyclophosphamide control group, mangiferin treated animals showed improvement in lipid profile, electrocardiographic parameters, histological score and mortality.CONCLUSION: The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.

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12:18

Mangiferin ameliorated hyperlipidemia by intervening in some major metabolic pathway. GreenMedInfo

PMID:  Food Funct. 2017 Jul 19 ;8(7):2455-2464. PMID: 28617510 Abstract Title:  A (1)H-NMR based metabolomics study of the intervention effect of mangiferin on hyperlipidemia hamsters induced by a high-fat diet. Abstract:  It has been demonstrated that mangiferin can ameliorate hypertriglyceridemia by modulating the expression levels of genes involved in lipid metabolism in animal experiments, but its effects on the serum metabolic fingerprinting of hyperlipidemia animal models have not been reported. Thus, a NMR-based metabolomics approach was conducted to explore the effects of mangiferin on hyperlipidemia hamsters and to gain a better understanding of the involved metabolic pathways. Hamsters fed with a high-fat diet were orally administered with mangiferin 150 mg per kg BW once a day for 8 weeks. Serum samples were analysed by (1)H NMR, and multivariate statistical analysis was applied to the data to identify potential biomarkers. In total, 20 discriminating metabolites were identified. It turned out that mangiferin administration can partly reverse the metabolism disorders induced by a high-fat diet and exerted a good anti-hypertriglyceridemia effect. Mangiferin ameliorated hyperlipidemia by intervening in some major metabolic pathways, involving glycolysis, the TCA cycle, synthesis of ketone bodies, and BCAAs as well as choline and lipid metabolism. These findings provided new essential information on the effects of mangiferin and demonstrated the great potential of this nutrimetabolomics approach.

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12:13

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation. GreenMedInfo

PMID:  Mol Med Rep. 2017 Aug ;16(2):1328-1332. Epub 2017 Jun 12. PMID: 28627701 Abstract Title:  Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation. Abstract:  Mangiferin is a polyphenolic compound present in Salacia reticulata. It has been reported to reduce bone destruction and inhibit osteoclastic differentiation. This study aimed to determine whether mangiferin directly affects osteoblast and osteoclast proliferation and differentiation, and gene expression in MC3T3E1 osteoblastic cells and osteoclastlike cells derived from primary mouse bone marrow macrophage cells. Mangiferin induced significantly greater WST1 activity, indicating increased cell proliferation. Mangiferin induced significantly increased alkaline phosphatase staining, indicating greater cell differentiation. Reverse transcriptionpolymerase chain reaction (RTPCR) demonstrated that mangiferin significantly increased the mRNA level of runtrelated transcription factor 2 (RunX2), but did not affect RunX1 mRNA expression. Mangiferin significantly reduced the formation of tartrateresistant acid phosphatasepositive multinuclear cells. RTPCR demonstrated that mangiferin significantly increased the mRNA level of estrogen receptor  (ER), but did not affect the expression of other osteoclastassociated genes. Mangiferin may inhibit osteoclastic bone resorption by suppressing differentiation of osteoclasts and promoting expression of ER mRNA in mouse bone marrow macrophage cells. It also has potential to promote osteoblastic bone formation by promoting cell proliferation and inducing cell differentiation in preosteoblast MC3T3E1 cells via RunX2. Mangiferin may therefore be useful in improving bone disease outcomes.

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12:04

Mangiferin protects osteoblast against oxidative damage. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2017 Sep 23 ;491(3):807-813. Epub 2017 Jun 30. PMID: 28669729 Abstract Title:  Mangiferin protects osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling. Abstract:  Oxidative stress has currently been proposed as a risk factor associated with the development and proression of osteoporosis. In this study, we identify the effect of mangiferin (MAN) on apoptosis and differentiation of osteoblast-like MC3T3-E1 cells insulted by H2O2. We firstly found that MAN can promote cell proliferation of MC3T3-E1 cells in a time- and dose-dependent manner and stimulate the phosphorylation of ERK5. Cells were divided as five groups: control, H2O2 (100 M, control), H2O2 + MAN (5 M), H2O2 + MAN (10 M), and H2O2 + MAN (20 M). MAN can significantly decrease H2O2-induced apoptosis and elevated ROS level of MC3T3-E1 cells. The expressions of caspase-3, caspase-9 and Bax/Bcl-2 were increased with H2O2 treatment, and MAN can reverse these changes. In addition, Nrf2 and its downstream target effectors (HO1, NQO1) were dramatically attenuated in MC3T3-E cells treatment with H2O2, while MAN can significantly increase the expression of Nrf2, HO1 and NQO1. The expression of ERK5 was down regulated by RNA interference in MC3T3-E1 cells, and we found that MAN (20 M) pretreatment didn't make remarkable decrease in cell apoptosis or expressions of apoptosis-related proteins in H2O2-insulted siRNA-ERK5 cells. This study indicated that MAN can protect osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling, which can be new agent for osteoporosis.

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11:14

Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells. GreenMedInfo

PMID:  Oncol Rep. 2017 Sep ;38(3):1431-1441. Epub 2017 Jul 13. PMID: 28714011 Abstract Title:  Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3. Abstract:  Ovarian cancer is the most lethal gynecological malignancy in the world. Our previous studies showed that mangiferin, purified from plant source, possessed anti-neoplasm effect on human lung adenocarcinoma A549 cells. This study aimed to determine the apoptosis-inducing effect of mangiferin on human ovarian carcinoma OVCAR3 cells. By in vitro studies, we found mangiferin significantly inhibited viability of OVCAR3 cells, and remarkably increased the sensitivity of OVCAR3 cells to cisplatin. In addition, the activation of caspase-dependent apoptosis was observed in mangiferin treated ovarian cancer cells. Importantly, we observedan obviously downregulated Notch expression after mangiferin treatment, indicating the crucial role of Notch in mangiferin mediated apoptosis. In contrast, overexpression of Notch3 abrogated the apoptosis-inducing efficacy of mangiferin, further demonstrating that mangiferin induced apoptosis via Notch pathway. Furthermore, OVCAR3 cell xenograft models revealed that mangiferin treatment inhibited tumor growth and expanded survival of tumor xenograft mice. Based on these results, we concluded that mangiferin could significantly inhibit the proliferation and induce apoptosis in OVCAR3 cells. Ourstudy also suggested the anti-neoplasm effect of mangiferin might be via the regulation of Notch3. Taken together, by targeting cell apoptosis pathways and enhancing the response to cisplatin treatment, mangiferin may represent a potential new drug for the treatment of human ovarian cancer.

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11:09

Mangiferin is neuroprotective against early brain injury after subarachnoid hemorrhage. GreenMedInfo

PMID:  Sci Rep. 2017 Sep 19 ;7(1):11883. Epub 2017 Sep 19. PMID: 28928429 Abstract Title:  Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation. Abstract:  Early brain injury (EBI) is involved in the process of cerebral tissue damage caused by subarachnoid hemorrhage (SAH), and multiple mechanisms, such as apoptosis and inflammation, participate in its development. Mangiferin (MF), a natural C-glucoside xanthone, has been reported to exert beneficial effects against several types of organ injury by influencing various biological progresses. The current study aimed to investigate the potential of MF to protect against EBI following SAH via histological and biological assessments. A rat perforation model of SAH was established, and MF was subsequently administered via intraperitoneal injection at a low and a high dose. High-dose MF significantly lowered the mortality of SAH animals and ameliorated their neurological deficits and brain edema. MF also dose-relatedly attenuated SAH-induced oxidative stress and decreased cortical cell apoptosis by influencing mitochondria-apoptotic proteins. In addition, MF downregulated the activation of the NLRP3 inflammasome and NF-B as well as the production of inflammatory cytokines, and the expression of Nrf2 and HO-1 was upregulated by MF. The abovementioned findings indicate that MF is neuroprotective against EBI after SAH and Nrf2/HO-1 cascade may play a key role in mediating its effect through regulation of the mitochondrial apoptosis pathway and activation of the NLRP3 inflammasome and NF-B.

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10:42

Magic Mushrooms Could Hit a Reset Button on Depressed Brains Natural Blaze

magic mushroom reset

By Heather CallaghanEditor

Psilocybin appears to reset brain activity of depressed patients stunning results

To be sure, of all the recent human trials to come out showing the promises of psilocybin the hallucinogenic compound found in magic mushrooms its only the scientists who are surprised by the stunning brain changes from psychedelics. (Then again, behold the results for yourself.)

Thats what happened when Robin Carhart-Harris of Imperial College London and his colleagues announced the good news today with their newly published study in Scientific Reports. They ran 19 depressed and treatment-resistant volunteers through a magic mushroom trial to look at the results in their brains. Previously, Carhart-Harris and his team ran 12 people through a similar trial and five months later, 5 of them were still free of depression. That report detailed the spiritual benefits of psilocybin for depression.

...

10:02

RIP Maryanne Godboldo, Champion of Children's Medical Rights AGE OF AUTISM

NOTE: We are sad to report that Maryanne has passed away. She was a Michigan Mom dedicated to her daughter's well being - and willing to fight even a SWAT team to defend her daughter's medical rights. She was exonerated...

08:38

Are Government Nutrition Recommendations Killing Us? Health Impact News

farmers-market-web-702x336

by ANH-USA

A brand new study suggests the answer may be yes.

The study, published in The Lancet, is the first major study to look at all-cause mortality and cardiovascular disease and nutrition. Here are just two of the major takeaways

  • High carb diets are killing many of us around the world. The study tracked over 135,000 people aged between 35 and 70 from 18 countries; those on a low fat/high carb diet had an increased risk of early death compared to those on a lower carb/higher fat diet.
  • Raw and cooked vegetables are not created equal. Broadly speaking, the study showed that consumption of raw vegetables was more protective against cardiovascular disease than cooked vegetables. As our colleagues at ANH-International point out, many phytochemicals, vitamins, and other nutrients are heat-sensitive and may be damaged by heat.

These findings, particularly on fat versus carbs, echo our criticisms of the governments Dietary Guidelines for Americans that were released in 2016. Those guidelines encourage Americans to reduce consumption of saturated fat, based on the outdated notion that fat leads to heart disease.

Dont wait until 2020 when the US government next updates its Dietary Guidelines. History tells us the revised guidelines wont change much. Pressure from Big Food, Big Ag, Big Biotech and their revolving doors with the USDA, NIH and FDA will likely still override the state-of-the-art of nutritional science. 

The bottom line is that government should not be in charge of doling out nutrition advice. As the latest research suggests, government advice is likely killing us.

Were going to continue doing everything we can with our medical and scientific partners and collaborators to influence decision-making and expose the cor...

07:41

4 TED-Ed Lessons about mental health everyone needs to watch Healthy Holistic Living

We are all prone to having bad days. If you are human, its inevitable that a bad test score, a fight with a loved one, or even a rainy day can turn your whole mood upside down. For most of us, a positive outlook and maybe a few pieces of...

More

The post 4 TED-Ed Lessons about mental health everyone needs to watch appeared first on Healthy Holistic Living.

07:09

21 Simple Exercises You Can Do to Make Your Knees Strong Healthy Holistic Living

This article is shared with permission from our friends at Paleohacks. Knee pain is common problem that plagues people of all ages. In the US, its the cause for about 1/3 of all doctors visits for muscle and bone pain. It can affect our daily life, ability to participate in activities, and even...

More

The post 21 Simple Exercises You Can Do to Make Your Knees Strong appeared first on Healthy Holistic Living.

05:47

Dr. Brownstein: Another Study Showing Influenza Vaccine Failure Flu Vaccine Fails 98% of People Who Receive It Health Impact News

Walgreens Flu Shot Ad

Advertisement for flu vaccines at Walgreens pharmacy website. Image source.

Time For A Flu Vaccine? Fugetaboutit!

by Dr. Brownsteins
Holistic Medicine

The flu and cold season is upon us.  I have already seen numerous patients suffering with upper respiratory illnesses and even weathered my first bout.

The CDC and the Powers-That-Be would have you believe that you should receive the influenza vaccine on a yearly basis. (1) They claim that the flu vaccine can save thousands of lives.  Of course, I have written to you many times that there is not a single study that has ever supported the claim that the flu vaccine saves any lives.  In fact, the history of the flu vaccine shows clearly that it fails nearly all who take it.

A recent article in Family Practice News (September 1, 2017, p. 10) was titled, Inactivated quadrivalent influenza vaccine safe, effective.  The article states, An intramuscular inactivated quadrivalent influenza vaccine reduced the risk of laboratory-confirmed influenza by up to 69% in previously unvaccinated children aged 6-35 months in a large randomized trial, reported at the annual meeting of the European Society for Paediartic (sic) Infectious Diseases.

Wow. I have studied the influenza vaccine for years and I know that there is not one study that has shown the flu vaccine very effective for preventing the flu.  Is this something new?

I pulled the study and read it. Heres what I found.

The study included 5,806 healthy 6-35-months-olds.  More than 5,400 were randomized to two doses of the quadrivalent vaccine (Fluzone) or placebo .  The trial was conducted in Europe, Asia, South America and Africa between March 2014 and September 2016.  The incidence of any laboratory-confirmed strain of influenza illness during the period from 14 days post-vaccination to the end of the flu season was 1.01% in the Fluzone group and 3.28% in those who received the placebo.

How did they get the 69% efficacy rate?  They used the relative risk statistica...

05:39

Rebecca Bredows Husband Exposed For Leaving Vaccinated Son Behind Vaxxter

The mother who was thrown into jail for not vaccinating her child lost primary custody of her son. Her husband, who Rebecca Bredow claims was agreeable to at least hold off on vaccinations, changed his...

The post Rebecca Bredows Husband Exposed For Leaving Vaccinated Son Behind appeared first on Vaxxter.

05:07

Most of Us Are Ingesting Plastic Fibers Without Even Realizing It Natural Blaze

By Anna Hunt

Plastic, once regarded as convenient and versatile, has actually become one of the biggest environmental problems of our time. Its easy to see the extend of the contamination when you visit the oceanside. Even the most remote beaches are often littered with plastic debris. Now, new evidence reveals the problem of plastic pollution hits much closer to home. Microplastics, invisible to the human eye, are present in our drinking water, and as a result are polluting our bodies.

   SEE: Invisible Plastic Nanoparticles Now Being Found In Drinking Water

Study Reveals We are Ingesting Plastic Fibers via Tap Water

An investigation commissioned by Orb Media revealed that microplastics were present in 83 percent of drinking water samples. The study encompassed more than a dozen countries, including the U.S., the U.K., France, Germany, Lebanon, Indonesia, Equator, and India.

When comparing contamination rates, the U.S. had the highest rate at 94 percent. This means that researchers found plastic fibers in 94 percent of the water samples collected at dozens of locations around the country.

Startlingly, each country in the analysis had a contamination rate of more than 70 percent.

Dr. Sherri Mason is a microplastic expert at the State University of New York in Fredonia. Sh...

05:05

Dr. Brownstein: Another Study Showing Influenza Vaccine Failure Flu Vaccine Fails 98% of People Who Receive It Vaccine Impact

Walgreens Flu Shot Ad

Advertisement for flu vaccines at Walgreens pharmacy website. Image source.

Time For A Flu Vaccine? Fugetaboutit!

by Dr. Brownsteins
Holistic Medicine

The flu and cold season is upon us.  I have already seen numerous patients suffering with upper respiratory illnesses and even weathered my first bout.

The CDC and the Powers-That-Be would have you believe that you should receive the influenza vaccine on a yearly basis. (1) They claim that the flu vaccine can save thousands of lives.  Of course, I have written to you many times that there is not a single study that has ever supported the claim that the flu vaccine saves any lives.  In fact, the history of the flu vaccine shows clearly that it fails nearly all who take it.

A recent article in Family Practice News (September 1, 2017, p. 10) was titled, Inactivated quadrivalent influenza vaccine safe, effective.  The article states, An intramuscular inactivated quadrivalent influenza vaccine reduced the risk of laboratory-confirmed influenza by up to 69% in previously unvaccinated children aged 6-35 months in a large randomized trial, reported at the annual meeting of the European Society for Paediartic (sic) Infectious Diseases.

Wow. I have studied the influenza vaccine for years and I know that there is not one study that has shown the flu vaccine very effective for preventing the flu.  Is this something new?

I pulled the study and read it. Heres what I found.

The study included 5,806 healthy 6-35-months-olds.  More than 5,400 were randomized to two doses of the quadrivalent vaccine (Fluzone) or placebo .  The trial was conducted in Europe, Asia, South America and Africa between March 2014 and September 2016.  The incidence of any laboratory-confirmed strain of influenza illness during the period from 14 days post-vaccination to the end of the flu season was 1.01% in the Fluzone group and 3.28% in those who received the placebo.

How did they get the 69% efficacy rate?  They used the relative risk statistical a...

04:46

FIRED: Utah Officer Caught on Video Brutally Arresting Nurse for Doing Her Job, Loses His REALfarmacy.com

Source: FIRED: Utah Officer Caught on Video Brutally Arresting Nurse for Doing Her Job, Loses His For more content like this visit REALfarmacy.com.

A Utah police officer who captured on video [below] brutally arresting and dragging on-duty nurse, Alex Wubbels, from the emergency room, after she refused to allow an unconscious patients blood to be drawn without a warrant has now been fired from his job in law enforcement. Now-former Detective Jeff Payne had previously been []

Source: FIRED: Utah Officer Caught on Video Brutally Arresting Nurse for Doing Her Job, Loses His Learn more at REALfarmacy.com - Healthy News and Information.

04:25

The Zika-Microcephaly Hoax A Replay Of The Dangerous DDT-Polio Sham? Natural Blaze

ddt polio

By 

DDT-POLIO

1946-1955: Mass DDT spraying campaigns across the US to purportedly kill mosquitoes (fraudulently) blamed for carrying the polio virus and causing poliomyelitis paralysis. Mass DDT spraying campaign ended up CAUSING the poliomyelitis paralysis epidemic in the US in the 1950s.

In response, Big Pharma developed and administered over 100 million doses of the polio vaccine to children and pregnant women in the US, which CAUSED millions of cases of poliomyelitis paralysis in the US!

In 1992, the CDC publicly admitted that every case of poliomyelitis paralysis in the US since the early 1960s was CAUSED by the oral polio vaccine (OPV) used in the US from the early 1960s to 2000! Moreover, as far back as 1976, Dr Salk publicly admitted under testimony that the OPV used in the US from the early 1960s to 2000 was the principal if not the sole cause of all poliomyelitis paralysis cases in the US since 1961.

Read this paper for details about the murderous DDT-POLI...

03:42

Death Toll Rises to 31, 400+ Missing: Wildfires Become Deadliest in States History REALfarmacy.com

Source: Death Toll Rises to 31, 400+ Missing: Wildfires Become Deadliest in States History For more content like this visit REALfarmacy.com.

Over 8,000 firefighters battling at least 21 major wildfires face another devastating round of low humidity, arid foliage, and powerful wind gusts up to 60 mph this weekend. Californias blazing 191,437 acres of wildfire that has broken out during recent days is now be called the deadliest in state history. The death toll from the fires has increased to 31 with a report from the Sonoma []

Source: Death Toll Rises to 31, 400+ Missing: Wildfires Become Deadliest in States History Learn more at REALfarmacy.com - Healthy News and Information.

02:19

All Childhood Vaccines Crammed In a Single Shot? Natural Blaze

single shot vaccine

BY 

With more parents speaking out against the new number of recommended childhood vaccinations given at one time, its only psychopathic that the response would be to jam all the vaccinations in to one shot, right? That should totally bypass all parental concerns, right? Editor


We find this really scary.

From BBC News:

A technology that could eventually see every childhood vaccine delivered in a single injection has been developed by US researchers.

Their one-shot solution stores the vaccine in microscopic capsules that release the initial dose and then boosters at specific times.

The approach has been shown to work in mouse studies, described in the journal Science.

Comment: If this appears,  expect approval from the medical establishment, despite the lack of research even on todays vaccine schedule.

As weve noted before, eve...

01:31

Rebecca Bredow Finally Speaks Out In Rare Interview Vaxxter

7 Action News reporter Andrea Isom interviews Rebecca Bredow, the mother who was jailed after not vaccinating her child following a court order.  

The post Rebecca Bredow Finally Speaks Out In Rare Interview appeared first on Vaxxter.

01:11

Are rich people meaner? While trying to find out, two teams find errors in each others work Retraction Watch

Is having money linked to bad behavior? A high profile paper published in 2012 in the Proceedings of the National Academy of Sciences (PNAS) set out to answer that question and found that yes, the more money people have, the more likely they are to lie, cheat, and steal. And the greedier they are, []

The post Are rich people meaner? While trying to find out, two teams find errors in each others work appeared first on Retraction Watch.

00:22

Foster Kids Keep Mysteriously Disappearing In Kansas Vaxxter

If you think state foster systems are poorly run, this new report in the Kansas City Star isnt likely to change your perspective. Kansas has a foster system of 7,000 kids, but a new report...

The post Foster Kids Keep Mysteriously Disappearing In Kansas appeared first on Vaxxter.

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Friday, 13 October

23:24

Youll Be Glad You Watched This Before Vaccinating Your Child! Vaxxter

The number of vaccines in kids recommended vaccine schedules continues to grow. Is this a good thing? Dr. Peter Glidden discusses this topic and addresses one of the main concerns between the research and MDs.

The post Youll Be Glad You Watched This Before Vaccinating Your Child! appeared first on Vaxxter.

23:15

An accomplished philosopher invented a pseudonym. Why? Retraction Watch

In 1980, Leila Tov-Ruach published a book chapter in which she thanked the editor of the book, Amlie Oksenberg Rorty, for the hospitality that made the writing of this paper possible. Normally, such an acknowledgement wouldnt raise eyebrows. But, the trouble is, Tov-Ruach and Rorty are the same person:  Leila Tov-Ruach is a pseudonym for []

The post An accomplished philosopher invented a pseudonym. Why? appeared first on Retraction Watch.

22:50

Rethinking the Validity of Schizophrenia on World Mental Health Day Mad In America

An open letter launched on World Mental Health Day, supported by people with lived experience, friends, family members, workers and researchers, calls on Rethink Mental Illness, one of the major English mental health charities, to co-create a new conversation about the diagnosis schizophrenia.

Rethink has considerable influence in shaping public awareness in England, particularly as it is the lead organisation of a prominent national anti-stigma campaign called Time To Change. For this reason we wanted to find a way to engage them in discussing the validity of the term schizophrenia.

The origins of the open letter arose from our concerns about a recently released Rethink press release and subsequent BBC Online News article Have you got the wrong impression about schizophrenia? published on the 18th of September 2017. In the article the findings of a public attitudes survey about schizophrenia commissioned by Rethink were published. The survey of 1500 people revealed that the condition is widely misunderstood. The article warned that myths about schizophrenia are dangerous. The main findings were:

50% of people think that schizophrenia means you have a split personality
26% believe that schizophrenia makes you violent
23% incorrectly think that someone with schizophrenia needs to be monitored by
professionals at all times
45% of the general public thought the illness much less common than the one in 100
people that have schizophrenia

The article and press release gave a stark warning that myths about schizophrenia are dangerous.

Two quotes from the BBC article illustrate our concerns:

Prof. Wendy Burn, president of the Royal College of Psychiatrists, said it was astounding that schizophrenia was still so widely misunderstood. To tackle the stigma that so many living with schizophrenia face, we have a huge task ahead of us in informing and educating the public.
and

Brian Dow, director of external affairs at Rethink Mental Illness reiterated: Its about time we all got to grips with what schizophrenia is and what it isnt. Schizophrenia can be treated and managed, just like many other illnesses. Its not a dirty word or, worse, a term of abuse. 

We wanted to respond to the position of both commentators because it is based on the mental illness is an illness like any other metaphor. Schizophrenia is not an illness that causes symptoms, it is a term used to categorise peoples experiences. Whilst it may be well-intended in attempting to bestow dignity to the sickness role and to remove blame by educating the public that these people are not responsible for their actions, we wanted to present the counter argument. In our view it has the opposite effect as it reinforces the belief that schizophrenia...

21:03

Film Highlights Harm From Benzo Overuse Mad In America

From The Right Care Alliance: Documentary filmmaker and benzodiazepine survivor Holly Hardman is currently working on a film called As Prescribed, which will document the stories of people dealing with the adverse effects and withdrawal effects of benzodiazepines.

Holly Hardman, documentary filmmaker and Massachusetts resident, was one of these patients. Her doctor prescribed her Klonopin for chronic fatigue syndrome and assured her that the drug was perfectly safe to take long-term. But as her tolerance grew, she experienced strange side effects including gastrointestinal issues, panic attacks while driving, and a foggy, drugged feeling. However, her doctor never connected her symptoms to the drug, which is a common oversight. It was only when Hardman started researching online that she linked her side effects to Klonopin, and created a tapering plan.

It took Hardman almost two years to taper off the drug completely, during which time she experienced even more disturbing side effects such as akathasia, the feeling that you are about to jump out of your skin, and aphasia, the inability to form words and sentences. Even though the withdrawal process was hellish, Hardman knows others who had much worse experiences, and many who did not survive coming off of benzos.

It was after this experience, and hearing the experiences of others, that Hardman knew she had to do something. So she took action in the best way she knew how by making a documentary film.

Article

21:02

Its Easy to Get Caught Up in Constructing Our Selves Mad In America

In this video for Aeon, clinical psychologist Daniel Brown discusses the ways that the construction of a fixed selfhood can limit the possibilities of our awareness and understanding of reality.

21:01

Its All in the Approach: Compassionately Shifting Language Mad In America

In this piece for HuffPost, Brooke M. Feldman discusses the importance of shifting language around mental health and addiction in a compassionate way that does not make people feel shamed or attacked for using stigmatizing terms.

With recognizing what is at play in the task of moving people away from what the language they have been taught to use and the only language they have known, it is imperative that we approach this dialogue from a place of understanding, compassion, patience, respect, empathy and bridge-building rather than attacking, shaming or wronging people. Although those of us who understand the importance of shifting language around mental health and substance misuse must do our due diligence to bring people along whenever and wherever possible, it is critical that we do this in a way that unites rather than divides, that brings people along rather than pushes them further away. It is crucial that we deliver this message in a digestible form for those we are seeking to enlighten and transform. Anything other than that will only further polarize the divide and lead to people hunkering even more deeply down into what they know.

21:00

Michigan Mother Jailed for Not Vaccinating. Exclusive Video of Father Post Court. AGE OF AUTISM

Ah, serendipity! From Del Bigtree: "Rebecca Bredow goes to jail. Dad wins split custody, immediately abandons son to go on The Doctors TV show in Los Angeles. Del Bigtree just happened to be on the same flight. Check it out....

20:59

First Hockey, Now Lacrosse as Mumps "Sticks" Around AGE OF AUTISM

The NHL had an outbreak of the Mumps a few years ago that continues today. Now it seems mumps has sought another stick handling sport - lacrosse. Students at Syracuse are dealing with "isolation" (this used to be called quarantine)...

20:04

Fluoridation in Somers Drinking Water Shut Off Fluoride Action Network

SOMERS, N.Y.A four-year-old mechanical issue has shut down Somers supply of fluoridated drinking water.

Equipment problems halted water fluoridation last week and were expected to keep the cavity-fighting chemical out of the water supply until early 2019, the Northern Westchester Joint Water Works said in a statement.

In the meantime, residents generallyand especially the parents of young childrenare being urged to consider fluoride supplements or other steps to offset loss of the chemical protection.

Dr. Carl H. Tegtmeier of Mount Kisco, an outspoken advocate of fluoridation, said babies and children benefit dramatically from early application. As the teeth form in their jaws, the fluoride is incorporated into the enamel and it makes it much less susceptible to cavities, he said.

If theyre not getting fluoride for a couple of years, it will show up in their getting more cavities, said Tegtmeier, who is chairman of the five-county 9th District Dental Associations Dental Health Committee.

The Northern Westchester Joint Water Works, established in 1995, serves Somers, Yorktown, Cortlandt and the Montrose Improvement District. Among other things, it treats drinking water with fluoride, optimally at a ratio of 0.7 parts per million gallons of tap water.

The fluoridation plant serving all of Somers and about a third of Yorktownthe Amawalk Water Treatment Facilitydoes not have a mechanical problem. But a second Water Works plantthe Catskill Water Treatment Facility in Cortlandt, which provides the other two-thirds of Yorktowns tap waterhas been having problems for almost four years.

The fluoride feed system at our Catskill Facility has been off line since January 2013, the Water Works said last week in a prepared statement, and under engineering review for an upgrade. Matthew Geho, the Works operations director, was not immediately available to expand on the statement.

But Tegtmeier said Yorktowns fluoridated Amawalk output mixed with the untreated Catskill supply, making it impossible to estimate fluoride levels in the water or calculate the strength of alternative solutions that dentists could prescribe.

We had no idea, day to day, who was getting what level, and so there were suboptimal levels of fluoridation going on, Tegtmeier said. Somers was probably getting the optimal level, but as it came across Yorktown going to the west, people were not getting it.

By removing all fluoride, he said, dentists will have a uniform standard against which to prescribe preventive measures.

Westchester health officials decidedand dentists agreedthat it was better to eliminate fluoride completely on a temporary basis so proper supplements could be prescribed.

Theres no other way to do it, Tegtmeier said. Some days youre getting the right amount [of fluoride in the tap water]; other days, youre not.

Tegtmeier in...

16:31

A Traumatic History: A Unique Look at PTSD and the Dangers of Antidepressants Mad In America

A Traumatic History: A Unique Look at PTSD and the Dangers of Antidepressants is a memoir by Barclay Neel about his experience with and recovery from PTSD, a condition that was in large part set in motion by an extreme adverse reaction to an antidepressant. The book describes how the author was prescribed an SSRI after a 15-minute consultation with little warning of side effects, and how quickly things went south.

The book also chronicles the authors withdrawal process from the SSRI in great detail. He was told by a doctor that he could quit cold turkey but instead opted to wean off over a five-day period. The full scope of his withdrawal process, including conversations with doctors and psychiatrists, is recounted.

The book is currently being shared in a handful of social work and psychology graduate programs across the country. It is available on Amazon for $8.99 on Kindle and $14.99 in paperback.

16:00

Growing Guide for Melons Articles

By Dr. Mercola

Sweet, succulent and delicious, melons are one of the largest fruits, offering a completely unique flavor among all other fruit offerings. Why grow them yourself?

One reason is because commercially grown melons are picked at a slightly unripe state to survive being shipped long distances, and there's also a good chance they'll sit in a truck, on a skid in the back of the grocery store or in a bin among dozens of others, so they're picked when they're still a little green if growers and food chains want them presented for sale at peak ripeness.

However, the longer melons remain on the vine, the sweeter and more delicious they become. That explains why you've probably purchased what looks to be a perfectly ripe melon at the grocery store but found it rather bland once it was cut. The solution is growing your own. Can you imagine having vines that grow at the rate of a few inches a day and watching golf ball-sized melons forming that will turn into large, juicy, scrumptious food?

Melons contain fiber, vitamin B6 and folate, plus excellent amounts of vitamin C to fight infection and vitamin A for improved vision. In addition, flavonoids include beta-carotene, lutein and zeaxanthin, which is a carotenoid absorbed into the retina that may provide light-filtering functions to protect against age-related macular degeneration.

Potassium in melons helps control heart rate and blood pressure and protects against stroke and heart disease. Manganese, also found in melons, is a cofactor for the enzyme superoxide dismutase, a powerful antioxidant.

Origins and Varieties of Muskmelons (aka Cantaloupes)

There are many types of melons; Horticulture at Oregon State University notes that although all melons are classified as Cucumis melo, what's grown in the U.S. are the netted, aromatic and Persian (reticulatus) varieties. True cantaloupes are grown mostly in Europe (cantaloupensis), although most people in the U.S. call muskmelons cantaloupes.

Other cultivars are casabas, crenshaws, honeydews and late-maturing winter melons (inodorous), which are more oval with a waxy surface, smooth or wrinkled and less fragrant. These begin ripening as the weather starts to cool and require a full 100 days on the vine. There's also the snake melon (flexuosus), grown in Asia, and the Oriental pickling melon (conomon).1

M...

How to Grow Ginger at Home Articles

By Dr. Mercola

Ginger is a spice well worth having on hand at all times. Not only is it a wonderful addition to your cooking (and can be used in a number of beverages) but it also has a wide variety of medicinal benefits, including broad-spectrum antibacterial, antiviral, antioxidant and antiparasitic properties.

It's a rich source of antioxidants including gingerols, shogaols and paradols, all of which have documented anticancer activity.1 Furthermore, because ginger helps prevent the toxic effects of many substances (including cancer drugs), it may be useful to take in addition to conventional cancer treatments.2

Sampling of Ginger's Health Benefits

Ginger has also been shown to:

Enhance the bronchodilation in asthmatics

Improve blood glucose, triglyceride, total cholesterol and LDL cholesterol levels in diabetics. It also benefits diabetics by inhibiting carbohydrate metabolism and improving insulin sensitivity3

Relieve motion sickness, morning sickness in pregnant women4 and general nausea and upset stomach

Made into hot tea, ginger releases the compounds gingerol and protease, bringing a rush of comforting warmth that actually increases cardiovascular circulation. Its potent anti-inflammatory effects make it a particularly valuable tool for all sorts of pain relief. For example, research has shown it can help:

Reduce knee pain associated with osteoarthritis5

Decrease muscle soreness in athletes6

Relieve...

14:54

Combined use of doxycycline and vitamin C could represents a new synthetic-lethal metabolic strategy for eradicating CSCs. GreenMedInfo

PMID:  Oncotarget. 2017 Sep 15 ;8(40):67269-67286. Epub 2017 Jun 9. PMID: 28978032 Abstract Title:  Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs). Abstract:  Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The expression of four mitochondrial DNA encoded proteins (MT-ND3, MT-CO2, MT-ATP6 and MT-ATP8) is suppressed, by up to 35-fold. This high selection pressure metabolically synchronizes the surviving cancer cell sub-population towards a predominantly glycolytic phenotype, resulting in metabolic inflexibility. We directly validated this Doxycycline-induced glycolytic phenotype, by using metabolic flux analysis and label-free unbiased proteomics. Next, we identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for metabolically targeting the Doxycycline-resistant CSC population (Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol). This new combination strategy allows for the more efficacious eradication of CSCs with Doxycycline, and provides a simple pragmatic solution to the possible development of Doxycycline-resistance in cancer cells. In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs. This type of metabolic Achilles' heel will allow us and others to more effectively"starve"the CSC population.

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14:35

Resveratrol and pterostilbene appear potentially very useful to control and inhibit biofilm contaminations. GreenMedInfo

PMID:  Folia Microbiol (Praha). 2017 Oct 2. Epub 2017 Oct 2. PMID: 28971316 Abstract Title:  Resveratrol, pterostilbene, and baicalein: plant-derived anti-biofilm agents. Abstract:  Microbial adhesion to surfaces and the subsequent biofilm formation may result in contamination in food industry and in healthcare-associated infections and may significantly affect postoperative care. Some plants produce substances with antioxidant and antimicrobial properties that are able to inhibit the growth of food-borne pathogens. The aim of our study was to evaluate antimicrobial and anti-biofilm effect of baicalein, resveratrol, and pterostilbene on Candida albicans, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli. We determined the minimum inhibitory concentrations (MIC), the minimum adhesion inhibitory concentration (MAIC), and the minimum biofilm eradication concentration (MBEC) by crystal violet and XTT determination. Resveratrol and pterostilbene have been shown to inhibit the formation of biofilms as well as to disrupt preformed biofilms. Our results suggest that resveratrol and pterostilbene appear potentially very useful to control and inhibit biofilm contaminations by Candida albicans, Staphylococcus epidermidis, and Escherichia coli in the food industry.

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14:17

This gives insight into the potential application of pterostilbene and megestrol acetate combination for the treatment of endometrial cancer. GreenMedInfo

PMID:  Sci Rep. 2017 Oct 6 ;7(1):12754. Epub 2017 Oct 6. PMID: 28986550 Abstract Title:  Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer. Abstract:  Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which are frequently toxic, are difficult to establish in this patient population which tends to be older and plagued by comorbidities such as diabetes mellitus and hypertension. Therefore, novel, non-toxic therapies are urgently needed. Megestrol acetate is a frequently used drug in endometrial cancer patients. However, its response rate is only 20-30%. To enhance the activity of megestrol acetate in endometrial cancer patients, we explored the potential of combining natural supplements with megestrol acetate and found that the addition of the natural phenolic compound, pterostilbene, to megestrol acetate resulted in a synergistic inhibition of cancer cell growth in vitro and an enhanced reduction of tumor growth in a xenograft mouse model. In addition, dual treatment led to attenuation of signaling pathways, as well as cell cycle and survival pathways. Our results demonstrated for the first time that the anti-tumor activity of megestrol acetate can be enhanced by combining with pterostilbene, providing an insight into the potential application of pterostilbene and megestrol acetate combination for the treatment of endometrial cancer.

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12:14

Whooping Cough Outbreaks Traced Back to Vaccine Failure Health Impact News

pertussis-vaccine-failure

Whooping Cough Reemergence Traced Back to Vaccine Failure and Flawed Assumptions

by Dr. Mercola

The pertussis (whooping cough) vaccine is included as a component in combination shots that include tetanus and diphtheria (DPT, DTaP, Tdap) and some pertussis-containing shots now also include polio, hepatitis B and/or Haemophilus Influenza B (Hib). Whole cell pertussis vaccines in DPT, used in the U.S. from 1949 until the late 90s, were estimated to be between 30 and 85 percent effective, depending upon the type of DPT and vaccine manufacturer, with protection lasting only two to five years. [1]

The DPT vaccine was highly reactive and carried a high risk of serious allergic reactions and brain inflammation leading to permanent brain damage, as detailed in the groundbreaking 1985 book DPT: A Shot in the Dark, co-authored by Barbara Loe Fisher, cofounder of the National Vaccine Information Center.

DTaP shots which contain the less reactive acellular pertussis vaccine licensed for infants in the United States in 1996 are given five times to children under age 6, with additional Tdap booster doses recommended for teenagers and adults. Since the late 1980s, CDC data shows that kindergarten children in the U.S. have maintained a high vaccination rate with four to five DPT shots and, today, more than 94 percent of kindergarten children have had four to five acellular DTaP vaccines.

Very high pertussis vaccination rates in the U.S. and many other countries for the past several decades should be more than sufficient to achieve vaccine-acquired herd immunity, if the theory of vaccine-acquired herd immunity is correct. [2] Yet, despite high vaccine coverage, statistics show reported whooping cough cases continue to rise. So, whats really going on?

Studies Show Pertussis Vaccine Doesnt Work

Scientific findings suggest whooping cough vaccines both whole cell and acellular fail to provide adequate protection against infection and the transmission of infection. There are indications that subclinical and undiagnosed pertussis infections have been occurring since the early 1980s among both vaccinated and unvaccinated persons.

Now, a recently published scientific study [3,4] confirms the acellular whooping cough vaccine does not work as expected ...

12:02

FREE Replay of Event on Preventing, Treating and Beating Cancer Health Impact News

Replay-Cancer Event

Health Impact News

The Truth About Cancer LIVE 2017 is in the history books. Over three amazing days, we heard 40 leading cancer and health experts share their research and knowledge on how to heal and prevent cancer naturally.

What people heard and saw over last weekend changed their lives dramatically and filled us with hope for a cancer-free future.

We hope you had a chance over the weekend to tune in to some or all of the LIVESTREAM event.

If you did it was impossible to see each and every speaker. With nine breakout sessions and three stages along with a dozen keynote speakers youre sure to have missed something.

But weve got great news

You have a second chance to see the event.

Ty and his team recorded the entire event. And this weekend, you can tune in once again as The Truth About Cancer LIVE 2017 the entire weekend is replayed.

Starting on Friday, October 13th at 8:30am Eastern, Ty will replay the whole event online for you to watch for FREE.

So please take a minute and reserve your spot now.

You can watch any of the incredible presentations you missed or re-watch your favorites. Its all there for you during this special replay weekend.

Heres just a of the presenters:

  • Dr. Patrick Quillin Beating Cancer with Nutrition
  • Dr. Joseph Mercola Ketogenic Diet and Cancer
  • Dr. Robert Scott Bell Gut Health, the Microbiome, and Cancer
  • Dr. Rashid Buttar -The Cancer Conflict: Resolving the 5th Toxicity
  • Dr. Tony Jimenez Treating Cancer with Sound and Light
  • Mike Adams The importance of ORGANIC
  • Del Bigtree Freedom of Choice in Medicine
  • Chris Wark How Chris Beat Cancer
  • Plus SO many more

Go here to register while theres still time.

...

11:37

Ethanol extracts of the rhizome of Atractylodes macrocephala may be useful in preventing and treating various bone diseases. GreenMedInfo

PMID:  Molecules. 2013 Jun 24 ;18(7):7376-88. Epub 2013 Jun 24. PMID: 23884114 Abstract Title:  Ethanol extract of Atractylodes macrocephala protects bone loss by inhibiting osteoclast differentiation. Abstract:  The rhizome of Atractylodes macrocephala has been used mainly in Traditional Chinese Medicine for invigorating the functions of the stomach and spleen. In the present study, we investigated the inhibitory effect of the 70% ethanol extract of the rhizome of Atractylodes macrocephala (AMEE) on osteoclast differentiation. We found that AMEE inhibits osteoclast differentiation from its precursors induced by receptor activator of nuclear factor-B ligand (RANKL), an essential cytokine required for osteoclast differentiation. AMEE attenuated RANKL-induced activation of NF-B signaling pathway, subsequently inhibiting the induction of osteoclastogenic transcription factors, c-Fos and nuclear factor of activated T cells cytoplasmic 1. Consistent with the in vitro results, administration of AMEE protected RANKL-induced bone loss in mice. We also identified atractylenolide I and II as active constituents contributing to the anti-osteoclastogenic effect of AMEE. Taken together, our results demonstrate that AMEE has a protective effect onbone loss via inhibiting osteoclast differentiation and suggest that AMEE may be useful in preventing and treating various bone diseases associated with excessive bone resorption.

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11:21

A review of the preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases. GreenMedInfo

PMID:  CNS Neurosci Ther. 2017 Oct 4. Epub 2017 Oct 4. PMID: 28980404 Abstract Title:  Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases. Abstract:  In this review, we summarize the involvement of ascorbic acid in neurodegenerative diseases by presenting available evidence on the behavioral and biochemical effects of this compound in animal models of neurodegeneration as well as the use of ascorbic acid as a therapeutic approach to alleviate neurodegenerative progression in clinical studies. Ascorbate, a reduced form of vitamin C, has gained interest for its multiple functions and mechanisms of action, contributing to the homeostasis of normal tissues and organs as well as to tissue regeneration. In the brain, ascorbate exerts neuromodulatory functions and scavenges reactive oxygen species generated during synaptic activity and neuronal metabolism. These are important properties as redox imbalance and abnormal protein aggregation constitute central mechanisms implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, multiple sclerosis, and amyotrophic lateral sclerosis. Indeed, several studies have indicated an association between low serum ascorbate concentrations and neurodegeneration. Moreover, ascorbic acid is a suitable candidate for supplying either antioxidant defense or modulation of neuronal and astrocytic metabolism under neurodegenerative conditions. Ascorbic acid acts mainly by decreasing oxidative stress and reducing the formation of protein aggregates, which may contribute to the reduction of cognitive and/or motor impairments observed in neurodegenerative processes. Although several studies support a possible role of ascorbic acid administration against neurodegeneration, more researches are essential to substantiate the existing results and accelerate the knowledge in this field.

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11:11

Blueberry juice shows similar anti-oxidative or anti-premutagenic activity to vitamin C. GreenMedInfo

PMID:  J Cancer Prev. 2017 Sep ;22(3):174-181. Epub 2017 Sep 30. PMID: 29018782 Abstract Title:  Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human. Abstract:  BACKGROUND: Chemopreventive effects and the underlying mechanisms of blueberry (Vaccinium spp.) are not clearly understood in human. We hypothesized blueberry would work via antioxidative and epigenetic modulation, which is similar to vitamin C.METHODS: We performed a pilot and non-inferiority study in healthy young women (n = 12), who consumed vitamin C (1 g/d) or 240 mL of blueberry juice (total polyphenols 300 mg and proanthocyanidin 76 mg/d) for 2 weeks. We analyzed 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in their urine, and global and specific DNA methylation at the NAD(P)H quinone oxidoreductase 1 (NQO1), methylenetetrahydrofolate reductase (MTHFR), or DNA methyltransferase 1 (DNMT1) genes in their blood.RESULTS: Urinary 8-OHdG levels were reduced by blueberry consumption rather than by vitamin C. The methylation (%) of the MTHFR was significantly decreased in blueberry-consumers and the antioxidant-susceptible subgroup, whose urinary MDA levels were decreased by the intervention. We also found a positive correlation between changes of urinary 8-OHdG and of DNA methylation at the MTHFR or the DNMT1 (P

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10:15

Exposure to animal foods may favor an intestinal environment which could trigger systemic inflammation and metabolic disorders. GreenMedInfo

PMID:  Diabetol Metab Syndr. 2017 ;9:62. Epub 2017 Aug 15. PMID: 28814977 Abstract Title:  Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition. Abstract:  AIMS: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile.METHODS: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene. Samples were clustered into operational taxonomic units at 97% similarity using GreenGenes 13.5 database. Clinical, biochemical, and circulating inflammatory markers were compared by ANOVA or Kruskal-Wallis test.RESULTS: The sample (54.2% women, mean age 49.5 years) was composed of 66 strict vegetarians, 102 lacto-ovo-vegetarians and 100 omnivores. Considering the entire sample, the greatest abundant phyla were Firmicutes (40.7  15.9%) and Bacteroidetes (39.5  19.9%), and no difference in abundances was found between individuals with normal andexcess weight. Stratifying by dietary types, the proportion of Firmicutes was lower and of Bacteroidetes was higher in strict vegetarians when compared to lacto-ovo-vegetarians and omnivores. At the genus level, strict vegetarians had a higher Prevotella abundance and Prevotella/Bacteroides ratio than the other groups. They also had a lower proportion of Faecalibacterium than lacto-ovo-vegetarians, and both vegetarian groups had higher proportions than did omnivores. Succinivibrio and Halomonas from the Proteobacteria phylum were overrepresented in omnivores. The omnivorous group showed higher values of anthropometric data, insulin, HOMA-IR, and a worse lipid profile. Inflammatory markers exhibited a gradual and significant increase from the vegetarians and lacto-ovo-vegetarians to the omnivorous group.CONCLUSIONS: There are differences in gut microbiota composition of individuals with distinct dietary habits, who differ according to their inflammatory and metabolic profiles. Based on the findings relative to bacteria abundances and on their recognized actions in the metabolism, we suggest that exposure to animal foods may favor an intestinal environment which could trigger systemic inflammation and insulin resistance-dependent metabolic disorders.

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09:44

An ovo-vegetarian diet is beneficial for long-term blood pressure control and prevention of hypertension in females. GreenMedInfo

PMID:  Public Health. 2017 Sep 25 ;153:70-77. Epub 2017 Sep 25. PMID: 28957713 Abstract Title:  Ovo-vegetarian diet is associated with lower systemic blood pressure in Taiwanese women. Abstract:  OBJECTIVE: This study was designed to investigate blood pressure (BP) profiles among Taiwanese women with different dietary patterns.STUDY DESIGN: Cross-sectional study.METHODS: A total of 269 non-hypertensive Taiwanese women, 40 years of age or older, were surveyed using structured questionnaires, and measurements of BP and physiological parameters were made. To assess differences among vegans, ovo-vegetarians, and meat eaters in terms of BP, demographic, and health behavior data, the chi-squared and Fisher's exact tests were employed for categorical variables, and analysis of variance and independent t-tests were performed for continuous variables. Multiple regression analysis was used to examine the relationship between BP and dietary patterns while controlling for potential confounding factors.RESULTS: A significant difference was found among the three test groups in terms of age, education, employment, stress, and waist-hip ratio. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) significantly differed among the three groups. After controlling for age, body weight, waist circumference, and hip circumference, the three groups were observed to be a significant risk factor of the SBP and DBP. The SBP and DBP of the ovo-vegetarian group were significantly lower than those of the meat-eater group. No significant differences were found between the vegan and meat-eater groups in terms of SBP and DBP.CONCLUSION: Dietary pattern is a likely risk factor for SBP and DBP outcomes in Taiwanese women. In particular, the SBP and DBP of ovo-vegetarians are the lowest among the values observed for all dietary patterns. This finding suggests that an ovo-vegetarian diet is beneficial for long-term BP control and prevention of hypertension in females.

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09:11

Vegetarian diets show as protective role against breast cancer risk. GreenMedInfo

PMID:  BMC Public Health. 2017 Oct 10 ;17(1):800. Epub 2017 Oct 10. PMID: 29017525 Abstract Title:  Is vegetarian diet associated with a lower risk of breast cancer in Taiwanese women? Abstract:  BACKGROUND: Studies on the relationship between vegetarian diet and breast cancer in Asian populations are limited. This study aimed to investigate the relationship between vegetarian diet, dietary patterns, and breast cancer in Taiwanese women.METHODS: This case-control study compared the dietary patterns of 233 breast cancer patients and 236 age-matched controls. A questionnaire about vegetarian diets and 28 frequently-consumed food items was administered to these 469 patients in the surgical department of Taipei Tzu Chi Hospital. Serum biochemical status was also examined.RESULTS: There were no significant differences between the two groups for age, education, family history, oral contraceptive usage, or regular exercise. However, the cancer group presented with both a higher body mass index and an older age of primiparity (P 

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08:39

Fecal Transplants for Allergies, Autism, and Autoimmune Disease GreenMedInfo

At first glance, fecal microbiota transplantation (FMT) appears to be a far-fetched procedure devised as a slapstick plot for a sit-com series. However, this innovative technique may revolutionize the future of medical treatments for a host of maladies including autoimmune and allergic diseases as well as autism spectrum disorder.

 

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08:39

There is some evidence that meditation is beneficial in improving quality of life in asthma patients. GreenMedInfo

PMID:  J Asthma. 2017 Aug 30:0. Epub 2017 Aug 30. PMID: 28853958 Abstract Title:  Meditation for asthma: Systematic review and meta-analysis. Abstract:  OBJECTIVE: To conduct a comprehensive review and meta-analysis of the effectiveness of meditation on a variety of asthma outcomes.METHODS: We searched MEDLINE, EMBASE, CINAHL, PsycINFO and AMED in June 2016 to identify randomised controlled trials (RCTs) investigating the effectiveness of meditation in adults with asthma. No restriction was put on language or year of publication. Study quality was assessed using The Cochrane Risk of Bias Assessment Tool. Meta-analysis was carried out using RevMan 5.3.RESULTS: Four RCTS involving 201 patients met the inclusion criteria. Quality of studies was inconsistent with only one study reporting adequate allocation concealment. Disease-specific quality of life was assessed in two trials; a pooled result involving 62 intervention and 65 control participants indicated a significant improvement in quality of life in the meditation group compared to the control group (SMD 0.40, 95% CI 0.05 to 0.76). A pooled result from all four studies indicated the uncertain effect of meditation in forced expiratory volume in one second (FEV1) (SMD -0.67, 95% CI -2.17 to 0.82). Results from the individual trials suggest that meditation may be helpful in reducing perceived stress and the use of short-term rescue medication.CONCLUSION: Our review suggests that there is some evidence that meditation is beneficial in improving quality of life in asthma patients. As two out of four studies in our review were of poor quality, further trials with better methodological quality are needed to support or refute this finding.

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08:35

This hypothesizes that the cumulative effects of a regular meditation practice may help to slow the epigenetic clock. GreenMedInfo

PMID:  Psychoneuroendocrinology. 2017 Nov ;85:210-214. Epub 2017 Aug 31. PMID: 28889075 Abstract Title:  Epigenetic clock analysis in long-term meditators. Abstract:  In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and meditation-nave controls to estimate their Intrinsic Epigenetic Age Acceleration (IEAA), using Horvath's calculator. IEAA was similar in both groups. However, controls showed a different IEAA trajectory with aging than meditators: older controls (age52) had significantly higher IEAAs compared with younger controls (age

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08:26

Mindfulness meditation has prominent effects on psychological aspects on living with chronic pain, improving depression and quality of life. GreenMedInfo

PMID:  Curr Opin Obstet Gynecol. 2017 Sep 28. Epub 2017 Sep 28. PMID: 28961631 Abstract Title:  Does mindfulness meditation improve chronic pain? A systematic review. Abstract:  PURPOSE OF REVIEW: Psychological factors are associated with chronic pain. Mindfulness meditation may ameliorate symptoms. The objective was to evaluate the effects of mindfulness meditation in chronic pain.RECENT FINDINGS: A systematic search of four databases identified 534 citations; 13 Randomised controlled trials satisfied the inclusion criteria. Mindfulness meditation significantly reduced depression [Standardised mean difference (SMD) -0.28; 95% confidence interval (CI) -0.53, -0.03; P=0.03; I=0%]. For affective pain (SMD -0.13; 95% CI -0.42, 0.16; I=0%), sensory pain (SMD -0.02; 95% CI -0.31, 0.27; I=0%) and anxiety (SMD -0.16; 95% CI -0.47, 0.15; I=0%) there was a trend towards benefit with intervention. Quality of life items on mental health (SMD0.65; 95% CI -0.27, 1.58; I=69%), physical health (SMD 0.08; 95% CI -0.40, 0.56; I=32%) and overall score (SMD 0.86, 95% CI -0.06, 1.78; I=88%) improved with mindfulness meditation.SUMMARY: Mindfulness meditation has most prominent effect on psychological aspects on living with chronic pain, improving associated depression and quality of life.

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08:17

Studies of meditation suggest a possible benefit on cardiovascular risk. GreenMedInfo

PMID:  J Am Heart Assoc. 2017 Sep 28 ;6(10). Epub 2017 Sep 28. PMID: 28963100 Abstract Title:  Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association. Abstract:  Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have reported on the benefits of meditation. Meditation instruction and practice is widely accessible and inexpensive and may thus be a potential attractive cost-effective adjunct to more traditional medical therapies. Accordingly, this American Heart Association scientific statement systematically reviewed the data on the potential benefits of meditation on cardiovascular risk. Neurophysiological and neuroanatomical studies demonstrate that meditation can have long-standing effects on the brain, which provide some biological plausibility for beneficial consequences on the physiological basal state and on cardiovascular risk. Studies of the effects of meditation on cardiovascular risk have included those investigating physiological response to stress, smoking cessation, blood pressure reduction, insulin resistance and metabolic syndrome, endothelial function, inducible myocardial ischemia, and primary and secondary prevention of cardiovascular disease. Overall, studies of meditation suggest a possible benefit on cardiovascular risk, although the overall quality and, in some cases, quantity of study data are modest. Given the low costs and low risks of this intervention, meditation may be considered as an adjunct to guideline-directed cardiovascular risk reduction by those interested in this lifestyle modification, with the understanding that the benefits of such intervention remain to be better established. Further research on meditation and cardiovascular risk is warranted. Such studies, to the degree possible, should utilize randomized study design, be adequately powered to meet the primary study outcome, strive to achieve low drop-out rates, include long-term follow-up, and be performed by those without inherent bias in outcome.

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08:16

Sunspots on Skin: Causes, Home Remedies and Prevention Healthy and Natural World

Aging causes many changes to the skin, and the appearance of sunspots on the skin is just one of these changes. Sunspots are changes in the skins pigmentation and generally occur on areas of the skin that has been exposed to the sun. Therefore, sunspots on the face, back of the hands, arms, and shoulders are very common among older people.

For many people, patches of uneven skin tone caused by the sun are unsightly marks or blemishes on the skin. Therefore, you may want to know how to get rid of sunspots naturally without using harsh treatments. Some natural remedies that help to reduce the appearance of sunspots include lemon juice or apple cider vinegar which contain compounds found in many commercially available skin-lightening products.

Because both commercial and natural treatments for sunspots take patience and perseverance to work, preventing sunspots is essential. You can help prevent sunspots by using a high SPF sunscreen or covering exposed areas of skin when you are in the sun. This will also help prevent skin damage that could lead to skin cancer or signs of premature aging.

In this article, you will learn about what exactly causes sunspots on your skin and how to tell sun spots apart from freckles. The article also examines various natural home remedies to treat sunspots on your face, hands, or arms.

What are Sunspots on Skin?

Sunspots on the skin are medically referred to as solar lentigines. They are usually caused by exposure to the sun and appear as darkened patches of skin. Many people refer to skin sunspots as liver spots from the mistaken view that they are caused by liver malfunction. However, according to Dr. David Swanson on MedlinePlus, sunspots have nothing to do with your liver health.1 Some people call sunspots old age spots, age spots, or senile freckle.

Sunspots can look like large freckles and come in various shades and sizes. Consultant dermatologist, Dr. Bob Chan says that solar lentigines or sunspots are harmless and may range in color from light tan to dark brown or even black. Sunspots also vary in size some can be as small as a few millimeters or be as large as several centimeters in diameter and may feel like a slightly raised bump on the skin.

Most dermatologists say that sunspots generally appear when a person is over 40 years old and they mostly affect fair-skinned people, although they are also not uncommon in darker-skinned people. Common places where sunspots appear are on your face, forehead, back of your hands, and shoulders. If you have a bald head, then sunspots may show up on your scalp.

What Causes Sunspots on Skin and Face?

The small dark sunspots on your skin are the result of ultraviolet light from the suns rays causing...

08:05

Music had beneficial effects on seizure frequency in institutionalized subjects with severe intellectual disability and drug-resistant epilepsy. GreenMedInfo

PMID:  Psychiatr Danub. 2017 Sep ;29(Suppl 3):399-404. PMID: 28953798 Abstract Title:  Effects of music on seizure frequency in institutionalized subjects with severe/profound intellectual disability and drug-resistant epilepsy. Abstract:  BACKGROUND: Approximately one-third of patients with epilepsy continue to experience seizures despite adequate therapy with antiepileptic drugs. Drug-resistant epilepsy is even more frequent in subjects with intellectual disability. As a result, several non-pharmacological interventions have been proposed to improve quality of life in patients with intellectual disability and drug-resistant epilepsy. A number of studies have demonstrated that music can be effective at reducing seizures and epileptiform discharges. In particular, Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal EEG discharges and recurrence of clinical seizures in patients with intellectual disability and drug-resistant epilepsy as well. The aim of this study is to investigate the influence of Mozart's music on seizure frequency in institutionalized epileptic subjects with profound/severe intellectual disability.SUBJECTS AND METHODS: Twelve patients (10 males and 2 females) with a mean age of 21.6 years were randomly assigned to two groups in a cross-over design; they listened to Mozart K448 once a day for six months.RESULTS: A statistically significant difference was observed between the listening period and both baseline and control periods. During the music period, none of the patients worsened in seizure frequency; one patient was seizure-free, five had a greater than 50% reduction in seizure frequency and the remaining showed minimal (N=2) or no difference (N=4). The average seizure reduction compared to the baseline was 20.5%. Our results are discussed in relation to data in the literature considering differences in protocol investigation.CONCLUSIONS: Music may be considered a useful approach as add-on therapy in some subjects with profound intellectual disability and drug-resistant epilepsy and can provide a new option for clinicians to consider, but further large sample, multicenter studies are needed to better understand the characteristics of responders and non-responders to this type of non-pharmacological intervention.

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07:55

You Embody What Your Ancestors Experienced 14 Generations Ago Natural Blaze

epigenetics

By Aaron KeselNatural Blaze

Researchers have discovered that environmental genetic changes (epigenetics) can be passed down for an incredible 14 generations in an animal  the largest span ever observed in a living organism.

A team led by scientists from the European Molecular Biology Organisation (EMBO) in Spain took genetically engineered nematode roundworms called C. elegans that carry a transgene for a fluorescent protein. Which when activated, this gene made the worms glow bright under the ultraviolet light.

Then, they changed the temperature of their containers. Keeping the nematodes at (68 F), they measured low activity of the transgene which as a result the worms hardly glowed at all.

Researchers then changed the control in the experiment moving the worms to a warmer climate of 77 F, they suddenly lit up like Christmas trees, which meant the fluorescence gene had become less dormant.

...

07:50

These findings bring converging evidence on the idea that binaural beats act as a neural entrainment technique. GreenMedInfo

PMID:  Exp Brain Res. 2017 Jul ;235(7):2125-2131. Epub 2017 Apr 13. PMID: 28409319 Abstract Title:  The effect of gamma-enhancing binaural beats on the control of feature bindings. Abstract:  Binaural beats represent the auditory experience of an oscillating sound that occurs when two sounds with neighboring frequencies are presented to one's left and right ear separately. Binaural beats have been shown to impact information processing via their putative role in increasing neural synchronization. Recent studies of feature-repetition effects demonstrated interactions between perceptual features and action-related features: repeating only some, but not all features of a perception-action episode hinders performance. These partial-repetition (or binding) costs point to the existence of temporary episodic bindings (event files) that are automatically retrieved by repeating at least one of their features. Given that neural synchronization in the gamma band has been associated with visual feature bindings, we investigated whether the impact of binaural beats extends to the top-down control of feature bindings. Healthy adults listened to gamma-frequency (40 Hz) binaural beats or to a constant tone of 340 Hz (control condition) for ten minutes before and during a feature-repetition task. While the size of visuomotor binding costs (indicating the binding of visual and action features) was unaffected by the binaural beats, the size of visual feature binding costs (which refer to the binding between the two visual features) was considerably smaller during gamma-frequency binaural beats exposure than during the control condition. Our results suggest that binaural beats enhance selectivity in updating episodic memory traces and further strengthen the hypothesis that neural activity in the gamma band is critically associated with the control of feature binding.

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07:41

These results demonstrated that atractylenolide I has significant antitumor activity in lung carcinoma cells. GreenMedInfo

PMID:  Molecules. 2013 Oct 29 ;18(11):13357-68. Epub 2013 Oct 29. PMID: 24172243 Abstract Title:  Anti-tumor effects of atractylenolide I isolated from Atractylodes macrocephala in human lung carcinoma cell lines. Abstract:  Atractylenolide I (ATL-1) is the major sesquiterpenoid of Atractylodes macrocephala. This study was designed to investigate whether ATL-1 induced apoptosis in A549 and HCC827 cells in vitro and in vivo. In our results, ATL-1 significantly decreased the percentage of in vitro viability, in a dose-dependent manner. In addition, DAPI staining and flow cytometry tests demonstrated the induction of apoptosis by ATL-I. Western blot analysis indicated that the protein levels of caspase-3, caspase-9 and Bax were increased in A549 and HCC827 cells after ATL-I exposure; to the contrary, the expressions of Bcl-2, Bcl-XL were decreased after treatment with ATL-1. In the in vivo study, ATL-I effectively suppressed tumor growth (A549) in transplanted tumor nude mice with up-regulation of caspase-3, caspase-9, and Bax and down-regulation of Bcl-2 and Bcl-XL. In conclusion, our results demonstrated that ATL-I has significant antitumor activity in lung carcinoma cells, and the possible mechanism of action may be related to apoptosis induced by ATL-I via a mitochondria-mediated apoptosis pathway.

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07:26

These findings suggest that combination of two or more herbs might be used as a promising source of natural antioxidants. GreenMedInfo

PMID:  Nat Prod Commun. 2013 Sep ;8(9):1321-4. PMID: 24273876 Abstract Title:  Chemical composition and synergistic antioxidant activities of essential oils from Atractylodes macrocephala and Astragalus membranaceus. Abstract:  Chemical composition of the essential oils derived from Atractylodes macrocephala (AMA), Astragalus membranaceus (AME) and AMA-AME herb pair was investigated using gas chromatography-mass spectrometry (GC-MS). Antioxidant activities were evaluated by 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and Trolox equivalent antioxidant capacity (TEAC) assays. Forty-five, ten and forty-three components were identified in AMA, AME and AMA-AME essential oils, respectively. AMA-AME essential oil exhibited a significantly higher radical scavenging capacity than the theoretical sum of those of the respective herb essential oils (P

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07:14

Polyacetylenes might greatly contribute to the anti-inflammatory activity of the rhizomes of A. macrocephala. GreenMedInfo

PMID:  J Ethnopharmacol. 2014 Feb 3 ;151(2):791-9. Epub 2013 Dec 1. PMID: 24296088 Abstract Title:  Bioactivity-guided isolation of polyacetylenes with inhibitory activity against NO production in LPS-activated RAW264.7 macrophages from the rhizomes of Atractylodes macrocephala. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: The rhizome of Atractylodes macrocephala (Compositae) is one of the most well-known traditional Chinese medicine in China, Japan and Korea, which has a long history of use for the treatment of splenic asthenia, edema, anorexia, and excessive perspiration, etc. As active compounds of anti-inflammatory activity of this medicinal plant have not been fully elucidated, the aim of this study was to isolate and identify the active constituents inhibiting nitric oxide (NO) production from the rhizomes of A. macrocephala.MATERIALS AND METHODS: Inhibitory activity against NO production in lipopolysaccharide-activated RAW264.7 macrophages was evaluated by Griess reaction. Fifteen polyacetylenes were isolated from the active ethyl acetate extract using activity-guided screening. The structures of all compounds were elucidated by spectroscopic methods and comparison with published data. The compounds were further tested for their inhibitory activity against NO production.RESULTS: Seven new polyacetylenes, named atractylodemaynes A-G (1-7), along with eight known ones (8-15) were isolated. Compound 14 was isolated for the first time from the rhizomes of A. macrocephala. The study showed that the tested compounds exhibited inhibitory activity against NO production in a dose-dependent manner. Among them, compounds 10, 11 and 12 had relatively stronger inhibitory effect with IC50 values of 28, 23 and 19M, respectively.CONCLUSION: The results demonstrated that the polyacetylenes might greatly contribute to the anti-inflammatory activity of the rhizomes of A. macrocephala.

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07:03

This suggests the potential of A. macrocephala to cure intestinal disorders characterized by injury and ineffective repair of the intestinal mucosa. GreenMedInfo

PMID:  J Ethnopharmacol. 2015 Jan 15 ;159:23-35. Epub 2014 Nov 12. PMID: 25446597 Abstract Title:  Atractylodes macrocephala Koidz stimulates intestinal epithelial cell migration through a polyamine dependent mechanism. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Atractylodes macrocephala Koidz (AMK), a valuable traditional Chinese herbal medicine, has been widely used in clinical practice for treating patients with disorders of the digestive system. AMK has shown noteworthy promoting effect on improving gastrointestinal function and immunity, which might represent a promising candidate for the treatment of intestinal mucosa injury. The aim of this study was to investigate the efficacy of AMK on intestinal mucosal restitution and the underlying mechanisms via intestinal epithelial (IEC-6) cell migration model.MATERIALS AND METHODS: A cell migration model of IEC-6 cells was induced by a single-edge razor blade along the diameter of the cell layers in six-well polystyrene plates. After wounding, the cells were grown in control cultures and in cultures containing spermidine (5M, SPD, reference drug), alpha-difluoromethylornithine (2.5mM, DFMO, polyamine inhibitor), AMK (50, 100, and 200mg/L), DFMO plus SPD and DFMO plus AMK for 12h. The polyamines content was detected by high-performance liquid chromatography (HPLC) with pre-column derivatization. The Rho mRNAs expression levels were assessed by Q-RT-PCR. The Rho and non-muscle myosin II proteins expression levels were analyzed by Western blot. The formation and distribution of non-muscle myosin II stress fibers were monitored with immunostaining techniques using specific antibodies and observed by confocal microscopy. Cell migration assay was carried out using inverted microscope and the Image-Pro Plus software. All of these indexes were used to evaluate the effectiveness of AMK.RESULTS: (1) Treatment with AMK caused significant increases in cellular polyamines content and Rho mRNAs and proteins expression levels, as compared to control group. Furthermore, AMK exposure increased non-muscle myosin II protein expression levels and formation of non-muscle myosin II stress fibers, and resulted in an acceleration of cell migration in IEC-6 cells. (2) Depletion of cellular polyamines by DFMO resulted in a decrease of cellular polyamines levels, Rho mRNAs and proteins expression, non-muscle myosin II protein formation and distribution, thereby inhibiting IEC-6 cell migration. AMK not only reversed the inhibitory effects of DFMO on the polyamines content, Rho mRNAs and proteins expression, non-muscle myosin II protein formation and distribution, but also restored cell migration to control levels.CONCLUSIONS: The results obtained from this study revealed that AMK significantly stimulates the migration of IEC-6 cells through a polyamine dependent...

06:52

Polysaccharide from the rhizome of Atractylodes macrocephala can significantly improve disordered intestinal flora. GreenMedInfo

PMID:  Evid Based Complement Alternat Med. 2014 ;2014:926381. Epub 2014 Nov 19. PMID: 25505927 Abstract Title:  The Metabolism of Polysaccharide from Atractylodes macrocephala Koidz and Its Effect on Intestinal Microflora. Abstract:  An active polysaccharide from the rhizome of Atractylodes macrocephala Koidz (PAM) was identified to improve and adjust disordered intestinal flora. High-performance gel permeation chromatography (HPGPC) and gas chromatography-mass spectrometry (GC-MS) were employed to identify the components of PAM as rhamnose, glucose, mannose, xylose, and galactose at a ratio of 0.03:0.25:0.15:0.41:0.15. PAM metabolized in gastrointestinal tract when incubated with artificial gastric and intestinal juices. Anaerobic incubation of PAM on intestinal flora confirmed that PAM promoted the ability of intestinal bacteria to digest reducing sugar. Based on theShannon index and similarity coefficient index of enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR) fingerprinting of the total intestinal bacteria DNA, we concluded that PAM can significantly improve disordered intestinal flora and may be used as an oral adjuvant to regulate intestinalflora.

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06:44

A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. GreenMedInfo

PMID:  Biomol Ther (Seoul). 2015 Jan ;23(1):26-30. Epub 2015 Jan 1. PMID: 25593640 Abstract Title:  Atractylochromene Is a Repressor of Wnt/-Catenin Signaling in Colon Cancer Cells. Abstract:  Wnt/-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated -catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes. In this study, we identified an inhibitor of -catenin dependent Wnt pathway from rhizomes of Atractylodes macrocephala Koidzumi (Compositae). The active compound was purified by activity-guided purification and the structure was identified as 2,8-dimethyl-6-hydroxy-2-(4-methyl-3-pentenyl)-2H-chromene (atractylochromene, AC). AC suppressed -catenin/T-cell factor transcriptional activity of HEK-293 reporter cells when they were stimulated by Wnt3a or inhibitor of glycogen synthase kinase-3. AC down-regulated the nuclear level of -catenin through the suppression of galectin-3 mediated nuclear translocation of-catenin in SW-480 colon cancer cells. Furthermore, AC inhibits proliferation of colon cancer cell. Taken together, AC from A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.

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06:34

This study indicates that Atractylodes macrocephala has a potential for stimulating mitochondrial function and energy metabolism in muscle. GreenMedInfo

PMID:  Evid Based Complement Alternat Med. 2015 ;2015:643654. Epub 2015 Nov 4. PMID: 26617661 Abstract Title:  The Roots of Atractylodes macrocephala Koidzumi Enhanced Glucose and Lipid Metabolism in C2C12 Myotubes via Mitochondrial Regulation. Abstract:  The root of Atractylodes macrocephala Koidzumi (Atractylodis Rhizoma Alba, ARA) is a Traditional Korean Medicine and has been commonly used for weight control. Mitochondrial dysfunction appears to be a key contributor to insulin resistance, and therefore mitochondrial targeting drugs represent an important potential strategy for the treatment of insulin resistance and obesity. In this study, the authors investigated the regulatory effects of ARA on mitochondrial function with respect to the stimulation of glucose and lipid metabolism in C2C12 myotubes. After differentiating C2C12 myotubes, cells were treated with or without different concentrations (0.2, 0.5, and 1.0mg/mL) of ARA extract. ARA extract significantly increased the expression of peroxisome proliferator-activated receptor coactivator 1 alpha (PGC1) and the downregulations of its targets, nuclear respiratory factor-1 (NRF-1), transcription factor A (TFAM), and total ATP content in C2C12 myotubes. ARA extract also increased the expressions of PGC1 activator and of the metabolic sensors, AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase and sirtuin (SIRT) 1. Furthermore, it significantly increased glucose uptake by enhancing glucose consumption and subsequently decreased FFAcontents and increased carnitine palmitoyltransferase (CPT) 1b expression. Our study indicates that ARA has a potential for stimulating mitochondrial function and energy metabolism in muscle.

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06:28

Our Movement Has Failed (So Far) Heres How To Change That Mad In America

Our movement is brimming with great ideas. From the inspiring potential of Open Dialogue to the simple hope of support for medication withdrawal, from the vision of the Hearing Voices Movement to the growing research on peer supports, nutrition, and trauma informed care, we have wonderful solutions and real possibilities for change. And we have powerful outspoken champions pushing hard across the country and around the world working to put these visions into reality.

We also have common sense on our side, as our growing voice for sanity in mental health care resonates throughout society. Skepticism about forced treatment has deep roots in the US since One Flew Over The Cuckoos Nest broke the taboo about psychiatric violence. Calls for greater holistic and collaborative approaches resound today throughout all medicine, with a steady stream of research endorsing more humane and people-centered healthcare. Critiques of Big Pharma are widespread in the media and an ongoing dimension of our healthcare debates; more and more people have experienced firsthand the broken promises of psychiatrys pill promotion. When I talk with people around the country and US people who have been in the system, family members, professionals, and yes even many psychiatrists and researchers at institutions ranging from Harvard Medical School to Oregon Health Sciences University there is a clear level of agreement with our ideas, that more compassion and listening, and less medical authority and pharmaceuticals, are needed.

Weve all been busy pushing hard for these alternatives, these programs and reforms.

And were also going to fail.

Fail, that is, unless we completely change our strategy. Thats right, nothing is going to change unless we change how we are doing this work.

Either we realize the truth of this that we are going to fail without a new strategy or we risk betraying the trust and hope that people have put into us as leaders for reform. We risk becoming a professional complainer class funded and salaried advocates calling for change who have no real incentive to switch strategies when the reforms fail, because the money and influence for being a professional complainer continue to flow.

I have no intention ten years from now of writing another essay or making another speech or doing another training or making another film about how the system has to change. Im just not interested. I dont want to be a professional advocate and reformer.

I WANT TO WIN.

If you think its not possible, if you think a real total transformation of our mental health system is not possible, then you have no business advocating for change in the first place. Its hypocritical, and you should get out of the...

06:16

Atractylenolide I could be used for leukemia treatment in the future. GreenMedInfo

PMID:  Bioorg Med Chem Lett. 2016 Apr 15 ;26(8):1905-9. Epub 2016 Mar 8. PMID: 26988300 Abstract Title:  Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells. Abstract:  Atractylodes macrocephula Koidz (A. macrocephula, also known as Baizhu) is an important ingredient in several traditional Chinese herb complexes for the treatment of abdominal pain and gastroenterology diseases for thousands of years. We previously demonstrated the induction of ROS-mediated apoptosis by methanol extract of A. macrocephula in human leukemia cells. After purification and assessment of those active compounds from A. macrocephula ethanol extracts, in this study, we focused on the major active compound, atractylenolide I (ATL-I). Through MTT assay and morphology observation, we found cytotoxic effect of ATL-I in human K562 chronic myeloblastic leukemia (CML), U937 acute myeloblastic leukemia (AML) and Jurkat T lymphoma cells. In addition, ATL-I-induced apoptosis was demonstrated by sub G1 and fragmented chromosomal DNA detection using flow cytometry, enzyme-linked immunosorbent assay (ELISA) and agarose electrophoresis. Finally, we found ATL-I also induced caspase-3 and caspase-9 activation through the detection of procaspase-3, procaspase-9 and caspase-3 substrate poly(ADP-ribose) polymerase (PARP) by immunoblotting. Interestingly, we found that ATL-I induced not only apoptosis but also differentiation, as upregulation of CD14 and CD68 surface markers and increase of phagocytosis ability were discovered in ATL-I-treated K562 CML and U937 AML cells. Our study thus suggests the potential of developing new leukemia therapies by using ATL-I for leukemia treatment in the future.

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06:02

Seeing These Cute Baby Animals Will Make Your Entire Day Healthy Holistic Living

Humans are hardwired to find babies adorable. Its natures way of ensuring that well take care of our own, and keep the animal population on earth going. Its this biological need that causes us to awwww every time we look at a photo of a baby. That warm, fuzzy feeling...

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05:58

Inflammatory inhibitory activity of sesquiterpenoids from Atractylodes macrocephala rhizomes. GreenMedInfo

PMID:  Chem Pharm Bull (Tokyo). 2016 ;64(5):507-11. PMID: 27150484 Abstract Title:  Inflammatory Inhibitory Activity of Sesquiterpenoids from Atractylodes macrocephala Rhizomes. Abstract:  Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7,11-diol (3), along with eleven known compounds (4-14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1-3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC50 values of 48.60.5, 46.43.2, and 32.32.9M, respectively.

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05:42

Whooping Cough Outbreaks Traced Back to Vaccine Failure Vaccine Impact

pertussis-vaccine-failure

Whooping Cough Reemergence Traced Back to Vaccine Failure and Flawed Assumptions

by Dr. Mercola

The pertussis (whooping cough) vaccine is included as a component in combination shots that include tetanus and diphtheria (DPT, DTaP, Tdap) and some pertussis-containing shots now also include polio, hepatitis B and/or Haemophilus Influenza B (Hib). Whole cell pertussis vaccines in DPT, used in the U.S. from 1949 until the late 90s, were estimated to be between 30 and 85 percent effective, depending upon the type of DPT and vaccine manufacturer, with protection lasting only two to five years. [1]

The DPT vaccine was highly reactive and carried a high risk of serious allergic reactions and brain inflammation leading to permanent brain damage, as detailed in the groundbreaking 1985 book DPT: A Shot in the Dark, co-authored by Barbara Loe Fisher, cofounder of the National Vaccine Information Center.

DTaP shots which contain the less reactive acellular pertussis vaccine licensed for infants in the United States in 1996 are given five times to children under age 6, with additional Tdap booster doses recommended for teenagers and adults. Since the late 1980s, CDC data shows that kindergarten children in the U.S. have maintained a high vaccination rate with four to five DPT shots and, today, more than 94 percent of kindergarten children have had four to five acellular DTaP vaccines.

Very high pertussis vaccination rates in the U.S. and many other countries for the past several decades should be more than sufficient to achieve vaccine-acquired herd immunity, if the theory of vaccine-acquired herd immunity is correct. [2] Yet, despite high vaccine coverage, statistics show reported whooping cough cases continue to rise. So, whats really going on?

Studies Show Pertussis Vaccine Doesnt Work

Scientific findings suggest whooping cough vaccines both whole cell and acellular fail to provide adequate protection against infection and the transmission of infection. There are indications that subclinical and undiagnosed pertussis infections have been occurring since the early 1980s among both vaccinated and unvaccinated persons.

Now, a recently published scientific study [3,4] confirms the acellular whooping cough vaccine does not work as expected and...

05:42

Atractylenolide-I might be a potential therapeutic agent in the treatment of ovarian cancer. GreenMedInfo

PMID:  Med Sci Monit. 2017 Jan 31 ;23:571-579. Epub 2017 Jan 31. PMID: 28141785 Abstract Title:  Anti-Tumor Effects of Atractylenolide-I on Human Ovarian Cancer Cells. Abstract:  BACKGROUND The aim of this study was to investigate the effects of Atractylenolide-I (AT-I), a naturally occurring sesquiterpene lactone isolated from Atractylodes macrocephala Koidz, on human ovarian cancer cells. MATERIAL AND METHODS The viability and anchorage-independent growth of ovarian cancer cells were evaluated using MTT and colony formation assay, respectively. Cell cycle and apoptosis were detected with flow cytometry analysis. The level of cyclin B1 and CDK1 was measured using qPCR and ELISA analysis. The expression of Bax, cleaved caspase-9, cleaved caspase-3, cytochrome c, AIF, and Bcl-2, and phosphorylation level of PI3K, AKT, and mTOR were determined with Western blot analysis. RESULTS AT-I decreased the cell viability and suppressed anchorage-independent growth of A2780 cells. Cell cycle was arrested in G2/M phase transition by AT-I treatment, which was related to decreased expression of cyclin B1 and CDK1 in a dose-dependent manner. In addition, the treatment induced apoptosis, as shown by up-regulation of Bax, cleaved caspase-9, cleaved caspase-3, and cytosolic release of cytochrome c and AIF, and down-regulation of Bcl-2, in a dose-dependent manner. Then, the effects of AT-I on PI3K/Akt/mTOR pathways were examined to further investigate the underlying anti-cancer mechanism of AT-I, and the results showed that treatment with AT-I significantly decreased the phosphorylation level of PI3K, Akt, and mTOR. CONCLUSIONS This study demonstrated that AT-I induced cell cycle arrest and apoptosis through inhibition of PI3K/Akt/mTOR pathway in ovarian cancer cells. These results suggest that AT-I might be a potential therapeutic agent in the treatment of ovarian cancer.

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05:39

How Your Shampoo Can Make You Sick Healthy Holistic Living

This article is shared with permission from our friends at Dr. Mercola. You may be mistakenly comforted by the perceived oversight by the U.S. Food and Drug Administration (FDA) over chemicals used in the manufacture of everyday products. For instance, the FDA prohibits the use of mercury, chloroform and nine other substances in...

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05:27

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse. GreenMedInfo

PMID:  Gut Liver. 2017 Sep 15 ;11(5):655-666. PMID: 28651306 Abstract Title:  Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse. Abstract:  Background/Aims: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) may be better than sulfasalazine for treating this disease because these extracts can promote additional regeneration.Methods: Murine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a lipopolysaccharide (LPS)-induced challenge. Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were administered for 2 weeks before DSS administration.Results: In vitro studies demonstrated that AM or TH treatment reduced LPS-induced COX-2 and tumor necrosis factor- mRNA levels but increased heme oxygenase-1 (HO-1). Oral preadministration of AM and TH rescued mice from DSS-induced colitis by inhibiting inflammatory mediators via inactivated extracellular signal regulated kinase and repressed nuclear factor B and signal transducer and activator of transcription 3, but the effect was weaker for sulfasalazine than that for the extracts. Anti-inflammatory activities occurred via the inhibition of macrophage and T lymphocyte infiltrations. Unlike sulfasalazine, which did not induce HO-1, TH extracts afforded significant HO-1 induction.Conclusions: Because the AM or TH extracts were far superior in preventing DSS-induced colitis than sulfasalazine, AM or TH extracts can be considered natural agents that can prevent IBD relapse.

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05:25

14 Easy Green DIY Life Hacks for a Clutter-Free Kitchen Healthy Holistic Living

Is a messy kitchen getting you down? Thats no surprise. A study of 30 women recently confirmed that people who perceive their kitchens to be cluttered and stressful places experience more depressed moods and higher stress levels throughout the day than people with less cluttered kitchens (1). Perhaps its time to make kitchen...

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05:11

28 Delicious Fall Recipes with No Dairy, Gluten or Sugar Healthy Holistic Living

This amazing article was written by Nicole, a holistic nutritionist with a strong belief that it is possible for everyone to discover how good their body is designed to feel. Nicole works in partnership with her clients to achieve a lifestyle that is both balanced, fulfilling and nourishing. Go check...

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04:54

The Importance of Proper Form: 15 Dangerous Workout Mistakes Healthy Holistic Living

If you have ever started a fitness routine that finally works, you probably know that distinct moment when you realize its not only giving you results but feels good, too! Far too often, though, people jump right into an online routine or try keeping up with a group class. While...

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04:43

Thanks for the shout out! #vaccines weaken and damage the immune system making you more susceptible to disease! EVDN

https://www.google.com/amp/www.timesnownews.com/amp/health/article/ebola-two-experimental-vaccines-found-safe-effective-in-human-trial/105659#ampshare=http://www.timesnownews.com/health/article/ebola-two-experimental-vaccines-found-safe-effective-in-human-trial/105659

04:38

VACCINE EXEMPTION FORMS EVDN

http://experimentalvaccines.org/vaccine-exemption-forms/

04:24

Obamacare Reinterpreted? The Alliance for Natural Health

No, not by Congressby a Trump executive order signed today.

President Trump has signed an executive order expanding access to association health planspolicies that do not have to adhere to a number of Obamacare rules.

The idea, strongly supported by Sen. Rand Paul, is that individuals with a common profession or interest could band together and be counted as a large-group (equivalent to an employer) for health insurance purposes.

Individuals could thus opt out of the Obamacare plans theyre currently enrolled in, and presumably obtain lower rates when they buy into catastrophic or bare bones plans.  The consequence of the executive order could be a parallel, consumer-driven system, although one that could be reversed by the next president.

Association plans are regulated under the Employee Retirement Income Security Act (ERISA).  Because it will be under ERISA, it may turn out that this option is only open to employed workers, not to non-workers. We shall have to wait and see.

The great advantage here is that large-group plans are subject to fewer mandates than under Obamacare such as having to offer Essential Health Benefits.  Large-group plans also have more leeway in setting premiums, which can be based on the health of the group (which is barred under the ACA for small-group plans).  Associations that gain large-group status could therefore offer less expensive coverage if they were made up mainly of younger, healthier members.

Most association health plans now in place are considered small-group plans.

The National Association of Insurance Commissioners has gone on record in opposition, arguing that it would make insurance less available, make insurers less accountable, and prevent regulators from assisting consumers in their states. This not surprising. State officials do not welcome competition from insurance approved in other states.

It is also unclear if the executive order will withstand legal scrutiny and challenge. Congress could also undermine the effort by refusing to fund changes to existing law made by the executive order.

This is just the start of the process. Several federal agencies have been directed to write rules implementing the executive order, so there will be future opportunities for the public to weigh in on the new regulations. We will keep you posted on these developments.

 

 

03:59

A Door Opens for Insurance Coverage of Non-Opioid Pain Treatments The Alliance for Natural Health

Thirty-seven state attorneys general recently wrote to Americans Health Insurance Plans (AHIP), saying that the status quo is unacceptable. We agree. Action Alert!

The letter urges AHIP to encourage healthcare providers to prioritize non-opioid pain management optionssuch as physical therapy, acupuncture, chiropractic care, and massageover opioid prescriptions in the treatment of chronic pain.

Opioid addiction is killing people in startling numbersmore people each year than are killed in traffic accidents, and the single largest contributor to deaths among those younger than 50.

ANH agrees that insurers should rethink their policies and cover non-opioid pain treatments but we would add a number of other treatments to the list, including CBD oil, fish oil (omega-3 fatty acids produce cannabinoids naturally in the body), boswellia, white willow bark and other anti-inflammatories, as well as electrical and magnetic treatments.

This would of course save insurers and patients a lot of money. Opioid treatments can cost patients thousands of dollars a year. An overall economic analysis suggests that prescription opioid use disorders and overdoses cost the US $78 billion in 2013 alone. Natural medicine is of course far cheaperas long as Big Pharma isnt allowed to corner the fish oil market, as Amarin is currently trying to do.

Action Alert! Send a message to AHIP, urging their member companies to heed the state attorney generals message and begin covering natural approaches to pain control. Please send your message immediately.

 

03:56

Dont Turn Vitamins into Drugs The Alliance for Natural Health

We must keep the FDA from turning a vital nutrient over to Big Pharma. Action Alert!

An important study finds that carbidopa, a standard Parkinsons drug, irreversibly binds to and permanently deactivates pyridoxal-5-phosphate (P5P), a key form of vitamin B6 in the body. The authors describe the essential role P5P plays in the body: [P5P] is required for the function of over 300 enzymes and proteins. Virtually every major system of the body is impacted directly or indirectly by [it].

Youre not likely to hear from a conventional doctor how this drug destroys a vital nutrient in your body, just as youre unlikely to hear how a host of other drugs interfere with the bodys absorption of key vitamins and minerals. (The FDA hasnt approved alternative therapies for Parkinsons, such as focused ultrasound, even though it is approved for similar conditions.)

Actually, the FDA would prefer you to take your B6 in the form of a drug. You may recall the case of pyridoxamine, one of three bioavailable forms of vitamin B6. This vitamin has many health benefits; indeed, we could not live without B6. Notwithstanding, in 2009 the FDA banned the supplement form of pyridoxamine in response to a petition from a drug company, which wanted to use it in a drug formulation.

P5P faces a similar threat. The FDA is considering a petition from Medicure Pharma to ban P5P because the company wants to turn this crucial vitamin into a drug. This is especially scaryall forms of B6, natural or synthetic, must be converted to P5P for the body to use them. If the FDA approves the petition, anyone who is not able to convert synthetic B6 to P5P would have to rely solely on Medicures product to stay alive.

The FDA needs to know that we realize whats going on, and that consumers wont tolerate the loss of another vital nutrient, one that we would die without, to the pharmaceutical industry.

Action Alert! Write to the FDA and urge them not to grant Medicures petition to turn P5P into a drug. Please send your message immediately.

...

03:09

Sporebiotics: The Best Probiotics to Fight Chronic Illness and Boost Immune Tolerance Natural Blaze

By Anna Hunt

Spore-based probiotics may be some of the best probiotics available, according Dr. Dietrich Klinghardt, Ph.D. and founder of the Sophia Health Institute. This lesser-known supplement, called sporebiotics for short, supports a healthy gut and immune system function, and can help the body fight off environmental stressors that cause chronic health issues.

Sporebiotics are a group of gut microbes. They join 2,500+ other species of bacteria in the gut that work symbiotically with the human body and aid in healthy human function. What makes sporebiotics unique is their ability to benefit the immune system better than other probiotics.

Because of the sporebiotics unique abilities, scientists believe they may benefit people with health problems such as autism, neurological disorders, and immune-related diseases. In addition, spore-based probiotics may help fortify the body against environmental aggressors such as electromagnetic fields (EMFs), pesticides, and airborne pollutants.

Antibiotic-resistant Spore-based Probiotics

A microbiologist from Germany, Gunther Enderlein created spore-based probiotics in 1935. Essentially, these microorganisms consist of off-shoots of the microbe called bacillus. Scientists believe the subspecies bacillus subtilis is one of the most important and beneficial sporebiotics.

Unlike other probiotics, sporebiotics do not contain any live bacteria strains. They consist of the cell wall of bacillus spores. Therefore, they are not affected by antibiotics, which kill off both good and bad bacteria living in the body. Over-exposure to antibiotics found in foods, such as meats and dairy, has affected the gut microbiome of the typical Westerner. This is believed to be one of the main reasons why so many suffer from chronic il...

02:57

Study Exposes Dark Side of Coffee Cultivation in Uganda Natural Blaze

By Lauren Stralo, Lehigh University

Coffee represents a multi-hundred-billion dollar industry, consumed almost entirely by industrialized nations while being cultivated, harvested and exported by the worlds poorer nations. And although there has been recent attention to Fair Trade coffeewhich brings more economic benefits to growersFair Trade makes up just 5 percent of the U.S. coffee market.

New research led by Kelly Austin, associate professor of sociology at Lehigh, explores unequal exchange in the coffee industry. She cites a range of negative consequences that coffee cultivation contributes to, including: malaria vulnerability, decreased participation in schooling, gender inequalities, and environmental degradation in Bududa, Uganda.

In Bududa, UgandaAfricas second largest coffee exporter following Ethiopiathe harvest typically runs from July through October. The season can extend beyond this, depending on the amount of rainfall, temperatures and the ripeness of the coffee cherries.

Located in the eastern region of Uganda, Bududa lies at the foot of the slopes of the Mount Elgon volcano, which provides a unique set of natural resources that make it an optimal place for cultivation of Arabica beans. The Arabica beans are considered higher quality in comparison to Robusta coffee, which is cultivated in the warmer, lower-lying regions in central Uganda.

For her research, Austin interviewed Bududa residents between the ages of 30 and 76, all of whom had been been involved in coffee cultivation for several years, with many of them learning to cultivate from childhood or adolescence. She drew on over 11 months of participant observation while living with a local family who grows coffee to supplement their income.

Conducting interviews with coffee growers in the Bududa District is vital in unearthing the processes, trends and consequences of coffee cultivation in the region, Austin wrote.

...

02:51

Unlabelled Genetically Modified Salmon Discovered Sold Into Quebec, Canada Natural Blaze

Montreal: Investigations by the Canadian Biotechnology Action Network, Ecology Action Centre and the Quebec network Vigilance OGM reveal that the worlds first sale of genetically modified (GM or genetically engineered) salmon could have gone exclusively into the Quebec market.

Quebeckers could have unknowingly eaten the GM salmon anywhere in restaurants, or through food service at hospitals or universities, or in processed food products sold in stores, said Thibault Rehn of Vigilance OGM.

Government statistics on Canadian imports show a shipment of salmon from Panama to Quebec that closely matches the amount of GM Atlantic salmon that the company AquaBounty says it sold in Canada, in the timeframe the company says it made the sale.(1) The company is currently only producing GM salmon in Panama. Canada imported more salmon from Panama this year than in previous years.

In the companys August 4th financial report, GM fish company AquaBounty revealed it had sold approximately 4.5 metric tonnes of GM salmon into Canada sometime between April and June 30 2017. This was the worlds first sale of a genetically modified food animal and Canada is currently the only market where this GM product can be sold.

AquaBounty did not disclose where it sold the GM salmon or into what type of food market. However, most major retailers say that they are not selling the GM fish as fr...

02:00

The Outside And The Inside Geoengineering Watch

the-outside-and-the-insideSource: Born Outside The Box by Zen Gardner July 17, 2017 Were all outsiders and insiders in various respects. Social circles, generally speaking, are just one aspect but they often affect us to drastic degrees. Acceptance by others and needing a sense of belonging are strong driving forces in most peoples lives. Sometimes these coincide

01:55

Swedish prosecutor wont pursue criminal case against Macchiarini Retraction Watch

A Swedish prosecutor has announced she wont continue investigating a former star surgeon who has since fallen from grace. Paolo Macchiarini made a name for himself by transplanting synthetic tracheas. After multiple patients died, however, allegations against the researcher have continued to swirl. He was dismissed from the Karolinska Institutet last year, after it reopened []

The post Swedish prosecutor wont pursue criminal case against Macchiarini appeared first on Retraction Watch.

Thursday, 12 October

23:13

Second Detroit Mom Refuses Vaccine Orders In Court Vaxxter

It has been less than a few days since Rebecca Bredow walked out of a Michigan jail, time served for refusing to vaccinate her son, and into a court hearing whereas she was informed that...

The post Second Detroit Mom Refuses Vaccine Orders In Court appeared first on Vaxxter.

22:26

Excessive Maternal Fluoride Levels May Lower Child IQ Fluoride Action Network

Note from FAN: The title is misleading. This study had fluoride exposures almost the same as what is found in fluoridating countries like the USA. See more

High prenatal fluoride exposure during pregnancy is associated with poorer scores on tests of cognitive function in offspring, according to a new study.

Researchers at the University of Toronto (Canada), Instituto Nacional de Salud Pblica (Cuernavaca, Mexico), and other institutions conducted a study of 299 motherchild pairs to estimate the association of prenatal exposure to fluoride with offspring neurocognitive development. The researchers used an ion-selective electrode technique to measure fluoride in archived urine samples taken from mothers during pregnancy and from their children when 612 years old, adjusted for urinary creatinine and specific gravity.

Child intelligence was measured by the general cognitive index (GCI) of the McCarthy Scales of Childrens Abilities at age four, and full-scale intelligence quotient (IQ) from the Wechsler Abbreviated Scale of Intelligence (WASI) was measured at ages 612. Mean values for urinary fluoride in all of the mothers and children were 0.90?mg/L and 0.82?mg/L, respectively. Analysis revealed that an increase in maternal urine fluoride of 0.5mg/L predicted a reduction of 3.15 in the childrens GCI and 2.50 in their IQ scores, respectively. The study was published in the September 2017 issue of Environmental Health Perspectives.

Our study shows that the growing fetal nervous system may be adversely affected by higher levels of fluoride exposure. It also suggests that the prenatal nervous system may be more sensitive to fluoride compared to that of school-aged children, concluded study co-author Howard Hu, MD, of the University of Toronto, and colleagues. Our findings, combined with evidence from existing animal and human studies, reinforce the need for additional research on potential adverse effects of fluoride, particularly in pregnant women and children.

Fluoride is the simplest anion of fluorine. Community water, salt, milk, and dental products have been fluoridated for more than 60 years to prevent dental caries, while fluoride supplementation has been recommended to prevent bone fractures. In addition, people may be exposed to fluoride through the consumption of naturally contaminated drinking water, dietary sources, dental products, and other sources. The maximum safe daily consumption of fluoride is 10 mg/day for an adult (U.S.) or 7 mg/day (European Union).

Related Links:
University of Toronto
Instituto Nacional de Salud Pblica

*Original article online at ...

11:06

Geoengineering Is Fueling Firestorm Catastrophes Geoengineering Watch

GeoengineeringWatch.org 33421Dane Wigington GeoengineeringWatch.org All official sources are blaming the increasingly extreme and deadly wildfire behavior on global warming alone, but is that the full truth? What are official sources not telling us about the increasingly destructive wildfires? Illegal global climate engineering / solar radiation management operations are a primary causal factor that is fueling catastrophic wildfires

09:33

Woman With Breast Cancer Slams Pink Marketing As Hoax Vaxxter

Facebook user Tracie Marie posted a photo of herself fighting breast cancer, along with a strong condemnation of the breast cancer pink awareness campaign that inundates our stores, products, and even the NFL. Her very...

The post Woman With Breast Cancer Slams Pink Marketing As Hoax appeared first on Vaxxter.

07:51

Jailed Vaccine Mom Loses Primary Custody Of Son Vaxxter

The mother who opted to go to jail rather than vaccinate her son has now learned of a worse fate than jail: Shes lost primary custody of her child. According to wxyz.com, Rebecca Bredows son was...

The post Jailed Vaccine Mom Loses Primary Custody Of Son appeared first on Vaxxter.

05:29

Baby Foreskin Reportedly Sold To Vaccine Makers Vaxxter

Warning: Some people may find the information in this article disturbing and the images graphic. Every year, some infants are circumcised. During this surgical procedure, part of the childs protective penile tissue is removed. This...

The post Baby Foreskin Reportedly Sold To Vaccine Makers appeared first on Vaxxter.

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