IndyWatch Health Watch Feed Archiver

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

IndyWatch Health Watch Feed was generated at Community Resources IndyWatch.

Tuesday, 17 July

00:25

Just 1 teaspoon of this binds carcinogens even better than a pound of spinach Health Nut News

Photosynthesis is the process in which plants absorb light from the sun along with water and carbon dioxide and transform it into the food they need for growth. Oxygen, the nutrient that virtually all eukaryotic cells require to generate energy in their mitochondria, is a byproduct of photosynthesis. At the heart of photosynthesis is []

The post Just 1 teaspoon of this binds carcinogens even better than a pound of spinach appeared first on Health Nut News.

00:21

All these findings show that even exposure to low glyphosate levels can have serious adverse effects GreenMedInfo

PMID:  Arh Hig Rada Toksikol. 2018 Jun 1 ;69(2):154-168. PMID: 29990293 Abstract Title:  Oxidative stress, cholinesterase activity, and DNA damage in the liver, whole blood, and plasma of Wistar rats following a 28-day exposure to glyphosate. Abstract:  In this 28 day-study, we evaluated the effects of herbicide glyphosate administered by gavage to Wistar rats at daily doses equivalent to 0.1 of the acceptable operator exposure level (AOEL), 0.5 of the consumer acceptable daily intake (ADI), 1.75 (corresponding to the chronic population-adjusted dose, cPAD), and 10 mg kg-1 body weight (bw) (corresponding to 100 times the AOEL). At the end of each treatment, the body and liver weights were measured and compared with their baseline values. DNA damage in leukocytes and liver tissue was estimated with the alkaline comet assay. Oxidative stress was evaluated using a battery of endpoints to establish lipid peroxidation via thiobarbituric reactive substances (TBARS) level, level of reactive oxygen species (ROS), glutathione (GSH) level, and the activity of glutathione peroxidase (GSH-Px). Total cholinesterase activity and the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were also measured. The exposed animals gained less weight than control. Treatment resulted in significantly higher primary DNA damage in the liver cells and leukocytes. Glyphosate exposure significantly lowered TBARS in the liver of the AOEL, ADI, and cPAD groups, and in plasma in the AOEL and cPAD group. AChE was inhibited with all treatments, but the AOEL and ADI groups significantly differed from control. Total ChE and plasma/liver ROS/GSH levels did not significantly differ from control, except for the 35 % decrease in ChE in the AOEL and ADI groups and a significant drop in liver GSH in the cPAD and 100xAOEL groups. AOEL and ADI blood GSH-Px activity dropped significantly, but in the liver it significantly increased in the ADI, cPAD, and 100xAOEL groups vs. control. All these findings show that even exposure to low glyphosate levels can have serious adverse effects and points to a need to change the approach to risk assessment of low-level chronic/sub-chronic glyphosate exposure, where oxidative stress is not necessarily related to the genetic damage and AChE inhibition.

read more

00:16

High concentrations of glyphosate are deleterious to immature bees. GreenMedInfo

PMID:  J Agric Food Chem. 2018 Jul 11. Epub 2018 Jul 11. PMID: 29992812 Abstract Title:  The Herbicide Glyphosate Negatively Affects Midgut Bacterial Communities and Survival of Honey Bee during Larvae Reared in Vitro. Abstract:  Effects of glyphosate on survival, developmental rate, larval weight, and midgut bacterial diversity of Apis mellifera were tested in the laboratory. Larvae were reared in vitro and fed diet containing glyphosate 0.8, 4, and 20 mg/L. The dependent variables were compared with negative control and positive control (dimethoate 45 mg/L). Brood survival decreased in 4 or 20 mg/L glyphosate treatments but not in 0.8 mg/L, and larval weight decreased in 0.8 or 4 mg/L glyphosate treatments. Exposure to three concentrations did not affect the developmental rate. Furthermore, the intestinal bacterial communities were determined using high-throughput sequencing targeting the V3-V4 regions of the 16S rDNA. All core honey bee intestinal bacterial phyla such as Proteobacteria (30.86%), Firmicutes (13.82%), and Actinobacteria (11.88%) were detected, and significant changes were found in the species diversity and richness in 20 mg/L glyphosate group. Our results suggest that high concentrations of glyphosate are deleterious to immature bees.

read more

00:08

Red light-emitting diode irradiation regulates oxidative stress and inflammation. GreenMedInfo

PMID:  J Photochem Photobiol B. 2018 May 26 ;186:31-40. Epub 2018 May 26. PMID: 30005204 Abstract Title:  Red light-emitting diode irradiation regulates oxidative stress and inflammation through SPHK1/NF-B activation in human keratinocytes. Abstract:  Oxidative stress, in which the amount of oxidants exceeds the capacity of antioxidant defense system, is a well-accepted pathogenesis of several human diseases. Light-emitting diode irradiation (LEDI) is an efficient strategy to counteract this condition. The biological effect of phototherapy, using visible light, has attracted recent attention especially in dermatological practice. However, little is known about the molecular mechanism of the anti-oxidant and anti-inflammatory effects of red light irradiation. We evaluated these effects of LEDI in HaCaT human keratinocyte cells under phorbol-12-myristate-13-acetate (PMA) induced reactive oxygen species (ROS). Microarray analysis revealed changes in 309 genes after LEDI. LEDI at 625nm produced ROS scavenging and anti-inflammatory effects. One of the most important genes identified by microarray analysis was sphingosine kinase-1 (SPHK1), which is a key molecule in sphingolipid metabolism. SPHK1 knock-down drastically reduced ROS scavenging efficiency as well as expression levels of inflammation-related proteins in PMA-treated HaCaT cells. These results not only indicate the potential for the clinical application of 625-nm LEDI in treating skin disorders via ROS and/or inflammation, but also suggest SPHK1 as a potential therapeutic target in phototherapy.

read more

00:03

12-yr-old Mia left paralyzed from the HPV vaccine Health Nut News

We will continue to speak out against this incredibly dangerous vaccine and share stories like Mias until HPV has been taken off the market. Giving this vaccine to your children is like playing Russian roulette. In fact, weve written many stories over the last 5 years about the dangers of the HPV vaccine: HPV vaccines likely contribution []

The post 12-yr-old Mia left paralyzed from the HPV vaccine appeared first on Health Nut News.

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Monday, 16 July

23:57

Protective effect of morin on myocardial ischemiareperfusion injury in rats. GreenMedInfo

PMID:  Int J Mol Med. 2018 Jun 26. Epub 2018 Jun 26. PMID: 29956744 Abstract Title:  Protective effect of morin on myocardial ischemiareperfusion injury in rats. Abstract:  Morin, a natural flavonol, exhibits antioxidative, antiinflammatory and antiapoptotic effects in various pathological and physiological processes. However, whether morin exerts a protective effect on myocardial ischemiareperfusion injury (MIRI) is unknown. The present study aimed to determine the effect of morin on MIRI in cultured cardiomyocytes and isolated rat hearts, and to additionally explore the underlying mechanism. The effect of morin on the viability, lactate dehydrogenase (LDH) activity and apoptosis of H9c2 cardiomyocytes subjected to hypoxia/reoxygenation, and cardiac function and infarct size of rat hearts following ischemia/reperfusion in an animal model were measured. Furthermore, the mitochondrial permeability transition pore (MPTP) opening, mitochondrial membrane potential (m), and the change in the expression levels of Bcell lymphoma 2 (Bcl2)associated X protein (Bax), Bcl2 and mitochondrial apoptosisassociated proteins following MPTP opening were also detected. The results indicated that morin treatment significantly increased cell viability, decreased LDH activity and cell apoptosis, improved the recovery of cardiac function and decreased the myocardial infarct size. Furthermore, morin treatment markedly inhibited MPTP opening, prevented the decrease of m, and decreased the expression of cytochrome c, apoptotic protease activating factor1, caspase9, caspase3 and the Bax/Bcl2 ratio. However, these beneficial effects were reversed by treatment with atractyloside, an MPTP opener. The present study demonstrated that morin may prevent MIRI by inhibiting MPTP opening and revealed the possible mechanism of the cardioprotection of morin and its acting target. It also provided an important theoretical basis for the research on drug interventions for MIRI in clinical applications.

read more

23:50

Morin attenuates doxorubicin-induced heart and brain damage. GreenMedInfo

PMID:  Biomed Pharmacother. 2018 Jul 2 ;106:443-453. Epub 2018 Jul 2. PMID: 29990832 Abstract Title:  Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Abstract:  Doxorubicin (DOX) is an effective antineoplastic agent of the anthracycline group. However, as with most anticancer drugs, they cause some toxic effects, including major cardiotoxicity and cognitive impairment. In this study, protective effects of morin against DOX-induced cardiotoxicity and neurotoxicity in rats were investigated. Morin was orally administered to rats at a dose of 50 and 100mg/kg body weight for 10 days. DOX was administered 40mg/kg body weight by single dose intraperitoneal injection on the 8th day of the study. Both the levels of glutathione (GSH) and malondialdehyde (MDA) were assessed and enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were assessed to determine the protective effect of morin against oxidative stress. To determine the anti-inflammatory effect, the levels of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), nuclear factor kappa B (NF-B) were assessed in the heart and brain tissues. Lactate dehydrogenase (LDH) and creatine kinase isoenzyme-MB (CKMB) activities, which are cardiac function markers, and cardiac troponin-I (cTn-I) levels were also determined. Anti-apoptotic effect was determined by anti-apoptotic protein B-cell lymphoma-2 (Bcl-2) and pro-apoptotic protein cysteine aspartate specific protease-3 (caspase-3) changes. The regulatory role of morin in signal transduction in the brain tissue was assigned with the determination of amount of acetylcholinesterase (AChE), and its healing effect on the central nervous system was determined with imuinohistochemicaldetection of glial fibrillar acidic protein (GFAP) level. Histopathological evaluation of heart and brain tissues was performed in all groups.

read more

23:45

A review of the role of morin in neurodegenerative diseases. GreenMedInfo

PMID:  Curr Top Med Chem. 2018 Jul 11. Epub 2018 Jul 11. PMID: 29992884 Abstract Title:  Role of Morin in Neurodegenerative Diseases: A review. Abstract:  Neurodegenerative diseases are likely to be emerged as the second cause of mortality in the world in coming years. NDDs causes tremendous financial burden on the healthcare system along with profound effect on families and patient. Disease-modifying treatment strategies with proven efficacy for these disorders are still lacking. Documentation proved that oxidative stress plays leading role in the pathophysiology of many neurodegenerative disorders. Molecules with good antioxidant profile could be explored for the doctoring of these conditions. Neuroprotective effects of bioflavonoid morin have been well recognized in literature. Morin being super antioxidant compound helped in preventing and curing these disorders by suppression of ROS and by inhibition of multiple targets. In this review we tried to explain various neuropathological conditions with their target sites and neurobiological mechanisms of morin.

read more

23:37

Robert F. Kennedy, Jr. and an Amazing Vaccine Legal Victory BolenReport

Del Bigtrees Master Class on Vaccines and Autism Part 1 By Kent Heckenlively, JD On Thursday, July 12, 2018, Del Bigtrees show, High-Wire, gave a master class on vaccines and autism, featuring some of the most exciting news we have heard in YEARS.  The link to the show is below. I have broken the Continue reading Robert F. Kennedy, Jr. and an Amazing Vaccine Legal Victory

The post Robert F. Kennedy, Jr. and an Amazing Vaccine Legal Victory appeared first on BolenReport.

23:33

Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders. GreenMedInfo

PMID:  J Ethnopharmacol. 2018 Jun 2 ;224:242-249. Epub 2018 Jun 2. PMID: 29870788 Abstract Title:  Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Ficus carica fruit, a source of bioactive functional ingredients, have been traditionally long time used for its medicinal benefits as they improve the digestive system, treating constipation and used as a natural laxative.AIM OF THE STUDY: The recent study was investigated the ameliorative effect of Ficus carica L. aqueous extract (FCAE) on delayed gastric emptying and ulcerative colitis-improved motility disturbances in dextran sulfate sodium (DSS)-induced acute colitis in rats.MATERIALS AND METHODS: Wistar rats were assigned randomly and received 5% DSS for seven days. Ulcerative colitis diagnosis was confirmed by clinical signs, visible fecal blood and histopatological evaluation. The estimation of the action of colitis on TGI and constipation as well as the protective effect of extract, the intestinal biochemical and physiological parameters were measured using the charcoal meal test, loperamide (Lop)-induced constipation as well as spectrophotometric assays. FCAE (150 and 300mgkg) was administered orally once per day for seven days 1h after the loperamide treatment. Phenol-red colorimetric method was used to explore the action of FCAE on gastric emptying process.RESULTS: Ulcerative colitis caused a significantly gastrointestinal motility inhibition in normal rats and notably aggravated the constipation in LOP group. Oppositely, FCAE oral intake significantly increased levels of the gastrointestinal transit ratio and gastric emptying by accelerating of their times. Moreover, constipation severity induced by colitis was remarkably reduced in the FCAE treatment group, as demonstrated by a marked management of fecal parameters, water content, oxidative stress indicators, lipid metabolism, and intracellular mediators. Phytochemical analysis of FCAE revealed the presence of carbohydrates, polysaccharides, phenolic acids as gallic acid, chlorogenic acid, syringic acid and ellagic acid, and flavonoids (e.g. rutin, catechin, epicatechin and apeginine).CONCLUSIONS: The obtained results indicated that FCAE exhibits a natural laxative effect without provoking diarrhea and ameliorates functional gastrointestinal (GI) and motility disorders thus justifying its traditional usage.

read more

23:11

12 Mental Health Design Principles to Replace This Thing Mad In America

the author Corinna West with Gayle Bluebird at Alternatives 2012 in Orlando.

23:07

The North Dakota Department of Human Services Welcomes Feedback as it Renews the Autism Spectrum Disorder Waiver AGE OF AUTISM

Note: America is a big country with 50 states. Every state has different services for autism. Some are pretty good, some are abjectly terrible. North Dakota is reaching out for feedback on the ASD waiver, which stops at age 12....

22:52

Monsantos Roundup on trial: Day 2 in court Health Nut News

(Editors Note: Thank you for all the hard work that Organic Consumers Association does. Please read on.) Thanks to Robert F. Kennedy, Jr. for providing a recap of the second day in court in the Dewayne Johnson vs. Monsanto Co. trial. Proceedings began in San Francisco Superior Court on Monday, July 9. The plaintiff, Dewayne Johnson, a 46-year-old []

The post Monsantos Roundup on trial: Day 2 in court appeared first on Health Nut News.

22:49

Urgent: If your doctor suggests this, say no and hightail it out of there Health Nut News

According to the U.S. Centers for Disease Control and Prevention (CDC), 115 Americans, on average, die of an opioid overdose every day. The increasing use of opioid painkillers and the rampant rates of addiction to them have become a social issue that transcends all geographic and socioeconomic boundaries. Drug overdoses now affect people of every []

The post Urgent: If your doctor suggests this, say no and hightail it out of there appeared first on Health Nut News.

22:00

Gluten-free turkeys? Paper on dangers of wheat-based diet in birds retracted Retraction Watch

The journal Scientifica has retracted a 2016 paper on gut disease in turkeys for a rafter of sins including plagiarism and authors plucked out of thin air. The article, Role of wheat based diet on the pathology of necrotic enteritis in turkeys, was purportedly written by a team from Pakistan and France. But it turns Continue reading Gluten-free turkeys? Paper on dangers of wheat-based diet in birds retracted

20:45

22 Women Share $4 Billion Johnson & Johnson Penalty. Thousands of Autism Mothers Told to Take a Powder. AGE OF AUTISM

And the product is still on the shelves. Did you ever get a true informed consent WARNING that the vaccines you were giving your children had ANY threat of danger? I did not. I have my signed in hospital birth...

20:02

A Simple Emergency Room Intervention Can Cut Suicide Risk Mad In America

From NPR: Many people who attempt suicide end up in an emergency room for immediate treatment. But few of those suicide survivors get the follow-up care they need at a time when they are especially likely to attempt suicide again.

Now, a study shows that a simple intervention conducted by staff in emergency departments can reduce the risk of future attempts. The intervention involves creating a safety plan for each patient and following up with phone calls after discharge.

It reduced the odds of suicidal behavior by half, says Barbara Stanley, a psychologist at Columbia University and the lead author of the study. Thats a phenomenal difference.'

Article 

20:01

Early Life Experience: Its In Your DNA Mad In America

From Scientific American: We know that the activity and organization of the brain changes in response to experience. Memories and learning are reflected in the number and strength of connections between nerve cells. We also know that the brain is genetically mosaic, but a new study makes a remarkable connection between experience and the genetic diversity of the brain. It suggests that experience can change the DNA sequence of the genome contained in brain cells. This is a fundamentally new and unexplored way in which experience can alter the brain. It is of great scientific interest because it reveals the brain to be pliable, to its genetic core, in response to the world.

Article 

20:01

Revisiting the Rationale and Evidence for Peer Support Mad In America

From Psychiatric Times: A recent issue featured an opinion piece by D.J. Jaffe who argued that there is little empirical support for the effectiveness of paid peer-support staffpersons in recovery from mental illness who are trained to provide support to otherson the outcomes of homelessness, arrest, incarceration, violence, and needless hospitalization. In this article, we rebut Mr Jaffes argument by revisiting the rationale and evidence base for peer support.

While we agree that the government needs to fund more research on this important topic, we argue that stating that peer support lacks evidence is simply not accurate. In fact, as we will explain below, over 30 studies have found positive effects in numerous outcome domains. But first, it is important to understand the nature and intended impact of this form of service delivery.

Article 

 

20:00

Former Service User Studies the Inpatient Experience Mad In America

A recent paper, written by Diana Rose from Kings College London, details the process of developing a patient-devised, patient-reported outcome measure. While discussing the complications that surface when engaging in participatory research, Rosea researcher and former service-userreflects on the process of working with other service-users to understand the inpatient experience.

The aim of this process was to develop a measure grounded entirely in the experiences of mental health service users in contrast to how such measures are usually derived, Rose writes.

Rose calls attention to the importance of smaller scale, qualitative studies that highlight individuals lived experiences in the mental health system. She argues that these studies are necessary as a complement to larger epidemiological studies and the growing fascination with big data research.

In this new paper, Rose focuses on what is known in the field as participatory research, a method that hinges on carefully considering the impact of power relations between the researcher and the researched, and on working to reduce power discrepancies through collaboration. Rose explains:

One of the founding principles of participatory research, and the one of interest here, is that it should level the power relations between researchers and the community in the research itself...

15:33

Long time Infowars top engineer killed in accident, rest in peace Health Nut News

We just wanted to say rest in peace to Joe Jennings. No matter what you think of Infowars, this is a terrible loss. This Dad and husband leaves a wife and 4 children behind. Heres a GOFUNDME link for his wife and children.  

The post Long time Infowars top engineer killed in accident, rest in peace appeared first on Health Nut News.

15:00

The Surprising Connection Between Bone Health and Heart Health Articles

By Dr. Mercola

The suspected link between bone health and heart health is nothing new. In their attempts to uncover links between cardiovascular disease and osteoporosis, for example, researchers have looked at several areas, such as biochemical processes, genetic factors and shared risk factors. On a parallel path, other scientists are investigating how certain vitamins and minerals interact and affect the human body, including their impact on your heart.

Again and again, the synergistic relationship among vitamin D, vitamin K2, calcium and magnesium, as well as the vital role of probiotics, continues to be highlighted. Given its universal importance, lets take a closer look at the surprising connection between the health of your bones and the health of your heart.

A Healthy Gut = Strong Bones: Probiotics Shown to Influence Your Bone Mineral Density

A 2018 study published in the Journal of Internal Medicine1 put probiotics specifically Lactobacillus reuteriATCC PTA 6475 (L. reuteri 6475) to the test to evaluate its effects on human bone mineral density. Previously, scientists noted gut health positively influenced bone metabolism in lab mice.2 Seventy women aged 75 to 80 years old with low bone mineral density completed the study.

The women received an oral daily dose of 1010 colonyforming units of L. reuteri 6475 or a placebo. Those receiving the probiotic were found to suffer less bone loss (based on tibia total volumetric bone mineral density) than the placebo group. The study authors stated, [S]upplementation with L. reuteri 6475 should be further explored as a novel approach to prevent ageassociated bone loss and osteoporosis.3

A Chinese study published in 20174 highlighted the important role healthy gut bacteria plays for women contending with postmenopausal osteoporosis (PMO). The researchers suggested bone loss with respect to PMO is closely associated with the health of your immune system and your gut. They noted:5

Probiotics prevent bone resorption by restoring intestinal microbial diversity, enhancing the intestinal epithelial barrier and normalizing aberrant host immune responses, as well as facilitating intestinal calcium absorption and the potential production of estrogen-like metabolites Hence, the intestinal microbiota serves as a key factor...

What Are the Signs of Vitamin B Complex Deficiency? Articles

By Dr. Mercola

Traditional media often run stories about how supplements may cause problems. One of the problems with studies highlighting supplements is they typically use synthetic vitamins, and not whole food supplements. Your body was not made to process unnatural agents, often posing as equivalents to the real thing. The reality is they are frequently not the same and do not provide you with the same health benefits.

Vitamin deficiencies may lead to illness and disease, and contribute to chronic issues such as high blood pressure, dementia and cancer. One nutritional deficiency having the potential to wreak havoc on your health, your cognition and even your respiratory system is a deficiency in vitamin B complex. B vitamins also help your body to detoxify from chronic exposure to pollutants and chemicals.

Elderly Have Higher Rates of Deficiency

A large population study conducted in Ireland1 discovered a larger than expected number of adults over age 50 with vitamin B12 and folate deficiencies. Researchers from Trinity College Dublin2 analyzed information from over 5,000 adults to establish a general level of vitamin B12 and folate in a mature population.

Public health policies in many countries have suggested supplementing processed foods with folic acid and vitamin B12 may ensure the population at large has access to these nutrients. However, the present findings3 suggest official health policies may not be sufficient. The researchers noted both folate and vitamin B12 are crucial to brain health, red blood cell production and synthesis and repair of DNA and nerve functions.4

The data revealed as many as 1 in 8 older adults has low levels of vitamin B12 or a B12 deficiency, and 1 in 7 has low or deficient folate levels. As the age of the participants increased, the prevalence of inadequate folate levels seemed to increase. Percentages rose from 14 percent in people up to 60 years, rising to 23 percent in participants older than 80.5

Past studies have linked poor long-term health, especially in older adults, to low nutritional levels of folate and vitamin B12. The high rates of deficiency seen in older populations are cause for concern. Dr. Rose Anne Kenny, principal investigator in the study,6 believes since these deficiencies may be treated with food fortification, significant policy and practice implication...

Why You Should Eat More Chlorophyll-Rich Foods Articles

By Dr. Mercola

Photosynthesis is the process in which plants absorb light from the sun along with water and carbon dioxide and transform it into the food they need for growth.1 Oxygen, the nutrient that virtually all eukaryotic cells require to generate energy in their mitochondria, is a byproduct of photosynthesis.

At the heart of photosynthesis is chlorophyll,2 a pigment that absorbs blue and some red portions of the electromagnetic spectrum and gives the plant its green color. The deeper, darker the green, the more chlorophyll the plant contains.

Chlorophyll is also found in algae and cyanobacteria, both of which also use photosynthesis to create their own nourishment. You probably know that vegetables are an important part of a healthy diet, and while plant foods contain a wide variety of plant chemicals that promote health, chlorophyll is an important part of the health equation.

Biological Activity of Chlorophyll

Chlorophyll has a number of important biological activities, several of which offer protection against cancer. This includes:3,4

  • Binding to carcinogenic chemicals, allowing your body to safely eliminate them. This includes polycyclic aromatic hydrocarbons from tobacco smoke, heterocyclic amines from cooked meat and aflatoxin-B1, a mycotoxin found in moldy peanuts and other grains and legumes
  • Antioxidant effects, decreasing cellular damage caused by carcinogenic chemicals and radiation
  • Inhibiting cytochrome P450 enzymes, which are required for the activation of procarcinogens. This is yet another way in which chlorophyll helps decrease your risk of chemically-induced cancers

Chlorophyllin, a semi-synthetic sodium copper salt derived from chlorophyll (and the type typically found in chlorophyll supplements), has similar benefits. In addition to inhibiting cancer, it has also been shown to have deodorizing and healing effects. Its been used topically for foul-smelling and/or slow-healing wounds such as vascular ulcers and pressure ulcers, and taken orally, chlorophyllin supplements have been shown to reduce urine and fecal odor in patients struggling with incontinence.

Topical application may also reduce signs of photoaging,5 in part by inhibiting the breakdown of hyaluronic acid in your...

Weekly Health Quiz: Ginger, Fitness and Energy Articles

1 Which of the following has been shown to ease menstrual pain as effectively as ibuprofen?

  • Apple cider vinegar
  • Garlic
  • Ginger

    One of the most well-recognized health benefits of ginger is the easing of pain; research shows it can ease menstrual pain as effectively as ibuprofen. Learn more.

  • Bergamot oil

2 Which of the following statements is false?

  • Recent research found people, who had gotten seasonal flu shots and contracted influenza shed infectious viruses through exhaled breath; those vaccinated two seasons in a row had a greater viral load of influenza A virus
  • Research shows flu vaccinations may promote lung inflammation
  • Studies show annual vaccination leads to reduced protection against influenza
  • Recent research found people who had gotten seasonal flu shots and contracted influenza did not shed infectious influenza viruses, while unvaccinated people did

    Recent research found infectious influenza viruses in the exhaled breath of people who had gotten seasonal flu shots and contracted influenza, suggesting vaccination promotes greater shedding of influenza A viruses and may promote lung inflammation. Those vaccinated two seasons in a row shed a greater viral load. Other studies show annual vaccination lowers protection against influenza infection. Learn more.

3 Which of the following was the first national grocery chain to set a deadline for full GMO transparency?

  • Whole Foods Market

    In 2013, Whole Foods became the first national grocery chain to set a deadline for the implementation of GMO labeling. The labeling policy was scheduled to take effect September 1, 2018, but May 18, the company announced the requirement is being pushed back, although no new deadline has been set....

13:20

Breaking: New CBS show Whistleblower does damning piece on Kool Smiles dental chain, kids dying, etc. Health Nut News

As many of you know, Ive been writing about Kool Smiles dentistry, who some say specialize in low-income children, for years. In fact, Im being sued by a dentist (whose name I wont mention right now) I wrote about a few years ago, after a child who was having work done at his clinic died. []

The post Breaking: New CBS show Whistleblower does damning piece on Kool Smiles dental chain, kids dying, etc. appeared first on Health Nut News.

10:15

One Way To Increase Your Beneficial Bacteria Without Any Food Natural Blaze

By Karen Foster

It turns out that exercise can do more than slim down your waistline and boost heart health. It might also make whats inside your gut healthier, according to a new study by San Francisco State University.

In this first-of-its-kind study, just published in the International Journal of Sport Nutrition and Exercise Metabolism, recent SF State graduate student Ryan Durk and Assistant Professor of Kinesiology Jimmy Bagley partnered with the SF State Health Equity Research (HER) Lab to test the relationship between gut health and cardiovascular fitness.

Durk (who received his masters degree in kinesiology last December) recruited 20 men and 17 women, mostly from the SF State campus, and tested their cardiovascular fitness on a treadmill. He also assessed their body composition in the labs BOD POD, an air displacement ch...

09:22

Is Australias Vaccine Policy A Nightmare Or A Pogrom? Natural Blaze

By Catherine J. Frompovich

The term pogrom has multiple meanings, ascribed most often to the deliberate persecution of an ethnic or religious group either approved or condoned by the local authorities. (Source)

The people of Australia are being denied by law one of the most important inalienable rights of human existence, the ability to choose how to take care of ones children and their bodies, plus the exercise of their basic human right to freedom of choice in healthcare invoking the heretofore scientific-acknowledgement to cope with possible risks where scientific understanding is yet incomplete, such as the risks of nano technology, genetically modified organisms and systemic insecticides [1], aka the Precautionary Principle, to avoid damage from neurotoxic vaccines. Nano technology and genetically modified organisms are IN vaccines! I hereby challenge Big Pharma and vaccine makers to prove me wrong!

The Australian government seemingly has gone off the rails relative to the punitive measures it has instituted against citizens who elect not to have their children or themsel...

08:42

Kidney Stones: Early Signs and Symptoms You Shouldnt Ignore Healthy and Natural World

Kidney stones can cause excruciating pain that can spread from your middle back through your abdomen to your pelvis. The agony from kidney stones can be worse when you try to urinate and can feel like a strong burning sensation. In some cases, kidney stones can cause a fever and you may notice the presence of blood in your urine (hematuria).

In many cases, kidney stones actually pass without causing any painful symptoms. Drinking plenty of water or drinking acidic drinks like apple cider vinegar can help to flush out even painful kidney stones. If you have extreme kidney stone pain, then you should see a doctor who will recommend the best way to get rid of the renal stones.

In this article, I will look at the many signs and symptoms of kidney stones. Very often, treating the first signs of kidney stones can help to prevent many of the painful symptoms that are associated with them. You will also learn what scientific evidence says about treating kidney stones naturally.

What Are Kidney Stones?

Kidney stones are small hard mineral and salt deposits that can form in the kidneys. Doctors from PubMed Health say that urine contains various minerals that can crystallize if the urine is too concentrated. Over time, these crystallized compositions form into stone-like structures of varying shapes and size.1

Dr. Chirag Dave, an urologist from William Beaumont Health System, says that kidney stone disease is called nephrolithiasis. The medical name for kidney stones is renal calculi.2

Dr. Dave says that there are 4 main types of kidney stones, depending on the mineral composition:

  • Calcium stones. Most kidney stones are calcium stones that are made up of calcium oxalate or phosphate. Low fluid intake and consuming foods high in calcium oxalate can cause these types of kidney stones to form.
  • Struvite stones. These types of kidney stones account for about 15% of all cases of renal pain and are made up of magnesium and phosphate. Struvite stones are often connected with recurring urinary tract infections.
  • Uric acid stones. Uric acid stones form when there is too much uric acid in the urine and are associated with consuming foods that have high purine levels.
  • Cystine stones. Less common than the other types of kidney stones, cystine stones are connected with a metabolic defect.

What Do Kidney Stones Look Like?

Mineral deposits that form in the kidney look like small stones with ragged edges. In some cases, the stones may look as small as a grain of sand and will pass through the urinary system without any n...

04:57

"Ginger's List" of Ignored Research Showing How Vaccines Cause Autism Tops 150 Papers AGE OF AUTISM

by Ginger Taylor MS, about Ginger Taylor MS The Age of Autism, represented here by Ginger Taylor MS, at the behest of Ginger Taylor MS, is proud to honor Ginger Taylor MS on her stunning accomplishment of the discovery of...

04:53

Coconut oil attenuates the effects of amyloid- on cortical neurons in vitro. GreenMedInfo

PMID:  J Alzheimers Dis. 2014 ;39(2):233-7. PMID: 24150106 Abstract Title:  Coconut oil attenuates the effects of amyloid- on cortical neurons in vitro. Abstract:  Dietary supplementation has been studied as an approach to ameliorating deficits associated with aging and neurodegeneration. We undertook this pilot study to investigate the effects of coconut oil supplementation directly on cortical neurons treated with amyloid- (A) peptide in vitro. Our results indicate that neuron survival in cultures co-treated with coconut oil and A is rescued compared to cultures exposed only to A. Coconut oil co-treatment also attenuates A-induced mitochondrial alterations. The results of this pilot study provide a basis for further investigation of the effects of coconut oil, or its constituents, on neuronal survival focusing on mechanisms that may be involved.

read more

04:44

Chrysin may act as a promising therapeutic candidate for targeting bladder cancer. GreenMedInfo

PMID:  Oncol Lett. 2018 Jun ;15(6):9117-9125. Epub 2018 Apr 18. PMID: 29805643 Abstract Title:  Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells. Abstract:  Chrysin is a natural flavone that has various biological activities, including antitumor effects. However, the effect of chrysin on bladder cancer cells remains elusive. The present study investigated the effects of chrysin on bladder cancer cells and its underlying mechanisms. The results demonstrated that chrysin induced apoptosis via the intrinsic pathway, as evidenced by activation of caspase-9 and caspase-3, however not caspase-8. In addition, chrysin reduced the expression of anti-apoptotic B cell lymphoma (Bcl) proteins including Bcl-2, Mcl-1, Bcl-xl, and promoted the protein expression of pro-apoptotic Bcl-2 associated X, apoptosis regulator. Chrysin also induced endoplasmic reticulum stress via activation of the unfolded protein response of PRKR-like endoplasmic reticulum kinase, eIF2 and activating transcription factor 4 in bladder cancer cells. Additionally, chrysin inhibited the signal transducer and activator of transcription 3 pathway. Furthermore, the generation of reactive oxygen species (ROS) was detected following treatment with chrysin. The ROS scavenger N-acetylcysteine inhibited the antitumor effect of chrysin. Collectively, these results indicate chrysin may act as a promising therapeutic candidate for targeting bladder cancer.

read more

04:36

These results suggest the potential of chrysin as an anti-cancer drug through the activation of p53 without DNA damage. GreenMedInfo

PMID:  Molecules. 2018 Jun 8 ;23(6). Epub 2018 Jun 8. PMID: 29890668 Abstract Title:  Anti-Tumorigenic Activity of Chrysin fromvia Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway. Abstract:  The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death in response to various cellular stresses, thereby preventing cancer development. Therefore, the activation of p53 through small molecules is an attractive therapeutic strategy for the treatment of cancers retaining wild-type p53. We used a library of 700 Myanmar wild plant extracts to identify small molecules that induce p53 transcriptional activity. A cell-based screening method with a p53-responsive luciferase-reporter assay system revealed that an ethanol extract ofbark increased p53 transcriptional activity. Chrysin was isolated and identified as the active ingredient in thebark extract. A treatment with chrysin increased p53 protein expression and the p53-mediated expression of downstream target genes, and decreased cell viability in MCF7 cells, but not in p53-knockdown MCF7 cells. We also found that chrysin activated the ATM-Chk2 pathway in the absence of DNA damage. Hence, the inactivation of the ATM-Chk2 pathway suppressed p53 activation induced by chrysin. These results suggest the potential of chrysin as an anti-cancer drug through the activation of p53 without DNA damage.

read more

04:24

This study concludes that chrysin confers neuroprotection in animal model of Parkinsons disease. GreenMedInfo

PMID:  Int J Health Sci (Qassim). 2018 May-Jun;12(3):35-43. PMID: 29896070 Abstract Title:  Neuroprotective role of chrysin in attenuating loss of dopaminergic neurons and improving motor, learning and memory functions in rats. Abstract:  Objective: Selective degeneration of dopaminergic neurons is the pathological hallmark of Parkinson disease (PD). Enhanced oxidative stress, lipid peroxidation and susceptibility of dopaminergic neurons to apoptotic cellular death are the leading pathogenetic mechanisms. Chrysin is an active flavonoid. Its neuroprotective effects have been reported. This study examined the neuroprotective effects of chrysin in ameliorating the dopaminergic neuronal degeneration and motor behavioral changes in rotenone model of PD.Methods: Thirty Sprague-Dawley rats were assigned into three groups: Control, rotenone-treated, and rotenone+chrysin treated groups. Rotenone was given at a dose of 3 mg/kg daily intraperitoneally, and chrysin was given at a dose of 50 mg/kg daily intraperitoneally for 4 weeks. Using five neurobehavioral assessment tests, evaluation was done weekly to record the motor behavioral changes. After 4 weeks, animals were sacrificed, brains were removed, and section from striatum and substantia nigra were stained using hematoxylin and eosin and cresyl violet stains. Immunohistochemical sections were also prepared using anti-tyrosine hydroxylase (TH) antibody.Results: Rotenone-induced Parkinson like changes were evident from deteriorating motor behavior. These animals showed extensive loss of dopaminergic neurons, decreased immunoreactivity against anti-TH antibodies and number of TH positive dopaminergic neurons in the nigrostriatal region. Chrysin treated animals showed a significant reduction in motor behavioral changes, degeneration and loss of nigrostriatal dopaminergic neurons and increased immunoreactivity to anti-TH antibody.Conclusion: This study concludes that chrysin confers neuroprotection in rat model of PD. It attenuates the degeneration of the nigrostriatal dopaminergic neurons and motor behavioral abnormalities.

read more

04:14

Chrysin may be a potential replacement for the 5-FU and oxaliplatin combination to achieve antitumor activity through autophagy. GreenMedInfo

PMID:  Int J Mol Sci. 2018 Jun 14 ;19(6). Epub 2018 Jun 14. PMID: 29899208 Abstract Title:  Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin. Abstract:  Chemotherapeutic 5-fluorouracil (5-FU) combined with oxaliplatin is often used as the standard treatment for colorectal cancer (CRC). The disturbing side effects and drug resistance commonly observed in chemotherapy motivate us to develop alternative optimal therapeutic options for CRC treatment. Chrysin, a natural and biologically active flavonoid abundant in propolis, is reported to have antitumor effects on a few CRCs. However, whether and how chrysin achieves similar effectiveness to the 5-FU combination is not clear. In this study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), western blotting, fluorescence microscopy, and reactive oxygen species (ROS) production were assayed. We found that chrysin exhibited similar inhibition of cell viability as the 5-FU combination in a panel of human CRC cells. Furthermore, the results showed that chrysin significantly increased the levels of LC3-II, an autophagy-related marker, in CRC cells, which was not observed with the 5-FU combination. More importantly, blockage of autophagy induction restored chrysin-attenuated CRC cell viability. Further mechanistic analysis revealed that chrysin, not the 5-FU combination, induced ROS generation, and in turn, inhibited the phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR). Collectively, these results imply that chrysin may be a potential replacement for the 5-FU and oxaliplatin combination to achieve antitumor activity through autophagy for CRC treatment in the future.

read more

04:07

Chrysin inhibits advanced glycation end products-induced kidney fibrosis. GreenMedInfo

PMID:  Nutrients. 2018 Jul 9 ;10(7). Epub 2018 Jul 9. PMID: 29987200 Abstract Title:  Chrysin Inhibits Advanced Glycation End Products-Induced Kidney Fibrosis in Renal Mesangial Cells and Diabetic Kidneys. Abstract:  Advanced glycation end products (AGEs) play a causative role in the development of diabetic nephropathy via induction of matrix protein deposition in kidneys. This study investigated inhibitory effects of chrysin, present in bee propolis and herbs, on glomerulosclerosis in db/db mice and AGEs-exposed renal mesangial cells. The in vivo study explored the demoting effects of 10 mg/kg chrysin on glomerular fibrosis in a type 2 diabetic model. Oral supplementation of chrysin inhibited the collagen fiber accumulation and-smooth muscle actin (-SMA) induction in periodic acid schiff-positive renal tissues of db/db mice. Moreover, treating db/db mice with chrysin diminished the level of AGEs increased in diabetic glomeruli. The in vitro study employed human mesangial cells exposed to 100g/mL AGE-BSA for 72 h in the presence of 120M chrysin. Glucose increased mesangial AGE production via induction of receptor for AGEs. Chrysin suppressed the induction of collagens,-SMA, fibroblast-specific protein-1 and matrix metalloproteinases enhanced by AGE-bovine serum albumin. Furthermore, chrysin blunted transforming growth factor-1 induction and Smad 2/3 activation in AGEs-exposed mesangial cells. These results demonstrate that chrysin attenuated accumulation of myofibroblast-like cells and matrix proteins in AGEs-laden diabetic glomeruli. Therefore, chrysin may be a potential renoprotective agent targeting glucose-mediated AGEs-associated glomerulosclerosis and fibrosis.

read more

04:00

Chemopreventive and therapeutic potential of chrysin in cancer. GreenMedInfo

PMID:  Toxicol Lett. 2015 Mar 4 ;233(2):214-25. Epub 2015 Jan 14. PMID: 25596314 Abstract Title:  Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives. Abstract:  Chrysin, a naturally occurring flavone, abundantly found in numerous plant extracts including propolis and in honey is one of the most widely used herbal medicine in Asian countries. Nowadays, chrysin has become the foremost candidate exhibiting health benefits, owing to its multiple bioactivities such as antioxidant, anti-inflammatory, anti-allergic, anti-diabetic, anti-estrogenic, antibacterial and antitumor activities. Anticancer activity is most promising among the multiple pharmacological effects displayed by chrysin. In vitro and in vivo models have shown that chrysin inhibits cancer growth through induction of apoptosis, alteration of cell cycle and inhibition of angiogenesis, invasion and metastasis without causing any toxicity and undesirable side effects to normal cells. Chrysin displays these effects through selective modulation of multiple cell signaling pathways which are linked to inflammation, survival, growth, angiogenesis, invasion and metastasis of cancer cells. This broad spectrum of antitumor activity in conjunction with low toxicity underscores the translational value of chrysin in cancer therapy. The present review highlights the chemopreventive and therapeutic effects, molecular targets and antineoplastic mechanisms that contribute to the observed anticancer activity of chrysin.

read more

03:56

Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion. GreenMedInfo

PMID:  PeerJ. 2018 ;6:e5115. Epub 2018 Jul 3. PMID: 30002964 Abstract Title:  Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion. Abstract:  Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised. Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar and phenolic components, reducing the development of metastatic cancer. Their activity was examined, in PC3 and DU145 prostate cancer cell lines, through measuring the compounds' effects on the metastatic characteristics of migration, invasion and adhesion. First, the phenolic compounds gallic acid, caffeic acid, quercetin, kaempferol and chrysin were quantified in the honeys using high performance liquid chromatography, and found in nanomolar concentrations. In a Boyden chamber-based migration assay, non-toxic concentrations of thyme and honeydew honeys reduced cell migration by 20%, and all phenolic compounds except caffeic acid also lowered migration, although a mixture of only the sugars found in honey had no effect. All of the honeys, phenolics and the sugar-only mixture reduced invasive movement of cells through extracellular matrix by up to 75%. Most notably, each of the three honeys and the sugar-only mixture reduced cell adhesion to collagen I by 90%. With the exception of quercetin, phenolic compounds did not reduce adhesion. Therefore, honey and its sugar and phenolic components can lower the metastatic properties of cancer cells, and may do this by preventing effective cell adhesion to the extracellular matrix. The sugars and phenol compounds of honey are much more effective in combination than individually.

read more

03:18

Parents of Down Syndrome Baby Euthanized by Vanderbilt Hospital Expose Lies of Social Workers in Court Health Impact News

by Health Impact News/MedicalKidnap.com Staff

Could things start to be turning around for the Rivenburg family? At stake in the most recent court hearing was the termination of parental rights for the parents of Annalise Rivenburg, the big sister of deceased Baby Steffen.

While their family and many supporters around the world waited and prayed, Steffen Rivenburg, Sr. and Patricia Tornberg walked into Judge Wayne Sheltons Clarksville, Tennessee, courtroom on Monday, July 11, 2018.

See:

Tennessee Court Seeks to Terminate Parental Rights for Young Sister of Down Syndrome Baby Euthanized by Vanderbilt Hospital

They had been in that courtroom many times, and every time they felt like they were walking into a lions den, facing attorneys, social workers, doctors, Guardian ad Litems (GALs), and a judge, all of whom seemed determined to tear them and their family apart.

This time, however, it was different. Grandmother Lisa Rivenburg, spokesperson for the family, told Health Impact News:

It was epic!

The judge LISTENED to the kids [Steffen, Sr., and Patricia] this time!

This is the first time, since their children were taken from them by the Department of Childrens Services (DCS) on February 2, 2017, that the family has felt that they were listened to in court.

Annalise with grandmother Lisa

Photo provided by family.

They dont know why things changed, but they see this as a huge answer to prayer.

Annalise is still not home with her family, but her parents parental rights have not been severed. For now, she remains in the foster home that she was placed in by DCS, but she is not up for adoption.

The family has bee...

03:06

Parents of Down Syndrome Baby Euthanized by Vanderbilt Hospital Expose Lies of Social Workers in Court Medical Kidnap

by Health Impact News/MedicalKidnap.com Staff

Could things start to be turning around for the Rivenburg family? At stake in the most recent court hearing was the termination of parental rights for the parents of Annalise Rivenburg, the big sister of deceased Baby Steffen.

While their family and many supporters around the world waited and prayed, Steffen Rivenburg, Sr. and Patricia Tornberg walked into Judge Wayne Sheltons Clarksville, Tennessee, courtroom on Monday, July 11, 2018.

See:

Tennessee Court Seeks to Terminate Parental Rights for Young Sister of Down Syndrome Baby Euthanized by Vanderbilt Hospital

They had been in that courtroom many times, and every time they felt like they were walking into a lions den, facing attorneys, social workers, doctors, Guardian ad Litems (GALs), and a judge, all of whom seemed determined to tear them and their family apart.

This time, however, it was different. Grandmother Lisa Rivenburg, spokesperson for the family, told Health Impact News:

It was epic!

The judge LISTENED to the kids [Steffen, Sr., and Patricia] this time!

This is the first time, since their children were taken from them by the Department of Childrens Services (DCS) on February 2, 2017, that the family has felt that they were listened to in court.

Annalise with grandmother Lisa

Photo provided by family.

They dont know why things changed, but they see this as a huge answer to prayer.

Annalise is still not home with her family, but her parents parental rights have not been severed. For now, she remains in the foster home that she was placed in by DCS, but she is not up for adoption.

The family has been f...

00:15

Richard Pan To Propose Heavier Mandatory Vaccine Enforcements As Outbreak Vulnerability Rises Vaxxter

California is notoriously tough on the issue of vaccines. It has been two years since the state enacted draconian mandatory vaccine laws, pushing vaccine rates to the record levels. However, even though by some accounts...

The post Richard Pan To Propose Heavier Mandatory Vaccine Enforcements As Outbreak Vulnerability Rises appeared first on Vaxxter.

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

Sunday, 15 July

21:56

Flutemetamol F 18. Summary of Use during Lactation. Fluoride Action Network

Drug Levels and Effects

Information in this record refers to the use of flutemetamol F 18 as a diagnostic agent. No information is available on the use of flutemetamol F 18 during breastfeeding. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose of 185 MBq (5 mCi). This length of time is about 10 half-lives of fluoride F 18 and less than 0.01% of the radioactivity administered will remain in the body. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1][2][3]

Drug Levels

Fluoride F18 decays by positron emission with a physical half-life of 109.7 minutes.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1 Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www?.nrc.gov/reading-rm?/doc-collections?/nuregs/staff/sr1556/v9/r2/

2 Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: data, quantitative analysis and recommendations. Nucl Med Commun. 1989;10:15-27. [PubMed]

3 Early PJ, Sodee DB. Principles and practice of nuclear medicine. 2nd ed. St. Louis. Mosby-Year Book, Inc. 1995:1380-1.

Substance Identification

Substance Name: Flutemetamol F 18

CAS Registry Number: 765922-62-1

Drug Class

  • Radi...

21:44

Florbetaben F 18: Summary of Use during Lactation. Fluoride Action Network

Drug Levels and Effects

Information in this record refers to the use of florbetaben F 18 as a diagnostic agent. No information is available on the use of florbetaben F 18 during breastfeeding. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose Twenty-four hours is about 10 half-lives of fluoride F 18 and less than 0.01% of the radioactivity administered will remain in the body. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1][2][3]

Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[4]

Drug Levels

Fluoride F18 decays by positron emission with a physical half-life of 109.7 minutes.

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1 Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www?.nrc.gov/reading-rm?/doc-collections?/nuregs/staff/sr1556/v9/r2/

2 Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: data, quantitative analysis and recommendations. Nucl Med Commun. 1989;10:15-27. [PubMed]

3 Early PJ, Sodee DB. Principles and practice of nuclear medicine. 2nd ed. St. Louis. Mosby-Year Book, Inc. 1995:1380-1.

4 Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000;41:863-73. [...

21:27

Sodium Fluoride F 18: Summary of Use during Lactation. Fluoride Action Network

Drug Levels and Effects

Information in this record refers to the use of sodium fluoride F 18 as a diagnostic agent. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose of 300-450 MBq (8 to 12 mCi); however, this time might be longer than necessary given the minimal amount of fluoride that appears in breastmilk. Twenty-four hours is about 10 half-lives of fluoride F 18 and less than 0.01% of the radioactivity administered will remain in the body. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1][2][3]

Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[4]

Drug Levels

Fluoride F18 decays by positron emission with a physical half-life of 109.7 minutes.

Maternal Levels. A study in one mother who received an oral dose of 25 mg of nonradioactive sodium fluoride found that milk fluoride concentrations closely paralleled maternal serum fluoride concentration at 21 to 32% of maternal serum levels over an 8-hour period. The authors estimated that this represents only 0.2% of the dose given to the mother.[5]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1 Howe DB, Beardsley M, Bakhsh S. Appendix U. Model procedure for release of patients or human research subjects administered radioactive materials. In, NUREG-1556. Consolidated guidance about materials licenses. Program-specific guidance about medical use licenses. Final report. U.S. Nuclear Regulatory Commission Office of Nuclear Material Safety and Safeguards. 2008;9, Rev. 2. http://www?.nrc.gov/reading-rm?/doc-collections?/nuregs/staff/sr1556/v9/r2/

2 Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: data, quantitative analysis and recommendations. Nucl Med Commun. 1989;10:15-27. [...

20:46

Letter | Why doesnt Oberon have a full-time dentist? Fluoride Action Network

IN response to the pro-fluoride letter on June 28 by V Clark-Ferraino, the truth is that Colgate University and Manchester University have promoted fluoride products for over 40 years and they established the Cochrane Collaboration. Colgate provided infrastructure as well as academic salaries and prizes associated with the Trendley Dean Medal. Despite this, Cochrane Collaboration has found that fluoride toothpaste less than 1000 ppm and fluoride varnishes provide no benefit compared to non-fluoridated products. So how can 1 ppm in water passing through the mouth in a matter of seconds possibly help?

I repeat the Cochrane Fluoridation findings: There is very little contemporary evidence, meeting the reviews inclusion criteria, that has evaluated the effectiveness of water fluoridation for the prevention of caries. https://bit.ly/2LM85ph (2015). Colgate is now promoting fluoride-free toothpaste for children under six, and some of its competitors warn not to use fluoride for any child under 12.

Local proof that water fluoridation does not work comes from NSW public servants (thats correct, fluoride does not work. My apologies, its just that we obviously need repetition). Tamworth in NSW has been fluoridated for 55 years and is experiencing rampant tooth decay. This was the headline in The Land and The Northern Daily Leader: Rot is setting in tooth decay rife among Tamworth kids. Dental hygienist Mandy Sorensen said: There is definitely an increase in the decay rate and we do see some pretty nasty cases. A report released by Adelaide University found that 40 per cent of Tamworth children in primary school aged five to 10 years had decay in their baby teeth. (Haley Sheridan, May 2016).

To think Oberon does not have a full-time dentist. If we had such enormous decay rates as Bathurst dentists would have us believe, then our population numbers would require at least one full-time dentist, but we dont because there is not enough work.

The very same NSW Health people promoting fluoridation to Oberon in 2014, ie Dr Shanti Sivaneswaran, published a paper that basically says children in fluoridated areas had 1.5 times the damaged permanent teeth compared to non-fluoridated areas. Thats how crazy this gets. Their conclusion was: Gender, water fluoridation, Aboriginal status and parental education were not significant predictors of caries experience. (Zander et al 2013).

More good news for those against water fluoridation: last weeks NZ Supreme Court ruling, confirming the 1964 ruling of Justice Gillard in Victoria, that fluoride is mass-medicatio...

20:00

Autism Siblings: Taking it to the Next Level AGE OF AUTISM

By Cathy Jameson People warned me that the years go by quickly. Boy, were they right! Time really is flying by. Im reminded of that when Ronans big sister checks out a new college. Fionas been checking out colleges for...

15:00

Chiropractic BioPhysics and Gonstead Technique for Spinal Health Articles

By Dr. Mercola

Nearly two years ago, a good friend of mine, Dr. Peter Martone, a longtime chiropractor, pointed out I had some problems with my cervical spine. While I initially disagreed, X-rays revealed degeneration in my fifth and sixth cervical vertebrae, even though I had no symptoms at all.

In this interview, Dr. Michael Hill a graduate of Palmer College in Davenport, Iowa discusses Chiropractic BioPhysics (CBP) and Gonstead, a specific type of chiropractic treatment that addresses this kind of problem. Ive always been opposed to X-rays and dont recommend them. In this case, however, its necessary, as the treatment is precisely calibrated based on the X-ray data.

With chiropractic, one of the big components I like to really help patients understand is where all health and healing comes from, Hill says. We cant deny that the nervous system coordinates all function and healing in the body. If you dont know how to take care of it, whos going to do that for you and help you understand the importance behind it? Education is one of our biggest components in our office.

Chiropractic technique stands on three legs: the philosophy, science and art. If we take one away, its easy to tip over. Weve got to stay solid on those three components Gonstead and CBP have a lot in similarities, but a lot in differences. When it comes to understanding structure dictates function, your spine is basically the framework of everything else that works off of that.

Then its important to understand that we need to identify any structural changes that are compromising the way we should function. The intimate relationship between spine and nervous system is just that. Its intimate if we dont take care of the spine, the [nervous system] is going to fall short of 100 percent function.

Skeletal Structure and Function Influences Your Nervous System

A common assumption is that unless youre experiencing pain, all is well. In reality, many if not most diseases are asymptomatic until the disease process is well underway. As noted by Hill, theres research showing you have to lose 40 percent or greater of your health potential before any sign or symptom is expressed. So, its unfortunate that we are taught to treat and manage disease as opposed to preventing it.

One of the primary tools for maintaining health is to choose the right...

This Buffalo Coleslaw Is Perfect for Your Summer Cookouts Articles

Recipe From Ruled.me
Planning to throw a backyard barbeque party this summer? Take your BBQ to the next level by pairing it with this Buffalo Coleslaw from Ruled.me. Its creamy and crunchy, like a perfect coleslaw should be. But heres the twist: It also packs a spicy and tangy punch that will have you and your guests craving more. Its the perfect side dish to round out the rich flavors of your smoked and grilled meats. Its also quick and easy to make, so try to recreate this crowd-pleasing recipe today.


Ingredients:
1/4 cup mayonnaise
1/4 cup organic hot sauce
1/4 cup apple cider vinegar
1 teaspoon garlic powder
1/2 teaspoon salt
1/2 large green cabbage, thinly sliced
2 large ribs of celery, finely diced
1/2 medium-sized white onion, finely diced
2 tablespoons chopped chives
1 cup grass fed blue cheese, crumbled

Procedure:

  1. In a medium-sized bowl, whisk together the mayonnaise, hot sauce, apple cider vinegar, garlic powder and salt.
  2. In a large mixing bowl, toss together the green cabbage, celery, white onion, half the chives and half the blue cheese.
  3. Add the dressing to the cabbage and toss together.
  4. Serve the coleslaw with a drizzle of hot sauce, and the remaining chives and blue cheese sprinkled on top .

Cabbage Is Loaded With Many Beneficial Nutrients

Cabbage belongs to the cruciferous family of vegetables, along with broccoli, cauliflower and Brussels sprouts. Its known to have cancer-fighting properties, as it contains high amounts of powerful phytochemicals like carotenoids, sulforaphane and isothiocyanates, which may help reduce the production of cancer-related hormones, inhibit tumor growth, induce apoptosis and detoxify carcinogens.
Studies have shown that these compounds in cabbage not only help lower the risk for breast, prostate and colon cancers, but they also help reduce the levels of low-density lipoprotein (LDL) or bad cholesterol in the blood. , In addition, cabbage nourishes your body with many beneficial vitamins and minerals, including:


Thiamin

Calcium...

Introduction to Hypoglycemia Articles

Have you been feeling faint or under the weather after changing your diet, skipping a few meals or going for a few hours more at the gym? If so, theres a chance that youre hypoglycemic. Hypoglycemia is a fairly common condition, especially in the diabetic population, which entails a dramatic decrease in your blood sugar levels. It may cause you to feel dizzy, weak and confused. These articles will focus on what hypoglycemia is, the symptoms you should look out for, and how you can prevent episodes from happening again.

Is Hypoglycemia Dangerous?

For most people, glucose is your primary source of energy, making it one of the most important substances in the body. Unfortunately, there are instances when the body is not able to properly regulate glucose expenditure, exposing you to a variety of conditions, which include hypoglycemia. Relatively, hypoglycemia is not a dangerous condition, as long as you listen to what your body is trying to tell you.

However, there are instances when it may cause extreme complications, which may endanger your life and the lives of the people around you. Severe attacks of hypoglycemia, especially in undiagnosed or unregulated diabetics, may cause seizures, blackouts and fainting spells.1 If youre driving or walking to work, these unexpected blackouts and loss of all motor functions may cause fatal accidents, which may lead to fatal repercussions.2

What Are the Risk Factors for Hypoglycemia?

Like other diseases, certain people are more susceptible to hypoglycemia than others. The risk depends on various external and internal factors, some of which are rooted in their interference with the bodys insulin production and energy expenditure. If you think you may be suffering from hypoglycemia, here are some of the risk factors that you should be looking out for:

Diabetes. Diabetes patients suffer from a relatively higher risk of getting hypoglycemia because of their body's inability to regulate insulin and glucose. This condition is more common in Type 1 diabetes patients because of their dependence on synthetic insulin. When their blood sugar drops to a critical level, they are at high risk for insulin shock, a life-threatening complication of hypoglycemia.3

Increased physical activity. A sudden increase in physical activity, whether during exercise or work, depletes the sugar in the body. This heightens your risk of hypoglycemia, especially if f...

14:46

Mad in Asia: Towards Multiple Narratives for Inclusion Mad In America

An e-zine with the mission to contribute to changing the narrative about madness and mental distress in the Asia region has launched. Mad in Asia hopes to showcase narratives that are contextually relevant to the Asia region, with a focus on the human rights of persons with psychosocial disabilities.

We share the concerns that many activists and advocates around the world have about the dominance of the biomedical model in the understanding, treatment and care of people deemed mentally ill. Many of our countries still operate under the legacy of colonial institutions and legal frameworks set up to manage the mad. Meanwhile, new global movements have set out to create and replicate policies and institutions based on western psychiatry and clinical psychology. Even in the alternatives to psychiatry context, efforts to drive innovations developed in the global north into the global south have sometimes tended to replicate old colonial tendencies.

We believe there is no single all-encompassing way to challenge and change the current narratives and practices that marginalise the experiences of persons with psychosocial disabilities. Nor can it be articulated in terms of an opposition to biomedical psychiatry and its institutions alone. In many of our countries, institutional psychiatry/psychology does not exist, and violation of our rights and personhood takes place within our societies, immediate community spaces and families. Collective action involves a whole range of negotiations as well as the affirmation and validation of knowledge, experiences and skills emerging from and responsive to local contexts. What is required, then, are contextually relevant multiple narratives.

The alliance of persons with psychosocial disabilities and cross disability supporters, TCI Asia (Transforming Communities for Inclusion of Persons with Psychosocial Disabilities, Asia), has been at the forefront of this work in the Asia region. Mad in Asia works in partnership with TCI Asia, aligning our objectives to focus on the human rights and community inclusion of persons with psychosocial disabilities. To change the mental health narrative to one that critically engages with peoples lived experiences in our region, we believe that notions such as community, inclusion, rights, personhood, disability, society as well as madness, mental health and psychiatry need to be examined.

Mad in Asia is a space led by persons with psychosocial disabilities from Asian countries for negotiating and nurturing such narratives. We hope to do this in collaboration with our allies including cross disability activists, mental health workers, academics, social justice campaigners, family and community members, and anyone else interested in joining this online community for change. In doing this, we hope to disseminate the extensive knowledge (theories, investigations, actions...

10:12

Fucoidan inhibits the proliferation of human urinary bladder cancer T24 cells. GreenMedInfo

PMID:  Molecules. 2014 May 9 ;19(5):5981-98. Epub 2014 May 9. PMID: 24818577 Abstract Title:  Fucoidan inhibits the proliferation of human urinary bladder cancer T24 cells by blocking cell cycle progression and inducing apoptosis. Abstract:  Although fucoidan has been shown to exert anticancer activity against several types of cancer cell lines, no reports have explored fucoidan-affected cell growth in human urinary bladder cancer cells. In this study, we investigated the anti-proliferative effects of fucoidan in human bladder cancer T24 cells. Our results indicated that fucoidan decreased the viability of T24 cells through the induction of G1 arrest and apoptosis. Fucoidan-induced G1 arrest is associated with the enhanced expression of the Cdk inhibitor p21WAF1/CIP1 and dephosphorylation of the pRB along with enhanced binding of p21 to Cdk4/6 as well as pRB to the transcription factor E2Fs. Further investigations showed the loss of mitochondrial membrane potential and the release of cytochrome c from mitochondria to cytosol, proving mitochondrial dysfunction upon fucoidan treatment with a corresponding increase in the Bax/Bcl-2 expression ratio. Fucoidan-triggered apoptosis was also accompanied by the up-regulation of Fas and truncated Bid as well as the sequential activation of caspase-8. Furthermore, a significant increased activation of caspase-9/-3 was detected in response to fucoidan treatment with the decreased expression of IAPs and degradation of PARP, whereas a pan-caspase inhibitor significantly suppressed apoptosis and rescued the cell viability reduction. In conclusion, these observations suggest that fucoidan attenuates G1-S phase cell cycle progression and serves as an important mediator of crosstalk between caspase-dependent intrinsic and extrinsic apoptotic pathways in T24 cells.

read more

06:16

Are There Optogenetics, Nano Biology And Blue Light Nexus Health Problems? Natural Blaze

By Catherine J. Frompovich

Optogenetics is something consumers using all types of high tech gadgets need to become fully informed about; the sooner, the better! Using any device that emits light, especially that known as blue light needs to be looked at and considered as a potential health hazard, according to emerging research.

Here are two explanations for Optogenetics:

A technique in neuroscience in which genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals. Optogenetics allows researchers to control how nerve cells communicate

Source: Online Dictionary

Optogenetics is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. Wikipedia [CJF emphases on both]

03:55

Geoengineering Watch Global Alert News, July 14, 2018, #153 Geoengineering Watch

uu7yhDane Wigington GeoengineeringWatch.org Will social media providers continue to ramp up their censorship until a totalitarian state prevails? How many in industrialized nation populations are willing to look beyond the power structure's orchestrated political theater of the absurd? How many are willing to face the wider horizon of what is unfolding around us? Will it take total unraveling of

03:35

In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum. GreenMedInfo

PMID:  Pak J Biol Sci. 2014 Feb 1 ;17(3):402-7. PMID: 24897795 Abstract Title:  In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum. Abstract:  The aim of the present study is conducted to evaluate the antioxidant potential and toxicity effect of polysaccharide-fucoidan from the brown seaweed Sargassum tenerrimum. Fucoidan-a sulphated polysaccharide contains fucose and sulphate as major compounds. Interestingly, various studies reported that the presence of sulphate content of the sample plays a significant role in pharmacological activities. In this study, fucoidan was fractionated by Ion exchange chromatography method and it major chemical constituent sulphate and fucose was determined by the biochemical methods. The toxicity effect of fucoidan was analyzed by the brine shrimp toxicity assay. Three fucoidan fractions (F1, F2 and F3) were obtained from Intact Fucoidan (IF) through anion-exchange column chromatography. In vitro antioxidant capability was analyzed by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radical scavenging and total antioxidant assays and intact fucoidan showed the maximum activity 83.66 +/- 0.35, 81.73 +/- 0.35% and 41.6 +/- 0.43 mg g(-1), respectively. The finding of the present study was confirmed that the antioxidant property of fucoidan was depending upon the sulphate content of the fraction and these studies proved that fucoidan have non toxicity effect. Hence, fucoidan have the scope of being used as natural antioxidants in treating many human diseases.

read more

02:48

Fucoidan is a -amylase inhibitor which is more effective than that of acarbose. GreenMedInfo

PMID:  Int J Biol Macromol. 2015 Nov ;81:644-7. Epub 2015 Sep 9. PMID: 26325676 Abstract Title:  Fucoidan - An-amylase inhibitor from Sargassum wightii with relevance to NIDDM. Abstract:  The present experiment was conducted to screen the-amylase inhibitory activity of fucoidan extracted from Sargassum wightii collected at the coastal area of Mandapam, Tamil Nadu, India. Fucoidan was extracted from the sporophyll of S. Wightii by ethanol and CaCl2 precipitation method. The average yield was 1.80.16% and the extracted fucoidan was found to contain 530.52% of fucose and 360.60% of sulphate. Structural elucidation (FT-IR and NMR) and in vitro -amylase activity of purified fucoidon were performed. Fucoidan at the concentration of 62.5, 125 and 250g exhibited 24.81, 62.50 and 99.24% inhibition against -amylase, respectively, in a dose dependent manner. Fucoidan from S. wightii also inhibits -glucosidase which clearly indicates dual inhibitory activity of the compound. The IC50 value against -amylase of fucoidan is found to be 103.83g which is more effective than that of acarbose (16mg).

read more

02:40

These findings provide basic molecular information on the effect of fucoidan on angiogenesis in the presence of FGF-2. GreenMedInfo

PMID:  Biochem Biophys Res Commun. 2014 Aug 8 ;450(4):1333-8. Epub 2014 Jul 5. PMID: 25003321 Abstract Title:  Fucoidan/FGF-2 induces angiogenesis through JNK- and p38-mediated activation of AKT/MMP-2 signalling. Abstract:  Angiogenesis is an important biological process in tissue development and repair. Fucoidan has previously been shown to potentiate in vitro tube formation in the presence of basic fibroblast growth factor (FGF-2). However, the underlying molecular mechanism remains largely unknown. This study was designed to investigate the action of fucoidan in angiogenesis in human umbilical vein endothelial cells (HUVECs) and to explore fucoidan-signalling pathways. First, we evaluated the effect of fucoidan on cell proliferation. Matrigel-based tube formation and wound healing assays were performed to investigate angiogenesis. Matrix metalloproteinase-2 (MMP-2) mRNA expression and activity levels were analysed by reverse transcription polymerase chain reaction (RT-PCR) and zymography, respectively. Additionally, phosphorylation of mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) was detected by Western blot. The results indicate that fucoidan treatment significantly increased cell proliferation in the presence of FGF-2. Moreover, compared to the effect of FGF-2 alone, fucoidan and FGF-2 had a greater effect on tube formation and cell migration, and this effect was found to be synergistic. Furthermore, fucoidan enhanced the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38, and AKT. MMP-2 activation was also significantly increased. Specific inhibitors of p38 (SB203580) and JNK (SP600125) inhibited tube formation and wound healing, while an ERK inhibitor (PD98059) did not. MMP-2 activation and AKT phosphorylation were also attenuated and associated with the suppression of p38 and JNK phosphorylation, but not with that of ERK. These results indicate that fucoidan, in the presence of FGF-2, induces angiogenesis through AKT/MMP-2 signalling by activating p38 and JNK. These findings provide basic molecular information on the effect of fucoidan on angiogenesis in the presence of FGF-2.

read more

02:32

Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. GreenMedInfo

PMID:  PLoS One. 2014 ;9(9):e108157. Epub 2014 Sep 18. PMID: 25232957 Abstract Title:  Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. Abstract:  BACKGROUND: Cancer metastasis is the main cause leading to disease recurrence and high mortality in cancer patients. Therefore, inhibiting metastasis process or killing metastatic cancer cells by inducing apoptosis is of clinical importance in improving cancer patient survival. Previous studies revealed that fucoidan, a fucose-rich polysaccharide isolated from marine brown alga, is a promising natural product with significant anti-cancer activity. However, little is known about the role of endoplasmic reticulum (ER) stress in fucoidan-induced cell apoptosis.PRINCIPAL FINDINGS: We reported that fucoidan treatment inhibits cell growth and induces apoptosis in cancer cells. Fucoidan treatments resulted in down-regulation of the glucose regulated protein 78 (GRP78) in the metastatic MDA-MB-231 breast cancer cells, and of the ER protein 29 (ERp29) in the metastatic HCT116 colon cancer cells. However, fucoidan treatment promoted ER Ca2+-dependent calmodulin-dependent kinase II (CaMKII) phosphorylation, Bcl-associated X protein (Bax) and caspase 12 expression in MDA-MB-231 cells, but not in HCT116 cells. In both types of cancer cells, fucoidan activated the phosphorylation of eukaryotic initiation factor 2 alpha (p-eIF2)\CCAAT/enhancer binding protein homologous protein (CHOP) pro-apoptotic cascade and inhibited the phosphorylation of inositol-requiring kinase 1 (p-IRE-1)\X-box binding proteins 1 splicing (XBP-1s) pro-survival cascade. Furthermore, CHOP knockdown prevented DNA damage and cell death induced by fucoidan.CONCLUSION/SIGNIFICANCE: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its anti-tumour activity and provides evidence for the therapeutic application of fucoidan in cancer.

read more

02:11

Fucoidan may be considered for use in improving obesity. GreenMedInfo

PMID:  Phytother Res. 2014 Jan ;28(1):137-43. Epub 2013 Apr 12. PMID: 23580241 Abstract Title:  Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation. Abstract:  This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity.

read more

02:07

A review of fucoidan as a marine anticancer agent in preclinical development. GreenMedInfo

PMID:  Mar Drugs. 2014 Jan 28 ;12(2):851-70. Epub 2014 Jan 28. PMID: 24477286 Abstract Title:  Fucoidan as a marine anticancer agent in preclinical development. Abstract:  Fucoidan is a fucose-containing sulfated polysaccharide derived from brown seaweeds, crude extracts of which are commercially available as nutritional supplements. Recent studies have demonstrated antiproliferative, antiangiogenic, and anticancer properties of fucoidan in vitro. Accordingly, the anticancer effects of fucoidan have been shown to vary depending on its structure, while it can target multiple receptors or signaling molecules in various cell types, including tumor cells and immune cells. Low toxicity and the in vitro effects of fucoidan mentioned above make it a suitable agent for cancer prevention or treatment. However, preclinical development of natural marine products requires in vivo examination of purified compounds in animal tumor models. This review discusses the effects of systemic and local administration of fucoidan on tumor growth, angiogenesis, and immune reaction and whether in vivo and in vitro results are likely applicable to the development of fucoidan as a marine anticancer drug.

read more

01:49

Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. GreenMedInfo

PMID:  CNS Neurosci Ther. 2014 Dec ;20(12):1036-44. Epub 2014 Nov 15. PMID: 25399812 Abstract Title:  Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: Role of NADPH oxidase-1. Abstract:  AIMS: To explore the effect of fucoidan treatment on oxidative stress-mediated dopaminergic neuronal damage and its potential mechanisms.METHODS: The effect of fucoidan was investigated in a 6-hydroxydopamine (6-OHDA) rat model of PD, an animal model considered appropriate for preclinical studies of PD therapy. The effects of fucoidan treatment on animal behavior and the survival ratio of dopaminergic neurons were investigated. We further observed the effect of fucoidan on microglia and the NADPH oxidases-1 (Nox1), a family of enzymes generating reactive oxygen species (ROS).RESULTS: We found that chronic fucoidan administration mitigated the motor dysfunction induced by 6-OHDA. Similarly, fucoidan reduced the loss of DA neurons in the SNc and DA fibers in the striatum in 6-OHDA-lesioned rats. Moreover, we found that fucoidan inhibited the 6-OHDA-stimulating expression of Nox1 in both tyrosine hydroxylase (TH)-positive neurons and non-TH-positive neurons, prevented Nox1-sensitive oxidative stress and cell damage in SNc neurons. Fucoidan also effectively inhibited nigral microglial activation.CONCLUSION: These results support the beneficial effect of fucoidan in 6-OHDA-lesioned rat model of PD. Fucoidan may suppress the Nox1-triggered oxidative stress in the SNc to protect DA neurons from 6-OHDA-induced toxicity and achieve its beneficial effect.

read more

01:41

Sheridan: Fluoride, Handbook, on Councils Agenda Fluoride Action Network

The Sheridan City Council at their regularly scheduled meeting Monday night will be discussing a handbook for the Mayor and Council. Sheridan Mayor Roger Miller says that this is something hes been seeking for quite awhile.

Mayor Miller says that the issue of fluoridation of water at the water treatment plants will be addressed in the form of two separate resolutions, the first of which would put the question on the ballot in November, and the second addresses a proposed public opinion survey on water fluoridation.

The Council will meet at 7 pm Monday night on the third floor of City Hall in Council Chambers. A live broadcast of the meeting will be available on AM-1410 KWYO.

*Original article online at https://www.sheridanmedia.com/news/fluoride-handbook-council-s-agenda99579

01:14

FaceBooks War Against Judeo/Christian America BolenReport

4.7 Million Hindus and Muslims, In The US On H-1B Work Visas, Dominate Social Media Decisions Opinion by Deplorable Consumer Advocate Tim Bolen   A January 17th, 2018 article in the San Jose Mercury News titled H-1B: Foreign citizens make up nearly three-quarters of Silicon Valley tech workforce, report says  spilled the beans on FaceBook, Google Continue reading FaceBooks War Against Judeo/Christian America

The post FaceBooks War Against Judeo/Christian America appeared first on BolenReport.

00:41

Fucoidan ameliorated the development of high fat diet-induced NAFLD. GreenMedInfo

PMID:  Environ Toxicol Pharmacol. 2015 Nov ;40(3):907-14. Epub 2015 Oct 23. PMID: 26498267 Abstract Title:  Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease. Abstract:  Fucoidan, a sulfated polysaccharide derived from brown seaweeds, possesses a wide range of pharmacological properties. In the present study, we investigated the therapeutic effect of fucoidan on non-alcoholic fatty liver disease (NAFLD) in rats. Rats were fed a high-fat diet (HFD) for 12 weeks to induce NAFLD. Oral administrations of fucoidan (100mg/kg, orally), metformin (200mg/kg, orally) or the vehicle were started in the last four weeks. Results showed that administration of fucoidan for 4 weeks attenuated the development of NAFLD as evidenced by the significant decrease in liver index, serum liver enzymes activities, serum total cholesterol and triglycerides, fasting serum glucose, insulin, insulin resistance, and body composition index. Further, fucoidan decreased hepatic malondialdehyde as well as nitric oxide concentrations, and concomitantly increased hepatic reduced glutathione level. In addition, the effect of fucoidan was accompanied with significant decrease in hepatic mRNA expressions of tumor necrosis factor-, interleukins-1 and matrix metalloproteinase-2. Furthermore, histopathological examination confirmed the effect of fucoidan. In conclusion, fucoidan ameliorated the development of HFD-induced NAFLD in rats that may be, at least partly, related to its hypolipidemic, insulin sensitizing, antioxidant and anti-inflammatory mechanisms.

read more

Saturday, 14 July

01:34

Study Will Measure Quality Of Northern Wisconsin Groundwater Fluoride Action Network

First-Ever Private Well Testing Will Measure Fluoride, Metal Levels In 11 Counties

A first-of-its-kind groundwater quality study in 11 northern Wisconsin counties will focus on whats in the drinking water of private wells.

The University of Wisconsin-Superiors Lake Superior Research Institute has received a nearly $56,000 grant from the Wisconsin Department of Natural Resources to conduct the voluntary 18-month study.

We have in northwestern Wisconsin a really large proportion of people that are on (private) well water. I think were pretty unique in that way, said Kelsey Prihoda, a researcher with the Lake Superior Research Institute who is leading the study. Private wells, theres no requirement that they be monitored, as opposed to a public wells.

The goal is to collect 700 water samples from private wells in the 11 counties. The level of fluoride will be measured in each sample. Prihoda said they want to find out if most of the water contains .7-1.5 miligrams per liter of fluoride which is thought to be a healthy level to consume for good teeth and bone development.

If its less than that, then it actually is conducive to having some sort of a dental cavity, tooth decay sort of thing. So, we would want in that situation to supplement with some sort of a fluoride varnish or fluoride treatment, she said. If its above that, thats where you start to see issues on the other end of the spectrum where there are some malformations in the enamel on teeth.

The study will also look at metal levels in about 10 samples per county like arsenic, iron, magnesium and aluminum to form a baseline of data that can be used in future groundwater studies in northern Wisconsin.

If in the future, there are big industries that come in, or some sort of contaminant level occurrence that would affect our groundwater, we would be able to know what changes had occurred based on human impacts on groundwater, she said.

While this may be the first time the groundwater quality of private wells has been studied in northern Wisconsin, groundwater quality has become...

IndyWatch Health Watch Feed Archiver

Go Back:30 Days | 7 Days | 2 Days | 1 Day

IndyWatch Health Watch Feed Today.

Go Forward:1 Day | 2 Days | 7 Days | 30 Days

IndyWatch Health Watch Feed was generated at Community Resources IndyWatch.

Resource generated at IndyWatch using aliasfeed and rawdog