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Saturday, 20 January

22:02

Video Games on a Psychoanalysts Couch Mad In America

From Asia Times: In his new book The Playstation Dreamworld, Alfie Brown discusses the role of video games in both reinforcing and challenging capitalism through the lens of Freudian dream analysis.

Video games are a form of enjoyment in which the player experiences the wishes and desires of another as the wishes and desires of the players own, if even in a momentary or unconscious way, Bown claims.

Games are experienced actively rather than passively, and any apparent agency over a game is illusory as the player controls neither the environment nor the plot or outcome, as in dreams.

Just as a misreading of dreams can lead one into falsely believing things about oneself, video games are most dangerous in their capacity to force a desire onto the player while misleading them into thinking of it as their own.

Article

22:01

Kelli Foulkrod: Integrating Yoga with Psychotherapy Mad In America

This week on MIA Radio, we interview Kelli Foulkrod. Kelli is the owner of the Organic Mental Health Center.  She is a therapist, yoga teacher, and mental health paradigm shifter based in Austin, Texas.  For the past 15 years, Kelli has worked in the mental health field and practised yoga. She has been integrating yoga and the healing arts into traditional psychotherapy for over eight years and is passionate about offering holistic mental health treatment options.

With many years experience in an academic research setting, Kelli bridges the gap between science and spirituality.  Kelli has experience serving clients populations of pregnant and postpartum women, grief and loss, psychosis, homelessness, substance abuse, teens, couples, and groups.  She offers individual, couples, and group psychotherapy services in addition to yoga therapy sessions, workshops, and retreats.

In the episode we discuss:

  • How Kelli started her journey as a psychology undergraduate at the University of Texas and working in clinical and academic research.
  • How working in a neuroscience laboratory resulted in internal conflict and led Kelli to interest in and research into alternative modalities alongside her psychology studies.
  • How Kelli experienced first hand the approaches that pharmaceutical manufacturers used when running clinical trials.
  • That Kelli felt that modern psychology neglects the body and she started to practise yoga and meditation alongside studying for her Masters degree in clinical psychology.
  • That, to Kelli, modern mental health therapy feels egotistical and narcissistic and that she was resistant to becoming a clinical therapist.
  • How people are hungry for alternatives but there are so few other options that people continue to get involved with mainstream medicine.
  • The profound changes that occur when becoming parents and why this might lead to mental health difficulties.
  • How we have lost touch with community and social connections that existed when we lived as tribal cultures.
  • How shamanic ceremony and tradition can be understood and utilised in response to emotional distress.

Relevant links:

The Organic Mental Health Centre

The Organic Mental Health Centre (Facebook)

Yoga for depression the researc...

22:01

Is Everything Johann Hari Knows About Depression Wrong? Mad In America

In this piece for The Guardian, Dean Burnett critiques Johann Haris new book challenging what we know about depression. According to Burnett, many of the points Hari presents as fringe or new information are already widely accepted.

Hari does make several valid points, in his defence. The claim that depression is purely a result of lowered serotonin levels is indeed one that can and should be challenged. Antidepressant use isnt effective for everyone, and even if youre taking them the problem theyre supposed to be addressing can often return or eventually get worse. External factors in your life can be a big part, if not the main part, of an eventual depression diagnosis. This is all true.

However, despite Haris prose suggesting hes uncovered numerous revelations, pretty much everything he reveals is well known already.

22:00

Best of Dan Olmsted: Weekly Wrap January 21, 2017 AGE OF AUTISM

Note: About a year has passed since our dear Dan Olmsted, leader of the Rebel Alliance, died. Feels to me as crushing as when Dumbledore died in the Harry Potter stories. Just an unfathomable blow. Below is the last Weekly...

17:00

Is it Normal for Joints to Pop, Creak and Crack? Articles

By Dr. Mercola

If the popping or cracking sounds of your joints have ever given you cause for worry, youll be relieved to know that it is normal for your joints to occasionally talk to you. It is common to hear occasional joint sounds when you move in everyday ways, such as bending over to retrieve a dropped item or walking up or down stairs. Dr. William Shiel, chief editor and co-founder of the medical-information website MedicineNet.com, says:1

The symptom of joint cracking is described differently by different people, while nevertheless representing the same condition. Various descriptions for the same process include popping, exploding, noise, snapping and creaking of a joint.

The most common and less serious joint popping that occurs most often is caused by knuckle cracking or a certain manner of bending or twisting the body to relieve pressure.

One cause for the sounds is the reality that your soft tissues, such as ligaments and tendons, frequently contact your bones and other tissues as you move. Pockets of nitrogen gas within your joint fluid, which help with joint lubrication and nutrition, can also be responsible for some of the sounds.

To date there is insufficient evidence linking joint sounds and arthritis. Furthermore, cracking your joints does not cause them to swell up or become arthritic. That said, unless you are experiencing pain and swelling, rest assured that most joint sounds generally are normal, not harmful.

What Are Your Joints Trying to Tell You?

Dr. Aman Dhawan, an orthopedic sports-medicine specialist at Penn State Health Milton S. Hershey Medical Center, says, Joint sounds are not really an indicator of health or lack of health.2

In terms of cracking your joints, there is insufficient evidence to support the belief that it causes cartilage to wear down or that it will permanently loosen the joints. It may be irritating to the listener, but thats a separate issue, Dhawan notes. There is really no evidence that it causes any damage.3 As you may imagine, noisy joints can be of concern if the sounds are unusual or they are accompanied by acute pain and swelling. Some of the more serious joint conditions that may be indicated by...

Grounding A Simple, Pleasurable Way to Reduce Inflammation and Chronic Disease Articles

30 Tips in 30 Days Designed to Help You Take Control of Your Health

This article is part of the 30 Day Resolution Guide series. Each day a new tip will be added designed to help you take control of your health. For a complete list of the tips click HERE

By Dr. Mercola

Did you know the energy from the Earth can help you live a healthier life? The concept is known as earthing or grounding, which is no more complicated than walking barefoot.

In "Down to Earth"1 which received the IndieFEST Award of Excellence for a documentary short in January 20172 I speak alongside other experts to shed light on this super simple yet commonly overlooked way to protect and improve human health. As cardiologist Dr. Stephen Sinatra, author of "Earthing: The Most Important Health Discovery Ever?" explains in the film:

"[G]rounding is literally putting your bare feet on the ground. When you do that, you're in contact with the Earth, and mother Earth is endowed with electrons, and these electrons are literally absorbed through your feet. It's like taking handfuls of antioxidants, but you're getting it through your feet."

Your Body Needs Grounding

Research suggests a general lack of grounding, also referred to as "electron deficiency syndrome," has a lot to do with the rise of modern diseases. For a visual demonstration of this concept, see this previous article, which features an experiment conducted by Gary Schwartz, Ph.D., at the University of Arizona. Using sunflowers, he demonstrates the biological effects of grounding and what happens when the flowers are not grounded.

It's not unusual for Americans to spend entire days without being grounded. But though it has become the norm, it's completely unnatural, and didn't really become widespread until the advent of shoes with artificial soles that prevent grounding. When you're grounded, free electrons from the Earth are transferred into your body, and these free electrons are among the most potent antioxidants known to man.

As electrons are negatively charged and free radicals are positively charged, any free radicals encountered in your tissues are e...

14:38

Changed expressions of N-methyl-D-aspartate receptors in the brains of rats and primary neurons exposed to high level of fluoride Fluoride Action Network

4. Discussion
the numbers of Nissl bodies in neurons in the hippocampus and cortex of
brains from both adult rats and their pups with fluorosis were lowered.
Such reduction in Nissl bodies, showing large granular bodies consisting
of rough endoplasmic reticulum with rosettes of free ribosomes
carrying out protein synthesis, indicates injury of neurons [23].

14:22

Neurotoxicity induced by Fluoride in Rat Cerebral Cortex Fluoride Action Network

In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in neuroplasm and others were showing necrosis. Some granule cells were swollen in shape and size (Fig. 5).

In rats treated with 200 ppm of sodium fluoride, the blood capillaries were constricted with narrow lumen and perivascular empty spaces were observed in the cerebral cortex.

Some glial cells appeared as darkly stained with dot like shrunken nuclei and empty spaces around them (Fig. 8).

The neuronal degeneration and hypertrophy with perineuronal empty spaces were visible in the pyramidal neuron (Fig. 11). In cerebral cortex, some area showed necrosis with complete disintegration of neuropil accompanied by loss of glial cells (Fig.12).

The pyramidal neurons in some area showed hyperchromatic and hypertrophic nucleus that was filling entire neuroplasm (Fig. 13). There were visible rounded fluid filled areas showing gliosis having debris of glial cells. The pyramidal neurons were distorted with spindle shape structure having elongated nucleus (Fig. 14).

In rats treated with 300 ppm of sodium fluoride, cerebral cortex contained the glial cells that were small, deeply stained and dot like structure with vacuolated areas around them (Fig. 15). The neuropil showed degeneration in the form of spiral structure surrounded by microglial cells (Fig. 16). At some locations eosinophilic neurons were visible in neuropil. Area of neuroplasm of some neuron was covered by darkly stained swollen large sized nucleus. Clear halos were visible around some neurons (Fig. 17). A few neurons exhibited degeneration at some locations in neuropil (Fig. 18). In some pyramidal neurons distorted nuclei were shifted to periphery. Chromatolysis visible in some granule cells (Fig. 19).

13:43

The combination of pomegranate juice and tolbutamide exhibited profound protection compared to tolbutamide alone against diabetic complications. GreenMedInfo

PMID:  Integr Med Res. 2017 Dec ;6(4):354-360. Epub 2017 Aug 1. PMID: 29296562 Abstract Title:  The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats. Abstract:  Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications.Methods: Diabetes was induced via administration of alloxan (150 mg/kg, intraperitoneally). Rats (n = 8) were treated with pomegranate juice (PJ) [3 mL/animal, per os (p.o.)], TOL (20 mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method.Results: The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL.Conclusion: From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction.

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13:26

Pomegranate juice supplementation significantly decreased the incidence of lung cancer. GreenMedInfo

PMID:  Oxid Med Cell Longev. 2017 ;2017:6063201. Epub 2017 Nov 30. PMID: 29333211 Abstract Title:  Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Abstract:  Background: Cigarette smoke (CS) induces an oxidative stress, DNA damage, and lung cancer. Pomegranate juice (PJ) possess potent antioxidant activity attributed to its polyphenols. We investigated whether PJ supplementation would prevent the formation of lung nodules, attenuate mitotic activity, and reduce hypoxia-inducible factor-1 (HIF-1) expression secondary to CS exposure in an animal model.Methods: Mice were divided into: Control group, CS group, CS+PJ group, and PJ-only group. CS and CS+PJ were exposed to CS, 5 days per week, for a total of 5 months. Animals were then housed for additional four months. CS+PJ and PJ groups received PJ throughout the experiment period while others received placebo. At the end of the experiment, the incidence of lung nodules was assessed by (1) histological analysis, (2) mitotic activity [measurement of PHH3 antibodies], and (3) measurement of HIF-1 expression.Results: The incidence of lung nodules was significantly increased in CS. CS exposure significantly increased PHH3 and HIF-1 expression. PJ supplementation attenuated the formation of lung nodules and reduced PHH3 and HIF-1 expression.Conclusion: PJ supplementation significantly decreased the incidence of lung cancer, secondary to CS, prevented the formation of lung nodules, and reduced mitotic activity and HIF-1 expression in an animal model.

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13:01

No takers for poll-bound Bijepur fluorosis issue Fluoride Action Network

Fluoride has become a menace for the people of Sandhibahal and Dangbahal gram panchayats under the Bijepur Assembly constituency in Bargarh district, which is going for a by-election.

Most people here are suffering from a silent killer disease called fluorosis, but the pre-election propaganda by different political parties does not reveal that they are in anyway concerned at all of this long standing problem of the people.

Take the case of Jamutbahal, Jadamunda and Banchhanagar villages of Sandhibahal panchayat, where people irrespective of their ages have been affected by the dreaded disease. The official website on the National Rural Drinking Water Projects (NRDWP) of the Union Ministry of Drinking Water Supply (MDWS) reveals that six out of ten drinking water sources of the Jamutbahal village are not fit for drinking. But due to non-availability of any other secured sources, the villagers here are forced to drink the water of these contaminated sources.

Likewise, in Banchhanagar village, one of the four hand pumps is functional and considered to be safe. Chakradihi village has six tube wells, out of which only one is functional. Problems in all other villages of the panchayat are alike. Test reports of water samples of some of the sources tested in the district headquarters water testing lab reveal that most of the sources are above the permissible level of 1.5 mg/L fluoride content.

The water sources in these panchayats have been created under three schemes the PWS scheme, Hand pump scheme and Open well/other scheme. Hand pump scheme has the highest number of sources. In Sandhibahal panchayat, there are 39 hand pumps and two PWS sources. About Rs 1.29 crore has been spent in total in creation of water facilities in the panchayat till now.

There are 44 drinking water sources in Dangbahal GP, which includes one PWS project. An amount of Rs 29.37 lakh has been spent in creation of these sources. But the problems remain intact. Unless the drinking water sources are changed the problems would remain, say the villagers.

The impact of fluoride is clearly visible in people, even within children. Almost all the children have disfigured/stained teeth, which can be considered the beginning of fluorosis. Although the skeletal deformities are visible in people above 30 years, the symptoms start in their twenties. The people reveal that, it all starts from pain in waist and joints which gradually converts to stiffness and deformity.

Laxman Haripal of Banchhanagar village is only 25 yars old, but fluorosis has already deformed his arms. Bhanati Mahapatra (27) has severe pain in her waist, and she cannot bend. Digambar Rana, in his late twenties, has pain in his heels and so, has difficulty in walking. Dilip Mahapatra in early thirties has pain in knee and waist. He is unable to bend his waist due to pain.

By the time, one crosses 40 years of age, his/her deformity increas...

12:40

Long-term rotating night-shift work was associated with a higher risk of breast cancer. GreenMedInfo

PMID:  Am J Epidemiol. 2017 Sep 1 ;186(5):532-540. PMID: 28541391 Abstract Title:  Rotating Night-Shift Work and the Risk of Breast Cancer in the Nurses' Health Studies. Abstract:  In 2007, the International Agency for Research on Cancer declared shift work that involved circadian disruption to be a"probable"carcinogen (group 2A), noting that human evidence was limited. Using data from 2 prospective cohort studies, the Nurses' Health Study (1988-2012; n = 78,516) and Nurses' Health Study II (1989-2013; n = 114,559), we examined associations between rotating night-shift work and breast cancer risk. In the 2 cohorts, there were a total of 9,541 incident invasive breast malignancies and 24 years of follow-up. In the Nurses' Health Study, women with 30 years or more of shift work did not have a higher risk of breast cancer (hazard ratio (HR) = 0.95, 95% confidence interval (95% CI): 0.77, 1.17; P for trend = 0.63) compared with those who never did shift work, although follow-up occurred primarily after retirement from shift work. Among participants in the Nurses' Health Study II, who were younger than participants in the other cohort, the risk of breast cancer was significantly higher in women with 20 years or more of shift work at baseline, reflecting young-adult exposure (HR = 2.15, 95% CI: 1.23, 3.73; P for trend = 0.23), and was marginally significantly higher for women with 20 years or more of cumulative shift work when we used updated exposure information (HR = 1.40, 95% CI: 1.00, 1.97; P for trend = 0.74). In conclusion, long-term rotating night-shift work was associated with a higher risk of breast cancer, particularly among women who performed shift work during young adulthood. Further studies should explore the role of shift work timing on breast cancer risk.

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12:35

11:38

Dr. Sebi Says NO To Parsley Audio Bite #17 Advocates for Dr. Sebi

Dr. Sebi spoke against parsley. However, it once ended up on the list and can probably be seen on other lists that are presented as foods recommended by Dr. Sebi. Recommended food lists from a Dr. Sebi perspective will need a comprehensive review because of at least two reasons: (1) Continue reading

11:33

Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. GreenMedInfo

PMID:  Toxicol Lett. 2018 Jan 2 ;285:81-86. Epub 2018 Jan 2. PMID: 29305326 Abstract Title:  Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. Abstract:  Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500g 50l-1 oil (B500), or 50g 50l-1 (B50), or 5g 50l-1 (B5). Controls were injected with 50l vehicle during the same period. Neonatal exposure to BPA did not modify TSH levels in PND13 females, but it increased them in adults in estrus. Serum T4 was lower in B5 and B500 with regards to Control, whereas no difference was seen in T3. No significant differences were observed in TRH, TSH and TRH receptor expression between groups. TSH release from PPC obtained from adults in estrus was also higher in B50 with regard to Control. In vitro 24h pre-treatment with BPA or E2 increased basal TSH as well as prolactin release. On the other hand, both BPA and E2 lowered the response to TRH. The results presented here show that the neonatal exposure to BPA alters the hypothalamic pituitary-thyroid axis in adult rats in estrus, possibly with effects on the pituitaryand thyroid. They also show that BPA alters TSH release from rat PPC through direct actions on the pituitary.

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11:24

Burn Fat for Fuel new research findings two

Burn Fat for Fuel

  • 697 
  • January 19, 2018 103,003 views
  • Edition: English













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Story at-a-glance
  • Low-fat, high-carb diets prevent healthy mitochondrial function, thereby contributing to chronic diseases such as obesity, Type 2 diabetes, heart disease, Alzheimers, cancer and more
  • Studies suggest low-carb, high-fat diets and eating less frequently may be the answer to the obesity epidemic. The benefits of this type of diet is the primary focus of my book Fat for Fuel, and my complementary online course
  • When your body is able to burn fat for fuel, your liver creates water-soluble fats called ketones that burn far more efficiently than carbs, thus creating far less damaging reactive oxygen species and secondary free radicals
  • Multiday water fasting activates autophagy, allowing your body to clean itself out, and triggers the regeneration of stem cells. Having as little as 200 or 300 calories a day is enough to abort the autophagy process
  • Fasting has been shown to trigger the regeneration of the pancreas in both Type 1 and Type 2 diabe...

11:22

This study reveals a possible role of bisphenol A as an environmental factor involved in the promotion of NAFLD, particularly in T2DM patients. GreenMedInfo

PMID:  Aliment Pharmacol Ther. 2018 Jan 11. Epub 2018 Jan 11. PMID: 29322544 Abstract Title:  Role of bisphenol A as environmental factor in the promotion of non-alcoholic fatty liver disease: in vitro and clinical study. Abstract:  BACKGROUND: Bisphenol A is an endocrine disrupting chemical associated with type 2 diabetes mellitus (T2DM), cardiovascular disease and liver enzyme abnormalities.AIM: To evaluate bisphenol A plasma and urine levels in non-alcoholic fatty liver disease (NAFLD) patients compared to healthy subjects. Furthermore, we evaluated, in human HepG2 cells, the effects of exposure to different concentrations of bisphenol A on both oxidative stress induction and cell proliferation.METHODS: We enrolled 60 patients with histological diagnosis of NAFLD with or without T2DM and sixty healthy subjects. In vitro, the proliferation of bisphenol A-exposed HepG2 cells at two different concentrations (0.025 and 0.05 M) was evaluated, both at high (H-HepG2) and at low (L-HepG2) glucose concentrations for 48 h. Lipoperoxidation was assessed by thiobarbituric acid reactive substances (TBARS) assay.RESULTS: Bisphenol A levels were significantly higher in 60 NAFLD subjects, both in urine and in plasma (P 

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11:09

Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial-mesenchymal transition in aged rats. GreenMedInfo

PMID:  Sci Rep. 2018 Jan 11 ;8(1):490. Epub 2018 Jan 11. PMID: 29323181 Abstract Title:  Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial-mesenchymal transition in aged rats. Abstract:  Bisphenol A (BPA) is a well-known endocrine disruptor compound reported to have prostate toxicity. This study aimed to assess the effect of BPA on the proliferation of dorsolateral prostate (DLP) and the expression of epithelial-mesenchymal transition (EMT)-related genes in aged rats. Male aged SD rats were treated with BPA (10.0, 30.0, and 90.0g/kg i.g., daily) or vehicle (i.g., daily) for 3 months. Treatment with BPA resulted in increased the expression of PCNA, DLP weight and DLP epithelial height compared with the control group (P

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10:41

Sodium fluoride disturbs DNA methylation of NNAT and declines oocyte quality by impairing glucose transport in porcine oocytes. GreenMedInfo

PMID:  Environ Mol Mutagen. 2017 Dec 29. Epub 2017 Dec 29. PMID: 29285797 Abstract Title:  Sodium fluoride disturbs DNA methylation of NNAT and declines oocyte quality by impairing glucose transport in porcine oocytes. Abstract:  Sodium fluoride (NaF) is used as a medicine to prevent tooth decay; however, excessive NaF could cause a pathological damage to the health. Recent studies showed that NaF impaired mouse oocyte maturation, included of abnormal spindle configuration, actin cap formation, cortical granule-free domain formation, and the following development after fertilization. However, few studies used large animals as models to study the toxicology of NaF on oocytes maturation. We proposed a hypothesis that NaF would affect the nuclear and cytoplasmic maturation of porcine oocytes and DNA methylation pattern of imprinted genes in oocytes. Our results showed that NaF affected cumulus expansion, polar body emission, spindle morphology, cortical granule distribution, early apoptosis, and the following development after parthenogenetic activation during porcine oocyte maturation. Moreover, NaF increased the DNA methylation of NNAT and decreased its expression, which disturbed the glucose transport in oocytes. These results suggest that NaF impairs the porcine oocytes maturation epigenetically, which provides a new toxicological mechanism of NaF on the oocyte maturation. Environ. Mol. Mutagen, 2017. 2017 Wiley Periodicals, Inc.

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09:36

This study suggests that night work is associated with reduced repair of 8-OH-dG lesions in DNA. GreenMedInfo

PMID:  Occup Environ Med. 2017 Sep ;74(9):680-683. Epub 2017 Jun 26. PMID: 28652381 Abstract Title:  Oxidative DNA damage during night shift work. Abstract:  OBJECTIVES: We previously reported that compared with night sleep, day sleep among shift workers was associated with reduced urinary excretion of 8-hydroxydeoxyguanosine (8-OH-dG), potentially reflecting a reduced ability to repair 8-OH-dG lesions in DNA. We identified the absence of melatonin during day sleep as the likely causative factor. We now investigate whether night work is also associated with reduced urinary excretion of 8-OH-dG.METHODS: For this cross-sectional study, 50 shift workers with the largest negative differences in night work versus night sleep circulating melatonin levels (measured as 6-sulfatoxymelatonin in urine) were selected from among the 223 shift workers included in our previous study. 8-OH-dG concentrations were measured in stored urine samples using high performance liquid chromatography with electrochemical detection. Mixed effects models were used to compare night work versus night sleep 8-OH-dG levels.RESULTS: Circulating melatonin levels during night work (mean=17.1ng/mg creatinine/mg creatinine) were much lower than during night sleep (mean=51.7ng/mg creatinine). In adjusted analyses, average urinary 8-OH-dG levels during the night work period were only 20% of those observed during the night sleep period (95% CI 10% to 30%; p

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09:21

Impairment of learning and memory in mouse offspring induced by perinatal fluoride exposure may partly result from the enhanced miR-124 and miR-132. GreenMedInfo

PMID:  Chemosphere. 2018 Jan 8 ;197:117-122. Epub 2018 Jan 8. PMID: 29334651 Abstract Title:  Effects of perinatal fluoride exposure on the expressions of miR-124 and miR-132 in hippocampus of mouse pups. Abstract:  To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group. Additionally, 100mg/L NaF significantly elevated the expression levels of miR-124, miR-132, and DiGeorge syndrome chromosomal region 8 (DGCR8) in hippocampus of mouse pups at postnatal day (PND) 21. Contrarily, methyl CpG binding protein 2 (MeCP2) were dramatically reduced in 50 and 100mg/L NaF groups, while cAMP-response element binding protein (CREB) mRNA level was significantlydecreased in all fluoride groups. These findings suggested that the impairment of learning and memory in mouse offspring induced by perinatal fluoride exposure may partly result from the enhanced miR-124 and miR-132 and the alterations of their target genes.

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09:06

Rotating shift work was associated with obesity in men from northeastern Ontario. GreenMedInfo

PMID:  Health Promot Chronic Dis Prev Can. 2017 Aug ;37(8):238-247. PMID: 28800293 Abstract Title:  Rotating shift work associated with obesity in men from northeastern Ontario. Abstract:  INTRODUCTION: While some studies have suggested associations between shift work and obesity, few have been population-based or considered multiple shift schedules. Since obesity is linked with several chronic health conditions, understanding which types of shift work influence obesity is important and additional work with more detailed exposure assessment of shift work is warranted.METHODS: Using multivariate polytomous logistic regression, we investigated the associations between shift work (evening/night, rotating and other shift schedules) and overweight and obesity as measured by body mass index cross-sectionally among 1561 men. These men had previously participated as population controls in a prostate cancer case-control study conducted in northeastern Ontario from 1995 to 1999. We obtained information on work history (including shift work), height and weight from the existing self-reported questionnaire data.RESULTS: We observed an association for ever (vs. never) having been employed in rotating shift work for both the overweight (OR [odds ratio] = 1.34; 95% CI [confidence interval]: 1.05-1.73) and obese (OR = 1.57; 95% CI: 1.12-2.21) groups. We also observed nonsignificant associations for ever (vs. never) having been employed in permanent evening/night shifts. In addition, we found a significant trend of increased risk for both overweight and obesity with increasing duration of rotating shift work.CONCLUSION: Both the positive association between rotating shift work and obesity and the suggested positive association for permanent evening/night shift work in this study are consistent with previous findings. Future population-based research that is able to build on our results while examining additional shift work characteristics will further clarify whether some shift patterns have a greater impact on obesity than others.

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08:44

Fluoride depletes acidogenic taxa in oral but not gut microbial communities in mice. GreenMedInfo

PMID:  mSystems. 2017 Jul-Aug;2(4). Epub 2017 Aug 8. PMID: 28808691 Abstract Title:  Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. Abstract:  Fluoridation of drinking water and dental products prevents dental caries primarily by inhibiting energy harvest in oral cariogenic bacteria (such as Streptococcus mutans and Streptococcus sanguinis), thus leading to their depletion. However, the extent to which oral and gut microbial communities are affected by host fluoride exposure has been underexplored. In this study, we modeled human fluoride exposures to municipal water and dental products by treating mice with low or high levels of fluoride over a 12-week period. We then used 16S rRNA gene amplicon and shotgun metagenomic sequencing to assess fluoride's effects on oral and gut microbiome composition and function. In both the low- and high-fluoride groups, several operational taxonomic units (OTUs) belonging to acidogenic bacterial genera (such as Parabacteroides, Bacteroides, and Bilophila) were depleted in the oral community. In addition, fluoride-associated changes in oral community composition resulted in depletion of gene families involved in central carbon metabolism and energy harvest (2-oxoglutarate ferredoxin oxidoreductase, succinate dehydrogenase, and the glyoxylate cycle). In contrast, fluoride treatment did not induce a significant shift in gut microbial community composition or function in our mouse model, possibly due to absorption in the upper gastrointestinal tract. Fluoride-associated perturbations thus appeared to have a selective effect on the composition of the oral but not gut microbial community in mice. Future studies will be necessary to understand possible implications of fluoride exposure for the human microbiome. IMPORTANCE Fluoride has been added to drinking water and dental products since the 1950s. The beneficial effects of fluoride on oral health are due to its ability to inhibit the growth of bacteria that cause dental caries. Despite widespread human consumption of fluoride, there have been only two studies of humans that considered the effect of fluoride on human-associated microbial communities, which are increasingly understood to play important roles in health and disease. Notably, neither of these studies included a true cross-sectional control lacking fluoride exposure, as study subjects continued baseline fluoride treatment in their daily dental hygiene routines. To our knowledge, this work (in mice) is the first controlled study to assess the independent effects of fluoride exposure on the oral and gut microbial communities. Investigating how fluoride interacts with host-associated microbial communities in this controlled setting represents an effort toward understanding how common environmental exposures...

08:42

Senate Votes To Reauthorize NSA Spying Program REALfarmacy.com

Source: Senate Votes To Reauthorize NSA Spying Program For more content like this visit REALfarmacy.com.

While most Congressional observers are focused on the battle to avert a weekend government shutdown (an outcome thats looking increasingly likely), the Senate on Thursday quietly passed an extension of the NSAs spying surveillance program, sending the bill to the presidents desk a week after the House voted to authorize the controversial plan.   Even President []

Source: Senate Votes To Reauthorize NSA Spying Program Learn more at REALfarmacy.com - Healthy News and Information.

08:37

Ancient Sanskrit Reveals the 9 Rules for Being Human Healthy Holistic Living

One of the questions that has puzzled the greatest minds in history is What is the meaning of life?. What is our true purpose on this earth, why are we here? Chances are youll get a different answer from almost every single person. Some people believe that money will help them find the answer, so... View Article

The post Ancient Sanskrit Reveals the 9 Rules for Being Human appeared first on Healthy Holistic Living.

08:15

This study identified increased risks for prostate cancer among men with employment in shift or night work. GreenMedInfo

PMID:  Scand J Work Environ Health. 2017 Nov 1 ;43(6):560-568. Epub 2017 Sep 7. PMID: 28879368 Abstract Title:  Shift work and the incidence of prostate cancer: a 10-year follow-up of a German population-based cohort study. Abstract:  Objectives We investigated the association of shift and night work with the incidence of prostate cancer using data of the population-based prospective Heinz Nixdorf Recall Study from the highly industrialized Ruhr area in Germany. Methods Participants of the baseline survey were recruited between 2000-2003. A follow-up survey including, a detailed interview on shift and night work, was conducted from 2011-2014. We included 1757 men who did not report a history of prostate cancer at baseline. We assessed shift- and night-work exposure up to time of the baseline interview. Incident prostate cancers were recorded from baseline through September 2014. We calculated hazard ratios (HR) of shift- and night-work exposure using Cox proportional hazards regression with age at event as timescale, adjusting for smoking status, family history of prostate cancer, education (13, 14-17, 18 years), and equivalent income (low, medium, high). Results We observed a twofold increased HR for prostate cancer among shift and night workers. Ever employment in shift work was associated with HR 2.29, 95% confidence interval (CI) 1.43-3.67 and night work with HR 2.27, 95% CI 1.42-3.64. HR increased steadily with duration of employment in shift or night work. Stratifying analyses by preferred midpoint of sleep, yielded strongly elevated HR among subjects with early sleep preference, although these analyses were limited by small number of cases. Conclusions We identified increased risks for prostate cancer among men with employment in shift or night work. HR were strongly elevated among long-term employed shift workers and men with early preferred midpoint of sleep.

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07:55

FREE Online Heavy Metals Summit Shows You How to Detox Medical Kidnap

Heavy Metals Summit Register

Health Impact News

You cant escape environmental toxins. No one can. Heavy metals are interfering with your life. Learn how to overcome their influence and reclaim your health!

The Heavy Metals Summit is online and FREE from January 29 February 5, 2018.

Toxins are everywhere. They are in our food, water, air, even our household goodsand theyre destroying health. EVERYONE has some level of mercury toxicity.

Aluminum has been linked to breast cancer, Alzheimers disease, allergies, even autism. The connection between toxins and disease is now undisputed, but its still being ignored by the conventional medical community.

Fortunately, you can protect and heal yourself from these toxic metals!

Why Attend The Heavy Metals Summit Online?

  • Tired of being exhausted, brain fogged, slightly depressed (or worse!)
  • Learn about the toxins lurking in our air, water, food and products
  • Discover why conventional medicine does NOT address heavy metal toxicity
  • Get action steps you can take to detox and heal
  • And so much more!

Every day, we help our patients regain their health through heavy metal detoxification. People with incorrect diagnoses of multiple sclerosis, fibromyalgia or thyroid issues, just to name a few, have found relief through our innovative and individualized protocols to reduce the burden of heavy metals. Were here to help you, too.

Join us at this important event by registering today!

Some of the speakers you will learn from at this event:

Heavy Metals Speakers1Heavy Metals Speakers2...

07:54

FREE Online Heavy Metals Summit Shows You How to Detox Vaccine Impact

Heavy Metals Summit Register

Health Impact News

You cant escape environmental toxins. No one can. Heavy metals are interfering with your life. Learn how to overcome their influence and reclaim your health!

The Heavy Metals Summit is online and FREE from January 29 February 5, 2018.

Toxins are everywhere. They are in our food, water, air, even our household goodsand theyre destroying health. EVERYONE has some level of mercury toxicity.

Aluminum has been linked to breast cancer, Alzheimers disease, allergies, even autism. The connection between toxins and disease is now undisputed, but its still being ignored by the conventional medical community.

Fortunately, you can protect and heal yourself from these toxic metals!

Why Attend The Heavy Metals Summit Online?

  • Tired of being exhausted, brain fogged, slightly depressed (or worse!)
  • Learn about the toxins lurking in our air, water, food and products
  • Discover why conventional medicine does NOT address heavy metal toxicity
  • Get action steps you can take to detox and heal
  • And so much more!

Every day, we help our patients regain their health through heavy metal detoxification. People with incorrect diagnoses of multiple sclerosis, fibromyalgia or thyroid issues, just to name a few, have found relief through our innovative and individualized protocols to reduce the burden of heavy metals. Were here to help you, too.

Join us at this important event by registering today!

Some of the speakers you will learn from at this event:

Heavy Metals Speakers1Heavy Metals Speakers2...

07:52

Integrated evidence from this meta-analysis suggests that shift work is significantly associated with an increased risk of prostate cancer. GreenMedInfo

PMID:  Carcinogenesis. 2017 Nov 8. Epub 2017 Nov 8. PMID: 29126152 Abstract Title:  Association between shift work and risk of prostate cancer: a systematic review and meta-analysis of observational studies. Abstract:  Observational studies suggest that shift work may be associated with prostate cancer. However, the results are inconsistent. The objective of this study is to quantitatively assess the association between shift work and the risk of prostate cancer. Relevant studies were identified by a comprehensive search of the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases to September 2017. We also reviewed the reference lists from retrieved articles. Observational studies that reported relative risk (RR) with 95% confidence intervals (CIs) for the association between shift work and the risk of prostate cancer were included. A linear and nonlinear dose-response meta-analysis was performed. Fifteen studies with 16 independent reports involving 2,546,822 individuals and 10,715 patients with prostate cancer were included. The pooled adjusted RR for the association between ever exposure to shift work and prostate cancer risk was 1.23 (95% CI, 1.08-1.41; P

read more

07:39

FREE Online Heavy Metals Summit Shows You How to Detox Health Impact News

Heavy Metals Summit Register

Health Impact News

You cant escape environmental toxins. No one can. Heavy metals are interfering with your life. Learn how to overcome their influence and reclaim your health!

The Heavy Metals Summit is online and FREE from January 29 February 5, 2018.

Toxins are everywhere. They are in our food, water, air, even our household goodsand theyre destroying health. EVERYONE has some level of mercury toxicity.

Aluminum has been linked to breast cancer, Alzheimers disease, allergies, even autism. The connection between toxins and disease is now undisputed, but its still being ignored by the conventional medical community.

Fortunately, you can protect and heal yourself from these toxic metals!

Why Attend The Heavy Metals Summit Online?

  • Tired of being exhausted, brain fogged, slightly depressed (or worse!)
  • Learn about the toxins lurking in our air, water, food and products
  • Discover why conventional medicine does NOT address heavy metal toxicity
  • Get action steps you can take to detox and heal
  • And so much more!

Every day, we help our patients regain their health through heavy metal detoxification. People with incorrect diagnoses of multiple sclerosis, fibromyalgia or thyroid issues, just to name a few, have found relief through our innovative and individualized protocols to reduce the burden of heavy metals. Were here to help you, too.

Join us at this important event by registering today!

Some of the speakers you will learn from at this event:

Heavy Metals Speakers1Heavy Metals Speakers2...

07:24

What Medical Marijuana Patients and Providers Need to Know About a Government Shutdown REALfarmacy.com

Source: What Medical Marijuana Patients and Providers Need to Know About a Government Shutdown For more content like this visit REALfarmacy.com.

If the US federal government shuts down at midnight on Friday, medical marijuana patients and providers will suddenly be at risk of being arrested, prosecuted, and sent to prison by Jeff Sessions Justice Department. Heres why: An existing budget provision, the Rohrabacher-Blumenauer amendment prevents the Drug Enforcement Administration (DEA) and other agencies from spending money to []

Source: What Medical Marijuana Patients and Providers Need to Know About a Government Shutdown Learn more at REALfarmacy.com - Healthy News and Information.

07:23

Youre Only As Happy As Your Least Happy Child Healthy Holistic Living

If youre a parent, you know that the moment you have a child your whole life changes. Your life revolves around protecting and loving this tiny little person and you follow them every step of the way. Every high and low, you are there to congratulate them or pick them up and dust them off.... View Article

The post Youre Only As Happy As Your Least Happy Child appeared first on Healthy Holistic Living.

07:21

What does the way you sit reveal about your personality? Healthy Holistic Living

Body language is a strong form of communication. More specifically, your sitting position can say a lot about your personality. Take a look at these different sitting positions and find out if the way you sit describes you perfectly. Position A People who sit in this position are quirky and unique. They have their own... View Article

The post What does the way you sit reveal about your personality? appeared first on Healthy Holistic Living.

07:20

6 Best Core Exercises You Can Do at Home Without Equipment Healthy Holistic Living

Over time, age can take quite a toll on strength and mobility. Without proper upkeep and maintenance, your body will grow weaker and more immobile, as will the risk of falls, fractures, breaks, and other injuries.[1] Think of your core muscles as a tree trunk, where your lower body is the roots and your upper... View Article

The post 6 Best Core Exercises You Can Do at Home Without Equipment appeared first on Healthy Holistic Living.

07:20

WARNING! Flu Drug Tamiflu Has Dangerous Side Effects NOT Being Communicated to the Public Health Impact News

Tamiflu-family-warning

Image from video at CBS DFW.

by Brian Shilhavy
Editor, Health Impact News

As the U.S. is in the midst of one of the worst outbreaks of influenza in years, frightening reports are coming in regarding an FDA-approved drug being given to allegedly lessen the effects of the flu: Tamiflu.

Local CBS news affiliate DFW in Dallas, Texas, has reported the story of a 6 year old girl who was given Tamiflu and suffered horrible hallucinations, allegedly trying to kill herself:

A North Texas family says their daughters side effects from the popular drug Tamiflu were beyond what they ever could have imagined and left them saying never again.

Like so many others, the 6-year-olds flu diagnosis came with a choice: whether or not to take Tamiflu to speed up the course of the dreaded illness.

The family from Allen, who wants to remain anonymous, says the side effects were stunning: hallucinations, running away from school and an attempt, they believe, to hurt herself.

The second story window was open, which is in her bedroom, and she used her desk to climb up onto it, and she was about to jump out the window when my wife came up and grabbed her, her father said.

It is written in the fine print . theres always a chance of a side effect with any drug. The little girls parents say they wish they had known.

I dont think the 16 hours of symptom relief from the flu is worth the possible side effects that we went through, her father said.

As is usual with most corporate mainstream media stories regarding anything negative about a pharmaceutical product, the report included testimony from a doctor assuring the public that such side effects are very rare, and that the drug is very safe.

But is it?

Here are some comments from the article that were posted:

My nieces 53 year old husband took one dose of Tamiflu and died suddenly from respiratory failure. Sally Baumann Rogers

My husband suffered from hallucinations attributed to Tamiflu last year after he was hospitalized for flu with pneumonia (despite getting a flu shot). He had b...

07:19

True Roots of Narcissism Healthy Holistic Living

Self-absorbed, vain, egotistical, and conceitedthere are just some of the words one might use to describe a narcissist. And rightly so, people with narcissistic traits exude this kind of behavior to everyone around them and sometimes you wonder how one could be so self-involved. Is it genetics? Is it their environment? Is it a mask... View Article

The post True Roots of Narcissism appeared first on Healthy Holistic Living.

07:17

Night shift work increases the risks of multiple primary cancers in women. GreenMedInfo

PMID:  Cancer Epidemiol Biomarkers Prev. 2018 Jan ;27(1):25-40. PMID: 29311165 Abstract Title:  Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles. Abstract:  A growing number of studies have examined associations between night shift work and the risks of common cancers among women, with varying conclusions. We did a meta-analysis to identify whether long-term night shift work increased the risks of common cancers in women. We enrolled 61 articles involving 114,628 cases and 3,909,152 participants from Europe, North America, Asia, and Australia. Risk estimates were performed with a random-effect model or a fixed-effect model. Subgroup analyses and meta-regression analyses about breast cancer were conducted to explore possible sources of heterogeneity. In addition, we carried out a dose-response analysis to quantitatively estimate the accumulative effect of night shift work on the risk of breast cancer. A positive relationship was revealed between long-term night shift work and the risks of breast [OR = 1.316; 95% confidence interval (CI), 1.196-1.448], digestive system (OR = 1.177; 95% CI, 1.065-1.301), and skin cancer (OR = 1.408; 95% CI, 1.024-1.934). For every 5 years of night shift work, the risk of breast cancer in women was increased by 3.3% (OR = 1.033; 95% CI, 1.012-1.056). Concerning the group of nurses, long-term night shift work presented potential carcinogenic effect in breast cancer (OR = 1.577; 95% CI, 1.235-2.014), digestive system cancer (OR = 1.350; 95% CI, 1.030-1.770), and lung cancer (OR = 1.280; 95% CI, 1.070-1.531). This systematic review confirmed the positive association between night shift work and the risks of several common cancers in women. We identified that cancer risk of women increased with accumulating years of night shift work, which might help establish and implement effective measures to protect female night shifters. Cancer Epidemiol Biomarkers Prev; 27(1); 25-40.2018 AACR.

read more

07:09

The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission Fluoride Action Network

In conclusion, the effects of NaF on a cells survival and integrity
suggested that different concentrations NaF had direct toxic effects
on the Neuro-2A cell line. NaF not only reduced the expression of
select axonal proteins, but also prevented the secretion and delivery
of the neurotransmitter glutamate.We found that expression
of glutamate and its receptor, NMDAR, decreased with increasing
dosages of NaF. Presumably, NaF can influence the generation and
functions of axons, and limit the secretion and transmission of
neurotransmitters. Considering that the affected neurons are unable
to send signals to others, it is possible that excessive fluoride
exposure may play a role in the pathogenesis of mental disabilities
and other neurodegenerative diseases. However, while this study
reports the toxic effects of NaF in Neuro-2A, further studies are
required to determine the specific mechanisms involved.

06:55

WARNING! Flu Drug Tamiflu Has Dangerous Side Effects NOT Being Communicated to the Public Vaccine Impact

Tamiflu-family-warning

Image from video at CBS DFW.

by Brian Shilhavy
Editor, Health Impact News

As the U.S. is in the midst of one of the worst outbreaks of influenza in years, frightening reports are coming in regarding an FDA-approved drug being given to allegedly lessen the effects of the flu: Tamiflu.

Local CBS news affiliate DFW in Dallas, Texas, has reported the story of a 6 year old girl who was given Tamiflu and suffered horrible hallucinations, allegedly trying to kill herself:

A North Texas family says their daughters side effects from the popular drug Tamiflu were beyond what they ever could have imagined and left them saying never again.

Like so many others, the 6-year-olds flu diagnosis came with a choice: whether or not to take Tamiflu to speed up the course of the dreaded illness.

The family from Allen, who wants to remain anonymous, says the side effects were stunning: hallucinations, running away from school and an attempt, they believe, to hurt herself.

The second story window was open, which is in her bedroom, and she used her desk to climb up onto it, and she was about to jump out the window when my wife came up and grabbed her, her father said.

It is written in the fine print . theres always a chance of a side effect with any drug. The little girls parents say they wish they had known.

I dont think the 16 hours of symptom relief from the flu is worth the possible side effects that we went through, her father said.

As is usual with most corporate mainstream media stories regarding anything negative about a pharmaceutical product, the report included testimony from a doctor assuring the public that such side effects are very rare, and that the drug is very safe.

But is it?

Here are some comments from the article that were posted:

My nieces 53 year old husband took one dose of Tamiflu and died suddenly from respiratory failure.  Sally Baumann Rogers

My husband suffered from hallucinations attributed to Tamiflu last year after he was hospitalized for flu with pneumonia (despite getting a flu shot). He had been...

06:51

Gardasil effectiveness yes, HPV vaccine does protect you against cancer Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Although I have no poll numbers sitting in front of me, and certainly no scientific peer-reviewed research, I just have a feeling that if you scratch the surface of an anti-vaccine activist, you will find that if they could hate one vaccine, it would be Gardasil. And one of the arguments will be all about

Skeptical Raptor

06:49

All in the Family: 4 Steps Toward Healing Adverse Childhood Experiences Mad In America

At the end of my TED Talk one of the conferences co-hosts came onto the stage and asked me, with a respectful interest, whether I still hear voices. For a split second I hesitated, wondering whether to play it down with an airy oh, not all that much now. Instead I opted for the truth: All the time, I said cheerfully, In fact I heard them while I did the talk they were reminding me what to say!

06:44

Top 22 Uses for Apple Cider Vinegar Natural Blaze

apple cider vinegar benefits

By Dr. Mercola

Hippocrates used vinegar to manage wounds, while medical practitioners in the 1700s used it to treat everything from poison ivy and croup to stomach aches. Vinegar was even used to treat diabetes.1

Vinegar, which means sour wine in French, can be made from virtually any carbohydrate that can be fermented, including grapesdatescoconutpotatoesbeets, and, of course, apples.

The benefits and uses of apple cider vinegar (ACV) are now known to many (more on this later), which is why this is becoming a staple in many peoples kitchen pantries.

Traditionally, vinegar is made through a long, slow fermentation process, leaving it rich in bioactive components like acetic acid, gallic acid, catechin, epicatechin, caffeic acid, and more, giving it potent antioxidant, antimicrobial, and many other beneficial properties.

As reported in Medscape General Medicine:2

The slow methods are generally used for the production of the traditio...

06:30

Deadly Flu? Tents Outside Hospitals? Missing IV Fluid! Relax, Its a Long Planned Psyop Natural Blaze

Are you seeing news coverage of people pitching tents outside hospitals having come down with a deadly and there is a shortage of IV bags.  If this doesnt sound staged, its hard to imagine what would.

For the deadly part, people should look up Sharyl Atkisson  because she reported on the terrifying swine flu in 2009 and found that in some cases, the CDCs reporting was off by as much as 98%.  In most cases, there was no flu at all.

Jon Rappaport covered her reporting because it was so good.  Hed be a good person for various sites to interview because were back to deadly  and fake, fake, fake for as much fear as possible.
If we realize that those behind the vaccines have millions loaded with microchips and without a big push of some kind, they arent going to get 100% coverage.
 

What Sharyl Attkisson told me about vaccines Jon Rappoport

We discovered through our FOI efforts that before the CDC mysteriously stopped counting Swine Flu cases, they had learned that almost none of the ca...

06:29

Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity. Fluoride Action Network

from 4. Discussion

In order to gain a better understanding of the NaF neurotoxicity and its underlying mechanisms, the NaF-treated rats and SH-SY5Y cells were used in the present study. The MWM [Morris water maze test] results showed that exposure of rats to NaF is associated with decreased learning and memory abilities. This is consistent with previous studies where animals exposed to fluoride with similar dosages and duration can also demonstrated different characteristics of neurotoxicity, such as neurochemical alterations, neurodegeneration, open-field habituation abnormity, neurotransmitters change, and memory impairment (Jiang et al., 2014b; Liu et al., 2010).

The present results also revealed that exposure of rats to NaF resulted in evident neuron damage, as manifested by histopathological abnormalities in NaF-treated rat hippocampus, such as obviously decreased Nissl bodies, which closely related to protein synthesis capabilities. In addition, the results also demonstrated that NaF exposure caused multiple ultrastructure alterations in hippocampal CA3 region. Jiang et al. (2014a) reported that condensed, interstitial and degenerated neurons were observed in fluoride-treated hippocampal CA1 regions of developmental rat.

The present results are in agreement with Jiangs study, and extended by the observation of ultrastructure alterations of ER and mitochondria, implying ER and mitochondria impairment following NaF exposure. These results, together with the cognitive deficits of rats, suggest that NaF exposure induces not only the behavioral changes, but also the morphological and functional impairments

5. Conclusions
Taken together, our results present in vitro and in vivo evidence showing that exposure to the environmental toxicant fluoride results in excessive ER stress, and autophagic flux dysfunction. In particular, it is the first time, to our knowledge, to demonstrate a molecular link between ER stress-mediated autophagic flux dysfunction and fluoride-induced neurotoxicity, which provides novel insight into a better understanding of mechanisms and prevention for fluoride neurotoxicity.

06:05

Judge orders journal to identify peer reviewers: CrossFit lawyer Retraction Watch

A court is reportedly telling a journal to unmask a retracted papers peer reviewers, part of a defamation lawsuit involving the journals publisher and the CrossFit exercise brand. According to an attorney representing CrossFit, yesterday Judge Joel Wohlfeil of the San Diego Superior Court decided that the National Strength and Conditioning Association (NSCA) must turn []

The post Judge orders journal to identify peer reviewers: CrossFit lawyer appeared first on Retraction Watch.

05:55

Rotating shift work and day-oriented shift work increased the risk of developing anticitrullinated peptide antibodies-positive rheumatoid arthritis. GreenMedInfo

n/a PMID:  RMD Open. 2017 ;3(2):e000475. Epub 2017 Aug 29. PMID: 29225920 Abstract Title:  Relationship between shift work and the onset of rheumatoid arthritis. Abstract:  Background: Environmental factors play a prominent role in rheumatoid arthritis (RA) aetiology. Shift work has previously been associated with increased RA risk in females. The aim of this study was to investigate the potential association, including a dose-response association, between permanent night shift work, rotating shift work and day-oriented shift work and risk of developing anticitrullinated peptide antibodies (ACPA)-positive and ACPA-negative RA. Methods: The present report is based on a population-based, case-control study with incident cases of RA (1951 cases and 2225 controls matched by age, gender and residential area). Using logistic regression, occurrence of RA among subjects who have been exposed to different kinds of shift work was compared with that among those who have never been exposed by calculating the OR with a 95% CI. Results: Rotating shift work and day-oriented shift work increased the risk of developing ACPA-positive RA (OR 1.3, 95%CI 1.0 to 1.7 and OR 1.3, 95%CI 1.0 to 1.6), but not ACPA-negative RA. Permanent night shift work appeared to be a protective factor both against ACPA-positive RA (OR 0.7, 95%CI 0.6 to 0.9) and ACPA-negative RA (OR 0.8, 95%CI 0.6 to 1.0). For both subsets of RA, significant trends showeda lower risk of developing RA with increasing duration of permanent night shift work (p value for trend 0.002 vs 0.04). Conclusions: Sleep restriction as a consequence of shift work is associated with several biological effects among which changes in melatonin production may be involved. The present epidemiological findings of a complex relationship between sleep patterns and different forms of RA may be of importance for increasing the understanding of the pathophysiology of RA.

05:32

Melatonin combined with or without exercise prevented periarticular muscle damage as well as cartilage degeneration. GreenMedInfo

PMID:  Oncotarget. 2017 Nov 14 ;8(57):97633-97647. Epub 2017 Jul 16. PMID: 29228639 Abstract Title:  Role of melatonin combined with exercise as a switch-like regulator for circadian behavior in advanced osteoarthritic knee. Abstract:  Here, we show the role of melatonin combined with or without exercise as a determinant of multicellular behavior in osteoarthritis. We address the relationship between the molecular components governing local circadian clock and changes in the osteoarthritic musculoskeletal axis. Melatonin was injected subcutaneously in animals with advanced knee osteoarthritis (OA) for 4 weeks. Concurrently, moderate treadmill exercise was applied for 30 min/day. Morphometric, histological, and gene/protein-level analyses were performed in the cartilage, synovium, bone, and gastrocnemius muscle. Primary cultured chondrocytes repeatedly exposed to TNF- were used in an in vitro study. The symptoms of OA include gait disturbance, osteophyte formation, and abnormal metabolism of the extracellular matrix (ECM) of the cartilage. Low-level expression of clock genes was accompanied by aberrant changes in cartilage specimens. Nanomolar doses of melatonin restored the expression of clock-controlled genes and corrected the abnormal chondrocyte phenotype. Melatonin combined with or without exercise prevented periarticular muscle damage as well as cartilage degeneration. But prolonged melatonin administration promoted the proteolytic cleavage of RANKL protein in the synovium, leading to severe subchondral bone erosion. These musculoskeletal changes apparently occurred via the regulation of molecular clock components, suggesting a role of melatonin as a switch-like regulator for the OA phenotype.

read more

05:19

Trumps D-ficiency Exposes Major Health Threat This Flu Season The Alliance for Natural Health

And its not just the president thats in danger. Action Alert!

Recently the White House doctor gave a report following his first physical exam of the president. The results of this physical exam are telling: being one of the most powerful men in the world does not necessarily mean you get better healthcare.

The White House physician, Dr. Ronny Jackson, emphasized how healthy President Trump is, but the results show that his vitamin D was 20 ng/ml, which is at the absolute bottom of the safe reference range of 20-100.  This is the Institute of Medicines recommendation, but integrative doctors and natural health experts recommend much higher minimum levels than 20. Dr. Joseph Mercola, for instance, says that 50-70 ng/ml is optimal, and anything less than 50 is deficient. Some believe that a minimum of 70 will eliminate most viral illness and also be highly protective against cancer.

No one recommends a level higher than 100, which may trigger hyper-calcemia (too much calcium in the blood), but even that risk may be reduced by taking vitamin K-2. ANH-USA has, for quite some time, called for the government to educate the public about the importance of maintaining the correct vitamin D levels, considering that at least one third of Americans are vitamin D deficient.

In addition to regulating the absorption of nutrients and helping us build bone, vitamin D facilitates normal immune system function and can help reduce the risk of respiratory infections and the flu. Part of the reason for vitamin Ds effectiveness is that it doesnt depend on guessing which strain of influenza to create a vaccine against, as health officials do before each flu season. Vitamin D could be saving lives and keeping people healthy.  Yet the Centers for Disease Control (CDC) is still only telling the public about the ineffective flu shot, notwithstanding reports that this years flu vaccine is roughly 30% effective in one of the worst flu seasons in recent history.

During his phy...

04:45

Life Sentence: Life Behind the Bars of the Mental Health System Mad In America

My name is Sandra. I aspire to hopes and dreams just like everybody else. Im a hardworking woman, taking great pride in my manual labor jobs that keep me physically fit. Because of my love for the great outdoors, my dream is to eventually work in the Parks and Recreation Department in some capacity. I highly value my integrity, honesty and creativity. I am friendly, social and active. Im fun-loving, inheriting my fathers dry sense of humor, sense of adventure and gift of gab. I inherited my mothers love of nature, independence and self-sufficiency. I strive to fulfill my American Dream: cherishing my children beyond words, looking forward to my life with them, them with me, settling down with a husband somewhere in a small country home with a few horses, flower beds, a vegetable garden and cats galore. I do not expect nor want anything fancy. My goal is to live a very simple life. Im ambitious, goal driven and highly motivated, making sure I accomplish my dreams.

But, that was my previous life.

That was before my dreams were shattered by psychiatric labels and drugs. The mental health system displaced me from my normal life, forcing me to live on the other side of the tracks, pushing me to the fringes of society.

Over thirty-five years ago, at the age of 22, my local community mental healthcare system gave me a life sentence. By then, Id been living with PTSD for years following two violent rapes. The first rape was at knifepoint when I was 13 years old, the other at 19 when I was kidnapped and taken to a cemetery for the night by two unknown men. Both experiences were terrifying. I was also trying to adjust to living with my new abusive, alcoholic husband that I did love. So, I sought out the guidance of a psychiatrist, in whom I put my utmost trust. Instead of the help I anticipated, the psychiatrist labeled me with bipolar disorder, telling me that I had a chemical imbalance in my brain. I quickly found out that the minute you sit down in the chair in a mental health professionals office, youre no longer seen as a person. The mental health system is incapable of seeing past the solid wall of your current label. Their only cure is drugs.

Little did I know that the drugs I was prescribed during that visit would change the entire course of my life. Due to the severe side effects, adverse effects and continuous withdrawal symptoms I experienced from at least 60 different medications and rounds of ECT doctors used to treat the diseased mind they said I had, for decades, my entire life was stuck in the revolving door of psychiatric hospitals, intensive care units, police stations, jails, burn units, alcohol treatment centers and AA meetings. My twin sister was the only relative that ever helped me. She often flew to Michigan from Florida to help me care for my five-acre property after I became too disabled to do it myself, when I...

03:49

Unhealthiest State Has the Best Vaccination Rate: Offits Orwellian Logic Fails Natural Blaze

By  the World Mercury Project Team

The Unhealthiest State in America Has the Best Vaccination Rate: Offits Orwellian Logic Fails to Connect the Dots

In a Daily Beast opinion piece on December 15, Paul Offitone of the vaccine industrys most strident ambassadorspuzzles over a seeming contradiction. How, Offit wonders, could the state of Mississippi, which has the worst overall health in the nation, have used standout efficiency to achieve over 99.4% vaccine coverage in kindergartners? Rather than seriously investigate this apparent enigma, Offit presents his ready-made answer and reveals his articles true purpose. According to Paul Offit, Mississippis high vaccination rates are due to the states 1979 decision to make the governmentrather than parentsthe primary vaccine decision-maker for children.

Reflecting on the Mississippi Supreme Courts 1979 elimination of that states religious exemption to vaccination, Offit applauds the Courts position, stating, If a parent harbors a religious belief that contradicts a basic tenant [sic] of modern medicinethe state has a right to protect the child from the irresponsible acts of the parent. Offitthough a parent himselftells readers that the state-determined duty to vaccinate supersedes other parental rights. In short, Offit appears to believe that coercion is the name of the game, openly admitting that he disapproves of the 47 states that still allow parents in the U.S. to take religious, moral or personal beliefs into account when making vaccine decisions on behalf of their children.

 

...

03:30

FDA: All Homeopathic Drugs Illegal Natural Blaze

homeopathic drugs

BY 

But not all will be pulled from the market, yet. Action Alert!

The policy comes in the form of a guidance document, which lays out the FDAs current position on the regulation of homeopathic drugs.

SEE: FDA Sets Sight On Homeopathy, Part Of Larger Big Pharma Jihad

In the guidance, the FDA says:

  1. Any homeopathic drug that has not been considered generally recognized as safe and effective (GRAS/E) is considered a new drug;
  2. FDA has not determined that any homeopathic drugs are GRAS/E;
  3. A new drug cannot be marketed unless it goes through the FDAs approval process;
  4. No homeopathic drugs have gone through FDA approval nor can any producer afford to take them through the approval process.

Thats right: in one fell swoop, the FDA has declared that virtually every single homeopathic drug on the market is being sold illegally. The guidance explains that the agency will apply a risk-based regulatory approach that will prioritize enforcement actions against:

  • products with reported sa...

03:16

Govt Revokes Off-Grid Amish Communitys Religious Rights, Forces Them to Use Electricity Natural Blaze

 amish off grid

In spite of the fact that they have harmed no one, a court is forcing an Amish family to violate their religious beliefs and use electricity.

An Amish community in Warren County has just lost a major battle against the state which is now requiring them to violate their religious beliefs and use electricity. Despite the Yoder family never causing harm to anyone by not using electricity, the government is forcing them to connect to the grid anyway.

At the heart of the Amish religion is the rejection of individualism. The Amish anti-individualist orientation is the motive for rejecting labor-saving technologies that might make one less dependent on their community. Modern innovations like electricity might spark a competition for status goods which is in direct conflict with the Amish way of life. Therefore, they reject it.

While the Amish lifestyle may seem odd to others, the fact that it causes no harm should mean that no one should be able to force them to change. Sadly, that is not the case.

The Yoder family lives entirely off-grid. This off-grid religious lifestyle includes the use of a self-composting toiletan old-fashioned privythat did not require electricity or running water.

Had the Yoder family been dumping their raw sewage int...

00:33

NZ Health Officials Proven Wrong on Mercury Amalgam Fillings Fluoride Action Network

They are Wrong about Fluoride too!

Finally, NZ health officials are moving to stop mercury amalgam fillings. The Waikato DHB announced today that it was no longer going to use mercury amalgam fillings after the European Union announced it was banning amalgam fillings for children.

But instead of admitting that these fillings will have caused health problems for many, probably hundreds of thousands, of New Zealanders, Waikato DHB dentist Rob Aitken said publicly that amalgam fillings are dangerous to the environment and it is not prudent to use in pregnant women.

Why has it taken so long even to admit this? Germany, Austria, Sweden and Denmark were phasing out the use of mercury amalgam fillings in the mid-1990s. If it is dangerous to the environment, then obviously it is dangerous to put into our mouths where mercury vapour is released upon chewing. And as, Dr Aitken pointed out, crematoria release a lot of mercury into the air. That has always been known, but ignored.

Tauranga doctor, Mike Godfrey has warned every Health Minister about this since 1980s. He also confirms that In 1996, following my concerns about mercury and senile dementia, Prime Minister Shipley invited me to co-author a Govt. White Paper Dental Amalgam and Human Health. I included in my contribution the just-released Canadian Health Department findings on mercury vapour from amalgam, specifically, no more than 4 fillings in a 70kg adult; no more than 1 in a small child; no amalgam in pregnant or breast-feeding women; no amalgam in anyone with kidney disease; and no amalgam with other metals in the mouth. This advice was circulated to all dental personnel the following year but apparently is still ignored. Notably, as I documented in 2003 in the Journal of Alzheimers Disease, we are heading for an epidemic of senile dementia due to the practice of filling the valleys by the school dental nurses during the 50-70 decades.

Todays 40 to 70 year olds have often had twice as many, and sometimes even four times, the Canadian-identified maximum limit of four mercury fillings. How many people are having their lives shortened and how much is it costing the taxpayer in dementia care, all because these people would not err on the side of safety?

Instead of being given the respect he deserved, Dr Godfrey was labelled a quack by the indoctrinated NZ Skeptics Society. Yet to this day the NZ Government warns people not to eat too much fish, (especially p...

00:11

Indexing company praises cancer journal, then kicks it out Retraction Watch

A company that indexes journals which, in turn, designates their impact factors has delisted Oncotarget, a cancer journal that was recently removed from MEDLINE. Just three months ago, on October 18, the indexing company Clarivate Analytics (formerly part of Thomson Reuters) named Oncotarget a rising star in the field of molecular biology and genetics. []

The post Indexing company praises cancer journal, then kicks it out appeared first on Retraction Watch.

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Friday, 19 January

23:54

Why Senator Dick Durbin INTENTIONALLY Torpedoed the DACA Discussions BolenReport

by Elissa Meininger Health Policy Analyst Hey, folks.  Here we go again getting dragged through another news media knothole forced to endure endless diatribes about how President Trump is unfit for public office. Last weeks topic was how he was mentally unstable and needed to be impeached ASAP before he blew up the world. Continue reading Why Senator Dick Durbin INTENTIONALLY Torpedoed the DACA Discussions

The post Why Senator Dick Durbin INTENTIONALLY Torpedoed the DACA Discussions appeared first on BolenReport.

22:49

How Belief In Our Limited Supply Affects Our Willpower PreventDisease.com

Americans believe they have less stamina for strenuous mental activity than their European counterparts -- an indication that people in the U.S. perceive their willpower or self-control as being in limited supply, a new study suggests.

22:03

The Psychology of Inequality Mad In America

From The New Yorker: A number of studies show that much of the damage done by being poor comes not from the conditions of poverty itself, but from the psychological effects of inequality and low socioeconomic status in comparison to others.

Payne is now a professor at the University of North Carolina, Chapel Hill. He has come to believe that whats really damaging about being poor, at least in a country like the United Stateswhere, as he notes, even most people living below the poverty line possess TVs, microwaves, and cell phonesis the subjective experience of feeling poor. This feeling is not limited to those in the bottom quintile; in a world where people measure themselves against their neighbors, its possible to earn good money and still feel deprived. Unlike the rigid columns of numbers that make up a bank ledger, status is always a moving target, because it is defined by ongoing comparisons to others, Payne writes.

Article

22:02

Video: Alain Badiou and Michel Foucault Mad In America

From Verso: A televised 1965 discussion between Alain Badiou and Michel Foucault, under the heading Philosophy and Psychology, is available to stream in three parts.

Videos 

22:01

The Autism Paradox Mad In America

In this piece for Aeon, Bonnie Evans chronicles the history of the diagnosis of autism, from its establishment as a marker of dysfunction and impairment to the contemporary neurodiversity movement, which frames autism as a difference rather than a disorder. She then poses the concern that the notion of autism as difference, not disorder, may be used to justify neoliberal cuts to resources and accommodations for autistic people, exploring the question, Can we identify and classify aspects of psychology without stigmatizing and limiting them?

Is there really an autism paradox? Or is this actually a paradox of human difference, and of what it means to delineate human types while also offering people the best opportunity to thrive. If we are to think creatively about how to identify difference without stigmatising it, it pays to think historically about how autism research got us to this point. Such history offers a rather humbling lesson: that it might very well be impossible to measure, classify and quantify an aspect of human psychology, without also muting attempts to tell the story differently.

22:00

The Advisory Committee On Childhood Vaccines Votes NO To Tics As Vaccine Injury AGE OF AUTISM

By Teresa Conrick Advisory Committee on Childhood Vaccines Votes No to Tics as Vaccine Injury Tics used to be associated with a sole diagnosis of Tourette Syndrome. Today, they are more frequently seen in Autism Spectrum Disorder, PANDAS, and PANS...

19:00

Legislative Alchemy 2017: Acupuncture Science-Based Medicine

Acupuncture is nothing more than a theatrical placebo. Yet acupuncturists, defined as primary care practitioners in some states, are succeeding in licensing and practice expansion efforts in state legislatures.

16:52

Jan 19, Gallstone Diet - Best Diet For Gallstone Sufferers | ABDOPAIN.com The Abdominal Pain BlogKeeping You Updated On What Is New On The Site!

A gallstone diet can help prevent or reduce the presence of gall stones and avoid gall bladder surgery. Here are the best diets for gallstone sufferers and

12:19

Melatonin promotes brain-derived neurotrophic factor expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia. GreenMedInfo

PMID:  Med Sci Monit. 2017 Dec 16 ;23:5951-5959. Epub 2017 Dec 16. PMID: 29247156 Abstract Title:  Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Abstract:  BACKGROUND Melatonin therapy shows positive effects on neuroprotective factor brain-derived neurotrophic factor (BDNF) expression and neuronal apoptosis in neonatal hemolytic hyperbilirubinemia. We hypothesized that melatonin promotes BDNF expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia through a phospholipase (PLC)-mediated mechanism. MATERIAL AND METHODS A phenylhydrazine hydrochloride (PHZ)-induced neonatal hemolytic hyperbilirubinemia model was constructed in neonatal rats. Four experimental groups - a control group (n=30), a PHZ group (n=30), a PHZ + melatonin group (n=30), and a PHZ + melatonin+U73122 (a PLC inhibitor) group (n=30) - were constructed. Trunk blood was assayed for serum hemoglobin, hematocrit, total and direct bilirubin, BDNF, S100B, and tau protein levels. Brain tissue levels of neuronal apoptosis, BDNF expression, PLC activity, IP3 content, phospho- and total Ca2+/calmodulin-dependent protein kinase type IV (CaMKIV) expression, and phospho- and total cAMP response element binding protein (CREB) expression were also assayed. RESULTS PHZ-induced hemolytic hyperbilirubinemia was validated by significantly decreased serum hemoglobin and hematocrit as well as significantly increased total and direct serum bilirubin (p

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11:57

Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers. GreenMedInfo

PMID:  J Pineal Res. 2017 Dec 16. Epub 2017 Dec 16. PMID: 29247557 Abstract Title:  Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. Abstract:  Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of treatment with the mTOR inhibitor rapamycin is often limited by chemoresistance. Melatonin suppresses neoplastic growth via different mechanisms in a variety of tumours. In this study, we aimed to elucidate the effects of melatonin on rapamycin-induced HNSCC cell death and to identify potential cross-talk pathways. We analysed the dose-dependent effects of melatonin in rapamycin-treated HNSCC cell lines (Cal-27 and SCC-9). These cells were treated with 0.1, 0.5 or 1 mmol/L melatonin combined with 20 nM rapamycin. We further examined the potential synergistic effects of melatonin with rapamycin in Cal-27 xenograft mice. Relationships between inhibition of the mTOR pathway, reactive oxygen species (ROS), and apoptosis and mitophagy reportedly increased the cytotoxic effects of rapamycin in HNSCC. Our results demonstrated that combined treatment with rapamycin and melatonin blocked the negative feedback loop from the specific downstream effector of mTOR activation S6K1 to Akt signalling, which decreased cell viability, proliferation and clonogenic capacity. Interestingly, combined treatment with rapamycin and melatonin-induced changes in mitochondrial function, which were associated with increased ROS production, increasing apoptosis and mitophagy. This led to increase cell death and cellular differentiation. Our data further indicated that melatoninadministration reduced rapamycin-associated toxicity to healthy cells. Overall, our findings suggested that melatonin could be used as an adjuvant agent with rapamycin, improving effectiveness while minimizing its side effects.

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11:30

Gardasil prevents cancer evidence for oral cancer protection Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

According to recent studies from the CDC, only about 63% of teen girls and 50% of teen boys have started the HPV vaccination series. The relatively low vaccine uptake, despite the evidence that Gardasil prevents cancer, one of the few ways to actually prevent cancer, is especially frustrating to those of us who are supporters

Skeptical Raptor

11:25

Melatonin partially protects 661W cells from H2O2-induced death. GreenMedInfo

PMID:  Mol Vis. 2017 ;23:844-852. Epub 2017 Dec 3. PMID: 29259391 Abstract Title:  Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3. Abstract:  Purpose: Previous studies have shown that melatonin (MEL) signaling is involved in the modulation of photoreceptor viability during aging. Recent work by our laboratory suggested that MEL may protect cones by modulating the Fas/FasL-caspase-3 pathway. In this study, we first investigated the presence of MEL receptors (MT1 and MT2) in 661W cells, then whether MEL can prevent H2O2-induced cell death, and last, through which pathway MEL confers protection.Methods: The mRNA and proteins of the MEL receptors were detected with quantitative PCR (q-PCR) and immunocytochemistry, respectively. To test the protective effect of MEL, 661W cells were treated with H2O2 for 2 h in the presence or absence of MEL, a MEL agonist, and an antagonist. To study the pathways involved in H2O2-mediated cell death, a Fas/FasL antagonist was used before the exposure to H2O2. Finally, Fas/FasL and caspase-3 mRNA was analyzed with q-PCR and immunocytochemistry in cells treated with H2O2 and/or MEL. Cell viability was analyzed by using Trypan Blue.Results: Both MEL receptors (MT1 and MT2) were detected at the mRNA and protein levels in 661W cells. MEL partially prevented H2O2-mediated cell death (20-25%). This effect was replicated with IIK7 (a melatonin receptor agonist) when used at a concentration of 1M. Preincubation with luzindole (a melatonin receptor antagonist) blocked MEL protection. Kp7-6, an antagonist of Fas/FasL, blocked cell death caused by H2O2 similarly to what was observed for MEL. Fas, FasL, and caspase-3 expression was increased in cells treated with H2O2, and this effect was prevented by MEL. Finally, MEL treatment partially prevented the activation of caspase-3 caused by H2O2.Conclusions: The results demonstrate that MEL receptors are present and functional in 661W cells. MEL can prevent photoreceptor cell death induced by H2O2 via the inhibition of the proapoptotic pathway Fas/FasL-caspase-3.

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10:59

Melatonin may alleviate the side effects of busulfan for male patients during clinical treatment. GreenMedInfo

PMID:  Cell Physiol Biochem. 2017 ;44(6):2407-2421. Epub 2017 Dec 18. PMID: 29268276 Abstract Title:  Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress. Abstract:  BACKGROUND/AIMS: Busulfan is commonly used for cancer chemotherapy. Although it has the advantage of increasing the survival rate of patients, it can cause male infertility via damaging the testes and reducing sperm counts. Therefore, the underlying mechanism should be explored, and new agents should be developed to protect the male reproductive system from busulfan-induced damage. Endoplasmic reticulum stress (ERS) is considered a key contributor to numerous pathologies. Despite several studies linking ERS to toxicants, studies have yet to determine whether ERS is a contributing factor to busulfan-induced testicular damage. Melatonin is a well-known broad-spectrum antioxidant, anti-inflammatory and antitumour agent, but the effects of melatonin on busulfan-induced ERS in mouse testes damage are less documented.METHODS: The effects of melatonin were measured by immunofluorescence staining, Western blot, qRT-PCR analysis and flow cytometry assay. The underlying mechanism was investigated by measuring ERS.RESULTS: We found that ERS was strongly activated in mouse testes (in vivo) and the C18-4 cell line (in vitro) after busulfan administration. ERS-related apoptosis proteins such as caspase-12, CHOP and caspase-3 were activated, and the expression of apoptotic proteins such as P53 and PUMA were upregulated. Furthermore, we investigated whether melatonin reduced the extent of damage to mouse testes and improved the survival rates of busulfan-treated mice. When exploring the underlying mechanisms, we found melatonin could counteract ERS by decreasing the expression levels of the ERS markers GRP78, ATF6, pIRE1 and XBP1 in mouse testes and mouse SSCs (C18-4 cells). Moreover, it blocked the activation of ERS-related apoptosis proteins caspase-12, CHOP and caspase-3 and suppressed P53 and PUMA expression stimulated by busulfan both in vivo and in vitro.CONCLUSION: Our results demonstrate that ERS is an important mediator for busulfan-induced apoptosis. The attenuation of ERS by melatonin can prevent busulfan-treated SSCs apoptosis and protect busulfan-treated testes from damage. Thus, this study suggests that melatonin may alleviate the side effects of busulfan for male patients during clinical treatment.

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10:43

Melatonin may serve as an advanced strategy to strengthen oral health to counteract periodontitis induced destructive damage. GreenMedInfo

PMID:  J Pineal Res. 2017 Dec 23. Epub 2017 Dec 23. PMID: 29274168 Abstract Title:  Prophylactic supplement with melatonin successfully suppresses the pathogenesis of periodontitis through normalizing RANKL/OPG ratio and depressing the TLR4/MyD88 signaling pathway. Abstract:  Periodontitis (PD) is an inflammatory disease characterized by gingival inflammation and resorption of alveolar bone. Impaired receptor activator of nuclear factor-kappa B ligand/osteoprotegerin (RANKL/OPG) signaling caused by enhanced production of pro-inflammatory cytokines plays an essential role in the pathogenesis of PD. Considering melatonin possesses significant anti-inflammatory property, this study aimed to determine whether prophylactic treatment with melatonin would effectively normalize RANKL/OPG signaling, depress toll-like receptor 4/myeloid differentiation factor 88 (TLR4/MyD88)-mediated pro-inflammatory cytokine activation, and successfully suppress the pathogenesis of PD. PD was induced in adult rats by placing the ligature at molar subgingival regions. Fourteen days before PD induction, 10, 50, or 100 mg/kg of melatonin was intraperitoneally injected for consecutive 28 days. Biochemical and enzyme-linked immunosorbent assay were used to detect TLR4/MyD88 activity, RANKL, OPG, interleukin 1, interleukin 6, and tumor necrosis factor- levels, respectively. The extent of bone loss, bone mineral intensity, and calcium intensity was further evaluated by scanning electron microscopy, micro-computed tomography, and energy-dispersive X-ray spectroscopy. Results indicated that high RANKL/OPG ratio, TLR4/MyD88 activity, and pro-inflammatory cytokine levels were detected following PD. Impaired biochemical findings paralleled well with severe bone loss and reduced calcium intensity. However, in rats pretreated with melatonin, all above parameters were successfully returned to nearly normal levels with maximal change observed in rats receiving 100 mg/kg. As prophylactic treatment with melatonin effectively normalizes RANKL/OPG signaling by depressing TLR4/MyD88-mediated pro-inflammatory cytokine production, dietary supplement with melatonin may serve as an advanced strategy to strengthen oral health to counteract PD-induced destructive damage.

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10:36

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease. GreenMedInfo

PMID:  Clin Nutr. 2017 Dec 12. Epub 2017 Dec 12. PMID: 29275919 Abstract Title:  Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. Abstract:  BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administration on metabolic status in diabetic patients with CHD.METHODS: This randomized, double-blind, placebo-controlled trial was conducted and involved 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 30) or placebo (n = 30) once a day for 12 weeks.RESULTS: Compared with the placebo, melatonin supplementation resulted in significant increases in plasma glutathione (GSH) (+64.7  105.7 vs. -11.1  137.6 mol/L, P = 0.02) and nitric oxide (NO) (+0.9  4.7 vs. -3.3  9.6 mol/L, P = 0.03), and significant decreases in malondialdehyde (MDA) (-0.2  0.3 vs. +0.1  0.5 mol/L, P = 0.007), protein carbonyl (PCO) (-0.12  0.08 vs. +0.03  0.07 mmol/mg protein, P 

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10:23

The Many Benefits of Buckwheat for Food and Garden The Healthy Home Economist

buckwheatBuckwheat is one of my favorite plants. For gardeners, it produces beautiful flowers that attract bees galore! Cultivation also serves as a valuable cover crop for protecting and improving soil. As icing on the cake, it provides a nutrient dense, gluten and grain free food option for people, poultry and other livestock.

Is Buckwheat a Type of Wheat?

10:05

Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers. GreenMedInfo

PMID:  Ann Agric Environ Med. 2017 Dec 23 ;24(4):659-666. Epub 2017 May 11. PMID: 29284244 Abstract Title:  Melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers - A study in postmenopausal women. Abstract:  INTRODUCTION AND OBJECTIVE: Protective antioxidative effects of melatonin have been repeatedly documented in experimental and clinical studies. One of the most spectacular exogenous prooxidative agents is cigarette smoking. The aim of the study was to evaluate the level of oxidative damage to membrane lipids (lipid peroxidation; LPO) in blood serum, and in epidermis exfoliated during microdermabrasion collected from former-smokers who were treated with melatonin.MATERIAL AND METHODS: The study was performed in postmenopausal women. Ninety (90) female volunteers, aged 46-67 years, were enrolled. Two major groups, i.e. never-smokers (n=44) and former-smokers (n=46), were divided into: Control, melatonin topical skin application, Restructurer (containing antioxidants) topical skin application, and melatonin oral treatment. Microdermabrasion was performed at point '0', after 2 weeks, and after 4 weeks of treatment. The following parameters were measured: LPO in blood serum, LPO in epidermis exfoliated during microdermabrasion, and skin biophysical characteristics, such as sebum, moisture, elasticity, and pigmentation. Malondialdehyde+4-hydroxyalkenals level (LPO index) was measured spectrophotometrically.RESULTS: Melatonin oral treatment significantly reversed the increased serum LPO level in former-smokers already after 2 weeks of treatment. In a univariate regression model, LPO blood level constituted the only independent factor negatively associated with melatonin oral treatment. After 4 weeks of treatment, melatonin given orally increased skin sebum, moisture and elasticity levels, and melatonin applied topically increased sebum level.CONCLUSIONS: Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.

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09:53

Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification. GreenMedInfo

PMID:  Toxicol Appl Pharmacol. 2017 Dec 28 ;340:30-38. Epub 2017 Dec 28. PMID: 29289671 Abstract Title:  Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification. Abstract:  Given the potential biological functions of spermatogonial stem cells (SSCs) in spermatogenesis and in delivering parental genetic information to the next generation, how these cells respond to environmental toxins and carcinogens should be investigated. We examined the toxic effect of hexavalent chromium (Cr(VI)) on global histone modifications and apoptotic signaling pathways in SSCs. We determined the effect of melatonin, one of the most powerful endogenous free radical scavengers and wide-spectrum antioxidants, in protecting SSCs from Cr(VI)-induced apoptosis and global histone modification by Western blot analysis. In addition, we examined the in vivo effect of melatonin on Cr(VI)-induced histological changes of seminiferous tubules in mouse testes. We also evaluated the fertility of male mice by monitoring litter size following intraperitoneal injection of these chemicals. Our study demonstrated the Cr(VI)-induced global increases in H3K9me3 and H3K27me3 and activated the apoptotic signaling pathway. Pretreatment of SSCs with melatonin alleviated Cr(VI)-induced apoptosis and the global increase of H3K9me3. Exposure to melatonin also attenuated the Cr(VI)-induced increase of the abundance of histone methyltransferase ESET. Furthermore, exogenous administration of melatonin protected mice against Cr(VI)-induced changes in testicular histology and germ cell apoptosis, which helped maintain normal spermatogenesis and male fertility. Our study revealed a potential new therapeutic approach for male reproductive injury caused by Cr(VI).

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09:38

Pre-administration of melatonin can ameliorate the oxidative damage induced by ionizing radiation. GreenMedInfo

PMID:  J Med Phys. 2017 Oct-Dec;42(4):245-250. PMID: 29296039 Abstract Title:  Modulation of Radiation-induced Base Excision Repair Pathway Gene Expression by Melatonin. Abstract:  Objective: Approximately 70% of all cancer patients receive radiotherapy. Although radiotherapy is effective in killing cancer cells, it has adverse effects on normal cells as well. Melatonin (MLT) as a potent antioxidant and anti-inflammatory agent has been proposed to stimulate DNA repair capacity. We investigated the capability of MLT in the modification of radiation-induced DNA damage in rat peripheral blood cells.Materials and Methods: In this experimental study, male rats (n = 162) were divided into 27 groups (n = 6 in each group) including: irradiation only, vehicle only, vehicle with irradiation, 100 mg/kg MLT alone, 100 mg/kg MLT plus irradiation in 3 different time points, and control. Subsequently, they were irradiated with a single whole-body X-ray radiation dose of 2 and 8 Gy at a dose rate of 200 MU/min. Rats were given an intraperitoneal injection of MLT or the same volume of vehicle alone 1 h prior to irradiation. Blood samples were also taken 8, 24, and 48 h postirradiation, in order to measure the 8-oxoguanine glycosylase1 (Ogg1), Apex1, and Xrcc1 expression using quantitative real-time-polymerase chain reaction.Results: Exposing to the ionizing radiation resulted in downregulation of Ogg1, Apex1, and Xrcc1 gene expression. The most obvious suppression was observed in 8 h after exposure. Pretreatments with MLT were able to upregulate these genes when compared to the irradiation-only and vehicle plus irradiation groups (P

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09:10

Melatonin treatment decreased PM2.5-induced oxidative stress level in the brains and lungs and relieved airway inflammation and chronic cough. GreenMedInfo

PMID:  Physiol Res. 2018 Jan 5. Epub 2018 Jan 5. PMID: 29303602 Abstract Title:  Melatonin attenuates chronic cough mediated by oxidative stress via transient receptor potential melastatin-2 in guinea pigs exposed to particulate matter 2.5. Abstract:  The aim of this study was to investigate the effects of melatonin on oxidative stress, the expression of transient receptor potential melastatin-2 (TRPM2) in guinea pig brains, and the influence of melatonin on oxidative stress in lungs and airway inflammation induced by particulate matter 2.5 (PM2.5). A particle suspension (0.1 g/ml) was nasally administered to the guinea pigs to prepare a PM2.5 exposure model. Cough frequency and cough incubation period were determined through RM6240B biological signal collection and disposal system. Oxidative stress markers, including malondialdehyde (MDA), total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), and glutathione peroxidase (GSH-Px), in the medulla oblongata were examined through spectrophotometer. Reactive oxygen species (ROS) were detected in the hypoglossal nucleus, cuneate nucleus, Botzinger complex, dorsal vagal complex, and airway through dihydroethidium fluorescence. Hematoxylin-eosin (HE) staining and substance P expression via immunohistochemistry revealed the inflammatory levels in the airway. TRPM2 was observed in the medulla oblongata through immunofluorescence and western blot. The ultrastructure of the blood-brain barrier and neuronal mitochondria was determined by using a transmission electron microscope. Our study suggests that melatonin treatment decreased PM2.5-induced oxidative stress level in the brains and lungs and relieved airway inflammation and chronic cough. TRPM2 might participate in oxidative stress in the cough center by regulating cough.

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09:08

Glyphosate and Fungicides Attract Honey Bees To Them Bee Decline Natural Blaze

By Natural Blaze

Turns out that Monsantos Big Ag weedkiller and fungicides might lure bees like.well, like a flower to a bee. And like a sweet poison

Recently, we reported the a surprising culprit behind the bee decline might actually be fungicides.  It does appear that fungicides were an overlooked poison to the bees and there might now be a connection. Just on the heels of this discover, we find more disturbing news

The journal Scientific Reports states this alarming conclusion,

When given the choice, honey bee foragers prefer to collect sugar syrup laced with the fungicide chlorothalonil over sugar syrup alone.

Recent studies have linked fungicides to declines in honey bee and wild bee populations. One recent study, for example, found parallels between the use of chlorothalonil and the presence of Nosema bombi, a fungal parasite, in bumble bees. Greater chlorothalonil use also was linked to range contractions in four declining bumble bee species.

Other research has shown that European honey bees have a very limited repertoire of detoxifying enzymes and that exposure to one potentially toxic compound including fungicides can interfere with their ability to metabolize others.

People assume that fungicides affect only fungi, said University of Illinois entomology professor and department head...

09:06

10 Ways to Prepare for WWIII Natural Blaze

prepare WW3

By Jeremiah Johnson 

By now youre poignantly aware of the false-alarm that was raised in Hawaii on Saturday 1/13/18.  For 38 minutes there was wholesale panic and alarm after the following message alert was sent out to cell phones and over the TV and radio throughout the state:

BALLISTIC MISSILE THREAT INBOUND TO HAWAII. SEEK IMMEDIATE SHELTER. THIS IS NOT A DRILL.  (Hawaii Emergency Management Agency)

This message was later rescinded as a false-alarm.  Great, huh?  In the meantime, people panicked.  News reports told of people gathered in hotel lobbies in a state of semi-paralysis, wondering what to do.  One woman (a schoolteacher) attempted to enter a shelter only to find that it was locked.  A professional golfer and his family hid beneath a mattress in the bathroom of a hotel, hoping the attack was not happening.  Other people placed their children inside of storm drains, and still others called authorities with no answer.

Preparing Falls to You

The bottom line: the government was not prepared to deal with it had it been an actual emergency, and individuals were next to helpless in the face of the threat.

The government will not be able to help you, even...

09:04

The Dangers of Processed Foods Exposed in Numerous Studies Natural Blaze

By Anna Hunt

To many people, news and research about the positive effects of superfoods are sufficient motivation to eat healthy. Yet, sometimes we need a stark reminder of the dangers of processed foods to stay on track with our diet goals.

When you go into the grocery story, an overwhelming majority of the foods sold have been altered form their natural state. Typically, this is done to make things more convenient for the consumer.

One can categorize processed foods into groups. First, there are minimally and semi-processed foods. These include frozen vegetables, fruit juice, roasted nuts, white rice, etc. These are typically very similar to natural foods and are most-often an acceptable part of a healthy diet.

The second category are ultra-processed foods. In this category, producers use chemicals, food additives, nitrates, salts, food dyes, etc. in the production of food products. Five of the most-commonly eaten foods in the U.S. are all ultra-processed: sugary soft drinks, cakes and pastries, burgers, pizza, and chips.

Below are three pieces of recent research that emphasize what might happen when your diet consists of too many of these ultra-processed and chemical-ridden foods.

One of the Dangers of Processed Foods is Cancer

Canadian researchers recently published a study that attributed to 41% of the instances of cancer to lifestyle and environmental factors. Personal choices when it comes to diet ranked very high on the list. The study stated...

08:48

How Much Apple Cider Vinegar Should You Drink? Healthy and Natural World

Apple cider vinegar is made from fermenting apples and has amazing health benefits. Drinking diluted apple cider vinegar can help to get rid of toxins from your body, assist in weight loss programs, and has cardiovascular benefits. So, you may be wondering how much apple cider vinegar you should drink to benefit your health.

Drinking the right amounts of apple cider vinegar a day to stay healthy isnt hard to do. At first, you might have to get used to the strong taste of diluted apple cider vinegar. However, you can add some delicious honey to improve its taste. This will help make sure that you are able to drink apple cider vinegar in the right quantities to benefit from it.

Consuming very large amounts of apple cider vinegar (ACV) daily has been associated with a mineral imbalance in the body. But, taking 2-4 tablespoons of apple cider vinegar is generally a safe amount. There are also some precautions with the daily dose of apple cider vinegar to avoid damaging tooth enamel or upsetting your digestive system.

In this article, I will look at how much apple cider vinegar per day you can safely drink. You will also find out how consuming small amounts of apple cider vinegar daily can help give your health a great boost.

What is Apple Cider Vinegar?

Apple cider vinegar has been used for centuries as a health tonic and to help disinfect wounds. Apple cider vinegar is made from fermenting apples and adding bacteria which converts the alcohol to acetic acid. This results in a liquid that has antiseptic properties and healthy bacteria.

The main active ingredient in apple cider vinegar is acetic acid which has potent health benefits.

Apple cider vinegar contains about 1 calorie per teaspoon or 3 calories per tablespoon, which is very low.

Organic, raw, unfiltered apple cider vinegar (like Braggs or other organic brands) contains the mother which gives it a cloudy appearance. The mother contains healthy enzymes and bacteria that could be responsible for some of the vinegars health benefits.

According to the journal Medscape General Medicine, apple cider vinegar contains vitamins, minerals, amino acids, and polyphenolic compounds. This means that apple cider vinegar contains antioxidant compounds that can help kill off free radicals when consumed.1

The journal also said that among the benefits of drinking small amounts of apple cider vinegar daily are boosting cardiovascular health, controlling blood glucose levels, and ridding the body of toxins.

How Much Apple Cider Vinegar Should You Drink?

There is no official apple cider vinegar dosage per day but most people consume 1-4 tablespoons of apple cider vinegar daily. Because diluted apple cider vinegar has a strong taste, many people start off by drinking sm...

08:47

Abandoned and Denied Audio Bite #16 Advocates for Dr. Sebi

Dr. Sebi is known for sharing the message that BLACK PEOPLE cure AIDS. A message that he began subscribing to after realizing that the world was being deprived of the knowledge of his accomplishments because of the people who did not like him. A method that thousands of others could Continue reading

08:34

Almond consumption as a preload modified body fat percentages, whereas snacking on almonds between meals improved blood lipid profiles. GreenMedInfo

PMID:  Nutr Res Pract. 2017 Dec ;11(6):479-486. Epub 2017 Nov 22. PMID: 29209458 Abstract Title:  The effects of daily intake timing of almond on the body composition and blood lipid profile of healthy adults. Abstract:  BACKGROUND/OBJECTIVES: Timing of almond intake during a day may result differently in the perspectives of body composition and changes of lipid profile. The current study was conducted to compare the effects of daily almond intake as a preload versus as a snack on body composition, blood lipid profile, and oxidative and inflammation indicators among young Korean adults aged 20-39 years old.SUBJECTS/METHODS: Participants were randomly assigned to one of three groups: a pre-meal almond group (PM), a snack almond group (SN) in which participants were instructed to consume 56 g of almonds either as a preload before meals or as a snack between meals, respectively, and a control group (CL) in which participants were provided high-carbohydrate iso-caloric control food. Measurements were performed at baseline, weeks 8 and 16.RESULTS: A total of 169 (M 77/F 92) out of the 227 participants completed the study between June 2014 and June 2015 (n = 58 for PM; 55 for SN; and 56 for CL). A significant decrease in body fat mass was observed in the PM group at both weeks 8 and 16 compared with the CL. There were significant intervention effects on changes of body fat mass (P = 0.025), body fat percentages (P = 0.019), and visceral fat levels (P

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08:21

Medical Cannabis and Other Natural Potential Life-Saving Remedies for Chronic Obstructive Pulmonary Disease Health Impact News

Disabled man. His life depends on his oxygen tank. Asthma emphysema COPD. He is using a rescue inhaler.

by Paul Fassa
Health Impact News

The pharmaceutical remedies for COPD (chronic obstructive pulmonary disease), which may seem to help at first, are side effect nightmares that most COPD sufferers abandon upon discovering other more natural solutions.

Pharmaceuticals also usually fail to stop the progression of COPD into the later stages that demand oxygen tanks as ones partner for life.

There are several natural options existing that can make life less miserable for COPD sufferers. One option is medical cannabis.

Its too early to tell if cannabis can completely cure one with COPD, meanwhile it serves to relieve the anxiety of not breathing well while simultaneously restoring normal breathing and providing relief by dilating bronchial tubes and healing lung tissue.

One of the pioneers who helped forge medical marijuana legislation in Oregon, Dr. Phil Leveque, who passed away in 2015 at the age of 90, has prescribed cannabis for over 5,000 patients and stated for the record:

Marijuana is one of the best bronchodilators, much better than any other class of drugs. For these respiratory diseases, [asthma and COPD] marijuana can be life-saving.

Dr. Leveque also claimed that smoking marijuana was not bad for the lungs, claiming cannabinoids are beneficial for lung tissues.

There are published studies that confirm Dr. Leveques assertion. In some cases, lung function increased with pot smokers who did not use tobacco cigarettes that are saturated with 600 added chemicals, mostly toxic and carcinogenic. (Source)

Studies that attest to support Dr. Leveques view may be accessed here.

Chronic Obstructive Pulmonary Disease

...

08:17

Fertility outcomes can be improved by melatonin it enhances progesterone receptor expression. GreenMedInfo

PMID:  Cell J. 2018 Apr ;20(1):108-112. Epub 2017 Dec 1. PMID: 29308626 Abstract Title:  Evaluating The Effect of Melatonin on HAS2, and PGR expression, as well as Cumulus Expansion, and Fertility Potential in Mice. Abstract:  OBJECTIVES: Infertility is a worldwide health problem which affects approximately 15% of sexually active couples. One of the factors influencing the fertility is melatonin. Also, protection of oocytes and embryos from oxidative stress inducing chemicals in the culture medium is important. The aim of the present study was to investigate if melatonin could regulate hyaluronan synthase-2 (HAS2) and Progesterone receptor (PGR) expressions in the cumulus cells of mice oocytes and provide an in vitro fertilization (IVF) approach.MATERIALS AND METHODS: In this experimental study, for this purpose, 30 adult female mice and 15 adult male mice were used. The female mice were superovulated using 10 U of pregnant mare serum gonadotropin (PMSG) and 24 hours later, 10 U of human chorionic gonadotropin (hCG) were injected. Next, cumulus oocyte complexes (COCs) were collected from the oviducts of the female mice by using a matrix-flushing method. The cumulus cells were cultured with melatonin 10M for 6 hours and for real-time reverse transcription-polymerase chain reaction (RT-PCR) was used for evaluation of HAS2 and PGR expression levels. The fertilization rate was evaluated through IVF. All the data were analyzed using a t test.RESULTS: The results of this study showed that HAS2 and PGR expressions in the cumulus cells of the mice receiving melatonin increased in comparison to the control groups. Also, IVF results revealed an enhancement in fertilization rate in the experimental groups compared to the control groups.CONCLUSIONS: To improve the oocyte quality and provide new approaches for infertility treatment, administration of melatonin as an antioxidant, showed promising results. Thus, it is concluded that fertility outcomes can be improved by melatonin it enhances PGR.

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07:56

Melatonin represses oral squamous cell carcinoma metastasis by inhibiting tumor-associated neutrophils. GreenMedInfo

PMID:  Am J Transl Res. 2017 ;9(12):5361-5374. Epub 2017 Dec 15. PMID: 29312489 Abstract Title:  Melatonin represses oral squamous cell carcinoma metastasis by inhibiting tumor-associated neutrophils. Abstract:  Tumor-associated neutrophils (TANs) promote metastasis of multiple cancers, including oral squamous cell carcinoma (OSCC). Melatonin (Mel) reportedly exerts anti-metastatic effects on OSCC. However, little is known about the anti-OSCC effects of Mel involved in TANs. In this study, intensive infiltration of TANs was positively associated with advanced stage, lymphatic metastasis, and poor prognosis of OSCC. Moreover, Mel reduced the survival and migration of OSCC-associated neutrophils. Mechanistically, Mel suppressed the TAN release of C-X-C motif chemokine ligand 8, C-C motif chemokine ligand 2 (CCL2), CCL4, and matrix metalloproteinase-9 by blockage of p38 MAPK and Akt signaling. Mel-fostered TANs decreased the migration and invasion of OSCC cells and reduced tube formation in vitro. Additionally, Mel-hampered pro-motility and pro-angiogenesis effects of TANs were dependent on MMP-9 suppression in OSCC. Overall, The beneficial roles of melatonin in retarding OSCC metastasis were implicated with inhibition of TANs.

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07:42

Melatonin may be considered a possible therapy against trauma and sports related muscle injury. GreenMedInfo

PMID:  J Sports Sci. 2018 Jan 9:1-5. Epub 2018 Jan 9. PMID: 29313427 Abstract Title:  Melatonin therapy for blunt trauma and strenuous exercise: A mechanism involving cytokines, NFB, Akt, MAFBX and MURF-1. Abstract:  Muscle injury occurs due to trauma, strenuous exercise or sports activities; most people affected are athletes. Ineffectively treated muscle injury can negatively affect sports careers and quality of life after retirement from sports. Reports have indicated that the current therapeutic management of muscle injury, particularly anti-inflammatory drugs, are not necessarily effective. Therefore, better therapies are required. Accumulating evidence has demonstrated melatonin's potent antioxidant and anti-inflammatory actions against musclepathology in sarcopenia or atrophy in systemic disease. However, the underlying mechanisms for the protective effect of melatonin in the context of trauma/strenuous exercise are multifactorial and not well described. This paper reviews data on melatonin's impact on muscle injury and findings that points toward the mechanisms through which melatonin achieves muscle protection. The general concept described in this review is that melatonin inhibits NFB, reduces cytokine expression, increases Akt that downregulates the ratio of MAFBX and MURF-1 in order to limit the extent of muscle injury andpromote muscle recovery post-injury. The work discussed in this review supports the notion that melatonin may be considered a possible therapy against trauma/sports related muscle injury. Inclusion of melatonin as a therapy in sports medicine could therefore provide a better treatment option for injured athletes and sports individuals.

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07:33

FORMER CAMPAIGN MANAGER: Trump must fulfill vaccine safety now with deep state on defense Vaxxter

Roger Stone, Trumps former campaign head, is pulling few punches when he exclaims what he feels Trump needs to be doing in terms of vaccine safety in America. In an article written by Stone, which...

The post FORMER CAMPAIGN MANAGER: Trump must fulfill vaccine safety now with deep state on defense appeared first on Vaxxter.

07:24

Melatonin protects against A-induced neurotoxicity in primary neurons. GreenMedInfo

PMID:  Biofactors. 2018 Jan 11. Epub 2018 Jan 11. PMID: 29322615 Abstract Title:  Melatonin protects against A-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway. Abstract:  Alzheimer's disease (AD) is a kind of neurodegenerative disorder associated with age. Investigations suggest that amyliod- (A) is implicated in the pathogenesis of AD. The accumulation of A in the brain causes oxidative stress and synaptic toxicity, leads to synaptic dysfunction and neuronal death. Previous investigations suggest that melatonin an endogenous hormone can counteract A-induced neurotoxicity. However, the molecular mechanisms of A-induced toxicity and melatonin treatment remain elusive. Studies indicate that microRNA-132 is crucial for neuronal survival and plays a key role in the pathological process of AD. Moreover, PTEN and FOXO3a two key targets of miR-132 are upregulated in the AD brain. Here, we exposed the primary cultured cortical neurons with A25-35 and treated with melatonin. Our investigations demonstrated that A25-35 exposure significantly decreased the expression of miR-132 and elevated the expression of PTEN and FOXO3a. Whereas, melatonin treatment could rescue the expression of miR-132 and downregulate the level of PTEN and FOXO3a. Moreover, melatonin blocked the nuclear translocation of FOXO3a and thereby suppressed its pro-apoptotic pathways. In addition, our investigations suggested that the over-expression of miR-132 could block A-induced neurotoxicity.We also found that VO-OHpic (PTEN inhibitor) could counteract A-induced neuronal damage, and LY294002 (AKT inhibitor) suppressed the protective effect of melatonin. Together, these results indicate that melatonin exerts its neuroprotective effect in A-induced neurotoxicity via miR-132/PTEN/AKT/FOXO3a pathway. 2018 BioFactors, 00(00):000-000, 2018.

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07:15

Melatonin may increase cell survival in the hippocampus via decreasing oxidative stress and SIRT2 expression and increasing Bcl-2 expression. GreenMedInfo

PMID:  Brain Res Bull. 2018 Jan 8 ;137:306-310. Epub 2018 Jan 8. PMID: 29325994 Abstract Title:  The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats. Abstract:  OBJECTIVE: Though the mechanisms are not clearly understood, melatonin and curcumin have been reported to have neuroprotective effects. However, the mechanisms of neuroprotective effects of melatonin and curcumin in the brain are not clearly understood. In the current study, we investigated the effects of melatonin and curcumin treatments on oxidative stress parameters, the expression of SIRT2, Bcl-2 and Bax in the hippocampus.METHODS: A total of thirty adult (13 months-old) male Wistar rats were divided into five groups: Control (1% ethanol:PBS), s.c. for 30days), dimethyl sulfoxide (10%, s.c. for 30days), Melatonin (10mg/kg/day, s.c. for 30days), Curcumin (30mg/kg/day, i.p. for 30days) and Salermide (100M, i.p. for 30days). The levels of malondialdehyde (MDA) glutathione (GSH) were measured as oxidative stress parameters in the hippocampus. The expression levels of SIRT2, Bcl-2 and Bax proteins were tested by western blotting and the SIRT2 protein levels of the hippocampal region was measured by a sandwich ELISA method.RESULTS: Melatonin and curcumin significantly decreased MDA and SIRT2 expression in the hippocampus (p

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07:09

This Will Kill 100 People Today But FDA Continues to Eliminate the Alternatives The Alliance for Natural Health

FDA opens a new front in the war against natural medicine.  Action Alert!

In the midst of an opioid epidemic that is killing nearly 100 people every day, the FDA has taken action against a natural medical food that offers patients an alternative to opioids.

Last November, the FDA posted a warning on its website concerning Limbrel, a medical food* marketed by Primus Pharmaceuticals for the management of osteoarthritis. Then, in December, the agency recommended that Primus voluntarily recall Limbrel. The stated reason for the warning is that the FDA is investigating serious adverse events involving Limbrel.  In a letter to Primus, the FDA states that 194 adverse event reports for Limbrel were received between 2007 and 2017about 20 a year.

Consider that NSAIDs (non-steroidal anti-inflammatory drugs), an alternative treatment for arthritis, cause approximately 107,000 hospitalizations every year, along with an estimated 16,500 deaths among arthritis patients alone.

Limbrels two main ingredients are Chinese skullcap and catechin, a flavonol and antioxidant found in blueberries and other fruits, as well as brewed tea, chocolate, and red wine. Chinese skullcap has been used safely in traditional Chinese medicine for many, many years.

Further, FDA asserts that Limbrel doesnt meet the definition of a medical food. To those familiar with the FDAs final guidance on medical foods, this should come as no surprise. As weve detailed previously, that guidance drastically limits the number of medical conditions that medical foods can claim to help manage. FDAs examples are restricted to rare genetic conditions that affect a small fraction of people, and are not applicable to patients who have more common disorders, no matter how controllable the condition might be with medical foods.

To give a sense for how outrageous the agencys thinking is on this matter, the guidance specifically excludes diabetesboth type 1 and type 2, as well as gestational...

07:06

Finally! Some Relief From Health Insurance Straight Jacket The Alliance for Natural Health

Help us support the first meaningful step in healthcare reform. Action Alert!

The Labor Department recently released its proposed regulations to implement President Trumps executive order by expanding association health plans.

Youll recall from our previous coverage that the executive order expands association health plans, also known as small group health plans. The idea is that individuals with a common profession or interest should be able to band together and count as a large group for health insurance purposes. Importantly, these plans are exempted from certain Obamacare requirements, such as covering essential health benefits. Large-group plans also have more leeway in setting premiums, which can be based on the health of the group (currently barred under the Obama-era rules).  Associations that gain large-group status could therefore offer less expensive, less expansive coverage if they were made up mainly of healthier members.

The Labor Department estimates that as many as 11 million Americans could get coverage under this proposal, which moves toward establishing the parallel, consumer-driven health care system that ANH advocates.

We are also awaiting rules that will extend the duration of short-term health plans, which do not have to adhere to Obamacare regulations, from 90 days to one year. This rule will also give Americans more choices with lower rates.

Action Alert! Write to the Labor Department and tell them you support expanding access to association health plans as a means of providing more freedom of choice in health care. Please send your message immediately.

06:14

Tennessee Kidnaps 3 Boys from Mentally Disabled Mom Refuses Grandmother Custody in Favor of Adoption to Strangers Health Impact News

Whitney 3 brothers

Adoptable brothers Bentyn, Ethyn, and Kamdyn were taken from a disabled mother and are now cut off from all family members. Photo provided by family.

by Health Impact News/MedicalKidnap.com Staff

A grandmother is fighting to save 2 generations of her family from abuse by the state of Tennessee. Through no fault of her own, her family is being ripped apart, in a terrifying sequence of events that could happen to anyone.

She is afraid for 3 of her grandsons who were seized by Tennessee Department of Childrens Services (DCS) from their mentally disabled mother. They have suffered horrific abuse in foster care. Now the state is attempting to sever all family ties so that they can adopt them out to strangers.

She is also fearful for the life of her 33 year old daughter Tara, the boys mother, whose mental illness became much worse after the boys were taken. When they learned of the abuse of the boys in foster care, the sense of utter helplessness to protect them pushed her daughter over the edge.

The law provides for families to do what families do for those members who are capable to step in and help other family members who are incapacitated in some way.

However, in this familys case, the state seems determined to keep that from happening.

Violation of Civil Rights for Disabled Mom

Whitney and Tara

Whitney Manning (left) with her daughter Tara. Photo provided by family.

Whitney became conservator over her daughters affairs when Taras mental health declined to the point where she couldnt take care of them on her own.

Tara has suffered from depression, anxiety, bipolar disorder, and ADHD for many years. Since her children were taken, Tara has declined dramatically. She has now been diagnosed with psychosis and schizoaffective disorder.

There are provisions in the Americans with Disabilities Act (ADA) that should have been followed by DCS but allegedly have not been followed in this case. Though it is documented that DCS has known about her mental illness from the beginning of their involvement, they have reportedly failed to addre...

06:01

The proliferations of Caco-2, MCF-7, and HELA cells were more inhibited when treated with water-soluble extract of fermented camel milk extracts. GreenMedInfo

PMID:  J Dairy Sci. 2018 Feb ;101(2):900-911. Epub 2017 Dec 8. PMID: 29224862 Abstract Title:  In vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant activities of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk. Abstract:  This study aimed to investigate in vitro anticancer activity by antiproliferative activity, antihypertensive activity by angiotensin-converting enzyme inhibition, antidiabetic activity by-amylase and -glucosidase inhibitions, and antioxidant activities of camel milk fermented with camel milk probiotic compared with fermented bovine milk. The camel milk probiotic strain Lactococcus lactis KX881782 (Lc.K782) and control Lactobacillus acidophilus DSM9126 (La.DSM) were used to prepare fermented camel and bovine milks separately. The proteolytic activities of water-soluble extract (WSE) in all fermented camel milk were higher than those in fermented bovine milk. The -glucosidase inhibitions in both milk types fermented by Lc.K782 ranged from 30 to 40%. Camel milk fermented byLc.K782 had the highest antioxidant activity by 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulphonic acid). The highest angiotensin-converting enzyme inhibition of WSE in camel milk fermented by Lc.K782 was>80%. The proliferations of Caco-2, MCF-7, and HELA cells were more inhibited when treated with WSE of fermented camel milk extracts.

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05:51

7 Tips to Choose and Get the Most out of a CSA Natural Blaze

Become a CSA Member: Invest in Local Farms, Reap Delicious Rewards

With the New Year already in motion, we are quickly approaching the season of plentiful fruits and vegetables. It wont be long until we are enjoying a bounty of fresh cut greens, spicy arugula, spring onions, strawberries and, soon enough, juicy tomatoes and buttery potatoes! So how can you ensure these goodies make it to your table? You can join a local CSA Community Supported Agriculture!

What it Means for the Farm

Owls Nest Farm CSA

Photo: Owls Nest Farm

When signing up for a CSA share, a customer becomes a direct investor in their farm of choice. At the beginning of the farm season, people pay up front for a share that will typically last the entire growing season (though some farms offer extended CSAs that start early and end late.) By paying up front, customers are insuring cash flow to the farmer regardless of ebbs and flows in the growing period.

On weeks when their harvest might be a little smaller due to unpredicted outside forces or transitioning crops, the farmer wont have to take as substantial of a cut to sales. But dont worry, when the farmer exp...

05:34

The beneficial effect of the intake of a hazelnut capsule on the methylation levels of the ADRB3 gene was demonstrated for the first time. GreenMedInfo

PMID:  Clin Epigenetics. 2017 ;9:110. Epub 2017 Oct 13. PMID: 29046732 Abstract Title:  Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women. Abstract:  BACKGROUND: Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes.METHODS: This was a controlled intervention study involving 40 overweight and obese adult women in which food intake, anthropometric measurements, biochemical analyses, and methylation levels of the ADRB3 gene were evaluated before and after intervention. The individuals were randomized into four groups: group 1 (G1) received 300 g of vegetables and legumes containing on average 191 g/day of folate and 1 hazelnut oil capsule; group 2 (G2) received 300 g of vegetables and legumes containing on average 191 g/day of folate and 1 placebo capsule; group 3 (G3) received 300 g of vegetables and legumes containing on average 90 g/day of folate and 1 hazelnut oil capsule; and individuals in group 4 (G4) were only followed-up and maintained their regular dietary habits. Statistical analysis was performed using analysis of variance (ANOVA), Student's t test and simple regression, using STATA 13 software.RESULTS: In the total sample, after the intervention, the women classified as overweight and obese did not present weight loss, and there was a reduction in the methylation levels of the ADRB3 gene and malondialdehyde, as well as an increase in high-density lipoprotein cholesterol and total antioxidant capacity.CONCLUSIONS: The beneficial effect of the intake of a hazelnut capsule on the methylation levels of the ADRB3 gene was demonstrated for the first time.TRIAL REGISTRATION: ClinicalTrials.gov, NCT 02846025.

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05:29

Tennessee Kidnaps 3 Boys from Mentally Disabled Mom Refuses Grandmother Custody in Favor of Adoption to Strangers Medical Kidnap

Whitney 3 brothers

Adoptable brothers Bentyn, Ethyn, and Kamdyn were taken from a disabled mother and are now cut off from all family members. Photo provided by family.

by Health Impact News/MedicalKidnap.com Staff

A grandmother is fighting to save 2 generations of her family from abuse by the state of Tennessee. Through no fault of her own, her family is being ripped apart, in a terrifying sequence of events that could happen to anyone.

She is afraid for 3 of her grandsons who were seized by Tennessee Department of Childrens Services (DCS) from their mentally disabled mother. They have suffered horrific abuse in foster care. Now the state is attempting to sever all family ties so that they can adopt them out to strangers.

She is also fearful for the life of her 33 year old daughter Tara, the boys mother, whose mental illness became much worse after the boys were taken. When they learned of the abuse of the boys in foster care, the sense of utter helplessness to protect them pushed her daughter over the edge.

The law provides for families to do what families do for those members who are capable to step in and help other family members who are incapacitated in some way.

However, in this familys case, the state seems determined to keep that from happening.

Violation of Civil Rights for Disabled Mom

Whitney and Tara

Whitney Manning (left) with her daughter Tara. Photo provided by family.

Whitney became conservator over her daughters affairs when Taras mental health declined to the point where she couldnt take care of them on her own.

Tara has suffered from depression, anxiety, bipolar disorder, and ADHD for many years. Since her children were taken, Tara has declined dramatically. She has now been diagnosed with psychosis and schizoaffective disorder.

There are provisions in the Americans with Disabilities Act (ADA) that should have been followed by DCS but allegedly have not been followed in this case. Though it is documented that DCS has known about her mental illness from the beginning of their involvement, they have reportedly failed to address...

05:25

Drink of death: Agras dark secret Fluoride Action Network

Agra home to the Taj Mahal plus other Mughal-era monuments is a magnet for tourists, both domestic as well as foreign.

And besides lugging their cameras, tote bags and ruck sacks tourists carry the ubiquitous water bottles. For among Agras darkest secrets is the citys undrinkable water.

Recently the Agra administration got the water in Agra tested and it was found that in most of the Agra district, the fluoride levels in the water are way higher than the World Health Organization (WHO) standards.

A senior water works official told India Today that in five districts of Uttar Pradesh, the subsoil water has been found to have higher than normal fluoride levels.

The Central government has issued an alert, asking the UP government to take immediate action to resolve this situation.

He said that the affected UP districts include Agra, Ghazipur, Jhansi, Sonbhadra and Varanasi. Earlier Unnao, Raibareli, Firozabad, Mathura and Pratapgarh had also been counted in the fluoride-affected districts.

Since 2009 the National Fluorosis Prevention and Control Programme has been running in UP with the state government operating water-testing laboratories in the initially identified fluoride affected districts

There has been a growing chorus for more funds to establish labs and buy equipment and reagents; theres also the need for more manpower.

According to the health department sources, when the fluoride content of water rises above 1-1.5 parts per million (ppm), it starts creating health related issues fluorosis in the people drinking this water. This limit has been fixed by the WHO.

Fluorosis damages teeth and bones, according to Dr SK Kalra, a senior physician. He said that the early signs of the disease are vomiting, loss of appetite, flatulence, bloating, yellowing teeth, frequent urination, excessive thirst, joint pain, hunched back and crooked legs among others.

Dr Sushma Singh, deputy director of State Institute of Health and Family Welfare said that the central government has notified five districts that are affected by fluorosis and water-testing labs are being established there, for which budget has been requested under the National Health Mission.

Excessively high fluoride content causes Fluorosis

Health Department: When fluoride content of water rises above 1-1.5 ppm, it starts creating health related issues fluorosis.

In Patti Pachgai village of Agra, overall prevalence of skeletal fluorosis is 21.1 per cent.

Early signs of fluorosis: Vomiting, loss of appetite, flatulence, bloating, yellowing teeth, frequent urination, excessive thirst, joint pain, hunche...

04:58

Effect of fluoride on brain of albino-rabbit An experimental study. Fluoride Action Network

From Table 1: Gross and brain cyto-architecture changes of experimental animals at the end of 16 weeks.

Changes in Brain Cytoarchitecture: The neurones lost their angular or pyramidal shape and acquired a plump, ovoid, rounded, or characteristic ballooned appearance (Figure 1). The nucleus was displaced to the periphery or axonal base and was shrunken, pyknotic, or absent. Reduction in the number of Purkinje neurones and in some areas even complete loss of neurones. Pyramidal neurones exhibited chromatolysis, Nissl substance was not detectable, and the perikaryon was filled with numerous small colorless vacuoles (Figure 2). Neuroglial cells showed chromatolysis, and in the neuroplasm of these cells, one or two spheroid bodies were present. The nucleus was located at the periphery of the cell (Figure 3).

04:22

Being Bilingual Helps Autistic Children Natural Blaze

By Mae Chan

Children with Autism Spectrum Disorders (ASD) often have a hard time switching gears from one task to another. But being bilingual may actually make it a bit easier for them to do so, according to a new study which was recently published in Child Development.

Research has shown just how childrens brains can become bilingual so easily, findings that scientists hope eventually could help even those with autism.

This is a novel and surprising finding, says Prof. Aparna Nadig, the senior author of the paper, from the School of Communication Sciences and Disorders at McGill University. Over the past 15 years there has been a significant debate in the field about whether there is a bilingual advantage in terms of executive functions. Some researchers have argued convincingly that living as a bilingual person and having to switch languages unconsciously to respond to the linguistic context in which the communication is taking place increases cognitive flexibility. But no one has yet published research that clearly demonstrates that this advantage may also extend to children on the autism spectrum. And so its very exciting to find that it does.

The researchers arrived at this conclusion after comparing how easily 40 children between the ages of six and nine, with or without ASD, who were either monolingual or bilingual, were able to shift tasks in a computer-generated test. There were ten children in each category.

Blue rabbits or red boats

The children were initially...

04:10

2 Minute Warning- January 18, 2018 The Alliance for Natural Health

This weeks featured stories:

 

03:48

Aluminum and fluoride impacts cortex and hippocampus structure in rats: protective role of resveratrol. Fluoride Action Network

from Results and Discussion:

The neuronal damage and aggregation was observed in AlCl 3 + NaF treated group when compared to the control group where as less neuronal damage and aggregation was observed when Resveratrol administered along with AlCl 3 + NaF treatment. No morphological variation was observed in Resveratrol alone treated group as compared to the control group.

The amyloid protein plaques were formed in the AlCl 3 +NaF treated group as compared to the control group. The amyloid plaques were not observed in the Resveratrol along with AlCl 3 +NaF treated group as compared to the AlCl 3 +NaF treated group.

03:32

Neuroprotective effects of curcumin on sodium fluoride induced behavioural and enzymatic changes in brain and muscles of rat Fluoride Action Network

from Results and discussion:

The present study evidenced that sodium fluoride consumption showed alteration in motor, cognitive, nociceptive behaviour and induced significant changes in the oxidative stress; membrane bound enzymes activities in rat. The administration of curcumin simultaneously with sodium fluoride reduced the oxidative stress, increased enzymes activities and improved behavioural abilities in rats. Vani and Reddy (2000) reported decreased somatic index of muscle and brain in fluoride treated mice. It is evidenced in the present study that the body weight and organo somatic index (OSI) (Fig. 1a, b) of muscle (-26.72%) and brain (-15%) of fluoride exposed rats were decreased significantly (p<0.05) as compared to control, whereas the NaF+Curcumin treated group showed increased OSI of brain (-5.71%) and muscle (-10.34%) as compared to fluoride administered rats and results were nearer to control rats (p<0.05). The body, brain and muscle weights were proportionately reduced in fluoride treated rats as compared to control group individuals and improved in the above weights in curcumin received rats.

03:00

Is our database missing a retraction? Tell us! Retraction Watch

As many readers know, weve been hard at work curating a comprehensive database of retractions, and are now up to more than 16,000 entries. Despite that large number as much as triple what youll find in commonly used databases we know there are notices were missing. Were doing our best to fill in []

The post Is our database missing a retraction? Tell us! appeared first on Retraction Watch.

02:53

These results indicate a chemopreventive potential of in vitro fermented hazelnuts. GreenMedInfo

PMID:  Anticancer Res. 2018 01 ;38(1):83-93. PMID: 29277760 Abstract Title:  Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells. Abstract:  BACKGROUND/AIM: Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer.MATERIALS AND METHODS: Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6C/25 min, RC2=155.1C/20 min and RC3=180.4C/21 min) on chemopreventive effects of in vitro fermented hazelnuts was analyzed in LT97 colon adenoma cells.RESULTS: FS (2.5%) of raw and roasted hazelnuts reduced H2O2-induced DNA damage while 5% FS significantly induced gene expression of SOD2 (3.0-fold) and GSTP1 (2.1-fold). GPx1 mRNA levels were significantly decreased (0.6-fold) by FS (2.5%). The growth of LT97 cells was significantly reduced by hazelnut FS in a time- and dose-dependent manner. Hazelnut FS (5%) increased the numbers of early apoptotic cells (9.6% on average) and caspase-3 activities (6.4-fold on average).CONCLUSION: These results indicate a chemopreventive potential of in vitro fermented hazelnuts which is largely unaffected by the roasting process.

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02:41

A review of almond, hazelnut and walnuts for neuroprotection in Alzheimer's disease. GreenMedInfo

PMID:  Pharmacol Res. 2017 Dec 5. Epub 2017 Dec 5. PMID: 29208493 Abstract Title:  Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents. Abstract:  An increase in the prevalence of Alzheimer's disease (AD) as a multifactorial neurodegenerative disorder is an almost obvious issue in the world. Researches on natural products for finding effective drugs to prevent the disease are in progress. There is special attention to the three types of nuts including almond, hazelnut and walnut in manuscripts of traditional Persian medicine (PM) as the preventive agents against brainatrophy and memory loss. The purpose of this study is a pharmacological review of their bioactive constituents and introducing the value of these nuts as the effective supplements and natural medicinal foods in AD patients. Databases including PubMed and ScienceDirect were searched in title, abstract and keywords from year 2000 to present for AD-related researches on these tree nuts, their major phytochemicals and their mechanisms of action. As result, almond, hazelnut and walnut provide macronutrients, micronutrients, and phytochemicals which affect several pathways in AD pathogenesis such as amyloidogenesis, tau phosphorylation, oxidative stress, cholinergic pathways, and some non-target mechanisms including cholesterol lowering and anti-inflammatory properties, as well as effect on neurogenesis. These nuts are recommended in PM for their brain-protective activity and particularly reversing brain atrophy in case of hazelnut. The therapeutical statements of PM scholars mentioned in their books are based on their clinical observations with support of a long history of experiences. Beyond the molecular activities attributed to the phytochemicals, the use of these tree nuts could be more considered in scientific researches as the effective nutrients for prevention or even management of AD.

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02:18

HHS establishes a new Conscience and Religious Freedom (CRF) Division within its Office for Civil Rights, holds livestream today, Jan 18th at 10:30am EST. AGE OF AUTISM

by Ginger Taylor HHS establishes a new Conscience and Religious Freedom (CRF) Division within its Office for Civil Rights, holds livestream today, Jan 18th at 10:30am EST. The religious rights of families in Mississippi, California and West Virginia, along with...

02:13

ABC News Features Dr. Tenpennys Vaccine Info Page Vaxxter

Mainstream media is trying to figure out why the antivaccine movement is so big, active, and intelligent. Yesterday, ABCs Australian affiliate ran a story that discussed the concept of filter bubbles. The idea being that...

The post ABC News Features Dr. Tenpennys Vaccine Info Page appeared first on Vaxxter.

02:08

New California Wants to Break Away From Tyranny of California, Create 51st State REALfarmacy.com

Source: New California Wants to Break Away From Tyranny of California, Create 51st State For more content like this visit REALfarmacy.com.

by CAREY WEDLER Over the years, there have been several secession efforts in California aimed at breaking away from the U.S. government, including one that gained steam following Donald Trumps election in 2016. So far, none have been successful, but a new declaration from rural communities are now seeking independence not from the U.S., but from California itself. []

Source: New California Wants to Break Away From Tyranny of California, Create 51st State Learn more at REALfarmacy.com - Healthy News and Information.

01:53

From Picket Lines to Worry Lines Mad In America

Review: Iain Ferguson, Politics of the Mind: Marxism and Mental Distress. 2017, London: Bookmarks. 134 pages.

Iain Ferguson has experience as a psychiatric social worker, social work academic, socialist, trade unionist, and co-founder of Social Workers Action Network (SWAN) which advocates building unity in action between campaigning organizations of service users on the one hand and carers organizations on the other to prevent service cuts and closures. While his book addresses the U.K. and European experience, the basic arguments apply everywhere.

Ferguson aims to use the marxist approach not only to make sense of mental distress but also help us address and change the material conditions that give rise to it.

the central argument of this book is that it is the economic and political system under which we live  capitalism  which is responsible for the enormously high levels of mental health problems which we see in the world today.

He begins by describing the crisis in mental health that disproportionately affects the unemployed, poor, and oppressed. He attributes this crisis to rising poverty, increased work stress, the shredding of social supports, and a low level of class struggle. Workers feel more burdened, more alone, and less hopeful, leaving the picket lines of the past to join the worry lines of the present.

Ferguson emphasizes that the meaning people give to their experience can make the difference between sinking into despair and fighting back. If a worker interprets the loss of her job as a sign of personal unworthiness, she is more likely to sink into depression than if she recognizes that unemployment is necessary to capitalism and feels anger at being victimized.

In the chapter All in the brain? Ferguson critiques and rejects the medical model of mental distress, the DSM, the medicalization of everyday life, and the horrible history of psychiatric crimes. He concludes by briefly reviewing the challenge to biological psychiatry posed by social models of distress.

Ferguson points out that the model of social adversity is preferable to the model of faulty biology. However, it fails to acknowledge the class conditions that generate trauma. As a result, trauma is typically treated as an individual or individual-family problem instead of an intrinsic feature of capitalism. This enables right-wingers to attack distressed families for failing to support their childrens mental development, when studies show that raising family incomes is the most effective way to do this.

The final chapter presents Marxs theory of alienation as a means to understand the causes of mental distress and how to challenge them. Most people experience alienation as a lack of control over their work, their lives, and society. The resulting sense of powerlessness and disconnection is highly distressing.

...

01:41

President Trump Urged to Move on Vaccines by Former Campaign Head Roger Stone BolenReport

Roger Stone Says: Now that hes got the Deep State on defense, he should press his advantage by fulfilling his promises that gained him cross-party support that helped get him elected. He must move forward with his promise of appointing Robert F. Kennedy, Jr. to lead a Vaccine Safety Commission. Roger Stone, former head Continue reading President Trump Urged to Move on Vaccines by Former Campaign Head Roger Stone

The post President Trump Urged to Move on Vaccines by Former Campaign Head Roger Stone appeared first on BolenReport.

00:00

A painful lesson: Authors retract paper after discovering mislabeled mouse lines Retraction Watch

Neuroscientists have retracted a 2016 paper examining the genetic underpinnings of a degenerative motor neuron disease, after discovering that two mouse lines had been accidentally mislabeled. According to the retraction notice, published in December in Acta Neuropathologica Communications, mice engineered to have a specific genetic mutation were mislabeled as the normal or wild type group. []

The post A painful lesson: Authors retract paper after discovering mislabeled mouse lines appeared first on Retraction Watch.

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Thursday, 18 January

23:20

Dangerous New Trend: Tide Pod Challenge Gone Deadly 2018 REALfarmacy.com

Source: Dangerous New Trend: Tide Pod Challenge Gone Deadly 2018 For more content like this visit REALfarmacy.com.

Headlines are being made about millennials eating Tide Pod laundry detergent tablets. One from Unilad reads: Millennials Eating Washing Tablets Thanks To Stupid Tide Pod Challenge But people arent really eating laundry pods: at least 99.99% of people joking about it. Only the most elite crop of stupid people in the millennial generation would actually take []

Source: Dangerous New Trend: Tide Pod Challenge Gone Deadly 2018 Learn more at REALfarmacy.com - Healthy News and Information.

22:03

Mental Health Inc: A New Book by Art Levine Mad In America

From AlterNet: A new book my Art Levine, Mental Health Inc: How Corruption, Lax Oversight and Failed Reforms Endanger Our Most Vulnerable Citizens, exposes the greed and cronyism behind the countrys epidemic of psychiatric overmedication and malpractice.

Article

22:02

Histories of Violence: Neurodiversity and the Policing of the Norm Mad In America

In this interview for the Los Angeles Review of Books, cultural theorist and philosopher Erin Manning discusses neurodiversity, a movement that seeks to depathologize traits, experiences, and ways of existing that are categorized as disorders. Manning critiques the education systems inherent enforcement of neurotypicality and marginalization of those who diverge from the norm.

Neurodiversity is a movement that celebrates difference while remaining deeply nuanced on questions of (medical) facilitation and the necessity of rethinking the concept of accommodation against narratives of cure. The added emphasis on neurology has been necessary in order to challenge existing norms that form the base-line of existence: the neuro in neurodiversity has opened up the conversation about the category of neurotypicality and the largely unspoken criteria that support and reinforce the definition of what it means to be human, to be intelligent, to be of value to society. This has been especially necessary for those folks who continue to be excluded from education, social and economic life, who are regarded as less than human, whose modes of relation continue to be deeply misunderstood, and who are cast as burdens to society.

22:01

Why Its Time to Let Psychoanalysis Into Politics Mad In America

In this piece for Prospect, Susie Orbach explains how insights from psychoanalysis can help us understand our current political, social, and economic climate.

Politically, socially, ecologically and economically, we live in fragile times. The psychic fragilities are not confined to the poor who are the more obvious victims of the way weve been running the economy and society these last few decades. We could think of how they also exist for the very wealthy through the case of Harvey Weinstein. His constant predatory behaviour speaks to a kind of power so unsure of itself it needs constant confirmation and reiteration. If the power were not felt deep inside to be conflictual, it wouldnt need continual enactment. We see this in the consulting room, in which solutions are sought to expel pain and insecurity. If things run in a way which fosters more pain and insecurity, we can expect more of the addictive and hurtful patterns as well as the monstrous behaviours which are often a carapace for underlying vulnerabilities.

If fragility is the defining feature of our times, it is also what we therapists have always dealt with. With questions and worries and uncertainties, we endeavour to hold a frame while individuals, couples and groups, explore the multiple meanings of their dilemmas. People come to therapy looking for certainties.  We destabilise such notions because the process of self-reflection necessarily upends knowns. In the exploration of uncertainties, we discover societys hurts, the costs of hyper-masculinity, hyper-femininity and the fragile identities of  whiteness and class which mark allegiances which are often not in our best interests.

22:00

Trauma Resiliency Model: A New Somatic Therapy for Treating Trauma Mad In America

A mask, painted by a Marine who attends therapy for PTSD. (Official U.S. Marine Corps photo by Cpl. Andrew Johnston)

22:00

American Teens Eating A Big Bowl of Stupid: Laundry Detergent AGE OF AUTISM

By Kim Rossi There's no kind way to say this, so I won't attempt to hide my scorn, not at the kids but the system. American kids who are eating Tide laundry soap packets are not well. Yes, kids will...

21:59

James Lyons-Weiler PhD "New York Times Has Lost It" AGE OF AUTISM

Note: Vaccination rights continue to be a major issue facing Americans - despite most having no inkling or care about the topic. Until someone they love is vaccine injured. Thanks to James Lyons-Weiler for this article on the state of...

14:42

Walnuts exhibit chemopreventive effects regarding the risk for colon cancer development by inducing expression of genes involved in detoxification. GreenMedInfo

PMID:  Nutr Res. 2017 Nov ;47:72-80. Epub 2017 Sep 18. PMID: 29241580 Abstract Title:  In vitro-fermented raw and roasted walnuts induce expression of CAT and GSTT2 genes, growth inhibition, and apoptosis in LT97 colon adenoma cells. Abstract:  Walnuts are rich in bioactive compounds such as polyunsaturated fatty acids, polyphenols, and dietary fiber. Therefore, the consumption of walnuts can contribute to a healthy diet and may reduce the risk for colon cancer. Heat treatment like roasting may change the chemical composition of walnuts and therefore their chemopreventive properties. Therefore, the hypothesis of the present study is that different roasting conditions (RCs) alter the chemopreventive effects of walnuts. Thus, the aim of the present study was to investigate whether different RCs (RC1=139.7C/25 min, RC2=154.5C/20 min, and RC3=185.5C/25 min) alter the chemopreventive effects of walnuts. Raw and roasted walnuts were subjected to in vitro digestion and fermentation. After treatment of LT97 colon adenoma cells with fermentation supernatants (FSs), expression of CAT, SOD2, GPx1, GSTP1, and GSTT2 genes as well as cell growth and apoptosis was examined. In comparison to the fermentation blank control, walnut FS particularly increased mRNA levels of CAT 1.7-fold and GSTT2 3.1-fold, whereas GPx1 levels were significantly decreased 0.6-fold. Walnut FS decreased growth of adenoma cells in a time- and dose-dependent manner. In particular, higher concentrations of walnut FS (5%) significantly increased the number of early apoptotic cells 2.0-fold and induced caspase-3 activity 6.8-fold compared with the blank control. The roasting process had no direct impact on the observed effects. In sum, our results indicate that walnuts exhibit chemopreventive effects regarding the risk for colon cancer development by inducing expression of genes involved in detoxification (CAT, GSTT2) and by inducing growth inhibition and apoptosis in colon adenoma cells unaffected by moderate roasting.

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14:21

Walnut leaf extract exert protective effects against diabetic retinopathy. GreenMedInfo

PMID:  Iran J Basic Med Sci. 2017 Nov ;20(11):1275-1281. PMID: 29299206 Abstract Title:  Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat. Abstract:  Objectives: Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy.Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status.Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption (P

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14:05

Consumption of nuts was associated with a 13% to 19% lower risk of total cardiovascular disease and 15% to 23% lower risk of coronary heart disease. GreenMedInfo

PMID:  J Am Coll Cardiol. 2017 Nov 14 ;70(20):2519-2532. PMID: 29145952 Abstract Title:  Nut Consumption and Risk of Cardiovascular Disease. Abstract:  BACKGROUND: The associations between specific types of nuts, specifically peanuts and walnuts, and cardiovascular disease remain unclear.OBJECTIVES: The authors sought to analyze the associations between the intake of total and specific types of nuts and cardiovascular disease, coronary heart disease, and stroke risk.METHODS: The authors included 76,364 women from the Nurses' Health Study (1980 to 2012), 92,946 women from the Nurses' Health Study II (1991 to 2013), and 41,526 men from the Health Professionals Follow-Up Study (1986 to 2012) who were free of cancer, heart disease, and stroke at baseline. Nut consumption was assessed using food frequency questionnaires at baseline and was updated every 4 years.RESULTS: During 5,063,439 person-years of follow-up, the authors documented 14,136 incident cardiovascular disease cases, including 8,390 coronary heart disease cases and 5,910 stroke cases. Total nut consumption was inversely associated with total cardiovascular disease and coronary heart disease after adjustment for cardiovascular risk factors. The pooled multivariable hazard ratios for cardiovascular disease and coronary heart disease among participants who consumed 1 serving of nuts (28 g) 5 or more times per week, compared with the reference category (never or almost never), were 0.86 (95% confidence interval: 0.79 to 0.93; p for trend = 0.0002) and 0.80 (95% confidence interval: 0.72 to 0.89; p for trend 

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13:55

Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A. GreenMedInfo

PMID:  Thorac Cancer. 2018 Jan 13. Epub 2018 Jan 13. PMID: 29330934 Abstract Title:  Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. Abstract:  BACKGROUND: Background: BisphenolA (BPA) is an estrogen-like chemical widely contained in daily supplies. There is evidence that environmental exposure to BPA could contribute to the development of hormone-related cancers. As is reported in numerous studies, melatonin, an endogenous hormone secreted by the pineal gland, could markedly inhibit estrogen-induced proliferation of breast cancer (BC) cells. In this study, we intended to reveal the effects of melatonin on BPA-induced proliferation of estrogen receptor-positive BC cells.METHODS: Methods: We used methyl thiazolyl tetrazolium, luciferase reporter gene and western blotting assays to testify the effect of melatonin on BPA-mediated proliferation of MCF-7 and T47D cells.RESULTS: Methyl thiazolyl tetrazolium and colony formation assays showed that melatonin could significantly abolish BPA-elevated cell proliferation. Meanwhile, BPA-upregulated phosphorylation of ERK and AKT was decreased by melatonin treatment. Mechanistically, we found that BPA was capable of upregulating the protein levels of steroid receptor coactivators (SRC-1, SRC-3), as well as promoting the estrogen response element activity. However, the addition of melatonin could remarkably block the elevation of steroid receptor coactivators expression and estrogen response element activity triggered by BPA.CONCLUSION: Conclusions: Therefore, these results demonstrated that melatonin could abrogate BPA-induced proliferation of BC cells. Therapeutically, melatonin could be regarded as a potential medication for BPA-associated BC.

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Wednesday, 17 January

07:18

Top 5 Reasons NEVER to Take a Proton Pump Inhibitor GreenMedInfo

Millions of doses of "acid blocking" proton pump inhibitor drugs are doled out every year, yet most doctors and their patients are completely oblivious to their unintended, adverse effects, which include increased risk for premature death. 

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